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gap1

Gene
gap1
Protein
GTPase-activating protein
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
766 amino acids
Function
Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase activity of Ras1.
Mass
87.54 kDa
Sequence
MTKRHSGTLSSSVLPQTNRLSLLRNRESTSVLYTIDLDMESDVEDAFFHLDRELHDLKQQISSQSKQNFVLERDVRYLDSKIALLIQNRMAQEEQHEFAKRLNDNYNAVKGSFPDDRKLQLYGALFFLLQSEPAYIASLVRRVKLFNMDALLQIVMFNIYGNQYESREEHLLLSLFQMVLTTEFEATSDVLSLLRANTPVSRMLTTYTRRGPGQAYLRSILYQCINDVAIHPDLQLDIHPLSVYRYLVNTGQLSPSEDDNLLTNEEVSEFPAVKNAIQERSAQLLLLTKRFLDAVLNSIDEIPYGIRWVCKLIRNLTNRLFPSISDSTICSLIGGFFFLRFVNPAIISPQTSMLLDSCPSDNVRKTLATIAKIIQSVANGTSSTKTHLDVSFQPMLKEYEEKVHNLLRKLGNVGDFFEALELDQYIALSKKSLALEMTVNEIYLTHEIILENLDNLYDPDSHVHLILQELGEPCKSVPQEDNCLVTLPLYNRWDSSIPDLKQNLKVTREDILYVDAKTLFIQLLRLLPSGHPATRVPLDLPLIADSVSSLKSMSLMKKGIRAIELLDELSTLRLVDKENRYEPLTSEVEKEFIDLDALYERIRAERDALQDVHRAICDHNEYLQTQLQIYGSYLNNARSQIKPSHSDSKGFSRGVGVVGIKPKNIKSSNTVKLSSQQLKKESVLLNCTIPEFNVSNTYFTFSSPSTDNFVIAVYQRGHSKVLVEVCICLDDVLQRRYASNPVVDLGFLTFEANKLYHLFEQLFLRK

Gene
GAP1
Protein
General amino-acid permease GAP1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
602 amino acids
Function
General amino-acid permease involved in the uptake of all the naturally occurring L-amino-acids, related compounds such as ornithine and citrulline, some D-amino acids, toxic amino acid analogs such as azetidine-2-carboxylate, and the polyamines putrescine and spermidine (PubMed:5474888, PubMed:10467005, PubMed:10373490, PubMed:10953083, PubMed:14968425, PubMed:15707981). Senses its transport substrates to set an appropriate level of transporter activity at the cell surface (PubMed:21471002). Required for FLO11 expression and invasive growth (PubMed:22844449).
Similarity
Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
Mass
65.656 kDa
Sequence
MSNTSSYEKNNPDNLKHNGITIDSEFLTQEPITIPSNGSAVSIDETGSGSKWQDFKDSFKRVKPIEVDPNLSEAEKVAIITAQTPLKHHLKNRHLQMIAIGGAIGTGLLVGSGTALRTGGPASLLIGWGSTGTMIYAMVMALGELAVIFPISGGFTTYATRFIDESFGYANNFNYMLQWLVVLPLEIVSASITVNFWGTDPKYRDGFVALFWLAIVIINMFGVKGYGEAEFVFSFIKVITVVGFIILGIILNCGGGPTGGYIGGKYWHDPGAFAGDTPGAKFKGVCSVFVTAAFSFAGSELVGLAASESVEPRKSVPKAAKQVFWRITLFYILSLLMIGLLVPYNDKSLIGASSVDAAASPFVIAIKTHGIKGLPSVVNVVILIAVLSVGNSAIYACSRTMVALAEQRFLPEIFSYVDRKGRPLVGIAVTSAFGLIAFVAASKKEGEVFNWLLALSGLSSLFTWGGICICHIRFRKALAAQGRGLDELSFKSPTGVWGSYWGLFMVIIMFIAQFYVAVFPVGDSPSAEGFFEAYLSFPLVMVMYIGHKIYKRNWKLFIPAEKMDIDTGRREVDLDLLKQEIAEEKAIMATKPRWYRIWNFWC

Gene
GAP1
Protein
Amino-acid permease GAP1
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876)
Length
582 amino acids
Function
Amino-acid permease that coordinates external nitrogen source response and morphogenesis (PubMed:12949183, PubMed:21764911, PubMed:28028545). Is capable of transporting several structurally unrelated amino acids such as leucine and phenylalanine, though with a lower capacity than the GAP2 and GAP6 permeases (PubMed:21764911). Has citrulline import activity (PubMed:12949183). GAP1 is also able to transport thialysine, and thus probably also lysine (PubMed:21764911). Functions as a sensor via detection of some amino acids including methionine, leading to a rapid activation of trehalase, a downstream target of PKA (PubMed:21764911).
Similarity
Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
Mass
63.951 kDa
Sequence
MLHKKETNDTFVQLNRSPSTGEQKSSGIWSSIKDSFKPALPQDKLTGVDDIPDRELTDIERININAANSNLQRKLKTRHLQMIAIGSSIGTGLFVGTGGALSTGGPAAIVLAWAISAISVFMTMQGLGELAVAFPVSGGFNLYASKFLEPGIGFAVGWNYFLQFFVLLPLELVAGAITIKYWNASINSDVFVIIFWFVVLVITMLGVRWYGEAELVFCTIKVIAVIGFIILGIVLICGGGPNHEFIGGKYWREPGPFANSFKGFASSLITAAFSFGGTEMIALTASESSNVRHALPKAIKQVFWRIVIFYLGSIIMIATLVPYNDKRLLGSSSVDVTASPFTIAIVNGGIKGLPSVINAVILISVLSVGNASVYATSRTLNSLAEQGMAPKWTGYIDRAGRPLFAILITNVFGLFALIAADNEKQVVAFNWLLALSGLSSIFTWMSINLSHIRFRRAMKVQNRSLTELPFVAQSGVWGSYFGLTLNILYLIAQFYIGLFPVGGKPNAYDFFLAYLGVPVILASWIGYKIWKRDWTLFIRAKDIDLDTGRINVDLDLLQQEIAEEKAQLAEKPFYIRIYRFWC

Gene
gap1
Protein
Glyceraldehyde-3-phosphate dehydrogenase 1
Organism
Anabaena variabilis (strain ATCC 29413 / PCC 7937)
Length
343 amino acids
Function
Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG.
Similarity
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
Mass
36.666 kDa
Sequence
MAKLKVGINGFGRIGRLVLRAGINNPNIEFVGINDLVPPDNLAYLLKYDSTHGKLRSQVEAKDDGIVIDGHFIPCVSVRNPAELPWGKLGADYVVESTGLFTDSEGASKHLQAGAKRVIISAPTKDPDRVRTLLVGVNHDLFDPSKDVIVSNASCTTNCLAPIAKVINDNFGLTEGLMTTVHAMTATQPTVDGPSKKDWRGGRGAAQNIIPSSTGAAKAVALVLPELKGKLTGMAFRVPTPDVSVVDLTFKTAKATSYKEICAAMKQASEGSLAGILGYTDEEVVSTDFQGDTHSSIFDAGAGIELNSNFFKVVAWYDNEWGYSNRVVDLMLSMIQKEQLAAV

Gene
gap1
Protein
Glyceraldehyde-3-phosphate dehydrogenase 1
Organism
Anabaena variabilis (strain ATCC 29413 / PCC 7937)
Length
343 amino acids
Function
Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG.
Similarity
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
Mass
36.666 kDa
Sequence
MAKLKVGINGFGRIGRLVLRAGINNPNIEFVGINDLVPPDNLAYLLKYDSTHGKLRSQVEAKDDGIVIDGHFIPCVSVRNPAELPWGKLGADYVVESTGLFTDSEGASKHLQAGAKRVIISAPTKDPDRVRTLLVGVNHDLFDPSKDVIVSNASCTTNCLAPIAKVINDNFGLTEGLMTTVHAMTATQPTVDGPSKKDWRGGRGAAQNIIPSSTGAAKAVALVLPELKGKLTGMAFRVPTPDVSVVDLTFKTAKATSYKEICAAMKQASEGSLAGILGYTDEEVVSTDFQGDTHSSIFDAGAGIELNSNFFKVVAWYDNEWGYSNRVVDLMLSMIQKEQLAAV

Gene
gap1
Protein
Glyceraldehyde-3-phosphate dehydrogenase 1
Organism
Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)
Length
343 amino acids
Function
Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG.
Similarity
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
Mass
36.752 kDa
Sequence
MAKLKVGINGFGRIGRLVLRAGINNPNIEFVGINDLVPPDNLAYLLKYDSTHGRLRSQVETKDDGIVIDGHFIPCVSVRNPAELPWGKLGADYVVESTGLFTDSEGASKHLQAGARRVIISAPTKDPDRVRTLLVGVNHDLFDPSKDLIVSNASCTTNCLAPIAKVINDNFGLTEGLMTTVHAMTATQPTVDGPSKKDWRGGRGAAQNIIPSSTGAAKAVALVLPELKGKLTGMAFRVPTPDVSVVDLTFKTAKATSYKEICAAMKQASEGSLAGILGYTDEEVVSTDFQGDTHSSIFDAGAGIELNSNFFKVVAWYDNEWGYSNRVVDLMLSMVQKEQLAAV

Gene
gap1
Protein
Glyceraldehyde-3-phosphate dehydrogenase 1
Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Length
339 amino acids
Function
Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG.
Similarity
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
Mass
36.146 kDa
Sequence
MLKIGINGFGRIGRLVARIAMANPQVTLVGINDLVPASNLAYLFKYDSTHGSYGGTVVAKEEGIVIDDQFIPCFSQRNPAQLPWGDLGADYVVESTGLFTTYATAENHLKAGAKRVIISAPSKDPEKIPTFVVGVNHLNYNADTDKIVSNASCTTNCLAPIAKILDDNFGIVEGLMTTVHAMTATQPTVDGPSKKDFRGGRGAAQNIIPSSTGAAKAAALVLPQLKGKLTGMAFRVPTPNVSVVDLTFKTEKATSYEEICAAMKTAAEGELKGILGYTADDVVSMDFRTDPRSSIFDAGAGIGLNSNFFKVVSWYDNEWGYSCRVIDLMLTMASKDGLV

Gene
gap1
Protein
Glyceraldehyde-3-phosphate dehydrogenase 1
Organism
Methanosarcina barkeri (strain Fusaro / DSM 804)
Length
338 amino acids
Similarity
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
Mass
36.958 kDa
Sequence
MVKAKIAVNGYGTIGKRVADAVRAQDDMEVIGISKTKPNYEAAVAHQIGYDIYAPAANLEAFEKAGMPAAGTIEEMVEKADLVVDCTPGGIGEKNKPMYEKAGVKAIWQGGEDHSLAGFSFNAICNYEQAVGRDLVRVVSCNTTALCRAIYPIDKELGVKKARVVLARRATDPNDVKKGPINAIVPDPIKLPSHHGPDVKSVLPQINITSAALKIPTTLMHVHTVNMEVEKDCTVDDVKNIFGSQPRIRFVGQGMSSTAEIMEFARDMKRPRNDMWENCIWPESITVGDKELYFFQAVHQESIVVPENVDAIRAMMEFESDGAKSIEKTNKAIGLSKK

Gene
GAP1
Protein
Glyceraldehyde-3-phosphate dehydrogenase 1
Organism
Giardia intestinalis
Length
337 amino acids
Similarity
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
Mass
36.45 kDa
Sequence
MPIRLGINGFGRIGRMALRASLNIDGVQVVAINDPFTDCEYMEYMLKYDTVHGRFDGTIAHSEDSITVNGNKISVFKSMKPEEIPWGKTQVDIVLECTGRFTTKKDAELHITGGCKRVIISAPSADAPMFVCGCNLETYDPSTMKVISNASCTTNCLAPLAMVVNKKFGIKEGLMTTVHAVTATQLPVDGPSKKDWRGGRSCGANVIPSSTGAAKAVGKVLPALNGKLTGMAFRVPVPDVSVVDLTCTLEKDATYDEICAEIKRGSENELKGIMTYTNEDVVSSDFLSTTSTCNFDSKAGIMLNSRFVKLVAWYDNEFGYANKLVELAKYVGSKGCQ

Gene
gap1
Protein
Glyceraldehyde-3-phosphate dehydrogenase 1
Organism
Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
Length
334 amino acids
Function
Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG.
Similarity
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
Mass
35.005 kDa
Sequence
MTVRVGINGFGRIGRNVFRAAATRGADLEIVAVNDLGDVATMAHLLAYDSILGRFPEEVTAEPGAIRAGDTTVKVLAERDPAALPWGDLGVDVVIESTGIFTDAAKARAHVDGGAKKVIIAAPASNEDVTVVLGVNQDAYDPERHTIISNASCTTNCLGVLAKVLHDAVGIESGMMTTVHAYTQDQNLQDAPHKDLRRARAAGLNIVPTSSGAAKAIGLVLPELQGRLDAFALRVPVPTGSVTDLTVTASRSTTVEEVKEAYAKAAAGAYKGLLSYTEAPIVSTDIAGDPASCVFDAELTRVLGSQVKVVGWYDNEWGYSNRLIDLALLVGDTL

Gene
gap1
Protein
Glyceraldehyde-3-phosphate dehydrogenase 1
Organism
Bacillus cereus
Length
334 amino acids
Function
Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG.
Similarity
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
Mass
35.826 kDa
Sequence
MTKIGINGFGRIGRNVFRAALNNSEVEVVAINDLTDAKTLAHLLKYDTVHGTLNAEVSANENSIVVNGKEIKVIAERDPAQLPWSDYGVEVVVESTGRFTKKSDAEKHLGGSVKKVIISAPASDEDITVVMGVNHEQYDAANHNVVSNASCTTNCLAPFAKVLNEKFGVKRGMMTTIHSYTNDQQILDLPHKDLRRARAAAENMIPTSTGAAKAVALVLPELKGKLNGGAVRVPTANVSLVDLVVELDKEVTVEEVNAAFKAAAEGELKGILGYSEEPLVSIDYNGCTASSTIDALSTMVMEGNMVKVLSWYDNETGYSNRVVDLAAYMTSKGL

Gene
gap1
Protein
Glyceraldehyde-3-phosphate dehydrogenase 1
Organism
Bacillus cereus
Length
334 amino acids
Function
Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG.
Similarity
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
Mass
35.826 kDa
Sequence
MTKIGINGFGRIGRNVFRAALNNSEVEVVAINDLTDAKTLAHLLKYDTVHGTLNAEVSANENSIVVNGKEIKVIAERDPAQLPWSDYGVEVVVESTGRFTKKSDAEKHLGGSVKKVIISAPASDEDITVVMGVNHEQYDAANHNVVSNASCTTNCLAPFAKVLNEKFGVKRGMMTTIHSYTNDQQILDLPHKDLRRARAAAENMIPTSTGAAKAVALVLPELKGKLNGGAVRVPTANVSLVDLVVELDKEVTVEEVNAAFKAAAEGELKGILGYSEEPLVSIDYNGCTASSTIDALSTMVMEGNMVKVLSWYDNETGYSNRVVDLAAYMTSKGL

Gene
gap1
Protein
Glyceraldehyde-3-phosphate dehydrogenase 1
Organism
Streptomyces arenae
Length
333 amino acids
Function
Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG.
Similarity
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
Mass
34.946 kDa
Sequence
MTVRIGINGFGRIGRNVFRAAAARSSELEIVAVNDLGDVPTMAHLLAYDSILGRFPEEVTAEPGAIRVGDRTIKVLAERDPGALPWGDLGVDIVIESTGIFTDAAKARSHVDGGAKKVIIAAPASGEDFTVVLGVNDGDYDPERHTIISNASCTTNCLGVLAKVLHDAVGIDSGMMTTVHAYTQDQNLQDAPHKDLRRARAAALNIVPTSSGAAKAIGLVLPELAGRLDAFALRVPVPTGSVTDLTVTTRRGTSVEEVKEAYAAAASGPYKGLLSYVDAPLVSTDIVGDPASLFDAGLTRVCGPQVKVVGWYDNEWGYSNRLIDLATLIGSSL

Gene
GAP1
Protein
Glyceraldehyde-3-phosphate dehydrogenase 1
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Length
329 amino acids
Similarity
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
Mass
35.324 kDa
Sequence
MVKVAINGFGRIGRLVLRIALQRKALEVVAVNDPFISVDYAAYMFKYDSTHGRYKGEVTTSGNDLVIDGHKIAVFQEKDPANLPWGKLGVDIVIDSTGVFKELDSAQKHLDAGAKKVVITAPSKTAPMFVVGVNEDKYNGETIVSNASCTTNCLAPIAKIINDEFGIDEALMTTVHSITATQKTVDGPSHKDWRGGRTASGNIIPSSTGAAKAVGKVLPELQGKLTGMAFRVPTVDVSVVDLTVKLAKEATYDEIKAAVKKASQGKLKNVVGYTEDSVVSSDFLGDTHSTIFDASAGIQLSPKFVKVVAWYDNEYGYSERVVDLVEHVA

Gene
GAP1
Protein
Glyceraldehyde-3-phosphate dehydrogenase 1
Organism
Kluyveromyces marxianus
Length
329 amino acids
Similarity
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
Mass
35.253 kDa
Sequence
MVSIAINGFGRIGRLVLRIALERKNIDVVAINDPFISVDYAAYMFKYDSTHGKYKGEVSHDGSNLIINGKKVAVFQEKDPATLPWGKLGVDIAVDSTGVFKELDSAQKHIDAGAKKVVITAPSKTAPMFVVGVNEDKYNGEKIVSNASCTTNCLAPIAKIINDEFGIEEGLMTTVHSITATQKTVDGPSHKDWRGGRTASGNIIPSSTGAAKAVGKVLPELQGKLTGMAFRVPTTDVSVVDLTVKLVKAATYDEIKAAVKKVSEGKLKDVVGYTEDAVVSSDFLGDTHSTIFDAAAGIQLSPKFVKLVAWYDNEYGYSTRVVDLVEHVA

Gene
GAP1
Protein
GTPase activating protein 1
Organism
Oryza sativa subsp. japonica
Length
165 amino acids
Function
Mediates the transient calcium-dependent interaction of PYR/PYL/RCAR abscisic acid (ABA) receptors with the plasma membrane and thus regulates ABA sensitivity (By similarity). Stimulates the GTPase/ATPase activities of YCHF1, and regulates its subcellular localization (PubMed:19086295, PubMed:20876569, PubMed:23550829). Binds phospholipids in a Ca(2+)-independent manner (PubMed:20876569). Promotes tolerance towards salinity stress by limiting the accumulation of reactive oxygen species (ROS) (PubMed:19086295, PubMed:23550829). Promotes resistance to bacterial pathogens, such as Xanthomonas oryzae pv. oryzae and Pseudomonas syringae pv. tomato strain DC3000 (PubMed:19086295). Binding to YCHF1 is required for its role in stimulating defense responses and the ability to alleviate salt stress (PubMed:26286751).
Similarity
Belongs to the plant CAR protein family.
Mass
18.548 kDa
Sequence
MLGHLVGLVKVRVVRGVNLAVRDLRSSDPYVIVRMGKQKLKTRVIKKTTNPEWNDELTLSIEDPAVPVRLEVYDKDTFIDDAMGNAELDIRPLVEVVKMKIEGVADNTVVKKVVPNRQNCLAEESTIYISEGKVKQDVVLRLRDVECGEIELQLQWVDIPGSKGV