Protein
Dihydropteroate synthase
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Function
Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
Similarity
Belongs to the DHPS family.
Sequence
MKLYANNKCLDLSVPQIMGILNFTPDSFSDSGQFFSLDKALFQVEKMLEEGATIIDIGGESTRPNADEVSEQEELHRVVPVVEAVRNRFDCWISVDSSKAVVMREAANVGMDLINDIRALQEPNALETAVKLALPVCIMHMQGQPRTMQANPYYENVVQDVLAFLQKRTNECLSAGIKKENLIWDMGFGFGKSVQHNYQLLQNLNEFCQIGYPVLAGLSRKSMIGAVLDKPVDQRIIGSAAGALIAVQKGAKILRVHDVAATSDMLKVWQATANA