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fzd10-a

Gene
fzd10-a
Protein
Frizzled-10-A
Organism
Xenopus laevis
Length
586 amino acids
Function
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activated by Wnt8. Could have an antagonizing activity in the morphogenesis during development.
Similarity
Belongs to the G-protein coupled receptor Fz/Smo family.
Mass
65.579 kDa
Sequence
MDVSGVTGLLRGTALLLVLAAALCSAISSINPDRSGDGRCQAIEIPMCKDIGYNMTRMPNLMGHENQKEAAIQLHEFAPLVEYGCHSHLKFFLCSLYAPMCTEQVSTPIPACRVMCEQARLKCSPIMEQFNFKWPDSLDCSKLPNKNDPNYLCMEAPNNGTDETPRGSSMLPPIFRPQRPSSGHEIYPKDPTSRSSCENSGKFHHVEKSASCAPLCSSSVDVYWSKDDKKFAFIWIAIWSILCFFSSAFTVLTFLVDPLRFKYPERPIIFLSMCYCVYSVGYIIRLFAGADSIACDRDSGQLYVIQEGLESTGCTIVFLILYYFGMASSLWWVILTLTWFLAAGKKWGHEAIEANSSYFHLAAWAIPAVKTIMILVMRRVAGDELTGVCYVGSMDVNALTGFVLIPLACYLIIGTSFILSGFVALFHIRRVMKTGGENTDKLEKLMVRIGVFSVLYTVPATCVIACYFYERLNMDFWKILATQDKCKMDSQTKTLDCTMTSSIPAVEIFMVKIFMLLVVGITSGMWIWTSKTVQSWQNVFSKRLKKRNRSKPASVITSAGIYKKPQHPPKVHHGKYESALQSPTCV