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hemD

Gene
hemD
Protein
Porphyrin biosynthesis protein HemD
Organism
Clostridium josui
Length
504 amino acids
Function
May catalyze sequential reactions to synthesize uroporphyrinogen III from hydroxymethylbilane (HMB) and then precorrin-2, which are intermediate compounds in both vitamin B12 and siroheme biosyntheses.
Similarity
In the C-terminal section; belongs to the uroporphyrinogen-III synthase family.
Mass
55.211 kDa
Sequence
MEHGFVALVGAGPGDKGLITIRGAELLSQADVVVYDRLVSQEIIKMIPTTAEKIDVGKENKFHPVKQEEINHILLEKSLEGKKVIRLKGGDPFVFGRGGEELELLYENNIPFEVVPGVTSAVAALCYGGIPATHRDFCSSLHIITGHAREGGQLSIPFHELKELNGTIVFLMGDSSLSYLMNGLINAGMEKDMPAAIVENGTRPNQRKLVATVGTLEQKALEMEIKSPAIIAVGKVCSLSEKFSWFMKKPLFGTKILVTRPKESSGTLVEKLRQLGAEPVEYPCIEVVPIPQNEKLYHACENIREYGWILLTSKNGIQIFFDYLNSKGLDARVLANTKIGTVGSQTAKALKEVGLISDFTPEIFDGRHLALGIAERVGENEKVLICDAAIASDDIVNILRSNNIKFDRVPLYNTNYINENSNKVKKSIVHGELKYITFTSASTVEGFIASMKDIPLESLTAVCIGNKTAEAAKKYNLRYVVAEKSTIDSMIDKLLEIGGGNIYD
Protein
Porphyrin biosynthesis protein HemD: hemD

Gene
hemD
Protein
Uroporphyrinogen-III synthase
Organism
Synechococcus elongatus (strain PCC 7942)
Length
264 amino acids
Function
Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
Similarity
Belongs to the uroporphyrinogen-III synthase family.
Mass
28.196 kDa
Sequence
MAEQPLIGKTILTTRAAGQSSPFAAQLRAAGAAVIEMPTLEIGPPSSWLPLDEAIAAIADFDWLILASANAVEAVQQRLAAQQKSWSDVPCAIAVVGQKTAQVLAAQGGKADYIPPEFIAESLVEHFPQPVAGQRLLFPRVETGGREQITQALQSQGAIVVEVPAYESRCPSQIPDDALIALRQAHLNLISFTSSKTVRNFCQLMASNLGVDWSARISGVAIASIGPQTSITCQELLGRVEVEAQEYTLDGLLLAIEQWARQTT
Protein
Uroporphyrinogen-III synthase: hemD

Gene
hemD
Protein
Uroporphyrinogen-III synthase
Organism
Bacillus subtilis (strain 168)
Length
262 amino acids
Function
Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
Similarity
Belongs to the uroporphyrinogen-III synthase family.
Mass
29.114 kDa
Sequence
MENDFPLKGKTVLVTRNKAQAASFQQKVEALGGKAVLTSLITFRRALPNDVAEQVREDLAAPGWLVFTSVNGADFFFSYLKENQLILPAHKKIAAVGEKTARRLKMHNVSVDVMPQEYIAEQLADALKQHAEPGETITVMKGNLSRDVIKQELVPLGFEVKEWVLYETIPDEEGIEALKDAAGQYSFDYVTFTSSSTVHTFMHVLGEELKKWKANGTACISIGPLTNDALLTYGITSHTPDTFTIDGMLELMCSMSREEERI
Protein
Uroporphyrinogen-III synthase: hemD

Gene
hemD
Protein
Putative uroporphyrinogen-III synthase
Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)
Length
253 amino acids
Function
Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
Similarity
Belongs to the uroporphyrinogen-III synthase family.
Mass
27.462 kDa
Sequence
MAVTRPPERSAEAVELIEGAGGRALVAPTLELKEAHTESLREVCRRADEWDLVIFTSQAAVESLFQLCREFAGKIRKDCLVAVIGPRTARVAGEHGLRVDIVPEDYTAEGLLDALTGLNIEGWKVALPRTLSARKVLPRGLEMMGAEVLVAEAYRSGLPEDTGPAEELIDGLLDGKVDAVTFTSPLTVENLFKIAGNRRKELIEVLKRVKVAAIGPITLRKLEEHGITAVTPERYTVKDMIAALAVSMGEDVD
Protein
Putative uroporphyrinogen-III synthase: hemD

Gene
hemD
Protein
Uroporphyrinogen-III synthase
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Length
251 amino acids
Function
Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
Similarity
Belongs to the uroporphyrinogen-III synthase family.
Mass
27.279 kDa
Sequence
MSGWRLLLTRPDEECAALAASLGEAGVHSSSLPLLAIDPLEETPEQRTLMLDLDRYCAVVVVSKPAARLGLERLDRYWPQPPQQTWCSVGAATAAILEAYGLDVTYPEQGDDSEALLALPAFQDSLRVHDPKVLIMRGEGGREFLAERLRGQGVQVDYLPLYRRRAPDYPAGELLARVRAERLNGLVVSSGQGLQNLYQLAAADWPEIGRLPLFVPSPRVAEMARELGAQRVIDCRGASAPALLAALTSAA
Protein
Uroporphyrinogen-III synthase: hemD

Gene
hemD
Protein
Uroporphyrinogen-III synthase
Organism
Chlorobaculum parvum (strain NCIB 8327)
Length
246 amino acids
Function
Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
Similarity
Belongs to the uroporphyrinogen-III synthase family.
Mass
26.786 kDa
Sequence
MKTVLVTRPKHQAAPFVRELEQYGLSTVVFPTIEIRPVAGWNVPDLTKFAGIFFTSPNSVQFFLKHLLQTAPDELKNLQQTRVWAVGKTTGQDLEKHGVSIEPLPKIADAVNLMADIDPAEIKGQTFLFVRGSLSLGTIPELIAEFGGTCVELTVYENLPPSLEDTQRVKDMLAEGKLDCLSFTSPSTAKNFFEAIGSKELSDSVQIAAIGTTTSGALEKMGIKVDIIPEYFDGPSFAKAIAEALK
Protein
Uroporphyrinogen-III synthase: hemD

Gene
hemD
Protein
Uroporphyrinogen-III synthase
Organism
Chlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS)
Length
246 amino acids
Function
Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
Similarity
Belongs to the uroporphyrinogen-III synthase family.
Mass
26.616 kDa
Sequence
MKTVLVTRPKHQAEPFVRELAQYGLDSVVFPTIEIRPVTGWSVPDLTRFAGIFFTSPNSVQFFLERLLEESPDELPNLQQARVWAVGKTTGGDLEKHGVSIEPLPKSADAVSLMSGIDASEIEGKTFLFVRGSLSLGTIPEVIAKRGGICVELTVYDNIQPSLEETQKIKSLLTEGKIDCLSFTSPSTAINFFEAIDSKEVPSDVLIAAIGTTTSSALEKLGVKVDIIPEYFDGPNFAKAIAAALS
Protein
Uroporphyrinogen-III synthase: hemD

Gene
hemD
Protein
Uroporphyrinogen-III synthase
Organism
Escherichia coli (strain K12)
Length
246 amino acids
Function
Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
Similarity
Belongs to the uroporphyrinogen-III synthase family.
Mass
27.798 kDa
Sequence
MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDALLRALQ
Protein
Uroporphyrinogen-III synthase: hemD

Gene
hemD
Protein
Uroporphyrinogen-III synthase
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Length
246 amino acids
Function
Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
Similarity
Belongs to the uroporphyrinogen-III synthase family.
Mass
27.662 kDa
Sequence
MSILITRPSPAGEALVSRLRALGQVAWSFPLIEFVAGRELPTLADRLATLTENDLVFALSQHAVAFAHAQLQRDGRNWPVAPRYFAIGRTTALALHTVSGFDIRYPLDREISEALLQLPELQNIAGKRALILRGNGGRELLGETLTARGAEVSFCECYQRCAKHYDGAEEAMRWHTRGVTTLVVTSGEMLQRLWSLTPQWYREHWLLRCRLLVVSERLAHLARELGWQDIKVADNADNDALLRALQ
Protein
Uroporphyrinogen-III synthase: hemD

Gene
hemD
Protein
Putative uroporphyrinogen-III synthase
Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
Length
240 amino acids
Function
Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
Similarity
Belongs to the uroporphyrinogen-III synthase family.
Mass
27.614 kDa
Sequence
MKVVITRPKERADVFASLLKKEGFEPIIFPTLEIVYNKDLDVNLDSYDWIAFTSPSGVIGLYNILTENERENVKNKKIAVIGEKTAKTFKKYFGRDPDIMPNEYTAESLLREIKKVSKEEEKFLIPTTPSTRDVLKNNLNADLLFVYKSAEPENLKEDIKKLKELIAKDKFILTFTSGLTAKNFFKYVDDEFAEIIKDNYIVAIGPITAKVIEKFGFKPLIPKVYTIEGMLEVIRTLKER
Protein
Putative uroporphyrinogen-III synthase: hemD

Gene
hemD
Protein
Uroporphyrinogen-III synthase
Organism
Proteus mirabilis
Length
199 amino acids
Function
Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
Similarity
Belongs to the uroporphyrinogen-III synthase family.
Mass
22.799 kDa
Sequence
MSILITRPSPAGEQLTQRLIDAGKHAFHAPLIEIAAGKELSILENKLNKLSTGDYLFLLSKNAVWYANWQLNQLQQSWPDTLFYYGIGQSTAEEFQQLTAHSIRYPEFGETSEDLLALSSLQQIENKRVLLLRGNGGRELLATTLRQRGAIVDECECYQRLFIDYVSEEFALKWKNAQVEYLCGHQCEMLQQLLSSRWI
Protein
Uroporphyrinogen-III synthase: hemD