fpoH

F(420)H(2) dehydrogenase subunit H

350 amino acids

Component of the F(420)H(2) dehydrogenase (FPO complex) which is part of the energy-conserving F(420)H(2):heterodisulfide oxidoreductase system. The membrane-bound electron transfer system of the complex plays an important role in the metabolism of methylotrophic methanogens when the organisms grow on methanol or methylamines. Catalyzes the oxidation of methanophenazine to dihydromethanophenazine. It shuttles electrons from F(420)H(2), via FAD and iron-sulfur (Fe-S) centers, to methanophenazine (an electron carrier in the membrane). It couples the redox reaction to proton translocation (for every two electrons transferred, two hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. It also catalyzes the oxidation of F(420)H(2) with quinones such as 2,3-dimethyl-1,4-naphthoquinone, 2-methyl-1,4-naphthoquinone and tetramethyl-p-benzoquinone.

Belongs to the complex I subunit 1 family.

38.443 kDa

MTFMAIEIPEFIVPFVPWIRGTVGLVLVGAIFLGGMAAVWIERKLSADIQLRYGPSRVGKFGLLQLVADAIKLFTKEDVRPGNADRFLYDNAPVFMLTSLFLMLVAIPVGAVFIDGNLYPLAVTEMDISILFIEAVSAINIFGIFMAAYGSNNKYSLLGAFRNFARMIGYEVPLGIAIVSVAVMTGSLNIIDITSAQGSFVWNIFLQPIGFVVFFIALMADLGRLPFDQNESEEELVAGWVTEYTGMRFGLVFFAEYMHMILGSFLVALLFLGGWNVPAFVANNAVLGLIAPTGILLLKTVLVLMTIIGMRWAVPRFRIDQVVDMSWKKLLPLSLLNLAWAVGLGLYLGA

fpoH

F(420)H(2) dehydrogenase subunit H

348 amino acids

Component of the F(420)H(2) dehydrogenase (FPO complex) which is part of the energy-conserving F(420)H(2):heterodisulfide oxidoreductase system. The membrane-bound electron transfer system of the complex plays an important role in the metabolism of methylotrophic methanogens when the organisms grow on methanol or methylamines. Catalyzes the oxidation of methanophenazine to dihydromethanophenazine. It shuttles electrons from F(420)H(2), via FAD and iron-sulfur (Fe-S) centers, to methanophenazine (an electron carrier in the membrane). It couples the redox reaction to proton translocation (for every two electrons transferred, two hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).

Belongs to the complex I subunit 1 family.

38.522 kDa

MNIMIEIPEFIIPLIPWIRGVVGLVLVGAIFLGAMGAVWLERKLSADIQFRYGPSRVGKFGLLQLVADAIKLFTKEDMRPRNADRLLFDNAPIFMMSSVFLMLVAIPVGAVFINGVEYPLAVTEMDISVLYIEAMSAITIFGIFMIAYGSNNKYSLLGAFRNFARMVGYEVPLGITVVSVAIMTGSLNIVEIASAQGLLWNIFLQPIGFIVFFIALMADMGRLPFDQNESEEELVAGWITEYTGMRFGLGFFAEYIHMILGSFLVALLFLGGWNVPAFVANNPVLGLIAPTGFFLLKTVLVLMTIIGMRWAVPRFRIDQVVDLSWKRLLPLSLLNLVWAVGLGLYLGA

fpoH

F(420)H(2) dehydrogenase subunit H

346 amino acids

Component of the F(420)H(2) dehydrogenase (FPO complex) which is part of the energy-conserving F(420)H(2):heterodisulfide oxidoreductase system. The membrane-bound electron transfer system of the complex plays an important role in the metabolism of methylotrophic methanogens when the organisms grow on methanol or methylamines. Catalyzes the oxidation of methanophenazine to dihydromethanophenazine. It shuttles electrons from F(420)H(2), via FAD and iron-sulfur (Fe-S) centers, to methanophenazine (an electron carrier in the membrane). It couples the redox reaction to proton translocation (for every two electrons transferred, two hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).

Belongs to the complex I subunit 1 family.

38.027 kDa

MTVVIPEYITPLIPWVRGIVGLVLIGVIFMGAMGAVWLERKLSADIQTRMGPCRVGKYGLLQLVADAIKLFTKEDLKPLNADSLLFNNANIFMLGSVFLMLVALPVGAVFINGVEYPLAVTQMDISVLYIEAVSALSIFGIFMVAYGSNNKYSLLGAFRNFARMVGYEVPLGITVISVAAMTGSLNIVDISTAQGLHWNIFLQPLGCFVFFVSLMADMGRLPFDQNESEEELIAGWITEYCGMRFGLGFFAEYIHMILGSFLVALLFLGGWNVPGFIANNSFFGIIVPTGFLIVKVVFVLMVIIGLRWAVPRFRIDQVVDLSWKKLLPLALLNLVWAVGLGLYLGA