glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

1076 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

120.299 kDa

MESSIFKPSSMDLIRAGLQDLDKARALFDQLKADDIPDERCAELLSALAHACDPDMALSNFVDIVNAMQSSQRDLEHVIPDNDALKRLVTVLGVSDAMGKFMRFKPQLVEAAAVDNCNSHLFNHAQRRARLLKAVGADPDEPAMPVASKDLAEAATALRSSYRNQLAAIIAQDAVADDPTSIQPTISRELSDLADAALEGALAIARHETEGSEHVRFTIIGMGKLGAQELNYVSDVDLIYVVEPADKDVDHQTLIRVGTKMGTMLQRVCQSAIMGVAEQPLWQIDGGLRPEGKDGALVRVLSSHKNYYEQWAENWEFQALLKARPVAGDPDLGQAYMDMTRPFVWSASKRKNFVYDCQKMRKRVEDLIPAPLKDREIKLGRGGLRDVEFTVQMLQLVHGRTDESLRTSNTLDSLQRLSEGGYVSRKQAVRMSQDYRFERVMEHRQQIWSLKRTHLFPDLGRASVGGLEKKRDIDVDELNQNQELRRLARAFGLHPEELVDKYDDTRREVRHLHLDIYYRPMLPVNAQMENDQIVLSVEAAQERFESIGFGDPDAAIRHVQALTAGVGRAAKINRIILPAVLQWLGEGQNPDMGLLNWRKLEENFGTESGYLGFLRDSTSAAQRLCHILSNSRFLGDALNKSVESISWLGDDDNLQARTREALDVQTGSALERFGSNINEFATSMRAMRRHEIERIGLSWMSGVISDSDSLKAMTDVYDAIIDASLTWAVRHQIAEFGVETAPAGITVIAMGRYGGREVNFSSDADAILIYRPADDADDGQANAFAKKVVEDLRNILQGPTTLEPKIELDLDLRPEGKNGPLVRSYASCEEYYESWASTWERQALLRARYAAGDAELARDFLINIADPLRYPTTELTEAELQNIRKLKARMEAERLPRGVRRERHLKLGKGGLSDVEWTVQLMQLQHAGDIKDLRVNGTLEALDVLEAKKLISAIDAIQLRKAWTLCTAARNGSYLWSGRANQADILPDDIYSLGGIAVYLGYGAHRGQHFENDLLAVMRKCRDVCQRLFYGKTEGEAAAATTATASAATQQPQTAPRPRMHVIAPRLERNRRRAQR

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

1076 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

120.297 kDa

MESSIFKPSSMDLIRAGLQDLDKARALFDQLKADDIPDERCAELLSALAHACDPDMALSNFVDIVNAMQSSQRDLEHVIPDNDALKRLVTVLGVSDAMGKFMRFKPQLVEAAAVDNCNSHLFNHAQRRARLLKAVGADPDEPAMPVASKDLAEAATALRSSYRNQLAAIIAQDAVADDPASIQPTISRELSDLADAALEGALAIARHETEGSEHVRFTIIGMGKLGAQELNYVSDVDLIYVVEPADKDVDHQTLIRVGTKMGTMLQRVCQSAIMGVAEQPLWQIDGGLRPEGKDGALVRVLSSHKNYYEQWAENWEFQALLKARPVAGDPDLGRAYMDMTRPFVWSASKRKNFVYDCQKMRKRVEDLIPAPLKDREIKLGRGGLRDVEFTVQMLQLVHGRTDESLRTSNTLDSLQRLSEGGYVSRKQAVRMSQDYRFERVMEHRQQIWSLKRTHLFPDLGRASVGGLEKKRDIDVDELNQNQELRRLARAFGLHPEELVDKYDDTRREVRHLHLDIYYRPMLPVNAQMENDQIVLSVEAAQERFESIGFGDPDAAIRHVQALTAGVGRAAKINRIILPAVLQWLGEGQNPDMGLLNWRKLEENFGTESGYLGFLRDSTSAAQRLCHILSNSRFLGDALNKSVESISWLGDDDNLQARTREALDVQTGSALERFGSNINEFATSMRAMRRHEIERIGLSWMSGVISDSDSLKAMTDVYDAIIDASLTWAVRHQIAEFGVETAPAGITVIAMGRYGGREVNFSSDADAILIYRPADDADDGQANAFAKKVVEDLRNILQGPTTLEPKIELDLDLRPEGKNGPLVRSYASCEEYYESWASTWERQALLRARYAAGDAELARDFLINIADPLRYPTTELTEAELQNIRKLKARMEAERLPRGVRRERHLKLGKGGLSDVEWTVQLMQLQHAGDIKDLRVNGTLEALDVLEAKKLISAIDAIQLRKAWTLCTAARNGSYLWSGRANQADILPDDIYSLGGIAVYLGYGAHRGQHFENDLLAVMRKCRDVCQRLFYGKTEGEAAAATTATASAATQQPQTAPRPRMHVIAPRLERNRRRAQR

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

1076 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

119.998 kDa

MESSMFKPSSMDLIRAGLQDLDRARALFGQLKADAIADGRCAELLGVLAHACDPDVALGNFVDIVNAMQSSRRDLDRVIPDAGALRRLITVLGASDAMGKFMRFRPELVEAASVGSADSHLFNRAQRRARLLMAVGADPDDQAMPVASKDLAEAATALRAGYRRQLAAIIAQDVMAEDPIRIQPTISSELSDLADAALEGALAIARHETEGNEHVRFTIIGMGKLGAQELNYVSDVDLIYVVEPADKDVDHQTLIRVGTKMGTMLQRVCQSVIMGVAEQPLWQIDGGLRPEGKDGALVRVLSSHKNYYEQWAENWEFQALLKARPVAGDPDLGQAYMDMSRPFVWSASKRKNFVYDCQKMRKRVEDLIPAPLKDREIKLGRGGLRDVEFTVQMLQLVHGRTDESLRTSNTLDSLQRLSEGGYVSRKQAVRMSQDYRFERVMEHRQQIWSLKRTHLFPDLGRASVGGLEKKRDIDVDELNQNQELRRLARAFGLHPEELVDKYDDTRREVRHLHLDIYYRPMLPVNAQMENDQIVLSVEAAQERFESIGFGDPDAAIRHVQALTAGVGRAAKINRIILPAVLQWLGEGQNPDMGLLNWRKLEENFGTESGYLGFLRDSTSAAQRLCHILSNSRFLGDALNKSVESISWLGDDGNLQARTREALDVQTGSALERFGSNINEFATSMRAMRRHEIERIGLSWMSGVISDSDSLKAMTDVYDAIIDASLTWAVRHQIAAFGVETAPAGITVIAMGRYGGREVNFSSDADAILIYRPADDADDGQANAFAKKVVEDLRNILQGPTTLEPKIELDLDLRPEGKNGPLVRSYASCEEYYESWASTWERQALLRARYAAGDAELARDFLINIADPLRYPTAELTEAELQNIRKLKARMEAERLPRGVRRERHLKLGKGGLSDVEWTVQLMQLQHAGDIKDLRVNGTLEALDVLEAKKLISAIDAIQLRKTWTLCTAARNGNYLWSGRANQADILPDDIYSLGGIAVYLGYGAHRGQHFENDLLAVMRKCRDVCQRLFYGQTEGEATAAATATASAATPQPQTAPRPRMHVIAPRLERNRRRAQR

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

1076 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

120.299 kDa

MESSIFKPSSMDLIRAGLQDLDKARALFDQLKADDIPDERCAELLSALAHACDPDMALSNFVDIVNAMQSSQRDLEHVIPDNDALKRLVTVLGVSDAMGKFMRFKPQLVEAAAVDNCNSHLFNHAQRRARLLKAVGADPDEPAMPVASKDLAEAATALRSSYRNQLAAIIAQDAVADDPTSIQPTISRELSDLADAALEGALAIARHETEGSEHVRFTIIGMGKLGAQELNYVSDVDLIYVVEPADKDVDHQTLIRVGTKMGTMLQRVCQSAIMGVAEQPLWQIDGGLRPEGKDGALVRVLSSHKNYYEQWAENWEFQALLKARPVAGDPDLGQAYMDMTRPFVWSASKRKNFVYDCQKMRKRVEDLIPAPLKDREIKLGRGGLRDVEFTVQMLQLVHGRTDESLRTSNTLDSLQRLSEGGYVSRKQAVRMSQDYRFERVMEHRQQIWSLKRTHLFPDLGRASVGGLEKKRDIDVDELNQNQELRRLARAFGLHPEELVDKYDDTRREVRHLHLDIYYRPMLPVNAQMENDQIVLSVEAAQERFESIGFGDPDAAIRHVQALTAGVGRAAKINRIILPAVLQWLGEGQNPDMGLLNWRKLEENFGTESGYLGFLRDSTSAAQRLCHILSNSRFLGDALNKSVESISWLGDDDNLQARTREALDVQTGSALERFGSNINEFATSMRAMRRHEIERIGLSWMSGVISDSDSLKAMTDVYDAIIDASLTWAVRHQIAEFGVETAPAGITVIAMGRYGGREVNFSSDADAILIYRPADDADDGQANAFAKKVVEDLRNILQGPTTLEPKIELDLDLRPEGKNGPLVRSYASCEEYYESWASTWERQALLRARYAAGDAELARDFLINIADPLRYPTTELTEAELQNIRKLKARMEAERLPRGVRRERHLKLGKGGLSDVEWTVQLMQLQHAGDIKDLRVNGTLEALDVLEAKKLISAIDAIQLRKAWTLCTAARNGSYLWSGRANQADILPDDIYSLGGIAVYLGYGAHRGQHFENDLLAVMRKCRDVCQRLFYGKTEGEAAAATTATASAATQQPQTAPRPRMHVIAPRLERNRRRAQR

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

1076 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

120.297 kDa

MESSIFKPSSMDLIRAGLQDLDKARALFDQLKADDIPDERCAELLSALAHACDPDMALSNFVDIVNAMQSSQRDLEHVIPDNDALKRLVTVLGVSDAMGKFMRFKPQLVEAAAVDNCNSHLFNHAQRRARLLKAVGADPDEPAMPVASKDLAEAATALRSSYRNQLAAIIAQDAVADDPASIQPTISRELSDLADAALEGALAIARHETEGSEHVRFTIIGMGKLGAQELNYVSDVDLIYVVEPADKDVDHQTLIRVGTKMGTMLQRVCQSAIMGVAEQPLWQIDGGLRPEGKDGALVRVLSSHKNYYEQWAENWEFQALLKARPVAGDPDLGRAYMDMTRPFVWSASKRKNFVYDCQKMRKRVEDLIPAPLKDREIKLGRGGLRDVEFTVQMLQLVHGRTDESLRTSNTLDSLQRLSEGGYVSRKQAVRMSQDYRFERVMEHRQQIWSLKRTHLFPDLGRASVGGLEKKRDIDVDELNQNQELRRLARAFGLHPEELVDKYDDTRREVRHLHLDIYYRPMLPVNAQMENDQIVLSVEAAQERFESIGFGDPDAAIRHVQALTAGVGRAAKINRIILPAVLQWLGEGQNPDMGLLNWRKLEENFGTESGYLGFLRDSTSAAQRLCHILSNSRFLGDALNKSVESISWLGDDDNLQARTREALDVQTGSALERFGSNINEFATSMRAMRRHEIERIGLSWMSGVISDSDSLKAMTDVYDAIIDASLTWAVRHQIAEFGVETAPAGITVIAMGRYGGREVNFSSDADAILIYRPADDADDGQANAFAKKVVEDLRNILQGPTTLEPKIELDLDLRPEGKNGPLVRSYASCEEYYESWASTWERQALLRARYAAGDAELARDFLINIADPLRYPTTELTEAELQNIRKLKARMEAERLPRGVRRERHLKLGKGGLSDVEWTVQLMQLQHAGDIKDLRVNGTLEALDVLEAKKLISAIDAIQLRKAWTLCTAARNGSYLWSGRANQADILPDDIYSLGGIAVYLGYGAHRGQHFENDLLAVMRKCRDVCQRLFYGKTEGEAAAATTATASAATQQPQTAPRPRMHVIAPRLERNRRRAQR

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

1076 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

119.998 kDa

MESSMFKPSSMDLIRAGLQDLDRARALFGQLKADAIADGRCAELLGVLAHACDPDVALGNFVDIVNAMQSSRRDLDRVIPDAGALRRLITVLGASDAMGKFMRFRPELVEAASVGSADSHLFNRAQRRARLLMAVGADPDDQAMPVASKDLAEAATALRAGYRRQLAAIIAQDVMAEDPIRIQPTISSELSDLADAALEGALAIARHETEGNEHVRFTIIGMGKLGAQELNYVSDVDLIYVVEPADKDVDHQTLIRVGTKMGTMLQRVCQSVIMGVAEQPLWQIDGGLRPEGKDGALVRVLSSHKNYYEQWAENWEFQALLKARPVAGDPDLGQAYMDMSRPFVWSASKRKNFVYDCQKMRKRVEDLIPAPLKDREIKLGRGGLRDVEFTVQMLQLVHGRTDESLRTSNTLDSLQRLSEGGYVSRKQAVRMSQDYRFERVMEHRQQIWSLKRTHLFPDLGRASVGGLEKKRDIDVDELNQNQELRRLARAFGLHPEELVDKYDDTRREVRHLHLDIYYRPMLPVNAQMENDQIVLSVEAAQERFESIGFGDPDAAIRHVQALTAGVGRAAKINRIILPAVLQWLGEGQNPDMGLLNWRKLEENFGTESGYLGFLRDSTSAAQRLCHILSNSRFLGDALNKSVESISWLGDDGNLQARTREALDVQTGSALERFGSNINEFATSMRAMRRHEIERIGLSWMSGVISDSDSLKAMTDVYDAIIDASLTWAVRHQIAAFGVETAPAGITVIAMGRYGGREVNFSSDADAILIYRPADDADDGQANAFAKKVVEDLRNILQGPTTLEPKIELDLDLRPEGKNGPLVRSYASCEEYYESWASTWERQALLRARYAAGDAELARDFLINIADPLRYPTAELTEAELQNIRKLKARMEAERLPRGVRRERHLKLGKGGLSDVEWTVQLMQLQHAGDIKDLRVNGTLEALDVLEAKKLISAIDAIQLRKTWTLCTAARNGNYLWSGRANQADILPDDIYSLGGIAVYLGYGAHRGQHFENDLLAVMRKCRDVCQRLFYGQTEGEATAAATATASAATPQPQTAPRPRMHVIAPRLERNRRRAQR

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

1054 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

116.477 kDa

MRKTLPSIGALGFSNTNAEKDLCCLGWYSNDPDTVVDAPEQAAEILWHLSGTADPDLALNTIIRLMEALGEQKGQLHNALRTDPELRVKLFSLLGASTALGDHLVAHPHTWPELQRPMPTRQEMFRLMLGSVGAARASFSSESQQPQGSDSDSEFSFGADLSADDTANTDLSTPGTYRAEITGERAEVALKTTYRSLLLRIAAADLAGTYPEDIHRTGLPEVPFVTVTKALADLADAALTAALAVAVAHVYPEGEVDTHLAVMAMGKCGAQELNYISDVDVIFVAEPVTPKAIRLAGEFIRIGCACFFEVDAALRPEGKHGVLVRTLDSHVAYYKRWAETWEFQALLKHRPMTGYMPLGQAYSEKLQPMVWEASQRESFVDNVQRMRRRVLENVPAKLKNLELKLGEGGLRDVEFAVQLLQLVHGRSDESLRTLSTIDALNALIEGGYVGREDGAELIRAYEFLRLLEHRLQLQKVKRTHTMPEATKTKQLRWLARAAGFKTSKLASATDEMNAMLKTSRLHISSLHRKLFYRPLLDSVVNISVGTLKLSPAAAKLQLAALGYVFPDRAMDHLHALAAGGSRKAKIQAMLLPTLMEWLSETAEPDAGLLNYRKLSDAAYDRTWFLRMLRDEGVVGQRLMRILGNSPYTADLIISAPDIVKQLGDGATRPKLLETSEDRVTKSIVAAAARHDDPDVAIAVARSLRRAELARIASADLLQMLSVQQVCRRLSYVWDAVLEAGLQAEIRASLIGSTGDKNSVPPARIAVIGMGRLGGSELGYGSDADVMFVCEPTEGVSDEAAVKWAIGVCDSMRSRLAKPSGDPPLDVDLGLRPEGRSGAVVRTLESYKQYYERWGEVWEIQALLRADFIAGDQELGARFLEMIEPLRYPEAGVSQKVIREVRRMKARVDNERLPRGADRNTHTKLGRGALTDVEWTVQLLTMMHAHEFQDLHNPSTLDSLDVIEKHAVIEPEKVEVLRQAWLTATRARNAIVLVRGKRVDQLPQQGTQLAAVAGAAGWEPSDSQQYLDHYLKVTRRARQVVDEVFWGVDSIEHDY

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

1050 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

116.79 kDa

MTDPLIHTRKVMGFVRDPLPTTGALSLKSTNARADLEWLGWRNVESIPLMWALSGAGDPDVALNQLVRMYQTLESQSPQAREELDQRIRADEAFRVRLLALLGGSSAMGDHLVANTHLWELLTEEAPTRAEMFTAMLESVGATPAEVVPVDDEGEERQVANTATEDLTTPGTYRATLTGVDAERALRFTYRTLMMRLAALDLAGTYPNDARRRSQPRVEFTTVTRRLSNLADAALTAALAVAVTGVYGQKPVDARLSVMAMGKCGAQELNYISDVDVIFIAEPAHSRSTRLAAEFIRTGCSSFFEVDAALRPEGKSGALVRTLESHIAYYKRWAETWEFQALLKARPMTGDMDLGQAYLDAIGPMVWTASQRDSFVDDIQAMRRRVLENVPEELRDRELKLGRGGLRDVEFAVQLLQMVHGRYDETLRVRSTVEALQVLVDQGYIGREDGHNLIESYEFLRLLEHRLQLERVKRTHTMPKVEDRMNMRWLARASGFTGSGGQSSARAMEHHLRRVRLQIQSLHSQLFYRPLLNSVVNLSVDAMKLSQEAAKLQLGALGYQHPVRAYEHLTALASGTSRKAKIQAMLLPTLMEWLSQTADPDAGLLNYRKLSDAAYDRSWFLRMLRDEGVVGQRLMRILGTSPYTSELIIATPDFVSELGDGTTGPKLLETAPDRVCKALKATVARHDDPDRAIQAARSLRRQELARVASADLLNLLTVQEVCHSLSLVWDAVLDAALEAEIRAATADPAKPDEPLAAISVIGMGRLGGAELGYGSDADVMFVAEPAPGVDENEAIAWAISVCESMRSRLAKPSGDPPLEVDLGLRPEGRSGAVVRTIESYENYYAKWGETWEVQALLRASWVAGDRELGTRFLETIDKFRYPAGGASDAQIREVRRMKARVDNERLPRGADRNTHTKLGRGALADIEWTVQLLTMLHAHEHPELHNTSTLEVLEVVEEKGIINPLQAQTLREAWLTATAARNALVLVKGKRADQLPPPGRHLAQVAGAAGWDPDEYQEYLDHYLKVTRKSRQVVEEVFWGLDSVEARREL

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

1045 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

116.395 kDa

MSGPLRSERKVVGFVRDPLPKVGSLSLKSEHAQADLEHLGWRNVESLDLLWGLSGAGDPDVALNLLIRLYQALEAIGEDARNELDQEIRQDEKLRVRLFALLGGSSAVGDHLVANPLQWKLLKLDAPSREEMFQALLESVKAQPAVLEVEDFSDAHNIARDDLSTPGFYTASVTGPEAERVLKWTYRTLLTRIAAHDLAGTYPTDMRRKGGDPVPFSTVTMQLSDLADAALTAALAVAIANVYGEKPVDSALSVIAMGKCGAQELNYISDVDVVFVAEPANSKSTRTAAELIRIGSNSFFEVDAALRPEGKSGALVRSLDSHMAYYKRWAETWEFQALLKARPMTGDINLGQSYVDALSPLIWTASQRESFVTDVQAMRRRVLDNVPEDLRDRELKLGRGGLRDVEFAVQLLQMVHGRIDETLRVRSTVNALHVLVDQGYVGREDGHNLIESYEFLRLLEHRLQLERIKRTHLLPKPDDRMNMRWLARASGFTGSMEQSSAKAMERHLRKVRLQIQSLHSQLFYRPLLNSVVNLSADAIRLSPDAAKLQLAALGYLHPSRAYEHLTALASGASRKAKIQAMLLPTLMEWLSQTAEPDAGLLNYRKLSDASYDRSWFLRMLRDEGVVGQRLMRILGNSPYISELIISTPDFMKQLGDAASGPKLLATAPTQVVKAIKATVSRHESPDRAIQAARSLRRQELARIASADLLNMLTVQEVCQSLSLVWDAVLDAALDAEIRAALNDPQKPDQPLANISVIGMGRLGGAELGYGSDADVMFVCEPVAGVEEHEAVTWSIAICDSMRSRLAQPSGDPPLEVDLGLRPEGRSGAIVRTVDSYVKYYEKWGETWEIQALLRAAWVAGDRELGIKFLESIDRFRYPVDGATQAQLREVRRIKARVDNERLPRGADRNTHTKLGRGALTDIEWTVQLLTMMHAHEIPELHNTSTLEVLEVLEKHQIINPVQVQTLREAWLTATAARNALVLVRGKRLDQLPTPGPHLAQVAGASGWDPNEYQEYLENYLKVTRKSRQVVDEVFWGVDSMEQREF

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

1007 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

110.04 kDa

MTREQLSLTVLARAGFVGLSSVRAELEELATLTGFPVDDLLPALLAAADPDTALRLALRLLRRAPDQAAWFLRSWKDARRLLRVIGASEGAAEFFLRQPVELASLHRPVTALPTAAELREDLLDAVGAVGGFASVAEEEAWTALRVRYRRRLVQLASFDLEQDDPVAGFDGVAAALSDLAGAALDASLAVARRQASGSGPGRFPEAEVRATRFAIIGMGKAGARELNYVSDVDVIYVTDGAEDAGVPPGRAVDIATRLAVLTQRGIQDPALEPGLWEVDSNLRPEGRDGALVRTLDSHLAYYDRWAKGWEFQALLKARSLAGDWELGERYVTALAPRVWSSASRENFVESVQRMRERVTDNIPDGDLHYQLKLGPGGLRDVEFTVQLLQLVHGQTDGLVRQRDTLSALAALAGQSYIGREEAAAFSHDYRTLRLLEHRLQLRHLRRTHLMPRDEVEVRILARATGLAASAGQLLTQWNEIKHRVRGLHERLFYRPLLSAVAAMPNEDARLSGEAGLTSEQAQARLAAIGFRDPRGALAHIAALTAGVSRRATIQRHLLPVMLQWFSAGADPDYGLLSFRRLSDDLGGTHWYLRMLRDSSGAAERLTRVLSGSRFVAELLGRIPESVAWLESEEELRPRAPELLREETAAILARHESAETAAAALRAVRRREVLRLAFSGILGFSTIEELARGLSAVTENLLTGVLGAIRAARDDAAALEFAIIGMGRFGGRELGFGSDADIMYVFRPLAAGQDAAHRAATAIVADLNRLTEDSALPVDLDIGLRPEGKNGPSVRSLDSYRAYYARWSLAWEAQALLRARGVAGDSALIGDFETLADEVRYPASIGEQAVREVKRIKARIENERLPQGADPARHLKLGRGSLSDVEWFVQLVQLQHAAAHPALRTPSTLDALAVAAGEGFVSGEDAARLRAAWVFASRARSAMTLWTNKTADVLPFDRVVLDGVARLLEYPPGAASRMEEDYLAVTRRARAVFEREFYGPPQRPATTA

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

1007 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

110.04 kDa

MTREQLSLTVLARAGFVGLSSVRAELEELATLTGFPVDDLLPALLAAADPDTALRLALRLLRRAPDQAAWFLRSWKDARRLLRVIGASEGAAEFFLRQPVELASLHRPVTALPTAAELREDLLDAVGAVGGFASVAEEEAWTALRVRYRRRLVQLASFDLEQDDPVAGFDGVAAALSDLAGAALDASLAVARRQASGSGPGRFPEAEVRATRFAIIGMGKAGARELNYVSDVDVIYVTDGAEDAGVPPGRAVDIATRLAVLTQRGIQDPALEPGLWEVDSNLRPEGRDGALVRTLDSHLAYYDRWAKGWEFQALLKARSLAGDWELGERYVTALAPRVWSSASRENFVESVQRMRERVTDNIPDGDLHYQLKLGPGGLRDVEFTVQLLQLVHGQTDGLVRQRDTLSALAALAGQSYIGREEAAAFSHDYRTLRLLEHRLQLRHLRRTHLMPRDEVEVRILARATGLAASAGQLLTQWNEIKHRVRGLHERLFYRPLLSAVAAMPNEDARLSGEAGLTSEQAQARLAAIGFRDPRGALAHIAALTAGVSRRATIQRHLLPVMLQWFSAGADPDYGLLSFRRLSDDLGGTHWYLRMLRDSSGAAERLTRVLSGSRFVAELLGRIPESVAWLESEEELRPRAPELLREETAAILARHESAETAAAALRAVRRREVLRLAFSGILGFSTIEELARGLSAVTENLLTGVLGAIRAARDDAAALEFAIIGMGRFGGRELGFGSDADIMYVFRPLAAGQDAAHRAATAIVADLNRLTEDSALPVDLDIGLRPEGKNGPSVRSLDSYRAYYARWSLAWEAQALLRARGVAGDSALIGDFETLADEVRYPASIGEQAVREVKRIKARIENERLPQGADPARHLKLGRGSLSDVEWFVQLVQLQHAAAHPALRTPSTLDALAVAAGEGFVSGEDAARLRAAWVFASRARSAMTLWTNKTADVLPFDRVVLDGVARLLEYPPGAASRMEEDYLAVTRRARAVFEREFYGPPQRPATTA

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

1004 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

110.238 kDa

MCCTTVVVVRKPATERLKRPSVGRLGLFDPHAAENLALLGWYDYDCREHVDLLWSLSRAPDADAVLRPMVRLFENPATGWDELNAALLTDRGLRGRLFAVLGSSLALGDHLVAHPQSWKLLRGRVSLPSRTQLHQAFDECVSNFGDDPLDAPDSVLPRLRTLYCDQLLVLAALDLAATVEDEPVLPFTLVAAQLADIADAAMATALRVAEKIVCGDRTPPRLAVIAMGKWGARELNYVSDVDIIFVAEQADPLSTRVASEMMRVASEAFFQVDAGLRPEGRNGELVRTVESHIAYYQRWAKTWEFQALLKARSAVGDAELGERYLAALMPMVWAACERADFVAEVQAMRRRVEQLVPADVRGRELKLGSGGLRDVEFAVQLLQLVHGRSDESLHVVSTVDALAALGEGGYIGREDAANLTASYEFLRLLEHRLQLQRLKRTHLLPEDGDEEAVRWLARAAHIRPDGRHDAAGVLREELKNQNLRVSQLHAKLFYQPLLESIGPASLEIRHGMTSEAAERQLATLGYEGSQTALKHISALVNQSGRRGRVQSVLLPRLLNWMSYAPDPDGGLLAYRRLSEALSAETWYLSTLRDKPAVARRLMHVLGTSVYVPDLLMRAPEVIQSYGDGLAGPKLLEAEPAMVARALITSAGRHTDPIRAIDAARSLRRRELARVGSADLLGLLEVTEVCKALTSVWVAVLQAALDAVIRAYLPDGDKAPAAIAVIGMGRLGGAELGYGSDADVMFVCEPAIGVEDAQALRWSGMIAERVCRLLRTPSVDPPLDVDANLRPEGRNGPLVRTLGAYAAYYAQWAQPWEIQALLRAHAVAGDADLGQRFLLMADKMRYPPDGVSAEAVREIRRMKARVEAERLPRGADPHTHTKLGRGGLADIEWTVQLMQLRHAHELPALHKTSTLESLDAIAAANLIPEADVDLLRQAWLTATRARNALVLVRGKTTDQLPGPGRQLNAVAVAAGWPSDDGSEFLDNYLRVTRRAKTFVRKVFGS

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

1004 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

109.461 kDa

MVRPPSARSAVPGVGRLGLLDPTAAASLRELGWDNVESIPVLWALSRAPDADLALNTLMRLREALGSDWQRLDSAIRTDTSLRGRLFALLGSSTALGDHLVAEPAAWEVLRRGDLPDRDELLADLLAAVQATPEAGPHAGPMLFRAGIAGPEAVALLRCRYRDQLMLLAALDLAATVENEPVLPYRVVGRHLTDLADAALTAALAVAVARVCKDQPCPVRLAVIAMGKCGARELNYVSDVDVVFVAEPADATATRLAAEMMSVGSQAFFEVDAALRPEGKQGALVRTLDSHLTYYKRWARTWEFQALLKNRPMTGDLELGREYRDAVMPMVWTASERPDFVPEVQGMRRRVEDLVPAELRERELKLGRGSLRDVEFAVQLLQLVHGRVDENLHVASTVDALSALAAGGYVGRDDAANLTASYEFLRLLEHRLQLQRLKRTHTLPADDDEEGMRWLARAAHIRPDGRQDAMGVLRSEIRRNAVRVRRLHAKLFYRPLLEAVVRMDPDALRLSPDAAVRQLAALGYAAPENAFGHLKALTGGVSRKGRIQALLLPTLLEWLGETPNPDAGLLAYRRVSEALDEQTWFLRELRDEGAVAQRLMIVLGSSEFLPDLLINAPETIRMFADGPHGPLLLGPQPEEVARGILTAAARYDDPNRAVAAARSLRRHELARVASADLLGMLEVPQVCRALSSVWVAVLDAALAAVIRAGEAESGEPAPAAFAVIGMGRLGGMELGYGSDADVLFVCEPRPGVDETKAVKWANTVAERVQRLLGAPSTDPPLHVDAGLRPEGRSGALVRTLSAYQAYYGQWAQSWEVQALLRAHQVAGDQELGVRFLHAVDKVRYPAGGVSEDAVREIRRIKARVDSERLPRGADPATHTKLGRGGLADIEWTVQLLQLRHAHEVESLHNTATLETLAAIEKAELLAAEDVALLRDSWLLATKARNALVLVRGKPSDQLPGPGRLLSAVATVAGWPNNDGGSEFLDHYLRITRRARAVVERVFGS

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

1000 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.701 kDa

MTAPGRRSSTFSRLLRHGFTDPSAAERLLESAELEPVKADPVLLEALGATADPDLALLGLVRLVEAQDDHTARRELLDTLIAAKPLRDRLLGVLGASAALADHLARHPRDWQALVTYEPRDLHPGVEEFERGLAEAADPVSLRVAYRRCLLSIAARDVCGTTDLAQTAAELADLATATLRAALLIARTAAPDDAAICRLAVIAMGKCGGHELNYVSDVDVIFVGEPANGADEGKAVQAATRLASHMMRICSETTVEGTIWPVDANLRPEGRNGPLVRTLSSHLAYYQRWAKTWEFQALLKARPVAGDIGLGEEYVATLAPLVWQAAERDNFVADVQKMRRRVVANIPAAEIERELKLGPGGLRDVEFAVQLLQLVHGRADASLRSGTTLDALKALAAGGYVGRADAVQLDEAYRFLRTMEHRIQLFRLRRTHLVPEDDADLRRIGRSLGLRADPITDLNREWKRHATVVRRLHEKLFYRPLLDAVAQLAPGEARLSPNAARERLVALGYADPAAALRHLEALASGVTRKAAIQRTLLPVLLGWFADSADPDAGLLNFRKVSDALGKTPWYLRLLRDEGAAAENLARVLSAGRLAPDLLMRAPEAVALLGDGDGGRGGLEPRGRAQLEQEVLAAVGRAGGSEQAVTTVRGVRRRELFRTAARDIVSSYGTEETPAEADQGALVDLVGGAVSDLTAATLAGTLRAVVREGWGDTLPTRFAVVGMGRFGGYELGYGSDADVLFVHEPREGVDEQEAARAANAVVSEMRRLLQIPSADPPLLIDADLRPEGKSGPTVRTLTSYEAYYRRWSLVWESQALLRAEFVAGDEELGQRFIELIDPFRYPAEGLGDDAVREIRRLKARMEAERLPRGADPTLHTKLGRGGLSDVEWTVQLLQLQHGWVEPGLRTTRTRPALAAACAAGLLTGEDAAILDEAWVLATRVRNAVMLVRGRAGDTFPSDGRELAAVGRYLGYGPGHVGDMLDDYRRITRRARAVVDEQFYGA

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

999 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.777 kDa

MTPGRRSSTFTRLLRHGFTDPSAAERLLDGAGLAELRADPVLLEALGATADPDLALHGLVRLLEAQPDATARQELLDTLIAAKPLRDRLLGVLGASEALADHLARHAGDWQTLVTYEPRDLHRGVEEFERGLAEATDPVTLRVAYRRCLLSIAARDVCGTIDVAETAAELADLAIATLRAALALAEAAAPEDAARCRLAVIAMGKCGGHELNYVSDVDVIFVGEAADTGPDADEAKAMRAATSLAAHMMRICSETTVEGSIWPVDANLRPEGRNGPLVRTLSSHVAYYQRWAKTWEFQALLKARPVAGDPGLGAEYVAALQPLVWQAADRENFVPDVQKMRRRVVENIPLTEVDRQLKLGPGGLRDVEFAVQLLQLVHGRADTSLHSGTTLDALEALAAGGYVGRTDAAQLDEAYRFLRSMEHRIQLHRLRRTHLVPEDEADLRRLGRSLGLRTDPVTGLLRAWKRHASVVRRLHEKLFYRPLLDAVAQLAPGEARLSPEAARERLVALGYADPAAALRHLEALASGVTRKAAIQRTLLPVLLGWFADSADPDTGLLNFRKVSDALGTTPWYLRLLRDEGAAAENLARVLSAGRLAPDLLMRAPEAVALLGDGVAGGLRPRDRAQLEQETLAAVRRADDAVQAVTAVRGVRRRELFRTAAADIVGSYGTETQPVEADQGALVDLVGGAVSDLTSATLAGTLRAVVREKWGDVLPTRFAIIGMGRFGGHELGYGSDADVLFVHEPRDGVAEREAGDAANKVVSEMRRLLQVPSADPPLLIDADLRPEGRSGPLVRTLKSYEAYYRRWSLGWESHALLRAEFVAGDEELGRRFIELIDPLRYPEGGLGEDAVREIRRLKARMESERLPRGADPKLHAKLGPGGLSDVEWTVQLLQLRHGHEIAGLRTTRTRTALAAARDAGLISEEHTATLDEAWVLATRVRNAVMLVRGRAGDTFPTDPRELAAVGRYLGHGSGHAGDMLDEYRRTARRARTVVEDLFYA

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

999 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

109.4 kDa

MFVRKPATERPRLPSVGRLGLFDPHAPAHLDQLGWNTDDHVELLWSLSRAPDADAALLAMVRLADELKDDWDELNRLLLTDRPLRGRLFAVLGSSLALGDHLVAHPQSWRLLHGDVRLPSARELRETFDDAARSVDIERGASAAIPPLRDLYRDRLLVLAALDVASTVENEPVLPFVTVSAHLSDLADAALSAALIVATRTVCGDLDPRLAVIAMGKCGARELNYVSDVDVIFVGEDIEKDGRSDNLATATRVAGEMMRFAGDAFFEVDAALRPEGKRGQLVRTLDSHVAYYRRWAKTWEFQALLKARPAAGDPELGQAYIDALMPMVWTACEREDFVPEVQAMRRRVEELVPADVRSREIKLGTGGLRDVEFAVQLLQLVHGRTDESLHVASTVDALAALGEGGYVGRDDAANMTASYEFLRLLEHRLQLQRLKRTHMLPDDNDDEAYRWLARAAHIRPDGTHDAQGVLREELKRQSLRVSRLHAKLFYQPLLESVGHTALGIGEGMSAEAAERQLAALGYERPQSALAHLAALTGATGRKGRIQQILLPTLLDWLSDTPDPDAGLLAYRRLSDEHSDLRWFLGTLRDEGAVAKRLMRVLGTSAYIPELLMRAPEVIQMYADGPSGPKLLEDDRESRARALVASASRYADPVRAIAAARTLRRRELARIASADVLGMLDVIDVCKSLTAVWVAVLQAALDVVIRANTPDSGVPARIAVIGMGRLGGGELGYGSDADVMFVCEPNSGVEESVAVRWSVGVAEQVRALLGTPSADPPLEVDTGLRPEGRSGPLVRTLASYDAYYSQWAQPWEIQALLRAHRVAGDLELGERFLLMADKIRYPEGGVSASAVQEIRRIKARVDAERLPRGADPNTHTKLGRGGLADIEWTVQLLQLRYAHKVPALHNTSTLEALNAIGAAELVAEGDVELLREAWLTATRARNALVLVRGKPTDQLPGPGRQLNAVALAAGWGSDDGGEFLDNYLRVTRRAKAVVRKIFGG

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

998 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.705 kDa

MVVTKPATQRPRLPSVGRLGLVDPQAAERMAQLGWYDHDDQAHVDLLWALSRAPDPDAALLALVRLAETPDAGWDELGAALLTERPLRGRLFAVLGSSLALGDHLVAQPRSWKLLRGNVSLPTHDELCAMFTGCVDEALADPGSAMVRLRTLYRDRLLVLAALDLAATVEDEPVLPFTVVAAHLSDLADAALAAALRVAEHNVCGDRTPPRLAVIAMGKCGARELNYVSDVDVIFVGERADTVTTRVASEMMRLASEAFFQVDAGLRPEGRSGELVRTVESHIAYYQRWAKTWEFQALLKARAAVGDAELGRRYLDALMPMVWVACEREDFVVEVQAMRRRVEQLVPADVRGREIKLGSGGLRDVEFAVQLLQLVHGRSDESLHVASTVDALAALGQGGYIGREDAANLTASYEFLRLLEHRLQLQRLKRTHLLPEADDEEAVRWLARAAHIRPDGRHDAAGVLREELRHQNLRVSQLHAKLFYQPLLESIGPAGLEIRHGMTSEAAERQLAALGYEGPQSALKHMSALVNQSGRRGRVQSVLLPRLLNWMSYAPDPDGGLLAYRRLSEALAGESWYLSTLRDKPAVARRLMHVLGTSAYVPDLLMRAPRVIQDYGDGPSGPRLLETDPAAVARALVASASRYSDPVRAIAGARTLRRRELARVASADLLGMLEVTDVCKALTSVWVAVLQAALDAMIRANLPDDGPQRGKAPAAIAVIGMGRLGGAELGYGSDADVMFVCEPAPGVDDSAAVRWAASVAEQVRTLLGTPSVDPPLDVDANLRPEGRNGPLVRTLASYAAYYEQWAQPWEIQALLRAHAVAGDAELGQRFLLMADKTRYPADGVSPEAVREIRRIKARVDAERLPRGADPNTHTKLGRGGLADIEWTVQLLQLLHAHEVPALHNTSTLECLDAIAEAGLVPADEVDLLRQAWLTATRARNALVLVRGKPTDQLPGPGRQLNAVAVAAGWPTDEGGEFLDNYLRVTRRAKAVVRKVFGS

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

998 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.705 kDa

MVVTKPATQRPRLPSVGRLGLVDPQAAERMAQLGWYDHDDQAHVDLLWALSRAPDPDAALLALVRLAETPDAGWDELGAALLTERPLRGRLFAVLGSSLALGDHLVAQPRSWKLLRGNVSLPTHDELCAMFTGCVDEALADPGSAMVRLRTLYRDRLLVLAALDLAATVEDEPVLPFTVVAAHLSDLADAALAAALRVAEHNVCGDRTPPRLAVIAMGKCGARELNYVSDVDVIFVGERADTVTTRVASEMMRLASEAFFQVDAGLRPEGRSGELVRTVESHIAYYQRWAKTWEFQALLKARAAVGDAELGRRYLDALMPMVWVACEREDFVVEVQAMRRRVEQLVPADVRGREIKLGSGGLRDVEFAVQLLQLVHGRSDESLHVASTVDALAALGQGGYIGREDAANLTASYEFLRLLEHRLQLQRLKRTHLLPEADDEEAVRWLARAAHIRPDGRHDAAGVLREELRHQNLRVSQLHAKLFYQPLLESIGPAGLEIRHGMTSEAAERQLAALGYEGPQSALKHMSALVNQSGRRGRVQSVLLPRLLNWMSYAPDPDGGLLAYRRLSEALAGESWYLSTLRDKPAVARRLMHVLGTSAYVPDLLMRAPRVIQDYGDGPSGPRLLETDPAAVARALVASASRYSDPVRAIAGARTLRRRELARVASADLLGMLEVTDVCKALTSVWVAVLQAALDAMIRANLPDDGPQRGKAPAAIAVIGMGRLGGAELGYGSDADVMFVCEPAPGVDDSAAVRWAASVAEQVRTLLGTPSVDPPLDVDANLRPEGRNGPLVRTLASYAAYYEQWAQPWEIQALLRAHAVAGDAELGQRFLLMADKTRYPADGVSPEAVREIRRIKARVDAERLPRGADPNTHTKLGRGGLADIEWTVQLLQLLHAHEVPALHNTSTLECLDAIAEAGLVPADEVDLLRQAWLTATRARNALVLVRGKPTDQLPGPGRQLNAVAVAAGWPTDEGGEFLDNYLRVTRRAKAVVRKVFGS

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

998 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.601 kDa

MVVTKPATQRPRLPSVGRLGLVDPQAAERMAQLGWYDHDDQAHVDLLWALSRAPDPDAALLALVRLAETPDAGWDELGAALLTERPLRGRLFAVLGSSLALGDHLVAQPRSWKLLRGNVSLPTHDELCAMFTGCVDEALADPGSAMVRLRTLYRDRLLVLAALDLAATVEDEPVLPFTVVAAHLSDLADAALAAALRVAEHNVCGDRTPPRLAVIAMGKCGARELNYVSDVDVIFVGERADTVTTRVASEMMRLASEAFFQVDAGLRPEGRSGELVRTVESHIAYYQRWAKTWEFQALLKARAAVGDAELGRRYLDALMPMVWVACEREDFVVEVQAMRRRVEQLVPADVRGREIKLGSGGLRDVEFAVQLLQLVHGRSDESLHVASTVDALAALGQGGYIGREDAANLTASYEFLRLLEHRLQLQRLKRTHLLPEADDEEAVRWLARAAHIRPDGRHDAAGVLREELRHQNLRVSQLHAKLFYQPLLESIGPAGLEIRHGMTSEAAERQLAALGYEGPQSALKHMSALVNQSGRRGRVQSVLLPRLLNWMSYAPDPDGGLLAYRRLSEALAGESWYLSTLRDKPAVARRLMHVLGTSAYVPDLLMRAPRVIQDYGDGPSGPRLLETDPAAVARALVASASRYSDPVRAIAGARTLRRRELARVASADLLGMLEVTDVCKALTSVWVAVLQAALDAMIRANLPDDGPQRGKAPAAIAVIGMGRLGGAELGYGSDADVMFVCEPAPGVDDSAAVRWAASVAEQVRTLLGTPSVDPPLDVDANLRPEGRNGPLVRTLASYAACYEQWAQPWEIQALLRAHAVAGDAELGHRFLLMADKTRYPADGVSPEAVREIRRIKARVDAERLPRGADPNTHTKLGRGGLADIEWTVQLLQLLHAHEVPALHNTSTLECLDAIAEAGLVPADEVDLLRQAWLTATRARNALVLVRGKPTDQLPGPGRQLNAVAVAAGWPTDEGGEFLDNYLRVTRRAKAVVCKVFGS

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

995 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

110.119 kDa

MNHSAPGNADKHGESLAARFAEAPHIAASTTDERRFESWLAELEPAQSARLEALLVQPFGRNILVGIAEFSPYLFDLVRADPLRLIRLLECDPDTHLAALIAEARGAVLAAPDEAEVMRLLRRMKAEAALLTALCDIGGVWPVMRVTSALTDVAVSSVQAALQYLLRQEAARGKLFPPNPEAPEEGCGLIVLAMGKMGAGELNYSSDIDLIVFFDPDATTLAPDIEPQPFFVRVTQGMARILQQRTYDGYVFRVDLRLRPDPSSTQVAISRDAALHYYEREGRTWERAAMIKARACAGDARAGEALLAEIAPFVWRKHLDFAALADVHDMKRQMQTYRGQSEVAVEGHNVKVGRGGIREIEFFAQTQQLIAGGRHPELRVRPTLAALDVLASSNWITLAARDELARAYEFLRRVEHRLQMVADEQTHALPDDREAVERFARFFGYPDREAFARDLLRQLEIVQGHYEKLFEGDDPTGTAKLPALDYSAGPDDPRLFQHLTTLGFKKPAAVAQTVRDWITGDYRVFRNEATRSAFIEFVPALIDGLALAEEPDRAVVAFDQFLGALQRGGRLITLLGQNRDLVALVALVLGAAPRLGEMLARQPQLMDGLIDPRFFGAMPDRRELSGRLAATVQDAASYEEFLDRLRLFGQESLFLIGTRILSGTVSAQQASTAFADVAEGVVHTVHDLVADRFAAQHGRIKGQETAIIAMGRLGSREMTASSDLDLILLYDFDSENPDSDGPKSLQGAHYFARFTQRLISAFTTRTNYGVLYEIDMRLRPSGRAGPVASSLASFADYQANEAWTWEHMALTRARVVSASAEFGERIAGVIRDVLTRRRDPATIANDVADMRRAIAQEKGETDYWDLKYAAGGMIDIDFIAQYLQLVHAHHKPDILDVSTLQVLDNAARLGVLPQSEAEILRAAARLYHDLTQILRLCVSDRFKPETAGTDLQRVMARAGDAPDFSSLEARVKETQSEVRRVFRALLEGTSPASAR

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

995 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

110.119 kDa

MNHSAPGNADKHGESLAARFAEAPHIAASTTDERRFESWLAELEPAQSARLEALLVQPFGRNILVGIAEFSPYLFDLVRADPLRLIRLLECDPDTHLAALIAEARGAVLAAPDEAEVMRLLRRMKAEAALLTALCDIGGVWPVMRVTSALTDVAVSSVQAALQYLLRQEAARGKLFPPNPEAPEEGCGLIVLAMGKMGAGELNYSSDIDLIVFFDPDATTLAPDIEPQPFFVRVTQGMARILQQRTYDGYVFRVDLRLRPDPSSTQVAISRDAALHYYEREGRTWERAAMIKARACAGDARAGEALLAEIAPFVWRKHLDFAALADVHDMKRQMQTYRGQSEVAVEGHNVKVGRGGIREIEFFAQTQQLIAGGRHPELRVRPTLAALDVLASSNWITLAARDELARAYEFLRRVEHRLQMVADEQTHALPDDREAVERFARFFGYPDREAFARDLLRQLEIVQGHYEKLFEGDDPTGTAKLPALDYSAGPDDPRLFQHLTTLGFKKPAAVAQTVRDWITGDYRVFRNEATRSAFIEFVPALIDGLALAEEPDRAVVAFDQFLGALQRGGRLITLLGQNRDLVALVALVLGAAPRLGEMLARQPQLMDGLIDPRFFGAMPDRRELSGRLAATVQDAASYEEFLDRLRLFGQESLFLIGTRILSGTVSAQQASTAFADVAEGVVHTVHDLVADRFAAQHGRIKGQETAIIAMGRLGSREMTASSDLDLILLYDFDSENPDSDGPKSLQGAHYFARFTQRLISAFTTRTNYGVLYEIDMRLRPSGRAGPVASSLASFADYQANEAWTWEHMALTRARVVSASAEFGERIAGVIRDVLTRRRDPATIANDVADMRRAIAQEKGETDYWDLKYAAGGMIDIDFIAQYLQLVHAHHKPDILDVSTLQVLDNAARLGVLPQSEAEILRAAARLYHDLTQILRLCVSDRFKPETAGTDLQRVMARAGDAPDFSSLEARVKETQSEVRRVFRALLEGTSPASAR

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

995 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.542 kDa

MNVTKPATQRPKLPSVGRLGLVDALAGARLAELGWTEHDDQAHVDLLWSLSRAPDADAALKVLVRLAENPDTGWDELNAALLNERSLRGRLFAVLGSSLSLGDHLVANPQSWKLLRGKVALPSHAALLESFVDLAEEVAAAPASAVHRLRALHRDHVLVLAGLDLAATVEDEPVLPFTVVAAHLADIADAALAAALRLAEKTVCRDRTPPRLAVIAMGKCGARELNYVSDVDVIFVAERADPISIRVAGEMMRVASSTFFEVDAGLRPEGRSGELVRTVESHIAYYQRWAKTWEFQALLKARAAVGDAELGQSYLAALMPMVWTACERDDFVAEVQAMRRRVEQLVPADIRGRELKLGTGGLRDVEFVAQLLQLVHGRSDESLHVASTVDALSALGEGGYIGREDAANMIASYEFLRLLEHRLQLQRLKRTHLLPEFDDEEAVRWLARAAHIRPDGRHDAAGMLREELKHQNVRVSRLHAKLFYQPLLESIAPAGLEIAGRGMTSEAAERQLAALGYEGPQTALKHMAALVNHSGRRARVQSVLLPRLLDWLSYAPDPDGGLLAYRRLSEALATQSWYLSTLRDKPTVGRRLMHVLGTSAFVPDLLMRAPEVIQNYGDGRTGPKLLETEPAAVARALIASAGRYSDPLRAIAAARTLRRRELARIGSADLLGLLEVTEVCRALTSVWVAVLQSALEAMIRANTPEGGRPLARIAVIGMGRLGGSELSYGSDADVMYVCEPASGVTDAQAVKWSTAVAEQVRAKLGTPSVDPPLEVDANLRPEGRNGPLVRTLASYEAYYAQWAQAWEIQALLRAHAVAGDAELGQRFLLLVDHTRYPPDGVSAEAVHEIRRIKARVESERLPRGADPNTHTKLGRGGLADIEWTVQLLQLQNAHEIEALHNTSTLESLDAIAEAKLVAEDEVKLLRQAWLTATRARNALVLVRGKPTDQLPGPGRQLNAVAVAAGWHNDDGGEFLDNYLRVTRRAKAVVRKVFGS

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

995 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.432 kDa

MNVTKPATQRPKLPSVGRLGLVDALAGAHLAELGWTEHDDQAHVDLLWSLSRAPDADAALKVLVRLAENPDTGWDELNAALLNERSLRGRLFAVLGSSLSLGDHLVANPQSWKLLRGKVALPSHAALLESFVDLAEEVAAAPASAVHRLRALHRDHVLVLAGLDLAATVEDEPVLSFTVVAAHLADIADAALAAALRLAEKTVCRDRTPPRLAVIAVGKCGARELNYVSDVDVIFVAERADPISIRVAGEMMRVASSTFFEVDAGLRPEGRSGELVRTVESHIAYYQRWAKTWEFQALLKARAAVGDAELGQRYLAALMPMVWTACERDDFVAEVQAMRRRVEQLVPADIRGRELKLGTGGLRDVEFVAQLLQLVHGRSDESLHVASTVDALSALGEGGYIGREDAANMIASYEFLRLLEHRLQLQRLKRTHLLPEFDDEEAVRWLARAAHIRPDGRHDAAGMLREELKHQNVRVSRLHAKLFYQPLLESIAPAGLEIAGRGMTSEAAERQLAALGYEGPQTALKHMAALVNHSGRRARVQSVLLPRLLDWLSYAPDPDGGLLAYRRLSEALAPQSWYLSTLRDKPTVGRRLMHVLGTSAFVPDLLMRAPEVIQNYGDSRTGPKLLETEPAAVARALIASAGRYSDPLRAIAAARTLRRRELARIGSADLLGLLEVTEVCRALTSVWVAVLQSALEAMIRANTPEGGRPLARIAVIGMGRLGGSELSYGSDADVMYVCEPASGVTDAQGVKWSTAVAEQVRAKLGTPSVDPPLEVDANLRPEGRNGPLVRTLASYGAYYAQWAQAWEIQALLRAHAVAGDAALGQRFLLLVDHTRYPPDGVSAEAVHEIRRIKARVESERLPRGADPNTHTKLGRGGLADIEWTVQLLQLQNAHEIEALHNTSTLESLDAIAEAKLVAEDEVKLLRQAWLTATRARNALVLVRGKPTDQLPGPGRQLNAVAVAAGWHNDDGGEFLDNYLRVTRRAKAVVRKVFGS

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

994 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

109.138 kDa

MVVTKLATQRPKLPSVGRLGLVDPPAGERLAQLGWDRHEDQAHVDLLWSLSRAPDADAALRALIRLSENPDTGWDELNAALLRERSLRGRLFSVLGSSLALGDHLVAHPQSWKLLRGKVTLPSHDQLQRSFVECVEESEGMPGSLVHRLRTQYRDYVLMLAALDLAATVEDEPVLPFTVVAARLADAADAALAAALRVAEASVCGEHPPPRLAVIAMGKCGARELNYVSDVDVIFVAERSDPRNARVASEMMRVASAAFFEVDAALRPEGRNGELVRTLESHIAYYQRWAKTWEFQALLKARPVVGDAELGERYLTALMPMVWRACEREDFVVEVQAMRRRVEQLVPADVRGRELKLGSGGLRDVEFAVQLLQLVHARSDESLRVASTVDALAALGEGGYIGREDAANMTASYEFLRLLEHRLQLQRLKRTHLLPDPEDEEAVRWLARAAHIRPDGRNDAAGVLREELKKQNVRVSKLHTKLFYQPLLESIGPTGLEIAHGMTLEAAGRRLAALGYEGPQTALKHMSALVNQSGRRGRVQSVLLPRLLDWMSYAPDPDGGLLAYRRLSEALATESWYLATLRDKPAVAKRLMHVLGTSAYVPDLLMRAPRVIQQYEDGPAGPKLLETEPAAVARALIASASRYPDPERAIAGARTLRRRELARIGSADLLGLLEVTEVCRALTSVWVAVLQAALDVMIRASLPDDDRAPAAIAVIGMGRLGGAELGYGSDADVMFVCEPATGVDDARAVKWSTSIAERVRALLGTPSVDPPLELDANLRPEGRNGPLVRTLGSYAAYYEQWAQPWEIQALLRAHAVAGDAELGQRFLRMVDKTRYPPDGVSADSVREIRRIKARIESERLPRGADPNTHTKLGRGGLADIEWTVQLLQLQHAHQVPALHNTSTLQSLDVIAAADLVPAADVELLRQAWLTATRARNALVLVRGKPTDQLPGPGRQLNAVAVAAGWRNDDGGEFLDNYLRVTRRAKAVVRKVFGS

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

994 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

109.124 kDa

MVVTKLATQRPKLPSVGRLGLVDPPAGERLAQLGWDRHEDQAHVDLLWSLSRAPDADAALRALIRLSENPDTGWDELNAALLRERSLRGRLFSVLGSSLALGDHLVAHPQSWKLLRGKVTLPSHDQLQRSFVECVEESEGMPGSLVHRLRTQYRDYVLMLAALDLAATVEDEPVLPFTVVAARLADAADAALAAALRVAEASVCGEHPPPRLAVIAMGKCGARELNYVSDVDVIFVAERSDPRNARVASEMMRVASAAFFEVDAALRPEGRNGELVRTLESHIAYYQRWAKTWEFQALLKARPVVGDAELGERYLTALMPMVWRACEREDFVVEVQAMRRRVEQLVPADVRGRELKLGSGGLRDVEFAVQLLQLVHARSDESLRVASTVDALAALGEGGYIGREDAANMTASYEFLRLLEHRLQLQRLKRTHLLPDPEDEEAVRWLARAAHIRPDGRNDAAGVLREELKKQNVRVSKLHTKLFYQPLLESIGPTGLEIAHGMTLEAAGRRLAALGYEGPQTALKHMSALVNQSGRRGRVQSVLLPRLLDWMSYAPDPDGGLLAYRRLSEALATESWYLATLRDKPAVAKRLMHVLGTSAYVPDLLMRAPRVIQQYEDGPAGPKLLETEPAAVARALIASASRYPDPERAIAGARTLRRRELARIGSADLLGLLEVSEVCRALTSVWVAVLQAALDVMIRASLPDDDRAPAAIAVIGMGRLGGAELGYGSDADVMFVCEPATGVDDARAVKWSTSIAERVRALLGTPSVDPPLELDANLRPEGRNGPLVRTLGSYAAYYEQWAQPWEIQALLRAHAVAGDAELGQRFLRMVDKTRYPPDGVSADSVREIRRIKARIESERLPRGADPNTHTKLGRGGLADIEWTVQLLQLQHAHQVPALHNTSTLQSLDVIAAADLVPAADVELLRQAWLTATRARNALVLVRGKPTDQLPGPGRQLNAVAVAAGWRNDDGGEFLDNYLRVTRRAKAVVRKVFGS

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

994 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

109.138 kDa

MVVTKLATQRPKLPSVGRLGLVDPPAGERLAQLGWDRHEDQAHVDLLWSLSRAPDADAALRALIRLSENPDTGWDELNAALLRERSLRGRLFSVLGSSLALGDHLVAHPQSWKLLRGKVTLPSHDQLQRSFVECVEESEGMPGSLVHRLRTQYRDYVLMLAALDLAATVEDEPVLPFTVVAARLADAADAALAAALRVAEASVCGEHPPPRLAVIAMGKCGARELNYVSDVDVIFVAERSDPRNARVASEMMRVASAAFFEVDAALRPEGRNGELVRTLESHIAYYQRWAKTWEFQALLKARPVVGDAELGERYLTALMPMVWRACEREDFVVEVQAMRRRVEQLVPADVRGRELKLGSGGLRDVEFAVQLLQLVHARSDESLRVASTVDALAALGEGGYIGREDAANMTASYEFLRLLEHRLQLQRLKRTHLLPDPEDEEAVRWLARAAHIRPDGRNDAAGVLREELKKQNVRVSKLHTKLFYQPLLESIGPTGLEIAHGMTLEAAGRRLAALGYEGPQTALKHMSALVNQSGRRGRVQSVLLPRLLDWMSYAPDPDGGLLAYRRLSEALATESWYLATLRDKPAVAKRLMHVLGTSAYVPDLLMRAPRVIQQYEDGPAGPKLLETEPAAVARALIASASRYPDPERAIAGARTLRRRELARIGSADLLGLLEVTEVCRALTSVWVAVLQAALDVMIRASLPDDDRAPAAIAVIGMGRLGGAELGYGSDADVMFVCEPATGVDDARAVKWSTSIAERVRALLGTPSVDPPLELDANLRPEGRNGPLVRTLGSYAAYYEQWAQPWEIQALLRAHAVAGDAELGQRFLRMVDKTRYPPDGVSADSVREIRRIKARIESERLPRGADPNTHTKLGRGGLADIEWTVQLLQLQHAHQVPALHNTSTLQSLDVIAAADLVPAADVELLRQAWLTATRARNALVLVRGKPTDQLPGPGRQLNAVAVAAGWRNDDGGEFLDNYLRVTRRAKAVVRKVFGS

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

990 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

113.727 kDa

MPTDNENSMTNVEQAEKYWQQFLTAPALTDDDKAIAKQHHDVLLTAFARSSFLAETIIQKPSFVSRTVEQTVEQTVEQTTEQDSDEQLQKNVDKEASSPWVAMYRSALDITLETVKTEDDLLKALREYRNQEMARVTFLDVLNKQDISTSLERVSALADVLLTGAYHWIYQHLAIRYGTPQNNGEDMHMYILGMGKLGGKELNFSSDIDLIFSYPEKGETQGGRKSIEHQQFFTKLAQKLIQALNKITNDGQVYRVDMRLRPFGDSGPLVMHFAALEDYYQDQGRHWERFAMVKARVINDDNSEDVKWLNSILHPFTFRRYLDFTTLDALRNMKKLIATEIRRRRLNNNIKLGAGGIREVEFFAQSFQLIHGGREPALQSKSLLRTLDALTELDIVEKDVTEQLKHDYLFLRKVEHTLQQCQDRQTQTLPDSAWQQAALIEVMGFDSYSTFLNQLDATMARIHGHFNELVEESQDSHSDEDQLFIACQDAWRLSLQEEEFAETFSEHLSSKDITGVYPILVAFKDKQRNYRIGQKGEDTLNKLLPEILYVLINQHPNHISQVLKRLLGVIEAITGRTTYLDLLLENPDVLKQLVKLCERSDWIAQEIKRFPLLLDELLTPLYLGQQNTDIHTSKKEYQLELRETMLRIEQDDVEMLMDGLRQFKLCQQLRIAASDISESLPVNNVSDKLTVLAEVILEHVVNAAWMQMRQRYGVPSHLEGNDKGFAVIGYGKLGGYELGYGSDLDLVFLHNAPRGISTDGNKSLEAQQFYIKLAQRIMHLLNTKTLFGQLYETDLRLRPSGNAGLLCCHIDGFEKYQTEEAWTWEHQALVRARAICGDVGLLKDFTRVRHTILSQVRDSKSLATDVCKMRLKMREHLLSKNNDKVDLKQCVGGITDIEFMAQYLVLANAQSADSMTTYPDNLRIFDTAVKARIIDPSTASKLQKAYLKLREQYHHLTLADTKYADQSEELDAIREQVRQHWDTLFGTCSE

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

990 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

113.727 kDa

MPTDNENSMTNVEQAEKYWQQFLTAPALTDDDKAIAKQHHDVLLTAFARSSFLAETIIQKPSFVSRTVEQTVEQTVEQTTEQDSDEQLQKNVDKEASSPWVAMYRSALDITLETVKTEDDLLKALREYRNQEMARVTFLDVLNKQDISTSLERVSALADVLLTGAYHWIYQHLAIRYGTPQNNGEDMHMYILGMGKLGGKELNFSSDIDLIFSYPEKGETQGGRKSIEHQQFFTKLAQKLIQALNKITNDGQVYRVDMRLRPFGDSGPLVMHFAALEDYYQDQGRHWERFAMVKARVINDDNSEDVKWLNSILHPFTFRRYLDFTTLDALRNMKKLIATEIRRRRLNNNIKLGAGGIREVEFFAQSFQLIHGGREPALQSKSLLRTLDALTELDIVEKDVTEQLKHDYLFLRKVEHTLQQCQDRQTQTLPDSAWQQAALIEVMGFDSYSTFLNQLDATMARIHGHFNELVEESQDSHSDEDQLFIACQDAWRLSLQEEEFAETFSEHLSSKDITGVYPILVAFKDKQRNYRIGQKGEDTLNKLLPEILYVLINQHPNHISQVLKRLLGVIEAITGRTTYLDLLLENPDVLKQLVKLCERSDWIAQEIKRFPLLLDELLTPLYLGQQNTDIHTSKKEYQLELRETMLRIEQDDVEMLMDGLRQFKLCQQLRIAASDISESLPVNNVSDKLTVLAEVILEHVVNAAWMQMRQRYGVPSHLEGNDKGFAVIGYGKLGGYELGYGSDLDLVFLHNAPRGISTDGNKSLEAQQFYIKLAQRIMHLLNTKTLFGQLYETDLRLRPSGNAGLLCCHIDGFEKYQTEEAWTWEHQALVRARAICGDVGLLKDFTRVRHTILSQVRDSKSLATDVCKMRLKMREHLLSKNNDKVDLKQCVGGITDIEFMAQYLVLANAQSADSMTTYPDNLRIFDTAVKARIIDPSTASKLQKAYLKLREQYHHLTLADTKYADQSEELDAIREQVRQHWDTLFGTCSE

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

990 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

109.348 kDa

MIFSAITADLDNTALAARFGAGPRLYDPVLAAERWAGWLADLAPEQADAIAALGNAFPDLQIALQSIAEASPYLFDLIRGDPVRLLRVLRGAPEQRLAKLLEDAETFVAAASAEDEVMAALRRLKAEAALLIALCDIGGIWPVMQVTQALTDLAGRSVQMALRFLLRQEAGRGRIVPPNPDCPEQGSGLIVLAMGKMGAGELNYSSDIDLIVFYELDAPTLAPDIEPQPFFVRVTQGLSRILQQRRGDGYVFRVDLRLRPDPASTPVALSTVSALDYYEREGRTWERAAMIKARPCAGDLVAGDALLSEIAPFVWRKHLDFAALSDVHDMKRQMQTYRGQTEIAVEGHNVKVGRGGIREIEFFAQTQQLIAGGRHPELRVRPTLEALEILAARNWITLQARDELTEAYLFLRKVEHRVQMIADEQTHALPDTVEAIEQFSRFLGYDSRDSFARDLLGYLERVQGHYAKLFEGDPTGTAKLPPVDYGAGPEDTRLLDHLLSLGYKKPLMIATTLQQWMTGGYRVLKVETTQRAFREFVPALIEELARAEQPDDAVNAFDRLLQALHRGGRLISLLSQNRELLTLVALVLGAAPRLGDMLARQPQILDGLIDPRFFGAMPDQAELSARLAVTLADAGSYEEFLDRLRLFGQESLFLIGTRILSGTVPTQQAAVAFADVAEGIVGTVHGLVSEQFASTYGRVKGQQTAILAMGKLGSREMTASSDLDLILIYDFDDDQPDSDGERSLHGAQYFARFTQRLISAFTTRTNYGVLYDVDMRLRPSGRAGPVASRLDAFAAYQEQEAWTWEHLALTRARVISAPPEFRSRIEQVIRAVLTRQRDAAIIANDVAEMRRAIAQEKGEDDVWDLKYAAGGMVDIDFIAQYLQLVHAHEAPDILHVNTLSALDNATRLGLLAQADAEVLRPAARLYQNLTQILRLCVSEKFNPDTAGDDLLRVMVRAGDAPDFSSLQARVKETQSDVRAIFSRLIGGEDA

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

990 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

109.385 kDa

MIFSAITADLDNTALAARFGAGPRLYDPVLAAERWAGWLVDLAPEQADAIAALGNAFPDLQIALQSIAEASPYLFDLIRGDPVRLLRVLRGAPEQRLAKLLEDAETFVAAASAEDEVMAALRRLKAEAALLIALCDIGGIWPVMQVTQALTDLAGRSVQMALRFLLRLEAGRGRIVPPNPDCPEQGSGLIVLAMGKMGAGELNYSSDIDLIVFYELDAPTLAPDIEPQPFFVRVTQGLSRILQQRRGDGYVFRVDLRLRPDPASTPVALSTVSALDYYEREGRTWERAAMIKARPCAGDLVAGDALLSEIAPFVWRKHLDFAALSDVHDMKRQMQTYRGQTEIAVEGHNVKVGRGGIREIEFFAQTQQLIAGGRHPELRVRPTLEALEILAARNWITIQARDELTEAYLFLRKVEHRVQMIADEQTHALPDTVEAIERFSRFLGYDSRDSFARDLLGYLERVQGHYAKLFEGDPTGTAKLPPVDYGAGPEDTRLLDHLLSLGYKKPLMIATTLQQWMTGGYRVLKVETTQRAFREFVPALIEELARAEQPDDAVNAFDRLLQALHRGGRLISLLSQNRELLTLVALVLGAAPRLGDMLARQPQILDGLIDPRFFGAMPDQAELSARLAVTLADAGSYEEFLDRLRLFGQESLFLIGTRILSGTVPTQQAAVAFADVAEGIVGTVHGLVSEQFASTYGRVKGQQTAILAMGKLGSREMTASSDLDLILIYDFDDDQPDSDGERSLHGAQYFARFTQRLISAFTTRTNYGVLYDVDMRLRPSGRAGPVASRLDAFAAYQEQEAWTWEHLALTRARVISAPPEFRSRIEQVIRAVLTRPRDAAIIANDVAEMRRAIAQEKGEDDVWDLKYAAGGMVDIDFIAQYLQLVHAHEAPDILHVNTLSALDNATRLGLLAQADAEVLRPAARLYQNLTQILRLCVSEKFNPDTAGDDLLRVMVRAGDAPDFSSLQARVKETQSDVRAIFNRLIGGEDA

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

989 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.894 kDa

MNSSAIDADIPPSALAARFAAGPQLHAPEEAEKRLADWLGDVPADLAGAIRSVADRHPHVGVALRSIAEASPYLFDLIRADPARLLGLLRSDPEAGFVALLDRASAAVAAASDEAEVMAVLRKMKAEAALSIALCDIGGLWPVMQVTQALTDLAVNSVQMTLRFLLRQEAARGRIIPPNSDAPEQGSGLVVLAMGKMGAGELNYSSDIDLIVFYDLDAPTLAPDIEPQPFFVRVTQGLSRILQQRRHDGYVFRVDLRLRPDPASTPVALSTVSALNYYEREGRTWERAAMIKARACAGDLVAGEALLGDIAPFVWRKHLDFAALSDVHDMKRQMQTFRGQTEVAVEGHNVKVGRGGIREIEFFAQTQQLIAGGRHPELRVRPTLAALDILAARDWITYQARDELSVAYQFLRRVEHRIQMIADEQTHTLPDSVEAVERFSRFFGYESREAFARDLLAYFDCVQGHYGKLFEGDPTGTVKLPIDYAGGPDDTGLLDHLHGLGYKKPLMVATTLQQWMTGGYRILKVETTQRAFHEFVPMLIEELARAEEPDNAVNAFDRLLQALHRGGRLISLLSQNRDLLTLVALVLGAAPRLGDMLARQPQILDGLIDPRFFGAMPDRAELSARLAATLADAGPYEEFLDRLRLFGQESLFLIGTRILSGTVSTQQASVAFADVAEGIVGTVHDLVSEQFISQYGRIKDQQTAILAMGKLGSREMTASSDLDLILIYDFDHEQPDSDGERSLQGAQYFARFTQRLISAFTTRTNYGVLYDVDMRLRPSGRAGPLASRLDSFAEYQEVEAWTWEHLALTRARVISASPEFRERIEQVIRAVLTRPRDAAIIANDVAEMRHAIAQEKGEDDVWDMKYAAGGMVDIDFIAQYLQLVHAAATPEILGVSTLGAIDNAARLGVLAQSDAEVLRPAARLYHDLTQILRLCVSDKFKPETAGEDLLRVLVRAGDAPDFSSLEARVKETQAEVRAIFNRLIGGDSA

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

989 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

107.062 kDa

MRGPLEPDSADRPSLAILMREAPVLGDAETAEIKLSQATESLSPAERAALDGLLSRAPIARAVCLGMAEGSPFLLDLVRAEPTRLLRVLSDDPHAHLARLMADCAATAASGSEAEVMRALRRMRSEAALLIALADMGGAFDLIAVTAALTDVADAALRAALAFLLGDAARAGRLKPQDAADPAVGCGLAVIAMGKHGARELNYSSDIDLVVVFDREKAPLAEEVSAAPFFVKITQGLVRLLQERTADGYVLRVDLRLRPDPGSTAVALSTAAALDYYEREGATWERAAYIKARPVAGDLAVGRTFLAELSPFVWRRGLDFQAIADVHAMKREIHAFRGHDVVAVEGHNVKLGRGGIREVEFFVQTQQLIAGGRDPLLRNSRTLEALDALTAHRWIEPSVRDALAEAYVFLRRVEHRIQMVADAQTHSLPESRPAMEGFARFMGYPDRDAFAAALVTRLQTVQTHYANLFEDVAPPAVLDADLMFPPDENDRKTLAALSRLGFRDPAAASGMVRRWLSGGPRALKGESARAHLARIVPLMLEALARGGDPDGALAAADRFLSDLPGPQLLTALDRHPDLVRLLATILTAAPRLGETLARRPSLTDALLDPAFFDVLPDEAGLTAHLEHLLDTADTDEEQLDRARRFRQEQHVLIGVRIASGTLEAARAGEAYATLAEVIIRALHRRVWARFREAHGTIAGAQTAVLAMGKLGGREMTAGSDLDLIVLYDFDADADPTSDGARPLTGAQYFARFTQRLVTALTSLTNAGKLYDVDLRLRPSGRSGPVATRLASFATYQREEAWTWEHMALTRARVIAAEPEFGAKVRDVICAVMGQPRDPRRLAGDILDMRQSIAAEKGEGDMWNLKHAAGGQVDVEFLAQYLVLAHACAHPEIVDTATARVLATAARLGLLEPEDAHVLQRACRLYQNLTQVLRLAVDAHIVPADASPALRALLARAGEMPDFTTLDADLADTQAKVRTIFERILETAAE

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

988 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

109.21 kDa

MTKRETVERRLSEVPPGVIRPYTQTELKSVFSTLKDIGKAEPAVAALLAGESPLKDFIAAAFTLSPYLRDMAAADEGLLTLAISKPLEPLLTDLVRDARDCWKPAEDAVPVENEVMSRLRIAKRRLSFVAALADLARIFTARDTTRWLSEMADASLSAAIDHLLLSAHESGKLKLKNLAAPSEGSGLIVLGMGKLGARELNYSSDIDAVVFFEPSAGIIDDPYDATENFGRMMRRLVRIMQERTADGYVFRTDLRLRPDPGSTPLAIPVEAALLYYEGRGQNWERAAYIKARPVAGDIKAGENFLRELTPFIFRKYLDYAAIADIHSIKRQIHAHKGHGAIAVKGHNVKLGRGGIREIEFFAQTQQLIAGGRMPPLRVRATEDALAALTEAKWIDAETRDSLTEAYWFLREVEHRIQMVRDEQTHVLPDTEAELKRIAFMLGFEDTKAFSEKLEEVLRLVERRYSALFEQETKLSGEAGNLVFTGQKDDPDTLKTLSTLGFQRPEDISRVIRTWHNGRYRATQSVEARERLTELTPDLLRAFGESKRADEALLRFDNFLSGLPAGIQLFSLLGNNPALLSLLVTIMSSAPRLAEIIAARPHVFDGMLDPALMSDVPTRDYLAHRMGNFLSNARHYEDILDRLRIFAAEQRFLIGVRLLTGAIRGEVAARAFTHLADLVIEAALNAVLSEMEAAHGPYPGGRVAVMGMGKLGSFELTAGSDVDLILLYDYDDTAQESTGAKPLDVVRYFTRVTQRLIAALSAPTAEGVLYEVDMRLRPSGNKGPVATRISAFEKYQREEAWTWEHMALSRARLICGDASLMEDARSIIASILSQKRDVAKVSTDVLDMRSLIEQEKPPENNWDFKLINGGLIDLEFIAQYLALIGPVKGLGAHEPGRNTAEALQALAAPVMESQAFDDCMAAMGLYTEISQIVRLCIDGAFNPKEAPAGLIDLVCRAGDCPDIPTLEGEVKRLSKAVRKAFVAVVKNGG

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

988 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

109.21 kDa

MTKRETVERRLSEVPPGVIRPYTQTELKSVFSTLKDIGKAEPAVAALLAGESPLKDFIAAAFTLSPYLRDMAAADEGLLTLAISKPLEPLLTDLVRDARDCWKPAEDAVPVENEVMSRLRIAKRRLSFVAALADLARIFTARDTTRWLSEMADASLSAAIDHLLLSAHESGKLKLKNLAAPSEGSGLIVLGMGKLGARELNYSSDIDAVVFFEPSAGIIDDPYDATENFGRMMRRLVRIMQERTADGYVFRTDLRLRPDPGSTPLAIPVEAALLYYEGRGQNWERAAYIKARPVAGDIKAGENFLRELTPFIFRKYLDYAAIADIHSIKRQIHAHKGHGAIAVKGHNVKLGRGGIREIEFFAQTQQLIAGGRMPPLRVRATEDALAALTEAKWIDAETRDSLTEAYWFLREVEHRIQMVRDEQTHVLPDTEAELKRIAFMLGFEDTKAFSEKLEEVLRLVERRYSALFEQETKLSGEAGNLVFTGQKDDPDTLKTLSTLGFQRPEDISRVIRTWHNGRYRATQSVEARERLTELTPDLLRAFGESKRADEALLRFDNFLSGLPAGIQLFSLLGNNPALLSLLVTIMSSAPRLAEIIAARPHVFDGMLDPALMSDVPTRDYLAHRMGNFLSNARHYEDILDRLRIFAAEQRFLIGVRLLTGAIRGEVAARAFTHLADLVIEAALNAVLSEMEAAHGPYPGGRVAVMGMGKLGSFELTAGSDVDLILLYDYDDTAQESTGAKPLDVVRYFTRVTQRLIAALSAPTAEGVLYEVDMRLRPSGNKGPVATRISAFEKYQREEAWTWEHMALSRARLICGDASLMEDARSIIASILSQKRDVAKVSTDVLDMRSLIEQEKPPENNWDFKLINGGLIDLEFIAQYLALIGPVKGLGAHEPGRNTAEALQALAAPVMESQAFDDCMAAMGLYTEISQIVRLCIDGAFNPKEAPAGLIDLVCRAGDCPDIPTLEGEVKRLSKAVRKAFVAVVKNGG

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

988 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.893 kDa

MSSSAIDADISPASLAARFAAGPQLHAPDEAEKRCADWLADVPAELAAPIRAVADRCPNLRIALQSIAEASPYLFDLIRADPARLLRLLRSEPETGFRALLDATAAAVATASDEAEVMAVLRRMKAEAALSIALCDIGGLWPVLQVTQALTDLAVQSVQMTLRFLLRQEAARGRIHPPNPDAPEERSGLIVLAMGKMGAGELNYSSDIDLIVFYELDAPTLAPDIEPQPFFVRVTQGLSRILQQRRHDGYVFRVDLRLRPDPASTPVALSTASALNYYEREGRTWERAAMIKARACAGDVVAGEALLSEIAPFVWRKHLDFAALSDVHDMKRQMQTFRGQTEVAVEGHNVKVGRGGIREIEFFAQTQQLIAGGRHPELRVRPTLAALDILANRDWITFQARDELSAAYQFLRRVEHRIQMIADEQTHTLPDSIEAVERFSRFFGYASREAFARDLLAHLDCVQGHYSKLFEGDPTGTAKLPIDYAGGAEDTVLLDHLRALGYKKPLMVATTLQQWMAGGYRILKVEATQRAFNDFVPALIEELARAEEPDNAVNAFDRLLQALHRGGRLISLLSQNRDLLTLIALVLGAAPRLGDMLARQPQIMDGLIDPRFFGAMPDRTELSARLAATLSDAGSYEEFLDRLRLFGQESLFLIGTRILSGTVSTQQASIAFADVAEGIVGTVHDLVSKQFVSQYGRIKDQETAILAMGKLGSREMTAASDLDLILIYDFDHEQPDSDGERSLHGAQYFARFTQRLISAFTTRTNYGVLYDVDMRLRPSGRAGPLASRLDSFAEYQEVEAWTWEHLALTRARVISASPEFRARIEQVIRAVLTRPRDAAIANDVAEMRAAIAQEKGEGDVWDLKYAAGGMVDIDFIAQYLQLVHAATMPDILAVGTLSAIDNAARLGVLAQPDADVLRPAARLYHDLTQILRLCVSDKFKPETAGDDLLRVLVRAGDAPDFSSLQARVKETQAEVRAIFNRLIGGNGE

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

986 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

109.423 kDa

MTSSAPGNADGQSRLAARFVAGPHVRAPDTAEHRLQDWLAELEPSLAASLRDQFASGWARSILLGIVESSPYLFDLIRADAQRLDRLLRCDPQTHLAELIARTGREVFACSGEADVMSLLRRLKSEAALLIALCDIGGVWPVMQVTAALTDVAVAAVQMALRHLLRQEAARGRLAPIDPAQPELGCGLFVLAMGKMGAGELNYSSDIDLIVFFDPDATTLAHDIEPQPFFVRVTQALARLLQSRTADGYVFRVDLRLRPDPASTQVAMSTEAALHYYEREGRTWERAAMIKARICAGDVAAGEAMLAELSPFVWRKHLDFQALTDVHDMKRQMQVYRGHSEIAVEGHNVKVGRGGIREIEFFAQTQQLIAGGRHPELRVRPTLQALDVLTASNWITAQARDELTSAYEFLRRVEHRLQMMADEQIHSLPDDVDGVARFACFFGYESRERFATDLLFHLDIVQGHYARLFEGDPTGTVSLPPVNYGAGPDEPRLLEHLVALGFRDPMMVALTLQQWLAGDYRVFRAEATRTTFNEFLPALIDGLAHADEPDRAVVAFDRFLQALQLGGRLITLLGQNRDLVALVALVLGAAPRLGDMLARQPRLMDGLIDPRFFGAIPDKRELSTRLAATLQDAGSYEEFLDRLRLFGQESLFLIGTRILSGTVSAQQAGTAFADVAEGIVHTVHNLVIERFAAQHGRIRGQETAIIAMGRLGAREMTASSDLDLILLYDFDADAPDSDGERPLQGAHYFARFTQRLISAFTSRTNYGVLYDIDMRLRPSGRAGPLASHIDSFAHYQEHEAWTWEHMALTRARVISASPAFRARIEAIIQTALRRSRDAQAIARDVADMRRAIAAEKGETDLWDLKHAAGGMVDIDFVAQYLQLVHAASKPEILDISSLQVLDHAERLGVLPRADAVILRHAARMYHDLTQILRLCVSDKFKPDQAGDDLLRVMTRAGDAPDFSALEARVRETQSEVRRVFTALLER

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

986 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

106.531 kDa

MVTTVISNVKRQSRASLVGKRNAGHRSAMSKLADRLAPCGPVLDPKAAERAYEAIAKRAGEAMGQVDAAWGSLAPVFAASPYLAGLARRDGKRLPRILGGDPGETLAAILAAAEAVAAEPDFETARRVLRELKADLHLLTAISDLGGVWDLDQVTGALTRFADAVLHAALAQAVRQEVSRGALTHVGDGSAGPAPGLFCVAMGKHGAFELNYSSDIDFSIFYAPEKLPVAEGHEPQAVAVRIANHLGRILQERTGDGYVFRIDLRLRPDPSSTPPAMPVDAAMDYYESVGQNWERAAHIKARIAAGDAAEGAAFLEGLQPFIWRRNLDFAAIADIHSIKRQIHTYKVDDRLTAKGADLKLGRGGIREIEFFVQTQQLILGGRQPDLRSPRTLDALQALAAAGHVTPEDAAWLTQAYKDLRALEHRAQMIADDQTHKLPESDVERKKVAALWGEGNLRVFDAAVGKMLKGVNLRYGRLFAGEEALSSRFGSLVFTGVEDDPETLATLKRMGFSSPERVAATIRGWHHGHIAATRTERGRELFTRLAPRLLDAANATGAPDQAFNRFSDFFSRLSSGVQIQSLFLAQPRLFELIVEVMAFAPRLAATMAKRPTALDALLDPTFFGPIETPAIAPWDPEDFEGAMDAARRLFRDQSFRIGVRVMSGTADARDIGRAFAELADLIIGGLAPAALAEVERIGGAFPGQVAVVALGKAGSREMTAKSDLDLMTLYVADDPRSMSALKDWSAEVFYARLTQRLTSALSAPTGEGTLYEVDLKLRPSGTKGPVAVSFAAFEHYYEREAETWELLALTRARVVWASSPDFKARAEGAIAAALRRPRAWKKTAADVIEMRQLMERERPGKGDWDLKLDPGGLVDIEFAAQFLQLAHAAADGPLRQNTGEALAALREAGLADAGALSRLEAAWRLEQDLSQLIKVALEDGADVEVEPKAFKALLAKAGGVTQFKSLKPKLAKAKAEARAAYEAVVKG

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

986 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

107.857 kDa

MAAVAKRTVTDWQLKPALGLAPLDQGRARQELAEIAAAAREEGLARLAKFLAGKGAGQDFLAAVFDLSPFLRDTSRRRPRILDALFDQPVEARLEAITAAIEQAPLAETVSESSLMMELRQCKAEAHFLIALADLAGEAETSLTVRRLSDLADACTRAAVDFLLRDAHGQGKLKLPDLDNPSLQSGWILLGMGKLGAHELNFSSDIDLVVFFDPDAPAVVDRLDATELFSRLTRRLVRILQDRTEHGYVFRTDLRLRPDPGSTPLAIPVEAALRYYEARGQNWERAAMIKARPVAGDLAAGAAFLRELQPYIWRKYMDYAAIADVHSIKRQIHAHKGHGEIAVKGHNVKLGRGGIREIEFFVQTQQLIAGGRFPELRGRETVPMLGQLAARGWITADARDALARQYWFLRRVEHAVQMVADEQTHTLPEDDEGLERIAHMLGFGDAAAFSQAFRASLLQVERHYAALFETAPELSAGIGNLVFTGDVDDPNTLQTLQGLGFQRPSDICRVIRGWHFGRYRVTQSAEARERLTELTPALLKAFGQTRRADEALIRFDEFLAGLPAGIQLFSLLQSNPALLKLMATIMGAAPRLAAIITRRPHVFDGLLDPALLTELPDRVYLSARLSAFLEGDRAYEEVLDRLRIFASEQKFLIGVRLLAGSIDPARAGRAFSDLADLTIEAALQAVTAEFAARHGTIAGGVVSLLGMGKLGSRELTAGSDVDLILLYDHDADAEDSDGDKPLAPSHYYTRMTQRLISAVSAPTAEGVLYELDLRLRPSGNKGPVATHIDAFKKYQRQEAWTWEHMALSRARAIGGDTGLCAEVEAEVAAVLGQPRDAAKVKTEAADMRAMIEKEKPARDLWDIKLIPGGLIDLEFIAQVAVITGQVGAGPRATGTAEILSRLAPGFADAGARQELGAAFALYLALTQMTRLCLTGSFERDDVPPGLSDLLLAVTDLPDFGVLEAHLKETSQKVRKDFDLLLRAGRP

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

986 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.47 kDa

MAEAIERSLSDIDVVAIRPASQADAKAALSVLKDAAKGSDHIAKLIASDAPLKDFLVAAFALSPFLRDTARSHPAILEALLSETLPAFLKRRIEAARVAWRGDAAGAALPDAEIMTRLRRAKREVAFAVALADLSRLFGGRETTGWLSDFAEAAVSAAIDHLLLGAHESGKFVLKDSSAPSTASGVVVLGMGKLGAGELNYSSDIDLVVFYDPQSSIITNRDDAPETFARLLRRLIRILQERTGDGYVFRTDLRLRPDPGSTPLAIPVEAAMLYYESRGQNWERAAFIKARPIAGDLEAGERFLKELTPFVFRKYLDYAAIADIHSIKRQIHAHKGHGEIAVKGHNIKLGRGGIREIEFFVQTQQLIAGGRTPALRLRQTETMLRMLAESGWIDGATAEELIEAYWFLRDVEHRIQMVHDEQTHLLPETEPELRRIAYMLGFEDTASFSNALSRVLRTVERRYAQLFEQEAKLSTETGNLVFTGQQDDPDTLETLKKLGFQRPSDIANIIRTWHYGRYRATQSVEARERLTELTPELLRVFGESRRADEAFLRFDHFLSGLPAGIQLFSLLGNNPGLLSLIVNIMSSAPRLADIIAAKPHVFDGMLEPGLLAELPTRDYLAPRIATFVGGGRHYEEVLDRLRIIAAEQRFLIGIRLLTGAITGLQAGRALTDLADLIIAAALDAVLEEVRSAHGRFPGGRVAIVGMGKLGSHELTAGSDIDLILLYDYDDEVLESDGAKPLDPVRYFTRVTQRLIAALSAPTAEGILYDVDMRLRPSGNKGPVATRITAFAKYQRTEAWTWEHLALTRARCICGDESLVGEAEAIFAEILTEKRDIAKIRKDVEEMRGLIDKEKPPKDIWDFKLIPGGLVDIEFIAQYLALVAPARGVTSPPAGTHTLEALKALGAGMMNANDLDTAAEALVLFTELSQLVRLCIDGDFDPKEAPAGLVDLVCRAGDYPDLTHLEADIRRLSKAVRRIFQGVVAAA

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

986 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

113.973 kDa

MSFPLAHVDATLNQLAKQLIAHFPEQYQDQIFQHIATDKEKPTSNIGQLRYAIAMSDFFAETLQKQPHFLHQCWQQCPRLQDCEQYAERLTPLLAQVENEEQLYKVLRQFRHREMAKLSFCQSLNLGSVEDIFIRLSQLAESVIIGARDWLYQRACAEMGTPVDEQGTPLQLYILGMGKLGGFELNFSSDIDLIFTYASNGETVGARRSIDNAKFFTRLGQRLINALDQYTCDGFVYRTDMRLRPFGENGALALSFAAMELYYQEQGRDWERYAMIKGRILGANAQDPHVNTLQQLLRPFVYRRYIDFSVLQALRDMKHKIEREVRRRGLVDNIKLGAGGIREIEFIVQVFQLIRGGRESALQQPALLKVLPEISALELISAQQQEDLRQAYLFLRRTENILQAIHDQQTQQLPENTLDQQRLVLATQRFTQWDTQNKLETVTYPIHDWASFCEVLQQHQQNVRTVFDHLIGEEKEELSETETLWHDFLENEIEESEIEQMLIEHHIEERDFHEIIEKLMQFRNEVTRRPIGTRGRIALTQVMPTLLPQIFAHTAYLHLLPRMLNIVDKILTRTTYLELLVENPQALTQLIELCAQSRMIAEQVARHPILLDELLDRNALLNPPPYDHYASELRQYLLRLTPDDEEQMIDGLRQFKQATLLRIAAADILGALPVMKVSDHLTFLAEAIIHVVVELAWQQVTTRFGTPAHLAEGEKGFLVIGYGKLGGIELGYKSDLDLVFLYQSDEQSQTCGGKRSIESNQFYLRLAQKIISIFSINTFAGVLYEVDMRLRPSGESGLLCSSISAFKAYQLHDAWTWEKQALVRSRAIYGEARLQTEFNAIRAEVLSAPRDLATLQQDVVAMRQKMYAHLAHPDSDTFNIKTDRGGITDIEFIAQYLVLAHAPQNPALTRWSDNVRIFEIMAESAVISQEICDQLKQCYVDLRNRIHHLNLLGELSIVPQTEFQTERQFIQTIWHRLFEHNDKYEE

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

985 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

109.59 kDa

MTSSAPGNADGQILAERFVSGPHVRAPDKAEHRLNEWLAELEPSLAASLRALLAKGLPRSILLGIAECSPYLFDLVRADARRFERLLRSEPQAHLAELISRTGREVFAATSEADVMRLLRQLKSEAALLIALCDIGGVWPVMQVTAALTDVAVSAVQMALRYLLRQEAVRGRLAPRDADDPEQGCGLFVLAMGKMGAGELNYSSDIDLIVFFDPEVHSLARDIEPQPFFVRVTQALARLLQSRTADGYVFRVDLRLRPDPASTQVAMSTEAALHYYEREGRTWERAAMIKARICAGDVAAGEAMLAELSPFVWRKHLDFQALTDVHDMKRQMQVYRGHSEIAVEGHNVKVGRGGIREIEFFAQTQQLIAGGRHPELRVRPTLQALGVLTASKWITEQARDELTTAYEFLRRVEHRLQMMADEQIHSLPDDAEGVSRFACFFGYESRERFASDLLFHLNIVQGHYARLFEGDPTGTVSLPPVNYGAGPDEPRLMEHLAGLGFRDPVMVAKTLQQWLAGEYRVFRTEATRTSFTEFLPALIDGLAHADEPDRAVVAFDRFLQALQLGGRLISLLGQNRDLVALVALVLGAAPRLGDMLARQPRLMDGLIDPRFFGAMPDKRELSQRLAATLQDAGTYEEFLDRLRLFGQESLFLIGTRILSGTVSAQQAGTAFADVAEGIVHTVHGLVTERFAAQHGRIKGQETAIIAMGRLGAREMTASSDLDLILLYDFDADEPDSDGERSLQGAHYFARFTQRLISAFTSRTNYGVLYDIDMRLRPSGRAGPLASHLDSFAHYQEREAWTWEHMALTRARVISASPAFRARIEEIIQTALRRPRDPVAIARDVADMRRAIAAEKGEADLWDLKHAAGGMVDIDFVAQYLQLVHAATKPEILDVSSLQVLDHAERLGVLPRADAVILRHAARLYHDLTQILRLCVSDKFKPDQAGEDLLRVLARAGDAPDFSALEARLRETQSEVRRVFTSLLEE

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

985 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

109.59 kDa

MTSSAPGNADGQILAERFVSGPHVRAPDKAEHRLNEWLAELEPSLAASLRALLAKGLPRSILLGIAECSPYLFDLVRADARRFERLLRSEPQAHLAELISRTGREVFAATSEADVMRLLRQLKSEAALLIALCDIGGVWPVMQVTAALTDVAVSAVQMALRYLLRQEAVRGRLAPRDADDPEQGCGLFVLAMGKMGAGELNYSSDIDLIVFFDPEVHSLARDIEPQPFFVRVTQALARLLQSRTADGYVFRVDLRLRPDPASTQVAMSTEAALHYYEREGRTWERAAMIKARICAGDVAAGEAMLAELSPFVWRKHLDFQALTDVHDMKRQMQVYRGHSEIAVEGHNVKVGRGGIREIEFFAQTQQLIAGGRHPELRVRPTLQALGVLTASKWITEQARDELTTAYEFLRRVEHRLQMMADEQIHSLPDDAEGVSRFACFFGYESRERFASDLLFHLNIVQGHYARLFEGDPTGTVSLPPVNYGAGPDEPRLMEHLAGLGFRDPVMVAKTLQQWLAGEYRVFRTEATRTSFTEFLPALIDGLAHADEPDRAVVAFDRFLQALQLGGRLISLLGQNRDLVALVALVLGAAPRLGDMLARQPRLMDGLIDPRFFGAMPDKRELSQRLAATLQDAGTYEEFLDRLRLFGQESLFLIGTRILSGTVSAQQAGTAFADVAEGIVHTVHGLVTERFAAQHGRIKGQETAIIAMGRLGAREMTASSDLDLILLYDFDADEPDSDGERSLQGAHYFARFTQRLISAFTSRTNYGVLYDIDMRLRPSGRAGPLASHLDSFAHYQEREAWTWEHMALTRARVISASPAFRARIEEIIQTALRRPRDPVAIARDVADMRRAIAAEKGEADLWDLKHAAGGMVDIDFVAQYLQLVHAATKPEILDVSSLQVLDHAERLGVLPRADAVILRHAARLYHDLTQILRLCVSDKFKPDQAGEDLLRVLARAGDAPDFSALEARLRETQSEVRRVFTSLLEE

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

985 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

110.626 kDa

MSLPSLADFPAILLPFITRARQTWRTALTELSAEALASFEAWPEARRTAFDRVCAASDFVTEQICRDPQMLLQLAGSGELERSFSVGELRGQIADALSSAVTEDELGRNLRRQRARQQVRIIWRDLTRQADLIETCRDLSEMADASIDLAYQWLYPRHCQQFGTPTGRHCGLPQQMVILGMGKLGAVELNLSSDIDLIFAYPEGGETVGTKRALDNQEFFIRLGQRLIKALDPVTVDGFVFRVDMRLRPYGSSGALVLSFNALEQYYQDQGRDWERYAMIKARVVGGDLAAGAELLEMLRPFVYRRYLDFSAIEALRTMKQLIQQEVKRKGMAENIKLGAGGIREVEFIAQAFQLIHGGRDLSLQQRPLFNVLKTLEGQGYLPSAVTEELREGYEFLRYTEHAIQAIADRQTQMLPDNEQDQARIALIMGFADWASFHERLMYWRSRVSWHFRQVIADPDSDPDDELQDDSEVVVGGEWLPLWEESQDEDAAGRQLLQAGFVDTGKALKSLADLRSSPNLRSMQRLSRERLDAFIPRLLAQAVEHEKPDLVLERVLPLVEAVARRSAYLVLLTENPDALRQLLTLCAASPWIAEQIARFPLLLDELLNEGRLFNPPLAPELAAELRERLVRIPEDDLEQQMEALRHFKLAHSLRVAASEISGSLPLMKVSDYLTWLAEAILDQVLALAWRYSVARHGTPSRPDGTLCDPGFVIVGYGKVGGIELGHGSDLDLVFIHDGDLQTETDGAKPIDSAQFFTRLGQRVIHLLTTQTNSGQLYDVDMRLRPSGASGLLVSSLGAFARYQANEAWTWEHQALVRARVLTGSRDVGEQFEKVRADVLGRERDLDTLRAEVSEMRAKMRDNLGTRLTAAGRAANAFEASVPFDLKQDAGGIVDIEFMVQYAALAWSREHPALLQHTDNIRILEGLEEAGLLPDVDASLLREAYKAYRSAAHRQALQKQAGVVGGDQFHAQRREVMRIWAQMGLS

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

983 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

109.444 kDa

MTVENAKALFFERNLCALTPLDPERASAFLADLEARAREEELAGVVALLGRKKAADFLSAILDLSPFIREALTRQPRILDRIVSATPESALEAILDEISASGTVAGVSESELMTSLRQLKREAHVLIALCDLARIFNTETTTDRLTDLAEACTGAAVRFLLLDADAAGRINLPDRSNPEKDCGWIVLGMGKFGARELNYSSDIDLIVFIDETKPAIGDPYECVDTFSRLTRRLVRILQDRTGDGYVFRVDLRLRPDPGSTPLAIPVGAALHYYEGRGQNWERAAMIKARPVAGDRLSGKQILAELSPYVWRKYLDYAAIADVHSIKRQIHAHKGHGDIAVRGHNVKLGRGGIREIEFFVQTQQLIAGGRFPELRGNQTVPMLARLAERGWITQQARDALAQEYWFLRDVEHRIQMIADEQTHILPEDDEGFARVSHMMGYADPAEFSEIFLAALKVVEKQYAALFEQAPELGAASGNLVFTGDVDDPGTLETLSAMGYERSSDICRVIRTWHFGRYRATQSAEARERLTELTPALLKAFAETRRADESLLRFDGFLQGLPAGIQLFSLLQSNPRLLNLLVMIMSAAPRLADIITRNPHVFDGLLDPAIFSEVPTRAYLEERLRAFLGSATDFEEVLDRLRIFAAEHRFLIGIRLLTGAINGVRAGQAFSDLAELMVGRALEAVEAELQRRHGKVKGAKVALLAMGKLGSRELTAGSDVDLILLYDHDKDAEESDGEKPLAPSKYYIRLTQRLIAALSAPTAEGVLYEVDMRLRPSGNKGPVATHIEAFGKYQRNDAWTWEHMALTRARPIHGDEAFIARIKVDIEDVLAMPRDVRKLAGDVREMRELIAQEKPPRDDWDLKLKPGGIIDLEFIAQFATLAGYVKKTPRPFATEEVLANLDPFFADPAMVDGLVEAHRFYTNLSQAIRLCLNDSAGLDQFPPGMRELLCRVAGLPDIERIEYELLEHYRLVRAAFDKLVGHGAD

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

983 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

109.457 kDa

MTVENAKALFFERNLCALTPLDPERASAFLADLEARAREEELAGVVALLGRKKAADFLSAILDLSPFIREALTRQPRILDRIVSATPESALEAILDEISASGTVAGVSESELMTSLRQLKREAHVLIALCDLARIFNTETTTDRLTDLAEACTGAAVRFLLLDADAAGRINLPDRSNPEKDCGWIVLGMGKFGARELNYSSDIDLIVFIDETKPAIGDPYECVDTFSRLTRRLVRILQDRTGDGYVFRVDLRLRPDPGSTPLAIPVGAALHYYEGRGQNWERAAMIKARPVAGDRLSGKQILAELSPYVWRKYLDYAAIADVHSIKRQIHAHKGHGDIAVRGHNVKLGRGGIREIEFFVQTQQLIAGGRFPELRGNQTVPMLARLAERGWITQQARDALAQEYWFLRDVEHRIQMIVDEQTHILPEDDEGFARVSHMMGYADPAEFSEIFLAALKVVEKQYAALFAQAPELGAASGNLVFTGDVDDPGTLETLSAMGYERSSDICRVIRTWHFGRYRATQSAEARERLTELTPALLKAFAETRRADESLRRFDGFLQGLPAGIQLFSLLQSNPRLLNLLVMIMSAAPRLADIITRNPHVFDGLLDPAIFSEVPTRAYLEERLRAFLGSATDFEEVLDRLRIFAAEHRFLIGIRLLTGAINGVRAGQAFSDLAELMVGRALEAVEAELQRRHGKVKGAKVALLAMGKLGSRELTAGSDVDLILLYDHDKDAEESDGEKPLAPSQYYIRLTQRLIAALSAPTAEGVLYEVDMRLRPSGNKGPVATHIEAFGKYQRNDAWTWEHMALTRARPIHGDEAFIARIKVDIEDVLAMPRDVRKLAGDVREMRELIAQEKPPRDDWDLKLKPGGIIDLEFIAQFATLAGYVKKTPRPFATEEVLANLDPFFADPAMVDGLVEAHRFYTNLSQAIRLCLNDSAGLDQFPPGMRELLCRVAGLPDIERIEYELLEHYRLVRAAFDKLVGHGAD

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

983 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

107.099 kDa

MDRKSSVTIDLLRLGVMDTDAASANHHRIAENIGADPNRLADWEHHLETCCDPDLALNVLAELAQDSAQCLGEVLDHDASACRLVRLLGASSELGRHLIAHPDDLAEVIRDPVRLGHDEICDDLLEVVGAHKEGEFTVAGTPTGPASDRLRLANRRHLVRIASRDVSADDPTEIIEDVAAELADLADGIVTAALALARADCPDHADARLAIIAMGKCGAQELNYISDVDVMYVAEPANDDVSGASAVTIATKLAASVARMCSAHSGAGSIWQVDAALRPEGNAGPLVRTMDSMRTYYEKWAKNWEFQALLKARPMAGDLDLGQRFVEMVSPMVWQVGEAEGFVPETRAMRTRVVSLIAAKNKGREIKLGAGGLRDVEFTAQLLQLVHGRQDESLRVRATLPALRALAAGGYISRGAAERLKEAYRLERVMEHRVQMFRLRRTHLLPDDEDGLRRLARAVGLRTADEVRRVWTATSKAVLRAHGQVFYSPVVEAVARIPTQDLRMSAEAAKVRLSALGFHDEDAGLRHIEALTSGTSRAVRIQTALMPAMLAWLADGPSPDHGLLAFRQVSEALGESPWYLRALRDEGAMAQRLAVVLSTSRYAVDVLTRAPETVQVLVDDDLTPLSREDLARQMNAVARRHHDVEEAVGAIRAVRRRKLFRILVADILNVTGIRRIGQALTDLTGATIDAALTAVSREVEDAPPIGIVAMGRWGGQELSYASDADCLFVVGDGPGVGEKALKIVTKLRNLLGKHGADPAVVLDADLRPEGRSGPMVRSLESYRKYYGKWSSTWESQALLRASHGAGDRELTNELLEYVDQVRYPADGLTGSQLAEIRKLKARMESERIPRGVDPRRHLKLGPGGLSDIEWTAQIIQLQHAGHDPALRTTSTIDALNAALAAGYIDEGQHAKLCDSWLAASRLRNAIMVVRGRPSDVIPSDSTDLDVIAKASGMGQGASEHLVEDHLRHCRRASRVVDAVFWNQ

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

982 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

110.104 kDa

MSLPSLANLPATLLPAAERAGTALRSAVAALDAAALARLEAWPEERLEDFRRVAAASDFVAEQAVRDSAMLLELAERGELENPHAPGELRSQLQARLEDCADEDELGRRLRRFRTRQQLRIIWRDLTRRAALAETCRDLSALADACIDLACEWLHRRQCEQFGTPIGRRSGEPQRMVVLGMGKLGAVELNLSSDIDLIFGYPEGGETEGAKRSLDNQEFFTRLGQKLIKALDAITVDGFVFRVDMRLRPYGSSGPLVYSFAALEQYYQDQGRDWERYAMIKARVVGGDQQAGEQLLGMLRPFVYRRYLDFSAIEALRTMKQLIQQEVRRKGMSENIKLGEGGIREVEFIAQAFQLIHGGRDLSLQQRPLLKVLATLEGQGYLPPAVVEELRGGYEFLRYAEHAIQALADRQTQMLPSDEYDRIRVAFIMGFASWAAFHERLSHWRARIDWHFRQVIADPDEDESGEAACGSVGAEWIPLWEEALDEESASRQLADAGFVDAEAAWKRLSDLRHGPQVRAMQRLGRERLDAFVPRLLAMTVENPQPDLVLERVLPLVEAVARRSAYLVLLTENPGALERLLTLCAASPMVAEQIARFPILLDELLNEGRLFRPPQAAELAAELRERLMRIPEDDLEQQMETLRHFKLAHGLRVAASEIAGTLPLMKVSDYLTWLAEAILVEVLELAWRQLVQRHGRPLRADGTPCDPDFVIVGYGKVGGLEFGHGSDLDLVFIHDGDPQCETDGGKSIDGAQFFTRLGQKIIHFLTAQTPSGTLYEVDMRLRPSGAAGLLVSSLGAFQRYQEQEAWTWEHQALVRARVLAGCRRVQASFEAVRAEVLARPRDLDALRTEVSEMRAKMRDNLGTRATAAGTASNAFEATAAFDLKHDAGGIVDIEFMVQYAVLAWSGEHPALLEFTDNIRILEGLERAGLIASEDVRLLQEAYKAYRAAAHRLALQKEAGVVSGEHFQTERREVIRIWRELRLG

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

981 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

112.759 kDa

MTALSALIEQKLQSLGTILCQSFPELSPEKIHEAIQQNSNHPELPVYQLGYAIAMSDFVEKVLQKYPHLVKQWWEKSPCFADCTAYIERLNKELANVHDETALYQTLRQFRNIEMAKLSFCQSLNLATVEEIFVQLSQLAESLIIAARDWLYHQACAEIGTPMDEQGNPQQLYILGMGKLGGFELNFSSDIDLIFTYPSQGETSVENTNARRSVDNGKFFTRLGQRLISALDEFTSDGFVYRTDMRLRPFGDSGVLVLSFSAMEQYYQDQGRDWERYAMIKGRVLGAQTKDPNVSKLKKMLRPFVYRRYIDFSVIQSLREMKGKIEREVRRRGLKDNIKLGAGGIREVEFIVQVFQLIRGGREINLQQHSLLKILPEITKLRLITEQQFHDLRESYIFLRRVENILQAINDQQTQTLPTDEIDQIRLVEACKTFTCLNENNQTIEKHYPIENWDDFYRTLQQKQEKVRAVFTQLIGDEQDESSQTDSQWQDFLEADFEDIEQTLLESSVSENNIDEVLEKLAQFKDGLNHRVIGSRGRDVLSHLMPTVLALIFEQENYRTLLPRILNIIEKISSRTTYLELLLENPRALQQVIELCAQSQLISEQLAHYPILLDELLNTEALRHPLPFTQYPAELHQYLLRLPPDDEEQLIDALRQFKQATLLKVAAADILGALPVMKVSDHLTYLAEAIIEVVVNLAWKQVSSRFGVPEHLQNNEKGFLVIGYGKLGGIELGYKSDLDLVFLYDAVESQTTGGKKVIDSNQFYLRLAQKIVSIFSINTSAGVLYEADMRLRPSGDAGLIGCSLSAFSHYQLNDAWTWEKQALVRARPVFGESSLKAKFEHIRQQVLSASRDIEQLKQDVVEMRKKMFAHLSHSKHSEFNLKTDRGGITDIEFIAQYLMLANAPKKPQLTKWSDNVRIFDDMAEAKIISQTDCDTLKQCYVDLRNTIHHLNLLGKSSVVEDSEFVKERSFIQAFWDRLFVS

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

981 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

113.008 kDa

MTMPLPSIEQTLIQLADNLITHFPEQFNSQIYQQIQKDISNIKTPVGALMRAVSMSDFVTEILQKQPHFLAECWHKTPQLADCDSYAARLSVQLADIREETGLYKTLRDFRNQEMAKLSICQSLNSATVEEIFIRLSQLAEALIIGARDWLYQRACLDWGTPTDNQGNVQQLYILGMGKLGGFELNFSSDIDLIFTYPANGETVGSRKPIDNQKFFTRLGQRLISALDEFTEDGFVYRTDMRLRPFGDSGALALSFNAMESYYQEQGRDWERYAMIKGRILGADEQDPNVKTLRQLLRPFIYRRYIDFSVIQSLRDMKSKIEREVLRRGLVDNIKLGAGGIREIEFIVQVFQLIRGGREISLQQHELLKLLPEIEKLNLITADQHQDLLQAYLFLRRVENVLQAINDKQTQLLPADELNRCRLISATCEFTQWDNNHRPQKIQYPIHDWESFYQVLQQHQQKVRSVFNNLIGFNNENEADDSDNAWSDFLDADLEQGEIADILAQQGVSEEERDEIIGRLEAFRHSVSHRSIGIRGREVLTQLMPLLLLQIFSNKKYRTLLPRMLNIVEKILTRTTYLELLLENPQALTQLIELCAKSQLIAEQVAQHPILLDELLDREALLNPPSFEQYPAELQQYLLRLPEDDDEQFITALRQFKQATLLRIAAADILGALPVMKVSDHLTFLAETILHTVVNLAWQQITARFGKPEHLQNNEKGFLVAGYGKLGGIELGYRSDLDLVFLCDEIHSGQTVGGKKVIDSHQFYLRLAQKIISIFSMTTSAGILYEVDLRLRPSGEAGPLCCSFKAFEDYQMNEAWTWEKQSLVRSRAVYGEPALREKFELIRTGILASPRDLTQLKIDVREMREKMYRHFAGADDNKFNIKKDQGGITDIEFIAQYLVLAHAPENPNLAYWSDNVRIFDIMAEHGIITLNEAEKLKNCYTGLRNQIHHLNLLGEPPIVSKEEFADERRFIHQIWQKLFFE

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

981 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

112.759 kDa

MTALSALIEQKLQSLGTILCQSFPELSPEKIHEAIQQNSNHPELPVYQLGYAIAMSDFVEKVLQKYPHLVKQWWEKSPCFADCTAYIERLNKELANVHDETALYQTLRQFRNIEMAKLSFCQSLNLATVEEIFVQLSQLAESLIIAARDWLYHQACAEIGTPMDEQGNPQQLYILGMGKLGGFELNFSSDIDLIFTYPSQGETSVENTNARRSVDNGKFFTRLGQRLISALDEFTSDGFVYRTDMRLRPFGDSGVLVLSFSAMEQYYQDQGRDWERYAMIKGRVLGAQTKDPNVSKLKKMLRPFVYRRYIDFSVIQSLREMKGKIEREVRRRGLKDNIKLGAGGIREVEFIVQVFQLIRGGREINLQQHSLLKILPEITKLRLITEQQFHDLRESYIFLRRVENILQAINDQQTQTLPTDEIDQIRLVEACKTFTCLNENNQTIEKHYPIENWDDFYRTLQQKQEKVRAVFTQLIGDEQDESSQTDSQWQDFLEADFEDIEQTLLESSVSENNIDEVLEKLAQFKDGLNHRVIGSRGRDVLSHLMPTVLALIFEQENYRTLLPRILNIIEKISSRTTYLELLLENPRALQQVIELCAQSQLISEQLAHYPILLDELLNTEALRHPLPFTQYPAELHQYLLRLPPDDEEQLIDALRQFKQATLLKVAAADILGALPVMKVSDHLTYLAEAIIEVVVNLAWKQVSSRFGVPEHLQNNEKGFLVIGYGKLGGIELGYKSDLDLVFLYDAVESQTTGGKKVIDSNQFYLRLAQKIVSIFSINTSAGVLYEADMRLRPSGDAGLIGCSLSAFSHYQLNDAWTWEKQALVRARPVFGESSLKAKFEHIRQQVLSASRDIEQLKQDVVEMRKKMFAHLSHSKHSEFNLKTDRGGITDIEFIAQYLMLANAPKKPQLTKWSDNVRIFDDMAEAKIISQTDCDTLKQCYVDLRNTIHHLNLLGKSSVVEDSEFVKERSFIQAFWDRLFVS

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

981 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

113.008 kDa

MTMPLPSIEQTLIQLADNLITHFPEQFNSQIYQQIQKDISNIKTPVGALMRAVSMSDFVTEILQKQPHFLAECWHKTPQLADCDSYAARLSVQLADIREETGLYKTLRDFRNQEMAKLSICQSLNSATVEEIFIRLSQLAEALIIGARDWLYQRACLDWGTPTDNQGNVQQLYILGMGKLGGFELNFSSDIDLIFTYPANGETVGSRKPIDNQKFFTRLGQRLISALDEFTEDGFVYRTDMRLRPFGDSGALALSFNAMESYYQEQGRDWERYAMIKGRILGADEQDPNVKTLRQLLRPFIYRRYIDFSVIQSLRDMKSKIEREVLRRGLVDNIKLGAGGIREIEFIVQVFQLIRGGREISLQQHELLKLLPEIEKLNLITADQHQDLLQAYLFLRRVENVLQAINDKQTQLLPADELNRCRLISATCEFTQWDNNHRPQKIQYPIHDWESFYQVLQQHQQKVRSVFNNLIGFNNENEADDSDNAWSDFLDADLEQGEIADILAQQGVSEEERDEIIGRLEAFRHSVSHRSIGIRGREVLTQLMPLLLLQIFSNKKYRTLLPRMLNIVEKILTRTTYLELLLENPQALTQLIELCAKSQLIAEQVAQHPILLDELLDREALLNPPSFEQYPAELQQYLLRLPEDDDEQFITALRQFKQATLLRIAAADILGALPVMKVSDHLTFLAETILHTVVNLAWQQITARFGKPEHLQNNEKGFLVAGYGKLGGIELGYRSDLDLVFLCDEIHSGQTVGGKKVIDSHQFYLRLAQKIISIFSMTTSAGILYEVDLRLRPSGEAGPLCCSFKAFEDYQMNEAWTWEKQSLVRSRAVYGEPALREKFELIRTGILASPRDLTQLKIDVREMREKMYRHFAGADDNKFNIKKDQGGITDIEFIAQYLVLAHAPENPNLAYWSDNVRIFDIMAEHGIITLNEAEKLKNCYTGLRNQIHHLNLLGEPPIVSKEEFADERRFIHQIWQKLFFE

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

977 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

109.433 kDa

MRLPLPSDLPATLQPLVTRNQQFISDAVAGHPELDLQAWSPLHRQQFDQVAAASEFVLSLAQREPAMLFALLASGELERRYAPGELRGQIAATAQAAQSEDELARNLRRARNRQQLRIIWRDITRQAELGETCRDLSDLADAAIDEAYQWLYPRHCQQFGTPIGNRSGQPQHMVVLGMGKLGAVELNLSSDIDLIFGFPEGGETEGVKRSLDNQEFFTRLGQRLIKALDPVTVDGFVFRVDMRLRPYGSAGALVLSFNALEQYYQDQGRDWERYAMIKARVVAGDQAAGAQLQEMLRPFVYRRYLDFSAIEALRTMKQLIQQEVRRKGMAENIKLGAGGIREVEFIAQAFQLIHGGRDLSLQQRPLLKVLATLEGQGYLPPAVVAELREGYEFLRYTEHAIQAIADRQTQMLPEGETDQARVAYVLGFADWQSFHDQLMYWRGRIDWHFRQVIADPDDEDGEGELVVGGEWSPLWEQAQDEEAAGRQLQEAGFKQPAEALRRLAGLRSSPQLRSMQRIGRERLDAFIPRLLAQAVEHDNPDLVLERVLPLVEAVARRSAYLVLLTENPGALRRLLTLCAASPWIAEQIALYPLLLDELLNEGRLFSPPLAPELASELRERLTRIPEDDLEQQMEALRHFKLAHSLRVAASEISGNLPLMKVSDYLTWLAEAILDQVLALAWRQTVARHGQPKRSDGSLCDPGFIIIGYGKMGGLELGHGSDLDLVFIHDGDPQAETDGAKPIDSAQFFTRLGQRIIHLLTTQTNSGQLYDVDMRLRPSGASGLLVSSLGAFERYQQNEAWTWEHQALVRARVLVGCKQVGAAFEGVRAKVLGQARDLEKLRGEVSEMRAKMRDNLGTKATAAGTAANAFDAGVPFDIKQDAGGIVDIEFMVQYAALAWSHDHPAILRWTDNIRILEELEQANLMPASDAVLLREVYKAFRSASHRQALQKEAGVIDAAQFADERREVRRIWGELGLS

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

974 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

110.251 kDa

MKNAFLKTQLLPLRPLDESGSQWLKDITEQARKENLESLVSSLSNQGKQINFLNAVMTLSPFLREVLIANPSYLSPLLYVDIETRLSEIIEDITLIDKNKSIHETTLMAALRRKKREAHVLIALADLGGVFTYEISCAWLTRLGEAALGVALRFLLREAHDHGKINLSNREDPEKDCGLIILGMGKFGAGELNYSSDIDLIVFIDEMSPHVGNLSESIDVFSKMVRRLIRIIQERTAEGYVFRLDFRLRPDPGSTPLALPVRTALRYYEGRGQNWERAAMIKARPVAGDKSAGFNFLKELFPYVWRKYLDYAAIADIHSIKRQIHAYKNYDQISAYGHNIKLGRGGIREIEFFVQTQQLIAGGRFPQLRGRQTVAMLAELHRLGWISEKTRDSLVKSYAFLRNVEHRIQMLADEQTHILPIDVSQFTSVAYLMGYQETNSFICDLLKTLQVVEKHYAALFENEQELGLEIGNLVFTGEEDDPETLITLRRLGFERASDICRIMRTLHCGRYKSTQSAEARERLTELTPALLKAFGATKRADEVMLRFDSFLQGLPSGIQLFSLLQSNPSLLDMLVLIMGAAPRLAEIITHKPHVFDGMLDPTIFSELPTKTYLKNRLEYFLEGVISYEEILDHLRVFADEQRFLIGIRILNGAITGKKAGFAFTALADLIIAKTFATVQEEFSRLHGNIKGGRVGILGMGKLGSCELTAGSDVDLILLYEHDEDAEISDGGKPLYIFQYYTRLTQRLVAALSTLTSQGILYAVDLRLRPLGNKGPVAVSFEFFRKYYRKEAWIWEHLALTRARGIAGDLDFLQKLENEVYEIIAFSRNKKDVIKAVCEMHVLIGKGKPPENRWDLKRMPGGIMHLEFIAQFALITHVIVFQIGATTADILTQLPNSFLNQSFISDLHHAYGLYTNLSQIIRLCLNDALDLNNMPPGLSDLLLSSVGEPDLLRVEKLIEETGQLVYSIFKQVMKY

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

974 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

109.697 kDa

MKNAFLKTHLFPLCPLDESGSQWLKDIEEQARKENLESLVSYFSAKGKQVDFISAVMTLSPFLREVLIANPSYLSPLLYVDIETRLSEIIDDVALIDKSESINETALMAALRRKKREAHILIALADLSGVFTYEISCTWLTRLGEAALGVALRFLLREAHDHGKISLSSRDNPEKDSGLIILGLGKLGAGELNYSSDIDLIVFIDEMSPHIGDLSESVDVFSKMVRRLIRIIQERTAEGYVFRLDFRLRPDPGSTPLALPVRTALRYYEGRGQNWERAAMIKARPVAGDKRAGFKFLKELFPYVWRKYLDYAAIADIHSIKRQIHACKNYGQITAYGHNIKLGRGGIREIEFFVQTQQLIAGGRFPQLRGRQTVAMLTELHTLGWISEKTSDNLIKSYAFLRNVEHRIQMLADEQTHLLPNDVSQFTSVAYLMGYQESSSFIRDLLKVLQVVEKHYAALFENEQELGLEIGNLVFTGEEDDPETLITLSCLGFERASDICRIMRTLHCGRYKATQSAEARERLTELTPALLKAFGAIKRADEAMLRFDSFLQGLPSGIQLFSLLQSNPSLLDMLVLIMGAAPRLAEIITRKPHVFDGMLDPTILSELPTKTYLENRLEYFLEGVIPYEEILDHLRVFADEQRFLIGIRILNGAITGEKAGFAFTALADLMIAKTLAAVQEEFSRIHGNIKGGRVGILGMGKLGSCELTAGSDVDLILVYEHDEDAEISDGEKPLYISQYYTRFTKRLIAALSTLTSQGVLYAVDLRLRPLGNKGPVAVSFEFFRKYYRKEAWIWEYLALTRARGIAGDPNFLQNLENEVCAIIALPHDKKDVAKAVREMRTLIEKEKPPENRWDLKMMSGGIMDVEFIAQFALITHVVAFQIGASTADILAHLPNSVLNQSCIVDLHRAYSLYTNLNQMIRLCLNDAFDPHDMPPGLSDLLLSSVGEPDLLRVEKLIEETAQSVCSIFKQIMKH

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

974 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

110.251 kDa

MKNAFLKTQLLPLRPLDESGSQWLKDITEQARKENLESLVSSLSNQGKQINFLNAVMTLSPFLREVLIANPSYLSPLLYVDIETRLSEIIEDITLIDKNKSIHETTLMAALRRKKREAHVLIALADLGGVFTYEISCAWLTRLGEAALGVALRFLLREAHDHGKINLSNREDPEKDCGLIILGMGKFGAGELNYSSDIDLIVFIDEMSPHVGNLSESIDVFSKMVRRLIRIIQERTAEGYVFRLDFRLRPDPGSTPLALPVRTALRYYEGRGQNWERAAMIKARPVAGDKSAGFNFLKELFPYVWRKYLDYAAIADIHSIKRQIHAYKNYDQISAYGHNIKLGRGGIREIEFFVQTQQLIAGGRFPQLRGRQTVAMLAELHRLGWISEKTRDSLVKSYAFLRNVEHRIQMLADEQTHILPIDVSQFTSVAYLMGYQETNSFICDLLKTLQVVEKHYAALFENEQELGLEIGNLVFTGEEDDPETLITLRRLGFERASDICRIMRTLHCGRYKSTQSAEARERLTELTPALLKAFGATKRADEVMLRFDSFLQGLPSGIQLFSLLQSNPSLLDMLVLIMGAAPRLAEIITHKPHVFDGMLDPTIFSELPTKTYLKNRLEYFLEGVISYEEILDHLRVFADEQRFLIGIRILNGAITGKKAGFAFTALADLIIAKTFATVQEEFSRLHGNIKGGRVGILGMGKLGSCELTAGSDVDLILLYEHDEDAEISDGGKPLYIFQYYTRLTQRLVAALSTLTSQGILYAVDLRLRPLGNKGPVAVSFEFFRKYYRKEAWIWEHLALTRARGIAGDLDFLQKLENEVYEIIAFSRNKKDVIKAVCEMHVLIGKGKPPENRWDLKRMPGGIMHLEFIAQFALITHVIVFQIGATTADILTQLPNSFLNQSFISDLHHAYGLYTNLSQIIRLCLNDALDLNNMPPGLSDLLLSSVGEPDLLRVEKLIEETGQLVYSIFKQVMKY

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

974 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

109.697 kDa

MKNAFLKTHLFPLCPLDESGSQWLKDIEEQARKENLESLVSYFSAKGKQVDFISAVMTLSPFLREVLIANPSYLSPLLYVDIETRLSEIIDDVALIDKSESINETALMAALRRKKREAHILIALADLSGVFTYEISCTWLTRLGEAALGVALRFLLREAHDHGKISLSSRDNPEKDSGLIILGLGKLGAGELNYSSDIDLIVFIDEMSPHIGDLSESVDVFSKMVRRLIRIIQERTAEGYVFRLDFRLRPDPGSTPLALPVRTALRYYEGRGQNWERAAMIKARPVAGDKRAGFKFLKELFPYVWRKYLDYAAIADIHSIKRQIHACKNYGQITAYGHNIKLGRGGIREIEFFVQTQQLIAGGRFPQLRGRQTVAMLTELHTLGWISEKTSDNLIKSYAFLRNVEHRIQMLADEQTHLLPNDVSQFTSVAYLMGYQESSSFIRDLLKVLQVVEKHYAALFENEQELGLEIGNLVFTGEEDDPETLITLSCLGFERASDICRIMRTLHCGRYKATQSAEARERLTELTPALLKAFGAIKRADEAMLRFDSFLQGLPSGIQLFSLLQSNPSLLDMLVLIMGAAPRLAEIITRKPHVFDGMLDPTILSELPTKTYLENRLEYFLEGVIPYEEILDHLRVFADEQRFLIGIRILNGAITGEKAGFAFTALADLMIAKTLAAVQEEFSRIHGNIKGGRVGILGMGKLGSCELTAGSDVDLILVYEHDEDAEISDGEKPLYISQYYTRFTKRLIAALSTLTSQGVLYAVDLRLRPLGNKGPVAVSFEFFRKYYRKEAWIWEYLALTRARGIAGDPNFLQNLENEVCAIIALPHDKKDVAKAVREMRTLIEKEKPPENRWDLKMMSGGIMDVEFIAQFALITHVVAFQIGASTADILAHLPNSVLNQSCIVDLHRAYSLYTNLNQMIRLCLNDAFDPHDMPPGLSDLLLSSVGEPDLLRVEKLIEETAQSVCSIFKQIMKH

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

970 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

109.71 kDa

MNSLPPRPSLDVLPEALRPDLIRLLDDFESACARDGIALDHWPEALVRVWAGSGFAARIAIRRPNLLLELIQDGTLARPLEAGEMAARVSAVVQAAQDEAALMRDLRLLRQREMMRIAWRDLSGEAGLDETLGDLTDLAEHCIDQAAAWVHGQLVQRHGEPRDAEGRPQRLVVLGMGKLGGRELNFSSDVDLIFTYAARGETDGEKPLDNQQFFIRLGQRLIRLLDENTAEGFVFRVDMRLRPFGDAGPLVMDFDTLEGYYESHGREWERYALIKARVVAGDREAGRELMRALRPFVFRRYLDYGAFAALRDMKAMINREAARRSRGDDVKLGEGGIREVEFIGQAFQLIRAGRDPRLQLRGIRPVLRRLAEMELMPGYVVDQLITAYEFLRRTENHLQMAQDQQTHRLPESDEARLRLAFSMGHDDWEGFSRELARHRRRVQEHFQQVFAAPQGEAEEAAGAEGPGQAVLASIWAGDRSGERAQAVLAEAGFRDAPKALEWIEDLREGAACRSLTATGRERLDQLMPLLLGAAAGAEDPDTVLSRLVTLVRSIARRSVYLSLLVESPMALSQLVKLCDASPWIAQLLTRHPLLLDELLDPRSLYAPMDREGLSAELDEELSQVPEDDMEQMMDRLRQFQQVQMLKVAAADIMGVLPLMKVSDHLTWIAEVVLERVLSLVMAQLHARYGRPRCLIDGRPYEPGFAIIGYGKLGGLELGYGSDLDIVFLHDSAGEQQMTDGDKALDNSEFFARLGQRIVHVLGTYTGAGRLYEVDTRLRPSGASGLLVSSLKAFELYQETKAWTWEHQALVRARPVAGDAHIAEGFAEIRRRVLGICRDREKLRQEVREMREKMWSEHASRDPSRFNLKRDPGGIADIEFMVQYWVLAYACDHPPLLDYPDNIRILERLVVTGVLPEEDARFLTDTYREFRNRIHRLTLQESDAVVDAAEFAEQRETVRALWRRVMEEGKA

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

969 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

110.17 kDa

MNWQANIHKLPALLQGRLKNDLARFQEALEQKNLDTVFKAKTLKTLCLVWGASEFVATNCIRWPSLLLDLQGSGNLFRAYEPNHYVKSLAQQLTNISTETELMVVLRRFRQREMVRIVWRDLAGWASLDEVFRELSQLAEACLNSALACLHYWQSQALGTPYGSISGKPQSMVVLGMGKLGARELNLSSDIDLIFAYPESGETRGAQRTLNNEEYFIRLARRLIRVLDERTEEGFVFRVDMRLRPDGDSGPLVASFNAMENYYQNQGRDWERYAMIKARVVAGDCQAGTRLMAMLRPFSYRRYLDFGAIESLRSMKAMIAQELRRQGIKANIKLGPGGIREVEFIGQSFQLIRGGRESALQERGILRVLTLLAERDHLPYYAKEELCAAYVFLRRVEHRLQAYRDEQTHDLPTSTEGRVRLAFAMGYRDWEAFASALEEHRRRVQEHFEQLFAAPHMDITDQMAQEKRLAEVWLGGELREASLAVLSAAGYRAPEEAVQTLMYLRQSYTVRALSAQARIRLDRLMPLLLGAVGRTEYPEQCLQRVIILLETVAQRTAYLALLAEYPMALSQLVKLCAASPLIARQLTRYPLLLDELLDPRSLYQVLGYDSLAEDLKWSLESIPGDDLEQQMELLRHFCQRQTLRVAAADVTGVLPLMKVGDHLTYLAEVILKKALELSWRHLVHRHGRLQSSTGEQPEESGFAVIGYGKLGGYELGYGSDLDLVFLHNAKPGDPPSEGKKPLDPVVFYSRLGQRLIHILQTSTPSGKLYEVDTRLRPSGVSGLLVSGLDAYRGYQCMQAWTWEHQALVRARFVAGDARLGAAFTAMRQEILGRQRDPIKLRDEVRHMRAKMRNQLDRSQGGWFDLKQGRGGIADIEFIVQYGVLAWAHAHPQLLEYPDNIRILEGFAQAGLLASEESQLLADAYRAYRAAANRLNLQTHEARVEEGQFRQERIAVQQLWSALLEDESAK

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

963 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

109.664 kDa

MAAPSELQLYPSVIHPAIQKYWDEFCELPAETLSAFSSYYPDILRAFAVSDFLALNILREPELVLSFLQSSQHQKECQLVDFRAPLAEELSGALKEDDLLRILRLFRRRMMFRIIWRDLVCLVDYQVTTREVSWLAETCIDEALSWIYRDMSQQFGEPHSTAGVKQQLVVLAMGKLGANELNVSSDIDLIFTFPERGETQGGNRSLDNQAFFTRLGQRLIQALDNTTADGFVFRVDMRLRPYGQSGALALSFAAMEAYYQEQGRDWERYAMIKARAVAGDIDAGEELLTSLKPFVYRKYIDFGAVQALRAMKEMIEREVQRKGQDGNIKVGRGGIREIEFIVQVFQLMRGGRDVRLQQRNLLSTLECLEDEGLLPVAAAAELREAYIFLRNLEHAIQGLEDKQTQEIPKDEEGRERVAVAMGFPGWGACRVQLDKYRDCVSEHFADIIAERREAPLERPDTIEWKALWAGRLAQDEAQDLLLRSGCDQAQEIYEAVTQLRQSSRVQHMQLQGKERLDEFMPNLLQSLAQSRASHETCRRLLALVEAVLRRSAYLALLNENPGALTELIRLFAESAWIARQIVTTPLLLDELLHSGSLYTPPDTTALRDELRQQMLRIPNDDLEEQMEALRYFKKAHVLRVAASDLRETLPLMKVSDYLTFIAETIIEQVVDEAWETMVKKYGEPGYEDAALNDMRFAVIGYGKLGGIEMSYGSDLDLVFLHGASGDLSTSGETSIANQVFFTRLGQRIIHLLTTKTASGDIYEVDMRLRPSGNSGLLVSSVSAFQQYQEKSAWTWEHQALVRSRAVAGCPGIRAEFEKVRKDILTQHRDPAKLRTEVMDMREKMHASLGTKPDSSGSPPYFDLKHDRGGIVDIEFMVQYAALRWANEYPQIVVWSDNIRILEALGDAGVFSQEDADKLCDIYRLLRAHGHRLALQNLPARIQTDELLEERRWVVAFWEKVFAE

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

963 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

111.282 kDa

MLTTLIPLSQLNLPPNLQNSEQIQPLVTAEFASNFVHQTLQKQPDLLAEWLAKFPTPDDCCNYTERLAKILARVPNEEMLGRVLRQFRHRELARLSFIQSNKLATVELVFQHLSDLAESLILAARDWLFQRCCAEYGTPKNTLGETQELLILGMGKLGGRELNFSSDIDLIFTYPDIGETEGGRKSIENSKFFTRMAQRLIKVLDEITADGFVYRTDMRLRPFGDSGRLVLSFTAMEDYYQEQGRDWERYAMIKAKILGEDSQNLNHRYLKQMLRPFVYRRYLDFSAIQSLREMKEKISREVVRRNLTDNIKFGAGGIREVEFIAQTFQMIRGGRDKILQERSLLKVLPRLAELNLLTQTQVETLHNAYIFYRQIENVLQAIDDKQTQTLPTDEASQARLVFACQSYYQQDLYSEKTHWVEHSFNDWQQFMAVLSQYQQAVRQIFNEIIGEEETQANCNPVNEKLAEWKDILHYNIRLEDLSAVLKGYPKVAENDYTEIFRHFSTTFQDWVKRPIGVRGREVLRNLMPRIADSIFKGEDHLLLLPRVLNIVDKITTRTTYLELMLEKEQILPQLLALCSKSVMIAEQIARYPMLLDELMSHRGLTDVQAFEKYQSALQDYLIRIPEEDEEALIDGLRQFKQTQILRIAAADILGVLLVMKISDHLTYLAEAIINAVVNMAWKQVSQRFGVPEHLEADEKGFAVIGYGKLGGIELGYNSDLDLVFLHNAPEDSQTVGGKKEISSHQFYLKLAQKINSIFNLNTSAGVLYEVDMRLRPSGEAGLLVSTFNAYEHYQKNEAWTWESQALVRTRCVFGAENLKQAFEKIRQSTLAQPRASGQLRQEICEMRQKMYQHLSSHSAEQFHIKQDQGGITDIEFIAQYLVLAHSHQHPKMAVWSDNVRIFDSAVECGILSSEQSEQLQHCYTALRNKIHHLKLLRKDSVVDASEFTTERAFVREMWQRLLA

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

963 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

109.664 kDa

MAAPSELQLYPSVIHPAIQKYWDEFCELPAETLSAFSSYYPDILRAFAVSDFLALNILREPELVLSFLQSSQHQKECQLVDFRAPLAEELSGALKEDDLLRILRLFRRRMMFRIIWRDLVCLVDYQVTTREVSWLAETCIDEALSWIYRDMSQQFGEPHSTAGVKQQLVVLAMGKLGANELNVSSDIDLIFTFPERGETQGGNRSLDNQAFFTRLGQRLIQALDNTTADGFVFRVDMRLRPYGQSGALALSFAAMEAYYQEQGRDWERYAMIKARAVAGDIDAGEELLTSLKPFVYRKYIDFGAVQALRAMKEMIEREVQRKGQDGNIKVGRGGIREIEFIVQVFQLMRGGRDVRLQQRNLLSTLECLEDEGLLPVAAAAELREAYIFLRNLEHAIQGLEDKQTQEIPKDEEGRERVAVAMGFPGWGACRVQLDKYRDCVSEHFADIIAERREAPLERPDTIEWKALWAGRLAQDEAQDLLLRSGCDQAQEIYEAVTQLRQSSRVQHMQLQGKERLDEFMPNLLQSLAQSRASHETCRRLLALVEAVLRRSAYLALLNENPGALTELIRLFAESAWIARQIVTTPLLLDELLHSGSLYTPPDTTALRDELRQQMLRIPNDDLEEQMEALRYFKKAHVLRVAASDLRETLPLMKVSDYLTFIAETIIEQVVDEAWETMVKKYGEPGYEDAALNDMRFAVIGYGKLGGIEMSYGSDLDLVFLHGASGDLSTSGETSIANQVFFTRLGQRIIHLLTTKTASGDIYEVDMRLRPSGNSGLLVSSVSAFQQYQEKSAWTWEHQALVRSRAVAGCPGIRAEFEKVRKDILTQHRDPAKLRTEVMDMREKMHASLGTKPDSSGSPPYFDLKHDRGGIVDIEFMVQYAALRWANEYPQIVVWSDNIRILEALGDAGVFSQEDADKLCDIYRLLRAHGHRLALQNLPARIQTDELLEERRWVVAFWEKVFAE

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

963 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

111.282 kDa

MLTTLIPLSQLNLPPNLQNSEQIQPLVTAEFASNFVHQTLQKQPDLLAEWLAKFPTPDDCCNYTERLAKILARVPNEEMLGRVLRQFRHRELARLSFIQSNKLATVELVFQHLSDLAESLILAARDWLFQRCCAEYGTPKNTLGETQELLILGMGKLGGRELNFSSDIDLIFTYPDIGETEGGRKSIENSKFFTRMAQRLIKVLDEITADGFVYRTDMRLRPFGDSGRLVLSFTAMEDYYQEQGRDWERYAMIKAKILGEDSQNLNHRYLKQMLRPFVYRRYLDFSAIQSLREMKEKISREVVRRNLTDNIKFGAGGIREVEFIAQTFQMIRGGRDKILQERSLLKVLPRLAELNLLTQTQVETLHNAYIFYRQIENVLQAIDDKQTQTLPTDEASQARLVFACQSYYQQDLYSEKTHWVEHSFNDWQQFMAVLSQYQQAVRQIFNEIIGEEETQANCNPVNEKLAEWKDILHYNIRLEDLSAVLKGYPKVAENDYTEIFRHFSTTFQDWVKRPIGVRGREVLRNLMPRIADSIFKGEDHLLLLPRVLNIVDKITTRTTYLELMLEKEQILPQLLALCSKSVMIAEQIARYPMLLDELMSHRGLTDVQAFEKYQSALQDYLIRIPEEDEEALIDGLRQFKQTQILRIAAADILGVLLVMKISDHLTYLAEAIINAVVNMAWKQVSQRFGVPEHLEADEKGFAVIGYGKLGGIELGYNSDLDLVFLHNAPEDSQTVGGKKEISSHQFYLKLAQKINSIFNLNTSAGVLYEVDMRLRPSGEAGLLVSTFNAYEHYQKNEAWTWESQALVRTRCVFGAENLKQAFEKIRQSTLAQPRASGQLRQEICEMRQKMYQHLSSHSAEQFHIKQDQGGITDIEFIAQYLVLAHSHQHPKMAVWSDNVRIFDSAVECGILSSEQSEQLQHCYTALRNKIHHLKLLRKDSVVDASEFTTERAFVREMWQRLLA

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

961 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.978 kDa

MSQQHQAEIPKEIKEKGSLWLASLEAHHPESLTGLDTVQRRELEQVAGLSDFIARELSRHPERIARLFDGLLDKVDRSAFDRELHQALASVTSEDEAKAVLRRYRNFQMARLAWRDFTGKAPLGESLLDISSLAEALIITGRDWLYREMCQSLGTPMDADGRPQPLMILGMGKLGGRELNFSSDIDLIFTFPEHGETQGGRKSLDNQQFFIRMGQRLVNLLSQVTVDGFVFRVDMRLRPYGESGPLVVSFSALEDYYQEQGRDWERYAMVKARALGPWSGYSDELHSLLRPFVYRRYIDFSAIESLRRMKQLIAQEVRRRHLTDNIKLGAGGIREVEFVVQSFQLIRGGREPSLRTQSLFGAIDTLYSLGQLEYLAVDELKNAYVLLRRAENLLQAIDDKQTQTLPDNSLDWQRLCCALEMANEFDLRAHIEAAMAKIHRHFRATVGGEEAEDNHEHWTWQFWNVQEEDHAEALLQDQHIDDPALWPLLKGWRETMSRRPIGPRGRETLDRLMPKLLGELVSMPIPSAAFAPVFNVVEQVLTRTTYLELLCENPGARAQLVSLCCASPWIADQLAKFPMLLDELIDPAALYDITSLDDYGSELRQYLLRVPEDDMEQQMEALRQFKLTQQLKIAAADVTGVLPIMQVSDHLTFLAEAIIEQVVHQAWGQVASRHGVPAHLESGQMGFAVIAYGKLGGIELGYGSDLDLVFLHNYQGSGLTTGERQIETSHFYLKLAQRILHLFSTRTTSGELYEVDMRLRPSGASGLLVSEIERFGEYQQQEAWTWEHQALVRSRFVFGDNQLAARFSEIRAEVLGKVRDPAVLKGEVKAMRTKMREHLLKVDEGMFDLKQSPGGIADIEFIAQYLVLAGSAEFEDLTVWSDNVRIFQTAAELDILPLPVAQQLIAAYCTLRDENHRLTLQREAGQLPAIAVAEHSERVCAIYADVLGHDTDEPPLESRSQ

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

957 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

110.4 kDa

MFSQLDFTGLPLANTGENRPLAIAVAMSNFVKKTLQKQADLRDDWQRKLPTLADCGNYAERLTIYLSTINDEVQLSHCLRNFRHREMARLSFIQSNKLATVEFVFEQLSDLAEAIILAARDWLFTRCCAEYGTPVNGLGEIQPLLIIGMGKLGGRELNFSSDIDLIFTYPEAGQTVGGHKTIENSKFFTRLGQRLIKALDEITVDGFVYRTDMRLRPFGDNGALVLSFAAMEDYYQEQGRDWERYAMIKAKILGEDLTDVNHRYLQQMLRPFVYRRYLDFSAIQSLREMKQKISREVLRRNLQDNIKLGAGGIREIEFIVQTFQMIRGGRDKILQQRSLLQVLPHLVTLNLLTKQQAKHLGDAYIFHRQLENVLQAIDDQQTQSLPADAKNQARIMYACQSYWQKDQQNQPLMIEYHWQSWQQFLSTLAQHQQHVRVIFNQLIGEEEQANQSPVNEQLAIWQDILHPEIRQLELAEVLRDYPVATEDYATIFHLLANTLQDWSKRPIGVRGRKVLSQLMPKVMHSICSKTDYLVVLPRLLNIIDRVTTRTTYLELLQEKDQILPLLERLCGHSIMVAEQIARYPMLLDEFIINKSLMKVIEFEQYKTELTEYLIRIPEEDEEALIDALRQFKQGHLLRIAVADILGVLPVMKISDHLTYLAAAIISEVVNMAWKSLVKRFGKPTHLAEDERGFAVIAYGKLGGLELGYNSDLDLVFLHNAPLEGETSGRRSISNHQFYLKLAQKINSIFNLNTSAGVLYEVDMRLRPSGDAGLLVSTFQAYQYYQQHEAWTWETQALVRGRCVYGSASLIDEFSRIRRTTLCLARTRGRLRQEISQMRHKMYQHLTKTSTGQFNLKTDQGGITDIEFIAQSIVLEYAHCYPEMAKWSDNVRIFTAAIECGILSQHIGEGLKNAYTRIRNRIHQLNLLQLPSIVNDTEFVSERAFVTKIWQQIFTDNE

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

957 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

110.4 kDa

MFSQLDFTGLPLANTGENRPLAIAVAMSNFVKKTLQKQADLRDDWQRKLPTLADCGNYAERLTIYLSTINDEVQLSHCLRNFRHREMARLSFIQSNKLATVEFVFEQLSDLAEAIILAARDWLFTRCCAEYGTPVNGLGEIQPLLIIGMGKLGGRELNFSSDIDLIFTYPEAGQTVGGHKTIENSKFFTRLGQRLIKALDEITVDGFVYRTDMRLRPFGDNGALVLSFAAMEDYYQEQGRDWERYAMIKAKILGEDLTDVNHRYLQQMLRPFVYRRYLDFSAIQSLREMKQKISREVLRRNLQDNIKLGAGGIREIEFIVQTFQMIRGGRDKILQQRSLLQVLPHLVTLNLLTKQQAKHLGDAYIFHRQLENVLQAIDDQQTQSLPADAKNQARIMYACQSYWQKDQQNQPLMIEYHWQSWQQFLSTLAQHQQHVRVIFNQLIGEEEQANQSPVNEQLAIWQDILHPEIRQLELAEVLRDYPVATEDYATIFHLLANTLQDWSKRPIGVRGRKVLSQLMPKVMHSICSKTDYLVVLPRLLNIIDRVTTRTTYLELLQEKDQILPLLERLCGHSIMVAEQIARYPMLLDEFIINKSLMKVIEFEQYKTELTEYLIRIPEEDEEALIDALRQFKQGHLLRIAVADILGVLPVMKISDHLTYLAAAIISEVVNMAWKSLVKRFGKPTHLAEDERGFAVIAYGKLGGLELGYNSDLDLVFLHNAPLEGETSGRRSISNHQFYLKLAQKINSIFNLNTSAGVLYEVDMRLRPSGDAGLLVSTFQAYQYYQQHEAWTWETQALVRGRCVYGSASLIDEFSRIRRTTLCLARTRGRLRQEISQMRHKMYQHLTKTSTGQFNLKTDQGGITDIEFIAQSIVLEYAHCYPEMAKWSDNVRIFTAAIECGILSQHIGEGLKNAYTRIRNRIHQLNLLQLPSIVNDTEFVSERAFVTKIWQQIFTDNE

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

957 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.957 kDa

MTQHLERPELLSIAATKALDKLQQAHPELLAQWPTERQNELETVIGLSDFIASSLVCDGQLLLWLSEHLDDKEHAEQYRQQLETKLATTADDVGLMRQLRAFRRQEMVWIAWRDFTNKSTLEQSLAHLSQLAEALIMEAYQWLYNQCCKEWGTPTNSAGEAQPMLVLGMGKLGGGELNFSSDIDLIFTYPENGDTVGGRRSMANAQFFTRLGQRLIKALDQPTYDGFCYRVDMRLRPFGDSGPLVMSYAALEDYYQEQGRDWERYAMIKARVMGRESFTQYQELRQMLRPFVFRRYIDFSAIQALRRMKSMISSEVRRRGLSNNIKLGAGGIREVEFIAQSFQLIRGGREPSLRGRGLLETLAAMKQLALLPEKQIEHLEQGYCFLRKLENLLQAIDDKQTQTLPDKPLDQIRLAFAMGYADWQSLFEAIELHMSAVHLVFDDIIGTDEDDAGCSVSEQYNEMWTMAKDEDVLLNIMAELEAPDSANQVSTILGMKAELSKRTLGPRGREVLTRLMPEVLSRIVPRPDASAVLARVTKLIVRVATRTTYLELLGEHPAALGQLIRLCAASPMVAEQLTQYPILLDELLDPQHLYNPTPLDQYGDELREYLARIPEEDMEQQMEAIRQYKQAQLLRIAAADIAGALPLMAVSDHLTYLAEAIITAVVNQAWLQMAEKYGEPTHLVDRNGKGFGVIGYGKVGGWELGYGSDLDVVFLHDCPADIYTNGKKEIDGRQFYLRLAQRIVHLFSTRTSSGVLYEIDVRLRPSGASGLLVSTVESFDEYQQKEAWTWEHQALVRARMIYGDVPLFDAFSDVRKRILTQPRDTQSLQVDVVSMRHKMRVHLGSKKNGMFGLKQDKGGITDIEFLAQYLVLQHSHTEPYLTRWSDNVRIFDTMAECEVLSLSQASALKQAYCVMRDDIHRLNLLGLPVYVDESQFVTERETVQQIWQEYLVPSSDE

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

956 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

109.698 kDa

MENMSEQALPHEVNQVAEQHWQRLAEAWPDISEQLTPEQTKELKTIFGLSDFVAEQLCRHPNWIVSLFEGQLSMLARDSFSSELHSILAGANDEEQVKAILRRYRNRQMVRLAWRDFLGYAELNDSLLDLSALAEALIIAARDWLYGQMCQQYGTPCDSEGNPQPLMILGMGKLGGRELNFSSDIDLIFTFPEHGETQGGRRSQDNQQFFIRMGQRLVNLLNQVTVDGFVYRVDMRLRPYGESGPLVVSFSGLEDYYQEQGRDWERYAMVKARALGPWSAYSDELHDMLRPFVYRRYIDFSAIESLRKMKQLITQEVRRRRLTDNIKLGAGGIREVEFVVQSFQLIRGGREPALRQQSLFGAIDTLYKLGQLEYLAVDELKQSYLMLRRVENLLQAIGDQQTQTLPQHLLDWQRLCFALGMAGEAELRTHIESAMAKIHRYFKETVGGQESDEVAEQWTAQLWSLVDDEDAEALLKEHGVEESELWPALKSWRGTVAKRTIGPRGRETLDKLMPWLLQEFIQLPTPTKAFLPVSKVLDQILTRTTYLELLFENPGARQQLVSLCMASPWIGEQLAKFPMLLDELIDPAQLYDTTSLDDYPSELRQYLLRVPEEDMEQQMEALRQFKLSQQLKIAAADVTGVLPVMQVSDHLTFLAEAIIEQVVLQAWQQVSKRHGTPSYLAPEEMGFAVIGYGKAGGLELGYGSDLDLVFLHNYTRDKYPDAQQTNGDRPIDIGHFYLKLAQRILHLFSTRTTSGELYEVDMRLRPSGASGLLVSEIEYFGSYQREEAWTWEHQALVRARFLFGDNRLAARFSELRADVLAMERDKAELAKEVREMRQKMRTHLLKVDEGCFDLKQSPGGIADIEFIAQYLVLANTHDHPELAIWSDNVRIFEVLSELELLPHLSAQHLTQAYCYLRDESHRLTLQQAPGQLPQESVDLHVQRVLAIYEQVLNNGQ

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

956 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

110.384 kDa

MLPLSTPLLAQLQRVTEHFHQLTLNVEPVAAHEQAILSLSDFVVENLQAHPEWLVEIRQHPPEAQEWHQYTEWLQQLLASVEDENTLMRVLRQFRNKILVRIAWSQALHSITTQETLQQLSMLAETLIIAARDWLYQRCCQDWGTPCNERGEPQPLLIIGMGKLGGGELNFSSDIDLIFVYPENGITQGGRREMDNTQFFTRLGQHLIKVLDQQTVDGFVYRVDMRLRPFGDSGPLVFSFVALEDYYQEQGRDWERYAMVKARIMGSDNQAYGEELRRMLRPFIFRRYIDFSVIQSLRNMKGMIEREVRHRGLKDNIKLGAGGIREIEFIAQVFQLIRGGRELCLQSQALLPTLQIIAKLTLLQSLQVKQLADGYLFLRRLENLLQSINDQQTQTLPEDELNRSRLTWGMGFESWDALIIELNNKMSAVRAIFTQLIGDDSDNSDEEPSHVPFKSLWLEDLEKEELIILAPHLDEEIAQQILHIISVFRHDVGKRTIGPRGRDVLDHLMPRLLAKVCLRQDANNQDVNNRNVNIVLERVIPLLLSIVSRTTYLELILESEAVLAHVIRLCAASPMIATQLACHPLLLDELLDPQFLYEPLPLNAYKDELRQYLLRIPEDDEEQQLEALRQFKQAQLLRIAAEDITGVLPVMKVSDHLTYLAEAIIEAVVLQAWGQMAKRYGVPSHLSQRQGLGFAVIGYGKLGGWELGYGSDLDLVFLLDCPMDVMTDGDRSIDARQFYLRLAQRIMHLFSARTSSGVLYDVDVRLRPSGESGMLVSTIGAFADYQRNQAWTWEHQALVRARMVFGDENLHRDFERIRHQTLCTRREPALLRQQVREMREKMHKHLGSHHSDQFDIKADPGGITDIEFIAQYLVLRYAAENERLVRWSDNVRIFQLMAAYEIMDEDEAAGLTQAYVSMRDELHHLTLQTHSSRVSIHCFSEQQERVRRSWQQWLGE

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

955 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

106.37 kDa

MTAQAPLSVAPFLQTPACPSEAPGAVLPFSLNYSRYVQRLAQARAGWAERVQAAAAGPISVAWLSARFGELFEAAAAEPEQALKRALRLLRNEVFAALAERDLSGAATLDEVTGAMTDFAEFAVRAAIAVIGQELGALHGQPVGQSSGEVQELVVVGMGKLGGRELNVSSDIDLIFLYDEEGDTQGGPRPLSNHEYFTKLGRRLINALADVTEDGYVFRVDMRLRPNGDAGPLACSLGMLEEYFVVQGREWERYAWIKGRVITDPGSPHAARVIQQLERVTTPFVFRRYLDYGVIAAIRALHAQIRAEAAKRSNAANRQHGGHDSQVQAHAPNIKLGRGGIREIEFVAQVFQLIRGGQDFGLRIRPTLEVLRAAAERGLIGADAVARLTDAYRFLRQLEHRLQYVDDAQTHNLPGAPEDQLRIARMMGFADYAALVAQLERYQDEVAQQFEQTFSDKQDNQPPCAAIWHADLLDDERTESARAQLLELGYADADSVLERLRASRHSPRYRALSEVSRQRFDLLINRALDHAARQTDADVTIARFLDFFDAISRRSSYLSLLSEYPQAMARVAHTLHASRWAADYLTRHPQLLDELLDTEALSAAPDWQGFRERVRERLRAAGDHVEMQMDILRQEHHAETFRILLQDLQGMLTVEPISDRLSDLADAVLDLTLETVWQQVSTRHREVPRFAVVAYGRLGGKELGYASDLDLIFLYDDDDERAPEVYAAYARKLITWLTSHTAAGMLFDVDTRLRPNGAAGLMVTHFEAFRRYQMREGDNAAWVWEHQALTRARFCAGDPEIGARFEALRIAVLRQPREAGPLRDEIAAMRERVLEGHANPTPLFDLKHDRGGMVDIEFTVQFLVLLHSAAYAELTRNAGNIALLRMAGELGLIDAARAARVADAYRDFRARQHKLRLDGQSAARVPAGTCAHEAAHVRALWEQVFGSIDAASPTP

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

954 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

109.152 kDa

MAVQKDSNKSLSPLITQASERHWARLTEVWSEGLANLTAAQQQELKTVLGLSDYIANQLTRSPEWINALFADDLQQVERKLFDAQLREQLASATTEDMAKRLLRRFRNYQMVRFAWRDFLDYASLEESLLDLSALAEALVIGARDWLYKEMCVQYGTPMDKAGNPQPLLILGMGKLGGRELNFSSDIDLIFTFPEHGETVGGRRSLDNQQFFIRMGQRLVNLLDQITVDGFVFRVDMRLRPYGESGPLVVSFSGLEDYYQEQGRDWERYAMVKARSLGPWNHFSDELHSLLRPFVYRRYIDFSAIESLRKMKQLIAQEVRRRQLTDNIKLGAGGIREVEFVVQSFQLIRGGREPSLRQQSLFGAMDTLYSLGQFEYLAVDELKHSYLLLRRVENLLQAIDDKQTQTLPNNALDWARLCYVLDMTNEIDLRTHIEAAMAKIHRHFKATVGGEEGEEKAEHWTAQLWNVQQDDHAINLLAEQQIDDDKLWPLLSRWRETVTKRSIGPRGRETLDKLMPRLLDELLNQPSPSAAFEPVSKVLEQILTRTTYLELLCENPGARQQLVSLCCASPWIAVQLAKFPMLLDELIDPAHLYDTTSLDDYPSELRQYLLRVPEDDMEQQMEALRQFKLSQQLKIAAADVTGVLPVMQVSDHLTFLAEAIIEQVVMQAWQQVAVRHGVPSYLAESSDTGFAVIGYGKLGGIELGYGSDLDLVFLYEAPENMANSLTNGDRPIEVGHFYLKLAQRILHLFSTRTTSGELYEVDMRLRPSGASGLMVSEIARFGEYQAQEAWTWEHQALVRSRFVFGDNSLAVKFSQIRACVLEQSRDKDELKKAVREMRQKMRDHLLKVSEGEFDLKQSPGGITDIEFIAQYLVLANAHEYPELSIWSDNVRIFGVLAELELLPLMSAQHLTQSYCWLRDENHRLTLQQKSGKLAYADVAAHAERILAIYQAILE

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

954 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

109.905 kDa

MENISNKSLPAIITDVADRYWQRLNEAWPELSTLIDKKHCDELYRIMGVSDFIAEQLCRHPDWIPALFDGQLVKVERLSFDRELHELMEPCRSEDEAKAILRCYRNRLMVRLAWRDFFGYVSLEDSLLDLSALSEALIIAGRDWLYRELCQQYGTPCDREGNPQPLMVIGMGKLGGRELNFSSDIDLIFTFPEHGETQGGRRALDNQQFFIKMGQRLVNLLHQVTVDGFVYRVDMRLRPYGESGPLVVSFSALEDYYQEQGRDWERYAMVKARALGPWTAFSDELHSMLRPFVYRRYIDFSAIESLRKMKQLITQEVRRRKLTDNIKLGAGGIREVEFVVQSFQLIRGGREPSLRQQSLFAAIDTLYTLGQLEYLAVDDLKQSYLLLRRVENLLQAIGDRQTQTLPDNGLDWYRLCHCMGMASEAELRTHIESAMSKIHRHFNDTVGGNEQDESSQLWTQQLWSVQEDEHAQALISEQSIEDPDLWPMLKSWRDTIAKRSIGPRGRDTLDKLMPWLLRELTPLVSPSKAFEPVSKVLDQILTRTTYLELLYENPGARQQLVSLCCASPWISAQLAKFPMLLDELIDPAQLYDTTSLDDYGSELRQYLLRVPEEDMEQQMEGLRQFKLSQQLKIAAADVTGVLPVSQVSNHLTLLAEAIIEQVVMQAWLQVSSRHGVPTHLDEGDMGFAVIGYGKAGGIELGYGSDLDLVFLHSYSRERFPENTETNGERPIEVGHFYLKLAQRILHLFSTRTNSGELYEVDMRLRPSGASGLLVSEIEHFGQYQREEAWTWEHQALVRARFMFGDNALSSRFSTLRSEVLQLHREKETLAQEVREMRLKMREHLLKVSPDMFDLKQSAGGIADIEFIAQYLVLANANEHSELSIWSDNIRIFSTLGELALLPQLDAQELIQAYLFLRDENHRLTLQQKPGQLALELVELHAQRVIEIYQNVLEF

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

954 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

109.177 kDa

MENISNKPLSAIISEVADRYWQRINDVFPELANELTKEQGEELYRIMGLSDFIADQLCRHPQWILSLFNGELNNLSRSEFDKDLHGLLSECQSEDEANRVLRCYRNKQMVRLAWRDFLGYASLENSLLDLSALAEALIISARDWLYIQACKQYGTPMDSEGNPQPLIILGMGKLGGRELNFSSDIDLIFTFPEHGETQGGRRAIENQQFFIRMGQRLVNMLHQVTVDGFVYRVDMRLRPYGESGPLVVSFSGLEDYYQEQGRDWERYAMVKARALGPWTAFSDELHSMLRPFVYRRYIDFSAIESLRKMKQLITQEVRRRQLTDNIKLGAGGIREVEFVVQSFQLIRGGREPSLRQQSLFAAIDTLYQLGQLEYLAVDELKQSYLLLRRVENLLQGIGDQQTQTLPDSGLNWYRLCHCMGMASEAELRTHIESAMSKIHRHFIETVGGRTQDEGADLWTQQLWIAYEDDDAQTLIKEQMIDDPELWPQLKSWRETVANRSIGPRGRDTLDKLMPWLLREFTNLPTPSDALNSVSKVIDQILTRTTYLELLYENPGARQQLVSLCCASPWIAAQLAKFPMLLDELIDPTQLYDTTSLDDYGSELRQYLLRVPEEDMEQQMEALRQFKLSQQLKIAAADVTGVLPVSQVSDHLTLLSEAIIEQVVMQAWQQVTARHGVPAYLEEGVTGFAVIGYGKAGGIELGYGSDLDLVFLHSFSREKYPDQGETDGDRPIEVGHFYLKLAQRILHLFSTRTTSGELYEVDMRLRPSGASGLLVSEIEYFGEYQREEAWTWEHQALVRARFMFGSNGLSSRFSELRSEVLQLARDGSDLAKAVRDMRTKMRDHLLKVKTGHFDLKQSAGGIADIEFIAQYLVLANANQHNELSFWSDNIRIFTGLGELGILAHADVESLIQAYLFLRDESHRQTLQQKPGELPLDLVAEHANRVMDIYQRILVD

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

951 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.33 kDa

MLPLPSELQIQAQSIKQRFSELPAPPDLRDEDIAVLALSDFVSDMLLIHPQWLEELHQQPPQPQEWQYYSQWLSQALAGVQDEAALLTALRLFRRRVMVRIAWSQVLQTSGTAETLQQLSTLAESMIIAARDWLYQVCCRELGTPCNRQGVPQPLLILGMGKLGGGELNFSSDIDLIFAYPENGQTQGGRRELDNAQFFTRLGQRLIKALDQHTIDGFVYRVDMRLRPFGDSGPLVLSFAALEDYYQEQGRDWERYAMVKARLMGGADDPYSQELRQMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLKDNIKLGAGGIREIEFITQVFQLIRGGREPRLQERALLPTLQAVAELGLLPEQQVADLSGSYLFLRRLENLLQAIADEQTQTLPNDPLNQARLAWGMGYADWAAMSTALENHMQAVRVVFDDLIGDETPDIGEDPSHGLYKSLWQDVLEESDLAPLTPHLEEAARRQLLATISGFRHDVDKRTIGPRGREVLDQLMPRLFAEVCPRPDANVALSRLILLLLSIVTRTTYLELLVEYHAALKHVIRLCSASPMVASQLARYPLLLDELLDPQSLYQPLAPSAYRDELRQYLLRVPEDDEEQQLEALRQFKQAQQLRIAAGDITEALPVMKVSDHLTYLAEAIIDAVIQQAWNQMVARYGQPSHLQQSEGRGFAVIGYGKLGGWELGYSSDLDLVFLLDCPLDVMTDGDRSIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGEAGMLVSTIEAFADYQRNEAWTWEHQALVRARIVYGSPKLHQQFDAIRQQILCRHREDPQLQQEVREMREKMRNHLGSKQRDIFDIKADAGGITDIEFIAQYLVLRYAASEPRLTRWSDNVRIFESMAHYDIMSPEEAAALTRAYVTMRDEIHHLALQEQSSKVAADSFIAEREQVAASWHKWLAANDANVS

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

951 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.358 kDa

MLPLPSELQIQAQSIKQRFSELPVPPDLRDEDIAVLALSDFVSDMLLIHPQWLEELHQQPPQPQEWQYYSQWLSQALAGVQDEAALLTALRLFRRRVMVRIAWSQVLQTSGTAETLQQLSTLAESMIIAARDWLYQVCCRELGTPCNRQGVPQPLLILGMGKLGGGELNFSSDIDLIFAYPENGQTQGGRRELDNAQFFTRLGQRLIKALDQHTIDGFVYRVDMRLRPFGDSGPLVLSFAALEDYYQEQGRDWERYAMVKARLMGGADDPYSQELRQMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLKDNIKLGAGGIREIEFITQVFQLIRGGREPRLQERALLPTLQAVAELGLLPEQQVADLSGSYLFLRRLENLLQAIADEQTQTLPNDPLNQARLAWGMGYADWAAMSTALENHMQAVRVVFDDLIGDETPDIGEDPSHGLYKSLWQDVLEESDLAPLTPHLEEAARRQLLATISGFRHDVDKRTIGPRGREVLDQLMPRLFAEVCPRPDANVALSRLILLLLSIVTRTTYLELLVEYHAALKHVIRLCSASPMVASQLARYPLLLDELLDPQSLYQPLAPSAYRDELRQYLLRVPEDDEEQQLEALRQFKQAQQLRIAAGDITEALPVMKVSDHLTYLAEAIIDAVIQQAWNQMVARYGQPSHLQQSEGRGFAVIGYGKLGGWELGYSSDLDLVFLLDCPLDVMTDGDRSIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGEAGMLVSTIEAFADYQRNEAWTWEHQALVRARIVYGSPKLHQQFDAIRQQILCRHREDPQLQQEVREMREKMRNHLGSKQRDIFDIKADAGGITDIEFIAQYLVLRYAASEPRLTRWSDNVRIFESMAHYDIMSPEEAAALTRAYVTMRDEIHHLALQEQSSKVAADSFIAEREQVAASWHKWLAANDANVS

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

951 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.33 kDa

MLPLPSELQIQAQSIKQRFSELPAPPDLRDEDIAVLALSDFVSDMLLIHPQWLEELHQQPPQPQEWQYYSQWLSQALAGVQDEAALLTALRLFRRRVMVRIAWSQVLQTSGTAETLQQLSTLAESMIIAARDWLYQVCCRELGTPCNRQGVPQPLLILGMGKLGGGELNFSSDIDLIFAYPENGQTQGGRRELDNAQFFTRLGQRLIKALDQHTIDGFVYRVDMRLRPFGDSGPLVLSFAALEDYYQEQGRDWERYAMVKARLMGGADDPYSQELRQMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLKDNIKLGAGGIREIEFITQVFQLIRGGREPRLQERALLPTLQAVAELGLLPEQQVADLSGSYLFLRRLENLLQAIADEQTQTLPNDPLNQARLAWGMGYADWAAMSTALENHMQAVRVVFDDLIGDETPDIGEDPSHGLYKSLWQDVLEESDLAPLTPHLEEAARRQLLATISGFRHDVDKRTIGPRGREVLDQLMPRLFAEVCPRPDANVALSRLILLLLSIVTRTTYLELLVEYHAALKHVIRLCSASPMVASQLARYPLLLDELLDPQSLYQPLAPSAYRDELRQYLLRVPEDDEEQQLEALRQFKQAQQLRIAAGDITEALPVMKVSDHLTYLAEAIIDAVIQQAWNQMVARYGQPSHLQQSEGRGFAVIGYGKLGGWELGYSSDLDLVFLLDCPLDVMTDGDRSIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGEAGMLVSTIEAFADYQRNEAWTWEHQALVRARIVYGSPKLHQQFDAIRQQILCRHREDPQLQQEVREMREKMRNHLGSKQRDIFDIKADAGGITDIEFIAQYLVLRYAASEPRLTRWSDNVRIFESMAHYDIMSPEEAAALTRAYVTMRDEIHHLALQEQSSKVAADSFIAEREQVAASWHKWLAANDANVS

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

951 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.358 kDa

MLPLPSELQIQAQSIKQRFSELPVPPDLRDEDIAVLALSDFVSDMLLIHPQWLEELHQQPPQPQEWQYYSQWLSQALAGVQDEAALLTALRLFRRRVMVRIAWSQVLQTSGTAETLQQLSTLAESMIIAARDWLYQVCCRELGTPCNRQGVPQPLLILGMGKLGGGELNFSSDIDLIFAYPENGQTQGGRRELDNAQFFTRLGQRLIKALDQHTIDGFVYRVDMRLRPFGDSGPLVLSFAALEDYYQEQGRDWERYAMVKARLMGGADDPYSQELRQMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLKDNIKLGAGGIREIEFITQVFQLIRGGREPRLQERALLPTLQAVAELGLLPEQQVADLSGSYLFLRRLENLLQAIADEQTQTLPNDPLNQARLAWGMGYADWAAMSTALENHMQAVRVVFDDLIGDETPDIGEDPSHGLYKSLWQDVLEESDLAPLTPHLEEAARRQLLATISGFRHDVDKRTIGPRGREVLDQLMPRLFAEVCPRPDANVALSRLILLLLSIVTRTTYLELLVEYHAALKHVIRLCSASPMVASQLARYPLLLDELLDPQSLYQPLAPSAYRDELRQYLLRVPEDDEEQQLEALRQFKQAQQLRIAAGDITEALPVMKVSDHLTYLAEAIIDAVIQQAWNQMVARYGQPSHLQQSEGRGFAVIGYGKLGGWELGYSSDLDLVFLLDCPLDVMTDGDRSIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGEAGMLVSTIEAFADYQRNEAWTWEHQALVRARIVYGSPKLHQQFDAIRQQILCRHREDPQLQQEVREMREKMRNHLGSKQRDIFDIKADAGGITDIEFIAQYLVLRYAASEPRLTRWSDNVRIFESMAHYDIMSPEEAAALTRAYVTMRDEIHHLALQEQSSKVAADSFIAEREQVAASWHKWLAANDANVS

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

951 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

107.918 kDa

MSILPLPALPVLLTEQSQRALSRLREAAPDEPITDSDSAVLALSDFVSDALALHPDWWQGIHQQPPQPEEWQHYADWLSNALVDVNDENALMAALRRFRRHMLARIAWSQALQTSTTEHSLRQLSELAEVIIVAARSWLYQVCCHEWGTPCNAKGVAQPLLILGMGKLGGGELNFSSDIDLIFVYPENGHTQGGRRELDNAQFFTRLGQRLIKVLDQPTVDGFVYRVDMRLRPFGDSGPLVLSFAAMEDYYQEQGRDWERYAMVKARLMGGMDDAYSQELRSTLKPFVFRRYIDFSVIQSLRNMKGMIAREVRRRDLRNNIKLGAGGIREIEFITQVFQLIRGGREPGLQGRSLLPTLQHVGALGLLTPQQVLDLSTSYLFLRRLENLLQAIADEQTQTLPSDELNQQRLAWGMGFDSWDTLQSMLSQHMQAVRHVFDELIGDDAPDNNDIPEHSSYSSLWQDTLDDGDLAPLTPHLTETVREKLMRTIVEFRNDVAKRTIGPRGRDVLDQLMPCLLAEVCARQEADTVLSRLTPLLLGIVTRTTYLELLLESRAALAQLIRLCAASPMVASQLARYPLLLDELLDASTLYQPTAPGAYADELRQYLMRVPEDDEEQQLEAVRQFKQSQQLRIAAGDIGGVLPVMKVSDHLTYLAEAIIAAVVQQAWGLMVERYGQPSHLQHREGRGFAVIAYGKLGGWELGYSSDLDLVFLLDCPSDVMTDGERSIDGRQFYLRLAQRVMHLFSTRTSSGILYEVDARLRPSGAAGMLVSTVEAFDDYQRNEAWTWEHQALVRARMVYGESGVQQTFESIRRSILCAERDADTLRTEVREMREKMRQHLANKDKSRFDIKTDAGGITDIEFITQYLVLRYAAQEPRLTHWSDNVRILELMAQYGVMEESEANALKLAYVTMRNELHHLALQELSGRVSKDRFVAEREQVLVSWNKWLMGA

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

951 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.32 kDa

MLPLPSELQIQAQSIKQRFSELPAPPDLRDEDIAVLALSDFVSDMLLIHPQWLEELHQQPPQPQEWQYYSQWLSQALAGVQDEAALLTALRLFRRRVMVRIAWSQVLQTSGTAETLQQLSTLAESMIIAARDWLYQVCCRELGTPCNRQGVPQPLLILGMGKLGGGELNFSSDIDLIFAYPENGQTQGGRRELDNAQFFTRLGQRLIKALDQHTIDGFVYRVDMRLRPFGDSGPLVLSFAALEDYYQEQGRDWERYAMVKARLMGGADDPYSQELRQMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLKDNIKLGAGGIREIEFITQVFQLIRGGREPRLQERALLPTLQAVAELGLLPEQQVADLSGSYLFLRRLENLLQAIADEQTQTLPNDPLNQARLAWGMGYADWAAMSTALENHMQAVRVVFDDLIGDETPDIGEDPSHGLYKSLWQDVLEESDLAPLTPHLEEAARRQLLATISGFRHDVDKRTIGPRGREVLDQLMPRLFAEVCSRPDANVALSRLILLLLSIVTRTTYLELLVEYHAALKHVIRLCSASPMVASQLARYPLLLDELLDPQSLYQPLAPSAYRDELRQYLLRVPEDDEEQQLEALRQFKQAQQLRIAAGDITEALPVMKVSDHLTYLAEAIIDAVIQQAWNQMVARYGQPSHLQQSEGRGFAVIGYGKLGGWELGYSSDLDLVFLLDCPLDVMTDGDRSIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGEAGMLVSTIEAFADYQRNEAWTWEHQALVRARIVYGSPKLHQQFDAIRQQILCRHREDPQLQQEVREMREKMRNHLGSKQRDIFDIKADAGGITDIEFIAQYLVLRYAASEPRLTRWSDNVRIFESMAHYDIMSPEEAAALTRAYVTMRDEIHHLALQEQSSKVAADSFIAEREQVAASWHKWLAANDANVS

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

951 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.33 kDa

MLPLPSELQIQAQSIKQRFSELPAPPDLRDEDIAVLALSDFVSDMLLIHPQWLEELHQQPPQPQEWQYYSQWLSQALAGVQDEAALLTALRLFRRRVMVRIAWSQVLQTSGTAETLQQLSTLAESMIIAARDWLYQVCCRELGTPCNRQGVPQPLLILGMGKLGGGELNFSSDIDLIFAYPENGQTQGGRRELDNAQFFTRLGQRLIKALDQHTIDGFVYRVDMRLRPFGDSGPLVLSFAALEDYYQEQGRDWERYAMVKARLMGGADDPYSQELRQMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLKDNIKLGAGGIREIEFITQVFQLIRGGREPRLQERALLPTLQAVAELGLLPEQQVADLSGSYLFLRRLENLLQAIADEQTQTLPNDPLNQARLAWGMGYADWAAMSTALENHMQAVRVVFDDLIGDETPDIGEDPSHGLYKSLWQDVLEESDLAPLTPHLEEAARRQLLATISGFRHDVDKRTIGPRGREVLDQLMPRLFAEVCPRPDANVALSRLILLLLSIVTRTTYLELLVEYHAALKHVIRLCSASPMVASQLARYPLLLDELLDPQSLYQPLAPSAYRDELRQYLLRVPEDDEEQQLEALRQFKQAQQLRIAAGDITEALPVMKVSDHLTYLAEAIIDAVIQQAWNQMVARYGQPSHLQQSEGRGFAVIGYGKLGGWELGYSSDLDLVFLLDCPLDVMTDGDRSIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGEAGMLVSTIEAFADYQRNEAWTWEHQALVRARIVYGSPKLHQQFDAIRQQILCRHREDPQLQQEVREMREKMRNHLGSKQRDIFDIKADAGGITDIEFIAQYLVLRYAASEPRLTRWSDNVRIFESMAHYDIMSPEEAAALTRAYVTMRDEIHHLALQEQSSKVAADSFIAEREQVAASWHKWLAANDANVS

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

951 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.33 kDa

MLPLPSELQIQAQSIKQRFSELPAPPDLRDEDIAVLALSDFVSDMLLIHPQWLEELHQQPPQPQEWQYYSQWLSQALAGVQDEAALLTALRLFRRRVMVRIAWSQVLQTSGTAETLQQLSTLAESMIIAARDWLYQVCCRELGTPCNRQGVPQPLLILGMGKLGGGELNFSSDIDLIFAYPENGQTQGGRRELDNAQFFTRLGQRLIKALDQHTIDGFVYRVDMRLRPFGDSGPLVLSFAALEDYYQEQGRDWERYAMVKARLMGGADDPYSQELRQMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLKDNIKLGAGGIREIEFITQVFQLIRGGREPRLQERALLPTLQAVAELGLLPEQQVADLSGSYLFLRRLENLLQAIADEQTQTLPNDPLNQARLAWGMGYADWAAMSTALENHMQAVRVVFDDLIGDETPDIGEDPSHGLYKSLWQDVLEESDLAPLTPHLEEAARRQLLATISGFRHDVDKRTIGPRGREVLDQLMPRLFAEVCPRPDANVALSRLILLLLSIVTRTTYLELLVEYHAALKHVIRLCSASPMVASQLARYPLLLDELLDPQSLYQPLAPSAYRDELRQYLLRVPEDDEEQQLEALRQFKQAQQLRIAAGDITEALPVMKVSDHLTYLAEAIIDAVIQQAWNQMVARYGQPSHLQQSEGRGFAVIGYGKLGGWELGYSSDLDLVFLLDCPLDVMTDGDRSIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGEAGMLVSTIEAFADYQRNEAWTWEHQALVRARIVYGSPKLHQQFDAIRQQILCRHREDPQLQQEVREMREKMRNHLGSKQRDIFDIKADAGGITDIEFIAQYLVLRYAASEPRLTRWSDNVRIFESMAHYDIMSPEEAAALTRAYVTMRDEIHHLALQEQSSKVAADSFIAEREQVAASWHKWLAANDANVS

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

951 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.33 kDa

MLPLPSELQIQAQSIKQRFSELPAPPDLRDEDIAVLALSDFVSDMLLIHPQWLEELHQQPPQPQEWQYYSQWLSQALAGVQDEAALLTALRLFRRRVMVRIAWSQVLQTSGTAETLQQLSTLAESMIIAARDWLYQVCCRELGTPCNRQGVPQPLLILGMGKLGGGELNFSSDIDLIFAYPENGQTQGGRRELDNAQFFTRLGQRLIKALDQHTIDGFVYRVDMRLRPFGDSGPLVLSFAALEDYYQEQGRDWERYAMVKARLMGGADDPYSQELRQMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLKDNIKLGAGGIREIEFITQVFQLIRGGREPRLQERALLPTLQAVAELGLLPEQQVADLSGSYLFLRRLENLLQAIADEQTQTLPNDPLNQARLAWGMGYADWAAMSTALENHMQAVRVVFDDLIGDETPDIGEDPSHGLYKSLWQDVLEESDLAPLTPHLEEAARRQLLATISGFRHDVDKRTIGPRGREVLDQLMPRLFAEVCPRPDANVALSRLILLLLSIVTRTTYLELLVEYHAALKHVIRLCSASPMVASQLARYPLLLDELLDPQSLYQPLAPSAYRDELRQYLLRVPEDDEEQQLEALRQFKQAQQLRIAAGDITEALPVMKVSDHLTYLAEAIIDAVIQQAWNQMVARYGQPSHLQQSEGRGFAVIGYGKLGGWELGYSSDLDLVFLLDCPLDVMTDGDRSIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGEAGMLVSTIEAFADYQRNEAWTWEHQALVRARIVYGSPKLHQQFDAIRQQILCRHREDPQLQQEVREMREKMRNHLGSKQRDIFDIKADAGGITDIEFIAQYLVLRYAASEPRLTRWSDNVRIFESMAHYDIMSPEEAAALTRAYVTMRDEIHHLALQEQSSKVAADSFIAEREQVAASWHKWLAANDANVS

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

951 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.33 kDa

MLPLPSELQIQAQSIKQRFSELPAPPDLRDEDIAVLALSDFVSDMLLIHPQWLEELHQQPPQPQEWQYYSQWLSQALAGVQDEAALLTALRLFRRRVMVRIAWSQVLQTSGTAETLQQLSTLAESMIIAARDWLYQVCCRELGTPCNRQGVPQPLLILGMGKLGGGELNFSSDIDLIFAYPENGQTQGGRRELDNAQFFTRLGQRLIKALDQHTIDGFVYRVDMRLRPFGDSGPLVLSFAALEDYYQEQGRDWERYAMVKARLMGGADDPYSQELRQMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLKDNIKLGAGGIREIEFITQVFQLIRGGREPRLQERALLPTLQAVAELGLLPEQQVADLSGSYLFLRRLENLLQAIADEQTQTLPNDPLNQARLAWGMGYADWAAMSTALENHMQAVRVVFDDLIGDETPDIGEDPSHGLYKSLWQDVLEESDLAPLTPHLEEAARRQLLATISGFRHDVDKRTIGPRGREVLDQLMPRLFAEVCPRPDANVALSRLILLLLSIVTRTTYLELLVEYHAALKHVIRLCSASPMVASQLARYPLLLDELLDPQSLYQPLAPSAYRDELRQYLLRVPEDDEEQQLEALRQFKQAQQLRIAAGDITEALPVMKVSDHLTYLAEAIIDAVIQQAWNQMVARYGQPSHLQQSEGRGFAVIGYGKLGGWELGYSSDLDLVFLLDCPLDVMTDGDRSIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGEAGMLVSTIEAFADYQRNEAWTWEHQALVRARIVYGSPKLHQQFDAIRQQILCRHREDPQLQQEVREMREKMRNHLGSKQRDIFDIKADAGGITDIEFIAQYLVLRYAASEPRLTRWSDNVRIFESMAHYDIMSPEEAAALTRAYVTMRDEIHHLALQEQSSKVAADSFIAEREQVAASWHKWLAANDANVS

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

951 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.33 kDa

MLPLPSELQIQAQSIKQRFSELPAPPDLRDEDIAVLALSDFVSDMLLIHPQWLEELHQQPPQPQEWQYYSQWLSQALAGVQDEAALLTALRLFRRRVMVRIAWSQVLQTSGTAETLQQLSTLAESMIIAARDWLYQVCCRELGTPCNRQGVPQPLLILGMGKLGGGELNFSSDIDLIFAYPENGQTQGGRRELDNAQFFTRLGQRLIKALDQHTIDGFVYRVDMRLRPFGDSGPLVLSFAALEDYYQEQGRDWERYAMVKARLMGGADDPYSQELRQMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLKDNIKLGAGGIREIEFITQVFQLIRGGREPRLQERALLPTLQAVAELGLLPEQQVADLSGSYLFLRRLENLLQAIADEQTQTLPNDPLNQARLAWGMGYADWAAMSTALENHMQAVRVVFDDLIGDETPDIGEDPSHGLYKSLWQDVLEESDLAPLTPHLEEAARRQLLATISGFRHDVDKRTIGPRGREVLDQLMPRLFAEVCPRPDANVALSRLILLLLSIVTRTTYLELLVEYHAALKHVIRLCSASPMVASQLARYPLLLDELLDPQSLYQPLAPSAYRDELRQYLLRVPEDDEEQQLEALRQFKQAQQLRIAAGDITEALPVMKVSDHLTYLAEAIIDAVIQQAWNQMVARYGQPSHLQQSEGRGFAVIGYGKLGGWELGYSSDLDLVFLLDCPLDVMTDGDRSIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGEAGMLVSTIEAFADYQRNEAWTWEHQALVRARIVYGSPKLHQQFDAIRQQILCRHREDPQLQQEVREMREKMRNHLGSKQRDIFDIKADAGGITDIEFIAQYLVLRYAASEPRLTRWSDNVRIFESMAHYDIMSPEEAAALTRAYVTMRDEIHHLALQEQSSKVAADSFIAEREQVAASWHKWLAANDANVS

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

951 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.33 kDa

MLPLPSELQIQAQSIKQRFSELPAPPDLRDEDIAVLALSDFVSDMLLIHPQWLEELHQQPPQPQEWQYYSQWLSQALAGVQDEAALLTALRLFRRRVMVRIAWSQVLQTSGTAETLQQLSTLAESMIIAARDWLYQVCCRELGTPCNRQGVPQPLLILGMGKLGGGELNFSSDIDLIFAYPENGQTQGGRRELDNAQFFTRLGQRLIKALDQHTIDGFVYRVDMRLRPFGDSGPLVLSFAALEDYYQEQGRDWERYAMVKARLMGGADDPYSQELRQMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLKDNIKLGAGGIREIEFITQVFQLIRGGREPRLQERALLPTLQAVAELGLLPEQQVADLSGSYLFLRRLENLLQAIADEQTQTLPNDPLNQARLAWGMGYADWAAMSTALENHMQAVRVVFDDLIGDETPDIGEDPSHGLYKSLWQDVLEESDLAPLTPHLEEAARRQLLATISGFRHDVDKRTIGPRGREVLDQLMPRLFAEVCPRPDANVALSRLILLLLSIVTRTTYLELLVEYHAALKHVIRLCSASPMVASQLARYPLLLDELLDPQSLYQPLAPSAYRDELRQYLLRVPEDDEEQQLEALRQFKQAQQLRIAAGDITEALPVMKVSDHLTYLAEAIIDAVIQQAWNQMVARYGQPSHLQQSEGRGFAVIGYGKLGGWELGYSSDLDLVFLLDCPLDVMTDGDRSIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGEAGMLVSTIEAFADYQRNEAWTWEHQALVRARIVYGSPKLHQQFDAIRQQILCRHREDPQLQQEVREMREKMRNHLGSKQRDIFDIKADAGGITDIEFIAQYLVLRYAASEPRLTRWSDNVRIFESMAHYDIMSPEEAAALTRAYVTMRDEIHHLALQEQSSKVAADSFIAEREQVAASWHKWLAANDANVS

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

950 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

109.007 kDa

MSLPSPLIPVAELAMQNAQQSGYLEHWPQALITQFQFISGLSKFVVETVQRDAQLAESLPEMLAQESRQEAYRTRLAEQLQACHDEVAGHRVLRQFRNREMVYIAWKDFTQAWSLEESLSHLSELAEAMIFETYQWQYQLCCKEWGTPTNAQGEAQPMLIIGMGKLGGGELNFSSDIDLIFTYPENGETQGARRSIANAQFFTRLGQRLIKALDQQTFDGFCYRVDMRLRPFGESGPLVMSYAALEDYYQEQGRDWERYAMIKARVMGREMYPEYQELRQMLRPFVFRRYIDFSAIQSLRRMKSMISSEVRRRGLSNNIKLGAGGIREIEFIAQVFQLIRGGREPALRQRGLLVTLEAIKQLQLLEEAQVCHLVEAYKYLRRLENLLQAMADKQTQTLPDNELEQLALAVAMGYSQWQALQNDVQQHMAKVHAVFVTLIGDEEDEVSPVERHFNELWDMAHNPEVIEQILQNDLACQNAATMSEQIIQFKADLAKKTLGPRGREVLNRLMPKLFSAIFADADAQFGLPRVLHLLHNIATRTTYLELLDEHPAALTQLVRLCTASPMISEQLARYPILLDELIDPQQLYNPIALDAYRTELRDFLARIPEDDVEQQMDALRQFKQICSLRIAAADIAGVLPVMKVSDHLTYLAEAIVEAVVHQAWQQVAEKYGEPTHLKDREGKGFAVVGYGKVGGWELGYNSDLDVVFLHDCPVNVYTDGKKEIDGRQFYLRLAQRIIHIFSTRTASGILYEVDTRLRPSGASGLLVCPVDAFEEYQHNDAWTWEHQALVRARMIYGDEHLASEFHRVRHQVLAKPREQAKLQKEVADMRAKMRDHLGGKKSDRFMLKQDQGGITDIEFLAQYLVLNYSAEKPKLTRWCDNVRIFETLIAQGVMEEAQAMLLTQAYTTMRDEIHRRNLLNLDADVALDKFVALRQGVSKAWQEWLESSTI

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

950 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.919 kDa

MSLPSPLLPVAELAMQNAQQSGYLEHWPQALITQFQFISGLSKFVVETVQRDAQLAEGLPEMLAQESRQEAYRTRLAEQLQACHDEVAGHRVLRQFRNREMVYIAWKDFTQAWSLEASLSHLSELAEAMIFETYQWQYQLCCQEWGTPTNAQGEAQPMLIIGMGKLGGGELNFSSDIDLIFTYPENGETQGARRSIANAQFFTRLGQRLIKALDQQTFDGFCYRVDMRLRPFGESGPLVMSYAALEDYYQEQGRDWERYAMIKARVMGREMYPEYQELRQMLRPFVFRRYIDFSAIQSLRRMKSMISSEVRRRGLSNNIKLGAGGIREIEFIAQVFQLIRGGREPALRQRGLLVTLEAIKQLQLLEEAQVCHLVEAYKYLRRLENLLQAMADKQTQTLPDNELEQLALAVAMGYSQWQALQNDVQQHMAKVHAVFVTLIGDEEDEVSPVERHFNELWDMAHNPEVIEQILQNDLACQNAATMSEQIIQFKADLAKKTLGPRGREVLNRLMPKLFSAIFADADAQFGLPRVLHLLHNIATRTTYLELLDEHPAALTQLVRLCTASPMISEQLARYPILLDELIDPQQLYNPIALDAYRTELRDFLARIPEDDVEQQMDALRQFKQICSLRIAAADIAGVLPVMKVSDHLTYLAEAIVEAVVHQAWQQVAEKYGEPTHLKDREGKGFAVVGYGKVGGWELGYNSDLDVVFLHDCPVNVYTDGKKEIDGRQFYLRLAQRIIHIFSTRTASGILYEVDTRLRPSGASGLLVCPVDAFEEYQHNDAWTWEHQALVRARMIYGDEHLASEFHRVRHQVLAKPREQAKLQKEVADMRAKMRDHLGGKKSDRFMLKQDQGGITDIEFLAQYLVLNYSAEKPKLTRWCDNVRIFETLIAQGVMEEAQAMLLTQAYTTMRDEIHRRNLLNLDADVALDKFVALRQGVSKAWQEWLESSTI

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

950 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.452 kDa

MLPLPSELQIQAQNIQQRFYELPAPLSLREEDIAVLVLSDFVSDMLLIHPDWLDELHQQPPQPQEWQFYQQWLSQALAEVQDEAALLAALRLFRRRIMVRIAWSQALETSSTTDTLQQLSWLAESLIIAARDWLYQACCREFGTPCNSEGVPQPLLILGMGKLGGGELNFSSDIDLIFAYPENGQTQGGRRQLDNAQFFTRLGQRLIKALDQQTIDGFVYRVDMRLRPFGDSGPLVLSFAALEDYYQEQGRDWERYAMVKARLMGGAEDHYSKELRQTLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLKDNIKLGAGGIREIEFITQVFQLIRGGREPRLQERALLPTLQAVAELGLLPEQQVADLSGSYLFLRRLENLLQAIADEQTQTLPSDSLNQARLACGMGYVDWVAMNAALEQHMQAVRLVFDHLIGDDAPDIGEDPSHGLYKSLWQDVLEEGDLAPLTPHLDEAARSQLLVTINHFRHDVDKRTIGPRGREVLDQLMPRLFAEVCPRPDANVALSRLIQLLLSIVTRTTYLELLVEYHAALKHVIRLCSASPMVASQLARYPLLLDELLDPQSLYQPLEPSAYRDELRQYLLRVPPDDEEQQLEALRQFKQAQQLRIAAGDITEALPVMKVSDHLTYLAEAMIDAVIQQAWNQMVARYGQPSHLQQREGRGFAVIGYGKLGGWELGYSSDLDLVFLLDCPLDVMTDGERSIDGRQFYLRLAQRVMHLFSTRTSSGILYEVDARLRPSGEAGMLVSTIEAFADYQQNEAWTWEHQALVRARIVYGCPELQQKFDAIRQQILCRSREGSQLQQEVREMREKMRNHLGSKQRDIFDIKADEGGITDIEFIAQYLVLRYAATEPRLTRWSDNVRIFELMANYDIMPEAEAAALTRAYVTMRDEIHHLALQEQSSKVSADCFAAEREQVAASWHKWLVAAPSDV

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

949 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.507 kDa

MQNQGNKVLSAAMLDSADRYWLRLCDVWPEAKTALTAMQQQELTAVFGLSDYMGEQLCRHPEWIVQLFDGLLDDVVRSEFDAQLHSLIADLTQEELVKSALRRYRNLQMVRLAWRDFLNYTPVEESLLDLSALAEALVIAGRDWLYQEMCQQYGTPTSAEGNPQPLLILGMGKLGGRELNFSSDIDLIFTFPEHGETVGGRRTQANQQFFIRMGQRLVNLLDQVTVDGFVFRVDMRLRPYGESGPLVVSFSGLEDYYQEQGRDWERYAMVKARVLGPWSGYCDELHDLLRPFVYRRYIDFSAIESLRKMKQLIAQEVRRRQLTDNIKLGAGGIREVEFVVQSFQLIRGGREPALRQQSLFGAIDTLYSLGQLEYLAVDELKHSYIILRRVENLLQAIDDKQTQTLPNNELDWQRLCYPLDMADEVELRQKINQAMVTIHGHFNATVGGTDSHEHNDHWTALFWNVQQDEHANALLQEQQVDDAELWQLLSEWRQTVSKRSIGPRGRETLDKLMPKLLEELVTQTKPSQAFKPVAKVLDKILTRTTYLELLCENPGARQQLVSLCCASPWIARELANFPMLLDELIDPSQLYDITSIDDYPSELRQYLLRVPEDDMEQQMEALRQFKLSQQLKIAAADVTGVLPVMQVSDHLTFLAEAIIEQVVLQAWHQVASRHGIPAETSPSNMGFAVIGYGKLGGIELGYGSDLDLVFLHGHTGSGTTDGKRPIDNGHFYLKLAQRIVHLFATRTTSGELYEVDMRLRPSGASGLLVSEIEHFGAYLQQEAWTWEHQALVRSRFVFGDYSLAGRFSDLRAQVLKIERDKQVLAKAVKDMRIKMREHLLQVEPGQFDLKQSAGGIADIEFIAQYLVLANAHQYHELTIWSDNVRIFEVLAELELLPIMQAQHLTQTYCWLRDENHELTLQQLPGKLPIQSVLQKTDSVIEIYNEILAI

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

948 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.663 kDa

MLTPDNKLMSETETAWERYKEVVESITLTAEQEQILRALFAVSPFIGRVAESYPEHLVTDFFDGSGSSVRLIDADSYGDRIAESLSQVTNEDEAKKCLRRLRHCWMAKLAAADILQQVSLKESLHHYSTFADAAINKSLEWLFERFVQRHGKPLDANDQLMPMLVIGMGKLGGKELNFSSDIDLIFAFPEQGETQGPGRNLEHGVFYKRLAQSLIGLLDETTADGQVFRVDMRLRPFGQSGPLVTSLNALEHYYQEQGRDWERYAMVKARMIGADEQYEQAFQQLIRPFVYRRYIDFGAIEALRKMKLLITQETRRQGVKNNIKLGAGGIREVEFIVQAHQLIRGGQEKSLQTRSVYIAMNGLVELDLIDPEHARQLLKDYEYLRVIEHRLQQIDDQQTQQLPTDETGRMRLCAMLNEPEWETLQRKIDECMERIHAEFQQVVGAESEDDEDEQGLQVLWQDMLDDDAALEIIESEGVDEPQALWTLIKNFRQESRRRSSGPRGRSALARLMPIMLRHAIQHQHPERLLERLLSIIKAVMSRTAYIELLAENPGAREQLCKLCMASPWISEQLALHPILLDELIDPQQLYSLPESKDYAAVLREYLMRIPEQDLETQMDALRQAKQALQLKIAAADISGVLELMNVSDHLSALAEAIISEVVGLAWQHLTQKHGKPAGTCLDNTGFAVLGYGKLGGQELGYGSDLDLVFVTDANYQGQTDGQRPIEVQQFYLRLAQRILHLFTTRTVAGILYDVDLRLRPSGQAGLLVTQVNSFARYLRDDAWTWELQALVRARPVYGVPALRDTVMDIRRSVLSQKRDEQELRQSIVKMREKMREHLTQRNSRKFDLKQDPGGIADIEFITQYLVLRYAHKYPELCKYSDNVRLLTEAQQLHLLTEVDAQNLINAFQIFRCESHSLALQGEQLLEEHNLDNERQAVLNCWNHLLEDD

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

948 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

106.527 kDa

MAPPPDTSGSCSAFHECERIFAQWGYPFQDYSESFRQSLDTVCRCSRFFLGVVKRDAHVIPLLASLFEGQTPERNPSADLQQRVAEVADRNGLMRVLRQWRNREMAIIAWQDICGLLDIDSVLTRISETAESAIRTALDWLFDDACRRWGVPRRKDGSAQSLVVLGMGKLGGYELNFSSDIDLVFAYVEDGELPGRNGATYAEFYTRLAQSLVHVLDAVTEDGFVFRVDVRLRPFGESGPLVVSFDSCERYYQAQARDWERYAMVKVRAVGGDAKDGREFERFFHPFVYRRYLDYRVFGELRSLKARIMAELRRKDRGDNIKLGAGGIREIEFIGQAFQLIRGGRNVELQDRRILVVLERLGRLRLLEHGTASFLCAAYRFLRKVENRLQQYEDKQTHELPVSEERRGLLAFSMGFESWEGFLHRLDEVRRRVHEIFTEVIAEPPQPARGEPLLDGGEAELSQALAGFDGAAEAMTGALVKFRASAPVRRLGAGARAELQRVIGKLLAELAAFRVSDPVGVLGRILELFESIAGRGVYFSLLAENPSALSQLVRLAAASPWIVRLIAGAPILLDELLDPRTLYSPLTRESLGREADILFSSLAPDDDEQLMLRLRQFKAAHQLRIAAADIMNVIPVMVVSDYLTDLAEVVIERVLRLAWKFAAARHGIPPVEAETSVDFPGFGIIAYGKLGGIELGYGSDLDLVFLYDGVASDAVTDGPRPISAAEFYARVVQRMVSLLTADMPGGALYEVDLRLRPSGSSGLLVSKADAYENYQLHQAWTWERQALVRARFVAGDPKVGARFDAIRRNVLCRERDSRQVRLDVRSMREKMREHLADRRPGVFDLKQGVGGIADIEFIVQFGVLISAAKHCEITRWTDTVRLLDSLRAINFLELGQADRLRCAYCDYRGRVHRLALQEMPALAASSEFPGHRTAVEAVWKQIIEAPVF

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

948 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.663 kDa

MLTPDNKLMSETETAWERYKEVVESITLTAEQEQILRALFAVSPFIGRVAESYPEHLVTDFFDGSGSSVRLIDADSYGDRIAESLSQVTNEDEAKKCLRRLRHCWMAKLAAADILQQVSLKESLHHYSTFADAAINKSLEWLFERFVQRHGKPLDANDQLMPMLVIGMGKLGGKELNFSSDIDLIFAFPEQGETQGPGRNLEHGVFYKRLAQSLIGLLDETTADGQVFRVDMRLRPFGQSGPLVTSLNALEHYYQEQGRDWERYAMVKARMIGADEQYEQAFQQLIRPFVYRRYIDFGAIEALRKMKLLITQETRRQGVKNNIKLGAGGIREVEFIVQAHQLIRGGQEKSLQTRSVYIAMNGLVELDLIDPEHARQLLKDYEYLRVIEHRLQQIDDQQTQQLPTDETGRMRLCAMLNEPEWETLQRKIDECMERIHAEFQQVVGAESEDDEDEQGLQVLWQDMLDDDAALEIIESEGVDEPQALWTLIKNFRQESRRRSSGPRGRSALARLMPIMLRHAIQHQHPERLLERLLSIIKAVMSRTAYIELLAENPGAREQLCKLCMASPWISEQLALHPILLDELIDPQQLYSLPESKDYAAVLREYLMRIPEQDLETQMDALRQAKQALQLKIAAADISGVLELMNVSDHLSALAEAIISEVVGLAWQHLTQKHGKPAGTCLDNTGFAVLGYGKLGGQELGYGSDLDLVFVTDANYQGQTDGQRPIEVQQFYLRLAQRILHLFTTRTVAGILYDVDLRLRPSGQAGLLVTQVNSFARYLRDDAWTWELQALVRARPVYGVPALRDTVMDIRRSVLSQKRDEQELRQSIVKMREKMREHLTQRNSRKFDLKQDPGGIADIEFITQYLVLRYAHKYPELCKYSDNVRLLTEAQQLHLLTEVDAQNLINAFQIFRCESHSLALQGEQLLEEHNLDNERQAVLNCWNHLLEDD

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

948 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

106.527 kDa

MAPPPDTSGSCSAFHECERIFAQWGYPFQDYSESFRQSLDTVCRCSRFFLGVVKRDAHVIPLLASLFEGQTPERNPSADLQQRVAEVADRNGLMRVLRQWRNREMAIIAWQDICGLLDIDSVLTRISETAESAIRTALDWLFDDACRRWGVPRRKDGSAQSLVVLGMGKLGGYELNFSSDIDLVFAYVEDGELPGRNGATYAEFYTRLAQSLVHVLDAVTEDGFVFRVDVRLRPFGESGPLVVSFDSCERYYQAQARDWERYAMVKVRAVGGDAKDGREFERFFHPFVYRRYLDYRVFGELRSLKARIMAELRRKDRGDNIKLGAGGIREIEFIGQAFQLIRGGRNVELQDRRILVVLERLGRLRLLEHGTASFLCAAYRFLRKVENRLQQYEDKQTHELPVSEERRGLLAFSMGFESWEGFLHRLDEVRRRVHEIFTEVIAEPPQPARGEPLLDGGEAELSQALAGFDGAAEAMTGALVKFRASAPVRRLGAGARAELQRVIGKLLAELAAFRVSDPVGVLGRILELFESIAGRGVYFSLLAENPSALSQLVRLAAASPWIVRLIAGAPILLDELLDPRTLYSPLTRESLGREADILFSSLAPDDDEQLMLRLRQFKAAHQLRIAAADIMNVIPVMVVSDYLTDLAEVVIERVLRLAWKFAAARHGIPPVEAETSVDFPGFGIIAYGKLGGIELGYGSDLDLVFLYDGVASDAVTDGPRPISAAEFYARVVQRMVSLLTADMPGGALYEVDLRLRPSGSSGLLVSKADAYENYQLHQAWTWERQALVRARFVAGDPKVGARFDAIRRNVLCRERDSRQVRLDVRSMREKMREHLADRRPGVFDLKQGVGGIADIEFIVQFGVLISAAKHCEITRWTDTVRLLDSLRAINFLELGQADRLRCAYCDYRGRVHRLALQEMPALAASSEFPGHRTAVEAVWKQIIEAPVF

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

948 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

109.334 kDa

MSLPSALLPTAELHYQSLISEHPHIANWPSSVLNQLRYVLGLSQFVAQTLQRDDPLCQVLPSLLAKPSREQYYRSELAQWLAECQDEAVAQKRLRQFRNQEMVYIAWRDFCASWTLEESLSHLSQLAEALIFESYQWLYQRCCLEMGTPCNAQGEAQPMLIIGMGKLGGGELNFSSDIDLIFTYPENGETQGARRSIANAQFFTRLGQRLIKLLDQSTPDGFCYRVDMRLRPFGDSGPLAMSYAALEDYYQEQGRDWERYAMIKARVMGREMYPQYQELRQMLRPFVFRRYIDFSAIQSLRRMKSMISSEVRRRGLSNNIKLGAGGIREVEFIAQVFQLIRGGREPSLRKRGLLETLDAIAELELLTREQVQDLRDAYRFLRRLENLLQAMADKQTQTLPDKEDDQLRLSIAIGLADWPSLQREVSEHMQRVHRVFATLIGEEDEEEEHTVARHFHELWDMAHKPEVIEHIIEQDLGLSDAGEQIRTITQFKDDLAKRTIGPRGREVLNRLMPKVYQAVFAHPDAEFGLSRVLALLHSIATRTTYLELLDEHPAALVQLVRLCTASPMISEQLARYPILLDELIDPQHLYNPIPLESYQTELRDFLARIPEEDMEQQMEGLRQFKQISILRIAAADIAGVLPVMKVSDHLTYLAEAIVEAVVSQAWLQVSSKYGEPTHLKHRDGRGFAVVGYGKVGGWELGYNSDLDIVFMHDCPVEVNTDGEKSIDGRQFYLRLAQRIIHIFSTRTASGILYEVDTRLRPSGASGLLVSPTDAFDEYQRQEAWTWEHQALVRARMIYGDAPLQQAFANTRHQILCLPREEHKLKQEVVEMRIKMRDHLGGKKAGRFMLKQDEGGITDIEFLAQYLVLRFSHQQPKLTRWSDNVRIFESLMNHQVMSESQALALTHAYTSMRDQIHRRNLLNQSADVRDSQFVVEREQVIQAWQQWLG

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

947 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.023 kDa

MTPLSSPLSQYWQTVVERLPEGFTETSLSVQAKSVLTFSDFALDSVIAHPEWLAELESASPQADEWRHYAGWLQEALAGVCDDASLMRELRFFRRRIMVRIAWAQTLSLVDDETILQQLSHLAETLIVGARDWLYAACCREWGTPCNPQGVPQPLLILGMGKLGGGELNFSSDIDLIFAWPEHGETRGGRRELDNAQFFTRLGQRLIKALDQPTMDGFVYRVDMRLRPFGDSGPLVLSFAALEDYYQEQGRDWERYAMVKARLMGDNDDAWSRELRAMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLKDNIKLGAGGIREIEFIVQVFQLIRGGREPSLQSRSLLPTLDAIAALHLLPENDVAQLRVAYLFLRRLENLLQSINDEQTQTLPADDLNRARLAWGMKAENWPQLVGELTDHMANVRRVFNELIGDDEADTPQEEERSEPWREVWQDALQEDDSTPVLAHLADEDRRQVLTLIADFRKELDKRPIGPRGRQVLDQLMPHLLADVCSREDAAVTLSRITPLLAGIVTRTTYLELLSEFPGALKHLIMLCAASPMIASQLARYPLLLDELLDPGTLYQPTATDAYRDELRQYLLRVPEEDEEQQLEALRQFKQAQLLRIAAADIAGTLPVMKVSDHLTWLAEAMIDAVVQQAWTQMVARYGQPAHLDERQGRGFAVVGYGKLGGWELGYSSDLDLIFLHDCPMDVMTNGEREIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGAAGMLVTSADAFADYQQHEAWTWEHQALVRARVVYGDPQLTSQFDAVRRTIMTTARDGKTLQTEVREMREKMRAHLGNKHRDRFDIKADEGGITDIEFIAQYLVLRYAHEKPKLTRWSDNVRILELLAQNGIMDEHEAQALTVAYTTLRDELHHLALQELPGHVAQTCFSKERALVQASWRKWLVAV

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

947 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

107.909 kDa

MTPLSSPLSQYCQTVVERLPEGFTETSLSAQAKSVLTFSDFALDSVIAHPEWLAELESASPQADEWRHYAGWLQEALAGVCDDASLMRELRLFRRRIMVRIAWAQTLSLVDDETILQQLSHLAETLIVGARDWLYAACCREWGTPCNPQGVPQPLLILGMGKLGGGELNFSSDIDLIFAWPEHGETRGGRRELDNAQFFTRLGQRLIKALDQPTMDGFVYRVDMRLRPFGDSGPLVLSFAALEDYYQEQGRDWERYAMVKARLMGDNDDAWSRELRAMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLKDNIKLGAGGIREIEFIVQVFQLIRGGREPSLQSRSLLPTLDAIAALHLLPENDVAQLRMAYLFLRRLENLLQSINDEQTQTLPADDLNRARLAWGMKAENWPQLVGELTDHMANVRRVFNELIGDDEADTPQEEERSEPWREVWQDALQEDDSTPVLAHLADEDRRQVLTLIADFRKELDKRPIGPRGRQVLDQLMPHLLANVCSREDAAVTLSRITPLLAGIVTRTTYLELLSEFPGALKHLIMLCAASPMIASQLARYPLLLDELLDPGTLYQPTATDAYRDELRQYLLRVPEEDEEQQLEALRQFKQAQLLRIAAADIAGTLPVMKVSDHLTWLAEAMIDAVVQQAWTQMVARYGQPAHLDERQGRGFAVVGYGKLGGWELGYSSDLDLIFLHDCPMDVMTNGEREIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGAAGMLVTSADAFADYQQHEAWTWEHQALVRARVVYGDPQLTSQFDAVRRTIMTTARDGKTLQTEVREMREKMRAHLGNKHRDRFDIKADEGGITDIEFIAQYLVLRYAHEKPKLTRWSDNVRILELLAQNGIMDEHEAQALTVAYTTLRDELHHLALQELPGHVAQTCFSKERALVQASWRKWLVAV

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

947 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

107.961 kDa

MTPLSSPLSQYWQTVVERLPEGFTETSLSAQAKSVLTFSDFALDSVIAHPEWLAELESASPQADEWRHYAGWLQEALAGVCDDASLMRELRLFRRRIMVRIAWAQTLSLVDDETILQQLSHLAETLIVGARDWLYAACCREWGTPCNPQGVPQPLLILGMGKLGGGELNFSSDIDLIFAWPEHGETRGGRRELDNAQFFTRLGQRLIKALDQPTMDGFVYRVDMRLRPFGDSGPLVLSFAALEDYYQEQGRDWERYAMVKARLMGDNDDAWSRELRAMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLKDNIKLGAGGIREIEFIVQVFQLIRGGREPSLQSRSLLPTLDAIAALHLLPENDVAQLRVAYLFLRRLENLLQSINDEQTQTLPADDLNRARLAWGMKAENWPQLVGELTDHMANVRRVFNELIGDDEADTPQEEERSEPWREVWQDALQEDDSTPVLAHLADEDRRQVLTLIADFRKELDKRPIGPRGRQVLDQLMPHLLADVCSREDAAVTLSRITPLLAGIVTRTTYLELLSEFPGALKHLIMLCAASPMIASQLARYPLLLDELLDPGTLYQPTATDAYRDELRQYLLRVPEEDEEQQLEALRQFKQAQLLRIAAADIAGTLPVMKVSDHLTWLAEAMIDAVVQQAWTQMVARYGQPAHLDERQGRGFAVVGYGKLGGWELGYSSDLDLIFLHDCPMDVMTNGEREIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGAAGMLVTSADAFADYQQHEAWTWEHQALVRARVVYGDPQLTSQFDAVRRTIMTTARDGKTLQTEVREMREKMRAHLGNKHRDRFDIKADEGGITDIEFIAQYLVLRYAHEKPKLTRWSDNVRILELLAQNGIMDEHEAQALTVAYTTLRDELHHLALQELPGHVAQTCFSKERALVQASWRKWLVAV

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

947 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

107.961 kDa

MTPLSSPLSQYWQTVVERLPEGFTETSLSAQAKSVLTFSDFALDSVIAHPEWLAELESASPQADEWRHYAGWLQEALAGVCDDASLMRELRLFRRRIMVRIAWAQTLSLVDDETILQQLSHLAETLIVGARDWLYAACCREWGTPCNPQGVPQPLLILGMGKLGGGELNFSSDIDLIFAWPEHGETRGGRRELDNAQFFTRLGQRLIKALDQPTMDGFVYRVDMRLRPFGDSGPLVLSFAALEDYYQEQGRDWERYAMVKARLMGDNDDAWSRELRAMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLKDNIKLGAGGIREIEFIVQVFQLIRGGREPSLQSRSLLPTLDAIAALHLLPENDVAQLRVAYLFLRRLENLLQSINDEQTQTLPADDLNRARLAWGMKAENWPQLVGELTDHMANVRRVFNELIGDDEADTPQEEERSEPWREVWQDALQEDDSTPVLAHLADEDRRQVLTLIADFRKELDKRPIGPRGRQVLDQLMPHLLADVCSREDAAVTLSRITPLLAGIVTRTTYLELLSEFPGALKHLIMLCAASPMIASQLARYPLLLDELLDPGTLYQPTATDAYRDELRQYLLRVPEEDEEQQLEALRQFKQAQLLRIAAADIAGTLPVMKVSDHLTWLAEAMIDAVVQQAWTQMVARYGQPAHLDERQGRGFAVVGYGKLGGWELGYSSDLDLIFLHDCPMDVMTNGEREIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGAAGMLVTSADAFADYQQHEAWTWEHQALVRARVVYGDPQLTSQFDAVRRTIMTTARDGKTLQTEVREMREKMRAHLGNKHRDRFDIKADEGGITDIEFIAQYLVLRYAHEKPKLTRWSDNVRILELLAQNGIMDEHEAQALTVAYTTLRDELHHLALQELPGHVAQTCFSKERALVQASWRKWLVAV

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

947 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.037 kDa

MTPLSSPLSQYWQTVVERLPEGFTETSLSVQAKSVLTFSDFALDSVIAHPEWLAELESASPQADEWRHYAGWLQEALAGVCDDASLMRELRFFRRRIMVRIAWAQTLSLVDDETILQQLSHLAETLIVGARDWLYAACCREWGTPCNPQGVPQPLLILGMGKLGGGELNFSSDIDLIFAWPEHGETRGGRRELDNAQFFTRLGQRLIKALDQPTMDGFVYRVDMRLRPFGDSGPLVLSFAALEDYYQEQGRDWERYAMVKARLMGDNDDAWSRELRAMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLKDNIKLGAGGIREIEFIVQVFQLIRGGREPSLQSRSLLPTLDAIAALHLLPENDVAQLRVAYLFLRRLENLLQSINDEQTQTLPADDLNRARLAWGMKAENWPQLVGELTDHMANVRRVFNELIGDDEADTPQEEERSEPWREVWQDALQEDDSTPVLAHLADEERRQVLTLIADFRKELDKRPIGPRGRQVLDQLMPHLLADVCSREDAAVTLSRITPLLAGIVTRTTYLELLSEFPGALKHLIMLCAASPMIASQLARYPLLLDELLDPGTLYQPTATDAYRDELRQYLLRVPEEDEEQQLEALRQFKQAQLLRIAAADIAGTLPVMKVSDHLTWLAEAMIDAVVQQAWTQMVARYGQPAHLDERQGRGFAVVGYGKLGGWELGYSSDLDLIFLHDCPMDVMTNGEREIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGAAGMLVTSADAFADYQQHEAWTWEHQALVRARVVYGDPQLTSQFDAVRRTIMTTARDGKTLQTEVREMREKMRAHLGNKHRDRFDIKADEGGITDIEFIAQYLVLRYAHEKPKLTRWSDNVRILELLAQNGIMDEHEAQALTVAYTTLRDELHHLALQELPGHVAQTCFSKERALVQASWRKWLVAV

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

947 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.019 kDa

MTPLSSPLSQYWQTVVERLPEGFTETSLSVQAKSVLTFSDFALDSVIAHPEWLAELESASPQADEWRHYAGWLQEALAGVCDDASLMRELRLFRRRIMVRIAWAQTLSLVDDETILQQLSHLAETLIVGARDWLYAACCREWGTPCNPQGVPQPLLILGMGKLGGGELNFSSDIDLIFAWPEHGETRGGRRELDNAQFFTRLGQRLIKALDQPTMDGFVYRVDMRLRPFGDSGPLVLSFAALEDYYQEQGRDWERYAMVKARLMGDNDDAWSRELRAMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLKDNIKLGAGGIREIEFIVQVFQLIRGGREPSLQSRSLLPTLDAIAALHLLPENDVAQLRVAYLFLRRLENLLQSINDEQTQTLPADDLNRARLAWGMKAENWPQLVGELTDHMANVRRVFNELIGDDEADTPQEEERSEPWREVWQDALQEDDSTPVLAHLADEDRRQVLTLIADFRKELDKRPIGPRGRQVLDQLMPHLLADVCSREDAAVTLSRITPLLAGIVTRTTYLELLSEFPGALKHLIMLCAASPMIASQLARYPLLLDELLDPGTLYQPTATDAYRDELRQYLLRVPEEDEEQQLEALRQFKQAQLLRIAAADIAGTLPVMKVSDHLTWLAEAMIDAVVQQAWTQMVARYGQPAHLDERQGRGFAVVGYGKLGGWELGYSSDLDLIFLHDCPMDVMTNGEREIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGAAGMLVTSADAFADYQQHEAWTWEHQALVRARVVYGDPQLTSQFDTVRRTIMTTARDGKTLQTEVREMREKMRAHLGNKHRDRFDIKADEGGITDIEFIAQYLVLRYAHEKPKLTRWSDNVRILELLAQNGIMDEHEAQALTVAYTTLRDELHHLALQELPGHVAQTCFSKERALVQASWRKWLVAV

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

947 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.157 kDa

MTPLSSPLRQYWQTVVERLPEGFTETSLSAQAKSVLTFSDFALDSVIAHPEWLAELESASPQADEWRHYAGWLQEALADVCDDASLMRELRLFRRRIMVRIAWAQALSRVEDETILQQLSHLAETLIVGARDWLYAACCREWGTPCNPQGVPQPLLILGMGKLGGGELNFSSDIDLIFAWPEHGTTQGGRRELDNAQFFTRLGQRLIKALDQPTMDGFVYRVDMRLRPFGDSGPLVLSFAALEDYYQEQGRDWERYAMVKARIMGDNNDAWSRELRAMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLKDNIKLGAGGIREIEFIVQVFQLIRGGREPSLQSRSLLPTLNAITALHLLPENDVTQLRAAYLFLRRLENLLQSINDEQTQTLPADDLNRARLAWGMNTDNWPQLVGKLTEHMANVRRVFNELIGDDEADTPQEEELSEPWREVWQDTLQEGDSTPVLAHLADEDRRQLLTLIADFRKELDKRPIGPRGRQVLDQLMPRLLDDVCSREDAAVTLSRITPLLAGIVTRTTYLELLSEFPGALKHLIMLCAASPMIASQLARYPLLLDELLDPGTLYQPTATNAYRDELRQYLLRVPEEDEEQQLEALRQFKQAQLLRIAAADIAGTLSVMKVSDHLTWLAEAMIDAVVQQAWMQMVARYGQPTHLDERQGRGFAVVGYGKLGGWELGYSSDLDLIFLHDCPIDVMTNGEREIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGAAGMLVTSADAFADYQQHEAWTWEHQALVRARVVYGDPQLTSQFDAVRRTIMTTARDGKTLQTEVREMREKMRSHLGNKHRDRFDIKADEGGITDIEFIAQYLVLRYAHEKPKLTRWSDNVRILELLAQNGIMDEHEAQALTVAYTTLRDELHHLALQELPGHVAQTCFSKERALVQASWRKWLVAV

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

947 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.023 kDa

MTPLSSPLSQYWQTVVERLPEGFTETSLSVQAKSVLTFSDFALDSVIAHPEWLAELESASPQADEWRHYAGWLQEALAGVCDDASLMRELRFFRRRIMVRIAWAQTLSLVDDETILQQLSHLAETLIVGARDWLYAACCREWGTPCNPQGVPQPLLILGMGKLGGGELNFSSDIDLIFAWPEHGETRGGRRELDNAQFFTRLGQRLIKALDQPTMDGFVYRVDMRLRPFGDSGPLVLSFAALEDYYQEQGRDWERYAMVKARLMGDNDDAWSRELRAMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLKDNIKLGAGGIREIEFIVQVFQLIRGGREPSLQSRSLLPTLDAIAALHLLPENDVAQLRVAYLFLRRLENLLQSINDEQTQTLPADDLNRARLAWGMKAENWPQLVGELTDHMANVRRVFNELIGDDEADTPQEEERSEPWREVWQDALQEDDSTPVLAHLADEDRRQVLTLIADFRKELDKRPIGPRGRQVLDQLMPHLLADVCSREDAAVTLSRITPLLAGIVTRTTYLELLSEFPGALKHLIMLCAASPMIASQLARYPLLLDELLDPGTLYQPTATDAYRDELRQYLLRVPEEDEEQQLEALRQFKQAQLLRIAAADIAGTLPVMKVSDHLTWLAEAMIDAVVQQAWTQMVARYGQPAHLDERQGRGFAVVGYGKLGGWELGYSSDLDLIFLHDCPMDVMTNGEREIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGAAGMLVTSADAFADYQQHEAWTWEHQALVRARVVYGDPQLTSQFDAVRRTIMTTARDGKTLQTEVREMREKMRAHLGNKHRDRFDIKADEGGITDIEFIAQYLVLRYAHEKPKLTRWSDNVRILELLAQNGIMDEHEAQALTVAYTTLRDELHHLALQELPGHVAQTCFSKERALVQASWRKWLVAV

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

947 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.039 kDa

MTPLSSPLSQYWQTVVERLPEGFTETSLSVQAKSVLTFSDFALDSVIAHPEWLAELESASPQADEWRHYAGWLQEALAGVCDDASLMRELRFFRRRIMVRIAWAQTLSLVDDETILQQLSHLAETLIVGARDWLYAACCREWGTPCNPQGVPQPLLILGMGKLGGGELNFSSDIDLIFAWPEHGETRGGRRELDNAQFFTRLGQRLIKALDQPTMDGFVYRVDMRLRPFGDSGPLVLSFAALEDYYQEQGRDWERYAMVKARLMGDNDDAWSRELRAMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLKDNIKLGAGGIREIEFIVQVFQLIRGGREPSLQSRSLLPTLDAIAALHLLPENDVAQLRVAYLFLRRLENLLQSINDEQTQTLPADDLNRARLAWGMKAENWPQLVGELTDHMANVRRVFNELIGDDEADTPQEEERSEPWRDVWQDALQEDDSTPVLAHLADEDRRQVLTLIADFRKELDKRPIGPRGRQVLDQLMPHLLADVCSREDAAVTLSRITPLLAGIVTRTTYLELLSEFPGALKHLIMLCAASPMIASQLARYPLLLDELLDPGTLYQPTATDAYRDELRQYLLRVPEEDEEQQLEALRQFKQAQLLRIAAADIAGTLPVMKVSDHLTWLAEAMIDAVVQQAWTQMVARYGQPAHLDERQGRGFAVVGYGKLGGWELGYSSDLDLIFLHDCPMDVMTNGEREIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGAAGMLVTSADAFADYQQHEAWTWEHQALVRARVVYGDPQLTSQFDTVRRTIMTTARDGKTLQTEVREMREKMRAHLGNKHRDRFDIKADEGGITDIEFIAQYLVLRYAHEKPKLTRWSDNVRILELLAQNGIMDEHEAQALTVAYTTLRDELHHLALQELPGHVAQTCFSKERALVQASWRKWLVAV

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

947 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.067 kDa

MTPLSSPLSQYWQTIVERLPEGFTETSLSVQAKSVLTFSDFALDSVIAHPEWLAELESASPQADEWRHYAGWLQEALAGVCDDASLMRELRFFRRRIMVRIAWAQTLSLVDDETILQQLSHLAETLIVGARDWLYAACCREWGTPCNPQGVPQPLLILGMGKLGGGELNFSSDIDLIFAWPEHGETRGGRRELDNAQFFTRLGQRLIKALDQPTMDGFVYRVDMRLRPFGDSGPLVLSFAALEDYYQEQGRDWERYAMVKARLMGDNDDAWSRELRAMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLKDNIKLGAGGIREIEFIVQVFQLIRGGREPSLQSRSLLPTLDAIAALHLLPENDVAQLRVAYLFLRRLENLLQSINDEQTQTLPADDLNRARLAWGMKAENWPQLVGELTDHMANVRRVFNELIGDDEADTPQEEERSEPWREVWQDALQEDDSTPVLAHLADEDRRQVLTLIADFRKELDKRPIGPRGRQVLDQLMPHLLADVCSREDAAVTLSRITPLLAGIVTRTTYLELLSEFPGALKHLIMLCAASPMIASQLARYPLLLDELLDPGTLYQPTATDAYRDELRQYLLRVPEEDEEQQLEALRQFKQAQLLRIAAADIAGTLPVMKVSDHLTWLAEAMIDAVVQQAWTQMVARYGQPAHLDERQGRGFAVVGYGKLGGWELGYSSDLDLIFLHDCPMDVMTNGEREIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGAAGMLVTSADAFADYQQHEAWTWEHQALVRARVVYGDPQLTSQFDTVRRTIMTTARDGKTLQTEVREMREKMRAHLGNKHRDRFDIKADEGGITDIEFIAQYLVLRYAHEKPKLTRWSDNVRILELLAQNGIMDEHEAQALTVAYTTLRDELHHLALQELPGHVAQTCFSKERALVQASWRKWLVAV

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

947 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.053 kDa

MTPLSSPLSQYWQTVVERLPEGFTETSLSVQAKSVLTFSDFALDSVIAHPEWLAELESASPQADEWRHYAGWLQEALAGVCDDASLMRELRFFRRRIMVRIAWAQTLSLVDDETILQQLSHLAETLIVGARDWLYAACCREWGTPCNPQGVPQPLLILGMGKLGGGELNFSSDIDLIFAWPEHGETRGGRRELDNAQFFTRLGQRLIKALDQPTMDGFVYRVDMRLRPFGDSGPLVLSFAALEDYYQEQGRDWERYAMVKARLMGDNDDAWSRELRAMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLKDNIKLGAGGIREIEFIVQVFQLIRGGREPSLQSRSLLPTLDAIAALHLLPENDVAQLRVAYLFLRRLENLLQSINDEQTQTLPADDLNRARLAWGMKAENWPQLVGELTDHMANVRRVFNELIGDDEADTPQEEERSEPWREVWQDALQEDDSTPVLAHLADEDRRQVLTLIADFRKELDKRPIGPRGRQVLDQLMPHLLADVCSREDAAVTLSRITPLLAGIVTRTTYLELLSEFPGALKHLIMLCAASPMIASQLARYPLLLDELLDPGTLYQPTATDAYRDELRQYLLRVPEEDEEQQLEALRQFKQAQLLRIAAADIAGTLPVMKVSDHLTWLAEAMIDAVVQQAWTQMVARYGQPAHLDERQGRGFAVVGYGKLGGWELGYSSDLDLIFLHDCPMDVMTNGEREIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGAAGMLVTSADAFADYQQHEAWTWEHQALVRARVVYGDPQLTSQFDTVRRTIMTTARDGKTLQTEVREMREKMRAHLGNKHRDRFDIKADEGGITDIEFIAQYLVLRYAHEKPKLTRWSDNVRILELLAQNGIMDEHEAQALTVAYTTLRDELHHLALQELPGHVAQTCFSKERALVQASWRKWLVAV

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

947 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.009 kDa

MTPLSSPLSQYWQTVVERLPEGFTETSLSAQAKSVLTFSDFALDSVIAHPEWLAELESASPQADEWRHYAGWLQEALAGVCDDASLMRELRFFRRRIMVRIAWAQTLSLVDDETILQQLSHLAETLIVGARDWLYAACCREWGTPCNPQGVPQPLLILGMGKLGGGELNFSSDIDLIFAWPEHGETRGGRRELDNAQFFTRLGQRLIKALDQPTMDGFVYRVDMRLRPFGDSGPLVLSFAALEDYYQEQGRDWERYAMVKARLMGDNDDAWSRELRAMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLKDNIKLGAGGIREIEFIVQVFQLIRGGREPSLQSRSLLPTLDAIAALHLLPENDVAQLRVAYLFLRRLENLLQSINDEQTQTLPADDLNRARLAWGMKAENWPQLVGELTDHMANVRRVFNELIGDDEADTPQEEERSEPWREVWQDALQEDDSTPVLAHLADEDRRQVLTLIADFRKELDKRPIGPRGRQVLDQLMPHLLADVCSREDAVVTLSRITPLLAGIVTRTTYLELLSEFPGALKHLIMLCAASPMIASQLARYPLLLDELLDPGTLYQPTATDAYRDELRQYLLRVPEEDEEQQLEALRQFKQAQLLRIAAADIAGTLPVMKVSDHLTWLAEAMIDAVVQQAWTQMVARYGQPAHLDERQGRGFAVVGYGKLGGWELGYSSDLDLIFLHDCPMDVMTNGEREIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGAAGMLVTSADAFADYQQHEAWTWEHQALVRARVVYGDPQLTSQFDAVRRTIMTTARDGKTLQTEVREMREKMRAHLGNKHRDRFDIKADEGGITDIEFIAQYLVLRYAHEKPKLTRWSDNVRILELLAQNGIMDDHEAQALTVAYTTLRDELHHLALQELPGHVAQTCFSKERALVQASWRKWLVAV

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

947 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.085 kDa

MTPLSSPLSQYWQTVVERLPEGFTETSLSVQAKSVLTFSDFALDSVIAHPEWLAELESASPQADEWRHYAGWLQEALAGVCDDASLMRELRFFRRRIMVRIAWAQTLSLVDDETILQQLSHLAETLIVGARDWLYAACCREWGTPCNPQGVPQPLLILGMGKLGGGELNFSSDIDLIFAWPEHGETRGGRRELDNAQFFTRLGQRLIKALDQPTMDGFVYRVDMRLRPFGDSGPLVLSFAALEDYYQEQGRDWERYAMVKARLMGDNDDAWSRELRAMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLKDNIKLGAGGIREIEFIVQVFQLIRGGREPSLQSRSLLPTLDAIAALHLLPENDVAQLRMAYLFLRRLENLLQSINDEQTQTLPADDLNRARLAWGMKAENWPQLVGELTDHMANVRRVFNELIGDDEADTPQEEERSEPWREVWQDALQEDDSTPVLAHLADEDRRQVLTLIADFRKELDKRPIGPRGRQVLDQLMPHLLADVCSREDAAVTLSRITPLLAGIVTRTTYLELLSEFPGALKHLIMLCAASPMIASQLARYPLLLDELLDPGTLYQPTATDAYRDELRQYLLRVPEEDEEQQLEALRQFKQAQLLRIAAADIAGTLPVMKVSDHLTWLAEAMIDAVVQQAWTQMVARYGQPAHLDERQGRGFAVVGYGKLGGWELGYSSDLDLIFLHDCPMDVMTNGEREIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGAAGMLVTSADAFADYQQHEAWTWEHQALVRARVVYGDPQLTSQFDTVRRTIMTTARDGKTLQTEVREMREKMRAHLGNKHRDRFDIKADEGGITDIEFIAQYLVLRYAHEKPKLTRWSDNVRILELLAQNGIMDEHEAQALTVAYTTLRDELHHLALQELPGHVAQTCFSKERALVQASWRKWLVAV

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

947 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

107.909 kDa

MTPLSSPLSQYCQTVVERLPEGFTETSLSAQAKSVLTFSDFALDSVIAHPEWLAELESASPQADEWRHYAGWLQEALAGVCDDASLMRELRLFRRRIMVRIAWAQTLSLVDDETILQQLSHLAETLIVGARDWLYAACCREWGTPCNPQGVPQPLLILGMGKLGGGELNFSSDIDLIFAWPEHGETRGGRRELDNAQFFTRLGQRLIKALDQPTMDGFVYRVDMRLRPFGDSGPLVLSFAALEDYYQEQGRDWERYAMVKARLMGDNDDAWSRELRAMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLKDNIKLGAGGIREIEFIVQVFQLIRGGREPSLQSRSLLPTLDAIAALHLLPENDVAQLRMAYLFLRRLENLLQSINDEQTQTLPADDLNRARLAWGMKAENWPQLVGELTDHMANVRRVFNELIGDDEADTPQEEERSEPWREVWQDALQEDDSTPVLAHLADEDRRQVLTLIADFRKELDKRPIGPRGRQVLDQLMPHLLANVCSREDAAVTLSRITPLLAGIVTRTTYLELLSEFPGALKHLIMLCAASPMIASQLARYPLLLDELLDPGTLYQPTATDAYRDELRQYLLRVPEEDEEQQLEALRQFKQAQLLRIAAADIAGTLPVMKVSDHLTWLAEAMIDAVVQQAWTQMVARYGQPAHLDERQGRGFAVVGYGKLGGWELGYSSDLDLIFLHDCPMDVMTNGEREIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGAAGMLVTSADAFADYQQHEAWTWEHQALVRARVVYGDPQLTSQFDAVRRTIMTTARDGKTLQTEVREMREKMRAHLGNKHRDRFDIKADEGGITDIEFIAQYLVLRYAHEKPKLTRWSDNVRILELLAQNGIMDEHEAQALTVAYTTLRDELHHLALQELPGHVAQTCFSKERALVQASWRKWLVAV

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

947 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.025 kDa

MTPLSSPLSQYWQTVVERLPEGFTETSLSAQAKSVLTFSDFALDSVIAHPEWLAELESASPQADEWRHYAGWLQEALAGVCDDASLMRELRFFRRRIMVRIAWAQTLSLVDDETILQQLSHLAETLIVGARDWLYAACCREWGTPCNPQGVPQPLLILGMGKLGGGELNFSSDIDLIFAWPEHGETRGGRRELDNAQFFTRLGQRLIKALDQPTMDGFVYRVDMRLRPFGDSGPLVLSFAALEDYYQEQGRDWERYAMVKARLMGDNDDAWSRELRAMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLKDNIKLGAGGIREIEFIVQVFQLIRGGREPSLQSRSLLPTLDAIAALHLLPENDVAQLRVAYLFLRRLENLLQSINDEQTQTLPADDLNRARLAWGMKAENWPQLVGELTDHMANVRRVFNELIGDDEADTPQEEERSEPWREVWQDALQEDDSTPVLAHLADEDRRQVLTLIADFRKELDKRPIGPRGRQVLDQLMPHLLADVCSREDAAVTLSRITPLLAGIVTRTTYLELLSEFPGALKHLIMLCAASPMIASQLARYPLLLDELLDPGTLYQPTATDAYRDELRQYLLRVPEEDEEQQLEALRQFKQAQLLRIAAADIAGTLPVMKVSDHLTWLAEAMIDAVVQQAWTQMVARYGQPAHLDERQGRGFAVVGYGKLGGWELGYSSDLDLIFLHDCPMDVMTNGEREIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGAAGMLVTSADAFADYQQHEAWTWEHQALVRARVVYGDPQLTSQFDTVRRTIMTTARDGKTLQTEVREMREKMRAHLGNKHRDRFDIKADEGGITDIEFIAQYLVLRYAHEKPKLTRWSDNVRILELLAQNGIMDEHEAQALTVAYTTLRDELHHLALQELPGHVAQTCFSKERALVQASWRKWLVAV

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

947 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

109.195 kDa

MQLPSSLVSVAESAVQNAQEAGYLQSWPNEVVEQFHYVSALSQFITETIHRDEALAQQLPTMLSELSRHQAYRTRLAALLAECPDEMSGHRVLRQFRNREMVYIAWKDFLHAWTLEESLRHLSQLAEAMIFETYQWQYKICCAEWGTPTNAEGEAQPMLIIGMGKLGGGELNFSSDIDLIFTYPENGETQGARRSIANAQFFTRLGQRIIKALDQQTFDGFCYRVDMRLRPFGESGPLVMSYAALEDYYQEQGRDWERYAMIKARVMGCEMYPQYQELRKMLRPFVFRRYIDFSAIQSLRRMKSMISSEVRRRGLTNNIKLGAGGIREIEFIAQVFQLIRGGREPSLRNRGLLETLSGIEELALLTPQEVSNLEAAYKYLRQLENLLQAMADKQTQTLPDCDIERLKLATAMQLESWDLLIEQTQQHMNKVHQVFETLIGDDEEDEGSTIARHFHELWDMANKQDVLELILEQDIQVEEPAIFSKAIINFKADLAKKTLGPRGREVLNRLMPKVFDAVFAHPDAQFGLPRVLHLLHNICTRTTYLELLDEHPAALVQLVRLCTASPMISEQLSRYPILLDELIDPQQLYNPIPLDSYRTELRDFLARIPEDDMEQQMEALRQFKQICILRIAAADIAGVLPVMKVSDHLTYLAEAIVEAVVSQAWLQVSEKYGEPTHVKDREGKGFAVIGYGKVGGWELGYNSDLDIVFMHDCPVNVYTDGKKEIDGRQFYLRLAQRIIHIFSTRTASGILYEVDTRLRPSGASGLLVSPTDAFDDYQHQDAWTWEHQALVRARMIYGDEPLAIAFHNTRHDVLCKPRDEQTLKKEVVEMREKMRDHLGGKKSGRFMIKQDVGGITDIEFLAQYLVLNYSHEKPKLTRWCDNVRIYETLIAQGVMEEDQAMQLIRAYTAMRNEIHHRNLLNLDADVVEDKFVAEREWVKQAWNQWFA

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

946 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.418 kDa

MKPLSSPLQQYWQTVVERLPEPLAEESLSAQAKSVLTFSDFVQDSVIAHPEWLTELESQPPQADEWQHYAAWLQEALCNVSDEAGLMRELRLFRRRIMVRIAWAQTLALVTEESILQQLSYLAETLIVAARDWLYDACCREWGTPCNAQGEAQPLLILGMGKLGGGELNFSSDIDLIFAWPEHGCTQGGRRELDNAQFFTRMGQRLIKVLDQPTQDGFVYRVDMRLRPFGESGPLVLSFAALEDYYQEQGRDWERYAMVKARIMGDSEGVYANELRAMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLTDNIKLGAGGIREIEFIVQVFQLIRGGREPSLQSRSLLPTLSAIAELHLLSENDAEQLRVAYLFLRRLENLLQSINDEQTQTLPSDELNRARLAWAMDFADWPQLTGALTAHMTNVRRVFNELIGDDESETQEESLSEQWRELWQDALQEDDTTPVLAHLSEDDRKQVLTLIADFRKELDKRTIGPRGRQVLDHLMPHLLSDVCAREDAAVTLSRITALLVGIVTRTTYLELLSEFPAALKHLISLCAASPMIASQLARYPLLLDELLDPNTLYQPTATDAYRDELRQYLLRVPEDDEEQQLEALRQFKQAQLLRIAAADIAGTLPVMKVSDHLTWLAEAMIDAVVQQAWVQMVARYGKPNHLNEREGRGFAVVGYGKLGGWELGYSSDLDLIFLHDCPMDAMTDGEREIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGAAGMLVTSAEAFADYQKNEAWTWEHQALVRARVVYGDPQLTAHFDAVRREIMTLPREGKTLQTEVREMREKMRAHLGNKHRDRFDIKADEGGITDIEFITQYLVLRYAHEKPKLTRWSDNVRILELLAQNDIMEEQEAMALTRAYTTLRDELHHLALQELPGHVSEDCFTAERELVRASWQKWLVEE

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

946 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.388 kDa

MKPLSSPLQQYWQTVVERLPEPLAEESLSAQAKSVLTFSDFVQDSVIAHPEWLTELESQPPQADEWQHYAAWLQEALCNVSDEAGLMRELRLFRRRIMVRIAWAQTLALVTEESILQQLSYLAETLIVAARDWLYDACCREWGTPCNAQGEAQPLLILGMGKLGGGELNFSSDIDLIFAWPEHGCTQGGRRELDNAQFFTRMGQRLIKVLDQPTQDGFVYRVDMRLRPFGESGPLVLSFAALEDYYQEQGRDWERYAMVKARIMGDSEGVYANELRAMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLTDNIKLGAGGIREIEFIVQVFQLIRGGREPSLQSRSLLPTLSVIAALHLLSENDAEQLRVAYLFLRRLENLLQSINDEQTQTLPSDELNRARLAWAMDFADWPQLTGALTAHMTNVRRVFNELIGDDESETQEESLSEQWRELWQDALQEDDTTPVLAHLSEDDRKQVLTLIADFRKELDKRTIGPRGRQVLDHLMPHLLSDVCAREDAAVTLSRITALLVGIVTRTTYLELLSEFPAALKHLISLCAASPMIASQLARYPLLLDELLDPNTLYQPTATDAYRDELRQYLLRVPEDDEEQQLEALRQFKQAQLLRIAAADIAGTLPVMKVSDHLTWLAEAMIDAVVQQAWVQMVARYGKPNHLNEREGRGFAVVGYGKLGGWELGYSSDLDLIFLHDCPMDAMTDGEREIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGAAGMLVTSAEAFADYQKNEAWTWEHQALVRARVVYGDPQLTAHFDAVRREIMTLPREGKTLQTEVREMREKMRAHLGNKHRDRFDIKADEGGITDIEFITQYLVLRYAHEKPKLTRWSDNVRILELLAQNDIMEEQEAMALTRAYTTLRDELHHLALQELPGHVSEDCFTAERELVRASWQKWLVEE

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

946 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.392 kDa

MKPLSSPLQQYWQTVVERLPEPLAEESLSAQAKSVLTFSDFVQDSVIAHPEWLTELESQPPQADEWQHYASWLQEALSNVSDEAGLMRELRLFRRRIMVRIAWAQTLALVTEESILQQLSHLAETLIVAARDWLYDACCREWGTPCNAQGEAQPLLILGMGKLGGGELNFSSDIDLIFAWPEHGCTQGGRRELDNAQFFTRMGQRLIKVLDQPTQDGFVYRVDMRLRPFGESGPLVLSFAALEDYYQEQGRDWERYAMVKARIMGDSDGVYANELRAMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLTDNIKLGAGGIREIEFIVQVFQLIRGGREPSLQSRALLPTLSAIAALHLLSENDAEQLRVAYLFLRRLENLLQSINDEQTQTLPFDELNRARLAWAMDFADWPQLTGVLTAHMANVRRVFNELIGDDESETQEESLSEQWRELWQDALQEDDTTPVLAHLSEDDRKQVLMLIADFRKELDKRTIGPRGRQVLDHLMPHLLSDVCAREDAAVTLSRITALLVGIVTRTTYLELLSEFPAALKHLISLCAASPMIASQLARYPLLLDELLDPNTLYQPTATDAYRDELRQYLLRVPEDDEEQQLEALRQFKQAQLLRIAAADIAGTLPVMKVSDHLTWLAEAMIDAVVQQAWVQMVARYGKPNHLNEREGRGFAVVGYGKLGGWELGYSSDLDLIFLHDCPMDAMTDGEREIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGAAGMLVTSAEAFADYQKNEAWTWEHQALVRARVVYGDPQLTAHFDAVRREIMTLPREGKTLQTEVREMREKMRAHLGNKHRDRFDIKADEGGITDIEFITQYLVLRYAHEKPKLTRWSDNVRILELLAQNDIMEEQEAMALTRAYTTLRDELHHLALQELPGHVSEDCFTAERELVRASWQKWLVEE

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

946 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.418 kDa

MKPLSSPLQQYWQTVVERLPEPLAEESLSAQAKSVLTFSDFVQDSVIAHPEWLTELESQPPQADEWQHYAAWLQEALCNVSDEAGLMRELRLFRRRIMVRIAWAQTLALVTEESILQQLSYLAETLIVAARDWLYDACCREWGTPCNAQGEAQPLLILGMGKLGGGELNFSSDIDLIFAWPEHGCTQGGRRELDNAQFFTRMGQRLIKVLDQPTQDGFVYRVDMRLRPFGESGPLVLSFAALEDYYQEQGRDWERYAMVKARIMGDSEGVYANELRAMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLTDNIKLGAGGIREIEFIVQVFQLIRGGREPSLQSRSLLPTLSAIAELHLLSENDAEQLRVAYLFLRRLENLLQSINDEQTQTLPSDELNRARLAWAMDFADWPQLTGALTAHMTNVRRVFNELIGDDESETQEESLSEQWRELWQDALQEDDTTPVLAHLSEDDRKQVLTLIADFRKELDKRTIGPRGRQVLDHLMPHLLSDVCAREDAAVTLSRITALLVGIVTRTTYLELLSEFPAALKHLISLCAASPMIASQLARYPLLLDELLDPNTLYQPTATDAYRDELRQYLLRVPEDDEEQQLEALRQFKQAQLLRIAAADIAGTLPVMKVSDHLTWLAEAMIDAVVQQAWVQMVARYGKPNHLNEREGRGFAVVGYGKLGGWELGYSSDLDLIFLHDCPMDAMTDGEREIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGAAGMLVTSAEAFADYQKNEAWTWEHQALVRARVVYGDPQLTAHFDAVRREIMTLPREGKTLQTEVREMREKMRAHLGNKHRDRFDIKADEGGITDIEFITQYLVLRYAHEKPKLTRWSDNVRILELLAQNDIMEEQEAMALTRAYTTLRDELHHLALQELPGHVSEDCFTAERELVRASWQKWLVEE

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

946 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia (PubMed:8412694). When cellular nitrogen levels are high, the C-terminal adenylyl transferase inactivates GlnA by covalent transfer of an adenylyl group from ATP to 'Tyr-398' of GlnA, thus reducing its activity (PubMed:4920894, PubMed:9312015). Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity (PubMed:4893578, PubMed:4920873, PubMed:4934180, PubMed:9312015, PubMed:14766310). The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell (PubMed:8412694).

Belongs to the GlnE family.

108.418 kDa

MKPLSSPLQQYWQTVVERLPEPLAEESLSAQAKSVLTFSDFVQDSVIAHPEWLTELESQPPQADEWQHYAAWLQEALCNVSDEAGLMRELRLFRRRIMVRIAWAQTLALVTEESILQQLSYLAETLIVAARDWLYDACCREWGTPCNAQGEAQPLLILGMGKLGGGELNFSSDIDLIFAWPEHGCTQGGRRELDNAQFFTRMGQRLIKVLDQPTQDGFVYRVDMRLRPFGESGPLVLSFAALEDYYQEQGRDWERYAMVKARIMGDSEGVYANELRAMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLTDNIKLGAGGIREIEFIVQVFQLIRGGREPSLQSRSLLPTLSAIAELHLLSENDAEQLRVAYLFLRRLENLLQSINDEQTQTLPSDELNRARLAWAMDFADWPQLTGALTAHMTNVRRVFNELIGDDESETQEESLSEQWRELWQDALQEDDTTPVLAHLSEDDRKQVLTLIADFRKELDKRTIGPRGRQVLDHLMPHLLSDVCAREDAAVTLSRITALLVGIVTRTTYLELLSEFPAALKHLISLCAASPMIASQLARYPLLLDELLDPNTLYQPTATDAYRDELRQYLLRVPEDDEEQQLEALRQFKQAQLLRIAAADIAGTLPVMKVSDHLTWLAEAMIDAVVQQAWVQMVARYGKPNHLNEREGRGFAVVGYGKLGGWELGYSSDLDLIFLHDCPMDAMTDGEREIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGAAGMLVTSAEAFADYQKNEAWTWEHQALVRARVVYGDPQLTAHFDAVRREIMTLPREGKTLQTEVREMREKMRAHLGNKHRDRFDIKADEGGITDIEFITQYLVLRYAHEKPKLTRWSDNVRILELLAQNDIMEEQEAMALTRAYTTLRDELHHLALQELPGHVSEDCFTAERELVRASWQKWLVEE

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

946 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.373 kDa

MKPLSSPLQQYWQTVVERLPEPLAEESLSAQAKSVLTFSDFVQDSVIAHPEWLTELQSQPPQADEWQHYAAWLQEALSNVSDEAGLMRELRLFRRRIMVRIAWAQTLALVTEESILQQLSHLAETLIVAARDWLYDACCREWGTPCNAQGEAQPLLILGMGKLGGGELNFSSDIDLIFAWPEHGCTQGGRRELDNAQFFTRMGQRLIKVLDQPTQDGFVYRVDMRLRPFGESGPLVLSFAALEDYYQEQGRDWERYAMVKARIMGDSEGVYANELRAMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLTDNIKLGAGGIREIEFIVQVFQLIRGGREPSLQSRSLLPTLSAIAALHLLSENDAEQLRVAYLFLRRLENLLQSINDEQTQTLPSDELNRARLAWAMDFADWPQLTGALTVHMTNVRRVFNELIGDDESETQEESLSEQWRELWQDALQEDDTTPVLAHLSEDDRKQVLTLIADFRKELDKRTIGPRGRQVLDHLMPHLLSDVCAREDAAVTLSRITALLVGIVTRTTYLELLSEFPAALKHLISLCAASPMIASQLARYPLLLDELLDPNTLYQPTATDAYRDELRQYLLRVPEDDEEQQLEALRQFKQAQLLRIAAADIAGTLPVMKVSDHLTWLAEAMIDAVVQQAWVQMVVRYGKPNHLNEREGRGFAVVGYGKLGGWELGYSSDLDLIFLHDCPMDAMTDGEREIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGAAGMLVTSAEAFADYQKNEAWTWEHQALVRARVVYGDPQLTAHFDAVRREIMTLPREGKTLQTEVREMREKMRAHLGNKHRDRFDIKADEGGITDIEFITQYLVLRYAHEKPKLTRWSDNVRILELLAQNDIMEEQEAMALTRAYTTLRDELHHLALQELPGHVSEDCFTAERELVRASWQKWLVEE

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

946 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.331 kDa

MKPLSSPLQQYWQTVVERLPEPLAEKSLSAQAKSVLTFSDFVQDSVIAHPEWLTELESQSPQADEWQHYAAWLQEALSNVSDEAGLMRELRLFRRRIMVRIAWAQTLALVTEESILQQLSHLAETLIVAARDWLYDACCREWGTPCNAQGEAQPLLILGMGKLGGGELNFSSDIDLIFAWPEHGCTQGGRRELDNAQFFTRMGQRLIKVLDQPTQDGFVYRVDMRLRPFGESGPLVLSFAALEDYYQEQGRDWERYAMVKARIMGDSEGVYANELRAMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLTDNIKLGAGGIREIEFIVQVFQLIRGGREPSLQSRSLLPTLSVIAALHLLSENDAEQLRVAYLFLRRLENLLQSINDEQTQTLPSDELNRARLAWAMDFADWPQLTGALTAHMTNVRRVFNELIGDDESETQEESLSEQWRELWQDALQEDDTTPVLAHLSEDDRKQVLTLIADFRKELDKRTIGPRGRQVLDHLMPHLLSDVCAREDAAVTLSRITALLVGIVTRTTYLELLSEFPAALKHLISLCAASPMIASQLARYPLLLDELLDPNTLYQPTATDAYRDELRQYLLRVPEDDEEQQLEALRQFKQAQLLRIAAADIAGTLPVMKVSDHLTWLAEAMIDAVVQQAWVQMVARYGKPNHLNDREGRGFAVVGYGKLGGWELGYSSDLDLIFLHDCPMDAMTDGEREIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGAAGMLVTSAEAFADYQKNEAWTWEHQALVRARVVYGDPQLTAHFDAVRREIMTLPREGKTLQTEVREMREKMRAHLGNKHRDRFDIKADEGGITDIEFITQYLVLRYAHEKPKLTRWSDNVRILELLAQNDIMEEQEAMALTRAYTTLRDELHHLALQELPGHVPEDCFTAERELVRASWQKWLVEE

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

946 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.618 kDa

MKPLSSPLQQYWQTVVERLPEPLADESLSAQAKSVLTFSDFVQDSVIAHPEWLTELESQPPQADEWQHYSAWWQEALSNVSDEAGLMRELRLFRRRIMVRIAWAQTLALVTEESILLQLSHLAETLIVAARDWLYDACCREWGTPCNAQGEAQPLLILGMGKLGGGELNFSSDIDLIFAWPEHGCTQGGRRELDNAQFFTRMGQRLIKVLDQPTQDGFVYRVDMRLRPFGESGPLVLSFAALEDYYQEQGRDWERYAMVKARIMGDSEGVYANELRAMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLTDNIKLGAGGIREIEFIVQVFQLIRGGREPSLQSRSLLPTLSAIAELHLLSENDAEQLRVAYLFLRRLENLLQSINDEQTQTLPSDELNRARLAWAMDFADWQQLTGALIGHMTNVRRVFNELIGDDESETQEESLSEQWRELWQDALQEDDTTPVLAHLSEDDRKQVLTLIADFRKELDKRTIGPRGRQVLDHLMPHLLRDVCTREDAAVTLSRITALLVGIVTRTTYLELLSEFPAALKHLISLCAASPMIASQLARYPLLLDELLDPNTLYQPTATDAYRDELRQYLLRVPEDDEEQQLEALRQFKQAQLLRIAAADIAGTLPVMKVSDHLTWLAEAMIDAVVQQAWVQMVARYGKPNHLNEREGRGFAVVGYGKLGGWELGYSSDLDLIFLHDCPMDAMTDGEREIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGAAGMLVTSAEAFADYQKNEAWTWEHQALVRARVVYGDPQLTAHFDAVRREIMTLPREGKTLQTEVREMREKMRAHLGNKHRDRFDIKADEGGITDIEFITQYLVLRYAHEKPKLTRWSDNVRILELLAQNDIMEEQEAMALTRAYTTLRDELHHLALQELPGHVPEDCFTAEREQVRVSWQKWLVEE

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

946 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.305 kDa

MKPLSSPLQQYWQTVVERLPAPLAEESLSAQAKSVLTFSDFVQDSVIAHPEWLTELESQPPQADEWQHYAAWLQKALSDVSDEAGLMRELRLFRRRIMVRIAWAQTLALVTEESILQQLSHLAETLIVAARDWLYEACCREWGTPCNAQGEAQPLLILGMGKLGGGELNFSSDIDLIFAWPEHGCTQGGRRELDNAQFFTRMGQRLIKVLDQPTQDGFVYRVDMRLRPFGESGPLVLSFAALEDYYQEQGRDWERYAMVKARIMGDSDGVYANELRAMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLTDNIKLGAGGIREIEFIVQVFQLIRGGREPSLQSRSLLPTLSTIAALHLLSENDAEQLRVAYLFLRRLENLLQSINDEQTQTLPSDELNRARLAWAMDFADWPQLTGALTGHMTNVRRVFNELIGDDESETQEESLSEQWRELWQDALQEDDTTPVLAHLSEDDRKQVLTLIADFRKELDKRTIGPRGRQVLDHLMPHLLSDVCAREDAAVTLSRITALLVGIVTRTTYLELLSEFPAALKHLISLCAASPMIASQLARYPLLLDELLDPNTLYQPTATDAYRDELRQYLLRVPEDDEEQQLEALRQFKQAQLLRIAAADIAGTLPVMKVSDHLTWLAEAMIDAVVQQAWVQMVARYGKPNHLNEREGRGFAVVGYGKLGGWELGYSSDLDLIFLHDCPMDAMTDGEREIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGAAGMLVTSAEAFADYQKNEAWTWEHQALVRARVVYGDPQLTAQFDAVRREIMTLPREGKTLQTEVREMREKMRAHLGNKHRDRFDIKADEGGITDIEFITQYLVLRYAHEKPKLTRWSDNVRILELLAQNDIMEEQEAMVLTRAYTTLRDELHHLALQELPGHVPEDCFTAERELVRASWQKWLVEE

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

946 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.418 kDa

MKPLSSPLQQYWQTVVERLPEPLAEESLSAQAKSVLTFSDFVQDSVIAHPEWLTELESQPPQADEWQHYAAWLQEALCNVSDEAGLMRELRLFRRRIMVRIAWAQTLALVTEESILQQLSYLAETLIVAARDWLYDACCREWGTPCNAQGEAQPLLILGMGKLGGGELNFSSDIDLIFAWPEHGCTQGGRRELDNAQFFTRMGQRLIKVLDQPTQDGFVYRVDMRLRPFGESGPLVLSFAALEDYYQEQGRDWERYAMVKARIMGDSEGVYANELRAMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLTDNIKLGAGGIREIEFIVQVFQLIRGGREPSLQSRSLLPTLSAIAELHLLSENDAEQLRVAYLFLRRLENLLQSINDEQTQTLPSDELNRARLAWAMDFADWPQLTGALTAHMTNVRRVFNELIGDDESETQEESLSEQWRELWQDALQEDDTTPVLAHLSEDDRKQVLTLIADFRKELDKRTIGPRGRQVLDHLMPHLLSDVCAREDAAVTLSRITALLVGIVTRTTYLELLSEFPAALKHLISLCAASPMIASQLARYPLLLDELLDPNTLYQPTATDAYRDELRQYLLRVPEDDEEQQLEALRQFKQAQLLRIAAADIAGTLPVMKVSDHLTWLAEAMIDAVVQQAWVQMVARYGKPNHLNEREGRGFAVVGYGKLGGWELGYSSDLDLIFLHDCPMDAMTDGEREIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGAAGMLVTSAEAFADYQKNEAWTWEHQALVRARVVYGDPQLTAHFDAVRREIMTLPREGKTLQTEVREMREKMRAHLGNKHRDRFDIKADEGGITDIEFITQYLVLRYAHEKPKLTRWSDNVRILELLAQNDIMEEQEAMALTRAYTTLRDELHHLALQELPGHVSEDCFTAERELVRASWQKWLVEE

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

946 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.388 kDa

MKPLSSPLQQYWQTVVERLPEPLAEESLSAQAKSVLTFSDFVQDSVIAHPEWLTELESQPPQADEWQHYAAWLQEALCNVSDEAGLMRELRLFRRRIMVRIAWAQTLALVTEESILQQLSYLAETLIVAARDWLYDACCREWGTPCNAQGEAQPLLILGMGKLGGGELNFSSDIDLIFAWPEHGCTQGGRRELDNAQFFTRMGQRLIKVLDQPTQDGFVYRVDMRLRPFGESGPLVLSFAALEDYYQEQGRDWERYAMVKARIMGDSEGVYANELRAMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLTDNIKLGAGGIREIEFIVQVFQLIRGGREPSLQSRSLLPTLSVIAALHLLSENDAEQLRVAYLFLRRLENLLQSINDEQTQTLPSDELNRARLAWAMDFADWPQLTGALTAHMTNVRRVFNELIGDDESETQEESLSEQWRELWQDALQEDDTTPVLAHLSEDDRKQVLTLIADFRKELDKRTIGPRGRQVLDHLMPHLLSDVCAREDAAVTLSRITALLVGIVTRTTYLELLSEFPAALKHLISLCAASPMIASQLARYPLLLDELLDPNTLYQPTATDAYRDELRQYLLRVPEDDEEQQLEALRQFKQAQLLRIAAADIAGTLPVMKVSDHLTWLAEAMIDAVVQQAWVQMVARYGKPNHLNEREGRGFAVVGYGKLGGWELGYSSDLDLIFLHDCPMDAMTDGEREIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGAAGMLVTSAEAFADYQKNEAWTWEHQALVRARVVYGDPQLTAHFDAVRREIMTLPREGKTLQTEVREMREKMRAHLGNKHRDRFDIKADEGGITDIEFITQYLVLRYAHEKPKLTRWSDNVRILELLAQNDIMEEQEAMALTRAYTTLRDELHHLALQELPGHVSEDCFTAERELVRASWQKWLVEE

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

946 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.392 kDa

MKPLSSPLQQYWQTVVERLPEPLAEESLSAQAKSVLTFSDFVQDSVIAHPEWLTELESQPPQADEWQHYASWLQEALSNVSDEAGLMRELRLFRRRIMVRIAWAQTLALVTEESILQQLSHLAETLIVAARDWLYDACCREWGTPCNAQGEAQPLLILGMGKLGGGELNFSSDIDLIFAWPEHGCTQGGRRELDNAQFFTRMGQRLIKVLDQPTQDGFVYRVDMRLRPFGESGPLVLSFAALEDYYQEQGRDWERYAMVKARIMGDSDGVYANELRAMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLTDNIKLGAGGIREIEFIVQVFQLIRGGREPSLQSRALLPTLSAIAALHLLSENDAEQLRVAYLFLRRLENLLQSINDEQTQTLPFDELNRARLAWAMDFADWPQLTGVLTAHMANVRRVFNELIGDDESETQEESLSEQWRELWQDALQEDDTTPVLAHLSEDDRKQVLMLIADFRKELDKRTIGPRGRQVLDHLMPHLLSDVCAREDAAVTLSRITALLVGIVTRTTYLELLSEFPAALKHLISLCAASPMIASQLARYPLLLDELLDPNTLYQPTATDAYRDELRQYLLRVPEDDEEQQLEALRQFKQAQLLRIAAADIAGTLPVMKVSDHLTWLAEAMIDAVVQQAWVQMVARYGKPNHLNEREGRGFAVVGYGKLGGWELGYSSDLDLIFLHDCPMDAMTDGEREIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGAAGMLVTSAEAFADYQKNEAWTWEHQALVRARVVYGDPQLTAHFDAVRREIMTLPREGKTLQTEVREMREKMRAHLGNKHRDRFDIKADEGGITDIEFITQYLVLRYAHEKPKLTRWSDNVRILELLAQNDIMEEQEAMALTRAYTTLRDELHHLALQELPGHVSEDCFTAERELVRASWQKWLVEE

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

946 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.418 kDa

MKPLSSPLQQYWQTVVERLPEPLAEESLSAQAKSVLTFSDFVQDSVIAHPEWLTELESQPPQADEWQHYAAWLQEALCNVSDEAGLMRELRLFRRRIMVRIAWAQTLALVTEESILQQLSYLAETLIVAARDWLYDACCREWGTPCNAQGEAQPLLILGMGKLGGGELNFSSDIDLIFAWPEHGCTQGGRRELDNAQFFTRMGQRLIKVLDQPTQDGFVYRVDMRLRPFGESGPLVLSFAALEDYYQEQGRDWERYAMVKARIMGDSEGVYANELRAMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLTDNIKLGAGGIREIEFIVQVFQLIRGGREPSLQSRSLLPTLSAIAELHLLSENDAEQLRVAYLFLRRLENLLQSINDEQTQTLPSDELNRARLAWAMDFADWPQLTGALTAHMTNVRRVFNELIGDDESETQEESLSEQWRELWQDALQEDDTTPVLAHLSEDDRKQVLTLIADFRKELDKRTIGPRGRQVLDHLMPHLLSDVCAREDAAVTLSRITALLVGIVTRTTYLELLSEFPAALKHLISLCAASPMIASQLARYPLLLDELLDPNTLYQPTATDAYRDELRQYLLRVPEDDEEQQLEALRQFKQAQLLRIAAADIAGTLPVMKVSDHLTWLAEAMIDAVVQQAWVQMVARYGKPNHLNEREGRGFAVVGYGKLGGWELGYSSDLDLIFLHDCPMDAMTDGEREIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGAAGMLVTSAEAFADYQKNEAWTWEHQALVRARVVYGDPQLTAHFDAVRREIMTLPREGKTLQTEVREMREKMRAHLGNKHRDRFDIKADEGGITDIEFITQYLVLRYAHEKPKLTRWSDNVRILELLAQNDIMEEQEAMALTRAYTTLRDELHHLALQELPGHVSEDCFTAERELVRASWQKWLVEE

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

946 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia (PubMed:8412694). When cellular nitrogen levels are high, the C-terminal adenylyl transferase inactivates GlnA by covalent transfer of an adenylyl group from ATP to 'Tyr-398' of GlnA, thus reducing its activity (PubMed:4920894, PubMed:9312015). Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity (PubMed:4893578, PubMed:4920873, PubMed:4934180, PubMed:9312015, PubMed:14766310). The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell (PubMed:8412694).

Belongs to the GlnE family.

108.418 kDa

MKPLSSPLQQYWQTVVERLPEPLAEESLSAQAKSVLTFSDFVQDSVIAHPEWLTELESQPPQADEWQHYAAWLQEALCNVSDEAGLMRELRLFRRRIMVRIAWAQTLALVTEESILQQLSYLAETLIVAARDWLYDACCREWGTPCNAQGEAQPLLILGMGKLGGGELNFSSDIDLIFAWPEHGCTQGGRRELDNAQFFTRMGQRLIKVLDQPTQDGFVYRVDMRLRPFGESGPLVLSFAALEDYYQEQGRDWERYAMVKARIMGDSEGVYANELRAMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLTDNIKLGAGGIREIEFIVQVFQLIRGGREPSLQSRSLLPTLSAIAELHLLSENDAEQLRVAYLFLRRLENLLQSINDEQTQTLPSDELNRARLAWAMDFADWPQLTGALTAHMTNVRRVFNELIGDDESETQEESLSEQWRELWQDALQEDDTTPVLAHLSEDDRKQVLTLIADFRKELDKRTIGPRGRQVLDHLMPHLLSDVCAREDAAVTLSRITALLVGIVTRTTYLELLSEFPAALKHLISLCAASPMIASQLARYPLLLDELLDPNTLYQPTATDAYRDELRQYLLRVPEDDEEQQLEALRQFKQAQLLRIAAADIAGTLPVMKVSDHLTWLAEAMIDAVVQQAWVQMVARYGKPNHLNEREGRGFAVVGYGKLGGWELGYSSDLDLIFLHDCPMDAMTDGEREIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGAAGMLVTSAEAFADYQKNEAWTWEHQALVRARVVYGDPQLTAHFDAVRREIMTLPREGKTLQTEVREMREKMRAHLGNKHRDRFDIKADEGGITDIEFITQYLVLRYAHEKPKLTRWSDNVRILELLAQNDIMEEQEAMALTRAYTTLRDELHHLALQELPGHVSEDCFTAERELVRASWQKWLVEE

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

946 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.373 kDa

MKPLSSPLQQYWQTVVERLPEPLAEESLSAQAKSVLTFSDFVQDSVIAHPEWLTELQSQPPQADEWQHYAAWLQEALSNVSDEAGLMRELRLFRRRIMVRIAWAQTLALVTEESILQQLSHLAETLIVAARDWLYDACCREWGTPCNAQGEAQPLLILGMGKLGGGELNFSSDIDLIFAWPEHGCTQGGRRELDNAQFFTRMGQRLIKVLDQPTQDGFVYRVDMRLRPFGESGPLVLSFAALEDYYQEQGRDWERYAMVKARIMGDSEGVYANELRAMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLTDNIKLGAGGIREIEFIVQVFQLIRGGREPSLQSRSLLPTLSAIAALHLLSENDAEQLRVAYLFLRRLENLLQSINDEQTQTLPSDELNRARLAWAMDFADWPQLTGALTVHMTNVRRVFNELIGDDESETQEESLSEQWRELWQDALQEDDTTPVLAHLSEDDRKQVLTLIADFRKELDKRTIGPRGRQVLDHLMPHLLSDVCAREDAAVTLSRITALLVGIVTRTTYLELLSEFPAALKHLISLCAASPMIASQLARYPLLLDELLDPNTLYQPTATDAYRDELRQYLLRVPEDDEEQQLEALRQFKQAQLLRIAAADIAGTLPVMKVSDHLTWLAEAMIDAVVQQAWVQMVVRYGKPNHLNEREGRGFAVVGYGKLGGWELGYSSDLDLIFLHDCPMDAMTDGEREIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGAAGMLVTSAEAFADYQKNEAWTWEHQALVRARVVYGDPQLTAHFDAVRREIMTLPREGKTLQTEVREMREKMRAHLGNKHRDRFDIKADEGGITDIEFITQYLVLRYAHEKPKLTRWSDNVRILELLAQNDIMEEQEAMALTRAYTTLRDELHHLALQELPGHVSEDCFTAERELVRASWQKWLVEE

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

946 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.331 kDa

MKPLSSPLQQYWQTVVERLPEPLAEKSLSAQAKSVLTFSDFVQDSVIAHPEWLTELESQSPQADEWQHYAAWLQEALSNVSDEAGLMRELRLFRRRIMVRIAWAQTLALVTEESILQQLSHLAETLIVAARDWLYDACCREWGTPCNAQGEAQPLLILGMGKLGGGELNFSSDIDLIFAWPEHGCTQGGRRELDNAQFFTRMGQRLIKVLDQPTQDGFVYRVDMRLRPFGESGPLVLSFAALEDYYQEQGRDWERYAMVKARIMGDSEGVYANELRAMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLTDNIKLGAGGIREIEFIVQVFQLIRGGREPSLQSRSLLPTLSVIAALHLLSENDAEQLRVAYLFLRRLENLLQSINDEQTQTLPSDELNRARLAWAMDFADWPQLTGALTAHMTNVRRVFNELIGDDESETQEESLSEQWRELWQDALQEDDTTPVLAHLSEDDRKQVLTLIADFRKELDKRTIGPRGRQVLDHLMPHLLSDVCAREDAAVTLSRITALLVGIVTRTTYLELLSEFPAALKHLISLCAASPMIASQLARYPLLLDELLDPNTLYQPTATDAYRDELRQYLLRVPEDDEEQQLEALRQFKQAQLLRIAAADIAGTLPVMKVSDHLTWLAEAMIDAVVQQAWVQMVARYGKPNHLNDREGRGFAVVGYGKLGGWELGYSSDLDLIFLHDCPMDAMTDGEREIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGAAGMLVTSAEAFADYQKNEAWTWEHQALVRARVVYGDPQLTAHFDAVRREIMTLPREGKTLQTEVREMREKMRAHLGNKHRDRFDIKADEGGITDIEFITQYLVLRYAHEKPKLTRWSDNVRILELLAQNDIMEEQEAMALTRAYTTLRDELHHLALQELPGHVPEDCFTAERELVRASWQKWLVEE

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

946 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.618 kDa

MKPLSSPLQQYWQTVVERLPEPLADESLSAQAKSVLTFSDFVQDSVIAHPEWLTELESQPPQADEWQHYSAWWQEALSNVSDEAGLMRELRLFRRRIMVRIAWAQTLALVTEESILLQLSHLAETLIVAARDWLYDACCREWGTPCNAQGEAQPLLILGMGKLGGGELNFSSDIDLIFAWPEHGCTQGGRRELDNAQFFTRMGQRLIKVLDQPTQDGFVYRVDMRLRPFGESGPLVLSFAALEDYYQEQGRDWERYAMVKARIMGDSEGVYANELRAMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLTDNIKLGAGGIREIEFIVQVFQLIRGGREPSLQSRSLLPTLSAIAELHLLSENDAEQLRVAYLFLRRLENLLQSINDEQTQTLPSDELNRARLAWAMDFADWQQLTGALIGHMTNVRRVFNELIGDDESETQEESLSEQWRELWQDALQEDDTTPVLAHLSEDDRKQVLTLIADFRKELDKRTIGPRGRQVLDHLMPHLLRDVCTREDAAVTLSRITALLVGIVTRTTYLELLSEFPAALKHLISLCAASPMIASQLARYPLLLDELLDPNTLYQPTATDAYRDELRQYLLRVPEDDEEQQLEALRQFKQAQLLRIAAADIAGTLPVMKVSDHLTWLAEAMIDAVVQQAWVQMVARYGKPNHLNEREGRGFAVVGYGKLGGWELGYSSDLDLIFLHDCPMDAMTDGEREIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGAAGMLVTSAEAFADYQKNEAWTWEHQALVRARVVYGDPQLTAHFDAVRREIMTLPREGKTLQTEVREMREKMRAHLGNKHRDRFDIKADEGGITDIEFITQYLVLRYAHEKPKLTRWSDNVRILELLAQNDIMEEQEAMALTRAYTTLRDELHHLALQELPGHVPEDCFTAEREQVRVSWQKWLVEE

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

946 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.305 kDa

MKPLSSPLQQYWQTVVERLPAPLAEESLSAQAKSVLTFSDFVQDSVIAHPEWLTELESQPPQADEWQHYAAWLQKALSDVSDEAGLMRELRLFRRRIMVRIAWAQTLALVTEESILQQLSHLAETLIVAARDWLYEACCREWGTPCNAQGEAQPLLILGMGKLGGGELNFSSDIDLIFAWPEHGCTQGGRRELDNAQFFTRMGQRLIKVLDQPTQDGFVYRVDMRLRPFGESGPLVLSFAALEDYYQEQGRDWERYAMVKARIMGDSDGVYANELRAMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLTDNIKLGAGGIREIEFIVQVFQLIRGGREPSLQSRSLLPTLSTIAALHLLSENDAEQLRVAYLFLRRLENLLQSINDEQTQTLPSDELNRARLAWAMDFADWPQLTGALTGHMTNVRRVFNELIGDDESETQEESLSEQWRELWQDALQEDDTTPVLAHLSEDDRKQVLTLIADFRKELDKRTIGPRGRQVLDHLMPHLLSDVCAREDAAVTLSRITALLVGIVTRTTYLELLSEFPAALKHLISLCAASPMIASQLARYPLLLDELLDPNTLYQPTATDAYRDELRQYLLRVPEDDEEQQLEALRQFKQAQLLRIAAADIAGTLPVMKVSDHLTWLAEAMIDAVVQQAWVQMVARYGKPNHLNEREGRGFAVVGYGKLGGWELGYSSDLDLIFLHDCPMDAMTDGEREIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGAAGMLVTSAEAFADYQKNEAWTWEHQALVRARVVYGDPQLTAQFDAVRREIMTLPREGKTLQTEVREMREKMRAHLGNKHRDRFDIKADEGGITDIEFITQYLVLRYAHEKPKLTRWSDNVRILELLAQNDIMEEQEAMVLTRAYTTLRDELHHLALQELPGHVPEDCFTAERELVRASWQKWLVEE

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

946 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

107.945 kDa

MKPLSSPLQQHWQTVVERLPEILAEATLSVQAKSVLTFSDFVQDSVIAHPEWLTELESAPPQADEWRHYAAWLQDALAQVTDEAALMRELRVFRRRIMVRIAWAQALSLVEEENILQQLSHLAETLIVAARDWLYDACCREWGTPCNHDGVPQPLLILGMGKLGGGELNFSSDIDLIFAWPEHGSTRGGRRELDNAQFFTRMGQRLIKVLDQPTMDGFVYRVDMRLRPFGDSGPLVLSFAALEDYYQEQGRDWERYAMVKARIMGAADSAYVDELRAMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLKDNIKLGAGGIREIEFIVQVFQLIRGGREPSLQSRSLLPTLSAIDALHLLPENDAGQLRAAYLFLRRLENLLQSINDEQTQTLPGDELNRARLAWGMRTDDWSQLTDILAAHMANVRRVFNELIGDDETDTQEDTLSEHWRELWQDALQEDDTTPVLAHLSDDDRGRVLALIADFRKELDKRTIGPRGRQVLDHLMPHLLSDVCSREDASVPLSRITPLLVGIVTRTTYLELLSEFPGALKHLISLCAASPMVASQLARYPLLLDELLDPNTLYQPTATDAYRDELRQYLLRVPEDDEEQQLEALRQFKQTQLLRIAAADIAGTLPVMKVSDHLTWLAEAIIDAVVQQAWGQMVARYGQPTHLAERTGRGFAVVGYGKLGGWELGYSSDLDLIFLHDCPMDVMTDGEREIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGAAGMLVTSAEAFADYQKNEAWTWEHQALVRARVVYGDPQLTSQFDAVRRDIMTLAREGKTLQTEVREMREKMRAHLGNKHRDRFDIKADEGGITDIEFITQYLVLRYAHEKPKLTRWSDNVRILELLAQNDIMDEQEAHALTLAYTTLRDELHHLALQELPGHVAQECFSKERALVRASWQKWLVAG

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

946 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.435 kDa

MKPLSSPLQQYWQTVVERLPEPLAEESLSAQAKSVLTFSDFLQDSIIAHPEWLTELESQPPQADEWQHYAAWLQEALSNVSDEAGLMRELRLFRRRIMVRIAWAQTLALVTEESILQQLSHLAETLIVAARDWLYDACCREWGTPCNAQGEAQPLLILGMGKLGGGELNFSSDIDLIFAWPEHGCTQGGRRELDNAQFFTRMGQRLIKVQDQPTQDGFVYRVDMRLRPFGESGPLVLSFAALEDYYQEQGRDWERYAMVKARIMGDSDGVYANELRAMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLTDNIKLGAGGIREIEFIVQVFQLIRGGREPSLQSRSLLPTLSAIAALHLLSENDAEQLRVAYLFLRRLENLLQSINDEQTQTLPFDELNRARLAWAMDFADWPQLTGVLTAHMANVRRVFNELIGDDESETQEESLSEQWRELWQDALQEDDTTPVLAHLSEDDRKQVLMLIADFRKELDKRTIGPRGRQVLDHLMPHLLSDVCAREDAAVTLSRITALLVGIVTRTTYLELLSEFPAALKHLISLCAASPMIASQLARYPLLLDELLDPNTLYQPTATDAYRDELRQYLLRVPEDDEEQQLEALRQFKQAQLLRIAAADIAGTLPVMKVSDHLTWLAEAMIDAVVQQAWVQMVARYGKPNHLNEREGRGFAVVGYGKLGGWELGYSSDLDLIFLHDCPMDAMTDGEREIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGAAGMLVTSAEAFADYQKNEAWTWEHQALVRARVVYGDPQLTAHFDAVRREIMTLPREGKTLQTEVREMREKMRAHLGNKHRDRFDIKADEGGITDIEFITQYLVLRYAHEKPKLTRWSDNVRILELLAQNDIMEEQEAMALTRAYTTLRDELHHLALQELPGHVSEDCFTAERELVRASWQKWLVEE

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

946 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.317 kDa

MKPLSSPLQQYWQTVVERLPEPLAEESLSAQAKSVLTFSDFVQDSVIAHPEWLTELESQPPQADEWQHYAAWLQEALSNVSDEAGLMRELRLFRRRIMVRIAWAQTLALVTEESILQQLSHLAETLIVAARDWLYDACCREWGTPCNAQGEAQPLLILGMGKLGGGELNFSSDIDLIFAWPEHGCTQGGRRELDNAQFFTRMGQRLIKVLDQPTQDGFVYRVDMRLRPFGESGPLVLSFAALEDYYQEQGRDWERYAMVKARIMGDSDGVYANELRAMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLTDNIKLGAGGIREIEFIVQVFQLIRGGREPSLQSRALLPTLSAIAALHLLSENDAEQLRVAYLFLRRLENLLQSINDEQTQTLPSDELTRARLAWAMDFADWPQLTGVLTAHMANVRRVFNELIGDDESETQEESLSEQWRELWQDALQEDDTTPVLAHLSEDERKQVLMLIADFRKELDKRTIGPRGRQVLDHLMPHLLSDVCAREDAAVTLSRITALLVGIVTRTTYLELLSEFPAALKHLISLCAASPMIASQLARYPLLLDELLDPNTLYQPTATDAYRDELRQYLLRVPEDDEEQQLEALRQFKQAQLLRIAAADIAGTLPVMKVSDHLTWLAEAMIDAVVQQAWVQMVARYGKPNHLNEREGRGFAVVGYGKLGGWELGYSSDLDLIFLHDCPMDAMTDGEREIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGAAGMLVTSAEAFADYQKNEAWTWEHQALVRARVVYGDPQLTAHFDAVRREIMTLPREGKTLQTEVREMREKMRAHLGNKHRDRFDIKADEGGITDIEFITQYLVLRYAHEKPKLTRWSDNVRILELLAQNDIMEEQEAMALTRAYTTLRDELHHLALQELPGHVSEDCFTAERELVRASWQKWLVEE

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

946 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.497 kDa

MKPLSSPLQQYWQTIVERLPEPLAEESLSAQAKSVLTFSDFVQDSISAHPEWLTELESQPPQADEWQHYVAWLQEALINVSDEAGLMRELRLFRRRIMVRIAWAQTLALVTEESILQQLSYLAETLIVAARDWLYDACCREWGTPCNAQGEAQPLLILGMGKLGGGELNFSSDIDLIFAWPEHGCTQGGRWELDNAQFFTRMGQRLIKVLDQPTQDGFVYRVDMRLRPFGESGPLVLSFAALEDYYQEQGRDWERYAMVKARIMGDSEGVYANELRAMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLTDNIKLGAGGIREIEFIVQVFQLIRGGREPSLQSRSLLPTLSVIAALHLLSENDAEQLRVAYLFLRRLENLLQSINDEQTQTLPSDELNRARLAWAMDFADWPQLTGALTAHMTNVRRVFNELIGDDESETQEESLSEQWRELWQDALQEDDTTPVLAHLSEDDRKQVLTLIADFRKELDKRTIGPRGRQVLDHLMPHLLSDVCAREDAAVTLLRITALLAGIVTRTTYLELLSEFPAALKHLISLCAASPMIASQLARYPLLLDELLDPNTLYQPTATDAYRDELRQYLLRVPEDDEEQQLEALRQFKQAQLLRIAAADIAGTLPVMKVSDHLTWLAEAMIDAVVQQAWVQMVARYGKPNHLNEREGRGFAVVGYGKLGGWELGYSSDLDLIFLHDCPMDAMTDGEREIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGAAGMLVTSTEAFADYQKNEAWTWEHQALVRARVVYGDPQLTAHFDAVRREIMTLPREGKTLQTEVREMREKMRAHLGNKHRDRFDIKADEGGITDIEFITQYLVLRYAHEKPKLTRWSDNVRILELLAQNDIMEEQEAMALTRAYTTLRDELHHLALQELPGHVPEDCFTAERELVRASWQKWLVEE

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

946 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.497 kDa

MKPLSSPLQQYWQTIVERLPEPLAEESLSAQAKSVLTFSDFVQDSISAHPEWLTELESQPPQADEWQHYVAWLQEALINVSDEAGLMRELRLFRRRIMVRIAWAQTLALVTEESILQQLSYLAETLIVAARDWLYDACCREWGTPCNAQGEAQPLLILGMGKLGGGELNFSSDIDLIFAWPEHGCTQGGRWELDNAQFFTRMGQRLIKVLDQPTQDGFVYRVDMRLRPFGESGPLVLSFAALEDYYQEQGRDWERYAMVKARIMGDSEGVYANELRAMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLTDNIKLGAGGIREIEFIVQVFQLIRGGREPSLQSRSLLPTLSVIAALHLLSENDAEQLRVAYLFLRRLENLLQSINDEQTQTLPSDELNRARLAWAMDFADWPQLTGALTAHMTNVRRVFNELIGDDESETQEESLSEQWRELWQDALQEDDTTPVLAHLSEDDRKQVLTLIADFRKELDKRTIGPRGRQVLDHLMPHLLSDVCAREDAAVTLLRITALLAGIVTRTTYLELLSEFPAALKHLISLCAASPMIASQLARYPLLLDELLDPNTLYQPTATDAYRDELRQYLLRVPEDDEEQQLEALRQFKQAQLLRIAAADIAGTLPVMKVSDHLTWLAEAMIDAVVQQAWVQMVARYGKPNHLNEREGRGFAVVGYGKLGGWELGYSSDLDLIFLHDCPMDAMTDGEREIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGAAGMLVTSTEAFADYQKNEAWTWEHQALVRARVVYGDPQLTAHFDAVRREIMTLPREGKTLQTEVREMREKMRAHLGNKHRDRFDIKADEGGITDIEFITQYLVLRYAHEKPKLTRWSDNVRILELLAQNDIMEEQEAMALTRAYTTLRDELHHLALQELPGHVPEDCFTAERELVRASWQKWLVEE

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

946 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.418 kDa

MKPLSSPLQQYWQTVVERLPEPLAEESLSAQAKSVLTFSDFVQDSISAHPEWLTELESQPPQADEWQHYVAWLQEALSNVSDEAGLMRELRLFRRRIMVRIAWAQTLALVTEESILQQLSYLAETLIVAARDWLYDACCREWGTPCNAQGEAQPLLILGMGKLGGGELNFSSDIDLIFAWPEHGCTQGGRRELDNAQFFTRMGQRLIKVLDQPTQDGFVYRVDMRLRPFGESGPLVLSFAALEDYYQEQGRDWERYAMVKARIMGDSEGVYANELRAMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLTDNIKLGAGGIREIEFIVQVFQLIRGGREPSLQSRSLLPTLSAIAELHLLSENDAEQLRVAYLFLRRLENLLQSINDEQTQTLPSDELNRARLAWAMDFADWPQLTGALTAHMTNVRRVFNELIGDDESETQEESLSEQWRELWQDALQEDDTTPVLAHLSEDDRKQVLTLIADFRKELDKRTIGPRGRQVLDHLMPHLLSDVCAREDAAVTLSRITALLVGIVTRTTYLELLSEFPAALKHLISLCAASPMIASQLARYPLLLDELLDPNTLYQPTATDAYRDELRQYLLRVPEDDEEQQLEALRQFKQAQLLRIAAADIAGTLPVMKVSDHLTWLAEAMIDAVVQQAWVQMVARYGKPNHLNEREGRGFAVVGYGKLGGWELGYSSDLDLIFLHDCPMDAMTDGEREIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGAAGMLVTSAEAFADYQKNEAWTWEHQALVRARVVYGDPQLTAHFDAVRREIMTLPREGKTLQTEVREMREKMRAHLGNKHRDRFDIKADEGGITDIEFITQYLVLRYAHEKPKLTRWSDNVRILELLAQNDIMEEQEAMALTRAYTTLRDELHHLALQELPGHVSEDCFTAERELVRASWQKWLVEE

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

946 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.423 kDa

MKPLSSPLQQYWQTVVERLPEPLAEESLSAQAKSVLTFSDFVQDSVIAHPEWLTELESQPPQADEWQHYAAWLQEALSNVSDEAGLMRELRLFRRRIMVRIAWAQTLALVTEESILQQLSHLAEMLIVAARDWLYDACCREWGTPCNAQGEAQPLLILGMGKLGGGELNFSSDIDLIFAWPEHGCTQGGRRELDNAQFFTRMGQRLIKVLDQPTQDGFVYRVDMRLRPFGESGPLVLSFAALEDYYQEQGRDWERYAMVKARIMGDSDGVYANELRAMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLTDNIKLGAGGIREIEFIVQVFQLIRGGREPSLQSRSLLPTLSAIAALHLLSENDAEQLRVAYLFLRRLENLLQSINDEQTQTLPFDELNRARLAWAMDFADWPQLTGVLTAHMANVRRVFNELIGDDESETQEESLSEQWRELWQDALQEDDTTPVLAHLSEDDRKQVLMLIADFRKELDKRTIGPRGRQVLDHLMPHLLSDVCAREDAAVTLSRITALLVGIVTRTTYLELLSEFPAALKHLISLCAASPMIASQLARYPLLLDELLDPNTLYQPTATDAYRDELRQYLLRVPEDDEEQQLEALRQFKQAQLLRIAAADIAGTLPVMKVSDHLTWLAEAMIDAVVQQAWVQMVARYGKPNHLNEREGRGFAVVGYGKLGGWELGYSSDLDLIFLHDCPMDAMTDGEREIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGAAGMLVTSAEAFADYQKNEAWTWEHQALVRARVVYGDPQLTAHFDAVRREIMTLPREGKTLQTEVREMREKMRAHLGNKHRDRFDIKADEGGITDIEFITQYLVLRYAHEKPKLTRWSDNVRILELLAQNDIMEEQEAMALTRAYTTLRDELHHLALQELPGHVSEDCFTAERELVRASWQKWLVEE

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

946 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.361 kDa

MKPLSSPLQQYWQTVVERLPEPLAEKSLSAQAKSVLTFSDFVQDSVIAHPEWLTELESQSPQADEWQHYAAWLQEALSNVSDEAGLMRELRLFRRRIMVRIAWAQTLALVTEESILQQLSHLAETLIVAARDWLYDACCREWGTPCNAQGEAQPLLILGMGKLGGGELNFSSDIDLIFAWPEHGCTQGGRRELDNAQFFTRMGQRLIKVLDQPTQDGFVYRVDMRLRPFGESGPLVLSFAALEDYYQEQGRDWERYAMVKARIMGDSEGVYANELRAMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLTDNIKLGAGGIREIEFIVQVFQLIRGGREPSLQSRSLLPTLSAIAALHLLSENDAEQLRVAYLFLRRLENLLQSINDEQTQTLPSDELNRARLAWAMDFADWPQLTGALTAHMTNVRRVFNELIGDDESETQEESLSEQWRELWQDALQEDDTTPVLAHLSEDDRKQVLTLIADFRKELDKRTIGPRGRQVLDHLMPHLLSDVCAREDAAVTLSRITALLVGIVTRTTYLELLSEFRAALKHLISLCAASPMIASQLARYPLLLDELLDPNTLYQPTATDAYRDELRQYLLRVPEDDEEQQLEALRQFKQAQLLRIAAADIAGTLPVMKVSDHLTWLAEAMIDAVVQQAWVQMVARYGKPNHLNDREGRGFAVVGYGKLGGWELGYSSDLDLIFLHDCPMDAMTDGEREIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGAAGMLVTSAEAFADYQKNEAWTWEHQALVRARVVYGDPQLTAHFDAVRREIMTLPREGKTLQTEVREMREKMRAHLGNKHRNRFDIKADEGGITDIEFITQYLVLRYAHEKPKLTRWSDNVRILELLAQNDIMEEQEAMALTRAYTTLRDELHHLALQELPGHVPEDCFTAERELVRASWQKWLVEE

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

946 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.418 kDa

MKPLSSPLQQYWQTVVERLPEPLAEESLSAQAKSVLTFSDFVQDSVIAHPEWLTELESQPPQADEWQHYAAWLQEALCNVSDEAGLMRELRLFRRRIMVRIAWAQTLALVTEESILQQLSYLAETLIVAARDWLYDACCREWGTPCNAQGEAQPLLILGMGKLGGGELNFSSDIDLIFAWPEHGCTQGGRRELDNAQFFTRMGQRLIKVLDQPTQDGFVYRVDMRLRPFGESGPLVLSFAALEDYYQEQGRDWERYAMVKARIMGDSEGVYANELRAMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLTDNIKLGAGGIREIEFIVQVFQLIRGGREPSLQSRSLLPTLSAIAELHLLSENDAEQLRVAYLFLRRLENLLQSINDEQTQTLPSDELNRARLAWAMDFADWPQLTGALTAHMTNVRRVFNELIGDDESETQEESLSEQWRELWQDALQEDDTTPVLAHLSEDDRKQVLTLIADFRKELDKRTIGPRGRQVLDHLMPHLLSDVCAREDAAVTLSRITALLVGIVTRTTYLELLSEFPAALKHLISLCAASPMIASQLARYPLLLDELLDPNTLYQPTATDAYRDELRQYLLRVPEDDEEQQLEALRQFKQAQLLRIAAADIAGTLPVMKVSDHLTWLAEAMIDAVVQQAWVQMVARYGKPNHLNEREGRGFAVVGYGKLGGWELGYSSDLDLIFLHDCPMDAMTDGEREIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGAAGMLVTSAEAFADYQKNEAWTWEHQALVRARVVYGDPQLTAHFDAVRREIMTLPREGKTLQTEVREMREKMRAHLGNKHRDRFDIKADEGGITDIEFITQYLVLRYAHEKPKLTRWSDNVRILELLAQNDIMEEQEAMALTRAYTTLRDELHHLALQELPGHVSEDCFTAERELVRASWQKWLVEE

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

946 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.363 kDa

MKPLSSPLQQYWQTVVERLPEPLAEKSLSTQAKSVLTFSDFVQDSVIAHPEWLTELESQSPQADEWQHYAAWLQEALSNVSDEAGLMRELRLFRRRIMVRIAWAQTLALVTEESILQQLSHLAETLIVAARDWLYDACCREWGTPCNAQGEAQPLLILGMGKLGGGELNFSSDIDLIFAWPEHGCTQGGRRELDNAQFFTRMGQRLIKVLDQPTQDGFVYRVDMRLRPFGESGPLVLSFAALEDYYQEQGRDWERYAMVKARIMGDSEGVYANELRAMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLTDNIKLGAGGIREIEFIVQVFQLIRGGREPSLQSRSLLPTLSVIAALHLLSENDAEQLRVAYLFLRRLENLLQSINDEQTQTLPSDELNRARLAWAMDFADWPQLTGALTAHMTNVRRVFNELIGDDESETQEESLSEQWRELWQDALQEDDTTPVLAHLSEDDRKQVLTLIADFRKELDKRTIGPRGRQVLDHLMPHLLSDVCAREDAAVTLSRITALLVGIVTRTTYLELLSEFPAALKHLISLCAASPMIASQLARYPLLLDELLDPNTLYQPTATDAYRDELRQYLLRVPEDDEEQQLEALRQFKQAQLLRIAAADIAGTLPVMKVSDHLTWLAEAMIDAVVQQAWVQMVARYGKPNHLNDREGRGFAVVGYGKLGGWELGYSSDLDLIFLHDCPMDAMTDGEREIDGRQFYLRLAQRIMHLFNTRTSSGILYEVDARLRPSGAAGMLVTSAEAFADYQKNEAWTWEHQALVRARVVYGDPQLTAHFDAVRREIMTLPREGKTLQTEVREMREKMRAHLGNKHRNRFDIKADEGGITDIEFITQYLVLRYAHEKPKLTRWSDNVRILELLAQNDIMEEQEAMALTRAYTTLRDELHHLALQELPGHVSEDCFTAERDLVRASWQKWLVEE

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

946 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.363 kDa

MKPLSSPLQQYWQTVVERLPEPLAEKSLSAQAKSVLTFSDFVQDSVIAHPEWLTELESQSPQADEWQHYAAWLQEALSNVSDEAGLMRELRLFRRRIMVRIAWAQTLALVTEESILQQLSHLAETLIVAARDWLYDACCREWGTPCNAQGEAQPLLILGMGKLGGGELNFSSDIDLIFAWPEHGCTQGGRRELDNAQFFTRMGQRLIKVLDQPTQDGFVYRVDMRLRPFGESGPLVLSFAALEDYYQEQGRDWERYAMVKARIMGDSEGVYANELRAMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLTDNIKLGAGGIREIEFIVQVFQLIRGGREPSLQSRSLLPTLSVIAALHLLSENDAEQLRVAYLFLRRLENLLQSINDEQTQTLPSDELNRARLAWAMDFADWPQLTGALTAHMTNVRRVFNELIGDDESETQEESLSEQWRELWQDALQEDDTTPVLAHLSEDDRKQVLTLIADFRKELDKRTIGPRGRQVLDHLMPHLLSDVCAREDAAVTLSRITALLVGIVTRTTYLELLSEFPAALKHLISLCAASPMIASQLARYPLLLDELLDPNTLYQPTATDAYRDELRQYLLRVPEDDEEQQLEALRQFKQAQLLRIAAADIAGTLPVMKVSDHLTWLAEAMIDAVVQQAWVQMVARYGKPNHLNDREGRGFAVVGYGKLGGWELGYSSDLDLIFLHDCPMDAMTDGEREIDGRQFYLRLAQRIMHLFNTRTSSGILYEVDARLRPSGAAGMLVTSAEAFADYQKNEAWTWEHQALVRARVVYGDPQLTAHFDAVRREIMMLPREGKTLQTEVREMREKMRAHLGNKHRNRFDIKADEGGITDIEFITQYLVLRYAHEKPKLTRWSDNVRILELLAQNDIMEEQEAMALTRAYTTLRDELHHLALQELPGHVSEDCFTAERDLVRASWQKWLVEE

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

946 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.516 kDa

MKPLSSPLQQYWQTVVERLPEPLAEESLSAQAKLVLTFSDFVQDSVIAHPEWLMELESQPPQADEWQHYAAWLQEALSNVSDEAGLMRELRLFRRRIMVRIAWAQTLALVTEESILQQLSYLAETLIVAARDWLYDACCREWGTPCNAQGEAQPLLILGMGKLGGGELNFSSDIDLIFAWPEHGCTQGGRRELDNAQFFTRMGQRLIKVLDQPTQDGFVYRVDMRLRPFGESGPLVLSFAALEDYYQEQGRDWERYAMVKARIMGDSEGVYANELRAMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLTDNIKLGAGGIREIEFIVQVFQLIRGGREPSLQSRSLLPTLSVIAALHLFSENDAKQLRVAYLFLRRLENLLQSINDEQTQTLPSDELNRARLAWAMDFADWPQLTGVLTAHMTNVRRVFNELIGDDESETQEESLSEQWRELWQDALQEDDTTPVLAHLSEDDRKQVLTLIADFRKELDKRTIGPRGRQVLDHLMPHLLSDVCAREDAAVTLSRITALLVGIVTRTTYLELLSEFPAALKHLISLCAASPMIASQLARYPLLLDELLDPNTLYQPTATDAYRDELRQYLLRVPEDDEEQQLEALRQFKQAQLLRIAAADIAGTLPVMKVSDHLTWLAEAMIDAVVQQAWVQMVARYGKPNHLNEREGRGFAVVGYGKLGGWELGYSSDLDLIFLHDCPMDAMTDGEREIDVRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGAAGMLVTSAEAFADYQKNEAWTWEHQALVRARVVYGDPQLTAHFDAVRREIMALPREGKTLQTEVREMREKMRAHLGNKHRDRFDIKADEGGITDIEFITQYLVLRYAHEKPKLTRWSDNVRILELLAQNDIMEEQEAMVLTRAYTTLRDELHHLALQELPGHVSEDCFTAERDLVRASWQKWLVEE

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

946 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.391 kDa

MKPLSSPLQQYWQTVVERLPELLAEESLSAQAKSVLTFSDFVQDSVIAHPEWLTELESQPPQADEWQHYSVWLQEALSNVSDEAGLMRELRLFRRRIMVRIAWAQTLALVTEESILQQLSYLAETLIVAARDWLYDACCREWGTPCNAQGEAQPLLILGMGKLGGGELNFSSDIDLIFAWPEHGCTQGGRRELDNAQFFTRMGQRLIKVLDQPTQDGFVYRVDMRLRPFGESGPLVLSFAALEDYYQEQGRDWERYAMVKARIMGDSEGVYANELRAMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLTDNIKLGAGGIREIEFIVQVFQLIRGGREPLLQSRSLLPTLSAIAALHLLSENDAEQLRVAYLFLRRLENLLQSINDEQTQTLPSDELNRARLAWAMDFADWPQLTGALTAHMTNVRRVFNELIGDDESETQEESLSEQWRELWQDALQEDDTTPVLAHLSEDDRKQVLTMIADFRKELDKRTIGPRGRQVLDHLMPHLLSDVCAREDAAVTLSRITALLVGIVTRTTYLELLSEFPAALKHLISLCAASPMIASQLARYPLLLDELLDPNTLYQPTATDAYRDELRQYLLRVPEDDEEQQLEALRQFKQAQLLRIAAADIAGTLPVMKVSDHLTWLAEAMIDAVVQQAWGQMVARYGKPNHLNEREGRGFAVVGYGKLGGWELGYSSDLDLIFLHDCPMDAMTDGEREIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGAAGMLVTSAEAFADYQKNEAWTWEHQALVRARVVYGDPQLTAHFDAVRREIMTLPREGKTLQTEVREMREKMRAHLGNKHRNRFDIKADEGGITDIEFITQYLVLRYAHEKPKLTRWSDNVRILELLAQNDIMEEQEAMALTRAYTTLRDELHHLALQELPGHVSEDCFTAERDLVRASWQKWLVEE

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

946 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.317 kDa

MKPLSSPLQQYRQTVVERLPEPLAEEPLSAQAKSVLTFSDFVQDSIIAHREWLTELESQPPQADEWQHYAAWLQEALSNVSDEAGLMRELRLFRRRIMVRIAWAQTLALVTEESILQQLSYLAETLIVAARDWLYDACCREWGTPCNAQGEAQPLLILGMGKLGGGELNFSSDIDLIFAWPEHGCTQGGRRELDNAQFFTRMGQRLIKVLDQPTQDGFVYRVDMRLRPFGESGPLVLSFAALEDYYQEQGRDWERYAMVKARIMGDSEGVYANELRAMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLTDNIKLGAGGIREIEFIVQVFQLIRGGREPSLQSCSLLPTLSAIAALHLLSENDAEQLRVAYLFLRRLENLLQSINDEQTQTLPSDELNRARLAWAMDFADWPQLTGALTAHMNNVRRVFNELIGDDESETQEESLSEQWRELWQDALQEDDTTPVLAHLSEDDRKQVLTLISDFRKELDKRTIGPRGRQVLDHLMPHLLSDVCAREDAAVTLSRITALLVGIVTRTTYLELLSEFPAALNHLISLCAASPMIASQLARYPLLLDELLDPNTLYQPTATDAYRDELRQYLLRVPEDDEEQQLEALRQFKQAQLLRIAAADIAGTLPVMKVSDHLTWLAEAMIDAVVQQAWVQMVARYGKPNHLNDREGRGFAVVGYGKLGGWELGYSSDLDLIFLHDCPMDAMTDGEREIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGAAGMLVTSTEAFADYQKNEAWTWEHQALVRARVVYGDPQLTAHFDAVRREIMTLPREGRTLQTEVREMREKMRAHLGNKHRDRFDIKADEGGITDIEFITQYLVLRYAHEKPKLTRWSDNVRILELLAQNDIMEEQEAMALTRAYTTLRDELHHLALQELPGHVSGDCFTAERDLVRASWQKWLVEE

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

946 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.904 kDa

MSLLNDAALHHFENLNNRIDLNSLKLSQHTELMKVLGLSDFVAESLIKQPALLTDLLDNELLSLADRKEVITTELESAIAKVKDEVTLHRVLRLFRRKHMVVIAWRELLGKAHLVESLDHISYLADQLILQCMSWLYKKQCVEQGIPMNNEGVRQPFFIFAMGKLGGKELNFSSDIDLIFTYPERGETQGERRRIDNQSFFTKLGQRIIGALHQTTVDGFVYRVDMRLRPFGESGPLITNFASIEDYYQSHGRDWERYAMIKARVMGEEGDYKTTLEALLKPFVYRRYIDFSAIESLRKMKAMISSEVRRKGLKDNIKLGKGGIREIEFVAQAFQLIRGGRRAELQCKGLRETLKVLAEIGEVPKERVQSLLDAYHFLRAVENVLQQIGDKQTQTLPDNELDKLRLITVMGYSNWQDFYSKLNQEMDNVHAEFNWVIGDDEEAHDEADQALSELWALHLSQQEATHLLHEKGLDESLAAHFATALSALKEELKKRPIGPRGQATLDKLMPRMIELICVYPDPVELLNRITQLLLKIISRTAYLELLNENDGALKQLLKLCNESTRVASQLARHPILLDELLDPQQLYKPTQLDNYRTELQLFMLRIPEEDMEQQMEALRQFKQIQFLYIAAADIEKSIQLPQVSDHLTYLSEAIMDYVVQIAWLQMVDKFGLPSNVIGSDRKGFAVIGYGKMGGIELGYGSDLDVVFLHDDNIKGETNGRRKIDNQLFYFRLAQRIIHLFSARTNSGILYEIDMRLRPSGDSGILVSSVASYKKYLQNNAWTWEHQALVRARAVFFDKLILAKFNEARETVLSQARNNSALATEIRDMRAKMRKHLSREKEGQFDLKQSPGGMVDIEFFAQYLVLAHACHCGEELCKWSDNLRIFETCRKLGLLTLDEEKKLTGAYCALRDATHRLTLNKKTRIIKGDQFIQERQNVIKIWEKFLD

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

945 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

107.611 kDa

MMPLSPQLQQHWQTVADRLPADFPIAELSPQARSVMAFSDFVEQSVIAQPGWLNELADSSPEAEEWRHYEAWLQDRLQAVTDEAGLMRELRLFRRQMMVRIAWAQALSLVSEEETLQQLSALAETLIVAARDWLYAACCKEWGTPCNAEGQPQPLLILGMGKLGGGELNFSSDIDLIFAWPEHGATRGGRRELDNAQFFTRLGQRLIKALDQPTQDGFVYRVDMRLRPFGDSGPLVLSFAALEDYYQEQGRDWERYAMVKARIMGDNDGVYASELRAMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLKDNIKLGAGGIREIEFIVQVFQLIRGGREPALQQRALLPTLAAIDELHLLPEGDAALLREAYLFLRRLENLLQSINDEQTQTLPQDELNRARLAWGMHTEDWETLSAQLASQMANVRRVFNELIGDDEDQSPDEQLAEYWRELWQDALEEDDASPALAHLNDTDRRSVLALIADFRKELDRRTIGPRGRQVLDQLMPHLLSEICSRADAPLPLARITPLLTGIVTRTTYLELLSEFPGALKHLITLCAASPMVASQLARHPLLLDELLDPNTLYQPTATDAYRDELRQYLLRVPEEDEEQQLEALRQFKQAQQLHIAAADIAGTLPVMKVSDHLTWLAEAILDAVVQQAWGQMVARYGQPTHLHDRQGRGFAVVGYGKLGGWELGYSSDLDLVFLHDCPAEVMTDGEREIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGAAGMLVTTADAFADYQQNEAWTWEHQALVRARVVYGDPALQARFDAIRRDILTTPREGTTLQTEVREMREKMRAHLGNKHPDRFDIKADAGGITDIEFITQYLVLRYASDKPKLTRWSDNVRILELLAQNDIMDEEEARALTHAYTTLRDALHHLALQEQPGHVAPEAFSRERQQVSASWQKWLMA

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

945 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

107.466 kDa

MMPLSPQLQQHWQTVADRLPADFPVAELSPQARSVMAFSDFVEQSVIAQPGWLNELADSAPAAEEWRHYEAWLQERLQAVTDEAGLMRELRLFRRQMMVRIAWAQALSLVREEETLQQLSVLAETLIVAARDWLYAACCKEWGTPCNAEGQPQPLLILGMGKLGGGELNFSSDIDLIFAWPEHGATRGGRRELDNAQFFTRLGQRLIKALDQPTQDGFVYRVDMRLRPFGDSGPLVLSFAALEDYYQEQGRDWERYAMVKARIMGDNDGAYASELRAMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLKDNIKLGAGGIREIEFIVQVFQLIRGGREPALQQRALLPTLAAIDELHLLPEGDATLLRAAYLFLRRLENLLQSINDEQTQTLPQDELNRARLAWGMHTDDWETLSAQLANHMANVRRVFNELIGDDEAQSPDEQLAEYWRELWQDALEEDDASPALAHLNDADRRSVLALIADFRKELDRRTIGPRGRQVLDQLMPHLLSEICSRADAPLPLARITPLLTGIVTRTTYLELLSEFPGALKHLITLCAASPMVASQLARHPLLLDELLDPNTLYQPTATDAYRDELRQYLLRVPEEDEEQQLEALRQFKQAQQLHIAAADIAGTLPVMKVSDHLTWLAEAILDAVVQQAWGQMVARYGLPTHLHDRQGRGFAVVGYGKLGGWELGYSSDLDLVFLHDCPAEVMTDGEREIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGAAGMLVTTADAFADYQQNEAWTWEHQALVRARVVYGDPALQARFDAIRRDILTTPREGATLQTEVREMREKMRAHLGNKHPNRFDIKADAGGITDIEFITQYLVLRYASDKPKLTRWSDNVRILELLAQNDIMDEEEARALTHAYTTLRDALHHLALQELPGHVAPEAFSREREQVSASWQKWLMA

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

945 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

107.611 kDa

MMPLSPQLQQHWQTVADRLPADFPIAELSPQARSVMAFSDFVEQSVIAQPGWLNELADSSPEAEEWRHYEAWLQDRLQAVTDEAGLMRELRLFRRQMMVRIAWAQALSLVSEEETLQQLSALAETLIVAARDWLYAACCKEWGTPCNAEGQPQPLLILGMGKLGGGELNFSSDIDLIFAWPEHGATRGGRRELDNAQFFTRLGQRLIKALDQPTQDGFVYRVDMRLRPFGDSGPLVLSFAALEDYYQEQGRDWERYAMVKARIMGDNDGVYASELRAMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLKDNIKLGAGGIREIEFIVQVFQLIRGGREPALQQRALLPTLAAIDELHLLPEGDAALLREAYLFLRRLENLLQSINDEQTQTLPQDELNRARLAWGMHTEDWETLSAQLASQMANVRRVFNELIGDDEDQSPDEQLAEYWRELWQDALEEDDASPALAHLNDTDRRSVLALIADFRKELDRRTIGPRGRQVLDQLMPHLLSEICSRADAPLPLARITPLLTGIVTRTTYLELLSEFPGALKHLITLCAASPMVASQLARHPLLLDELLDPNTLYQPTATDAYRDELRQYLLRVPEEDEEQQLEALRQFKQAQQLHIAAADIAGTLPVMKVSDHLTWLAEAILDAVVQQAWGQMVARYGQPTHLHDRQGRGFAVVGYGKLGGWELGYSSDLDLVFLHDCPAEVMTDGEREIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGAAGMLVTTADAFADYQQNEAWTWEHQALVRARVVYGDPALQARFDAIRRDILTTPREGTTLQTEVREMREKMRAHLGNKHPDRFDIKADAGGITDIEFITQYLVLRYASDKPKLTRWSDNVRILELLAQNDIMDEEEARALTHAYTTLRDALHHLALQEQPGHVAPEAFSRERQQVSASWQKWLMA

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

945 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

107.466 kDa

MMPLSPQLQQHWQTVADRLPADFPVAELSPQARSVMAFSDFVEQSVIAQPGWLNELADSAPAAEEWRHYEAWLQERLQAVTDEAGLMRELRLFRRQMMVRIAWAQALSLVREEETLQQLSVLAETLIVAARDWLYAACCKEWGTPCNAEGQPQPLLILGMGKLGGGELNFSSDIDLIFAWPEHGATRGGRRELDNAQFFTRLGQRLIKALDQPTQDGFVYRVDMRLRPFGDSGPLVLSFAALEDYYQEQGRDWERYAMVKARIMGDNDGAYASELRAMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLKDNIKLGAGGIREIEFIVQVFQLIRGGREPALQQRALLPTLAAIDELHLLPEGDATLLRAAYLFLRRLENLLQSINDEQTQTLPQDELNRARLAWGMHTDDWETLSAQLANHMANVRRVFNELIGDDEAQSPDEQLAEYWRELWQDALEEDDASPALAHLNDADRRSVLALIADFRKELDRRTIGPRGRQVLDQLMPHLLSEICSRADAPLPLARITPLLTGIVTRTTYLELLSEFPGALKHLITLCAASPMVASQLARHPLLLDELLDPNTLYQPTATDAYRDELRQYLLRVPEEDEEQQLEALRQFKQAQQLHIAAADIAGTLPVMKVSDHLTWLAEAILDAVVQQAWGQMVARYGLPTHLHDRQGRGFAVVGYGKLGGWELGYSSDLDLVFLHDCPAEVMTDGEREIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGAAGMLVTTADAFADYQQNEAWTWEHQALVRARVVYGDPALQARFDAIRRDILTTPREGATLQTEVREMREKMRAHLGNKHPNRFDIKADAGGITDIEFITQYLVLRYASDKPKLTRWSDNVRILELLAQNDIMDEEEARALTHAYTTLRDALHHLALQELPGHVAPEAFSREREQVSASWQKWLMA

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

945 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

107.869 kDa

MLPLSAALQTQAQNIVQRFQETQGADCALSSQELWVLASSDFVCDMLQSQPEWLATLRKQPPVADEWQHYAAWLQDDLEEVRDEAQLMRALRLFRRETLVRIAWAQALGQCSTQETLLQLSGLAETLIVSARDWLYQTCCREWGTPCNAQGVPQPLLILGMGKLGGGELNFSSDIDLIFAYPENGQTQGGRRELDNAQFFTRLGQRLIKALDQQTIDGFVYRVDMRLRPFGDSGPLVMSFAALEDYYQEQGRDWERYAMVKARLMGGSEDAYSEELRKTLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLKDNIKLGAGGIREIEFITQVFQLIRGGREPALQGRSLLPTLQAVGELGLLEPQQVQAMSASYLFLRRLENLLQAIADQQTQTLPQDELDQARLAWGMGFDDWSALLLALDHHMQAVRAVFNDLIGDDSPDVGEDPDYQHYHSLWQDALEENELAPLTPHLDEEARRQMLRTIAEFRHDVDKRTIGPRGRDVLDQLMPRLLAEVCPRQDAPTALLRLTQLLLSIVTRTTYLELLVEYHAALSHLIRLCAASPMVANQLSRYPLLLDELLEPATLYQPVAPDAYRSELRQYLLRVPEDDEEQRLEALRQFKQAQQLRIAAGDISGALPVMKVSDHLTYLAEAIIDTVVQQAWNDMVARYGQPTHLQEREGRGFAVIGYGKLGGWELGYSSDLDLVFILDCPPEVMTDGDRSIDGRQFYLRLAQRVMHLFSTRTSSGILYEVDARLRPSGAAGMLVSTVEAFADYQQSEAWTWEHQALVRARIVHGDPLLHQQFDVIRREILCKPRDLETLKREVREMREKMRNHLGNKQRELFDIKADEGGITDIEFIAQYLVLGYAAAEPRLTRWSDNVRIFELMANYDIMPEEEARALTQAYVTMRDEIHHLALQEHSGKIGNGQFAAEREQVRASWAKWLG

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

944 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

108.901 kDa

MSANSVFQQLWDKAQCTFSTKLNELAPFSEREQQFFAFSPFATEHLRVNPHWLTEIRQTPPVSDEWQNYSSQLKQQLTHVDNEDDLMAILRQFRHQQLVRIAWSQFFQLCDTPCTLKQLSVLAETLISVAKDKLYQQCCQQWGTPCDREGKPQPLLILGMGKLGGLELNFSSDIDLIFAYPENGVTQGGRRELDNAQFFTRLGQKLIKVLDQHTMDGFVYRVDMRLRPFGESGPLVMSFAALEDYYQEQGRDWERYAMVKARVLGAEKKEYCQILRQMLRPFVYRRYIDFSVIQSLRNMKSMISREVRRRGMIDNIKLGAGGIREIEFITQVFQLIRGGREPELQSHSLLTVLNVIAKLELLSAQETSQLADSYLFLRRLENLLQSIADQQTQTLPDNLEDKARLAFAMGFDDWQMLYQQINQKMQAVSVIFTQLIGEDDENEDEEDVSEFKRLWLLGRLPDSATLFHQGLTAEDRQAICQTLQLFRQDISKRTIGPRGRDVLDALMPKLLAKVCLQPQALVILQRITPLLLGIVSRTTYLELMQESDEVLTHVVRLCAASPMIAEQLTRHPLLLDELLDPHSLYQPLPLNAYQDELRQYLLRVPEEDEEQRLEALRQFKQAQLLRIAAEDIAGVLPVMKVSDHLTYLAEAIIHAVVHQAWSYMVKRYGEPAHLAQRDGLGFAVVGYGKLGGWELGYSSDLDLVFLLDCPMNILTTGAKQIDARQFYLRLAQRIIHLFSTRTSSGVLYEVDARLRPSGESGMLVSTIQAFDEYQKNEAWTWEHQALIRARMIYGDDQLQQMFARTRHETLCLARNATVLQQEVREMRQKMVQHLAPTQSNTFDLKASSGGITDIEFIAQYLVLRFSHQYPALTRWSDNVRILELMAKYQVMSEQEAQLLTQAYVTLRNELHHLALQTLPAVVDGDCFITERQWVLSSKQKWLDE

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

941 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

104.306 kDa

MSSAPPFAAALAWSGHLRRRLDAHPDLAAWLANACAHPVSANVLAAWQAELSGPDAPEVLPVEQCRGMLRKLRERVFLTLIVRDLGGQADLEEVVGAMTVLADIAVGTAYRSVAAELAAVHGLPREQSTGDPQEMLIVGMGKLGGRELNVSSDIDLVMLYGDEGETDGPRRISNHEFYGRLTRRMMPVLSEVDADGQVFRTDLRLRPDGDAGPLAWSLDALEHYLIGQGREWERYAWLKARLMPAQAFADSNPDAQARQLESLRVPFVYRKYFDFDALAALRALRERIRQDWQRRALARNGVDSANNIKLGDGGIREIEFIVQLSQLIRGGRMPALQRRGLLEALHAERAAGLVPEGDAQKLEAAYRFLRRTEHALQYREDEQTHLLPADPAQRAALAAALGYEPAAFERTLAEHRAFVSQTFRNAFRLAGMGEEDDSPAPARTPANGHGMRPHAGALHDIEERLAGQIQRDFPEHAEDLLRRTETLLGSHRVRSLPDSSRHRLEALLPAALTAAAQTSAPMDAALRLFDLIETIAQRSAYLALLAEYPDTLARVARMVAASPWAAQYLTQHPLLLDSLIDWRTLFEPLDFAQVARQLAADLDACRLPDGEPDIERQMNLMRDVQRQASFQLLAQDLEGELTVEKLADQLSALADLLLAETIRRVWPLVNRRPGAEPHLAVIAYGKLGGKELGYASDLDLVFLFDDDREDAAELYAKLGRRMTSWLSTMTSSGRLYEVDLRLRPDGDAGLLAVSLEAFEQYQRSHAWPWEHQALTRARYAAGDTEAGARFERIRADILVMPRDVQALRGEVLGMRDKISAGHPNRSELFDVKHDRGGMVDVEFVTQYLVLCHAATHRVLVNNLGNIALLRLAGEAGLIPAPLALAAGDAYRTLRRAQHQLRLKGVDKARVPPGQLAAERATVCELWQTVLQDGTIAQAEVK

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

941 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

104.312 kDa

MSSAPPFAAALAWSGHLRRRLDAHPDLAAWLANACAHPVSANVLAAWQAELSGPDAPEVLPVEQCRGMLRKLRERVFLTLIVRDLGGQADLEEVVGAMTVLADIAVGTAYRSVAAELAAVHGLPREQSTGDPQEMLIVGMGKLGGRELNVSSDIDLVMLYGDEGETDGPRRISNHEFYGRLTRRMMPALSEVDADGQVFRTDLRLRPDGDAGPLAWSLDALEHYLIGQGREWERYAWLKARLMPAQAFADSNPDAQARQLESLRVPFVYRKYFDFDALAALRALRERIRQDWQRRALARNGVDSANNIKLGDGGIREIEFIVQLSQLIRGGRMPALQRRGLLEALHAERAAGLVPEGDAQKLEAAYRFLRRTEHALQYREDEQTHLLPADPAQRAALAAALGYEPAAFERTLAEHRAFVSQTFRNAFRLAGMGEEDDSPAPARTHANGHAMRPHAGALHDIEERLAGQIQRDFPEHAEDLLRRTETLLGSHRVRSLPDSSRHRLEALLPAALTAAAQTSAPMDAALRLFDLIETIAQRSAYLALLAEYPDTLARVARMVAASPWAAQYLTQHPLLLDSLIDWRTLFEPLDFAQVAHQLAADLDACRLPDGEPDIERQMNLMRDVQRQASFQLLAQNLEGELTVEKLADQLSALADLLLAETIRRVWPLVNRRPGAEPHLAVIAYGKLGGKELGYASDLDLVFLFDDDREDAAELYAKLGRRMTSWLSTMTSSGRLYEVDLRLRPDGDAGLLAVSLEAFEQYQRSHAWPWEHQALTRARYAAGDTEAGARFERIRADILVMPRDVQALRGEVLGMRDKISAGHPNRSELFDVKHDRGGMVDVEFVTQYLVLCHAATHRVLVNNLGNIALLRLAGEAGLIPAPLALAAGDAYRTLRRAQHQLRLKGVDKARVPPGQLAAERATVCELWQTVLQDGTIAQAEVK

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

941 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

104.312 kDa

MSSAPPFAAALAWSGHLRRRLDAHPDLAAWLANACAHPVSANVLAAWQAELSGPDAPEVLPVEQCRGMLRKLRERVFLTLIVRDLGGQADLEEVVGAMTVLADIAVGTAYRSVAAELAAVHGLPREQSTGDPQEMLIVGMGKLGGRELNVSSDIDLVMLYGDEGETDGPRRISNHEFYGRLTRRMMPVLSEVDADGQVFRTDLRLRPDGDAGPLAWSLDALEHYLIGQGREWERYAWLKARLMPAQAFADSNPDAQARQLESLRVPFVYRKYFDFDALAALRALRERIRQDWQRRALARNGVDSANNIKLGDGGIREIEFIVQLSQLIRGGRMPALQRRGLLEALHAERAAGLVPEGDAQKLEAAYRFLRRTEHALQYREDEQTHLLPADPAQRAALAAALGYEPAAFERTLAEHRAFVSQTFRNAFRLAGMGEEDDSPAPARTHANGHAMRPHAGALHDIEERLAGQIQRDFPEHAEDLLRRTETLLGSHRVRSLPDSSRHRLEALLPAALTAATQTSAPMDAALRLFDLIETIAQRSAYLALLAEYPDTLARVARMVAASPWAAQYLTQHPLLLDSLIDWRTLFEPLDFAQVAHQLAADLDACRLPDGEPDIERQMNLMRDVQRQASFQLLAQDLEGELTVEKLADQLSALADLLLAETIRRVWPLVNRRPGAEPHLAVIAYGKLGGKELGYASDLDLVFLFDDDREDAAELYAKLGRRMTSWLSTMTSSGRLYEVDLRLRPDGNAGLLAVSLEAFEQYQRSHAWPWEHQALTRARYAAGDTEAGARFERIRADILVMPRDVQALRGEVLGMRDKISAGHPNRSELFDVKHDRGGMVGVEFVTQYLVLCHAATHRVLVNNLGNIALLRLAGEAGLIPAPLALAAGDAYRTLRRAQHQLRLKGVDKARVPPGQLAAERATVCELWQTVLQDGTIAQAEVK

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

941 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

104.306 kDa

MSSAPPFAAALAWSGHLRRRLDAHPDLAAWLANACAHPVSANVLAAWQAELSGPDAPEVLPVEQCRGMLRKLRERVFLTLIVRDLGGQADLEEVVGAMTVLADIAVGTAYRSVAAELAAVHGLPREQSTGDPQEMLIVGMGKLGGRELNVSSDIDLVMLYGDEGETDGPRRISNHEFYGRLTRRMMPVLSEVDADGQVFRTDLRLRPDGDAGPLAWSLDALEHYLIGQGREWERYAWLKARLMPAQAFADSNPDAQARQLESLRVPFVYRKYFDFDALAALRALRERIRQDWQRRALARNGVDSANNIKLGDGGIREIEFIVQLSQLIRGGRMPALQRRGLLEALHAERAAGLVPEGDAQKLEAAYRFLRRTEHALQYREDEQTHLLPADPAQRAALAAALGYEPAAFERTLAEHRAFVSQTFRNAFRLAGMGEEDDSPAPARTPANGHGMRPHAGALHDIEERLAGQIQRDFPEHAEDLLRRTETLLGSHRVRSLPDSSRHRLEALLPAALTAAAQTSAPMDAALRLFDLIETIAQRSAYLALLAEYPDTLARVARMVAASPWAAQYLTQHPLLLDSLIDWRTLFEPLDFAQVARQLAADLDACRLPDGEPDIERQMNLMRDVQRQASFQLLAQDLEGELTVEKLADQLSALADLLLAETIRRVWPLVNRRPGAEPHLAVIAYGKLGGKELGYASDLDLVFLFDDDREDAAELYAKLGRRMTSWLSTMTSSGRLYEVDLRLRPDGDAGLLAVSLEAFEQYQRSHAWPWEHQALTRARYAAGDTEAGARFERIRADILVMPRDVQALRGEVLGMRDKISAGHPNRSELFDVKHDRGGMVDVEFVTQYLVLCHAATHRVLVNNLGNIALLRLAGEAGLIPAPLALAAGDAYRTLRRAQHQLRLKGVDKARVPPGQLAAERATVCELWQTVLQDGTIAQAEVK

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

941 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

104.312 kDa

MSSAPPFAAALAWSGHLRRRLDAHPDLAAWLANACAHPVSANVLAAWQAELSGPDAPEVLPVEQCRGMLRKLRERVFLTLIVRDLGGQADLEEVVGAMTVLADIAVGTAYRSVAAELAAVHGLPREQSTGDPQEMLIVGMGKLGGRELNVSSDIDLVMLYGDEGETDGPRRISNHEFYGRLTRRMMPALSEVDADGQVFRTDLRLRPDGDAGPLAWSLDALEHYLIGQGREWERYAWLKARLMPAQAFADSNPDAQARQLESLRVPFVYRKYFDFDALAALRALRERIRQDWQRRALARNGVDSANNIKLGDGGIREIEFIVQLSQLIRGGRMPALQRRGLLEALHAERAAGLVPEGDAQKLEAAYRFLRRTEHALQYREDEQTHLLPADPAQRAALAAALGYEPAAFERTLAEHRAFVSQTFRNAFRLAGMGEEDDSPAPARTHANGHAMRPHAGALHDIEERLAGQIQRDFPEHAEDLLRRTETLLGSHRVRSLPDSSRHRLEALLPAALTAAAQTSAPMDAALRLFDLIETIAQRSAYLALLAEYPDTLARVARMVAASPWAAQYLTQHPLLLDSLIDWRTLFEPLDFAQVAHQLAADLDACRLPDGEPDIERQMNLMRDVQRQASFQLLAQNLEGELTVEKLADQLSALADLLLAETIRRVWPLVNRRPGAEPHLAVIAYGKLGGKELGYASDLDLVFLFDDDREDAAELYAKLGRRMTSWLSTMTSSGRLYEVDLRLRPDGDAGLLAVSLEAFEQYQRSHAWPWEHQALTRARYAAGDTEAGARFERIRADILVMPRDVQALRGEVLGMRDKISAGHPNRSELFDVKHDRGGMVDVEFVTQYLVLCHAATHRVLVNNLGNIALLRLAGEAGLIPAPLALAAGDAYRTLRRAQHQLRLKGVDKARVPPGQLAAERATVCELWQTVLQDGTIAQAEVK

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

941 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

104.312 kDa

MSSAPPFAAALAWSGHLRRRLDAHPDLAAWLANACAHPVSANVLAAWQAELSGPDAPEVLPVEQCRGMLRKLRERVFLTLIVRDLGGQADLEEVVGAMTVLADIAVGTAYRSVAAELAAVHGLPREQSTGDPQEMLIVGMGKLGGRELNVSSDIDLVMLYGDEGETDGPRRISNHEFYGRLTRRMMPVLSEVDADGQVFRTDLRLRPDGDAGPLAWSLDALEHYLIGQGREWERYAWLKARLMPAQAFADSNPDAQARQLESLRVPFVYRKYFDFDALAALRALRERIRQDWQRRALARNGVDSANNIKLGDGGIREIEFIVQLSQLIRGGRMPALQRRGLLEALHAERAAGLVPEGDAQKLEAAYRFLRRTEHALQYREDEQTHLLPADPAQRAALAAALGYEPAAFERTLAEHRAFVSQTFRNAFRLAGMGEEDDSPAPARTHANGHAMRPHAGALHDIEERLAGQIQRDFPEHAEDLLRRTETLLGSHRVRSLPDSSRHRLEALLPAALTAATQTSAPMDAALRLFDLIETIAQRSAYLALLAEYPDTLARVARMVAASPWAAQYLTQHPLLLDSLIDWRTLFEPLDFAQVAHQLAADLDACRLPDGEPDIERQMNLMRDVQRQASFQLLAQDLEGELTVEKLADQLSALADLLLAETIRRVWPLVNRRPGAEPHLAVIAYGKLGGKELGYASDLDLVFLFDDDREDAAELYAKLGRRMTSWLSTMTSSGRLYEVDLRLRPDGNAGLLAVSLEAFEQYQRSHAWPWEHQALTRARYAAGDTEAGARFERIRADILVMPRDVQALRGEVLGMRDKISAGHPNRSELFDVKHDRGGMVGVEFVTQYLVLCHAATHRVLVNNLGNIALLRLAGEAGLIPAPLALAAGDAYRTLRRAQHQLRLKGVDKARVPPGQLAAERATVCELWQTVLQDGTIAQAEVK

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

941 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

102.806 kDa

MPMPTVSMSPALTALIERAVARVRQSLPVEQAWPGGEFDRQLAQVALASEFALDTLARQPALLQHLAQPDPPPLPLPQFDPAQPQLWPAQLRRYRSAESTRLVWRDVLGLDSVEATLAGATQLAEHCLQCGLQALEQQFHTRHGKVVAADGSVQRLVVFGLGKLGGGELNFSSDVDLVYAYPQGGQSDGARPLAAEEYFARLGQQLARLLDETTADGFSHRVDLRLRPFGTAGRVALSFAGMDQYFQREGRDWERYAWLKARAVAGDIDAGEAWLETLRPFVYRRYLDFTALDGLREMKAAITAEVARHDRLDDIKRGPGGIREIEFLAQSLQLIRGGREPSLRERRLLPALQALVAAGQIDQENGQALSTAYRFLRRLENRLQMLRDAQTHALPQAPLDRERIALGLGYAQWSALLDALAPQRARVAAEFAELLAPRVRATAPDALADYWRALPDGDAAPLAGIGLNDPDGAHRALADFAQSSGVRALSDSARARLDRVMPALLHAATRASQPDAAVRRMLGLLQATLRRTSYLALLDEQPSALARLVDVLSRSALLAERLAAYPLLLDELLDTRISGPLPDRAALHAACAHTLHIDDTEAALRELNERRLALSFRIALATLDGRQQAVESTRQLAWLAEAVVQTVLHLARSDMLAAHGHVPGGSFAIVGYGSLGGLELGFGSDLDLVFLYDHPREVDASDGKRPLDAGRWFARLAQKVMALLAAETGAGRLYDIDVRLRPDGGKGALVSSLASYREYQRDRAWTWEHQALVRARAVAGDAALCDAFAQVRRDTLMRVRDTAQLHEDVRKMRARMRAELDRSDAGRLDLKQGAGGLVDLEFVLQAGVLGLAAQQPQLLDACDTPALIDALARTHWLPDESAAPLHQAHATLVDAGLSCTLDRRPRLIAPTPAIQQARGIIFNAARGQGLTFPLGKDETAL

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

941 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

102.911 kDa

MSIPTASLSPALAALIERAVARVRQSLPAWQVWPGGDFDRQLAQVALASDFALDTLARQPALLQHLAHPDPPPLPLPQLDPAQPQLWPAQLRRYRSAESTRLVWRDVLGLDSVEATLAGATRLAEHCMQCGLQALEQQFATRHGKVIADDGSVQRLVVFGLGKLGGGELNFSSDVDLVYAYPQGGQSDGARSLAAEEYFARLGQQLARLLDEATAEGFSHRVDLRLRPFGTAGRVALSFAGMDQYFQREGRDWERYAWLKARAVAGAIDAGEAWLETLRPFVYRRYLDFTALDGLREMKAAITAEVARHDCLDDIKRGPGGIREIEFLAQSLQLIRGGREPSLRERRLLPALRALVTAGQIDQENGQALTTAYRFLRRLENRLQMLRDAQTHALPQAPLDRERIALGLGYAEWATLLDALAPQRARVTAEFAELLAPRVRATAPDTLADYWRALPAGDAARLAGMGLSDPGGAHQALADFAHSSGVRGLSDSARARLDRVMPALLHAATRASQPDAAVPRMLGLLQATLRRTSYLSLLDEQPSALARLVDVLSRSALLAERLAAYPLLLDELLDTRISGPLPDRAALHAACADIVHIDDTEAALRELNERRLARSFRIALATLDGRQQAVESTRQLAWLAEAVVQTVLHLARTEMVAAHGYVSGGSFAIIGYGSLGGMELGFGSDLDLVFLYDHPPEVDASDGKRPLEAGRWFARLAQKVMALLAAETGAGRLYDIDVRLRPDGGKAALVSSLASYREYQRERAWTWEHQALVRARAVAGDAVLCDAFAQVRRYTLMRVRDTAQLHEDVRKMRARMRTELDRSDAGRLDLKQGAGGLVDLEFVLQAGVLGLAAQQPQLLDVCDTPALIDALVQVHWLPDDSAASLHQAHATLVDAGLSCTLDRRPRLIAPTPAIQQARGTIFNAARVQRLTFPLGKDEAAL

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

938 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

105.278 kDa

MLEADAARLKTDRLGYNPLHVLRADAATRRQEPAILTMIRSSPPMSVDSSPLPEALRHAASISRFMRRMLDSRPWLAAQLAGSLGQPLDSEAMSSFLANRGVDEARLRASLRHLRSWVVCHVLTRDLNGFADLAEVTETMTVLAEVTVRATYEVLREGLVARYGAPLSPTGWEQELLVIGMGKLGGRELNVSSDIDLIFVYPEDGDTGGNKVISNFEFFERLGKQMIQALADVTEHGQVFRVDMRLRPNGDSGPLVCSFDMLENYFITQGREWERYAWIKARVLAGERYHELEQIARPFVFRKYLDFGSINAMRALHAQIRREVTRRDRVNNIKLGPGGIREIEFTAQVFQLIRGGREPGLQVRATLDVLAVLGERGILTPQTVGELAEAYDFLRRLEHRLQYLDDAQTHDLPGNDEDCECIARAMDFPDYTSFLGVLDHHRAAVSRHFDHVFGDPSEEAHTLDSMWAAARDVEQAEPILSRLGYGDPSGAAHRLAALHGSARYQQLPNHIRSRLDALMPRVVEVAAATPGPDETLARCIDLIEAISRRGAYLALLQQYPQALRRVADLVGASRWAAQYLTRHPILLDELLDDRNLEPAPDWDALRAQMRDTLDTLEPDMERQMDVMREQHHAQVFRLLTQDIAGLLTVEKLADHLSALADLMLELALPLVWRKIKIRHRDDPAFAVIAYGKLGGKELGYASDLDIVFLFDDPAPEALEVYTRLAQRINTWLSSQTAAGILFETDLRLRPNGESGLLVTSIESFRKYQLESAWVWEHQALTRARFAAGDATIGAAFERIRCEVLRLPRDIAALRAEVLAMRRKMSDAHAGKSERFNLKHDAGGLVDVEFLIQYLVLGHAHRYPELTGNLGNIALLRIAGELGLIPAELAARCGDSYRLFRRLQHRQRLNGLLSLVAPDEVAAAREPVRALWTIVFGSA

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

938 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

105.278 kDa

MLEADAARLKTDRLGYNPLHVLRADAATRRQEPAILTMIRSSPPMSVDSSPLPEALRHAASISRFMRRMLDSRPWLAAQLAGSLGQPLDSEAMSSFLANRGVDEARLRASLRHLRSWVVCHVLTRDLNGFADLAEVTETMTVLAEVTVRATYEVLREGLVARYGAPLSPTGWEQELLVIGMGKLGGRELNVSSDIDLIFVYPEDGDTGGNKVISNFEFFERLGKQMIQALADVTEHGQVFRVDMRLRPNGDSGPLVCSFDMLENYFITQGREWERYAWIKARVLAGERYHELEQIARPFVFRKYLDFGSINAMRALHAQIRREVTRRDRVNNIKLGPGGIREIEFTAQVFQLIRGGREPGLQVRATLDVLAVLGERGILTPQTVGELAEAYDFLRRLEHRLQYLDDAQTHDLPGNDEDCECIARAMDFPDYTSFLGVLDHHRAAVSRHFDHVFGDPSEEAHTLDSMWAAARDVEQAEPILSRLGYGDPSGAAHRLAALHGSARYQQLPNHIRSRLDALMPRVVEVAAATPGPDETLARCIDLIEAISRRGAYLALLQQYPQALRRVADLVGASRWAAQYLTRHPILLDELLDDRNLEPAPDWDALRAQMRDTLDTLEPDMERQMDVMREQHHAQVFRLLTQDIAGLLTVEKLADHLSALADLMLELALPLVWRKIKIRHRDDPAFAVIAYGKLGGKELGYASDLDIVFLFDDPAPEALEVYTRLAQRINTWLSSQTAAGILFETDLRLRPNGESGLLVTSIESFRKYQLESAWVWEHQALTRARFAAGDATIGAAFERIRCEVLRLPRDIAALRAEVLAMRRKMSDAHAGKSERFNLKHDAGGLVDVEFLIQYLVLGHAHRYPELTGNLGNIALLRIAGELGLIPAELAARCGDSYRLFRRLQHRQRLNGLLSLVAPDEVAAAREPVRALWTIVFGSA

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

937 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

102.203 kDa

MSQPIPSASPALAALIERAVARVRHALPADAPWPEGVEHPLARVALASDFVVDTLARQPALLAHLAQPDPPPLPVPRLDPAQPQEWAAQLRRYRAAASARLVWRDVLGLDDVDATLAGATTLAETCLQCALQALEQQFSTRHGQVIAEDGSVQRLVVFGLGKLGGGELNFSSDVDLVYAYPQAGQSDGARPLAAEEYFARLGQQLARLLDETTADGFSHRVDLRLRPFGSAGRVALSFNGMDQYFQREGRDWERYAWLKARAVAGDIAAGEAWLETLRPFVYRRYLDFTALDGLRDMKAAITAEVAHHARLDDIKRGPGGIREIEFLAQSLQLIRGGREASLRERRLLPALQALVDLGQIDPPTGQALADAYRFLRRVENRLQMLRDAQTHALPQGEPERERIALGLGYAHWQALLEALAPHRTRVAAEFAELLAPRVHATAPDTLADYWRALPEGDAAPLLGIGLHDPNNAHHMLADFAQSSGVRALSDGARTRLDRVMPALLHAAIRATQPDAALRRVLGLLQATLRRTSYLALLDEQPSALARLVDVLSRSALLAERLAAYPLLLDELLDTRISGPLPDRAALHTACVDTLQIDDTEAALRELNERRLALSFRIALATLDGRQQPVDSTQQLAWLAEAVVQTVLQLARRELVAAHGQVPGGAFAIIGYGSLGGLELGFGSDLDLVFLYDHPREVEASDGKRPLEAGRWFARLAQKVMTLLGAETGAGRLYDIDVRLRPDGGKGALVSSLASYRDYQRDRAWTWEHQALVRARAVAGDAALCEAFVQVRRETLTRVRDPALLHEDVRKMRARMRSELDRSDAGRLDLKQGAGGLVDLEFLLQAGVLGQAAQHPALLLACATPALIDALVQVQWLPAESAAPLHHAHATLVEAGLSCTLDRRPRLVVSTPPIRDACQIVAAIADAQQLRFQPGKGA

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

937 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

102.253 kDa

MSQPIPSASPALAALIERAVARVRHALPADAPWPEGLEHPLARVALASDFVVDTLARQPALLAHLAQPDPPPLPVPRLDPAQPQEWAAQLRRYRAAASARLVWRDVLGLDDVDATLAGATMLAETCLQCALQALEQQFATRHGQVIAEDGSVQRLVVFGLGKLGGGELNFSSDVDLVYAYPQAGQSDGARPLAAEEYFARLGQQLAKLLDETTADGFSHRVDLRLRPFGSAGRVALSFNGMDQYFQREGRDWERYAWLKARPVAGDIAAGEAWLETLRPFVYRRYLDFTALDGLRDMKAAITAEVARHARLDDIKRGPGGIREIEFLVQSLQLIRGGREASLRERRLLPALQALVDLGQIDPPTGQALAEAYRFLRRVENRLQMLRDAQTHALPQGEPERERIALGLGYAHWQALLEALAPHRTRVAAEFAELLAPRVHATAPDTLADYWRALPEGDAAPLLGIGLHDPNNAHHMLADFAQSSGVRALSDGARTRLDRVMPALLHAAIRATQPDAALRRVLGLLQATLRRTSYLALLDEQPSALARLVDVLSRSALLAERLAAYPLLLDELLDTRISGPLPDRAALHTACVDTLQIDDTEAALRELNERRLALSFRIALATLDGRQQPVDSTQQLAWLAEAVVQTVLQLAQTQLQAAHGQVPGGAFAIIGYGSLGGMELGFGSDLDLVFLYDHPREVEASDGKRPLEAGRWFARLAQKVMTLLGAETGAGRLYDIDVRLRPDGGKGALVSSLASYRDYQRDRAWTWEHQALVRARAVAGDAALCEAFVQVRRETLTRVRDPALLHEDVRKMRARMRSELDRSDAGRLDLKQGAGGLVDLEFLLQAGVLGQAAQHPALLLACATPALIDALVQVQWLPAESAAPLHHAHATLVEAGLSCTLDRRPRLVVSTPPIRDACQIVAAIADAQQLRFQPGKGA

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

937 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

102.203 kDa

MSQPIPSASPALAALIERAVARVRHALPADAPWPEGVEHPLARVALASDFVVDTLARQPALLAHLAQPDPPPLPVPRLDPAQPQEWAAQLRRYRAAASARLVWRDVLGLDDVDATLAGATTLAETCLQCALQALEQQFSTRHGQVIAEDGSVQRLVVFGLGKLGGGELNFSSDVDLVYAYPQAGQSDGARPLAAEEYFARLGQQLARLLDETTADGFSHRVDLRLRPFGSAGRVALSFNGMDQYFQREGRDWERYAWLKARAVAGDIAAGEAWLETLRPFVYRRYLDFTALDGLRDMKAAITAEVAHHARLDDIKRGPGGIREIEFLAQSLQLIRGGREASLRERRLLPALQALVDLGQIDPPTGQALADAYRFLRRVENRLQMLRDAQTHALPQGEPERERIALGLGYAHWQALLEALAPHRTRVAAEFAELLAPRVHATAPDTLADYWRALPEGDAAPLLGIGLHDPNNAHHMLADFAQSSGVRALSDGARTRLDRVMPALLHAAIRATQPDAALRRVLGLLQATLRRTSYLALLDEQPSALARLVDVLSRSALLAERLAAYPLLLDELLDTRISGPLPDRAALHTACVDTLQIDDTEAALRELNERRLALSFRIALATLDGRQQPVDSTQQLAWLAEAVVQTVLQLARRELVAAHGQVPGGAFAIIGYGSLGGLELGFGSDLDLVFLYDHPREVEASDGKRPLEAGRWFARLAQKVMTLLGAETGAGRLYDIDVRLRPDGGKGALVSSLASYRDYQRDRAWTWEHQALVRARAVAGDAALCEAFVQVRRETLTRVRDPALLHEDVRKMRARMRSELDRSDAGRLDLKQGAGGLVDLEFLLQAGVLGQAAQHPALLLACATPALIDALVQVQWLPAESAAPLHHAHATLVEAGLSCTLDRRPRLVVSTPPIRDACQIVAAIADAQQLRFQPGKGA

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

931 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

100.813 kDa

MTLAPADLPASLQPLVDRALARLAQVLPEPIPANLLPLLTRLAVTSDFALDTLVRQPALLAQLAAPGCPPIPAPVLDPLQPSDWPAQIRRWRTAMSTRLIWRDLTGLDDVAQTLAGATALAEDCLRLALDALQQEFAQRHGVIADEHGIPQQLVVFGLGKLGGGELNFSSDVDLVYAYPQGGESDGPRPLAAEEYFARLGQRLAKLLDETTVDGFSHRVDLRLRPFGSAGRVALSFAAMDQYFQREGRDWERYAWLKARAVAGDIEAGEAWLQTLRPFVYRRYLDFTALDGLREMKAAITAEVARRELHDDIKRGAGGIREIEFLCQALQLIRGGREPALRERRLLVALDALVAAGQIAPEDGSALREAYLFLRRLENRLQMLRDAQTHVLPSDALDRERIAVGLGYPDWEVLRAALAVQQQRVSTEFAALLAPRKGQAAPDALANYWRSLPEGSNAPLLAEAGFLDANGADQSLRDFAQGTGVKSLSDAARARLDRVLPALLHAATRSPQPDAALKRVLGLLQAVLRRTSYLALLDEQPSALARLVDVLARSALLAERLAAYPLLLDELLDVRVSGPMPDAAGMLAECQQVLAVEDPESALRWLNETRLALSFRMAMATLDGRQGAVDSTRQLAELAQAVVVTVLAMAEADMHAAHGEIPGGRFAIIGYGSLGGLELGFGSDLDLVFLHDNPAGVDASDGARPLEPGRWYARLAQKVMALLGAVTAAGRLYDIDVRLRPDGGKGSLVSSLASYTEYQRERAWTWEHQALVRARGVAGDASLLADFEQVRAQTLGRERDTGVLYADVLKMRGRMRTELDRSDAARLDLKQGAGGVVDLEFLLQTGVLARSARHAALLQPRDTPSLIDALAVAEFLPEDTAQALHGAHATLLDVGLACTLDRRPRLAPTTPAIEEACAAITAACIAAELPFA

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

931 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

100.52 kDa

MTLAPADLPVSLQPLVDRALARLAQVLTEPIPADLLPLLTRLAVASDFALDTLVRQPALLAQLAAPGCPPIPAPVLDPLQPSDWPAQLRRWRAAMSTRLIWRDLAGLDDVAQTLAGATTLAEDCLRLALEALQQEFAQRHGVIADDQGTPQQLVVFGLGKLGGGELNFSSDIDLVYAYPHGGESDGPRALAAEEYFARLGQRLAKLLDETTVDGFSHRVDLRLRPFGSAGRVALSFAAMDQYFQREGRDWERYAWLKARAVAGDIAAGEAWLQTLRPFVYRRYLDFTALDGLREMKAAITAEVARRELHEDIKRGAGGIREIEFLCQALQLIRGGREPALRERRLLVALDALVAAGQIAPEDGSALREAYLFLRRLENRLQMLRDAQTHVLPSDALDRERIAVGLGYADWNVLRAALAEQQQRVSTEFAALLAPRKGQAAPDALANYWRSLPEGSNAPLLAEAGFLDANGADQSLRDFAQGTGVKSLSDAARARLDRVLPALLHAATRSPQPDAALKRVLGLLQAVLRRTSYLALLDEQPSALARLVDVLARSALLAERLAAYPLLLDELLDVRVSGPMPDAAGMLAECQQVLAVEDPESALRWLNETRLALSFRMAMATLDGRQGAVDSTRQLAELAQAVVVTVLAMAEADMHAAHGGIPGGRFAIIGYGSLGGLELGFGSDLDLVFLHDNPAGVDASDGARPLEPGRWYARLAQKVMALLGAVTAAGRLYDIDVRLRPDGGKGSLVSSLASYTEYQRERAWTWEHQALVRARGVAGDASLLADFEQVRAQTLGRERDTGVLYADVLKMRGRMRTELDRSDAARLDLKQGAGGVVDLEFLLQTGVLARSAQHAALLQPRDTPSLIDALAVAGFLPDATAQALHGAHATLLDVGLACTLDRRPRLAPTTPAIEEACAAITAACRAAELPFA

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

929 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

106.389 kDa

MTTPISTSRAASIVSSILPYSRYLKRVLENESELQQELLEQLHNPFTREEMLGFLQDSTAHLIDEADLHRLLRQLRKRVILRLAARDLAGLADLNEVMATMTALADVTIQFSLEFLHAAMVQPGHFGKPKGEKTGTEQQLLIVAMGKLGGGELNVSSDVDLVFIYPEDGETDGSKSITNHEFFLRLGRKLIASLNDYTVDGYVFRVDMRLRPYGENSPLAISLPMLEDYFVTQGREWERHAWIKSRVITGSSIAEAALMELIVRPFVFRKYLDFEAYEAMRSLHTQLRKEVDRRELHDNIKLGPGGIREIEFITQVFQLIRGGRDADLCIRPTLGVLQRLKQKQPLPEQTVEELIEAYYFLRKLEHRLQYLDDQQTQNLPQHSDDQILIAKSMGFTDYTGFLKHLDLHRQNVTRHFEQIFAVRRKAIKLGTFARIRPEQTNDNEIVKVFSNQLKTLGYIDPDKITARVQQFYDGTTFRQLSHPNQERILELMPTLMEVVTRFPPVEITLERMLRLLEKIGQYSAYLALLQEYPQTLPRVAKLVSISQWASDYLGSHPILLDELLAPSGLHTLPDWPTLKTELIHQLHHGNIPKAQIIEWQMDVLRHFQHAQVFRLLAVDLEGNLLLETLSDHLTALADLILDNVLQLAWQGLKKKHRKSPAFAIIGYGKLGGKELGYVSDLDIVYLYQDNHPDAMEIYTKLAQNINLWLTSHTSAGVLYETDLRLRPNGTSGLLVNSIEAFSLYQHEQAWVWEHQALTRARFVIGDSEVGEKFEQMRKNILCQPRDMENLKREILMMRTKMLEAHPNSTPLFDVKHDHGGIIDVEFIVQYLVLGYAHRYPQLTSNIGNIALLKLAGELGLTSAEKANAAFIAYRELRRTQHQLRLSGIPEATGTALPKDVSQKFARVTSDYLSSARRAVFQLWEDVFGT

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

929 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

106.323 kDa

MSTPIDSSRAASIVASILPYSRYLKRTLASEPGLQQELLDQLPNPFLWEEMLDFLQHPAISLEDEADLHRLLRQLRKRVILRLAARDLAGLADLNEVMTTMTALADTTIRFALEFLHTAMTHPGHFGKPTGEKTGTEQQLLIVAMGKLGGGELNVSSDVDLIFIYPEDGETDGRKSITNHEFFVRLGRKLIASLSDYTVDGYVFRVDMRLRPHGENSPLAISLPMLEDYFITQGREWERHAWIKSRVITGSSVAEATLMELIVRPFVFRKYLDFEAYEAMRSLHAQLRKEVDRRELHDNIKLGPGGIREIEFITQVFQLIRGGRDADLCIRPTLGVLRRLRQKQPLPGQTIEELTEAYCFLRKLEHRLQYLDDQQTQNLPQHPDEQTLIARSMGFTGYGDFLDHLDLHRQNVTRHFEQIFAARRKSPRHDTFARIRPEQSGDHETVEAFSKQLQTLGYLDPGKITARVRQFYDSTFFRQLTHSSQERIFELMPTLMEVIARFPPVDITLERILRLLEKIGQYPAYLALLQEHPQTLPRVAKLASVSQWASDYLGRHPILLDELLTSSGLHILPDWPALKTELTHQLHHVNIPKVQMVEWQMDVLRHFQHAQVFRLLVTDLEGDLLLEKLSDHLTELADLILDNVLQLAWQGLKKKHRELPAFAIIGYGKLGGKELGYASDLDIVFLYRDDHPDAASIYTKLAQNINLWLTSHTSAGILYETDLRLRPNGTSGLLVNSIEAFTQYQYEQAWVWEHQALTRARFVVGDREAGEMFEQMRKNMLCQPRDLVKLKREILMMRSKMLEAHPNPTPLFDIKHDRGGIIDVEFIVQYLVLGYAHRYPQLTGNIGNIALLKLAGELGLTSAGKATAALTAYRELRRTQHQLRLSGTPEPAGTALSRDVSQKFARVANNHLSDARQAVFQLWEDIFGT

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

927 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

102.397 kDa

MTMTDASDLLSLSYSHYLARAAAARPALAERIAAWAAAPVTRAALDARLDELLAQGGQPPSEDALKKALRQLRGEAFGAVAERDLAGRADVAEVTGTMTDLAEAAIQRALALLAAELEAQYGEPRGPSGERLALGVVGMGKLGGRELNVSSDIDLIFVYEDDGETAGGARGPISVHEFFTRLGRRLIGVLSEATADGYVFRVDMRLRPNGDSGPLVCSLGMLEEYFYVQGREWERYAWIKGRLVTERASAAARRLAQQLDAIVKPFVYRRYLDFGVIGAIRSLHEQIRQEARRRATMRPDKADDIKLGRGGIREIEFSAQVFQLIRGGQDAGFRVQPTLAVLRHASASGLITEEVRAGLTHAYLFLRTLEHRLQYRNDAQTHAMPVDPAERAALAASLGFADYAALIDRLDQHRAFVEAQFDQVFADKADGGARREDDQAAGCIWSGALADDGADEALVARLAELGFADPAAVLARLQAVWRSSRYAGLPESSRVRFDRVAHRALEAAPGIDAAHRDETVVRCFDLLETVGRRGAYLALLTEYPAALRRVLSVLGATRWGGGYLIRHPQLLDELLDDEAIDSPFDWPAFKDALRRRLAAADGAEHQMDLLRHAHQAEVFRILLLDLAGRLSVEHVSDRLSELADAMLDVTIEVVWSQLAKRHRDTPCFAAIAYGKLGGKELGYASDLDLIFLYDDPDERAADVYTTFARRLITWLTTATGAGTLFDIDLRLRPNGEAGLLVTDLDAFRRYQLREGDAANTAWVWEHQALTRARYSAGDARIGAAFEAIRVQVLTTPRDAAVLAREIVEMREKVLAGHPNTTERFDLKHDRGGMVDIEFAVQYWVLLHAARHPEMIRNTGNIALLREVSRFGLMSEEEAETVGAAYRTYRKLQHRLRLDGMEKARVEPERVAAERQAVAALWARVFGA

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

925 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

102.151 kDa

MTDASDLLSLSYSHYLARAAAARPALAERIAAWAAAPVTRAALDARLDELLAQGGQPPSEDALKKALRQLRGEAFGAVAERDLAGRADVAEVTGTMTDLAEAAIQRALALLAAELEAQYGEPRGPSGERLALGVVGMGKLGGRELNVSSDIDLIFVYEDDGETAGGARAPISVHEFFTRLGRRLIGVLSEATADGYVFRVDMRLRPNGDSGPLVCSLGMLEEYFYVQGREWERYAWIKGRLVTERASAAARRLAQQLDAIVKPFVYRRYLDFGVIGAIRSLHEQIRQEARRRATMRPDKADDIKLGRGGIREIEFSAQVFQLIRGGQDAGFRVQPTLAVLRHASASGLITEEVRAGLTHAYLFLRTLEHRLQYRNDAQTHAMPVDPAERAALAASLGFADYAALIDRLDQHRAFVEAQFDQVFADKADGGARREDDQAAGCIWSGALADDGADEALVARLAELGFADPAAVLARLQAVWRSSRYAGLPESSRVRFDRVAHRALEAAPGIDAAHRDETVVRCFDLLETVGRRGAYLALLTEYPAALRRVLSVLGATRWGGGYLIRHPQLLDELLDDEAIDSPFDWPAFKDALRRRLAAADGAEHQMDLLRHAHQAEVFRILLLDLAGRLSVEHVSDRLSELADAMLDVTIEVVWSQLAKRHRDTPCFAAIAYGKLGGKELGYASDLDLIFLYDDPDERAADVYTTFARRLITWLTTATGAGTLFDIDLRLRPNGEAGLLVTDLDAFRRYQLREGDAANTAWVWEHQALTRARYSAGDARIGAAFEAIRVQVLTTPRDAAVLAKEIVEMREKVLAGHPNTTERFDLKHDRGGMVDIEFAVQYWVLLHAARHPEMIRNTGNIALLREVSRFGLMSEEEAETVGAAYRTYRKLQHRLRLDGMEKARVEPERVAAERQAVAALWARVFGA

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

924 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

106.154 kDa

MQTKGCRFFMNTEQLQKTLRSSQYAEQVLGLHQLYLEQDYQIDQFAAPLSRENIFQSVENELKDIQDESQWMRVVRILRARLMFRWIWQDANRLTNVVSLTRELSDFADACICAAKQFARAPLVAKHGEPVGYDGQIQDLIVIGMGKLGAQELNLSSDIDLIFAYDEQGETNGRKSIDVQQFCILWGQKLIYLLDHITADGFVFRVDMRLRPWGDGSALAISHMALEKYLIQHGREWERYAWIKARIISGGKHGDDLLEMTRPFVFRRYVDYSAFAAMREMKSMIEREVARRNIADDIKLGAGGIREVEFIVQVFQLIYGGSKRELQDRQCLVSLNHLGQAGLLQSQDVIELEDAYLFLRRVEHAIQALNDQQTQMLPMEPELRQRILDTLEYPTWDNFIEALNEKRHKVSEQFKKLIQEEVTSPDETDTELEQQLNAILDETAQNLVHEFWQSNALKRLPSKAVQRLKDFWPHFIEAILQSEHPQMAFMRLMPLIESVMRRTVYLVMLMESRGAMQRLVKMATVSPWICEELTQYPVLLDEFLSMDFELPQRKDLEDSLRQQLLRIEIDQVEDQMRVLRLFKKSNVLTVAASDVLAESPLMKVSDALTDIAEVSVAATLNLAYQAVVKKHGYPKDASGERCSLEHTGFAVIGYGKLGGIELGYGSDLDLVFIHYFDEQAETDGSKSITGFEFAMRVAQKFLSLMTTQTLDGRVYEIDTRLRPSGEAGLLVTSLKAFEQYQLKSAWLWEHQALVRARSIAGEAQLRQKFESLRCQILTQSRDENEVRDEVLKMRQKMKDHLGSSNEQKKHGIFHLKQDAGGIVDIEFMAQYMVLAWSGANPDLAHFSDNVRILEDAAQAGCLSSEDATALMHAYLRERAESHRLALANQSMQVNAAQWRHTREVVCKLWQRLIDPASTMALESE

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

924 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

106.154 kDa

MQTKGCRFFMNTEQLQKTLRSSQYAEQVLGLHQLYLEQDYQIDQFAAPLSRENIFQSVENELKDIQDESQWMRVVRILRARLMFRWIWQDANRLTNVVSLTRELSDFADACICAAKQFARAPLVAKHGEPVGYDGQIQDLIVIGMGKLGAQELNLSSDIDLIFAYDEQGETNGRKSIDVQQFCILWGQKLIYLLDHITADGFVFRVDMRLRPWGDGSALAISHMALEKYLIQHGREWERYAWIKARIISGGKHGDDLLEMTRPFVFRRYVDYSAFAAMREMKSMIEREVARRNIADDIKLGAGGIREVEFIVQVFQLIYGGSKRELQDRQCLVSLNHLGQAGLLQSQDVIELEDAYLFLRRVEHAIQALNDQQTQMLPMEPELRQRILDTLEYPTWDNFIEALNEKRHKVSEQFKKLIQEEVTSPDETDTELEQQLNAILDETAQNLVHEFWQSNALKRLPSKAVQRLKDFWPHFIEAILQSEHPQMAFMRLMPLIESVMRRTVYLVMLMESRGAMQRLVKMATVSPWICEELTQYPVLLDEFLSMDFELPQRKDLEDSLRQQLLRIEIDQVEDQMRVLRLFKKSNVLTVAASDVLAESPLMKVSDALTDIAEVSVAATLNLAYQAVVKKHGYPKDASGERCSLEHTGFAVIGYGKLGGIELGYGSDLDLVFIHYFDEQAETDGSKSITGFEFAMRVAQKFLSLMTTQTLDGRVYEIDTRLRPSGEAGLLVTSLKAFEQYQLKSAWLWEHQALVRARSIAGEAQLRQKFESLRCQILTQSRDENEVRDEVLKMRQKMKDHLGSSNEQKKHGIFHLKQDAGGIVDIEFMAQYMVLAWSGANPDLAHFSDNVRILEDAAQAGCLSSEDATALMHAYLRERAESHRLALANQSMQVNAAQWRHTREVVCKLWQRLIDPASTMALESE

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

896 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

102.035 kDa

MSDNRLDTARHHSLFLARQLDNGKLKPEIFLPMLDKVLTEADFQAFADWDKIRAEENEEELARQLRELRRYVVSQIIVRDINRISDLNEVTRTITLFADFAVNTALDFAYAYYRDMYGTPIGRYTKSPQHLSVVAMGKAGGYELNVSSDIDLIFVYPESGDTDGRRERGNQEFFTKVGQKLIALLNDITADGQVFRVDMRLRPDGDSGALVLSETALEQYLITQGREWERYAWCKGRVVTPYPNGIKSLVRPFVFRKYLDYSAYEAMRKLHRQISSEVSKKGMADNIKLGAGGIREVEFIAQIFQMIRGGQMRALQLKGTQETLKKLAETGIMPSENVETLLAAYRFLRDVEHRLQYWDDQQTQTLPTSPEQRQLLAESMGFDSYSAFSDGLNIHRNKVNQLFNEILSEPEEQTQDNSEWQWAWQEKPDEEERLGRLKEYGFDAETIATRLDQIRNGHKYRHLSAHAQPRFDAIVPLFVQAAAEQNNPTDTLMRLLDFLENISRRSAYLAFLNEHPQTLAQLAQIMGQSSWVAAYLNKYPILLDELISAQLLDTAFDWQALAAALSDDLKACGGDTEAQMDTLRRFQHAQVFRLAVQDLAGLWTVESLSDQLSALADTILAAALLCAWADMPKKHRDTPQFAIVGYGKLGGKELGYASDLDLVYLYDDPHPDAGDVYSRLARRLTNWLSTATGAGSLYETDLRLRPNGDAGFLAHSIAAFEKYQRENAWTWEHQSLTRARFICGTPEIQTAFDRIRTEILTAERDQTALSGEIIEMREKMFPTHPPADSNVKYARGGVVDVEFIVQYLILAHARQYPQLLDNYGNIALLNIAADCGLIDKTLAGQSRTAYRFYRRQQHNTKLRDAKKTEVTGELLAHYGNVRKLWREVFGEEAATA

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

896 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

101.762 kDa

MSDNRLDTARRHSLFLARQLDNGKLKPEIFLPMLDKVLTEADFQAFADWGEIRAEENEEELARQLRELRRYVVSQIIVRDINRISDLNEVTRTITLFADFAVNTALDFAYAYYRDMYGTPIGRYTKSPQHLSVVAMGKAGGYELNVSSDIDLIFVYPESGDTDGRRERGNQEFFTKVGQKLIALLNDITADGQVFRVDMRLRPDGDSGALVLSETALEQYLITQGREWERYAWCKGRVVTPYPNDIKALVRPFVFRKYLDYGAYEAMRKLHRQISSEVSKKGMADNIKLGAGGIREVEFIAQIFQMIRGGQMRALQLKGTQETLKKLAELGIMLSEHVETLLAAYRFLRDVEHRLQYWDDQQTQTLPTSPEQRQLLAESMGFDSYSAFSDGLNVHRNKVNQLFNEILSEPEEQTQDNSEWQWAWQDKPDEEGRRCRLKAHGFDAETVAARLDQIRHGHKYRHLSAHAQPRFDAVVPLFVQAAAAQSNPTDTLMRLLDFLENISRRSAYLAFLNEHPQTLAQLAQIMGQSSWVAAYLNKYPILLDELISAQLLDTAFDWQALAAALSDDLKACGGDTEAQMDTLRRFQHAQVFRLAVQDLAGLWTVESLSDQLSALADTILAAALLCAWADMPKKHRDTPQFAVVGYGKLGGKELGYASDLDLVYLYDDPHPDAGDVYSRLARRLTNWLSAATGAGSLYETDLRLRPNGDAGFLAHSIAAFEKYQRENAWTWEHQSLTRARFICGTSEIQTAFDRIRTEILTAERDQTALAGEIIEMREKMFPTHPPADSNVKYARGGVVDVEFIVQYLILAHARQYPQLLDNYGNIALLNISADCGLIDKTLAGQSRTAYRFYRRQQHNTKLRDAAKTEVTGELLAHYGNVRKLWREVFGEEAATV

glnE

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

894 amino acids

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Belongs to the GlnE family.

99.843 kDa

MPANTSAAIARSCEFSQYLHRLLTARPEERQRLEQSLHHPFSLEDMQAFADWPALDAPEALAPALRRLRQAVVARLICRDLESLATLDEVVSTISQLAEFAVRQALACAAASLPQYGRPIGEDSGEPQQLIVIGMGKLGGGELNVSSDIDLIFIYPEGGETDGARKISNHEYFTQVGKRLIALLNDATADGQVFRVDMRLRPYGDSGPLVMSFAALENYLLSQGREWERYAWIKAKAITGDADGLAQLVRPFVYRKYLDYNAYGAMRGLHAQIRREVARRDMADNIKLGPGGIREAEFIAQVFQLIRGGRDRTLQLRGTRATLERLAALRLLEPAAVAELQASYAFLRNLEHRLQYLDDQQTQTLPEAPETRQKIAASMGHADWPAFLDALNEVRRKVSRHFEQVFILPSEDSASHPLSELWLDVAEQSPETRLAELGYADPAAVARQLTGLAQSQRYLQMPLAGRKQLDALMPALIEVAARFPNADDTLSRIIGLMEAISRRASYLALLTEYPQTLQRLASLYSSSAWVSAYLSRHPILLDELLDARMLYAAPDWPLLAAQLETQLAQADGDVEAKMDALRHFQHAQTFRLVAQDLAGMWTLEALSDELSRLADLVLAAAVRHAWRDIPSRHCETPRFAVIGYGKLGGKELGYASDLDIIFLYDDEHPDAPDLYSRLARKLSTWLTSATAAGVLYDIDLRLRPNGSSGLLVSSISAFRQYQENQAWVWEHQALTRARFVAGDAGIGSQFEAERHAILTLERDPAKLRDEVMAMRQRMLDSHPAHDGDVKNARGGIIDIEFIVQYLILAHAKTLPALTGNTGNIALLAVAAEAGLIDRRLAEDARAAYRLYRRLQHSARLNDRKTVEVDESLRTAYARGRELWRQVFEQALDFS