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gck

Gene
GCK
Protein
Glucokinase
Organism
Homo sapiens
Length
465 amino acids
Function
Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage.
Similarity
Belongs to the hexokinase family.
Mass
52.191 kDa
Sequence
MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
Protein
Glucokinase: GCK

Gene
Gck
Protein
Glucokinase
Organism
Mus musculus
Length
465 amino acids
Function
Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage.
Similarity
Belongs to the hexokinase family.
Mass
52.089 kDa
Sequence
MLDDRARMEATKKEKVEQILAEFQLQEEDLKKVMSRMQKEMDRGLKLETHQEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGNSGELDEFLLEYDRMVDESSVNPGQQLYEKIIGGKYMGELVRLVLLKLVEENLLFHGEASEQLRTRGAFETRFVSQVESDSGDRRQILNILSTLGLRPSVADCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPNCEITFIESEEGSGRGAALVSAVACKKACMLGQ
Protein
Glucokinase: Gck

Gene
Gck
Protein
Glucokinase
Organism
Rattus norvegicus
Length
465 amino acids
Function
Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage.
Similarity
Belongs to the hexokinase family.
Mass
52.116 kDa
Sequence
MLDDRARMEATKKEKVEQILAEFQLQEEDLKKVMSRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDLDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRMVDESSANPGQQLYEKIIGGKYMGELVRLVLLKLVDENLLFHGEASEQLRTRGAFETRFVSQVESDSGDRKQIHNILSTLGLRPSVTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPNCEITFIESEEGSGRGAALVSAVACKKACMLAQ
Protein
Glucokinase: Gck

Gene
gck
Protein
Glycerate 2-kinase
Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Length
440 amino acids
Function
Catalyzes the ATP-dependent phosphorylation of D-glycerate to 2-phosphoglycerate. It can also utilize GTP, CTP, UTP, ADP or pyrophosphate as phosphate donor.
Similarity
Belongs to the glycerate kinase type-1 family.
Mass
47.375 kDa
Sequence
MIAMDIREIGLRLVGEAIKAADPYRAVLNAVKVSDDKIIVQGKEFEIKGKVYVIALGKAACEMARAIEDILDVEDGVAVTKYGYGKELKRIKVIEAGHPIPDEKSILGAKEALSILNRARENDIVFILISGGGSALFELPEEGISLEDLKLTTDLLLKSGAKIHEINTVRKHISKVKGGKLAKMIKGTGIVLIISDVVGDNLEAIASGPTVKDPTTFEDAKRILELYDIWEKVPESVRLHIERGLRGEVEETLKEDLPNVHNFLIASNSISCEAIAREAQRLGFKAYIMTTTLEGEAKDAGLFIGSIVQEIAERGRPFEPPVVLVFGGETTVTIEGKGGKGGPNQEIALSATRKISDLEALIVAFDTDGTDGPTDAAGGIVDGTTYKKLREKGIDVEKVLKEHNSYEALKKVGGLLFTGPTGTNVNSIVIAIVTSKRGRT
Protein
Glycerate 2-kinase: gck

Gene
gck
Protein
Glycerate 2-kinase
Organism
Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)
Length
415 amino acids
Function
Catalyzes the ATP-dependent phosphorylation of D-glycerate to 2-phosphoglycerate. It can also partially utilize GTP, CTP or UTP as phosphate donor.
Similarity
Belongs to the glycerate kinase type-1 family.
Mass
46.644 kDa
Sequence
MIENYNDIAITDTRRKILNIIDKTLIAMDPENAIKNFIEKNNIKFDSKRIFLIGFGKAAFKMYSGIRPFILKDLVYASIIVPDDEKTNDYNELRILRGTHPFTGDLSVSSSISMLSGLKNLNENDLVIVLISGGGSSLFEIPEDGINIDDIKNISKTMMDKGCDIYELNMVRSMLSKVKGGKLATMLYPARVISFIISDVKNDDLSIIASGPLTRIDYRIEDLMETIKKYLGNDERIKMYRNIDDIYFNNVKQYIILKNRDFLDYIYSNINDDAVNLGSNFSGNVEDLSLILHNILKNIYSSKRKPFYFMLGGETTVDVKGHGSGGRNQELVLRFMKNSSNSEVYTIASFGTDGIDGVSPAAGGIVDSDHEIDNINEYLNRNDSYNLLIKNHGAIITGRTGNNVSDIIIGLYYNK
Protein
Glycerate 2-kinase: gck

Gene
gck
Protein
Glycerate 2-kinase
Organism
Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Length
399 amino acids
Function
Catalyzes the ATP-dependent phosphorylation of D-glycerate to 2-phosphoglycerate. It can also utilize GTP, CTP, UTP, ADP, AMP or pyrophosphate as phosphate donor.
Similarity
Belongs to the glycerate kinase type-1 family.
Mass
44.01 kDa
Sequence
MDKIIEKILTFSDPYIALDERVVIKKNEIIVDGNHFPYTKPAIIAVGKASYKMAKFFIDKLKDVKGLVILPKGSYISLPKVEVIESTHPDISELSFKAGTEVIKFLKNEDYDLLIFLLSGGASALMEYSNVPYEILRDINEKLVKSGLSVNEINIVRKHLSLIKGGKLTEFSKAPILTLIVSDVPGGDLSAVGSGPTLPDSSTVDDAKLILNKVGLGEYSKYLIETKKEVHNSFNFLILDINIVLRKLRDIVQNPIILSSEIRGDAYSFGQNLAGIVNTSFSNLGLKPPYTLLAGGEPDVKIEGKAGKGGRNGEVCLGFLKWVKRNSNHRFKLYAIATDGIDGNSEYAGCIVDENTIVDNIEYYIYSHSSYEALEKVGRVIKTGYTFTNVNNVYVLEVT
Protein
Glycerate 2-kinase: gck