Protein
Receptor-type guanylate cyclase gcy-12
Organism
Caenorhabditis elegans
Function
Guanylate cyclase involved in the production of the second messenger cGMP (PubMed:9096403). Acts upstream of cGMP-dependent protein kinase egl-4, most likely by providing cGMP to the kinase in chemosensory neurons to regulate body size (PubMed:21124861, PubMed:26434723).
Similarity
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Sequence
MWPTSVEALRFYHTFAFSPGRRRRLFGLSIVFVIAALCVTSCDADAVPAPSPEAEPSLGAGANPYLLDSLVKRLPKKGDKKEILISYLAAVPTLMGEIDQYLLNLSASNSAQNSSKDRESFSKKLNQIVHCLTTDAYVSVVSGALVAAIVEINQDKDLIPAYQLKYVFGNTCGNDSHSTRLFMEHWQAGARVFIGPEKNCKTEAAMAASQNLPIISYRCNDQDISRDDYHYRTFARTVPPAGEIFKAFMSLMKQYNWRKFSVVYDVKKGQVKNELFETLKRMVETENKFEEHKFEIMNVSKLEFSKMDISSQQDIQSIENAIKSTMQTTRIYLTFDNVRLFRTMLSIMGEMGLTQQDYMLIYVDTNYDWLNVYHSMNNHFLRNTMTYLHHSWDANNSSDRKMLDYARSALSIIPTPVKLNSQRFYNFWKKAGDYMHHFGVQKADNLKGNRIACYLYDAVYLYAKAIHELVEEYGNDDSYDPTADGKAIIDRIVNKKYRSIQGFDMRIDERGNSKGNFSLLSWQKVAPIMNKSDPSYYPLDHALDLTAIFVEAPDKDRLPNLQFKSSRIQWLKGEPPPDEPVCGFHGENCRKKGIFSYLTVVVMILIAVFSLVLTGFTLNYIRSRRFEKELSMIWKIDPYEVRRVVGGVNNESTASLMQSDVMQFAKTKTPWWSKAPVQGTGMRGLASYKGTLVGLKDLMYGRKPKDLTREAKKELRAMRQLAHPNVNNFLGIIVCQYSVTVVREYCSKGSLHDILRNENLKLDHMYVASFVDDLVKGMVYIHDSELKMHGNLKSTNCLITSRWTLQIADFGLRELREGIMYDSSYNIWENFLWTAPEAMTINGSLAISNPPTPKADAYSFGIIFHEIFTREGPYKIYVQRGDVNGEAAPKKDSVECRALVEKTVRRVYSDPYFRPDTSDLEVQNYVKEVMAACWHHDPYQRPEFKTIKNKLKPLFHQIYKQNIMDHMVLMMEKYQTQLEDLVDERTIELKDEQRRSQHLLQRMLPSSVAEQLLAGQDVIPEAFPPVTIYFSDIVGFTTISGESTPMEVVTFLNKLYTLFDSIIRRYDVYKVETIGDAYMVVSGVPQYKTMEYHAEQIAMMAIHILSAVRSFSIPHRSCEPLMIRIGMHTGPCVAGVVGKTMPRYTLFGDTVNTASRMESNGEALRIHCSSSTQKVLTSIDQGFLLEERGSLAIKGKGQMTTYWLNGRAGYEFTETIEDKMVVPDIFPRPNLKNRGSSWGVNRESSLSLATEKSSQIMKRQSAAMNRNNQDVIYYNQPLNSGGFTSRGTSNREMPKLYEEDRESLLNQSASLLGSRTSGRKKSTASKYNGFSASRMFSSTISNASSSRPSRPSTFDHDTLALRKRSTSLPDGEKLNLEFIETTNLANNSVPAIPNNISSLEPVFRKASIIDGYSSQSESPSQSQYPSYRDLTTGPHQRKRGIATVFPVRKRSLSCGDAVPLKINENGASGSITTAVSPRSSCRALDPTMKLAARASSPDEIIFQEDDEDALIDNDSLLTSNGNSKSEDVLRTCPQPRRKNKHSFLRDPSPLAKRFRDASPFGKKKPFWNSNKSNEHTSSPADSISRLFRRFRGGSVNEYADLNHYCDDEDESGRANGYEMQEMGKMTGRQREQRNGSRTNRSVSCSPDECGTLTDSSDPHLTIPSSSIGDSSASTSLSCS