Protein
Tryprostatin B 6-hydroxylase
Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)
Function
Catalyzes the conversion of tryprostatin B to 6-hydroxytryprostatin B in the biosynthesis of indole alkaloids such as tryprostatins, fumitremorgins and verruculogen.
Similarity
Belongs to the cytochrome P450 family.
Sequence
MPSVMKCGYLATAGLIGICIHLWYFRYGEHHLYPWRYVRFHLCLTMGVSALLYAKKPPQYTLSPGDLVKDTCLLMVTYLIGLFTSLLLYRTLFHPLRQIRGPWAAKVSSFWLSFRLRRGPSFRILHELHEEYGPVVRVGPSEVSIIHPEAIGIIYGPNSRCSKNAFYDNGHPMMSLHSYRDRTAHDQRRRVWSAGFGDRALRGYEQRMRVYRQKLFQRLEERADAESTINISQWFNFYSYDTMGDLAFARSFDMLDASRNHWAVDMLMHGMIGYRYLFPSWFFRLLATMPSLSNDWHKFIGFATDTMLRRLREQVGVPDIFASLLAPLNGRDPTDDERNMLMGDAMLIITAGSDTTATSLTSIVYELARRPDEVDKLRAEIEPIEADSDGEYQHDTLAKLPHLNGFINEAFRLHSPIPGVIPRKTPPEGIHVKDIFIPGNMTVFSPQWSMGRSEAAYVDPAIFNPERWYKHIDLVKEKSVFAPFSIGPYSCIGKPLAMMNIRTTVARLIMRFDVRFPEGEDGIRWMDAADEHFAMGIHQMPVVLTRRH