Protein
Guanylyl cyclase, membrane
Organism
Dictyostelium discoideum
Function
Synthesizes cyclic GMP (cGMP) from GTP, after activation by heterotrimeric or monomeric G proteins. Involved in chemotaxis.
Similarity
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Sequence
MMFGNLPDVRKPKEGYKKYLEYFDLRFPRIQEEKHFQSYYYYTYLKQIRISIIFLTSVLFIGTMTAYISPLDISYLPYYDSKNIYYFNYVQPNVTTTSSSTTTTSSTTNSIDSTVENNNFTEADGHLTNYYFPYLANKARDTFILRMITIGLLLFYFIFTFTAKFKRLWKLFTTITLFLVSCIVLIFESDIRTIPGRMVLLFIIIAISSGMTFLPSMLASGGLCLFFFFYFMFYSQIAGKQMVLLSLVLLISWIILMIISRFKEQLFRDKFRTLENLKIQTIRSEKIINQMLPTVVVQRLRLQSSKDQSLETTLENDKELSIKKDEESNLTGKKQSKVVVSPPPPPTAAAPQQQDNEISTPQNSRKIVDPQSPSSLMPGQYSVTDLIVDSYDPVTVLFCEIVNFNALVEKMSSTQVINLLNEVYNSFDRLTDVYGVTKVEHIGNVYMVVGGCPELCPDHAQRVAHMSLGMLSVIRRFGIVQVRIGMHTGPVVGGIIGKKKLSWHLFGDTINTSSRMASHSSIGRIQVSHPVQQLLRPYFLFEDRGKIQVKGKGLMRTFYLVKTKQLDKRYTSIFSSLHREKPYIPPVDISEVSFENQNNTIGKGDDIASGSATGPTHPNIPNSMLSAIPSRVSIEMNPLGGSGSIQKRERKGSIFANVMPPKVLNFLQTGSLTSPQQQPLPQQSNSEETISNSPRLSSTPQSTSTLQHSSSTGALGSLINNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNLPVSLISPISQNTTPTGSLSLPVTEKKKQTVQFGSISRSSSISKGTVGRSPSPALFDGGIEMDDNGGGAGDDFNTMEPNLDLGKGIHGSNVISTNNSKLNKLEKDLTKHYTLDKFKLSFISRGNLVEKEYRNEYILKNWNRILASMLMIVALFGLSGLVDYFFLKLSSISSIVKVEPMPSSSSSSLSSSSSNSMTSSEEKFITLHTIRSEENLIYDIITGVRYGFVFFCLIVIYVVSKFKTFSIRKWIQEVVMVFFIVLAAVLIVLTSVPPLNKIPLDSVILSIEIMFITICYNFSGIKFWYSNIVCAFCIIFIEISKTWKQAYHSRDIYLSHNYYLITAVLINIITSYFEELFNRLNWVHGRLLDKDQRETESLVAEILPADIVKSMKSGRQLIVDEFKNVTIFLSDIVGFTEMAARMSPRQLVETLNQIYSTFDEIAQEFGVLKIATIGDAYFCVSGCPDKDQTDHAFRVANMAIKMLESIKSIRTVDNIPIRMRIGIHTGPVIAGVVGIKMIHYQLWGESVQITQQMESTSRADMIHVSEDTFNILKSKYLFEERPDGIIKKRKIKTYFLLRALTENDPQPEVKTRSVSVSKSNFGGSLQYNQITPTLNLPVSQLIIKDQNEIKNQNDHDNDDENGNENGNESSSSNINEEEEDDDNSNNNNNNEDDESSYEDDQEMNQYLNNSENNKNNNNNSNQINEEDGNWAKNYDGSSESS