Protein
Histone H3-like centromeric protein hH3v
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Function
Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By similarity).
Similarity
Belongs to the histone H3 family.
Sequence
MPPKKGGVTKSKAVSKKAAAVPTPKATPPGRRKSRASSVQPGDPVPQGKKRRYRPGTLALKEIRNYQRTTDLLVAKLPFARLVREIAMQFRPMDEEMRWQSQAILALQEAAEAFLVHLFEDTNLCAIHAKRVTIMQKDIQLARRIRGVWGGAGWV