Function
As part of a cytosolic protein quality control complex, the bag6/bat3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The bag6/bat3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Similarly, the bag6/bat3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum. The bag6/bat3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome.
Sequence
MAAAMAEQEGSKGSARNRGGVQRVEGKLRASVEKGDYYEAHQMYRTLFFRYMSQSKHIEARELMYSGALLFFSHSQRNSAADLSMLVLESLEKHEVKVTEELLENLAKLFSLMDPNSPERVAFVSRALKWSTGGSGKFGDPKLHQFLAITLWKEQNYYESRYHFLHSSDGEGCANMLVEYSSSRGYRSEVDMFVVQAVLQFLCLKNKTSASVVFTTYTQKHPSIERGPPFVQPLLNFIWFLLLAVEGGKLTVFTVLCEQYQPSLKRDPMYNEYLDRIGQLFFGLPPKQSSSYGGLLGNLLNSLMGSGEDDDVEDGQEDSSPIELD