Protein
Histone-lysine N-methyltransferase, H3 lysine-79 specific
Organism
Drosophila melanogaster
Function
Histone methyltransferase. Methylates 'Lys-79' of histone H3. Required for Polycomb Group (PcG) and trithorax Group (trxG) maintenance of expression. Also involved in telomeric silencing but do not in centric heterochromatin. Probably participates in pairing sensitivity.
Similarity
Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.
Sequence
MATPQVKDLVLRSPAGSSDVISFAWPLQIGHGQDKHDNGIDIIDTIKFVCDELPSMSSAFEETNLHQIDTACYKTMTGLVDRFNKAVDSIVALEKGTSLPAERLNKFAHPSLLRHILQLVYNAAVLDPDKLNQYEPFSPEVYGETSYELVQQMLKHVTVSKEDTFIDLGSGVGQVVLQMAGSFPLKTCIGIEKADTPARYAERMDVIFRQYMGWFGKRFCEYKLIKGDFLVDEHRENITSSTLVFVNNFAFGPTVDHQLKERFADLRDGARVVSSKSFCPLNFRITDRNLSDIGTIMHVSEIPPLKGSVSWTCKPVSYYLHVIDRTILERYFQRLKTKGGNDHESVGTVRTTRDRAKREANVGQHHHNNHHSNNHANSNNHQRDREQSNGATATAAHQQRHQSQSPANVSGAGIVLAASGQQAASKTRQQLQHQHNQQQRSLDMESSTESDGDATNGNGGNTTTATNTTSASNGPMTRKVWSDWCSSKGKSSQSDDEENNNSNSNGGSNGGSIGGGSVGRQARATTQKKRKKLTRKAAIASKSAAAAQREAEAAAAAAVSVPSKESSSKEDPPRAASAGPGRKGRMKKGARGRKSLKIVGLEALHKQTVLSTSLDTMTKKLPAAPGTVDQQLTALLTENMSHAELDIPTAPQDTPYALQILLDVFRSQYTSMIEHMKSSAYVPQVQKQIAQEQERMARLKNRASQLDKQIKVLIDDSVALLKVRMNELGIHVNSPNDLIAQAKEIVGRHKDLQHTASRMRNEVTFYEGEQKLLLNKQLKNLPEYQKLCGTVNGKVKLEVPPELSETTAQELVLKEIANTLSQRKKLYAQVSTIEQETSVLQKTAEERSTAATLLAQGTNMIVSTGSSSSSSTTVCASAVTAQSNKLNSVKNSRRNREHRARSQEWPEVPEVGKIQESNPEVLAQKIVETCRQIEAGKFQGAGAPSSQVNGKNKAIIEVPPPPATAPVSIKSSPGHHYKDTTLMPAPKQQQQQQMTLSQLPKCELPGLSTSRKQESPKVANFEDRLKSIITTALNEDQEQRSKAVESSPSPSPLHSPAPKRSKQHPAGAINPAQSLPNNLHNIITVSTQGLMHLNANTTISPITPPLPGPGAGATASTAPPPPANLPYGAYGGAVAKTTISGKYQAAKEPKYSPVRQAPLPPPPSHMASLYPAGQQTTPADLGYQRRRSSVSATSYEHYMVQQQQQLQQQQLMLAAAAHAAQRQQMRVEEQQQQQQHQHHHHHHHHHPQHRLPQHVQHQHPHQHHPNEFKAPPADSHLQRSSSREQLIVEPPQTQPLELLPRASSANSDYSGYRIRPPSRPSSNSSQPDYTQVSPAKMALRRHLSQEKLSQHVTPQATPPLPGHGGAPTSGKTIGDLVNGEIERTLEISHQSIINAAVNMSTSGASFMERAFLNERSNDRLLINLNAQRPERVHVRPLSEESQDPQPTSYAQERGPGLGAGGAAAGGNSNLATLAHVAYAQKAQGGARANAGTAPPATHSSSARSGRDYQPVALPRAELKGSIEAYFHEEQQQKQSKGAGSAGSSSLRGPRLNGANPPLEGLAASLQDHVRARKYKEETEERQRRAAAAASSSAGPPAGMELPTHYAHQAPPAHSYHHHGASINGTPHKVELGIKRSSPLAPHQQPPRPSKLAHYEPPTTQQQHAHAHLYANGQVLPPPPAHDATTPSPTPSSSSSSCGRRSNSNNGKLLVDPPLLMSPEINSLLGDERPLQLSHHQQQQQQMLHHHQSQQQQHLQLTQQQLRVAHLGHGLSHGHSTMPTLGGQRNGNGNAADDVNDLATQRTITNYDPRRRLRTTLSGPTKLSAAHSNQNLNGYVMADSSSSCPTIPQ