Protein
7-alpha-hydroxysteroid dehydrogenase
Organism
Escherichia coli (strain K12)
Function
Catalyzes the oxidation of the 7-alpha-hydroxy group of primary bile acids such as cholate, chenodeoxycholate and taurochenodeoxycholate (PubMed:2007545, PubMed:9722677). To a lesser extent, also able to use taurocholate and glycocholate (PubMed:2007545).
Similarity
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Sequence
MFNSDNLRLDGKCAIITGAGAGIGKEIAITFATAGASVVVSDINADAANHVVDEIQQLGGQAFACRCDITSEQELSALADFAISKLGKVDILVNNAGGGGPKPFDMPMADFRRAYELNVFSFFHLSQLVAPEMEKNGGGVILTITSMAAENKNINMTSYASSKAAASHLVRNMAFDLGEKNIRVNGIAPGAILTDALKSVITPEIEQKMLQHTPIRRLGQPQDIANAALFLCSPAASWVSGQILTVSGGGVQELN