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glpF4

Gene
glpF4
Protein
Glycerol uptake facilitator protein 4
Organism
Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Length
238 amino acids
Function
Transporter that facilitates the transmembrane diffusion of water, dihydroxyacetone, glycerol, urea, H(2)O(2) and D/L-lactic acid. Is involved in the cellular racemization of lactate and lactate metabolism, but has likely a more general physiological role. The transported molecule is indeed lactic acid and not the lactate anion, in agreement with the assumption that, with very few exceptions, MIPs (major intrinsic proteins) only facilitate the transport of uncharged solutes.
Similarity
Belongs to the MIP/aquaporin (TC 1.A.8) family.
Mass
25.367 kDa
Sequence
MIHQLLAEFMGTALMIIFGVGVHCSEVLKGTKYRGSGHIFAITTWGFGITIALFIFGNVCINPAMVLAQCILGNLSWSLFIPYSVAEVLGGVVGAVIVWIMYADHFAASADEISPITIRNLFSTAPAVRNLPRNFFVEFFDTFIFISGILAISEVKTPGIVPIGVGLLVWAIGMGLGGPTGFAMNLARDMGPRIAHAILPIKNKADSDWQYGIIVPGIAPFVGAACAALFMHGFFGIG