gcy-8

Gene

gcy-8

Protein

Receptor-type guanylate cyclase gcy-8

Organism

Caenorhabditis elegans

Length

1152 amino acids

Function

Guanylate cyclase involved in the production of the second messenger cGMP (PubMed:27062922). Regulates thermotaxis responses in AFD sensory neurons (PubMed:16415369, PubMed:21315599, PubMed:27062922). May regulate AFD neuronal activity such as calcium responses to temperature gradients (PubMed:16415369, PubMed:21315599). Maintains the microvilli receptive ending morphology of the AFD thermosensory neurons by regulating cGMP levels downstream of kcc-3 (PubMed:27062922). cGMP levels antagonize the actin cytoskeleton regulator wsp-1 (PubMed:27062922).

Similarity

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Mass

129.07 kDa

Sequence

MRTKKAFLLLTFNVLIYLAACQETERILANNGTEDNEITTSKGVSPNTNPLFLSNSTAGLYDSKGRIRLTIGHIGAIGALRNDVKILEVSHKALQAEGILDDDLDVEIISQTGCGESYEGVAVAADMYHLQKVKAFIGPYCNAEMDAVARMAAFWNIPIIGYMAASNNLADKNAYPTLARISLRTTNSIAEATCAMLRHYGWNKVAIITNTGILAYDRVLSFEEVFHQRGINVVKKIMFDEFADSKAMIASGLLNDIKNSARIVVCLFSNTRESSREFLTAANTQGMNVNEYGYVFPWLQDGGKDASPWTGADGSMLQKVKDQYANAIIIDDVNSFDNTIVGPFIERIKDVGLTEADVDIANIYGYLYLFDALKLYAIAARKVLNETGKAENLLNGRMMWQNMRKLKFVGMVGASGIASGQVSMDDRAERAPLYRGFFVSPNSDSVLPMVHMEPTMLDNCDGIANKSGCYEIVVTDIMRDFWPSVDRKMPKDEPDCGYRNERCDYTLIIIGAALILLFIVAAVSAFFAQKILEKRALDKLPFRIYRDDLQFIDEEQLKSMLSLGSTRTKMSNMNYGSRNHAIVGTNTHAIYHKYVQRRPIVFNRADKTLIQLMKAAVHDNINPFLGMVWNEREEMLLVWKFCSRGTLQDIIYNESIQLDTKFHGAFIRDILAGLEYLHASQIGYHGSLTPWSCLIDRNWMIKLTDYGIADPLERWEKSQSISRDGLTSDDDKSQATQATSILYESPEMLKNREKNRVRRVDQDWMRQTQTRRQLGDVYAFGLVMYEIIFRALPFPEGTNQSELVEWLRDGSKVVKPTIPQNKVLNMDLSALIQDCWNTTPEMRPSLRRIKLNVETYLNIKGSLVDQMTRMMEQYANNLEKLVAERTGMLEEANQRADRLLSQLLPAYVANELKLGRPVPPKTFTSSTVLFSDIVGFTEMCQNASPLEVVAVLNGIFDGFDQFIARKDAYKVETIGDAYMVVSGVPEENGHRHINEIASIALDVHKFLSEFIVPHKRDTKVQCRLGFHTGPVAAAVVGLNAPRYCLFGDTVNMASRMESNSEPGKTQISETAKNLLLKEYPDYICEQRGEIPIKGKGLCMTYWLMGTKSEGSGRSGAYLAPSMKSAGTGFTGMLGNSANDYSLNLKNPTGLQR

Protein

Receptor-type guanylate cyclase gcy-8: gcy-8