hem1

Gene

hem1

Protein

5-aminolevulinate synthase, mitochondrial

Organism

Agaricus bisporus

Length

621 amino acids

Function

Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis.

Similarity

Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

Mass

67.426 kDa

Sequence

MSHHGPRLSTRSQQIVAGYASVAANFDVEKLHREQGVNIPTSGASINQCPHAAAARAAARMADDLASAARAKKSLDAKGSLAGRPVHHKAATESTKAKHTGFDYEAFYKGELAKKHQDKSYRYFNNINRLARKFPVAHTANPRDEVEVWCSNDYLGMGNNPVVLETMHRTLDKYGHGAGGTRNIAGNGAMHLGLERELRLHRKEAALVFSSCYVANDATLSTLGTKLPGCVIFSDTMNHASMIQGMRHSTPKRVIFKHNDLEDLETKLQQYPKETPKIIAFESVYSMCGSIGPVKEICDLAEQYGAITFLDEVHAVGLYGPRGAGVAEHLDYDAHLAAGSSPDPIPGSVMDRIDIITGTLGKSYGAVGGYIAGSEEFVDMIRSYAPGFIFTTSLPPATVAGARASIVYQSEYLGDRQLKQINVREVKRRLAELDIPVVPGSSHIVPVLVGDAALARAASDKLLSEHDIYVQAINYPTVARGEERLRITVTPRHTMEQMEGLIRSLNQVFEELNINRLSDWKLAGGRAGVGIPGAADDVQPIWTDEQIGLLNGTAPRSLRNAEKSVVDMRAVTIARSRFDVLLGPVYGELQPTEDFDTPAVGATFKAPLVDREVAHDITVSA

Protein

5-aminolevulinate synthase, mitochondrial: hem1

Gene

HEM1

Protein

5-aminolevulinate synthase, mitochondrial

Organism

Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968)

Length

575 amino acids

Function

Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis.

Similarity

Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

Mass

62.652 kDa

Sequence

MESITRVSMSVCPFVKSSSAQALRQLSKNSALTSQARQCPFMGAALNAKESTRSYSSATKPVRATASSLASNPPSTMQSKYSFKAEELVGNKDAINLESKENTFDFKGYLNSELSKKRTDKSYRFFNNINRLANEFPKAHRSEENDKVTVWCSNDYLGMGKNENTINEMKRVLTKYGSGAGGTRNIAGHNIHALKLESELAALHKHEAALVFSSCFVANDAVLSLFGQKIKDLVIFSDELNHASMIQGIRNSRAKKQVFKHNDLADLEEKLAQYPKSTPKLIAFESVYSMCGSIAPIEAICDLAEKYGALTFLDEVHAVGMYGPHGAGVAEHLDFDAHLKSGIASPQTQTVMNRVDMVTGTLGKAYGTVGGYITGKANLIDWFRSFAPGFIFTTTLPPSIMAGSSASIRYQRSTLQDRIAQQTNTRYVKNNLTDIGIPVIPNPSHIVPVLVGNALDAKKASDLLLDKYNIYVQAINFPTVPIGQERLRITPTPGHGPELSNQLIGALDSVFNELSLSRIGDWEGKGGLCGVGEPDIEPIEHIWTSEQLALTDADINPNVIDPVIQPIGVSSGVRD

Protein

5-aminolevulinate synthase, mitochondrial: HEM1

Gene

HEM1

Protein

5-aminolevulinate synthase, mitochondrial

Organism

Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968)

Length

575 amino acids

Function

Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis.

Similarity

Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

Mass

62.652 kDa

Sequence

Protein

5-aminolevulinate synthase, mitochondrial: HEM1

Gene

HEM1

Protein

5-aminolevulinate synthase, mitochondrial

Organism

Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)

Length

570 amino acids

Function

Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis.

Similarity

Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

Mass

62.139 kDa

Sequence

MESVIRSSAKICPFMHSATGSMQSVKALKNANLPAIAQQCPFMGKAMEQRRGYASSASGASAAAAATATASTSASNSNSSVEASASADVVDHATKEASFDYQGLFDSDLAKKRMDKSYRFFNNINRLAKEFPMAHRKLEDDKVTVWCSNDYLALSKNQEVIEVMKKTLDKYGAGAGGTRNIAGHNKHALQLEAELATLHKKEGALVFSSCFVANDAVISLLGQKIKDLVIFSDELNHASMIVGIKHASTKKHIFKHNNLDQLEELLAMYPKSTPKLIAFESVYSMSGSVADIDKICDLAEKYGALTFLDEVHAVGLYGPHGAGVAEHCNFDAHRKAGIASPEFRTVMDRVDMITGTLGKSFGTVGGYVAGSLQLIDWVRSYAPGFIFTTTLPPAVMAGAAEAIRYQRSHLDLRQDQQRHTTYVKDGLADLGIPVMPNPSHIVPVLVGNPHLAKQASDILMDKHRIYVQAINFPTVARGTERLRITPTPGHTNDLSDILMDALEDVWSTLQLPRVRDWEAQGGLLGVGDPNHVPQPNLWTKDQLTLTNNDLHPNVKQPIIEQLEVSSGIRY

Protein

5-aminolevulinate synthase, mitochondrial: HEM1

Gene

HEM1

Protein

5-aminolevulinate synthase, mitochondrial

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876)

Length

564 amino acids

Function

Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis.

Similarity

Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

Mass

61.381 kDa

Sequence

MESITKVSMSVCPFVRSTSTQALRQLSQTSGALANQARQCPIAGNAIRAKEISIRSYSSATKPARATAATPSTPEATFNVTSSFELGSKETAFDYNGYLGNELEKKRSDKSYRYFNNINRLANEFPKAHRTQEEDKVTVWCSNDYLGMGKNENTLKEMKRVLDKYGSGAGGTRNIAGHNSHAIKLESELAALHKHDAALVFSSCFVANDAVLSLLGQKIKDLVIFSDELNHASMIQGIRNSRARKHIFKHNNLADLESKLAQYPKSTPKLIAFESVYSMCGSIAPIEAICDLAEKYGALTFLDEVHAVGMYGPHGAGVAEHLNFEAHLKSGIERPEITTVMSRVDMVTGTLGKAYGVVGGYITGKTNLIDWFRSYAPGFIFTTSLPPAIMAGCSASIRYQRATLKDRIAQQKNTRLVKNNLNELGIPVIPNPSHIVPVLVGNAADAKRASDLLLNKHDIYVQAINFPTVPIGEERLRITPTPGHGPELSKQLVEAVDSVFTELNLNRINDWKKLGGLVGVGVEGAAKVEHIWTEEQLALTDADLNPNVVNPAISPLDVSSGIST

Protein

5-aminolevulinate synthase, mitochondrial: HEM1

Gene

hem1

Protein

5-aminolevulinate synthase, mitochondrial

Organism

Schizosaccharomyces pombe (strain 972 / ATCC 24843)

Length

558 amino acids

Function

Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis.

Similarity

Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

Mass

60.96 kDa

Sequence

MERVVKLAAKHCPFVSKADPSALRRMAGAGLIRAGARCPVVRHALPVAAATGADVSRGFKSDSKQMAMEPSLDEIHLKAGVVNTGSRTCRHADAVKAAAEAATTTPVTKKHQMPKHYASDLNGVGPATTPRFDYDTFYREELDKKHRDKSYRYFNNINRLAKEYPLAHLADPNTRVEVWCSNDYLNMGGHKKIREAMHQCIETYGGGAGGTRNIAGHNQHAVRLEKSLADLHQKPAALVFGSCYVANDATLSTLGRKLPNCIFLSDEMNHASMINGIRNSRCEKIIFKHNDLVDLEAKLASLPLNRPKIIAFESVYSMSGNVAPISEICDLAKKYGAITFLDEVHAVGMYGPRGAGVAEETPGLLSRVDIITGTLAKSYGCVGGYIAASSTLVDMIRSLAPGFIFTTSLPPHVMVGALTAVEHLKVSNVEREQQRSAVRRVKQSLSEIGIPVLSNDTHIVPAMVGDAHLAKLASDSLLHDHNIYVQSINFPTVSVGTERLRITPTPAHNTEHYVQSLTNAMNDVWSKFNINRIDGWEKRGIDVGRLCKFPVLPFTTTH

Protein

5-aminolevulinate synthase, mitochondrial: hem1

Gene

HEM1

Protein

5-aminolevulinate synthase, mitochondrial

Organism

Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)

Length

556 amino acids

Function

Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis.

Similarity

Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

Mass

61.222 kDa

Sequence

MDSLARQSAKICPFVSRVTSSMQQVQVLHKTNMSAMAQQCPVMRRAMAARGYVTASPPAGAAAADVGEARPITPVLERGTQERTFDYDGLFETELQKKRLDSSYRFFNNINRLAKEYPMAHRLEEEDKVTVWCSNDYLTYSRNEKVMETMKRTIDKYGAGAGGTRNIAGHNRHAMRLEAELAALHKKEGALVFSSCFVANDAVLSLLGQKMPNMVIFSDEMNHASMIMGIKHANVQKHIFRHNDLQHLEELLAMYPKSQPKLIAFESVYSMSGSVADIRKICDLAEKYGALTFLDEVHSVGLYGPHGAGVAEHLDFEAHRKAGLASPAQTTVLDRVDMITATLGKSFGSVGGYLAASEKLVDFVRSYAPGFIFTSSLPPAVMAGSAAAVFDQRSSLHLRQLQQKHTSYVKTGLGDLGIPVQPNPSHIVPVLVGNPDLAKRASDILMEKHRIYVQAINFPTVPRGTERLRITPTPGHTNDLSDVLLDAMDDVWKTLQLPRVSDWAAHGGLLGVGEPDYVPEANLWTEEQMSLTNDDLHPSVFSPVEKFLEVSSGIKA

Protein

5-aminolevulinate synthase, mitochondrial: HEM1

Gene

HEM1

Protein

5-aminolevulinate synthase, mitochondrial

Organism

Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)

Length

530 amino acids

Function

Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis.

Similarity

Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

Mass

58.385 kDa

Sequence

MFRPVLKVRPSFSYPYSIVSSRSVRLASTATANANTAAATSTVAAHGTQETPFDFEGHFESELAKKRLDKSYRYFNNINRLAKEFPLAHRQLEDDKVTVWCSNDYLALSKNPQVLDAMRKTIDKYGAGAGGTRNIAGHNIPTMRLEAELAALHKKEGALVFSSCYVANDAVISLLGQKVKDLVIFSDELNHASMIVGIKHANRPKHIFRHNDLAQLEEMLQMYPKSTPKLIAFESVYSMAGSVADINKICDLAEKYGALTFLDEVHAVGLYGPHGAGVAEHCDFEAHRVAGIATPPQGDNGRLRTVMDRVDMITGTLGKSFGTVGGYVAASSKLIDWVRSYAPGFIFTTTLPPAVMAGAAEAIRFQRSHLNLRQDQQRHTAYVKKGLHDLGIPVIPNPSHIVPVLIGNPDLAKQASDILMEKHRIYVQAINFPTVSRGTERLRITPTPGHTNDLSDILIAAVDDVFNELQLPRIRDWEMQGGLLGVGDKNFVPEPNLWTEEQLSFSNEDLNSNVFEPVIDQLEVSSGVKL

Protein

5-aminolevulinate synthase, mitochondrial: HEM1