GCD10

tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6

478 amino acids

Substrate-binding subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA (PubMed:10779558, PubMed:9851972). Also required for repression of GCN4 mRNA translation by the upstream open reading frames (uORFs) under conditions of amino acid sufficiency (PubMed:7542616).

Belongs to the TRM6/GCD10 family.

54.389 kDa

MNALTTIDFNQHVIVRLPSKNYKIVELKPNTSVSLGKFGAFEVNDIIGYPFGLTFEIYYDGEEVSSDENRDSKPKNKIPIGKVRLLSQEIKDVNNDKDDGQSEPPLSIKEKSVSLELSSIDSSATNQNLVNMGSKAQELTVEEIEKMKQESLSSKEIIDKIIKSHKSFHNKTVYSQEKYVNRKKQKFAKYFTVEYLSSSNLLQFLIDKGDIQRVLDMSQESMGMLLNLANIQSEGNYLCMDETGGLLVYFLLERMFGGDNESKSKGKVIVIHENEHANLDLLKFANYSEKFIKEHVHTISLLDFFEPPTLQEIQSRFTPLPKEEARALKGGKKNSYYRKLRWYNTQWQILELTGEFLYDGLVMATTLHLPTLVPKLAEKIHGSRPIVCYGQFKETLLELAHTLYSDLRFLAPSILETRCRPYQSIRGKLHPLMTMKGGGGYLMWCHRVIPAPEPVSENATAADSSEKLAEHGAKKQKI

gcd10

tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit trm6

462 amino acids

Substrate-binding subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.

Belongs to the TRM6/GCD10 family.

53.201 kDa

MLRHASTISENSSVFIKLPSDNVRFVTLKPNNTIHLGKFGSFLADDLFGKHFDETFEIYQPKKIRVLKTREVQYIEEEKKTNQELNDCRGNQLMTQEEIDELRANIKAGGLRAEEAIKQLTNSSKTFEQKTLFAQEKYVTRKGEKYLQRFQVLRPCVEVVANYMIEHDPYKILDLTAECISLMLTLGNVKPGGRYLVVDETGCMFLGSLIDRVAGDCKITLVHPNEQPNSSCLEYWGQDFKEDSLVQKGILKTLNWYQVTNPTETLSEYSVEDIPESELNEMKLRHRKRYETKKATFNRLKNTIDDFESGNYDALFILSIHTPMSVLQHLLPKLGISRPFMVYSTYQQVLVETYHQLSKWDNLFVEKTAQSTENDEKVDQGDVAIDTQKEKVIMLDIHEIRTRPYQVLPERTHPFMTVRGDMGFVLSGIKVLTSDSNLAAGRFPKRKGQKETSSVKKAKLEN