fsn-1

Gene

fsn-1

Protein

F-box/SPRY domain-containing protein 1

Organism

Caenorhabditis briggsae

Length

332 amino acids

Function

Component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which is required for the restriction and/or maturation of synapses in GABAergic neuromuscular junction (NMJ) presynaptic neurons. Promotes NRJ synapse development and synaptic transmission by negatively regulating the daf-2/InsR pathway in muscles. By targeting convertase egl-3 for degradation, negatively modulates insulin-like protein ins-4 and ins-6 processing. May stabilize synapse formation by promoting the down-regulation of scd-2. Regulates axon termination in PLM and ALM neurons.

Similarity

Belongs to the FBXO45/Fsn family.

Mass

37.225 kDa

Sequence

MTENNEETIVPDEQCNLTSSTPMKSSDLENVESPIERKISIVECDGEGNPPIESSEETPPDLTSHSVAPRRRRSPRRPEVSASRLPLKVLNQIFQYLSLKDLRSAMLTCHSWNNALSMEDSDIWQQLLVQKLPEAAHSDPFLFVELRSARKKLRAWYFAWNTNDISRNNYIRTNGFTVHRQPVAQSTDGVRGKRGVSQGVHAFDITWDGPLGTVAVVGFATKHAALHCVGYIALLGSDDQSWGWNLVDNVLMHNGVQLGVYPKMNNPPKYEVGEKIRLVIDCDMHVAYFERNSEFLGIAFSHIPPLRLFPAVCAVYGNTEVTMVYVGSPQMG

Protein

F-box/SPRY domain-containing protein 1: fsn-1

Gene

fsn-1

Protein

F-box/SPRY domain-containing protein 1

Organism

Caenorhabditis elegans

Length

332 amino acids

Function

Component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which is required for the restriction and/or maturation of synapses in GABAergic neuromuscular junction (NMJ) presynaptic neurons (PubMed:15208641, PubMed:23665919). Promotes NRJ synapse development and synaptic transmission by negatively regulating the daf-2/InsR pathway in muscles (PubMed:23665919). By targeting convertase egl-3 for degradation, negatively modulates insulin-like protein ins-4 and ins-6 processing (PubMed:23665919). May stabilize synapse formation by promoting the down-regulation of scd-2 (PubMed:15208641). Regulates axon termination in PLM and ALM neurons (PubMed:21968191).

Similarity

Belongs to the FBXO45/Fsn family.

Mass

36.825 kDa

Sequence

MAENDGETIVPDEQCNLTASTPMKSSGLEQVESPKERKTSMVECDDEGNPSSGTPDESPKQLTPHSIPPRRRRSPRRPEVSASRLPLKVLNQIFQYLPLKDLRSAMLTCHSWNNALSMEDSDIWQYLLGKKLPEAAVSDPFLLAELGSAKKKLRAWYFAWNTSDISRNNYIRTNGFTVHRQPVAQSTDGVRGKRGISKGVHAFDITWDGPLGTVAVVGIATKHAALHCVGYVALLGSDDQSWGWNLVDNVLMHNGAQLGVYPKMNNPPKYEVGDKIRLIIDCDTHVAYFERNSEFLGIAFNHIPPLRLYPAVCAVYGNTEVTMVYVGSPQMG

Protein

F-box/SPRY domain-containing protein 1: fsn-1