Protein
Receptor-type guanylate cyclase gcy-14
Organism
Caenorhabditis elegans
Function
Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Regulates chemotaxis responses toward Na(1+) and Li(1+) salt ions and alkaline pH in ASE left (ASEL) sensory neuron. Directly senses environmental alkalinity in ASEL neuron which probably leads to the activation of cGMP-gated cation channel tax2/tax4 (PubMed:23664973, PubMed:19523832).
Similarity
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Sequence
MCLFLLLFPYLASGQFLQTVKVGLLFSKDTASVMRAVGYRTSAAAVLVARDRIRAEHLLDQYDFNFTVKFDECTEGLAGGKTVELINHDNVDVIIGPTCNRAGIAVASLAAYYNVPVFQWGLTTAADIGNVSRYPTTVTLSLDTHSMALGVREVLRRFEWDEFVFIYSNDGDEEKCASMKDDLEKMGIENSDVTLAYMVQIQTVTLDALQKALTEVSKRGRIIIACFANGRGFKKAFVASTVLAGMSTDEYMYMFAEPQSRGFYVDEINGGEHYSWDDTDGNFVTGLTPEQIRDAYGKVLYICDNMGLPTTITPEFANFSSQLISRMTEQPFNCVQDCSNSTYKVPATYAGQLFDAFYAYGVALNRSLTQDPTRANLKNGSFVLSDIGMSFQGVGGGTVTLDDTGTRIVQVYMFALNTSLLPYLAASLVINGSEVEYTPFYKSEADLWSVRPLARPICGFSGLECPPDFVKEYLVYTIIAAVIVVLALLAGCAGLLYTMQMKRKEMERQDLLWQVPFIELQQVQSKSKAEASMHSFASGPSTSTKITVESRSETINFIFYYYQQDILAAMKHDLILQFDAEQKAEFRQMRNFDNDNLNKFIGLCLDGPQLFSLWRFCSRGSLSDVISKSSMQMDSFFMFSLIRDISNGLLFIHNSFLKCHGHLTSRCCLIDDRWQIKISGYGLKSVRTFENPKKEDLLWTPPENLRNENEERLPEGDIYSFGIICSEILTRSSAFDLENRKEKPDVIIYQVKKGGHNPMRPSLDTGETVEINPALLHLIRDCWTERPSERPSIEQVRGHLNGMRDGRKSNLMDHVFNMLETYASTLEEEVSDRTKELVEEKKKSDVLLYRMLPKMVADKLKLGQTVEPETFEQVTIFFSDVVQFTTLAGKCTPLQVVTLLNDLYTIFDGIIEQNDVYKVETIGDGYLCVSGLPHRNGNEHIRHIARMSLGFLSSLEFFRVQHLPSERINLRIGINCGSVVAGVVGLTMPRYCLFGDAVNTASRMESNGKPGKIHVTAEANQMLTQVVGGFRTESRGEVIIKGKGVMETYWLLGEQSRISVSAQAPREKTPEPPRRQSVRSISPIIEKMSEETQKGLYSAYKDFNNGNECVS