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gep4

Gene
gep4
Protein
Probable phosphatidylglycerophosphatase, mitochondrial
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
209 amino acids
Function
Phosphatidylglycerophosphatase involved in the biosynthesis of cardiolipin (CL), a unique dimeric phosphoglycerolipid predominantly present in mitochondrial membranes and which has important functions for cellular energy metabolism, mitochondrial dynamics and the initiation of apoptotic pathways.
Similarity
Belongs to the GEP4 family.
Mass
23.992 kDa
Sequence
MLINIEGIQAFCQTIRNPRRIIPHATFPTFSQIPCNINYFLEQKFQVPVDIRALVLDKDNCITLPNETTIAEAELKKIREFQNIYGEKNVILLSNSIGTRKLDPTGELAAHFQQKWNIPVVRHSKLKPLCTEELYTYLSNNSHVSSASQILFIGDRLLTDITLANIMGSWGVWLTRGVGNTTNMMMEVESWLYKRIHTQNPYIPTNRKS

Gene
GEP4
Protein
Phosphatidylglycerophosphatase GEP4, mitochondrial
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
185 amino acids
Function
Phosphatidylglycerophosphatase involved in the biosynthesis of cardiolipin (CL), a unique dimeric phosphoglycerolipid predominantly present in mitochondrial membranes and which has important functions for cellular energy metabolism, mitochondrial dynamics and the initiation of apoptotic pathways. Required for the stability of respiratory chain supercomplexes and for growth at elevated temperature, in presence of ethidium bromide or in absence of prohibitins.
Similarity
Belongs to the GEP4 family.
Mass
20.945 kDa
Sequence
MNISGTLNTLRLLYNPSLCKPSLVVPTFNDLPIPIHDSIKAVVLDKDNCIAFPHDDKIWPDYLQHWETLRSKYSNKALLIVSNTAGSNSDKDYSQAKLLEDKTGIPVLRHSTKKPGCHNEILDYFYRNKTITNPKEVAVVGDRLFTDILMANLMGSYGVWIRDGVKVSANPLSKFEKKLYNFLGF