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hcp-3

Gene
hcp-3
Protein
Histone H3-like centromeric protein hcp-3
Organism
Caenorhabditis elegans
Length
288 amino acids
Function
Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore (PubMed:10524621). Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation (PubMed:11402065, PubMed:14522947, PubMed:16273096, PubMed:16950114, PubMed:16950115). May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By similarity). Might promote cleavage furrow stability during cytokinesis (PubMed:23684975). Not required for chromosome segregation during meiosis (PubMed:16273096).
Similarity
Belongs to the histone H3 family.
Mass
32.997 kDa
Sequence
MADDTPIIEEIAEQNESVTRIMQRLKHDMQRVTSVPGFNTSAAGVNDLIDILNQYKKELEDDAANDYTEAHIHKIRLVTGKRNQYVLKLKQAEDEYHARKEQARRRASSMDFTVGRNSTNLVDYSHGRHHMPSYRRHDSSDEENYSMDGTNGDGNRAGPSNPDRGNRTGPSSSDRVRMRAGRNRVTKTRRYRPGQKALEEIRKYQKTEDLLIQKAPFARLVREIMQTSTPFGADCRIRSDAISALQEAAEAFLVEMFEGSSLISTHAKRVTLMTTDIQLYRRLCLRHL