Protein
Fer-related kinase 1
Organism
Caenorhabditis elegans
Function
Non-receptor tyrosine-protein kinase which plays a role in morphogenesis by regulating the epidermal enclosure of the embryo, independently of its kinase activity (PubMed:15958510). Prevents hyperactivation of the Wnt signaling pathway during endoderm development, probably by preventing hmp-2 nuclear translocation (PubMed:20805471).
Similarity
Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.
Sequence
MGTVEKSSNNDASVTDDIRSAEYYHGMVPRQDAEGFLKREGDFLVRKTEQMPGKVVLAMSVRVTDELCRHFMLNMDPTSNKFYFEHTHQESTISELINWHMTTKTPISAASGAKIRRPMERSPWLINHDSIVANKKLGEGAFGDVFIAELDQGGKQEVAVKTMRAEATREARLRFMKEARLMRKYQHKHVVKLIGVAIHEHPLMIVMEYCPNGSLLSHLKKNKVSLIEKLRFTTEAADGIAYLERSKCIHRDIAARNCLLSAKNELKISDFGMSDNKDEIKDETLEKVPIKWLAPETMQEKVYTHKTDIWTFGVLVWEIYSDGAEPYPGLTKIQTRAKIVVNDYRMKMPDGTHPTVADVVTGTCWQKNPEKRSTMDSIHKKLREFYESKK