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futsch

Gene
futsch
Protein
Microtubule-associated protein futsch
Organism
Drosophila melanogaster
Length
5495 amino acids
Function
During embryogenesis, necessary for dendritic and axonal organization and growth at the neuromuscular junction through the regulation of the synaptic microtubule cytoskeleton. Microtubule hairpin loops are found within a small subset of synaptic boutons at the neuromuscular synapse, these loops are stabilized by Futsch. Loop morphology and dynamics suggest that rearrangement of these microtubule-based loops is a critical component of the process of bouton division and for subsequent nerve-terminal growth and branching. Translation is repressed by Fmr1.
Mass
592.078 kDa
Sequence
MGDQPKATTTATGGAAGPVPEGDAVMATTNQDALAKGAGDGPAQDAAQEPGQAEHGEPGDGGDGGDDGATDAGASSLPPSEIGGRAPLDTACSDADGGAPSSLAGGIVGPPSPLTGCYLLIVLGEPHSEEHKDNILQHLLKGFLSWDVSDCHVDLEEELNTITQHAPEGEEARHGERLIQYASENLVTEVLIHPQYNTLIQCMRNLLSSFTRHRHIIHAGYTFSGNGSWILQDGTFSVADFSEAFQEHDVQRVIRAYADTITMNIHCADAGLWHTLPEKAFARQCRIRINPVDVLDTSSECINGFIDYLAPMVMPTSLRELLETSDVVGNIRFTHPTLYVFPGGQGDAALFGINGFNMLVDGGFNRKACFWDFARHLDRLDAVLMTRLNNSNVQGLGAVVSRKRDAHVYPQIGHFFGNVPDRKGLPSPDGDKDRDPLLIDLFERGHGIVSDLKALDLKPQCCYRNQEPVNLYHKVGHGTLDMYVISPARDSKEVKEFLQKWHAGDQRLFAARDSRDFNFPLQNLVSICALLVWQPANPDDTITRILFPGSTPDFKIQEGLEKLKHLEFMKHSTCTAKSIAPAIQTVTSTRKSLKSAIEATPAPPSASYKTTKFSPVASAALAVQHPQQQDNKAKEAAAAAAAAAAAAASAATIARAKADSMDTDAEPEHEADPEPADTGDEAAPTEQEPEAETEPEPEHEPEAEQDKDVGEEKKVEVLIMKPQQATPAVIAASGKDGVDAASADATPTGKLSKASAKGKADKPRAEVKPVVRSRIDTKPPKSMDRKLAKRDEKKSSPTTTPAARAPVAQNAKPKVLSRPATKSSPSSTPAKSAKEANNRKVLESKQQAARVQATSTVSRRVTSTASERRVQQQAEAKTAATGATQATQRKPISRRPRGVSPSKRAPAPGSPVKQAKPKAADLKKTRLDKGGTTDSSLVSTPSADEATAAKKLQDLTASQELDAEKQRELDDLKEEQEVVREIEAVFSRDEMKRQQHQQIKAELREMPAEGTGDGENEPDEEEEYLIIEKEEVEQYTEDSIVEQESSMTKEEEIQKHQRDSQESEKKRKKSAEEEIEAAIAKVEAAERKARLEGASARQDESELDVEPEQSKIKAEVQDIIATAKDIAKSRTEEQLAKPAEEELSSPTPEEKLSKKTSDTKDDQIGAPVDVLPVNLQESLPEEKFSATIESGATTAPTLPEDERIPLDQIKEDLVIEEKYVKEETKEAEAIVVATVQTLPEAAPLAIDTILASATKDAPKDANAEALGELPDSGERVLPMKMTFEAQQNLLRDVIKTPDEVADLPVHEEADLGLYEKDSQDAGAKSISHKEESAKEEKETDDEKENKVGEIELGDEPNKVDISHVLLKESVQEVAEKVVVIETTVEKKQEEIVEATTVITQENQEDLMEQVKDKEEHEQKIESGIITEKEAKKSASTPEEKETSDITSDDELPAQLADPTTVPPKSAKDREDTGSIESPPTIEEAIEVEVQAKQEAQKPVPAPEEAIKTEKSPLASKETSRPESATGSVKEDTEQTKSKKSPVPSRPESEAKDKKSPFASGEASRPESVAESVKDEAGKAESRRESIAKTHKDESSLDKAKEQESRRESLAESIKPESGIDEKSALASKEASRPESVTDKSKEPSRRESIAESLKAESTKDEKSAPPSKEASRPGSVVESVKDETEKSKEPSRRESIAESAKPPIEFREVSRPESVIDGIKDESAKPESRRDSPLASKEASRPESVLESVKDEPIKSTEKSRRESVAESFKADSTKDEKSPLTSKDISRPESAVENVMDAVGSAERSQPESVTASRDVSRPESVAESEKDDTDKPESVVESVIPASDVVEIEKGAADKEKGVFVSLEIGKPDSPSEVISRPGPVVESVKPESRRESSTEIVLPCHAEDSKEPSRPESKVECLKDESEVLKGSTRRESVAESDKSSQPFKETSRPESAVGSMKDESMSKEPSRRESVKDGAAQSRETSRPASVAESAKDGADDLKELSRPESTTQSKEAGSIKDEKSPLASEEASRPASVAESVKDEAEKSKEESRRESVAEKSPLPSKEASRPASVAESIKDEAEKSKEESRRESVAEKSPLPSKEASRPASVAESIKDEAEKSKEESRRESVAEKSPLPSKEASRPASVAESIKDEAEKSKEESRRESVAEKSPLPSKEASRPASVAESIKDEAEKSKEESRRESVAEKSPLPSKEASRPASVAESIKDEAEKSKEESRRESVAEKSPLPSKEASRPASVAESIKDEAEKSKEESRRESVAEKSPLPSKEASRPASVAESIKDEAEKSKEETRRESVAEKSPLPSKEASRPASVAESIKDEAEKSKEESRRESAAEKSPLPSKEASRPASVAESVKDEADKSKEESRRESMAESGKAQSIKGDQSPLKEVSRPESVAESVKDDPVKSKEPSRRESVAGSVTADSARDDQSPLESKGASRPESVVDSVKDEAEKQESRRESKTESVIPPKAKDDKSPKEVLQPVSMTETIREDADQPMKPSQAESRRESIAESIKASSPRDEKSPLASKEASRPGSVAESIKYDLDKPQIIKDDKSTEHSRRESLEDKSAVTSEKSVSRPLSVASDHEAAVAIEDDAKSSISPKDKSRPGFVAETVSSPIEEATMEFSKIEVVEKSSLALSLQGGSGGKLQTDSSPVDVAEGDFSHAVASVSTVTPTLTKPAELAQIGAAKTVSSPLDEALRTPSAPEHISRADSPAECASEEIASQDKSPQVLKESSRPAWVAESKDDAAQLKSSVEDLRSPVASTEISRPASAGETASSPIEEAPKDFAEFEQAEKAVLPLTIELKGNLPTLSSPVDVAHGDFPQTSTPTSSPTVASVQPAELSKVDIEKTASSPIDEAPKSLIGCPAEERPESPAESAKDAAESVEKSKDASRPPSVVESTKADSTKGDISPSPESVLEGPKDDVEKSKESSRPPSVSASITGDSTKDVSRPASVVESVKDEHDKAESRRESIAKVESVIDEAGKSDSKSSSQDSQKDEKSTLASKEASRRESVVESSKDDAEKSESRPESVIASGEPVPRESKSPLDSKDTSRPGSMVESVTAEDEKSEQQSRRESVAESVKADTKKDGKSQEASRPSSVDELLKDDDEKQESRRQSITGSHKAMSTMGDESPMDKADKSKEPSRPESVAESIKHENTKDEESPLGSRRDSVAESIKSDITKGEKSPLPSKEVSRPESVVGSIKDEKAESRRESVAESVKPESSKDATSAPPSKEHSRPESVLGSLKDEGDKTTSRRVSVADSIKDEKSLLVSQEASRPESEAESLKDAAAPSQETSRPESVTESVKDGKSPVASKEASRPASVAENAKDSADESKEQRPESLPQSKAGSIKDEKSPLASKDEAEKSKEESRRESVAEQFPLVSKEVSRPASVAESVKDEAEKSKEESPLMSKEASRPASVAGSVKDEAEKSKEESRRESVAEKSPLPSKEASRPASVAESVKDEADKSKEESRRESGAEKSPLASKEASRPASVAESIKDEAEKSKEESRRESVAEKSPLPSKEASRPTSVAESVKDEAEKSKEESRRDSVAEKSPLASKEASRPASVAESVQDEAEKSKEESRRESVAEKSPLASKEASRPASVAESIKDEAEKSKEESRRESVAEKSPLASKEASRPTSVAESVKDEAEKSKEESSRDSVAEKSPLASKEASRPASVAESVQDEAEKSKEESRRESVAEKSPLASKEASRPASVAESVKDDAEKSKEESRRESVAEKSPLASKEASRPASVAESVKDEAEKSKEESRRESVAEKSPLPSKEASRPTSVAESVKDEAEKSKEESRRESVAEKSSLASKKASRPASVAESVKDEAEKSKEESRRESVAEKSPLASKEASRPASVAESVKDEAEKSKEESRRESVAEKSPLPSKEASRPTSVAESVKDEADKSKEESRRESGAEKSPLASMEASRPTSVAESVKDETEKSKEESRRESVTEKSPLPSKEASRPTSVAESVKDEAEKSKEESRRESVAEKSPLASKESSRPASVAESIKDEAEGTKQESRRESMPESGKAESIKGDQSSLASKETSRPDSVVESVKDETEKPEGSAIDKSQVASRPESVAVSAKDEKSPLHSRPESVADKSPDASKEASRSLSVAETASSPIEEGPRSIADLSLPLNLTGEAKGKLPTLSSPIDVAEGDFLEVKAESSPRPAVLSKPAEFSQPDTGHTASTPVDEASPVLEEIEVVEQHTTSGVGATGATAETDLLDLTETKSETVTKQSETTLFETLTSKVESKVEVLESSVKQVEEKVQTSVKQAETTVTDSLEQLTKKSSEQLTEIKSVLDTNFEEVAKIVADVAKVLKSDKDITDIIPDFDERQLEEKLKSTADTEEESDKSTRDEKSLEISVKVEIESEKSSPDQKSGPISIEEKDKIEQSEKAQLRQGILTSSRPESVASQPESVPSPSQSAASHEHKEVELSESHKAEKSSRPESVASQVSEKDMKTSRPASSTSQFSTKEGDEETTESLLHSLTTTETVETKQMEEKSSFESVSTSVTKSTVLSSQSTVQLREESTSESLSSSLKVEDSSRRESLSSLLAEKGGIATNTSLKEDTSASASQLEELLVQSEECSSESIVSEIQTSIAQKSNKEIKDARETKVTSQFTTTTSSATKDDSLKETVAEFLATEKIVSAKEAFSTEATKSADDCLKKTTASAVSSTSASQRALFVGTDESRRESLLSQASESRLTHSDPEDEEPADDVDERSSVKESRSKSIATIMMTSIYKPSEDMEPISKLVEEEHEHVEELAQEVTSTSKTTTLLQSSEQSSTTTSSTSKTGASRVESITLTQMDQQTSQSQGDPADRKTPPTAPVSPGVKAMSSTGSAGSVIGAGAGAVAAGGKCESSAASIVSSSGPMSPKDISGKSSPGALTSESQSIPTPLGRESHTDTPESSPKPTSPFPRVSKDELKSLEMQHHSQEQMLAGAAAAAGAECEGDIPELHELRGLECTTALSGSTDKIITTTITTVTKVISADGKEIVTEQKTVTTTDSSEPDSEKVVVTTTRTTSESERDQLLPKEVALLRGLYRASTPGSEDDEDLLLGSPRSATSYELQHSSSGVSKRSDLDADGDESQDDIPPQYGSEEHSTARSILLPRTADPMATSFYGALPDSFDVVMKPSTEPIPIQGAPSGDSQSSESVESSSQTWAGHKFLDQADKDFQRALEEHVQARGAEVMSSVTAKYSYSPSKAEEMEQIVSGTAERQRFPLSDVQRARVAESGFATVGSVASQQQQQEKGGEVEQAVPTTTAVTASTTATASSTGALPKDRLEEWGKPLGLPSPAPLPVEGGADIRTTPKKERRLVATKTRLNNEKNLRRRSESPNKAGKKPAPVYVDLTYVPHNGNSYYAHVDFFKRVRARYYVFSGTEPSRQVYDALLEAKQTWEDKELEVTIIPTYDTDVLGYWVAENEELLAKHRIDLSPSASRCTINLQDHETSCSAYRLEF