GAREM1

GRB2-associated and regulator of MAPK protein 1

876 amino acids

Isoform 1: Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation.

Belongs to the GAREM family.

97.186 kDa

MDPAPSLGCSLKDVKWSSVAVPLDLLVSTYRLPQIARLDNGECVEGLRENDYLLIHSCRQWTTITAHSLEEGHYVIGPKIEIPVHYAGQFKLLEQDRDIKEPVQYFNSVEEVAKAFPERVYVMEDITFNVKVASGECNEDTEVYNITLCTGDELTLMGQAEILYAKTFKEKSRLNTIFKKIGKLNSISKLGKGKMPCLICMNHRTNESISLPFQCKGRFSTRSPLELQMQEGEHTIRNIVEKTRLPVNVTVPSPPPRNPYDLHFIREGHRYKFVNIQTKTVVVCCVLRNNKILPMHFPLHLTVPKFSLPEHLVKGESWPETLVHHWLGICQEQFDIDEYSRAVRDVKTDWNEECKSPKKGRCSGHNHVPNSLSYARDELTQSFHRLSVCVYGNNLHGNSEVNLHGCRDLGGDWAPFPHDILPYQDSGDSGSDYLFPEASEESAGIPGKSELPYEELWLEEGKPSHQPLTRSLSEKNRCDQFRGSVRSKCATSPLPIPGTLGAAVKSSDTALPPPPVPPKSEAVREECRLLNAPPVPPRSAKPLSTSPSIPPRTVKPARQQTRSPSPTLSYYSSGLHNISVTKTDTNPSESTPVSCYPCNRVKTDSVDLKSPFGSPSAEAVSSRLSWPNHYSGASESQTRSDFLLDPSRSYSYPRQKTPGTPKRNCPAPFDFDGCELLASPTSPVTAEFSSSVSGCPKSASYSLESTDVKSLAAGVTKQSTSCPALPPRAPKLVEEKVASETSPLPLKIDGAEEDPKSGSPDLSEDQYFVKKGMQDIFSASYPFSSPLHLQLAPRSCGDGSPWQPPADLSGLSIEEVSKSLRFIGLSEDVISFFVTEKIDGNLLVQLTEEILSEDFKLSKLQVKKIMQFINGWRPKI

Garem1

GRB2-associated and regulator of MAPK protein

876 amino acids

Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation (By similarity).

Belongs to the GAREM family.

97.25 kDa

MDPAPSLGCSLKDVKWSPVAMPLDLLVSTYRLPQIARLDSGECVEGLRENDFLLIHSCRQWTTITAHSLEEGHYVIGPKIEIPVHYAGQFKLLEQDRDIKEPVQYFNSVEEVAKAFPERVYVMEEITFNVKVASGECNEDTEVYNITLCTGDELTLMGQAEILYAKTFKEKSRLNTIFKKIGKLNSISKLGKGKMPCLICMNHRTNESISLPFQCKGRFSTRSPLELQMQEGEHTIRNIVEKTRLPVNVTVPSPPPRNPYDLHFIREGHRYKFVNIQTKTVVVCCVLRNNKILPMHFPLHLTVPKFSLPEHQVKGDMWPETLVHHWLGICQEQFDIDEYSRAVRDVKTDWNEDCKSPKKGRCSGHNHLPNSLSYARDELTQSFHRLSVCVYGNNLHGNSEVNLHGCRDLGGEWAPFPHDILPYQDSGDSGSDYLFPEANEESAGIPGKTEVPYEELWLEEGKPSRQPLTRSLSEKSRCDTLRGSTRSTCAPSSPPTPATLGATIKSSEIALPPPPVPPKSEAVREECRLLNAPPVPPRSAKPLSTSPSIPPRTVKPVRPQTRSPSPTLSYYSSGLHNIITQSDTSPPNSAPVSCYPCTRVKSDSVDPKSPFGSPSAEALSSRLSWPNHYSGASENQTRSDFLLDPSRSYSYPRQKTPGTPKRTCPAPFDFEGCELLGSPPSTTSAEFSSSGVPSCPKSASYCLENSEDNSFAAGMTKQSVSCPALPPRAPKPVEQKATPETSPLPLKIDGAEEDPTAGSLDLSEDQYFVRKGMQDIFSVSYPFSSPLHLQLAPRSCGDGSPWQPPADLSGLSIEEVSKSLRFIGLSEDVIAFFVTEKIDGNLLVQLTEEILSEDFKLSKLQVKKILQFINGWRPKI

garem1

GRB2-associated and regulator of MAPK protein

876 amino acids

Adapter protein that may provide a link between cell surface epidermal growth factor receptor and the MAPK/ERK signaling pathway. May promote cell proliferation (By similarity).

Belongs to the GAREM family.

97.431 kDa

MELPVPSLKDVKWSSASFPLDLLVSSYRLPQLVRVDCAGENVEGLRENDCLLIHSCRQWTTITAHSLEEGHYVIGPKIEIPVHYGGQFKLLEQDRDIKEPVQYFNSVEEVAKAFPERVYVMEEITFNVKVASGECNEDTEVYNITLCTGDELTLMGQAEILYAKTSKEKSRLNTIFKKIGKLNSISKLGKGKMPCLICMNHRTNESISLPFQCKGRFSTRSPLEIQMQEGEHTIRNIVEKTRLPVNVTVPSPPPRNSYDLHFIREGHRYKFVNIQTKTVVVCFALHTNKIVPMHFPLHLSVPKFSLPENLIKGEVWQDSVVQHWYNICQEQFDIEEYSRAVRDVKADWSEECKSPKKNWSAGHSHIPNSLSYARDELTQSFHRLSVCVYGNNLHGNSEVNLHGCRDLCGDWAAFPQDSPQYQDSCDSGSDYLFSETSEELTSLPAKPELPYEELWLEQGSVKRSGQPLTRSQSEKNKCDSFRGSLPSRCGTSSLPSPGALLTTKSLDVSLPPPPVPPKSEAVKEECRLLNAPPVPPRSSKPSSPTPSVPPAAENIVRQQTRSPSPTLSYYSSGLHSIGITESETTSSSDNSQVSCYPCNWMKNESSDLESNLTCGSASSEALPSRLSWPNRYCGGAEGLNVNDLPMDQCRSYYSYPRQKTPGTPKKNSPATFDFGGCGSFTGCNQGEFSDTVPGCPKSASYSLESATDRMLGDNSTKQSLSCPALPPRAPKPSEGNALSEPLSLPMKIDGAEEEIQTCSPDFLEEHYLAKKGVQDIFSISYPFSSPLHMQLAPRSCGDGSPWQPPTDLSGLSVEEVSKSLRFIGLSEDVVSFFVSEKIDGNLLVQLTEEILSEDFKLSKLQVKKLLQFINGWRPKM

garem1

GRB2-associated and regulator of MAPK protein 1

867 amino acids

Adapter protein that may provide a link between cell surface epidermal growth factor receptor and the MAPK/ERK signaling pathway. May promote cell proliferation (By similarity).

Belongs to the GAREM family.

95.793 kDa

MDLGSMLYNSFNNITWSTTTLPLDRLISSYRLPQIVKLDSGESVEGLRENDYLLIHSCRQWTTITAHSLEEGHYVIGPKIEIPVHYEGQFKLLEQDRDIKEPVQYYNSVEEVAKAFPERVYVMEEISFNFKMASGESNEDTEVYNITLSTGDELTLMGQAELLYAKSSREKSRFNTIFKRIGKLNSISKLGRGKMPCLICMNHRTNESISLPFQCRGRFSTCSQLELQMQEGEHTIRTIVEKTRLPVNVMVPSSPPRNPHDLHLIREGHRYKLVNIQTKTVVVCCALRSNKILPVHFPLHVSTALPRLLVPEGLLQGESWFETVVHRWFTYCQEQFDIDDYSRAVRDVRVDWIEDGKSPKKSSAGGTGSGSAICNSSGSGSNGCPSHLHLPSSLSSARDELTQSFHRLSVCVYGNNLHGNSEVNLQGCVSLCGDCAPAEPPDADYLFPELQENSSGSLKSDVPYEELWLDHVKNAGPVLDHNEGVRGNSLSSGCTTALPYPKAGPTSALLSADVNLPPPPVPPKSEAVKEECRLLDAPPIPPRSSKQAGSSSATVPYPSAKPRQKDTRSPSPTLSYYSSGLHSIGGEGESQIESDDQNHACYPCSWIRPDASESSKPLPCLNPSVNASFSRLSWPNDFCGADSYKGEDFQSLHCRSYSSYPRKRTPGTPKACPSGLLDFDKRANFEGKAVSSKVQQVTQSAQFCTKSTSYNMDMCRDKPTDECITKQSQSCPILPPRTPKCTDAKKDAEAATTDTADADAVELESKSCSPDGPHPGTTDVFSVSHPVATGLSWQPPSNLSGISIEEISKSLRFIGLSEDVVSLFVQEKIDGNLLLQLTEEILSEDFKLSKLQVKKLMQFINGWRPKM