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gammaCOP

Gene
gammaCOP
Protein
Coatomer subunit gamma
Organism
Drosophila melanogaster
Length
883 amino acids
Function
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Required for limiting lipid storage in lipid droplets. Involved in the expansion of luminal extracellular matrices and apical membrane during tubulogenesis. Required in the tracheal epithelium for luminal protein secretion and diametric tube growth. In salivary glands, required for deposition of O-glycans and luminal extracellular matrix assembly. Required for epidermal morphogenesis and cuticle development.
Similarity
Belongs to the COPG family.
Mass
97.69 kDa
Sequence
MNYFSLTSHKKHRGHPSAGPSNAYQNLEKTSVLQETRTFNETPVNPRKCIHILTKILYLINQGEQLVAREATDCFFAMTKLFQSKDVVLRRMVYLGIKELSSIAEDVIIVTSSLTKDMTGKEDLYRAAAIRALCSITDNTMLQAVERYMKQCIVDKNAAVSCAALVSSLRLANTAGDVVKRWANEAQEALNSDNIMVQYHALGLLYHIRKSDRLAVSKLVNKLTRGSLKSPYAVCMLIRIACKLIEEEDIPSEELSDSPLFTFIESCLRHKSEMVIYEAAHAIVNLKNTNPRMLSPAFSILQLFCSSPKATLRFAAVRTLNKVAMTHPAAVTTCNLDLEGLITDSNRSVATLAITTLLKTGAESSVERLMKQISTFVAEISDEFKVVVVQAICALCTKYPRKHTVLMNFLSGMLREEGGLEYKTSIVDTIITIIEENADAKESGLSHLCEFIEDCEHVSLAVRILHLLGKEGPFAATPSKYIRFIYNRVILESPIVRAAAVTAMAQFGASCPALLSNILVLLGRCQMDPDDEVRDRATYYLSILNSERPELYKNYIIERENCSLALLEKSLVEHLNGDVDTRFDISIVPKAAIVKPVIANDVMLVTSSAPRPPKITREEESAARLAQLPGIQVLGPIHRSTAPIQLTESETEYTVQCIKHIFGQHVVFQFDCLNTLSDQILENVRVELTLPEGFTTRAVIPCPKLPYNDLQTTFVIVEFPPDAANSIATFGATLRFVVKDCDPNTGEPESEEGYDDEYMLEDLELTVADQIQKTRKNNFQVSWDAADSEEWLQAEDTFVLSAVTTLQDAVNTIVKILGLGAANLSENVPEGTHLHTLLCSGTFRGGAEILVRAKLALSEGVTLNLTVRSTDQDVAELITAAIG

Gene
gammaCop
Protein
Coatomer subunit gamma
Organism
Drosophila pseudoobscura pseudoobscura
Length
878 amino acids
Function
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Required for limiting lipid storage in lipid droplets. Involved in the expansion of luminal extracellular matrices and apical membrane during tubulogenesis. Required in the tracheal epithelium for luminal protein secretion and diametric tube growth. In salivary glands, required for deposition of O-glycans and luminal extracellular matrix assembly. Required for epidermal morphogenesis and cuticle development (By similarity).
Similarity
Belongs to the COPG family.
Mass
97.357 kDa
Sequence
MGSFRRDKEEEDDGPTNAYQNLEKTSVLQETRTFNETPVNARKCIHILTKILYLINQGETLVPREATDCFFAMTKLFQSKDVVLRRMVYLGIKELSSVAEDVIIVTSSLTKDMTGKEDLYRAAAIRALCSITDHTMLQAVERYMKQCIVDKNAAVSCAALVSSLRLATTAGDVVKRWANEAQEAMNSDNIMVQYHALGLLYHIRKSDRLAVSKLVNKLTRSSLKSPYAVCMLIRIACKLIEEEDIPSEELSDSPLFTFIETCLRHKSEMVIYEAAHAIVNLKNTNHRMLSPAFSILQLFCSSPKATLRFAAVRTLNKVAMTHPAAVTTCNLDLEGLITDSNRSVATLAITTLLKTGAESSVERLMKQISTFVAEISDEFKIVVVQAICALCTKYPRKHTVLMNFLSGMLREEGGLEYKTSIVDTIITIIEENADAKESGLSHLCEFIEDCEHVSLAVRILHLMGKEGPFAATPSKYIRFIYNRVILESPIVRAAAVTALSQFGASCPALLTNILVLLGRCQMDPDDEVRDRATYYLTILNTERADLYKNYIIERENCSLALLEKALVDHLNGDLEKRFDISVVPKAAAVVRAEISNDVMLVTSAPRPPKITREEESASRLAQLPGIQVLGPVHRSTAPIQLTESETEYTVQCIKHIFGQHVVFQFDCLNTLSDQFLENVRVELTLPEGFTTRAVVPCPKLPYNELQTTYVIVEFPPDAGSSIATFGATLRFVVKDCDPNTGEPDSEEGYDDEYMLEDMEITVADQIQKSKKNNFQVAWDAADSEEWLQAEDTFVLSAVTTLQDAVNTIMKILGLGSANLSEKVPEGTHLHTLLCSGTFRGGAEVLVRAKLALSEGVTLNLTVRSTDQDVAELITAAIG

Gene
gammaCop
Protein
Coatomer subunit gamma
Organism
Anopheles gambiae
Length
868 amino acids
Function
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).
Similarity
Belongs to the COPG family.
Mass
96.561 kDa
Sequence
MWRTKRGRTRRRDAGGNPWQNLEKTSVLQETRMFNETPVNARKCTHILTKILYLLNQGEVLGTREATECFFAMTKLFQSKDVVMRRMVYLGIKELSPIADDVIIVTSSLTKDMTGKEDLYRAPAIRALCSITDSTMLQAVERYMKQCIVDRNAPVSSGALVSSLHLASTAGEVVKRWANEAQEALNSDNIMVQYHGLGLLYHIRKADRLAVTKLVNKLTRQHLRSPYATCFLIRIACKIMEEEDASGNATEDSPLFNFVECCLRNKSEMVVYEAAHAVVNLKRTNPRELSTAVSILQLFCGSSKATLRFAAVRTMNKVAMLHPPAVNVCNLDLEGLIADSNRSVATLAITTLLKTGAESSVERLMKQIATFVAEISDEFKLVVVQAIRSLCTKFPRKHAVTMNFLSGMLREEGGLEYKTSIVDTIILIIEENPDAKEAGLGHLCEFIEDCEHTSLAVRILHLLGKEGPYSKCPSRYIRFIYNRVILENATVRAAAVAAIAQFGACCPDLLPNVLVLLNRCQMDCDDEVRDRATYYYTILNQSNPELNKRFIADHEIVSLPLLEKSLNEHLKGPLAERFDLSIVPKSQVIQPEVNEEVMIMNKAAPKIARVNREEVNTEKLLAIPGIHHVGALHKSCAPVQLTESETEYTVSCIKHCFAHHIVFQFDCVNTLSDQLLENVRVDLELPEGFVSRAVIPCAKLPYGDKESTYVIVQFPEDVPSSIATLGATLRFLVKDCDPATGQPDSDEGYNDEYILEDIEVTVADQMQKSKKQNFLAAWESADTEEWVEAEDTFELSSVTSLQDAVNTILKFLGLAPANLSENVPDGTFRGGVEVLVRSKLAVADGVTMQLTVRSTDMDVAELITSAVG