About Products Protein Database Contact

glyA1

Gene
glyA1
Protein
Serine hydroxymethyltransferase 1
Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Length
438 amino acids
Function
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules (By similarity).
Similarity
Belongs to the SHMT family.
Mass
46.188 kDa
Sequence
MTAAPDARTTAVMSAPLAEVDPDIAELLAKELGRQRDTLEMIASENFAPRAVLQAQGSVLTNKYAEGLPGRRYYGGCEHVDVVENLARDRAKALFGAEFANVQPHSGAQANAAVLHALMSPGERLLGLDLANGGHLTHGMRLNFSGKLYENGFYGVDPATHLIDMDAVRATALEFRPKVIIAGWSAYPRVLDFAAFRSIADEVGAKLLVDMAHFAGLVAAGLHPSPVPHADVVSTTVHKTLGGGRSGLIVGKQQYAKAINSAVFPGQQGGPLMHVIAGKAVALKIAATPEFADRQRRTLSGARIIADRLMAPDVAKAGVSVVSGGTDVHLVLVDLRDSPLDGQAAEDLLHEVGITVNRNAVPNDPRPPMVTSGLRIGTPALATRGFGDTEFTEVADIIATALATGSSVDVSALKDRATRLARAFPLYDGLEEWSLVGR

Gene
glyA1
Protein
Serine hydroxymethyltransferase 1
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Length
438 amino acids
Function
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. Thus, is able to catalyze the cleavage of L-allo-threonine.
Similarity
Belongs to the SHMT family.
Mass
46.216 kDa
Sequence
MTAAPDARTTAVMSAPLAEVDPDIAELLAKELGRQRDTLEMIASENFVPRAVLQAQGSVLTNKYAEGLPGRRYYGGCEHVDVVENLARDRAKALFGAEFANVQPHSGAQANAAVLHALMSPGERLLGLDLANGGHLTHGMRLNFSGKLYENGFYGVDPATHLIDMDAVRATALEFRPKVIIAGWSAYPRVLDFAAFRSIADEVGAKLLVDMAHFAGLVAAGLHPSPVPHADVVSTTVHKTLGGGRSGLIVGKQQYAKAINSAVFPGQQGGPLMHVIAGKAVALKIAATPEFADRQRRTLSGARIIADRLMAPDVAKAGVSVVSGGTDVHLVLVDLRDSPLDGQAAEDLLHEVGITVNRNAVPNDPRPPMVTSGLRIGTPALATRGFGDTEFTEVADIIATALATGSSVDVSALKDRATRLARAFPLYDGLEEWSLVGR

Gene
glyA1
Protein
Serine hydroxymethyltransferase 1
Organism
Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099)
Length
437 amino acids
Function
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
Similarity
Belongs to the SHMT family.
Mass
46.769 kDa
Sequence
MATAAAASNKFESFFETTLEDADPEIFGAIRNELGRQRHEIELIASENIVSRAVLEAQGSIMTNKYAEGYPGKRYYGGCQFVDVAEELAIERAKKLFGCNFANVQPNSGSQMNQAVFLALLQPGDTFMGLDLNSGGHLTHGSPVNMSGKWFKVVSYGVRKEDHLLDMDAIEKTAHETKPKLILAGGTAYSRIWDWKRFREIADAVGAYLMVDMAHIAGLVAGGVHPSPLPHAHVVTTTTHKSLRGPRGGMILCNDEDIAKKMNSAVFPGLQGGPLMHVIAAKAVAFGEALKPSFKVYAESVAANAKALASSLKETGLDIVSGGTDNHLMLVDLRPKNATGKRAEAALGRANITCNKNGIPFDPEKPFVTSGVRLGTPAGTTRGFGQAEFREIGKLIAEVLDGLKIANSDEGNAAVEAAVKAKVVALTDRFPLYPYLG

Gene
glyA1
Protein
Serine hydroxymethyltransferase 1
Organism
Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIB 8255 / S1)
Length
434 amino acids
Function
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
Similarity
Belongs to the SHMT family.
Mass
45.849 kDa
Sequence
MEASVAPPALRNAPCAGVNAACLSAADDAVAIAIAQETTRQRESIELIASENFVSKAVLEAQGSVLTNKYAEGYPQRRYYGGCANVDRVEDLAIARLNQLFGSTYANVQPHSGSQANQAVFLALLAPGDTILGLDLKAGGHLTHGAPVNISGRWFTAVSYGVDPRTHLIDMEQMADLARRHRPKLLIAGGSAYPRLLDFARFRQIADEVGAILMVDMAHFAGLVAGGVYPSPVPFADVITSTTHKTLRGPRGGFVLTNDAAIAKKINSAVFPGLQGGPLMHIIAAKAVAFGEALDPSFKIYARRVVENCRVLAQTLLDGGLAITSGGTDCHLAVVDLRPLGVTGTIAEQALESIGITLNKNAIPNDPEKPMVTSGIRVGSAAGTSRGFGPEEYRRIAALILETLHAVRAGTLEADREGIRTRVRSLVAGFPLPY

Gene
glyA1
Protein
Serine hydroxymethyltransferase 1
Organism
Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
Length
432 amino acids
Function
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
Similarity
Belongs to the SHMT family.
Mass
46.185 kDa
Sequence
MSTANPASAPDSFFSASLEQADPEIAAAIRGELGRQRHEVELIASENIVSRAVLEAQGSVMTNKYAEGYPGNRYYGGCEFVDVAENLAIDRAKKLFGANFANVQPNSGSQMNQAVFLALLQPGDTFMGLDLAAGGHLTHGAPVNMSGKWFKPVHYTVRREDQMIDMDAVAKLAEEAKPKLIIAGGSAYPRAWDFKRFREIADSVGAYFMVDMAHFAGLVAGGVHASPVPHAHVTTTTTHKSLRGPRGGLILTNDEALAKKFNSAIFPGLQGGPLMHVIAAKAVAFKEALQPDFKVYTKNVVENAKALAETLRSAGFDLVSGGTDNHLMLVDLRPKGLKGNVSEKALVRAGITCNKNGIPFDPEKPFVTSGLRLGTPAATTRGFGVAEFQQVGHLIAEVLNAIAQSSDGAAPLVEASVKQRVKELTDRFPIYQ

Gene
glyA1
Protein
Serine hydroxymethyltransferase 1
Organism
Rhizobium meliloti (strain 1021)
Length
431 amino acids
Function
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
Similarity
Belongs to the SHMT family.
Mass
46.732 kDa
Sequence
MLSQTNDAFFTRSLADSDPEIFGAIEKELGRQRHEIELIASENIVSRAVLEAQGSIMTNKYAEGYPGKRYYGGCQYVDIAEALAIERAKKLFGVNFANVQPNSGSQMNQAVFLALLQPGDTFMGLDLNSGGHLTHGSPVNMSGKWFNVVSYGVREDDHLLDMDEVARKAREQKPKLIIAGGTAYSRIWDWKRFREIADEVGAWLMVDMAHIAGLVAGGQHPSPFPHCHVATTTTHKSLRGPRGGMILTNDEEIAKKINSAVFPGLQGGPLMHVIAAKAVALGEALQPSFKDYAAQVVKNARTLAETLKANGLDIVSGGTDNHLMLVDLRKKNATGKRAEAALGRAYVTCNKNGIPFDPEKPFVTSGVRLGAPAGTTRGFKEAEFKEVGELIVEVLDGLKAANSDEGNAAVEAGVREKVIKLTDRFPMYGYM

Gene
glyA1
Protein
Serine hydroxymethyltransferase
Organism
Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3)
Length
431 amino acids
Function
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
Similarity
Belongs to the SHMT family.
Mass
46.162 kDa
Sequence
MNASHQDTGFFTEALSERDPELFGAITSELGRQRDEIELIASENIVSAAVMQAQGSVMTNKYAEGYPGRRYYGGCQYVDIAENLAIERAKQLFGCGFANVQPNSGSQANQGVFQALIKPGDTILGMSLDAGGHLTHGAAPNQSGKWFNAVQYGVRQQDNLLDYDQVEALAKEHRPKLIIAGGSAIPRQIDFARMREIADMVGAYLHVDMAHFAGLVAAGEHPSPFPHAHVATTTTHKTLRGPRGGMILTNDEDIAKKVNSAIFPGIQGGPLMHVIAAKAVAFGEALRPEFKTYIQQVIANAQALSDQLIKGGLDTVTHGTDTHVVLVDLRPKGVKGNATEKALGRAHITCNKNGVPFDPEKPTVTSGIRLGSPAGTTRGFAETEFRQIADWIIEVVDGLAANGEDANEAVEDKVKAQVAALCAKFPIYPNL

Gene
glyA1
Protein
Serine hydroxymethyltransferase 1
Organism
Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50)
Length
430 amino acids
Function
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
Similarity
Belongs to the SHMT family.
Mass
45.219 kDa
Sequence
MNDLLPAAAAPAGARALPLRHADPEIWRAVDAERQRQMHSIELIASENFVSQAVLDAQGSVMTNKYAEGYPGRRYYGGCRHVDVAERAAIERARRLFGCEYANVQPHSGSQANQAVYLALLAPGDRILGLDLKAGGHLTHGAHVNLSGKWFEALSYGVDPVSHRIDMDEVERTARRERPRLIIAGGSAYARVPDFARFRAIADATGALFVADMAHYAGLVAGGAFPSPVPFAHVTTTTTHKTLRGPRGGMILTDDADIARRIDAAVFPGLQGGPLMHVIAAKAVALGEALQPGFRAYARAVIDNARALCARLAEGGLSIVSGGTDCHLGVVDLRPWGLAGNAAERALEEAGITVNKNAVPGDAASPAVTSGIRVGSAACTSRGMGPAEFRQIGDLVLAVLGGLRDGGQAGGRDAVPARAAELSRRFPLPY

Gene
glyA1
Protein
Serine hydroxymethyltransferase 1
Organism
Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)
Length
430 amino acids
Function
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
Similarity
Belongs to the SHMT family.
Mass
45.238 kDa
Sequence
MNDLLPAAAAPAGARALPLRHADPEIWRAVDAERQRQMHSIELIASENFVSQAVLDAQGSVMTNKYAEGYPGRRYYGGCRHVDVAERAAIERARRLFGCEYANVQPHSGSQANQAVYLALLAPGDRILGLDLKAGGHLTHGARVNLSGKWFEALSYGVDPVSHRIDMDEVERTARRERPRLIIAGGSAYARVPDFARFRAIADATGALFVADMAHYAGLVAGGAFPSPVPFAHVTTTTTHKTLRGPRGGMILTDDADIARRIDAAVFPGLQGGPLMHVIAAKAVALGEALQPGFRAYARAVIDNARALCARLAEGGLSIVSGGTDCHLGVVDLRPWGLAGNAAERALEEAGITVNKNAVPGDAASPAVTSGIRVGSAACTSRGMGPAEFRQIGDLVLAVLGGLRDGGQAGGRDAVPARAAELSRRFPLPY

Gene
glyA1
Protein
Serine hydroxymethyltransferase 1
Organism
Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50)
Length
430 amino acids
Function
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
Similarity
Belongs to the SHMT family.
Mass
45.219 kDa
Sequence
MNDLLPAAAAPAGARALPLRHADPEIWRAVDAERQRQMHSIELIASENFVSQAVLDAQGSVMTNKYAEGYPGRRYYGGCRHVDVAERAAIERARRLFGCEYANVQPHSGSQANQAVYLALLAPGDRILGLDLKAGGHLTHGAHVNLSGKWFEALSYGVDPVSHRIDMDEVERTARRERPRLIIAGGSAYARVPDFARFRAIADATGALFVADMAHYAGLVAGGAFPSPVPFAHVTTTTTHKTLRGPRGGMILTDDADIARRIDAAVFPGLQGGPLMHVIAAKAVALGEALQPGFRAYARAVIDNARALCARLAEGGLSIVSGGTDCHLGVVDLRPWGLAGNAAERALEEAGITVNKNAVPGDAASPAVTSGIRVGSAACTSRGMGPAEFRQIGDLVLAVLGGLRDGGQAGGRDAVPARAAELSRRFPLPY

Gene
glyA1
Protein
Serine hydroxymethyltransferase 1
Organism
Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)
Length
430 amino acids
Function
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
Similarity
Belongs to the SHMT family.
Mass
45.238 kDa
Sequence
MNDLLPAAAAPAGARALPLRHADPEIWRAVDAERQRQMHSIELIASENFVSQAVLDAQGSVMTNKYAEGYPGRRYYGGCRHVDVAERAAIERARRLFGCEYANVQPHSGSQANQAVYLALLAPGDRILGLDLKAGGHLTHGARVNLSGKWFEALSYGVDPVSHRIDMDEVERTARRERPRLIIAGGSAYARVPDFARFRAIADATGALFVADMAHYAGLVAGGAFPSPVPFAHVTTTTTHKTLRGPRGGMILTDDADIARRIDAAVFPGLQGGPLMHVIAAKAVALGEALQPGFRAYARAVIDNARALCARLAEGGLSIVSGGTDCHLGVVDLRPWGLAGNAAERALEEAGITVNKNAVPGDAASPAVTSGIRVGSAACTSRGMGPAEFRQIGDLVLAVLGGLRDGGQAGGRDAVPARAAELSRRFPLPY

Gene
glyA1
Protein
Serine hydroxymethyltransferase 1
Organism
Agrobacterium fabrum (strain C58 / ATCC 33970)
Length
429 amino acids
Function
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
Similarity
Belongs to the SHMT family.
Mass
46.562 kDa
Sequence
MSNTDAFFSRPLAEVDPDIFGAIEKELGRQRHEIELIASENIVSRAVLEAQGSIMTNKYAEGYPGKRYYGGCQFVDIAEELAIERAKKLFGVNFANVQPNSGSQMNQAVFLALLQPGDTFMGLDLNSGGHLTHGSPVNMSGKWFNVVSYGVREGDNLLDMDEVERKAKETRPKLILAGGTAYSRVWDWKRFREIADEVGAYLMVDMAHIAGLVAGGQHPSPFPHCHVATTTTHKSLRGPRGGMILTNDEDLAKKFNSAVFPGLQGGPLMHVIAAKAVAFGEALQPEFKDYAAQVVKNAKALAETLIEGGLDVVSGGTDNHLMLVDLRKKNATGKRAEAALGRAYITCNKNGIPFDPEKPFVTSGVRLGTPAGTTRGFKEAEFREIGKLIVEVLDGLKVANSDEGNASVEAAVREKVVGLTDRFPMYPYM

Gene
glyA1
Protein
Serine hydroxymethyltransferase 1
Organism
Agrobacterium fabrum (strain C58 / ATCC 33970)
Length
429 amino acids
Function
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
Similarity
Belongs to the SHMT family.
Mass
46.562 kDa
Sequence
MSNTDAFFSRPLAEVDPDIFGAIEKELGRQRHEIELIASENIVSRAVLEAQGSIMTNKYAEGYPGKRYYGGCQFVDIAEELAIERAKKLFGVNFANVQPNSGSQMNQAVFLALLQPGDTFMGLDLNSGGHLTHGSPVNMSGKWFNVVSYGVREGDNLLDMDEVERKAKETRPKLILAGGTAYSRVWDWKRFREIADEVGAYLMVDMAHIAGLVAGGQHPSPFPHCHVATTTTHKSLRGPRGGMILTNDEDLAKKFNSAVFPGLQGGPLMHVIAAKAVAFGEALQPEFKDYAAQVVKNAKALAETLIEGGLDVVSGGTDNHLMLVDLRKKNATGKRAEAALGRAYITCNKNGIPFDPEKPFVTSGVRLGTPAGTTRGFKEAEFREIGKLIVEVLDGLKVANSDEGNASVEAAVREKVVGLTDRFPMYPYM

Gene
glyA1
Protein
Serine hydroxymethyltransferase 1
Organism
Hahella chejuensis (strain KCTC 2396)
Length
426 amino acids
Function
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
Similarity
Belongs to the SHMT family.
Mass
46.213 kDa
Sequence
MFTEDMRIADYDPELSAAINAEKRRQEEHIELIASENYVSPRVMEAQGGVLTNKYAEGYPGKRYYGGCEHVDVAEQLAIDRAKQLFGADYANVQPHSGSQANAGVYLALAKPGDTILGMSLDHGGHLTHGAKPNFSGKIFNAVQYGLNPETGEIDYDQVERLAKEHKPKLVIAGFSAYSRVVDWQRFRDIADSVGAYLIVDMAHVAGLVAAGLYPSPVQIADVTTTTTHKTLRGPRGGLILAKSNPEIEKKLQSLIFPGIQGGPLMHVIAAKAVAFKEALEPAFRDYQQQVVNNARAMADAVKARGYKVVSGGTDNHLFLIDLIDKGVTGKDADAALGRAYITVNKNTVPNDPQSPFVTSGLRIGTPGVTTRGFKEKEVVELANWICDVLDNMGDESVVEKVREKVLSICRDFPVYRANAKSGAAL

Gene
glyA1
Protein
Serine hydroxymethyltransferase 1
Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Length
426 amino acids
Function
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
Similarity
Belongs to the SHMT family.
Mass
45.001 kDa
Sequence
MSAPLAEVDPDIAELLAKELGRQRDTLEMIASENFAPRAVLQAQGSVLTNKYAEGLPGRRYYGGCEHVDVVENLARDRAKALFGAEFANVQPHSGAQANAAVLHALMSPGERLLGLDLANGGHLTHGMRLNFSGKLYENGFYGVDPATHLIDMDAVRATALEFRPKVIIAGWSAYPRVLDFAAFRSIADEVGAKLLVDMAHFAGLVAAGLHPSPVPHADVVSTTVHKTLGGGRSGLIVGKQQYAKAINSAVFPGQQGGPLMHVIAGKAVALKIAATPEFADRQRRTLSGARIIADRLMAPDVAKAGVSVVSGGTDVHLVLVDLRDSPLDGQAAEDLLHEVGITVNRNAVPNDPRPPMVTSGLRIGTPALATRGFGDTEFTEVADIIATALATGSSVDVSALKDRATRLARAFPLYDGLEEWSLVGR

Gene
glyA1
Protein
Serine hydroxymethyltransferase 1
Organism
Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)
Length
424 amino acids
Function
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
Similarity
Belongs to the SHMT family.
Mass
45.454 kDa
Sequence
MSNTQPFFSQPLAERDAPVRSAILKELERQQSQVELIASENIVSRAVLEAQGSVLTNKYAEGYPGKRYYGGCEFADEVEALAIDRVKQIFNAGYANVQPHSGAQANGSVMLALAKPGDTVLGMSLDAGGHLTHGAKPALSGKWFNAVQYGVNRDTMLIDYDQVEALAHEHKPNLIIAGFSAYPRALDFARFRAIADSVGAKLMVDMAHIAGVIAAGRHANPVEHAHVVTSTTHKTLRGPRGGFVLTNDEDIAKKINSAVFPGLQGGPLMHVIAGKAVAFGEVLQADFKTYIDNVLANAQALGEVLKAGGVDLVTGGTDNHLLLVDLRPKGLKGAPVEQALERAGITCNKNGIPFDTEKPTVTSGIRLGTPAGTTRGFGVAEFREVGRLILEVFDALRANPEGDHATEQRVRREIFALCERFPIY

Gene
glyA1
Protein
Serine hydroxymethyltransferase 1
Organism
Colwellia psychrerythraea (strain 34H / ATCC BAA-681)
Length
419 amino acids
Function
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
Similarity
Belongs to the SHMT family.
Mass
45.555 kDa
Sequence
MFTRDMNIATFDPELFEAMSNEVVRQEEHIELIASENYCSPRVLEAQGSQLTNKYAEGYPGKRYYGGCEYVDIAEQLAIDRAKELFGATYANVQPHAGSQANAAVFQALVTPGGKVLGMSLAHGGHLTHGSHVSFSGKSYEAFQYGLHPETGDIDYEELERLAVEHKPEMIIGGFSAFSGVVDWARMRTIADKVGAYFFVDMAHVAGLIAAGLYPNPVPHAHVVTTTTHKTLAGPRGGLIISGCDDEAIYKKLNSAVFPGGQGGPLMHIIAAKAVAFKEALSPEFKVYQQNVLANALAMVDVLQDRGYKVVSNGTQNHLLLLDLIDKDITGKDADAALGKAHITVNKNSVPNDPRSPFVTSGLRLGTPAITRRGFGIEETKALTGWICDILDDIENEDVSKRVQDQVKELCARFPVYQK

Gene
glyA1
Protein
Serine hydroxymethyltransferase
Organism
Alteromonas mediterranea (strain DSM 17117 / CIP 110805 / LMG 28347 / Deep ecotype)
Length
418 amino acids
Function
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
Similarity
Belongs to the SHMT family.
Mass
45.095 kDa
Sequence
MFSREMNIADFDPELANAMANEVERQEHHIELIASENYCSPRVMEAQGSQLTNKYAEGYPGKRYYGGCEHVDVVEQLAIDRAKELFGADYANVQPHAGSQANSAVFMALLDAGDTVLGMSLSEGGHLTHGSHVNFSGKTYNAVQYGLDKETGEIDYAQVEALAKEHKPKMIIGGFSAYSGIVDWAKFREIADSVGAYLLVDMAHVAGLVAAGVYPNPLPHAHVVTTTTHKTLAGPRSGLILSSCGDEAIYKKLNSSVFPGNQGGPLCHVIAAKAVAFKEALQPEFKAYQQQVVANAKAMVSVMQERGYNIVSGGTDNHLFLLDLIDKDITGKDADAALGAANITVNKNSVPNDPRSPFVTSGLRIGSPAITRRGFKEEQAKQVATWICDILDNMGDESVIKRVQSEVVALCAQFPVYK

Gene
glyA1
Protein
Serine hydroxymethyltransferase 1
Organism
Salmonella typhi
Length
417 amino acids
Function
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
Similarity
Belongs to the SHMT family.
Mass
45.455 kDa
Sequence
MLKREMNIADYDAELWQAMEQEKVRQEEHIELIASENYTSPRVMQAQGSQLTNKYAEGYPGKRYYGGCEYVDVVEQLAIDRAKELFGADYANVQPHSGSQANFAVYTALLQPGDTVLGMNLAQGGHLTHGSPVNFSGKLYNIVPYGIDESGKIDYDEMAKLAKEHKPKMIIGGFSAYSGVVDWAKMREIADSIGAYLFVDMAHVAGLIAAGVYPNPVPHAHVVTTTTHKTLAGPRGGLILAKGGDEELYKKLNSAVFPSAQGGPLMHVIAGKAVALKEAMEPEFKVYQQQVAKNAKAMVEVFLNRGYKVVSGGTENHLFLLDLVDKNLTGKEADAALGRANITVNKNSVPNDPKSPFVTSGIRIGSPAVTRRGFKEAEVKELAGWMCDVLDNINDEATIERVKAKVLDICARFPVYA

Gene
glyA1
Protein
Serine hydroxymethyltransferase 1
Organism
Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672)
Length
417 amino acids
Function
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
Similarity
Belongs to the SHMT family.
Mass
45.312 kDa
Sequence
MLKREMNIADYDADLWQAMEQEVVRQEEHIELIASENYTSPRVMQAQGSQLTNKYAEGYPGKRYYGGCEYVDIVEQLAIDRAKALFGADYANVQPHSGSQANFAVYTALLQPGDTILGMNLAHGGHLTHGSPVNLSGKLYKVIPYGIDESGKIDYDEMAELARTHQPKMIVGGFSAYSGVVDWAKMREIADSIGAYLFVDMAHVAGLIAADVYPNPVPHAHIVTTTTHKTLAGPRGGLILAKGGDEDLYKKLNSAVFPGGQGGPLMHVIAGKAVALKEAMEPEFKVYQQQVAKNAKAMVEVFLSRGFNVVSGATSNHLFLLDLVSKNLTGKEADAALGRANITVNKNSVPNDPKSPFVTSGIRIGTPAATRRGFKEAEVRELAGWICDVLDNINDEATIERVKQKVLDICARFPVYA

Gene
glyA1
Protein
Serine hydroxymethyltransferase 1
Organism
Pseudomonas savastanoi pv. phaseolicola (strain 1448A / Race 6)
Length
417 amino acids
Function
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
Similarity
Belongs to the SHMT family.
Mass
44.844 kDa
Sequence
MFSRDLTIAKYDADLFAAMEQEALRQEEHIELIASENYTSPAVMEAQGSALTNKYAEGYPGKRYYGGCEYVDVIEQLAIDRAKELFGADYANVQPHAGSQANSAVYLALLQGGDTILGMSLAHGGHLTHGASVSSSGKLYNAVQYGIDANGMIDYDEVERLAVEHKPKMIVAGFSAYSQILDFPRFRAIADKVGAYLFVDMAHVAGLVAAGVYPNPVPFADVVTTTTHKTLRGPRGGLILARANAEIEKKLNSAVFPGSQGGPLEHVIAAKAVCFKEALQPEFKTYQQQVVKNAKAMAGVFIERGFDVVSGGTENHLFLLSLIKQDISGKDADAALGRAFITVNKNSVPNDPRSPFVTSGLRFGTPAVTTRGFKEAECKELAGWICDILADLNNEAVIDAVREKVKAICAKLPVYGA

Gene
glyA1
Protein
Serine hydroxymethyltransferase 1
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Length
417 amino acids
Function
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
Similarity
Belongs to the SHMT family.
Mass
44.7 kDa
Sequence
MFSKHDQIRGYDDELLAAMDAEEARQEDHLELIASENYTSKRVMQAQGSGLTNKYAEGYPGKRYYGGCEHVDKVERLAIDRARQLFGADYANVQPHSGSSANAAVYLALLNAGDTILGMSLAHGGHLTHGAKVSSSGKLYNAVQYGLDTATGLIDYDEVERLAVEHKPKMIVAGFSAYSKTLDFPRFRAIADKVGALLFVDMAHVAGLVAAGLYPNPIPFADVVTTTTHKTLRGPRGGLILARANEEIEKKLNSAVFPGAQGGPLMHVIAAKAVCFKEALEPGFKDYQAQVIRNAKAMAEVFIGRGYDVVSGGTDNHLMLISLVRQGLTGKEADAALGRVGITVNKNAVPNDPQSPFVTSGIRIGTPAITTRGLQEAQSRELAGWICDILDHLGDADVEAKVATQVAGLCADFPVYR

Gene
glyA1
Protein
Serine hydroxymethyltransferase 1
Organism
Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)
Length
417 amino acids
Function
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
Similarity
Belongs to the SHMT family.
Mass
44.892 kDa
Sequence
MFSRDLTIAKYDADLFAAMEQEAQRQEEHIELIASENYTSPAVMEAQGSVLTNKYAEGYPGKRYYGGCEYVDVVEQLAIDRAKELFGADYANVQPHAGSQANAAVYLALLQGGDTILGMSLAHGGHLTHGAAVSSSGKLYNAIQYGIDANGLIDYDEVERLAVEHKPKMIVAGFSAYSQILDFPRFREIADKVGAYLFVDMAHVAGLVAAGVYPNPVPFADVVTTTTHKTLRGPRGGLILARANADIEKKLNSAVFPGAQGGPLEHVIAAKAICFKEALQPEFKAYQEQVVKNAQAMAEVFIARGFDVVSGGTKNHLFLLSLIKQDISGKDADAALGKAFITVNKNSVPNDPRSPFVTSGLRFGTPAVTTRGFKEAECKELAGWICDILADLNNEAVIDAVREKVKAICKKLPVYGA

Gene
glyA1
Protein
Serine hydroxymethyltransferase 1
Organism
Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)
Length
417 amino acids
Function
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
Similarity
Belongs to the SHMT family.
Mass
44.556 kDa
Sequence
MFSKQDQIQGYDDALLAAMNAEEQRQEDHIELIASENYTSKRVMQAQGSGLTNKYAEGYPGKRYYGGCEHVDKVEALAIERAKQLFGADYANVQPHSGSSANGAVYLALLQAGDTILGMSLAHGGHLTHGAKVSSSGKLYNAVQYGIDTNTGLIDYDEVERLAVEHKPKMIVAGFSAYSKTLDFPRFRAIADKVGALLFVDMAHVAGLVAAGLYPNPIPFADVVTTTTHKTLRGPRGGLILAKSNEEIEKKLNAAVFPGAQGGPLMHVIAAKAVCFKEALEPGFKAYQQQVIENAQAMAQVFIDRGYDVVSGGTDNHLFLVSLIRQGLTGKDADAALGRAHITVNKNAVPNDPQSPFVTSGLRIGTPAVTTRGFKVAQCVALAGWICDILDNLGDADVEADVAKNVAALCADFPVYR

Gene
glyA1
Protein
Serine hydroxymethyltransferase 1
Organism
Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)
Length
417 amino acids
Function
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
Similarity
Belongs to the SHMT family.
Mass
44.875 kDa
Sequence
MFSKQDQIQGYDDALLSAMNAEEQRQEDHIELIASENYTSKRVMQAQGSGLTNKYAEGYPGKRYYGGCEHVDKVEQLAIERARQLFGADYANVQPHSGSQANAAVYLALLQAGDTVLGMSLAHGGHLTHGAKVSFSGKLYNAVQYGIDTTTGLIDYDEVERIAVECQPKMLIAGFSAYSKTLDFPRFRAIADKVGAYLFVDMAHVAGLVAAGLYPNPLPYADVVTTTTHKTLRGPRGGLILAKANEELEKKFNSAVFPGGQGGPLMHVIAAKAVCFKEAMEPGFKTYQQQVIDNAQAMAQVFITRGFDVVSGGTDNHLFLVSLIRQGLTGKEADAALGRAHITVNKNSVPNDPQSPFVTSGLRIGTPAVTTRGFKVTQCIELAGWICDILDNLGAADVEANVASQVAALCADFPVYR

Gene
glyA1
Protein
Serine hydroxymethyltransferase 1
Organism
Pseudomonas syringae pv. syringae (strain B728a)
Length
417 amino acids
Function
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
Similarity
Belongs to the SHMT family.
Mass
44.858 kDa
Sequence
MFSRDLTIAKYDADLFAAMEQEALRQEEHIELIASENYTSPAVMEAQGSALTNKYAEGYPGKRYYGGCEYVDIIEQLAIDRAKELFGADYANVQPHAGSQANSAVYLALLQGGDTILGMSLAHGGHLTHGASVSSSGKLYNAVQYGIDANGMIDYDEVERLAVEHKPKMIVAGFSAYSQILDFPRFRAIADKVGAYLFVDMAHVAGLVAAGVYPNPVPFADVVTTTTHKTLRGPRGGLILARANAEIEKKLNSAVFPGSQGGPLEHVIAAKAVCFKEALQPEFKTYQQQVVKNAKAMAGVFIERGFDVVSGGTENHLFLLSLIKQDISGKDADAALGRAFITVNKNSVPNDPRSPFVTSGLRFGTPAVTTRGFKEAECKELAGWICDILADLNNEAVIDAVREKVKAICAKLPVYGA

Gene
glyA1
Protein
Serine hydroxymethyltransferase 1
Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Length
416 amino acids
Function
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
Similarity
Belongs to the SHMT family.
Mass
45.409 kDa
Sequence
MLKRDMNIADYDPELYAAIQEETLRQEEHIELIASENYTSPRVMQAQGSQLTNKYAEGYPGKRYYGGCEYVDKAEALAIDRACQLFGCEYANVQPHSGSQANSAVYMALLNPGDTVLGMSLAHGGHLTHGSPVNFSGKHYNVIPYGIDEAGQINYDEMEALALEHKPKMIIGGFSAYSQIVDWKRMREIADKVGAYLFVDMAHVAGLIAAGVYPSPVPFAHVVTTTTHKTLAGPRGGLILSNAGEEMYKKLNSAVFPGGQGGPLMHVIAAKAVAFKEAMEPEFKEYQARVVKNAKAMVAQFQERGYKIVSNSTENHLFLVDLIDKNITGKEADAALGAANITVNKNSVPNDPRSPFVTSGIRVGTPAITRRGFTEQDAKDLANWMCDVLDNINDQGVIEATKQKVLAICQRLPVYA

Gene
glyA1
Protein
Serine hydroxymethyltransferase 1
Organism
Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Length
416 amino acids
Function
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
Similarity
Belongs to the SHMT family.
Mass
45.505 kDa
Sequence
MLKRDMNIADYDAELFAAIQEETLRQEEHIELIASENYTSPRVMEAQGSQLTNKYAEGYPGKRYYGGCEYVDKAEQLAIDRACKLFGCEYANVQPHSGSQANSAVYMALLNPGDTVLGMSLAHGGHLTHGSPVNFSGKHYNVIPYGIDEAGQINYDEMEQLALEHKPKMIIGGFSAYSQIVDWKRMREIADKVDAYLFVDMAHVAGLIAAGEYPTPVPHAHVVTTTTHKTLAGPRGGLILSNAGEDMYKKLNSAVFPGGQGGPLMHVIAGKAVAFKEAMEPEFKAYQARVVKNAKAMVGQFQERGYKIVSNGTENHLFLVDLIDKDITGKDADAALGAANITVNKNSVPNDPRSPFVTSGIRVGTPAITRRGFTEEDAKDLANWMCDVLDNIGNEEVIEATKQKVLEICKRLPVYA

Gene
glyA1
Protein
Serine hydroxymethyltransferase 1
Organism
Vibrio vulnificus (strain CMCP6)
Length
416 amino acids
Function
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
Similarity
Belongs to the SHMT family.
Mass
45.332 kDa
Sequence
MLKRDMNIADYDAELFAAIQEETLRQEEHIELIASENYTSPRVMEAQGSQLTNKYAEGYPGKRYYGGCEYVDKAEALAIDRACQLFGCEYANVQPHSGSQANSAVYMALLNPGDTVLGMSLAHGGHLTHGSPVNFSGKHYNVIPYGIDEAGQINYDEMETLALEHKPKMIIGGFSAYSQIVDWKRMREIADKVDAYLFVDMAHVAGLIAAGEYPTPVPHAHVVTTTTHKTLAGPRGGLILSNAGEDMYKKLNSAVFPGGQGGPLMHVIAGKAVAFKEAMEPEFKAYQARVVKNAKAMVAQFQERGYKIVSNGTENHLFLVDLIDKDITGKDADAALGAANITVNKNSVPNDPRSPFVTSGIRVGTPAITRRGFTEADAKELANWMCDVLDNIGNEAVIEATKQKVLEICKRLPVYA

Gene
glyA1
Protein
Serine hydroxymethyltransferase 1
Organism
Vibrio vulnificus (strain YJ016)
Length
416 amino acids
Function
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
Similarity
Belongs to the SHMT family.
Mass
45.332 kDa
Sequence
MLKRDMNIADYDAELFAAIQEETLRQEEHIELIASENYTSPRVMEAQGSQLTNKYAEGYPGKRYYGGCEYVDKAEALAIDRACQLFGCEYANVQPHSGSQANSAVYMALLNPGDTVLGMSLAHGGHLTHGSPVNFSGKHYNVIPYGIDEAGQINYDEMETLALEHKPKMIIGGFSAYSQIVDWKRMREIADKVDAYLFVDMAHVAGLIAAGEYPTPVPHAHVVTTTTHKTLAGPRGGLILSNAGEDMYKKLNSAVFPGGQGGPLMHVIAGKAVAFKEAMEPEFKAYQARVVKNAKAMVAQFQERGYKIVSNGTENHLFLVDLIDKDITGKDADAALGAANITVNKNSVPNDPRSPFVTSGIRVGTPAITRRGFTEADAKELANWMCDVLDNIGNEAVIEATKQKVLEICKRLPVYA

Gene
glyA1
Protein
Serine hydroxymethyltransferase 1
Organism
Photobacterium profundum (strain SS9)
Length
416 amino acids
Function
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
Similarity
Belongs to the SHMT family.
Mass
45.19 kDa
Sequence
MLKRDMNIADYDAELFAAIQEETARQEEHIELIASENYTSPRVMEAQGSQLTNKYAEGYPGKRYYGGCEFVDKAEQLAIDRACQLFGAEYANVQPHSGSQANNAVYMALLNPGDTVLGMSLAHGGHLTHGSPVNFSGKLYNIIPYGIDETGQIDYEEMEALALEHKPKMIIGGFSAYSQVVDWKRMREIADKVGAYFFVDMAHVAGLIAAGVYPNPVPHAHVVTTTTHKTLAGPRGGLILSNDGEALYKKLNSAVFPGGQGGPLMHVIAAKAVAFKEAMEPEFKVYQACVVENAKAMVGEFLERGYKIVSGSTENHLFLVDLIDKGITGKEADAALGAANITVNKNSVPNDPRSPFVTSGIRIGTPSITRRGFTVEDTKQLAGWICDVLDNTDKPEVIEATKAKVLEICKRLPVYA

Gene
glyA1
Protein
Serine hydroxymethyltransferase 1
Organism
Ralstonia solanacearum (strain GMI1000)
Length
415 amino acids
Function
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
Similarity
Belongs to the SHMT family.
Mass
44.973 kDa
Sequence
MFERNRYTIDQIDPEVFAAIQQENQRQEDHIELIASENYTSPAVMAAQGSQLTNKYAEGYPGKRYYGGCEYVDVVEQLAIDRVKQLFGAEAANVQPNSGSQANQGVFFAMLKPGDTIMGMSLAEGGHLTHGMALNMSGKWFNVVSYGLNAQEDIDYDALEALAQEKKPKLIIAGASAFALRIDFERIAKVAKAVGAYFMVDMAHYAGLIAAGVYPNPVPHADFVTTTTHKSLRGPRGGVILMKAEHEKAINSAIFPGIQGGPLMHVIAGKAVAFKEAQSPTFKAYQEQVVKNARAMAETLMARGLRIVSGRTESHVMLVDLRAKSITGKEAEKVLGDAHITVNKNAIPNDPEKPFVTSGIRLGSPAMTTRGFKEGEAVKVAHLIADVLDNPHDEANIAAVRAKVAELTKQFPVYA

Gene
glyA1
Protein
Serine hydroxymethyltransferase 1
Organism
Sulfurimonas denitrificans (strain ATCC 33889 / DSM 1251)
Length
415 amino acids
Function
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
Similarity
Belongs to the SHMT family.
Mass
45.183 kDa
Sequence
MSFLKEFDKDIFDLCEKELERQSNHLEMIASENFTLPAVMEAMGSVFTNKYAEGYPAKRYYGGCEYADGVEQLAIDRACKLFGCNYANVQPHSGSQANAAVYAALLKAGDKLLGMDLSHGGHLTHGSKPSFSGQNYSSFTYGVELDGRMNYDKILEIAKAVQPKIIVCGASAYAREIDFKKFREIADAVGAIMFADIAHVAGLVVAGEHMSPFPHAHVVTTTTHKTLAGPRGGMIMTNDEDIAKKINSAIFPGIQGGPLVHVIAAKAVGFKYNLSAEWKDYAVQVKANAKILGEVLVKRGYDLVSGGTDNHLVLLSFLNRDFSGKDADIALGNAGITVNKNTVPGETRSPFVTSGIRIGSPALTSRGMKEREFEFIANKIADVLDDINNTKLQESVKKELKELAQKFVIYNQSTY

Gene
glyA1
Protein
Serine hydroxymethyltransferase 1
Organism
Burkholderia mallei (strain ATCC 23344)
Length
415 amino acids
Function
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
Similarity
Belongs to the SHMT family.
Mass
44.985 kDa
Sequence
MFDRAQSTIANVDPEIWQAIQQENVRQEEHIELIASENYTSPAVMAAQGSQLTNKYAEGYPGKRYYGGCEYVDIVEQLAIDRVKALFGAEAANVQPNSGSQANQGVFFAMLKPGDTIMGMSLAHGGHLTHGSPVNMSGKWFNVVSYGLNEAEDIDYEAAEQLAHEHKPKLIVAGASAFALKIDFERLAKIAKAVGAYLMVDMAHYAGLIAAGVYPNPVPHADFVTTTTHKSLRGPRGGVILMKAEYEKQINSAIFPGIQGGPLMHVIAAKAVAFKEALSPEFKEYQQKVVENARVLAQTLVKRGLRIVSGRTESHVMLVDLRAKNITGKAAEAALGNAHITVNKNAIPNDPEKPFVTSGVRLGSPAMTTRGFGPQEAELVGNLIADVLEHPEDAATIERVRAQVAELTKRFPVYR

Gene
glyA1
Protein
Serine hydroxymethyltransferase 1
Organism
Burkholderia pseudomallei (strain 1710b)
Length
415 amino acids
Function
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
Similarity
Belongs to the SHMT family.
Mass
44.985 kDa
Sequence
MFDRAQSTIANVDPEIWQAIQQENVRQEEHIELIASENYTSPAVMAAQGSQLTNKYAEGYPGKRYYGGCEYVDIVEQLAIDRVKALFGAEAANVQPNSGSQANQGVFFAMLKPGDTIMGMSLAHGGHLTHGSPVNMSGKWFNVVSYGLNEAEDIDYEAAEQLAHEHKPKLIVAGASAFALKIDFERLAKIAKAVGAYLMVDMAHYAGLIAAGVYPNPVPHADFVTTTTHKSLRGPRGGVILMKAEYEKQINSAIFPGIQGGPLMHVIAAKAVAFKEALSPEFKEYQQKVVENARVLAQTLVKRGLRIVSGRTESHVMLVDLRAKNITGKAAEAALGNAHITVNKNAIPNDPEKPFVTSGVRLGSPAMTTRGFGPQEAELVGNLIADVLEHPEDAATIERVRAQVAELTKRFPVYR

Gene
glyA1
Protein
Serine hydroxymethyltransferase 1
Organism
Burkholderia pseudomallei (strain K96243)
Length
415 amino acids
Function
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
Similarity
Belongs to the SHMT family.
Mass
44.985 kDa
Sequence
MFDRAQSTIANVDPEIWQAIQQENVRQEEHIELIASENYTSPAVMAAQGSQLTNKYAEGYPGKRYYGGCEYVDIVEQLAIDRVKALFGAEAANVQPNSGSQANQGVFFAMLKPGDTIMGMSLAHGGHLTHGSPVNMSGKWFNVVSYGLNEAEDIDYEAAEQLAHEHKPKLIVAGASAFALKIDFERLAKIAKAVGAYLMVDMAHYAGLIAAGVYPNPVPHADFVTTTTHKSLRGPRGGVILMKAEYEKQINSAIFPGIQGGPLMHVIAAKAVAFKEALSPEFKEYQQKVVENARVLAQTLVKRGLRIVSGRTESHVMLVDLRAKNITGKAAEAALGNAHITVNKNAIPNDPEKPFVTSGVRLGSPAMTTRGFGPQEAELVGNLIADVLEHPEDAATIERVRAQVAELTKRFPVYR

Gene
glyA1
Protein
Serine hydroxymethyltransferase 1
Organism
Burkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CIP 106301 / E264)
Length
415 amino acids
Function
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
Similarity
Belongs to the SHMT family.
Mass
45.031 kDa
Sequence
MFDRAQSTIANVDPEIWQAIQQENVRQEEHIELIASENYTSPAVMAAQGSQLTNKYAEGYPGKRYYGGCEYVDIVEQLAIDRVKALFGSEAANVQPNSGSQANQGVFFAMLKPGDTIMGMSLAHGGHLTHGSPVNMSGKWFNVVSYGLNENEDIDYEAADKLAHEHKPKLIVAGASAFALKIDFERLAKIAKAVGAYLMVDMAHYAGLIAAGVYPNPVPHADFVTTTTHKSLRGPRGGVILMKAEYEKQINSAIFPGIQGGPLMHVIAAKAVAFKEALSPEFKEYQQKVIENARVLAETLVKRGLRIVSGRTESHVMLVDLRAKNITGKAAEAALGNAHITVNKNAIPNDPEKPFVTSGVRLGSPAMTTRGFGPQEAELVGNLIADVLEHPEDAATIERVRAQVADLTKRFPVYR

Gene
glyA1
Protein
Serine hydroxymethyltransferase 1
Organism
Cupriavidus necator (strain JMP 134 / LMG 1197)
Length
415 amino acids
Function
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
Similarity
Belongs to the SHMT family.
Mass
45.087 kDa
Sequence
MFERSRYTIDQIDPEVFAAIQKENQRQEDHIELIASENYTSPAVMAAQGSQLTNKYAEGYPGKRYYGGCEYVDIVEQLAIDRVKQLFGAEAANVQPNSGSQANQGVYFAVLKPGDTIMGMSLAEGGHLTHGMALNMSGKWFNVVSYGLNAQEDIDYDALEKLAQEKKPKLIIAGASAFALRIDFERIGKVAKSIGAYFMVDMAHYAGLIAAGVYPNPVPHADFVTTTTHKSLRGPRGGVILMKAEHEKAINSSIFPGIQGGPLMHVIAGKAVAFKEALTPEFKAYQEQVVKNAAVLAETLIARGLRIVSGRTESHVMLVDLRAKNITGKEAERILGEAHLTVNKNAIPNDPEKPFVTSGIRVGSPAMTTRGFKEEEARIVGNLIADVLDNPHDAGNIASVREQVSALTKRFPVYG

Gene
glyA1
Protein
Serine hydroxymethyltransferase 1
Organism
Pseudomonas fluorescens (strain Pf0-1)
Length
412 amino acids
Function
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
Similarity
Belongs to the SHMT family.
Mass
45.462 kDa
Sequence
MSLQNFDPAIARLIDRERNRQETHLELIASENYVSEEVLQAQGSLLTNKYAEGYPGRRYYGGCKVVDEIENLAIERARKLFGCEYVNVQPHSGSQANQAVFLAVLEPGDRILGMSLAHGGHLTHGASVNFSGKFFQAFTYGLEKDSETLDYDQMEDLAREHRPKMIIAGASAYSRVIDFPRFRKICDEIGAYLMVDMAHYAGLIAAGVYPSPVGIADFITSTTHKTLRGPRGGLILAKAEYAAVLDKTIFPVYQGGPLMHVIAAKAVAFNEALGDEFKHYQQRVINNARTMADVLTRRGLRVVSGGTDCHMFLLDLRAMNITGKDAEALLESAHITLNKNAIPDDPQKPAITSGIRIGTPALTTRGFGEAECAEVANLIADLLEQPDNTARVENIRRRVMHLCECFPVYLLT