gcg1

Gene

gcg1

Protein

Glucagon-1

Organism

Xenopus laevis

Length

266 amino acids

Function

Promotes hydrolysis of glycogen and lipids, and raises the blood sugar level.

Similarity

Belongs to the glucagon family.

Mass

30.951 kDa

Sequence

MKSTCYMIGILLMILQNTYQSPVPETDANSRSVKAARNEAVDDSEQLKEVKRHSQGTFTSDYSKYLDSRRAQDFVQWLMNTKRSGELSRRNADYERHAEGTFTSDVTQQLDEKAAKEFIDWLINGGPSKEIISRRNAEFERHAEGTYTNDVTEYLEEKAAKEFIEWLIKGKPKKIRYSRHAEGTFTNDMTNYLEEKAAKEFVGWLIKGRPKRNFSEVHSVEEMDRRHADGSFTNDINKVLDIIAAQEFLDWVINTQETERDLLEEQ

Protein

Glucagon-1: gcg1

Gene

GCG1

Protein

Glutathione-specific gamma-glutamylcyclotransferase

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c)

Length

232 amino acids

Function

Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. Allows utilization of gluthathione through subsequent cleavage of the Cys-Gly dipeptide by Cys-Gly metallodipeptidase DUG1.

Similarity

Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.

Mass

26.294 kDa

Sequence

MTNDNSGIWVLGYGSLIYKPPSHYTHRIPAIIHGFARRFWQSSTDHRGTPANPGRVATLIPYEDIIRQTAFLKNVNLYSESAPIQDPDDLVTIGVVYYIPPEHAQEVREYLNVREQNGYTLHEVEVHLETNREHEAELGEALEQLPRHNKSGKRVLLTSVYIGTIDNEAFVGPETVDETAKVIAVSHGPSGSNYEYLAKLEQALAQMPIMKERGRITDHYLTALLETVNKYR

Protein

Glutathione-specific gamma-glutamylcyclotransferase: GCG1

Gene

gcg1

Protein

Glucagon-1

Organism

Oncorhynchus mykiss

Length

178 amino acids

Function

Promotes hydrolysis of glycogen and lipids, and raises the blood sugar level.

Similarity

Belongs to the glucagon family.

Mass

20.034 kDa

Sequence

MFGIHSLAGVLLLVIVQRQLASPLQEAEDNSSLETTDPLLEDLMGVSNVKRHSEGTFSNDYSKYQEERMAQDFVQWLMNSKRSGAPSKRHADGTYTSDVSTYLQDQAAKDFVSWLKSGRARRESAEESRNGPMSRRHVDGSFTSDVNKVLDSLAAKEYLLWVMTSKTSGKSNKRQEDH

Protein

Glucagon-1: gcg1

Gene

gcg1

Protein

Glucagon-1

Organism

Petromyzon marinus

Length

160 amino acids

Function

Promotes hydrolysis of glycogen and lipids, and raises the blood sugar level.

Similarity

Belongs to the glucagon family.

Mass

18.042 kDa

Sequence

MSDPGFLAAPVLLLLLVSLASASLEQAASRDDDSAERPLSKRHSEGTFTSDYSKYLENKQAKDFVRWLMNAKRGGSELQRRHADGTFTNDMTSYLDAKAARDFVSWLARSDKSRRDGGDHLAENSEDKRHAEDVNALLDRTMAKTFIEWLEKQNSNDQTD

Protein

Glucagon-1: gcg1

Gene

gcg1

Protein

Glucagon-1

Organism

Lophius americanus

Length

124 amino acids

Function

Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis.

Similarity

Belongs to the glucagon family.

Mass

14.165 kDa

Sequence

MKRIHSLAGILLVLGLIQSSCRVLMQEADPSSSLEADSTLKDEPRELSNMKRHSEGTFSNDYSKYLEDRKAQEFVRWLMNNKRSGVAEKRHADGTFTSDVSSYLKDQAIKDFVDRLKAGQVRRE

Protein

Glucagon-1: gcg1

Gene

gcg1

Protein

Glucagon-1

Organism

Oreochromis niloticus

Length

36 amino acids

Function

Promotes hydrolysis of glycogen and lipids, and raises the blood sugar level.

Similarity

Belongs to the glucagon family.

Mass

4.252 kDa

Sequence

HSEGTFSNDYSKYLEDRKAQDFVRWLMNNKRSGAAE