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frmd8

Gene
frmd8
Protein
FERM domain-containing protein 8
Organism
Danio rerio
Length
471 amino acids
Function
Promotes the cell surface stability of rhomboid 5 homologs and prevents their degradation via the endolysosomal pathway. By acting on rhomboid 5 homologs, involved in ADAM17-mediated ligand shedding (By similarity). Negatively regulates the Wnt/beta-catenin signaling pathway (PubMed:19572019).
Mass
52.227 kDa
Sequence
MEGDDGDFPPEPSEHSLSQRGSVASSVTRAQDLLVYLANDSAVHLTLEGLGCMNAQELGRSVREALNIPNSAADVFAFWFCSPLLELQLKPKHLPYKLCRQWQDLLYRFTEAPTEDISLDEPSLLFKRSVFYPRAKELQIEDEGVLRLLYDEAKMNILEGRYPCDPEHWLTLGALSCAIELGTELDDQALTAAIREKKLSSFLPAHAALGGGGFLSTLRGRGGRNAEMEQNLVKECRSVCSSAASGSSQEPIALLRQYLRSCHNLPYYGCAFFAGEIDKPAQGLLHRGGRKAVSVGISLEGVYVMDVKEKHVLLGLKFTELSWDHSYPETEGDSHILWLEFDGEEAGTPVNKLLKIYSKQAELMSGLIEFCVELRSVSESAATGTDGEVTPSHEPTSPETNNKTRERRQGKLRRQNSVVCSRVHSLSTINYVDDGKEIKRLKPKRAASFFTRQAQPPTYSAVQVTESLEQG

Gene
Frmd8
Protein
FERM domain-containing protein 8
Organism
Mus musculus
Length
466 amino acids
Function
Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway (PubMed:29897333). By acting on iRhoms, involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface (By similarity). Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6 (By similarity).
Mass
51.828 kDa
Sequence
MEGAEGNAGQPGPAERSHRSSVSSVGARAADVLVYLADDTVVPLAVENLSSISAHELHRAVREVLQLPDVALEAFALWLVSPLLEVQLKPKHQPYKLGRQWPELLLRFTNASDDDVAMDEPSLQFRRNVFFPRRRELQIHDEEVLRLLYEEAKGNVLTARYPCDLEDCEVLGGLVCRVQLGPYQPGQPAACTLREKLDSFLPAHLCKRGHGLFAAFRGRGAKTGPGEQGLLNAYRQVKEVTGNNSEREATLGSHYRAYLLKCHELPFYGCAFFHGEVDKPAQGFLHRGGRKPVTVAISLEGVHVIDNREKHVLLGLRFQELSWDHTSPEEEEPVLWLEFDGDSEGTPVNKLLRIYSKQAELMSGLIEYCIELSQAAEPTLSQESASGPHEAPSPSPPPTQRPKLRRQGSVVCSRIQHLSTIDYVEDGKGIKRVKPKRTTSFFSRQLSSSQGSYTVVQPTDDSLEQS

Gene
Frmd8
Protein
FERM domain-containing protein 8
Organism
Rattus norvegicus
Length
466 amino acids
Function
Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on iRhoms, involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface (By similarity). Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6 (By similarity).
Mass
51.782 kDa
Sequence
MEGAEGNAGQPGPAERSHRSSVSSVGARAADVLVYLADDTVVPLAVENLSSISAHELHRAVREVLQLPDMALEAFALWLVSPLLEVQLKPKHQPYKLGRQWPELLLRFTDASDDDIAMDEPSLQFRRNVFFPKRRELQVHDEEVLRLLYEEAKGNVLTARYPCDLEDCEVLGGLVCRVQLGPYQPGQPAACTVREKLDSFLPAHLCKRGHGLFAAFRGRGAKTGPCEQGLLNAYRQVKEMAGGDSERETTLGSHYRAYLLKCHELPFYGCAFFHGEVDKPTQGFLHRGGRKPVTVAISLEGVHVIDNREKHVLLGLRFQELSWDHTSPEEEEPVLWLEFDGDSEGTPVNKLLRIYSKQAELMSVLIEYCIELSQAAEPALPQESASGPQEAPSPSSAPTQRPKLRRQGSVVCSRIQHLSTIDYVEDGSGIKRVKPKRTTSFFSRQLSSSHGSYTVVQPNDNSPEQG

Gene
FRMD8
Protein
FERM domain-containing protein 8
Organism
Homo sapiens
Length
464 amino acids
Function
Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on iRhoms, involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface (PubMed:29897333, PubMed:29897336). Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6 (PubMed:19572019).
Mass
51.218 kDa
Sequence
MDGTEGSAGQPGPAERSHRSSVSSVGARAADVLVYLADDTVVPLAVENLPSLSAHELHRAVREVLQLPDIALDVFALWLVSPLLEVQLKPKHQPYKLGRQWPELLLRFTSAPDDDVAMDEPFLQFRRNVFFPKRRELQIHDEEVLRLLYEEAKGNVLAARYPCDVEDCEALGALVCRVQLGPYQPGRPAACDLREKLDSFLPAHLCKRGQSLFAALRGRGARAGPGEQGLLNAYRQVQEVSSDGGCEAALGTHYRAYLLKCHELPFYGCAFFHGEVDKPAQGFLHRGGRKPVSVAISLEGVHVIDSREKHVLLGLRFQELSWDHTSPEEEEPILWLEFDGDSEGTPVNKLLKIYSKQAELMSSLIEYCIELSQAAEPAGPQDSATGSPSDPSSSLAPVQRPKLRRQGSVVSSRIQHLSTIDYVEDGKGIRRVKPKRTTSFFSRQLSLGQGSYTVVQPGDSLEQG

Gene
frmd8
Protein
FERM domain-containing protein 8
Organism
Xenopus laevis
Length
452 amino acids
Function
Promotes the cell surface stability of RHBDF1 and RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on RHBDF proteins, involved in ADAM17-mediated ligand shedding (By similarity). May negatively regulate Wnt signaling (By similarity).
Mass
51.584 kDa
Sequence
MDGSETSHSSGLNDFLLRSSVSSGSRSMDVIIYLINDEVIQLTVDGLSVITAHELHKSIREALQLPETAQDVFALWLISPLLEVQLKPKHQPYKVCRQWHDLLARFTNCSSNDILQDEPYLQFRRNIFLPKARELQISHERILYLLYEEAKYNVLEGRYPCDVEDCEVLGGLACRLELGPYNQNEHTPATIRPKLDTLFPPYLCKKRNGGLLTTFKNRGGRQASFEQTVLNTYKEVKETSACTDEQAMKNHYKEYLKKCHELPYYGCAFFQGDVDKPAQGFLNRSGRKAVSVSVNLEGVSVIDRKEKHVLISLTYPELSWDHTYPDEDEHILWLEFDGESEGTPVNKLLKIYSKQAELMSGLIEYCIELSQSTESPASDSTPGNSQLSEKRSKLKRQESVLCNRMKHLTTIDYVEDGAKITRVKPKRTASFFTRQNTHNYSAVQPSETPTES

Gene
frmd8
Protein
FERM domain-containing protein 8
Organism
Xenopus tropicalis
Length
450 amino acids
Function
Promotes the cell surface stability of RHBDF1 and RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on RHBDF proteins, involved in ADAM17-mediated ligand shedding (By similarity). May negatively regulate Wnt signaling (By similarity).
Mass
51.634 kDa
Sequence
MDGSETSHSSGLNDFLLRSSVSSGSRSMDVIVYLINDEIIQLTVDGLSVITAHELHKSIREALQLPETAQDVFALWLISPFLEVQLKPKHQPYKVCRQWHDLLARFTNCSSNDILQDEPFLQFRRNIFFPKARELQIAHERTLYLLYEEAKYNVLDGRYPCDVEDCELLGGLACRLELGPYNQNEHTPATIRPKLDSLFPPYLCKKRNGFFTTFKNKGGRQASFEQTVLNTYKEVKESSACTEEQAMKNHYREYLKKCHELPYYGCAFFHGVVDKPAQGFLNRSGRKPVSVAINLEGVSVIDRKEKHILISLTYPELSWDHTYPDEEEHILWLEFDGDAEGTPVNKLLKIYSKQAELMSGLIEYCIELSQTTESPASDFLPGNSQLSEKRSKLRRQESVLCNRMKHLNTIDYVEDGASIKRVKPKRTASFFTRQNTHYSAVQPSETPTET