gpaI

Guanine nucleotide-binding protein alpha-9 subunit

342 amino acids

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G alpha-9 antagonizes broad chemotactic response. It functions rapidly following receptor stimulation to negatively regulate PI3K/PTEN, adenylyl cyclase, and guanylyl cyclase pathways.

Belongs to the G-alpha family.

39.66 kDa

MGCNSSSEAKQSDKIDRTLYDEKKSQEREIKLLLLGSGDSGKSTIAKQMRYIHTKGFSNEEIATFVEIMHSNVLSSIQILIRNVPVEQLGSDLKDKANYYSSINPYELPLTPDIGLEIDRLWKNEAIQKLFSTNRAELNLPEVTAYCLDQVERISSETYTPTQEDVLRCRQRTTGMKETQFNVEDIKFRLIDVGGQKNERRKWMHYFEDVKSIIFCVALGDYDMNLVEDETINRMEDSLKLWNDIVNNPFFKNTSFVLFLNKNDIFREKIKKIPLVDYFPDYQGGYNYEKGIEYIRNKFFSSVPTATTIVAHVTTATDTENITIVFDAVRRNIIQSILKLHY