Protein
Dihydromethanophenazine:CoB--CoM heterodisulfide reductase subunit D
Organism
Methanosarcina thermophila (strain ATCC 43570 / DSM 1825 / OCM 12 / VKM B-1830 / TM-1)
Function
Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B) (PubMed:9654152, PubMed:9665708, PubMed:11034998). Electrons probably transfer from phenazine to the high potential 4Fe cluster in HdrD subunit, then to the low potential heme in HdrE subunit and finally to CoM-S-S-CoB (PubMed:11034998).
Similarity
Belongs to the HdrD family.
Sequence
MAKRNPSIDTKNLTAVQLMELDACVRCGECVKWCPTYAASGEKPGLAPRDKILRWRQYMNKSYGLKARLFGPQEIPISELEEFKDDVHGCTTCGICSTVCEAGINTVELWESMRANLVKKGIGPYGKQNMFPKLIGQYRNPYMKDQKDRLAWVPPDVKIEDKADIVYFTGCTAGYNQLALAFATSRVLNKLGIKFAMLGEDEWCCGSALIRTGQAHINNVPYELAKHNVEAIQKKGAKKVLFACAGCFRAAKVDWPRLLGKELPFEVVHVSEFLAGLIKEGKIKWEKSINKTVTYHDPCHLGRHVGVFDAPRYVLSHIPGVKFVEMDRIKEFQRCCGAGGGVKAGLPDLAMAVAESRVKDALDTKADILSSCCPFCKRNLMDGRDSLKVDLVVEDVIELVAEALNLETK