GSP

Glutathionylspermidine synthase

719 amino acids

Conjugates glutathione (gamma-Glu-Cys-Gly) and spermidine to form glutathionylspermidine in the biosynthesis trypanothione (N(1),N(8)-bis(glutathionyl)spermidine), which is involved in maintaining intracellular thiol redox and in defense against oxidants.

In the C-terminal section; belongs to the glutathionylspermidine synthase preATP-grasp family.

80.322 kDa

MSSLPHNHHYETHHRGTAEVPFDELIGVTPDGVPVISNGNEAHFSNLESITAACLPLSSFERKAPCKQPYRKMGVKWQCVEFVRRYLASRKAVWMTSLCTAEEVWREENLFVDVRDGRPVEVVRTPNKSTGPAPAVADIVVWGEGPETPFGHVAIVTEVCASCVRVAEQNQGFEKWPEDVPFSREIAMRTTESGEVELLDEDPLLGWVTVQAPFYNFDDGDLADSFRLVVGQGQILRQPFPKHVDVPWLNTGEECDTILKHSLVVDGNMGEGAHAEEGDVPGAFYFLDYDMFCRLGRAASSLHRIAMAATAKVLEDPESTHLLEHYFGVPPEIQPLLRRSWEMTPPMGGRFDFGYDGKNVVMLEYNCDSSGALLECCNTQEKMARFYGVSQGTSTGSFLGAKCVTYFQRLLTNEKVCPQHRLIHFMIDEDDEERYTARCMMGFAEQAGFRTKLCVKLVNFRYRDGPPSNAAPLATPCDHPTIVDGEDEEVLMVWKTWSWDTVLHQYHSQRSSSDAVNTPTLSDILLNNNIRVLEPLWKAVTGSKAILPFMHALAPDHEHMLAASFLPTREIISRHYISKPVNGRAGQNIMMYDPVTSPTELEGAPQQDICEALSQNASARSLLNGSPLPLSQSVDQTNECSPGKFFDSVLVYQQRLFLKKFDGKYFPIFCGWMVGDEFGGVVVREDTSKITKLSSMVVPARVVRDNVPLGVSYSDEGET

gsp

4'-phosphopantetheinyl transferase gsp

237 amino acids

Activates the five peptidyl carrier protein (PCP) domains of gramicidin synthase GrsAB, by transferring the 4'-phosphopantetheinyl moiety of coenzyme A (CoA) to a serine residue. Required for gramicidin S production.

Belongs to the P-Pant transferase superfamily. Gsp/Sfp/HetI/AcpT family.

27.857 kDa

MIEMLFVKVPNEIDRHVFNFLSSNVSKEKQQAFVRYVNVKDAYRSLLGELLIRKYLIQVLNIPNENILFRKNEYGKPFVDFDIHFNISHSDEWVVCAISNHPVGIDIERISEIDIKIAEQFFHENEYIWLQSKAQNSQVSSFFELWTIKESYIKAIGKGMYIPINSFWIDKNQTQTVIYKQNKKEPVTIYEPELFEGYKCSCCSLFSSVTNLSITKLQVQELCNLFLDSTFSENNNF