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ghoT

Gene
ghoT
Protein
Toxin GhoT
Organism
Escherichia coli O157:H7
Length
57 amino acids
Function
Toxic component of a type V toxin-antitoxin (TA) system. Causes membrane damage when induced by MqsR, slowing cell growth and leading to the formation of dormant persister cells; involved with GhoS, its antitoxin, in reducing cell growth during antibacterial stress. Its toxic effects are neutralized by GhoS, which digests ghoT transcripts in a sequence-specific manner.
Similarity
Belongs to the GhoT/OrtT toxin family.
Mass
6.555 kDa
Sequence
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Gene
ghoT
Protein
Toxin GhoT
Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Length
57 amino acids
Function
Toxic component of a type V toxin-antitoxin (TA) system. Causes membrane damage when induced by MqsR, slowing cell growth and leading to the formation of dormant persister cells; involved with GhoS, its antitoxin, in reducing cell growth during antibacterial stress. Its toxic effects are neutralized by GhoS, which digests ghoT transcripts in a sequence-specific manner.
Similarity
Belongs to the GhoT/OrtT toxin family.
Mass
6.555 kDa
Sequence
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Gene
ghoT
Protein
Toxin GhoT
Organism
Escherichia coli (strain K12)
Length
57 amino acids
Function
Toxic component of a type V toxin-antitoxin (TA) system. Causes membrane damage when induced by MqsR, slowing cell growth and increasing the formation of dormant persister cells; involved with GhoS, its antitoxin, in reducing cell growth during antibacterial stress (PubMed:24373067). Overexpression causes cell lysis, forming ghost cells; both effects are neutralized by expression of GhoS. Overexpression in the presence of ampicillin increases persister cell formation (persister cells exhibit antibiotic tolerance without genetic change) (PubMed:22941047). Overexpression causes about 90-fold reduction in cellular ATP levels and dissipates the membrane potential (PubMed:24373067).
Similarity
Belongs to the GhoT/OrtT toxin family.
Mass
6.555 kDa
Sequence
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF