folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Sphingobium chlorophenolicum

Length

316 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

33.363 kDa

Sequence

MASIISGTAAAEGLLADLTRDVARFSQVHGYAPTLVAVLVGDDPASHIYVRKKIEQCRKVGMESVEHRLPADCSEEDLLALIASLNADERVHGILVQLPLPAQIDSGKVLDTIDPRKDVDGFHPVNVFRLSTGTGGLVPCTPMGCMILLRSVLPDLKGKQAVVIGKSNIVGKPVAMLLLEQGCTVTVCGRHTRNLAEVCRNADIIVAAAGTPHLVKGYWVKAGAVVIDVGINRIALDDGRSRIVGDVASDEIGHAAAFTPVPGGVGPMTIACLAAEYVQAARRRAWCWRRTNRHSFSLEGEGYGALLSGAKLGAVG

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Treponema pallidum (strain Nichols)

Length

315 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

32.819 kDa

Sequence

MDARLIDGKQAAHECTARLATRVQALRAAVGTAPFLAAVLVGDDPASCTYVAAKQRALARAHLRGETHRLPAHASHAQVLELIARLNEDARVHGILIQLPLPAHLDAARVCRAVAPEKDVDGFHPLNCGALFLAQPGFVPCTPAGIVHLLRRAQVPLAGARVVIVGRSAIVGRPLAVLLASPGCDATVTLCHSHTRGLADICVQADILVAALGKARFIGAPFVRTGAVVIDVGIHHVPDATAPRGRRLCGDVDFDAVAHKVQAITPVPGGVGPMTIAMLLHNTLCAAEYAAGMIPPFRAALYADLDGRAAGDVPH

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Treponema pallidum subsp. pallidum (strain SS14)

Length

315 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

32.819 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)

Length

311 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

33.157 kDa

Sequence

MRFKYVASKYSCVTQTQTQLIDGTEVAASIRSDLISSVTRIVNTGTTPQLATVLMNDDPASQTYVSMKHDDCEEVGIATRDITIDPEAPAAELFDTVDELNADSSVHGILVQMPLPDHVDEREVLRRIDPKKDVDGFHPENVGRLVAGQPRYKPCTPHGIQKLLIAADIETEGANAVVIGRSNIVGKPMANLLIQKADAGNATVTTCHSRTNNLASKTRDADIIIAAAGVPEMIDGDMISTGTVVIDVGINRVETENGSELVGDVEFESAAKKADAITPVPGGVGPMTRAMLLWNTVKATAIATDTSIELP

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Pyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827)

Length

311 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

34.926 kDa

Sequence

MVTWIRGEELHARTKEWARSHVKRLEEVGITPKLAVLLLNDDPVELETQRRFVTLKARDVREIGGEVEIYELYSAPPERRTKEALRLIESLNRRDDVTGVIIQKPLPPFVDEKALFSALSPEKDVDALTPENKKRLLTDFDLDRDVLPCTPAGILELFKLYGIDVRGKDVVVVGKGELVGKPLAVMLMQLDATVTVLHALSKEREPYVKRADIVISAVGRPPELYKDNPWRLTGDMIKEGAVVVGVGGKVDPATKRWFFDVDEKSVAEKASYLTPNIGGVGLATRARVLKNLIRTTYQVAQRVLSPRLYEV

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321)

Length

311 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

34.681 kDa

Sequence

MVTWIRGEGLHRQAKEWAREHVKRLEEVGITPKLAIILLNDDPVELATQRRFASLKARDVREVGGEAEIYELHDVPPERRTKEALRLIESLNKRDDVTGVIIQKPVPPFVDERALFAALSPEKDVDALTPDNKKRLLDRFDLDNDVLPCTPAGILELFRMYGIEIRGKDVVVVGKGELVGKPLSVMLMQLDATVTVLHALSKEREPYVKRADIVISAVGRPPEIYRDNPWRLTGEMIKEGVVVVGVGGKVDPISGKWHFDVDEKSVAEKASYLTPNIGGVGLATRARVLKNLIRTSYQVARLVVSSRIVGP

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)

Length

311 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

34.856 kDa

Sequence

MVVWIKGDRLHTETLEWARRHVKELERYGVTPKLAVLLLNDDPIELETQHKYVSLKARDIKSIGGEVELFELYKEPPEKREVAALKLIERLNNADDVTGILVQKPLPPYVDETKIFERLSPLKDVDGLTPENKKRLVTGFDLDRDILPCTPAGILELFRQYKIDVRGKDVVVVGKGTLVGFPLSIMLMQLDATVTVLHALSKDRKYYVRNADIIISAVGRPPELYSDNPWKLTGDFIKEGAVVVGVGGKVDPVTKKWYFDVDEKSVAEKASYLTPNIGGVGLATRARLVKNLIITSYMVATRVASPRLLAL

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / V24Sta)

Length

311 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

34.931 kDa

Sequence

MVVWIRGDRLHAETLQWARRHVEELERFGVTPKLAVLLLNDDPVELETQRRYVSLKAKDVRSIGGEVEIYELYKEPPERREAAALRLIERLNNADDVTGVLIQKPLPPYIDEGRLFERLSPIKDVDGLTPENKKRLVAGFDLDRDILPCTPAGILELFRQYQVEVRGRDVVVVGKGTLVGFPLSIMLMQMDATVTTLHALSKDRAYYTRKADIVISAVGRPPELYGDNPWRLTGDMIKEGAVVVGVGGKVDPATKRWYFDVDENSVAEKASYLTPNIGGVGLATRARLVKNLIITTYMVLTRVTSPRLLSL

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Gluconacetobacter diazotrophicus (strain ATCC 49037 / DSM 5601 / PAl5)

Length

311 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

32.34 kDa

Sequence

MTDRTTDPVPAEPAPVRHPTARLIDGKAFAANLTQTIARDVQSFHDRYRVTPGLAVVLVGNDPASEVYVRNKALQTHRAGMRSFMHMLPATTSQAELLALIGRLNADPEIHGILVQLPLPAGLDPVAVTNAILPDKDVDGLGEVNAGRLALGQPGIVPCTPLGCLMLLKSELGDLRGLHAVIIGASNLVGRPMARLLLAEGCTVTVGHIDTRDPAALARQGDILVVATGCHGLVRGDWIKPGAAVIDVGITRISLPSGKTRLVGDVAFDEAVTRAGCITPVPGGVGPMTIACLLNNTLAAARRIVGATDAA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)

Length

308 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

34.032 kDa

Sequence

MGFKGYILSIVFNGKDFANKYYLMLKEFLKQHNLRDKIALKVVLANDEPASNLYVSIKSRVAKEIGLNVEVIKFSANSVQSDILEVIDRENKNLSTDGIIVQLPLLKGMDLNSILNSIVYSKDVDGLSFVNLGKMILGDKKGFIPCTALAVLKILRDEGIKTLGKTVVVVGRSPLVGRPISILLSSKPYDATVIVCHSKSIYLDVYLRQADIVISAVGKPRLIDKSMLCGKPYVIDIGISEIETDNGKILSGDTDFDNIKECVKFITPVKGGIGPVTVLMLMFNTIKAHLINNRMFDVLNRLEKLLEV

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Borrelia burgdorferi (strain ZS7)

Length

308 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

34.004 kDa

Sequence

MGFKGYILSIVFNGKDFANKYYLMLKEFLKQHNLRDKIALKVVLANDEPASNLYVSIKSRVAKEIGLNVEVIKFSANSVQSDILEVIDRENKNLSTDGIIVQLPLLKGMDLNSILNSIVYSKDVDGLSFVNLGKMILGDKKGFIPCTALAVLKILRDEGIKTLGKTVVVVGRSPLVGRPISILLSSKPYDATVIACHSKSIYLDVYLRQADIVISAVGKPRLIDKSMLCGKPYVIDIGISEIETDNGKILSGDTDFDNIKECVKFITPVKGGIGPVTVLMLMFNTIKAHLINNRMFDVLNRLEKLLEV

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Pyrobaculum calidifontis (strain JCM 11548 / VA1)

Length

308 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

34.389 kDa

Sequence

MSGKPLHEKTKEWARRHVRLLEEVGVTPKLAVLLLNDDPVELETQRRYVSLKARDVREVGGEVEIYELVDVPPERRSKEALYLIERLNRRDDVTGILIQKPVPPFVDEDLLFQRLSPEKDVDALTPENKKRLLALFDLDRDLLPCTPAGILELLQMYGVEVKGRDVTVVGKGELVGKPLAVMLMQLDASVSVLHALTRDKLRYVKEADIVISAVGRPPELYRDNPWRLTGDMVKEGAVVVGVGGKVDPATGKWYFDVDEKSVAEKASYLTPNLGGVGLATRARLLKNLIRASYNVARATAAPRLLKAF

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Jannaschia sp. (strain CCS1)

Length

308 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

32.248 kDa

Sequence

MTEPQTNRTSGAKIIDGKAFAADVRGQVAGHVQRLKDEHGITPGLAVVLVGEDPASEVYVSHKHKATVEVGMTSFEHKLPADTSEDDLFALIDKLNADPAVHGILCQFPVPDHLDERRTVARISPAKDVDGLSVTNAGLLSSGGEALVSCTPLGCLMLLRAEFDSLSGKDAVVIGRSNLFGKPMAQLLLGDNCTVTIAHSRTKDLADVCRRADILVAAVGRAEMVRGDWIKPGATVIDVGISRVPHPDKPGKTKLIGDVHFAEAVDVAGAITPVPGGVGPMTIACLLANTVTACCRAHGLDEPRGLTA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Sinorhizobium fredii (strain NBRC 101917 / NGR234)

Length

307 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

32.056 kDa

Sequence

MSIGCKLISGREVAESIIDQVKAHTVALSANGITPGLAVIIVGSDPASQVYVASKGRKAEECGFLSIKHELPHDVPERRLLELIDSLNADPSIHGILVQLPLPRHVDSGKVIQAISPQKDIDGFHFINVGKLGTGALETAFVPCTPAGCMILVERIHGKDLSGLSAVVVGRSNIVGKPMANLLLAANATVTIAHSRTANLEVLCRQADILIAAVGRPEMIRSDWIKPGATVIDVGINRIASRDDGGKTRLVGDVDFDGAVERAGAVTPVPGGVGPMTIAMLMANTLRAACHANDEPAPHFGSGGVLR

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Sinorhizobium fredii (strain NBRC 101917 / NGR234)

Length

307 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

32.056 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Koribacter versatilis (strain Ellin345)

Length

307 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

32.352 kDa

Sequence

MLATILDGNKISAEIKTEVAAEVAELKAKGLTPGLAVVLVGHNPASEIYVRNKVKACEMTGIYSEQHTPPDTVSTADLLQLVESLNRRNDIDGILVQLPLPKQVDSKKILLAVSPEKDVDGFHPMNVGYLSTVRPGLVPCTPAGCMEILRRSNVPVEGADAVVVGRSDIVGKPIAMLLTNANATVTICHSKTHDLPAVCRRADILVAAIGRPGMITPDFVKPGATVLDVGINKITDRAEFEKFFAGDAKREAAFAKNGSTLVGDCHPKVAEVAGAFTPVPGGVGPLTIAMLMANTVKAAKLRRGNTV

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Solibacter usitatus (strain Ellin6076)

Length

306 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

32.279 kDa

Sequence

MPRILDGNRVRDEIKGELKPRIAALAAHGRPPGLAVVLVGNNPASEIYVRNKIKTCHDLGIYSESITPPDTISTEELLAIVQGLNARAEIDGILVQLPLPPQVDTKRILMAVSPAKDVDGFHPCNVGALVANLPAPRACTPAGIMELLKRGGIPIAGQRAVVVGRSDIVGKPVAMLLLHEHATVTICHSKTPDLKSLCREADILVAAIGRAAMITGEFIKPGATVIDVGTNHVADREKAARIYRNSPEKMANFDKRGNLLIGDVDPVGVVEKAGAYTPVPGGVGPLTIAMLMVNTVASAERRAGVC

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Methylobacterium extorquens (strain CM4 / NCIMB 13688)

Length

306 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

32.417 kDa

Sequence

MIAQVIDGRAEAARLTDNVRARAHRFTDEFGRCPGLAVVLIGDDPASSVYVKAKTEKARSTGILSSSHRLPSDTTEDALLRLIDQLNRDRTVDGILVQLPLPPHIAPERVLQRILPCKDVDGFHPVNAGLLATGQPGLVPCTPLGCLRLVQSVAAELVGQNVVVVGRSTIVGRPAAQVFLNADCSVTILHKESRDVPGHCRSADILVVAAGSPGLVRRDWVKPGAVVIDVGINRIPVSSGYRLVGDVDFEGVQYVASAITPVPGGVGPMTVAALMENTVACAEALAIRAPEVMSPDNRLHFDHADV

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Thermosynechococcus elongatus (strain BP-1)

Length

306 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

32.87 kDa

Sequence

MVAHAATCLDGKSLAQSIERQLADHVRTFQAQWGRSPGLAVLRVGNDPASAVYVRAKEQACSRVGIQSFGAHLPATITEAALLAKITELNQDERVDGILLQLPLPPHLDPRPLLYAIHPDKDVDGLHPENLGRLVRDEPGLRSCTPAGVMQLLAAYGIDVVGRSAVVVGRSILVGKPLALMLLSANATVTIAHSRSRELASITRSAEILVTAMGQPRRITADMIRPGAVVIDVGINRIQRPDGKSSLWGDVDYEAARAVASYITPVPGGVGPMTVAMLLHNTVWSYCRRHNWQQPLLSLTSMPPAP

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Anaplasma phagocytophilum (strain HZ)

Length

304 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

32.881 kDa

Sequence

MGIYENNIIDGKAAAADLLGRLKVVMEGLKEEHGLFPSLVVIIVGDDPASRLYVGNKQRKAEELGINSKTIALPYETTQEELLGIIQELNEDENVHGILVQLPLPKHIDKILIINAIDPEKDVDGFHNANAGKLLTGEMDCMVPCTPQGCIYLIKKVMPVLSSKRAVVIGRSNIVGKPVALLLMYENCTVSILHSATANIEEHCRDAEIIIAAVGKARMVKSEWVSPGAVVIDVGINLITSESKNRFVGDVDFESVRDKVAAITPVPGGVGPMTIAFLLVNTVLGACRQKGIKQYKNIKSSVLQ

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Anaplasma phagocytophilum (strain HZ)

Length

304 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

32.881 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Gluconobacter oxydans (strain 621H)

Length

304 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.944 kDa

Sequence

MSMLSPEKPSEPAKIIDGKGIARALTDQVGREVAKFVEQGNTIPGLAVVLVGNDPASEVYVKNKAIQTHRVGMRSFMHMLPQSTSQDELLDLIAQLNANPKIHGILVQLPLPAQIDPVAVTNAIAPHKDVDGLGEVNAGRLSLGIDGIVPCTPLGCLMLLQSVHKDMTGMHAVVIGASNLVGKPMAQLLLKENCTVTVAHIHTRNTKELAREADILVVATGKSELVRGDWIKPGATVIDVGITRVPAENGKTRLVGDVAFDEAFPIAGHITPVPGGVGPMTIACLLHNTLQAARATQAVADASS

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Rhodospirillum centenum (strain ATCC 51521 / SW)

Length

304 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.515 kDa

Sequence

MTEARIIDGKAFAADLRGRIGAAVEHLRTAYALVPGLAVVLVGENPASQLYVKNKGEQTREAGMHSVTHRLPVDTTQEQLLRLIGQLNADPSIHGILVQLPLPPQIDPAAVLAAIDPDKDVDGFHVVNAGRLAVGLPGLVPCTPLGCLMLLKDVVGDLRGLNAVVVGRSNIVGKPMANLLLQANATVTVAHSHTVDLPEVCRGADILIAAVGRPEMIRGSWIKEGAIVIDVGINRVPARDPAAAAAGKTRVVGDVAFEEAKGIAGAITPVPGGVGPMTIACLLLNTLTAACRSKGITPPDDLMP

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Xanthomonas axonopodis pv. citri (strain 306)

Length

303 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.774 kDa

Sequence

MTASAPAASASARLLDGRRIAEELLDGLKLRVDARVAAGKARPGLAVVLVGGDPASSVYVRNKRRAAEKVGIEAFDYDLPQGTSEAQLASLIDELNADPKIHGILIQLPLPGIPDANRLIQRIDPRKDVDGFHPQNVGHLALREFGLRPCTPRGIVTLLGHTDQPVRGRNATIVGVSNHVGRPMGLELLIAGCTVTSCHKFTPPDVLEASVRNADILVVAVGRPGLIPGEWVKPGAVVIDVGINRLDDGRLVGDVGFDAAAQRAAWITPVPGGVGPMTVATLMQNTIEAADAAGIQDSGFGIR

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Xanthomonas campestris pv. vesicatoria (strain 85-10)

Length

303 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.629 kDa

Sequence

MTASAPAASASARLLDGRRIAEELLDGLKLRVDARLAAGKARPGLAVVLVGGDPASSVYVRNKRRAAEKVGIEAFDYDLPQGTSEAQLASLIDELNADPKIHGILIQLPLPGIPDANRLIQRIDPRKDVDGFHPQNVGHLALREFGLRPCTPRGIVTLLGHTDQPVRGRNATIVGVSNHVGRPMGLELLIAGCTVTSCHKFTPPDVLEASVRNADILVVAVGRPGLIPGEWVKPGAVVIDVGINRLDDGRLVGDVGFDAAAQRAAWITPVPGGVGPMTVATLMQNTIEAADAAESGDSGLGIG

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Xanthomonas oryzae pv. oryzae (strain MAFF 311018)

Length

303 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.732 kDa

Sequence

MTASAPAASTSARLLDGRRIAEELLDGLKSRVDARLAAGKARPGLAVVLVGGDPASSVYVRNKRRAAEKVGIEAFDYDLPQCTSEAELAALIDELNADPKIHGILIQLPLPGIPDANRLIQRIDPRKDVDGFHPQNVGHLALREFGLRPCTPRGIVTLLSHTDQPVRGRNATIVGVSNHVGRPMGLELLIAGCTVTSCHKFTPPDVLEASVRNADILVVAVGRPGLIPGEWVKPGAVVIDVGINRLDDGRLVGDVGFDAAAQRAAWITPVPGGVGPMTVATLMQNTIEAADAAGIEGAGVGIR

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Prochlorococcus marinus (strain NATL1A)

Length

303 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

32.956 kDa

Sequence

MPKILDGKKLAQEIELILQQAIESGLEVAKRRPGLAVLRVGDDPASGVYVNYKEKACDRIGVRSFAKHLKEDISLEELTETIKSLNEEKNVDGILLQLPLPSHLDEAALLRSIDPDKDADGLHPLNLGRLIKGEKGPRSCTPAGVMSLLERNQIKIEGKRAVVVGRSILVGKPMALMLEAANATVTIAHSRTKDLPSLTKEADLLVVAAGKPYLIGKNHVSENCVVIDVGIHRLPPDEENIKELKKTKLCGDVKIFEIEDKVAAYSPVPGGVGPMTVTMLLANTVDRWQKHCGLPLTISHLLP

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Prochlorococcus marinus (strain NATL2A)

Length

303 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

32.989 kDa

Sequence

MPKILDGKKLAQEIELILQQAIESGLEVAKRRPGLAVLRVGDDPASGVYVNYKEKACDRIGVRSFAKHLKEDISLEELTEIIKSLNEEKNVDGILLQLPLPSHLDETALLRSIDPDKDADGLHPLNLGRLIKGEKGPRSCTPAGVMSLLERNQIKIEGKRAVVVGRSILVGKPMALMLEAANATVTIAHSKTKDLPSLTKEADLLVVAAGKPYLIGENHVSENCVVIDVGIHRLPPDEENMKELKKTKLCGDVKIFEIEDKVAAYSPVPGGVGPMTVTMLLANTVDRWQKHCGLPLTISHLLP

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Desulfococcus oleovorans (strain DSM 6200 / Hxd3)

Length

303 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

32.357 kDa

Sequence

MSAKLIKGTEIREEILKEIEAEVKEIKEKHGKVPGLVTILVGESPASISYVTLKIQTAHRVGFKEVQDSQPVDISEADLLALIDKYNKDDSIHGILVQLPLPKHIDEKKVLNAIDPDKDVDGFHPVNVGRLMIGGSEVKFPPCTPAGIQEMIVRAGVETSGAEVVVVGRSNIVGKPIANMMLQKGPGANATVTVVHTRTKNMDEHCKRADILIVAAGVPGLVKPEWIKPGACVIDVGVNRVGEKPSAKDPNKMVAILSGDVDFDAAKEIAGSITPVPGGVGPMTITMLMLNTLKSLKFKLGLI

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230)

Length

303 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.535 kDa

Sequence

MTAKVLDGKATAAAIKEELRGRVAALAERGRTPGLGTLLVGEDAGSQKYVAGKHRDCAEVGIESIQRELPADATEEQILDVVRELNEDPACTGYIVQLPLPKHVDTQKVLEAIDPDKDADGLHPMNLGRLVASVGGELDSPLPCTPAGCVELLRHHGVELAGKHVLVIGRGVTIGRPAGLVLTRREVNATVTLAHTGTTNLDELLASADVVIAAAGSAHMVTPEQVKEGVIVLDVGVSRVTGEDGKSRVLGDVDPAVKEKAAWMAPNPGGVGPMTRVMLLANVVEAAERAADGENWAGERAGA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Xanthomonas oryzae pv. oryzae (strain PXO99A)

Length

303 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.732 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Xanthomonas oryzae pv. oryzae (strain KACC10331 / KXO85)

Length

303 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.732 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Arthrobacter sp. (strain FB24)

Length

302 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.273 kDa

Sequence

MAQAAKILDGKAAAAAIKSELAERVAKLKARGVTPGIATVLVGADPASQLYVSMKHKQSVEIGMNSIQRELPADATQAQVEALIDELNADPACHGYIVQLPLPKHLDTDAILERIDPAKDADGLHPTNLGRLVLNVSGEITSPLPCTPRGVIELLERNGYSLSGKHVVVVGRGVTIGRTIGLLLTRRSVNATVTLTHTGTENLSQLLRQADVIVGAAGAKHIVKAADVKPGAALLDVGVTRETDPETGKSKVHGDIDPAAAEVAGWISPNPGGVGPMTVALLMTNVVEAAERKLAAESAGTA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Arthrobacter sp. (strain FB24)

Length

302 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.273 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Prochlorococcus marinus (strain MIT 9303)

Length

302 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.453 kDa

Sequence

MALRLDGKQLAAELEQRLQAEIAAGLVQAGRPPGLAVVRIGDDPASGVYVANKQKACGRIGMASYLSHLPAKVPAAEVLATIQSLNLDERVDGILLQLPLPKGLDEGPLLAAIDPEKDADGLHTLNLGRLLKGEPGPRSCTPGGVMALLARHQIPLAGKRAVVIGRSILVGQPMALMLQAANATVSVAHSHTDDLASLTQQADVLVVAAGRARMIGSEHVKPGAVVVDVGIHRLPADPELGPQVKARLCGDVRAQEVEPLASALTPVPGGVGPMTVTMLLVNTVARWQQHCGLPFGLRDLLV

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Prochlorococcus marinus (strain MIT 9211)

Length

302 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

32.534 kDa

Sequence

MAHKLDGKQLAGEIEQRLSHEITLCLKKGVRPPGLAVIRVGDDPASQVYVSNKEKACRRAGIKSFGCHLDANSSFREIEEQIIKLNSNQEVDGILLQLPLPIGLDAGRLLKVIDPRKDADGLHTLNLGRLLKDEIGPRSCTPAGVMALLAANQIEIKGKNTVVIGRSILVGKPMALMLQAANATVTLVHSHTRDLIGFTKQAEILVVAAGKPQLIGLEHVKEKSVVVDVGIHRVFKDQNLGDAGGYKLCGDVRREEVDDFVSAITPVPGGVGPMTVAMLLVNTVNSWQQHCDLSLSLDDLLP

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Prochlorococcus marinus (strain SARG / CCMP1375 / SS120)

Length

302 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

32.579 kDa

Sequence

MTNILDGKKLAKELELRLHEDITEFSPEVGRPPGLAVIRVGDDPASGIYVSNKEKACNRIGLDSFLYHLGTNTSEQEILEVIKALNNDQKVDGILLQLPLPKGLDAEPLLKAIDPEKDVDGLHTLNLGRLLKGEKGPRSCTPAGIMVLLRRNNISLVGKKVVVIGRSILVGKPMALMLQAANATVTVAHSKTINLPEITNQAEVLIVAAGIPQLIGLEHVRSNAVVVDVGIHRIPMEPLKLTGSNYKLCGDVRAEEIYSKIKAITPVPGGVGPMTVAMLMVNTVNRWQYHCGLSSTLSDLLP

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Prochlorococcus marinus (strain MIT 9313)

Length

302 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.606 kDa

Sequence

MALRLDGKQLAAELEQRLQAEIAAGLVQAGRPPGLAVLRIGDDPASGVYVANKQKACGRIGVASHLTHLPETVSVSKVLATIQALNIDERVDGILLQLPLPKGLDEGPLLAAIDPEKDADGLHTLNLGRLLKGEPGPRSCTPAGVMALLARHQISLERKRAVVIGRSILVGQPMALMLQAANATVSVAHSHTGDLASLTQQADVLVVAAGRARMIGAEHVKPGAVVVDVGIHRLPLDPELGTQAKARLCGDVRTQEVEPLASALTPVPGGVGPMTVTMLLVNTVARWQQHCGLPFGLRDLLV

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Desulfatibacillum aliphaticivorans

Length

302 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

32.158 kDa

Sequence

MSAKLIKGTDIREEILEEVTKEVAELKEKTGKVPGLVTILVGENPASVSYVTLKIKTAHRVGFTEIQDNQSPDISEEDLLALIDKYNNDDSINGILVQLPLPKHIDDKKILNAIDPDKDVDGFHPVNVGRLMIGGDEVKFAPCTPAGIQEMIVRAGVETSGAEVVVVGRSNIVGKPIANMMVQKGPGANSTVTIVHTRTKDLAAHCQRADILIVAAGVPGLVKPEWIKKGACVIDVGVNRVGTKISEKTGKEIAVLRGDVDFDAAKEIAGSITPVPGGVGPMTITMLMVNTLKSFKFANGLM

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Sphingopyxis alaskensis (strain DSM 13593 / LMG 18877 / RB2256)

Length

302 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.722 kDa

Sequence

MTGPVPDARVIDGKAFAAGLRARIADAVPAFRAATGRAPGLAVVLVGDDPASAVYVGSKGKATVAAGMASFEHRLAATATQDEVEALLRQLNADEAVDGILLQLPLPGHLDEQAAVATIDPDKDVDGLTPVSAGRLALGIPGMVPCTPYGCLLLLQDRLGDLSGKDAIVIGRSILVGKPMGQLLLGANCTVTMAHSRTKDLPALVRRADIVVAAVGRAEMVKGDWIKPGAIVIDVGINRLPPADGAAKGRLVGDVDYAAALGVADAITPVPGGVGPMTIACLLRNTLVAAHRRAGLADPEGF

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Cyanothece sp. (strain PCC 7424)

Length

301 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

32.116 kDa

Sequence

MVSQAAKILDGKALAQKIQLSLKEEIQTLQPKIGRPPGLAVLMVGDNPASAVYVRNKEKSCTKVGMASFGRHFPGETSQSELEQVIEELNQDSRVDGILIQLPLPDHLDGIALLHQINPEKDADGLHPTNLGRLVRGEPGLRSCTPAGVMALLEEYNLEVKGKHAVVIGRSILVGKPMGLMLLEENATVTIAHSLTQNLTELTRSADILVAAAGKANLITPEMVKPGAVVIDVGINRIEDESGKARLVGDVDYEGVAEVAQYITPVPGGIGPMTVAMLLSNTVYSYRQKEAGVERQKAGGN

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Orientia tsutsugamushi (strain Boryong)

Length

301 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

32.885 kDa

Sequence

MTVIMDGKKLAELRLIETKNDLLALKDKYQITVKLVIILVGNNDASLIYVNNKVAKAKAIGMDSEIIRLFEFIEEKKLFSVIDDLNCDSTVHGIIVQLPLPPHIDALKLFARIDSRKDVDGLNPINIGYLNIGANQGLIPCTALGCIDLLQYYVTGLKGKHVVVIGKSNIVGKPLSALLLRNSCTVTICHSATVDLALHTRTADIVISAVGKANFLTDKHFSGNLAFIDVGISHIYDLQTHKRKLVGDGDFLKIKDLVKFITPVPGGVGPMTVAYLLKNTLTAAKLIYASIIDNDNEKRLC

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Orientia tsutsugamushi (strain Ikeda)

Length

301 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

32.908 kDa

Sequence

MTVIMDGKKLAELRLVETKNDLLALKDKYQITVKLVIILVGNNDASLIYVNNKVAKAKAIGMDSEIIRLFEFIEEKKLLSVIDDLNCDSTVHGIIVQLPLPPHIDALKIFARIDSRKDVDGLNPINIGYLNIGANHGLIPCTALGCIDLLQYYVTDLKGKHVVVIGKSNIVGKPLSALLLRHSCTVTICHSATVDLALHTRTADIVISAVGKANFLTNKHFSGNLAFIDVGISHIYDLQTHKRKLVGDGDFLKIKDLVKFITPVPGGVGPMTVAYLLKNTLTAAKLIYASIIDNDDEKHLC

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Borrelia afzelii (strain PKo)

Length

301 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

32.998 kDa

Sequence

MNTVFNGKDFANKYYLMLKEFLKERNLRNKITLKVVLANDEPASKLYVSIKNRVAKEIGLNVEVIKLSANSVQSDILEVIDRENKNLSTDGIIVQLPLLKGMDLNSILNGIVSSKDVDGLSFVNLGKMILGDKKGFVPCTALAVLKILRDEGIKTSGKTVVVVGRSPLVGRPISILLSSKPHDATVIACHSKSIYLDVYLRQADIIISAVGKPKLIDKSMLCGKPYVIDIGISEIETDAGKILSGDTDFDNIKDCVKFITPVKGGIGPVTVLMLMFNTIKAHLINNNMFDVLDRLEKLVEV

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Borreliella bavariensis (strain ATCC BAA-2496 / DSM 23469 / PBi)

Length

301 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

33.222 kDa

Sequence

MNTVFNGKDFANKYYLILKEFLKQHDLRDKIALKVVLANNEPASKLYVSIKNRVAKEIGLNVEVIKFSANSVQSDILEVIDRENKNLSTDGIIVQLPLLRHMDSNSILNSIVYSKDVDGLSFVNLGKMILGDKKGFIPCTALAVLKILLDEGIRTSGKTVVVVGRSPLVGKPISILLSSKPYDATVIVCHSKSIYLDVYLRQADIVISAVGKPKLIDKSMLCGEPYVIDIGISEIETDNGKILSGDTDFDNIKDCVKFITPVKGGIGPVTVLMLMFNTIKAHLINNNMFDILDRLEKLVEV

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Clavibacter michiganensis subsp. sepedonicus (strain ATCC 33113 / DSM 20744 / JCM 9667 / LMG 2889 / C-1)

Length

300 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.364 kDa

Sequence

MTAVVLDGVATASAVKSELAVRIRALREQGLVPGLGTLLVGDDPGSRSYVAGKHRDCAEVGIESIRVDLPADATEADVRTAIERLNSDPAVTGYIVQLPLPAGIDENAMLELIDPSKDADGLHPTNLGRLVLGVQGELTSPLPCTPAGIVEMLQRYDVPIAGQHVVVVGRGLTVGRPLGLLLTRKGLDATVTLTHSRTRDIEQEVRRADIVVAAVGAAHLVKPEWVKPGAAVLDVGITRVVDPETGKARLTGDVDPAVAEVAGHLSPNPRGVGPMTRAMLLANVVQAAERDARLAAELRG

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Rhodopirellula baltica (strain DSM 10527 / NCIMB 13988 / SH1)

Length

300 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.031 kDa

Sequence

MPATRLDGKKIAAEIRSEVAADVETFVSGGNPPPQLAAVLVGEDPASQVYVRNKERACAKAGIASRLDRMPAATTQAELLAKVAELNADPAVSGILVQLPLPSKANGGTGIDERAVLDAIDPIKDVDAFSPVNVGLLMQGRPRFLPCTPHGIVQLLHRTGIETSGKHVVVVGRSDIVGKPMAMMLAQKDSTCGPAVANATVTIAHSRTSNLAEICRQADILIAAVGRPEMITAEMIQPGAVVIDVGINRVGDKLVGDVAFDEAEAVASAITPVPGGVGPLTIAMLLHNTLMAAKMQAASN

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003)

Length

300 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.595 kDa

Sequence

MADRRDHRIIDGKAVQQRLLAGIRAELEAAAETHPVGRLVSISIGPSPEIEVYVRNQARAAATAGLPFEQVVWEASATQEACKRKIAALNDDPSVLGIILQRPVPAHIHVRSLQSAIHPLKDVEGMNPASIGNIVYNDIALAPCTAAAAVEMVRATGLPLPGLEVVMIGHSEIVGKPVAFLLMAEGATVTVCHHMTRSVAMHSRRADVVIVAVGKAHLIGPEMIKPGAAVIDIGINQVTDAAGKVRILGDVDTEAVREVAGWITPVPGGVGPVTVAMLMRNALTAHRRQVAAGWLEAAKA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Ruegeria sp. (strain TM1040)

Length

300 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.627 kDa

Sequence

MAAEIIDGKAFAAKVRGQVTEHVTRLKEEHGITPGLAVVLVGEDPASQVYVRSKGKQTVEVGMNSYEHKLDADTSEADLLALIDQLNKDSEVHGILVQLPLPKHLDEDLVINSIAPEKDVDGFHISNVGLLGTGQKSMVPCTPLGCLMMLRDYHGSLSGLDAVVIGRSNIVGKPMAQLLLGDSCTVTIAHSRTKDLPEVVRRADIVVAAVGRPEMVPGDWIKEGATVIDVGINRIDAPEKGEGKTRLVGDVHYESAAARAGAITPVPGGVGPMTIACLLANTVTACCRANNLSEPEGLTA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Ehrlichia canis (strain Jake)

Length

300 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

32.273 kDa

Sequence

MEANIINGKAIAEDITGTLATCINDLKLQYSLVPCLIVVLVGDDPASHLYVRNKQRKAEMLGLRSETILLPSTTSESSLIDKIHELNNDDNVHGILVQLPVPKHIDKNLIINTIDPRKDVDGFHNDNVGRLFTGQKRNCLIPCTPRGCLYLIKTVTHNLSGSDAVVIGRSNIVGKPMACLLLGENCTVTTVHSATRNLSDYCSKADILVAAVGIPNFVKSSWIKPGAIVIDVGINSVEEDGVKKFVGDVNFAEAKNVASAITPVPGGVGPMTIAFLMVNTVMAACNQSGIENFVEKYLDL

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Ehrlichia chaffeensis (strain ATCC CRL-10679 / Arkansas)

Length

300 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

32.377 kDa

Sequence

MEENIINGKVIAEDITSTLAVCINDLKVQHNVTPCLIVILVGDDPASHLYVRNKQRKAEMLGLRSETMLLPSTTSESSLIDTIRRLNNDDSVHGILVQLPVPKHIDKNLIINTIDPRKDVDGFHNENVGRLFTGQKKDCLIPCTPRGCLYLIKTVTRNLSGSDAVVIGRSNIVGKPMACLLLGENCTVTTVHSATRNLPDYCSKADVLVAAVGIPHFVKSSWIKPGAIVIDVGINAIEEGGVKKFVGDVDFSEARNIASAITPVPGGVGPMTIAFLMVNTVIAACNQAGIENFVEKYLDL

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Ehrlichia ruminantium (strain Gardel)

Length

300 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

32.475 kDa

Sequence

MEGNIVSGKAVADNITNILATCISDLKVQHNLTPCLIVVLVGDDPASQLYVRNKQRKAEMLGLRSETMLLPSTISESSLIEKIHQLNNDDSVHGILVQLPVPRHIDKNLIINTIDPKKDVDGFHNENVGRLFTGQKKNCLVPCTPQGCLYLIKTITRNLSGSDAVVIGRSNIVGKPMACLLLGENCTVTTVHSATRDLPDYCRRADILVAAVGIPRFVKYSWVKHGAIVIDVGINSIEEDGVKKFVGDVDFAEVNKIASAITPVPGGVGPMTIAFLMVNTIIAACNQSGIHGFLEKYLDL

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Ehrlichia ruminantium (strain Welgevonden)

Length

300 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

32.425 kDa

Sequence

MEGNIVSGKAVADNITNILATCISDLKAQHNLTPCLIVVLVGDDPASQLYVRNKQRKAEMLGLRSETMLLPSTISESSLIEKIHQLNNDDSVHGILVQLPVPRHIDKNLIINTIDPKKDVDGFHNENVGRLFTGQKKNCLVPCTPQGCLYLIKTITRNLSGSDAVVIGRSNIVGKPMACLLLGENCTVTTVHSATRDLPDYCRRADILVAAVGIPRFVKYSWVKHGAIVIDVGINSIEEDGVKKFVGDVDFAEVNKIASAITPVPGGVGPMTIAFLMVNTIIAACNQSGIDGFLEKYLDL

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Brucella abortus (strain S19)

Length

299 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.231 kDa

Sequence

MAQLIDGKKLAEDVVSTVKTETEKLVAATGVVPGIAVVIVGEDPASQVYVASKSRKAKECGFHSVQHDLPETASEQELLNLIEGLNNDPAIHGILVQLPLPGHIDSGRVIQTIAPEKDVDGFHFINVGKLGTGEVETAFVPCTPAGAMIMIERVHGRDLSGLNAVVIGRSNIVGKPMFNLLLAANATVTVAHSRTKDLPAIARNADILVAAVGRPQMVKGDWVKPGATVIDVGINRIPAPERGEGKTRLVGDVDFAEAEKVAGAITPVPGGVGPMTIAMLMANTLTAACRSAGMKKPVF

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Brucella abortus (strain 2308)

Length

299 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.231 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Brucella abortus biovar 1 (strain 9-941)

Length

299 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.231 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Brucella canis (strain ATCC 23365 / NCTC 10854)

Length

299 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.231 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Brucella melitensis biotype 2 (strain ATCC 23457)

Length

299 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.231 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)

Length

299 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.231 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Brucella ovis (strain ATCC 25840 / 63/290 / NCTC 10512)

Length

299 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.231 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Brucella suis (strain ATCC 23445 / NCTC 10510)

Length

299 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.231 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Brucella suis biovar 1 (strain 1330)

Length

299 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.231 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Gramella forsetii (strain KT0803)

Length

299 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

32.839 kDa

Sequence

MTILDGKKISNDIKDEIAGEVTKIKKRGEKVPHLAAIIVGKDGASMTYVNSKVKACERVGFESSLFRLPHTVSELELLDKIEELNENDDIDGFIVQLPLPPQINTQKVLNAVDPDKDVDGFHPTNFGKMALDMTSFIPATPFGILELLERYDIPTKGKHTVVIGRSYIVGRPMSILMGRSGFPGNSTVTLTHEFTKNITQVTSQADIIIIAVGIPDFLKGEMIKDDAVIIDVGITRVPDDHAERGYVIKGDVDFENVSKRASFITPVPGGVGPMTVSMLLKNTLLARERHHKRAVDAKK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Anaplasma marginale (strain St. Maries)

Length

299 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

32.282 kDa

Sequence

MREIIDGKLVARGLLDRLRVSVDRLKAEHGIVPHLVVVIVGDDPASKLYVGNKQRKAEELGLQSRTIALEHDTSQEELLRIIDELNRDAAVHGILVQLPLPRHIDKELVINAISPEKDVDGFHNANAGKLATGQLDCMIPCTPQGCIHLIKTVKQDLAGSNAVVVGRSNIVGKPVALLLLYENCTVTVLHSASRNLEEHCLRADIIVAAVGKARFIRASWIKPGAIVVDVGINLVEESGKKRFVGDVEFEGLQDVPCSVTPVPGGVGPMTIAFLLVNTVLGSCKQCGVSYEDIKSSLLQ

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Anabaena variabilis (strain ATCC 29413 / PCC 7937)

Length

299 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.583 kDa

Sequence

METKTAKILDGKTLAEKIQKELTAQIIEVQAKIGRPPGLAVLMVGDNPASAAYVRNKEKSCAKVGIASFGKHFPQETSQKELEDVIAALNQDEQVDGILVQLPLPEHLDAVKLLHQIEPDKDADGLHPVNLGRLVRGEKGLRSCTPAGVMRLLAEYEISLRGKQAVVVGRSILVGKPMALMLLEADATVTIAHSRSQDLKSITQNADILVAAAGLPGLITADMVKPGAVVVDVGINRVTDANGKSRLVGDINFASIAGVAEYITPVPGGIGPMTVALLLQNTVTSYLQTAKESGALDVK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Anaplasma marginale (strain St. Maries)

Length

299 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

32.282 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Anabaena variabilis (strain ATCC 29413 / PCC 7937)

Length

299 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.583 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Dinoroseobacter shibae (strain DSM 16493 / NCIMB 14021 / DFL 12)

Length

299 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.294 kDa

Sequence

MTAEIIDGKAFAAGVRAKVAHNVETLRDTHGITPGLAVVLVGEDPASEVYVANKHRQTVEVGMASFSHKLPAKTSEADLFALIDQLNADPAVHGILCQFPVPEHLNERAVVARIDPAKDVDGLSVVNAGLLASGERGLVSCTPLGCLMLLRDRLGDLSGLEAVVIGRSNLFGKPMGQLLLRENATVTMAHSRTRDLAQVCRRADILVAAVGRAEMVKADWVKPGATVIDVGITRQPHPDDPDKTRLLGDVDFAAVAEVAGAITPVPGGVGPMTIACLLANTVTACCRAHGLPEPDGLAV

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)

Length

299 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.408 kDa

Sequence

MQTSSEPAASETAALLGKPLADRVMRGVRADLKAWAQLDPPFEPQLVSVLASDDEASQVYVQSKAKRAKKLGVAFRVVDLGAAATQEALEQTLRELSADPAVHGIVLELPLAAGLDADAALLHIAARKDIEGLSPANLALIAAGREPEALLPPTPRSVRFLLRHALGDDLRGLRVAVIGPGRTVGRPLLFMLNNKGATVTLCNEHTRDLAAVLAAQDAVVVAVGKAGLLRPEQVQPEHVVIDAGINVQESGDMVGDALPELPVRAQTPVPGGVGPLTSALMYQNLVRGVKLQRGEPVDD

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)

Length

299 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.551 kDa

Sequence

METKTAKILDGKTLAEKIQKELTAQIIDAQAKIGRPPGLAVLMVGDNPASAAYVRNKEKSCAKVGIASFGKHFPQETTQTELEDVIAALNQDEQVDGILVQLPLPEHLDAVKLLHQIEPDKDADGLHPVNLGRLVRGEKGLRSCTPAGVMRLLAEYEISLRGKQAVVVGRSILVGKPMALMLLEADATVTIAHSRSQDLKSITQNADILIAAAGLPGLITADMVKPGAVVVDVGINRVSDAHGKSRLVGDINFASIAGVAEYITPVPGGIGPMTVALLLQNTVTSYLQTAKESGALDVK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Ochrobactrum anthropi (strain ATCC 49188 / DSM 6882 / JCM 21032 / NBRC 15819 / NCTC 12168)

Length

299 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.36 kDa

Sequence

MAQLIDGKKLAEDVVSTVKTETEKLVAATGIVPGIAVVIVGEDPASQVYVASKSKKAKECGFHSVQHDLPETASEQELLDLIESLNNDPAIHGILVQLPLPKHIDSGRVIQTISPDKDVDGFHFINVGKLGTGEVETAFVPCTPAGAMIMIERIHGRDLSGLNAVVIGRSNIVGKPMFNLLLAANATVTVAHSRTKDLPAIARTADILVAAVGRPQMVKGDWVKPGATVIDVGINRIPAPERGEGRTRLVGDVDFVEAEKVAGAITPVPGGVGPMTIAMLMANTLTAACRTAGVKKPVF

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Agrobacterium fabrum (strain C58 / ATCC 33970)

Length

299 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.627 kDa

Sequence

MAVVIDGKAKAASVTEAVRKSAEALEAEKGVKPGLAVVIVGNDPASHAYVNSKSKMAKQCGFNSIQHTLPEETTQAALLKLVGELNTDASIHGILVQLPLPKHFNSDEIIQSILPEKDVDGLSVLNAGKLATGDLATGLISCTPAGAMLLVRGIHGDDLSGLNAVVIGRSNLFGKPMGQLLLNANATVTMAHSRTKDLVTVCKTADILVAAVGRAAMVKGDWVKPGATVIDVGINRIAAPEKGEGKSKLVGDVAFDEASAVAAAITPVPGGVGPMTIAMLMANTVIAAHRALGKTAPKF

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Rhizobium leguminosarum bv. viciae (strain 3841)

Length

299 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.702 kDa

Sequence

MTTVIDGKNVAASVIQTVKSATAALEKSSGVTTGLAVVIVGDDPASHAYVGSKGRMAKECGFKSVQHTLPADTKQEDLAALVAALNADPSIHGILVQLPLPKPLDSEAIIQSILPEKDVDGLSVVNAGKLATGDLKTGLVSCTPAGAMVFVRRTHGEDLSGLNAVVIGRSNLFGKPMAQLLLNANATVTIAHSRTKNLAEVCRNADILVAAVGRPEMVRADWVKPGATVIDVGINRVAAPETGEGKTRLVGDVAFEEVSAVASTITPVPGGVGPMTIAMLMANTVIAAHRTAGQTPPQF

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Rhizobium leguminosarum bv. trifolii

Length

299 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.758 kDa

Sequence

MTTVIDGKNVAASVIQTVKSATAALEKSSGVTTGLAVVIVGDDPASHAYVGSKGRMAKECGFKSVQHTLPADTKQEDLAALVAALNADPSIHGILVQLPLPKPLDSEAIIQSILPEKDVDGLSVVNAGKLATGDLKTGLVSCTPAGAMVFVRRTHGEDLSGLNAVVIGRSNLFGKPMAQLLLNANATVTIAHSRTKNLAEVCRNADILVAAVGRPEMVRADWVKPGATVIDVGINRVAAPERGEGKTRLVGDVAFEEVSAVASTITPVPGGVGPMTIAMLMANTVIAAHRTAGQTPPQF

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Bartonella bacilliformis (strain ATCC 35685 / NCTC 12138 / KC583)

Length

299 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

32.028 kDa

Sequence

MDNIIDGKKLAENVIAKVKNETEKLKNSHNIQPGIAVIIVGDDPASQVYVASKSKKAEECGFFSMKHVLPKEVEESELLQLIEILNSDPKIHGILVQLPLPAHINTDRATQAIAVEKDVDGFHYINIGKLAANAIKDAIIPCTPAGAMMMIEQQCGQDLSGLNAVIVGRSNIVGKPMAALLTAANATVTLAHSRTRDLDEICRRADILIAAVGRPQMIKKHWVKKGAIVIDVGINRIAAPEKGPGKTRLVGDVDFEEVKGKTLAITPVPGGVGPMTIAMLMVNTLKAAARSLKLPVPKF

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Bartonella henselae (strain ATCC 49882 / DSM 28221 / Houston 1)

Length

299 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

32.25 kDa

Sequence

MNNIIDGKKLAEKIIMKVKAETTKLRNNYKIQPGIAVIIVGNDPASQVYVTSKSKKAEECGFFSIKHMISKETQEKELLHLIATLNSDPQIHGILVQLPLPDHINTNRITQAIAFQKDVDGFHYINIGKLAANALEDAIIPCTPAGAMMMIEQQCGQDLSGLDAVVVGRSNIVGKPMAALLTAANATVTIAHSRTRDLDDVCRSADILVTAIGRPQMIKKDWVKNGAIIIDVGINRIAAPEKGVGKTRLVGDVDFEEIKEKAAAITPVPGGVGPMTIAMLMVNTLKAAARLHNLPIPKF

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Bartonella quintana (strain Toulouse)

Length

299 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.986 kDa

Sequence

MNNIIDGKKLAEEIIVKVKAETIKLRNNYKIQPGIAVIIVGDDPASHVYVTSKSKKAEECGFFSIKHMLSKETSEKELLQLIATLNSDPKIHGILVQLPLPAHINTNCVTQAIAFQKDVDGFHYINIGKLSCNTLEDAIIPCTPAGAMIMIEQQCGRDLSGLDAVVVGRSNIVGKPMAALLTAANATVTIAHSRTRDLDDVCRSADILVAAVGRPQIIKKDWVKNGAIVIDVGINRIAAPEKGIGKTRLVGDVDFEAIKGKTAAITPVPGGVGPMTIAMLMVNTLNAAARLYNLPVLKL

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Bartonella tribocorum (strain CIP 105476 / IBS 506)

Length

299 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

32.097 kDa

Sequence

MNNIIDGKKLAEEIIVKVKAETIKLRNNYNIQPGIAVIIVGDDPASQVYVASKNKKAEECGFLSIKHVVSKETQEKELLQLIATLNSDPKIHGILVQLPLPAHINTNRITQAVAFQKDVDGFHYVNVGKLAANALEDAIIPCTPAGAMMMIEQHCGRDLSGLDAVVVGRSNIVGKPMAALLTAANATVTIAHSRTRDLDDVCRSADILVAAVGRPQMIKKDWIKKDAIVIDVGINRIPAPEKGVGKTHLIGDVDFENVKEKAAAITPVPGGVGPMTIAMLMVNTLKAAARLHNLPIPKF

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Psychrobacter cryohalolentis (strain K5)

Length

298 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.392 kDa

Sequence

MSIASITSTAQGSATVLDGKALAKQIEQQLRTRVDAIKAKTGRTPSLATILVGDDPASATYVRMKGNACKRVGMDSIRVEMPSVTTTAELMAKIYELNSSPDVHGILLQHPVPAHIDERACFEKIDLAKDVDGVTCLGFGRMAMQQSAYGSCTPQGIMHLLEQHNIELAGLEAVVVGRSAILGKPMAMMLLNANCTVTICHSRTQDLESHIKRADIIVGAVGVPELIKADWIKAGAVVIDAGFHPTDNGGVGDIELQGVENIASAYTPVPGGVGPMTINTLIRQTVDAAEKAAGLDNS

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Amoebophilus asiaticus (strain 5a2)

Length

298 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

32.19 kDa

Sequence

MAVILDGKQVAHFLRQSLAEQVQTLAKEGKPIPHLAIVLVGDDPASHTYVYNKVKACQEVGFQTTFIQEASHVQESTLLYLIHKLNEDTSIHGIIIQLPLPKHINAIKIIQAITPSKDVDGLHTFNYGRMACNLPTHIPATPLGILLLLEHYQIETAGKHCVIIGRGPTVGAPLSILMSRNAYPGNATVTLCHSYTQQLTNFTRQADILVVAVGKPGLITADMIKPSTTVIDVGITRIPDTTKKRGYRLKGDVAFEEVATLCNAITPVPGGVGPMTIAALLTNTLRAATNQVYNTPTS

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Amoebophilus asiaticus (strain 5a2)

Length

298 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

32.19 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Neorickettsia sennetsu (strain ATCC VR-367 / Miyayama)

Length

298 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

32.304 kDa

Sequence

MTQLIDGFRIAAGICESIATSVAHLRKNNGLVPSLRVIIVGENPASQVYVRSKQKKAESLGIDAETIALPKDTSEVELIRLVNSLNDDTSINAILVQLPLPPHINPTRIIESIDSKKDVDCFHPENVGRLALSKDALLKPCTPAGSLYLIKSALGDNLSGMDAVVIGRSNIVGKPMAMLLLHENCTITLTHSKTRNIQEKTRQADIVISAVGIPHFVKKDFIKPGATVIDVGMNKVDGKLVGDVDFEDVLQKVKFITPVPRGVGPMTIAFLMLNTVITTCLQNKLEHQEVIGTVIQKL

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Prochlorococcus marinus (strain MIT 9301)

Length

298 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

32.767 kDa

Sequence

MSLKLDGKKLSLEIEERLNEYISSNKEIAKRAPGLAVIRIGEDPASGVYVNNKEKACSRVGIKSFIFHLKDNIEQKEVEQLINKLNLDKNIDGMLLQLPIPKKFDEQKLISHINPSKDVDGLNEINIGKLVKNEPAMRSCTPAGIINLLRSQNIKIEGKKIVVVGRSLLVGKPLSLMLLNLNGTVTMTHSKTLNLNKVCREADILIAAAGKPNLIDSSFVKEGAIIIDVGIHRLKSSNKNQTRLCGDVLLEDVISKVFAYTPVPGGVGPMTVTMLLVNTIFSWQKQFGLSSNLNDLLP

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Prochlorococcus marinus (strain MIT 9215)

Length

298 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

32.56 kDa

Sequence

MSLKLDGKKLSLEIEERLNNYISSNKKIAKRAPGLAVIRIGEDPASGVYVNNKEKACSRIGIKSFIFHLKDSVEQKEVEQLIIKLNSDKDIDGILLQLPIPKKFDEQKLISSINPGKDVDGLNEINIGKLVKNEPAMRSCTPAGIINLLRSQNITIEGKKIVVIGRSLLVGKPLSLMLLNLNGTVTMTHSKTLNLNKVCREADILIAAAGKPNLVDSTFVKEGAVIIDVGIHRLKSSNKNQTRLCGDVLLEDVISKVFAYTPVPGGVGPMTVTMLLVNTIFSWQKQFGLSSTLNDLLP

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Prochlorococcus marinus (strain MIT 9515)

Length

298 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

32.708 kDa

Sequence

MSLKLDGKKLSLEIEEKLKKDIESNINSTKRPPGLAVIRIGEDPASGVYVKNKERACARVGIKSFIFHLKDTIDQKEVEQLINKLNLDNDIDGMLLQLPIPDKFDEQRLISLINPDKDVDGLNEKNIGKLVKNEPGMRSCTPAGIVNLLRSQNITIEGKKIVVVGRSLLVGKPLSLMLLNLNGTVTITHSKTINLKKICKEADILIAAAGKPNLINSSYVKDGAVIIDVGIHRLTSSDKSQTKLCGDVLLEDVIPKVYAYTPVPGGVGPMTVTMLLVNTIFSWQKQFVLLSRLSDLLP

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Prochlorococcus marinus (strain MIT 9312)

Length

298 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

32.823 kDa

Sequence

MSLKLDGKKLSLEIEERLNDYIFINKKIAKRAPGLAVIRIGEDPASGVYVNNKEKACSRVGIKSFIFHLKDNVEQKEVEQLINKLNFDKNIDGMLLQLPIPKKFDEQRLISYINPSKDVDGLNEINIGKLVKNEPAMRSCTPAGIINLLRSQNITIEGKKIVVIGRSLLVGKPLSLMLLNLNGTVTMTHSKTLDLNKVCKEADILIAAAGKPNLIDSSFVKEGAVIIDVGIHRLKSSDKNKTRLCGDVLLEDVIPKVLAYTPVPGGVGPMTVTMLLVNTIFSWQKQFGLSSTLNDLLP

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Prochlorococcus marinus subsp. pastoris (strain CCMP1986 / NIES-2087 / MED4)

Length

298 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

32.785 kDa

Sequence

MSLKLDGKKLSLEIEERLRNYILTNKTIAKRNPGLAVIRIGEDPASGVYVGNKEKACSRVGIKSYIFHLKDTVEQKEVEQLLNKLNLDNNIDGMLLQLPISKKFDEQRLISFINPEKDVDGLNEQNIGKLVKNEQAMRSCTPAGIVNLLKSQNIKIEGKKIVVIGRSLLVGKPLSLMMLNLNATVTITHSKTINLNKICKEADILIAAAGKPNLINSSFVKEGAVIIDVGIHRLTSSDKSKTRLCGDVLLEDVIPKVFAYTPVPGGVGPMTVTMLLVNTIFSWQKQFGLSSTLNDLLP

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Prochlorococcus marinus (strain AS9601)

Length

298 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

32.686 kDa

Sequence

MSLKLDGKKLSLEIEKRLNDYISNNKIIAKRVPGLAVIRIGEDPASGVYVNNKEKACSRIGIKSFIFHLDESVEQKEVEQLIIKLNSDKDIDGMLLQLPIPKKFDEQKLISHINPSKDVDGLNEINIGKLVKNEPGMRSCTPAGIINLLRSQNITIEGKKIVVIGRSLLVGKPLSLMLLNLNGTVTMTHSKTLNLNKVCREADILIAAAGKPNLIDSSFVKEGAVIIDVGIHRLKSSDKNQTRLCGDVLLEDVISKVFAYTPVPGGVGPMTVTMLLVNTIFSWQKQFGLSSTLNDLLP

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / CIP 104284 / JCM 5825 / NCTC 11152)

Length

298 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

32.455 kDa

Sequence

MEEQHYQLLDGKAVSAQMKKEMAEEVAQIKAAGGKIPHLAAILVGHDGGSETYVASKVKTCQEIGFKSTLIRFEEDVTEEELLRKVDELNNDPDVDGFIVQLPLPKHISEQKVIEAIDYRKDVDGFHPINVGRMSIGLPCFVSATPAGILELLKRYHIETQGKHCVVLGRSNIVGKPMATLMMQKSYPGDCTVTVCHSRSKNLKEMCLSADIIIVALGVPEFLKGDMVKEGAVIVDVGTTRMPSSITKSGFKLTGDVLFNEVAPKCSYITPVPGGVGPMTIISLMRNTLLAGKKAIYK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Parvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966)

Length

298 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.056 kDa

Sequence

MTATIIDGKIIATELRARVAVEVARLKKDHSLTPGLAVVLVGNDPASEVYVRNKGIATTEAGMNSFEFKLPAETSEADVLAKVRELNADPAVHGFLVQFPVPNHISQQAVIDAIDPVKDADGLHPLNAGRLASGLPAMVPATPEGCVIMAKRAGGDLSGKHAVIIGRSNLVGKPVAQLLLKENCTVTIAHSRSRDLPSIARQADILVAAVGRPGMVRGDWVKPGAVVIDVGINRVPAPEKGEGKTRLVGDVLFDEAAEVAGAITPVPGGVGLMTVACLLRNTVIAACRQNGIALPQDF

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Caulobacter sp. (strain K31)

Length

298 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.781 kDa

Sequence

MSQARIIDGKAFAARLREQVAAEVAVLKAEHGLTPGLAVVLVGEDPASQVYVRNKGEQTLAAGMHSETHRLPANASQAELLSLVDRLNDDPAIHGVLVQFPVPDHLSQAAIVAAISPDKDVDGLTVVNAGRLASGLPALTSCTPAGCMVLLRDVVGDLTGKRAVVIGRSNLMGKPMAQLLLAADCTVTIAHSRSRDLPAICREADILVAAVGRAEMVRGDWIKPGATVIDVGISRFPSRDPVAAAAGKTRLVGDVAFDEAKEVAGAITPVPGGVGPMTIAMLLANTVSAAKRLNGIAE

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Chelativorans sp. (strain BNC1)

Length

298 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.669 kDa

Sequence

MVQIIDGKAVAATILEKVTRETQDLKANGVTPGLAVVIVGEDPASQVYVASKGRKATECGFHSVQHSLPENTSEEELVSLVEALNRDPAIHGILVQLPLPKQIDSERIIHTIAPEKDVDGFHILNVGMLGTGAVTKALVPCTPAGAMLLIEGVRGKDLSGLSAVVIGRSNIVGKPMANLLLAANATVTIAHSRTADLPAACRGADILVAAVGRPEMVKGDWIKPGATVIDVGVSRIPAPEKGEGKMKLVGDVAYAEAEKVAGAITPVPGGVGPMTIAMLMANTLAAASKASGRDLPAF

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Erythrobacter litoralis (strain HTCC2594)

Length

298 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.371 kDa

Sequence

MTAEIIDGKAFAARLRERVGALAEKFEAAAGRKPGLAVVLVGEDPASEVYVRNKGKATLAANMESFEYKLPADTTAQDLLALVKKLNGDPAVDGILVQLPLPDHLDEQSIIAAISPDKDVDGFHVINAGRLSVGQRGFVPCTPLGCMMLLADRLGDLSGLEAVVIGRSNIVGKPMAQLLLDANATVTIAHSRTRNLPEVVKRADIVVAAVGRAEMVKPEWLKDGATVIDVGINRLPPEPGKERGRLVGDVDFGRASEVAAAITPVPGGVGPMTIAVLLRNTLVAAHRNEGIDLPEDAI

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)

Length

297 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.807 kDa

Sequence

MTEIIDGDAVAAQLRADLTGAVETLETAGVTPRLATVLMNDKQASETYVSMKQQDCEEVGIAAEDVRIDPEASADTLFDTVAELNAREDVHGILVQDPTPDHVPDERVLSAVDPAKDVDGFHPENVGKLVGGTPRFKPCTPHGVQKLLAHQGVDPDGAEVVVVGRSNIVGKPLANLLAQKAAGGNATVTICHSHTDDLAAHTRRADVVVAACGVPELIDGDMLSGDPVVIDVGINRVDADTEKGYELVGDVDYDSAEAAASAITPVPGGVGPMTRAMLLYNTLAAASEQTGVAVALP

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / NBRC 14720 / NCIMB 2260 / Gabara)

Length

297 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.496 kDa

Sequence

MTEVIDGNAVASDIRDDLTDAIATLADAGARPGLATVLMGDDPASETYVNMKQRDCEEVGIESYHVDVDGDAPPETLYDEIAALNQNDDVHGYIVQAPVPDHVDYREVIRRVDPQKDVDGFHPENVGRLVAGDARFRPCTPHGVQKLLEAADIDTEGKDVTIVGRSDIVGKPLANLLIQKADDGNATVTVCHSRTENLAAKTRRADIVVAAAGAPELVDGSMIGEGSVVIDVGVNRVDADNEKGYELVGDVEYESATQNASAITPVPGGVGPMTRAMLLYNTVKAASLQEDIDVALP

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Novosphingobium aromaticivorans (strain ATCC 700278 / DSM 12444 / CIP 105152 / NBRC 16084 / F199)

Length

297 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.785 kDa

Sequence

MTAAVIDGKAFAATLRGRVGDLATAFEARAGRKAGLAVVLVGEDPASQVYVRSKGKSTLEAGMASFEHKLPADTAEADLLAVVEQLNADPAVDGILVQLPLPRHMDEQKVIAAINPDKDVDGFHVINAGRLAVGQPGFVPCTPLGCLMLLKDRLGDLSGLDAVVIGRSNIVGKPMAQLLIAESCTVTVAHSRTKNLPEVVRRADIVVAAVGRPEMVKGDWIKPGATVIDVGINRVPGKEEGKTRLVGDVDYASAAEVASAITPVPGGVGPMTIAVLLRNALVAAYRNAGIDLSADAI

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)

Length

297 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.443 kDa

Sequence

MTEAIIIDGKEFSSNLRNKIAEDVKAFKKERNVVPGLAVVLVGEDPASRIYVRKKEEMTTAVGMNSLSYRLDANASQQELLDLIETLNHDPAVHGILVQLPLPKHIDTPTILEAIDPDKDVDGFHVVNAGRLAIGTPSLVPCTPAGCMMLLEHSLGSLKGKNALVIGRSTIVGRPMAQLLLAADCTVTVAHRHTKNLEELCRQADIVVAAVGIPHFVKASWLKPGAVVIDVGINRVPAEDEAAKAAGKTRIVGDVDFVEAAKVASAITPVPGGVGPMTIACLLNNTVQAARNLTSAS

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Caulobacter vibrioides (strain ATCC 19089 / CB15)

Length

297 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.685 kDa

Sequence

MAQAKLIDGKAFAADLRAKIAEEVAALKAEHGVTPGLAVVLVGEDPASQVYVRNKGEQTTAAGMYSETHRLPETTTQDELLAVVAKLNADPKIHGVLVQFPVPPHISQMDVVAALSPDKDVDGLTVTNAGRLASGLPALAPCTPTGCMMLIRDAIGDLKGKTAVVIGRSNLMGKPMAQMLLAADCTVTIAHSRSQDLPSIVRQADIVVAAVGRAEMVKADWVKPGAVVIDVGITRFPARDPEAAAAGKTRLVGDVAFDEVREVAGAITPVPGGVGPMTIACLLANTLTAAKRLSGIA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Caulobacter vibrioides (strain NA1000 / CB15N)

Length

297 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.685 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Lawsonia intracellularis (strain PHE/MN1-00)

Length

297 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.901 kDa

Sequence

MAADIINGMEIRESILEELRGEVANLKRDYNVVPGLVTILVGNHPASLSYVTLKIKTAIELGFHEIQDNQSETITEEELIGIIKKYNEDPLIHGILVQLPLPSHINEGKVLHAIDPNKDVDGFHPMNLGRLVIGGNAITFLPCTPAGIQELLIRSSVETLGAEVVVIGRSNIVGRPISIMLTQKGVGGDATVTLVHTKSKNIVRHCQQADIVIAAVGVPNFVKAEWIKPGATVIDVGVNRIGFNEDTGKPILSGDVDFVNVSQVAGKITPVPGGVGPMTIAMLMRNTVRSAFFHLSL

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Bifidobacterium animalis subsp. lactis (strain AD011)

Length

297 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.127 kDa

Sequence

MAIVLDGKKVAGQIKADLASRVAGLARMGMVPGLGTVLVGDDPGSMKYVEGKHRDCEEVGIASIRRQLPATATTEDVLAVVRDLNEDPACTGYIIQLPLPAHIDSNAIIGAIDPTKDADGMHPYNLGELVLHVRGDITTPLPCTPRGVLALLDAYGIELAGRNVCVLGRGITIGRTIGLMLTRSGVNATVTLCHTGTRNIEEHIRRADVVIAAVGVAGFVQVEHVKPGAVLIDVGVSRVFDEQAGRMRIVGDVDSEAHAVAGAYSPNPGGVGPMTRAMLLANVVEQAERMAGIREDS

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Phenylobacterium zucineum (strain HLK1)

Length

297 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.371 kDa

Sequence

MTAKIIDGKVLAERLRGQVADEVARLRADYRLQPGLAVVLVGEDPASQVYVRSKGEHSLAVGMHSVTHRLPADTRQDELLRLVAELNADPLIHGILVQLPLPKHLDEKAVIAAISPDKDVDGLHVVNAGRLASGLPALVPCTPLGCLIMLRETLGDLTGKRAVVVGRSLLVGKPVAQLLLQADCTVTIAHSRTVDLPAVCREADILVAAVGRPRMIRGDWIKPGATVIDVGINRVPFDDPEKAAQGKTKLVGDVHYKEALQVAGAVTPVPGGVGLMTVACLLQNTVTAAKRLAGIEG

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Porphyromonas gingivalis (strain ATCC BAA-308 / W83)

Length

296 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.933 kDa

Sequence

METTYKLLDGKKISGEIKQEIAAVVNELLEKGGRRPHLAGVLVGHDGGSETYMASKVKACEEVGFTSSLIRYEDDVTEEELLACVHRLNQDPTVDGFIVQLPLPKHIDEQKIIEAVDPRKDVDGFHPINVGRLSIGLPGFVSATPKGIVELLRRYNIPTRGKHCVVLGRSNIVGKPVSQLLLQKGEPGDCTITICHSRTPNIKEVCLTADIIIAALGQPEFLTADMVKPGAVVVDVGTTLVPDSTRKSGFRLTGDVKFDEVAPKCSYITPVPGGVGPMTIVSLMSNTLLASKGLYR

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Dehalococcoides mccartyi (strain ATCC BAA-2100 / JCM 16839 / KCTC 5957 / BAV1)

Length

296 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.33 kDa

Sequence

MSAHIINGTEIAAAIREEIRSEVIALKAKAGIVPGLATVLVGDDPASHSYVDSKIKMCQNLGIYSEHHPLPQNATIEDLLTLIAKLNADPKISGILVQVPLPAQISESLVLNAINPDKDVDGFHPVNVGRMCLGEPCFLPCTPHGVQELLIRSGIKIEGTHVVIVGRSNLVGKPLANILLQKAPGANATVTICHSGTKNLPEITRQADILVAAMGKPKFITSDMVREGAVVIDVGTTCIGYTPEGKRILSGDVDFEEVKEKAFAITPVPKGVGPMTIIMLMLNTLTAAKRAAGLIK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Dehalococcoides mccartyi (strain CBDB1)

Length

296 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.361 kDa

Sequence

MSAHIINGTEIAAAIREEIRSEVTALKTKAGIVPGLATVLVGDDPASHSYVDSKIKMCQNLGIYSEHHPLPQNATNEDLLTLIAKLNADPKISGILVQVPLPAQISESLVLNAINPDKDVDGFHPVNVGRMCLGEPCFLPCTPHGVQELLIRSGIKIEGTHVVIVGRSNLVGKPLANILLQKAPGANATVTICHSGTKNLPEITRQADILVAAMGKPKFITADMVREGAVVIDVGTTCIGYTPEGKRILSGDVDFEEVKEKAFAITPVPKGVGPMTIIMLMLNTLTAAKRAVGLIK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Desulfotalea psychrophila (strain LSv54 / DSM 12343)

Length

296 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.253 kDa

Sequence

MSAKIISGTEIRKEILGEIKDAVTEMKDKYGTVPGLVTILVGESPASMSYVSLKIKTALSLGFYEVQESLSVETTEAELLALIEKYNNDDSIHGVLVQLPLPKHINEQNIITAIDPDKDVDAFHPVNIGRLMIGGDDVKFLPCTPAGIQEMLVRSGVETAGAEVVVVGRSNIVGKPIAMMMAQKGIGANATVTIVHTGSRDLATHCRRADILIVAAGVPNLVKPEWIKPGATVIDVGVNRVGTNSETGKAILRGDVDFEAVKEIAGKITPVPGGVGPMTIAMLMKNTLASALAHSS

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIB 8255 / S1)

Length

296 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.448 kDa

Sequence

MGAHLIDGKAIAQQLRERIAQEVADLKAHRGLVPGLAVVLVGEDAASQVYVGSKEKMAVAVGMHSVVCRLAATTSEAEVLAKVEALNADPTIDGILVQLPLPAHIDEDKILLAIDPDKDVDGFHPVNVGRLSIGQSNGEHGMVPCTPKGCLMLLKGVLGDLTGKTALVIGRSNIVGKPMAQLLLSANCTVTLAHSRSRDLPDLCRRMDIVVAAVGRPEMVKGDWLKPGAVVIDVGMNRLPAAPGAEKGKLVGDVDYASAAAVAGAITPVPGGVGPMTIACLLANTLEACKARGAGA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Rhodobacter sphaeroides (strain ATCC 17029 / ATH 2.4.9)

Length

296 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.57 kDa

Sequence

MTAKRIDGKAFAAGVRARVAEEVARLKEGHGIVPGLAVVLVGEDPASQVYVGAKGKQTVEVGMASFEHRLPAETSEAELLALIDRLNHDPAVHGILVQLPLPAHLNADLVINALDPAKDVDGFHISNVGRLGTGQKSMVPCTPLGCLMMLRDHLGTLSGLNAVVVGRSNIVGKPMAQLLLGESCTVTIAHSRTRDLAAVCRGADILVAAVGRPEMITGDFVKPGATVIDVGINRIERDGKTKLVGDVDYASAAEVAGAITPVPGGVGPMTIACLLANTLTACCRANGLPEPQGLTA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)

Length

296 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.467 kDa

Sequence

MTAKRIDGKAFAAGVRARVAEEVARLKEGHGIVPGLAVVLVGEDPASQVYVGAKGKQTVEVGMASFEHRLPAGTSEAELLALIDRLNHDPAVHGILVQLPLPAHLNADLVINALDPAKDVDGFHISNVGRLGTGQKSMVPCTPLGCLMMLRDHLGALSGLNAVVVGRSNIVGKPMAQLLLGESCTVTIAHSRTRDLAAVCRGADILVAAVGRPEMITGDFVKPGATVIDVGINRIERDGKTKLVGDVDYASAAEVAGAITPVPGGVGPMTIACLLANTLTACCRANGLPEPQGLTA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Rhodobacter sphaeroides (strain ATCC 17025 / ATH 2.4.3)

Length

296 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.626 kDa

Sequence

MTAKRIDGKAFAAGVRAQVADHVARLKADHGLVPGLAVVLVGEDPASQVYVGAKGKQTVEVGMASFEHRLSAETSEAELLALIDRLNRDPLVHGILVQLPLPPHLNSDLVINALDPAKDVDGFHISNVGRLGTGQKSMVPCTPLGCLMMLRDHLGNLSGLNAVVVGRSNIVGKPMAQLLLGESCTVTIAHSRTKDLAAVCRGADILVAAVGRPEMITGEFIKPGATVIDVGINRIERDGKTKLVGDVDFASAAEVAGAITPVPGGVGPMTIACLLANTLTACCRANGLPEPQGLTA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Rhodobacter sphaeroides (strain KD131 / KCTC 12085)

Length

296 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.513 kDa

Sequence

MTAKRIDGKAFAAGVRARVAEEVARLKEGHGIVPGLAVVLVGEDPASQVYVGAKGKQTVEVGMTSFEHRLPAGTSEAELLALIDRLNHDPAVHGILVQLPLPAHLNADLVINALDPAKDVDGFHISNVGRLGTGQKSMVPCTPLGCLMMLRDHLGTLSGLNAVVVGRSNIVGKPMAQLLLGESCTVTVAHSRTRDLAAVCRGADILVAAVGRPEMITGDFVKPGATVIDVGINRIERDGKTKLVGDVDYASAAEVAGAITPVPGGVGPMTIACLLANTLTACCRANGLPEPQGLTA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Kocuria rhizophila (strain ATCC 9341 / DSM 348 / NBRC 103217 / DC2201)

Length

296 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.615 kDa

Sequence

MTAQVLDGKATAGQIKEELAQRVARLRERDVVPGLGTVLVGDDPGSRSYVAGKHRDCEQVGLASIRRELPADASQEELERVIDELNEDPRCTGYIVQLPLPEYMDTNSVLERIDPAKDADGLHPTNLGRLVLNVSEPMTSPLPCTPHGIVELLTRHGVELAGREVLVIGRGVTVGRPMGLLLTRREINATVTLAHTGTRNLPELLGRADVVVAAAGRPHMVTAEQVKPGAVLLDVGVSRVPDPETGKGRLTGDIDPAAAEVASWMSPNPGGVGPMTRAMLLVNVVESCERQVFGQP

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Blochmannia floridanus

Length

296 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

32.943 kDa

Sequence

MNTKIIDGTYIAERIKKDITQKVYADMNMGKRAPGLAMLLIGNNPISKIYIAHKKKVCKQVGFKSFLYNLPITATKTELLQLINILNNDKNIDGILIQLPLPDKLNDIKILEHIIPDKDVDGFHPYNVGRLCQRSPMLRPCTSRGIMTLLKWYNINTFVLNAVIIGASNIVGRPMLMELLLAGCTVSITHRFTQNLQVYVKNADLLIVAVGKANFLPSSWIKPGAIVIDVGINRLKNGNIVGDVHFPSAYKRAAYITPVPGGVGPMTVISLIQNTLQAYHAHVCCDSKKKIHFKKF

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Psychrobacter arcticus (strain DSM 17307 / 273-4)

Length

295 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.979 kDa

Sequence

MSIASIASTAQGSATILDGKALAKQIEQQLSTRVDAIKAKTGRTPSLATILVGDDPASATYVRMKGNACQRVGMDSIRVEMPSATTTAELMAKIDELNNNPDVHGILLQHPVPAHIDERACFEQIDLAKDVDGVTCLGFGRMAMQQSAYGSCTPQGIMHLLEHHNIELAGLEAVVVGRSAILGKPMAMMLLNANCTVTICHSRTQDLESHIKRADIVVGAVGVPELIKANWIKAGAVVIDAGFHPTDNGGVGDIELQGVENIASAYTPVPGGVGPMTINTLIRQTVDAAEKSAGL

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Wolbachia pipientis subsp. Culex pipiens (strain wPip)

Length

295 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.868 kDa

Sequence

MSIIINGKKTANDLCEELSKKIDILKKEYNVFPCLKVILVGSNPASQVYVRNKQRKAESIGISSETIVLPDSISEDELIEKVNTLNEDSSVHGILVQLPLPKHISASRIINTVSVEKDVDGFHDENVGRLVKGEKNCLIPCTPKGSLHLIKSVENNLSGKNAVIIGRSNIVGKPMFHLLLQENCTVTILHSQSRDLADYCSKADIVVAAVGKPNFVQPDWIKKGAIVIDVGINSINIGNQSKLVGDVDFEGVKEKVKAITPVPGGVGPMTIAFLMINTLVAACLQKGVDPSDFIA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Wolbachia sp. subsp. Brugia malayi (strain TRS)

Length

295 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

32.111 kDa

Sequence

MTIIIDGKKIASGLCEKLSQRIDVLKREHSIFPCLKVIFVGNNPASQVYVRNKQKKAESIGISSETIVLPDNILENELIEKINELNNDRFVNGILVQLPLPNHINASKVINTVSVEKDVDAFHRENVGKLVKGEKNCLVPCTPKGALHLIKLVETNLSGKNAVVIGRSNIVGKPMFHLLLQENCTVTILHSQSKDLAEYCSKADVVVTAVGKPNFVQEGWIKEGAIVIDVGINSVSIEGKTKLIGDVDFDRVKEKTKAITPVPGGVGPMTIAFLMINTVIAACLQKKVDASDFVS

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Nitrosomonas eutropha (strain DSM 101675 / C91)

Length

295 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.534 kDa

Sequence

MSATIISGNFIASKLREELKQRIRILSETWMQPGLAVILAGDNPASSVYVRNKARTCGELGIHSKVFNFSADTPQKIILRQIQDLNANPEIHGILVQLPLPSHIQMNEVIAAIAIEKDVDGFHPCNVGALATGHALFRPCTPFGVMKMLAEYGIPLQGQHAVVVGRSNIVGKPMALMLLEQGATVTICTSQTRELASHTRSADIIVMATGKANLLTSDMIRTGATVIDVGINRLADGQLCGDVEFSGVKEKAGYITPVPGGVGPMTITMLMNNTIEAAEHAKAKAQIEARCGSMQ

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Nitrosomonas europaea (strain ATCC 19718 / CIP 103999 / KCTC 2705 / NBRC 14298)

Length

295 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.437 kDa

Sequence

MSATIISGSLIASKFREELKQRVKILSETWMQPGLAVILAGDNPASCVYVRNKAKTCEELGIRSEIFNFPGDISQKALLQQIQDLNVNPEIHGILVQLPLPGHIRIDEVIAAIAIGKDVDGFHPCNVGALVTGHALFHPCTPFGVMKMLAEYDIPLQGQHAVIIGRSNIVGKPMALMLLEKGATVTVCTSRTRDLASHTRNADIVVMAAGKANLLTSDMIRTGATVIDVGINRLADGRLCGDVEFSGVKEKAGYITPVPGGVGPMTIVMLMNNTIEAAERAKAVALAGGWHSSVQ

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Flavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / UW101)

Length

295 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.853 kDa

Sequence

MQLLDGKKTSNDIKNEIAAEVQSIKAAGGKVPHLAAVLVGNNGASLTYVGSKVKSCQEIGFDSTLVSLPETITEDELLAKIKELNEDDNLDGYIVQLPLPKHIDEQKILLAIDPDKDVDGFHPTNFGRMALEMESFIPATPFGIMELLERYKVETAGKHTVVIGRSHIVGRPMSILMSRKGNPGDSTVTLTHSRTKDLAEFTKNADIIITALGVPEFLKADMVKEGVTVIDVGITRVEDASNAKGYVIKGDVDFEGVSKKASFITPVPGGVGPMTIAMLLKNTLLARKMRSAKNK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Prosthecochloris aestuarii (strain DSM 271 / SK 413)

Length

295 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

32.087 kDa

Sequence

MMLIDGKKVSTDLKNELKTRVEELKAKAGCVPGLTVIIVGEDPASQVYVRNKAKSCKETGMNSTVIELPAETTQEELLGKIEALNQDPDVHGILVQQPLPSHIEEYAVTMAIDPAKDVDGFHPENVGQMVLGNLDKCFISCTPFGILELLRRYDIETRGKHCVVVGRSNIVGKPMANLMLQKLRETNCTVTVCHSATQNMPELTRQADILIAAIGRANFITREMVKPGAVVIDVGINRIEDPSRKSGFRLAGDVDFDNVAEMASAITPVPGGVGPMTIAMLLKNTLQSFARSHNL

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Tropheryma whipplei (strain TW08/27)

Length

295 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.109 kDa

Sequence

MVAKVLDGLAVSAGIFERLHRACCELENNGVCPKLATVLVGNNPASRSYVLSKHRDCNNIGIQSTLIELPANTSEKELISKVEILNASSDVSGIIVQLPLPESIDQNKVIEAINPDKDADGLHPLNLGYLVTGKQGIVPCTPAGIVKLLEAHRITLEGKTIAVIGRGTTVGRPLGILLSGKGVNATVINIHSRSRNISGLSRIADVVVACAGVKHIVEPSWIKPGAVVVDVGINQSGVSSSGKMILTGDVHPLTKNIASYISPVVGGVGPMTRAMLMSNVINLSERDFRKRLYAS

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Tropheryma whipplei (strain Twist)

Length

295 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.123 kDa

Sequence

MVAKVLDGLAVSAGIFERLHRACCELENNGVCPKLATVLVGNNPASRSYVLSKHRDCKNIGIQSTLIELPANTSEKELISKVEILNASSDVSGIIVQLPLPESIDQNKVIEAINPDKDADGLHPLNLGYLVTGKQGIVPCTPAGIVKLLEAHRITLEGKTIAVIGRGTTVGRPLGILLSGKGVNATVINIHSRSRNISGLSRIADVVVACAGVKHIVEPSWIKPGAVVVDVGINQSGVSSSGKMILTGDVHPLTKNIASYISPVVGGVGPMTRAMLMSNVINLSERDFRKRLYAS

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Rhodopseudomonas palustris (strain HaA2)

Length

295 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.468 kDa

Sequence

MTATIIDGKIISAELRARVAAEVTRIKADHGITPGLAVVLVGSDPASEVYVRSKHKQTQEAGMASFEHRLPADVPQAELLALIGQLNADPAVHGILVQLPLPKGLDSNAVIDAIDPAKDVDGLNPVNAGRLASGLFALTPCTPLGCIIMAKQVHASLEGMNAIVIGRSNLVGKPLVQLLLNENATVTIAHSRSRDLPALCRQADLVFAAVGRPEMVKGDWIKPGATVIDVGINRTPSPDGGKDKLVGDVAFAEAKDIAGAITPVPGGVGLMTVACLLVNTVRAASAIHGLPKPAV

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Rhodopseudomonas palustris (strain BisA53)

Length

295 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.554 kDa

Sequence

MSARIIDGKVISAELRARVAAEVTRIKTDHGITPGLAVVLVGADPASEVYVRSKHKQTQEAGMASFEHRLPADVPQAELLALIAKLNADPTVHGILVQLPLPKGLDSNAVIDAIDPAKDVDGLNPVNAGRLASGLFALTPCTPLGCIIMAKQVHASLEGMNAIVVGRSNLVGKPLVQLLLNENATVTIAHSRSRDLPALCRQADLVFAAVGKPEMIRGDWIKPGATVIDVGINRTPSPDGGKDKLVGDVAFAEAKEVAGAITPVPGGVGLMTVACLLVNTVRAASAIHGLPKPAV

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)

Length

295 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.537 kDa

Sequence

MTARIIDGKTISAEVRARVAAEVTRLKTDHGITPGLAVVLVGNDPASEVYVRSKHKQTQEAGMASFEHRLPADVPQAELMALIAKLNADPAVHGILVQLPLPKGLDSNAVIDAIDPAKDVDGLNPTNAGRLASGLFALTPCTPLGSIIMAKTVHASLEGMNALVIGRSNLVGKPLVQLLLNENATVTIAHSRTRDLPALCRQADLVFAAVGKAEMVKGDWIKPGATVIDVGINRTPGKDGGKDKLLGDVAFAEAKEVAGAITPVPGGVGLMTVACLLVNTVRAACAIHGLPKPAV

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Rhodopseudomonas palustris (strain BisB18)

Length

295 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.455 kDa

Sequence

MTARIIDGKTISAELRGKLADEVARVVRDHGVTPGLAVVLVGSDPASEVYVRSKHKQTKEAGMASFEHKLPADVPQAELLALIGQLNADPAVHGILVQLPLPKGLDSNAVIAAVDPAKDVDGLNPVNAGRLASGLFALTPCTPLGCIVMAKQVHASLEGMNAIVIGRSNLVGKPLVQLLLNENATVTIAHSRSRDLPALCRQADLVFAAVGKPEMVRGNWIKPGATVIDVGINRTPSPDGGKDKLVGDVAFAEAKEVAGAITPVPGGVGLMTVACLLVNTLRAACAIHGLPKPAV

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Rhodopseudomonas palustris (strain BisB5)

Length

295 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.453 kDa

Sequence

MTARIIDGKIISADLRGRVAAEVTRIKAEHGITPGLAVVLVGSDPASEVYVRSKHKQTQEAGMASFEHRLPADVAQADLLALIGQLNADPAVHGILVQLPLPKGLDSNAVIDAIDPAKDVDGLNPVNAGRLASGLFALTPCTPLGCIIMAKQVHASLEGMNAIVIGRSNLVGKPLVQLLLNENATVTIAHSRSRDLPALCRQADLVFAAVGKAEMVKGDWIKPGATVIDVGINRTPSPDGGKDKLVGDVAFHEAKDVAGAITPVPGGVGLMTVACLLVNTVRAASAIHGLPKPGV

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Rhodopseudomonas palustris (strain TIE-1)

Length

295 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.537 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Rickettsia akari (strain Hartford)

Length

295 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.875 kDa

Sequence

MNNIIDGKALANEILEDLKLEIQELKSQTNASPKLAIVLVGDNPASIIYVKNKIKNAHKIGIDTLLVNLSTTIHTNDLITKINELNHDNEISGMIVQLPLPNSIDKNKILSAVSPYKDVDGFHPLNVGYLHSGIIDVSEFSQSFIPCTALGCLAVIKKYEPNLSGKHVVVIGRSNIVGKPLSALLLKEDCSVTICHSKTHNLGSIALKADIVVAAIGSPLKLTAEYFNPESIVIDVGINRISGNKIIGDVDFEHVKSKVKYITPVPGGIGPMTIAFLLKNTVKAFKDSYSTVCHL

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Xylella fastidiosa (strain 9a5c)

Length

295 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.431 kDa

Sequence

MIVSMLAATDLARILDGRRIADDLLDALKTRVDARVAAGKLPPTLAVVLVGSDPASVVYVRNKRRAAEKVGIKAYDFDLPEATTEAELAALIDRLNADPKIHGILIQLPLPGIPDAHRLIQRVDPRKDVDGFHPQNVGHLALREFGLRPCTPRGIVTLLGHTDRPVRGRNATIVGVSNHVGRPMGLELLMAGCTVTSCHKFTPPQMLEAAVRQADILIVAVGRPGVIPGEWVKPGAVVIDVGINRLDDGRLVGDVGFESAVKRASWITPVPGGVGPMTVATLMQNTLEAAEAADC

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Hyphomonas neptunium (strain ATCC 15444)

Length

295 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.436 kDa

Sequence

MTATRLDGNAVAADVRSAVAAAVSALPGQPCLAVVLVGEDPASEVYVRNKVKMTEAAGMVSIHHRLPADTGQAEVERLIESLNADPEVDGILLQLPLPKGLDADAAIEKINPDKDVDGLTEVSAGRLSLGKPGLRPCTPVGSVILAKRALGPDLSGKNVVVIGRSILVGKPAALLFLAENCTVTIAHSKTADLANVCRSADILVPAVGRPEMVRGDWVKPGAAVIDVGINRIPAPEKGEGKTRLVGDAHYESCAEVAGFITPVPGGVGPMTIACLLRNTVLAACARRGWTVPEGL

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Kineococcus radiotolerans (strain ATCC BAA-149 / DSM 14245 / SRS30216)

Length

295 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.448 kDa

Sequence

MSATVLDGKAAAAAVKADLKERVAALRERGVVPGLGTVLVGDDPGSASYVRGKHRDCAEVGIASIQVELPATATQGEIESEIAQLNANPDCTGFIVQLPLPAGIDANRILEQVDPDKDADGLHPTNLGRLVLRVREEITSPLPCTPRGVIDLLLRHDVPLDGAEVVVVGRGVTVGRPIGLLLTRRHPNATVTLCHTGTRDLESHLRRADVIVAAAGVAGLVTKENVKPGAAVLDVGVSRVLDPATGKSKLAGDVALDVAEVAGFVAPNPGGVGPMTRALLLTNVVESAERAAGLR

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Acaryochloris marina (strain MBIC 11017)

Length

295 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.204 kDa

Sequence

MPVESSKLLDGKGLAQKIQGELTAQIQTLQAEIGRPPGLAVLMVGDNPASAAYVRNKERACERLGIASFGHHFPAEVTFEEVKQTIHDLNANPQVDGILVQLPLPAHLDSTALLYEIDPDKDVDGLHPLNLGRLVRGEAGLRSCTPAGVMRLLAAYDVELSGLHAVVIGRSILVGKPVSLMLLAANATVTMAHSRTPDLAAVTRTADVLVAAVGKPGLITADMVKPGAVVIDVGISRQEIEGKARLVGDVEFTSVQSQSSLITPVPGGVGPITVSMLLENTVWSFRQRHKGSYNS

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Pelodictyon phaeoclathratiforme (strain DSM 5477 / BU-1)

Length

295 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.906 kDa

Sequence

MLIIDGKKVSLDLKNELKASVDNFRSITGKVPGLTVIIVGQDPASQVYVRNKAKTCKEIGMISTVIEMADDTTEKHLIETIHKLNNDPTVHGILVQQPLPKQIDEFAVTLAIDPSKDVDGFHPENLGRLVMGHLDKCFVSCTPYGILELLGRYNIETRGKHCVVVGRSNIVGKPMANLMLQKLDATNCTVTICHSATKNIPFYTLQADILIAAIGKAGFITADMVKPGAVVIDVGINRIEDPSTKSGYRLVGDVDFEAVSTVASAMTPVPGGVGPMTIAMLLKNTLQSFQRINNL

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB)

Length

295 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.48 kDa

Sequence

MAAKLLKGAEVAKEIRAELKTEVEQLQSKHGVVPGLVTILVGENPASQSYVRAKQNTAHELGFHSVQDNQPADLEENRLLDLIDKYNKDPSIHGILVQLPLPKHINENRILLSIDPSKDVDAFHPVNVGKLMIGEPDYLPCTPAGIQELLVRSGTQVSGAEVTIVGRSNIVGKPIAMMLVQKANGANATITVCHTRTKDVASHTRRADILIVAAGVAEYVKGNMIKPGAVVIDVGVNEVGKTADGKRILKGDVAFDEAVEVASAITPVPGGVGPMTITMLMKNTVRACKVHNKIA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Bordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)

Length

294 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.54 kDa

Sequence

MTRQDASTPAPSGARIIDGAALAQRIREDVARRVQALAAKGVRPGLAVVLVGDDPASQVYVRNKVAACEKAGLYSIKEQYPADMTEAELLARIDTLNRDPAIHGILVQLPLPPHMSSHKVIEAIAAEKDVDGFHISNAGLLMTGQPLFRPCTPYGVMKMLEAEGVPLRGAEAVIVGASNIVGKPMAMLLLQAGATITICNSKTRDLAAQTRRADVLVVATGKPGMIDGSMIKPGAVVIDVGINRGADGKLCGDVDFASAREVAGAITPVPGGVGPMTIAMLLVNTVEAAERTAG

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)

Length

294 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.507 kDa

Sequence

MTAKIIDGKVIAADLRARVADEVARVKREHNLVPGLAVVLVGNDPASEVYVRSKGTQTQAAGMASFEHKLPADVSQADLLAVVAKLNRDPAVHGILVQLPLPKGLNTEAVINAIDPAKDVDGLHPNNAGRLAGGFEALSPCTPLGSIILTKSVHPSLEGLNAIVIGRSNLVGRPLVQLLLNENATVTIAHSRSRDLPGLVKRADLVYAAVGKPEMVRGDWLKPGATVIDIGISRIPKEDGKTRLVGDVAYQEALGVAGAITPVPGGVGQMTVACLLVNTLRAACAIAGLPKPAV

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182)

Length

294 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.706 kDa

Sequence

MTARIIDGKVIAADLRGQVAREVERVKRDHGLTPGLAVVLVGNDPASEVYVRSKHTQTQAAGMASFEHKLPADVAQSELLALIDKLNHDPSVHGILVQLPLPKGLETEIVINAIDPAKDVDGLHPHNAGRLSGGQPALAPCTPLGCIILSKTVHPSLEGLNAIVIGRSNLVGRPLVQLLLNENATVTIAHSRSRDLAALTARADLVYAAVGRPEMVKRDWIKPGATVIDVGINRIPTAEGKTRLVGDVAYAEVAEVAGAITPVPGGVGQMTVACLLVNTLRAACAIAGLPKPAV

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Bradyrhizobium sp. (strain ORS 278)

Length

294 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.626 kDa

Sequence

MTARIIDGKIIAADLRAQVAREVERVKHDLGLTPGLAVVLVGNDPASEVYVRSKHTQTQAAGMASFEHKLPADVAQAELLALISKLNQDPSVHGILVQLPLPKGLDTEAVINAIDPAKDVDGLHPHNAGRLAGGQPALAPCTPLGCIILSKTVHASLEGMNAIVIGRSNLVGRPLVQLLLNENATVTIAHSRSRDLPALTARADLVYAAVGRPEMVKRDWIKPGATVIDVGINRIPTPEGKTRLVGDVAYAEVAEVAGAITPVPGGVGQMTVACLLVNTLRAACAIAGLPKPSV

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Hahella chejuensis (strain KCTC 2396)

Length

294 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.675 kDa

Sequence

MTMTHAQNNHHARLIDGKQVAADVRANVAEGVKARIDSGLRPPGLAVVLVGEDPASQVYVKNKTKACEEVGFLSQKYTLEESTTEEELLKLIDTLNEDNAIDGILVQLPLPTHMDADNILERIKPDKDVDGFHPYNLGRLAQRMPVLRPCTPKGIMTLLARTGVELRGKDALVVGASNIVGRPMGLELLLAGCTVTITHRFTVNLPAKVSQADIVVVAVGRPGIVKGEWIKPGAIVIDVGINRRDDGALVGDIEFNEAAERASWITPVPGGVGPMTVATLMENTLYAANHLHKD

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Xanthomonas campestris pv. campestris (strain 8004)

Length

294 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.932 kDa

Sequence

MTAPAPAALAPARLLDGRRIAEELLDGLKLRVDARLAAGKTRPGLAVVLVGGDPASSVYVRNKRRAAEKVGIEAFDYDLPQGTTEAELAALIDQLNTDPKIHGILIQLPLPGIPDANRLIQRIDPRKDVDGFHPQNVGHLALREFGLRPCTPRGIVTLLAHTDQPVRGRNATIVGVSNHVGRPMGLELLIAGCTVTSCHKFTPPDVLEASVRNADILVVAVGRPGLIPGEWVKPGAVVIDVGINRLDDGRLVGDVGFEAAAQRAGWITPVPGGVGPMTVATLMQNTLEAADAAG

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Xanthomonas campestris pv. campestris (strain B100)

Length

294 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.932 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)

Length

294 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.932 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Nitrobacter hamburgensis (strain DSM 10229 / NCIMB 13809 / X14)

Length

294 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.469 kDa

Sequence

MTASIIDGKVIAADLRARVAFEVARVKRDHGLTPGLAVVLVGSDPASEVYVRSKHKQTQAAGMASFEHVLPADVAQPDLLALVARLNADPAVHGILVQLPLPKGLDTETIVAAIDPAKDVDGLHPHNAGRLAGGLPALSPCTPLGCIILTKSVHSSLEGMDAIVIGRSNLVGRPLVQLLLNENATVTIAHSRSRNLPELCRRADLVYAAVGKAEMVRGDWLKPGATVIDVGITRRPAADGKTRLIGDVAFDEAMEVAGAVTPVPGGVGQMTVACLLVNTLRAACAIKGLPAPGV

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Flavobacterium psychrophilum (strain JIP02/86 / ATCC 49511)

Length

294 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.884 kDa

Sequence

MILLDGKKTAQDIKNEITAEVNKMKANGEKVPHLAALIVGSDGASLTYVGSKVKACELVGFESTLVKMPSTTSETELLKKIKELNQNDDIDGFIVQLPLPEQIDTQKVLMTIDPSKDVDGFHPENFGKMALDMTTFIPATPFGILELLERYGVETKGKHTVVIGRSHIVGRPMSILMGRKGFPGNSTVTLTHSYTKNIAQITTQADIIISALGVPNYLKAEMVKDGAVIIDVGITRVPDETNEKGYVITGDVDFENVSKKASHITPVPGGVGPMTIAMLLKNTLLAREQRKVNN

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Nitrobacter winogradskyi (strain ATCC 25391 / DSM 10237 / CIP 104748 / NCIMB 11846 / Nb-255)

Length

294 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.34 kDa

Sequence

MAASIIDGKVIAADLRARVAGEVTRIKRDHGLTPGLAVVLVGNDPASEVYVRNKHKQTQAAGMASFEHMLPADVAQADVLALIAELNADPAVHGILVQLPLPKGLDTEAIIAAIDPAKDVDGLHPHNAGRLAGGLSALSPCTPLGCIILTKSVHASLEGLDAIVIGRSNLVGRPLVQLLLNENATVTIAHSRSRNLPELCRRADLVYAAVGRAEMVRGDWLKPGATVIDVGITRVPAAEGKTRLIGDVAFDEAMQVAGAVTPVPGGVGQMTVACLLVNTLRAACAIEGLSAPGV

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Oligotropha carboxidovorans (strain ATCC 49405 / DSM 1227 / KCTC 32145 / OM5)

Length

294 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.313 kDa

Sequence

MPATRIDGKAIAAKLREDVAAEVARLKRDHDLTPGLAVVLIGNDPASEVYVGSKTKQTVAAGMASFEHKLAADTPQAQVLALIARLNRDPAVHGILVQLPLPKGLDATIIVNAIDPAKDVDGLHPVNAGRLASGLPALTPCTPLGCIILAKTVHASLEGMNAIVLGRSNLVGRPLVQLLLNENATVTIAHSRTRNLPALCRQADLVFAAVGRPEMVKGDWIKPGATVIDVGINRLPGEGGKSRLVGDVAYAEAMEVAGAVTPVPGGVGQMTVACLLVNTVRAACAIKGLSAPSV

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Renibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235)

Length

294 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.794 kDa

Sequence

MTAQILDGKKAAAEVKSELVERIAALVARGITPGLATVLVGDDAPSQSYVRMKHQDANALGLASFERHLPAETSQDELDAVIDELNANPGVHGILVQIPLPKHLDEQAVLERIDPDKDADGLHPVNLGRLVLNVNGVITSPLPCTPVGAIQLMLRNGIELAGKHVVVVGRGITVGRALGLLLTRREINATVTLTHTGTVDLAAHLRQADVVISAVGVAHMIKAENLKPGVVVLDVGVSRERDEVTGKSKLLGDVAPDVADVASWISPNPGGVGPMTRALLMSNVVQAAEAVSSR

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Synechocystis sp. (strain PCC 6803 / Kazusa)

Length

294 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.943 kDa

Sequence

MTAVPPSCQILDGKALAQKMQGELQRDIAQLVAQGHRSPGLAVLMVGDNPASAVYVRNKEKACEKLGMVSFGKHFSADTDQETLTAAIASLNEDERVDGILVQLPLPDHLDAVKLLHTIDPSKDADGLHPVNLGHLVRGEEGLRSCTPAGVMALLAEYNLDLTGKNAVVLGRSILVGKPLALMLLEKNCTVTIAHSRTQNLADITRQADILVAAIGKPEFVTADMVKPGAIVVDVGINRLDLGEGKSTLVGDVDFAGVAPVASYLTPVPGGIGPMTVTLLLANTVASYRQRLGI

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Azobacteroides pseudotrichonymphae genomovar. CFP2

Length

293 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

32.037 kDa

Sequence

MTLMDGRAIAAQIKLEITKEVQQIVINGEKKPHLAAILVGHDCSSETYVANKVKTCEELGFQSTLIRYESDLIENKLLATVEKLNQDSNIDGFIIQLPLPKHISEQKVIEAIDYKKDVDGFHPVNAGRMAIGLPCFVPATPAGILELLKRYKITTAGKHCVVLGRSNIVGKPIANLLMRKAYPGDCTVTVCHSRTKNILKHCLEADIIIAAMGVPEFLKGNMVKDGVVVIDVGTTRVLSTETDSGFKLRGDVRFKEVAPKCSYISPVPGGVGPMTIISLMRNTLLARKKVIYS

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Cyanothece sp. (strain PCC 7425 / ATCC 29141)

Length

293 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.036 kDa

Sequence

MADSFPNLLDGKALAQEMQADLTLQVQALQTRVGRPPGLAVLMVGDNPASAAYVRNKERACEQVGIASFGHHLPTETTQAELLTLINQLNQDPRVDGILVQLPLPNHLDARALLYAIDPTKDADGLHPENLGRLVRSEPGLRSCTPAGVMRLLQKYNIELRGKEAVVIGRSILVGKPLAMMLLEADATVTIAHSRSTDLAEIARRADILIAAVGKPGLVSAGMVKAGAVVVDVGINRVVEATGKSRLVGDVDFAAVQPIAGYITPVPGGIGPMTVAMLLDNTVCSFQQRNGLK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Azobacteroides pseudotrichonymphae genomovar. CFP2

Length

293 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

32.037 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Cyanothece sp. (strain PCC 7425 / ATCC 29141)

Length

293 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.036 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Treponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222)

Length

293 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.292 kDa

Sequence

MSAKIIDGARIAADLRADIAKDVEKIKAKGVQPTLAVILVGNDPASQSYVKGKTNALHEVGMNDRTFRLPETTTQDELLKLIKELNADKLINGILVQLPLPKQIDPDAVIEAINPEKDVDGFHPVNVGKLLLGHDTFIPCTPHGVIHLLKRTGVETKGAKVVIVGRSNIVGKPLSVLMMNKDVNATVTVCHSGTKNLTEVTKEADILVAAMGKPRFIKADMIKKGAVVIDVGVNRIDDSTKKSGFRLVGDVDFEPACEIASAITPVPKGVGPMTIAMLVANTLIAAKRQNGLE

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Opitutus terrae (strain DSM 11246 / JCM 15787 / PB90-1)

Length

293 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.549 kDa

Sequence

MTLIDGSKIAATIVAELKAEVAALTGRKPCIALVRIGEDPASVSYVKNKERTAAEIGLTGRVILPPVTISQAELFALIDGLNADAGVDGILVQAPMPKHLDELQVFRRIAPEKDVDGLGTMNLGKVAQDDDTGFVSCTPAGIMELLSRSGVDLKGKHVVVVGRSLLVGKPVALLALQKKAGANGTVTICHSATKDLPAITRQADVLIAAIGRAGFVTADMVKPGVVVIDVGINRVPDSTKKSGYRLVGDVDFPAVSPLASQITPVPGGVGPMTVAMLMKNTVKAYRLRQHRAG

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Mycoplasma arthritidis (strain 158L3-1)

Length

293 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

32.036 kDa

Sequence

MPVILDGKRLSEALQAKIAMAFSAYRGPKPILGILQVGNKEDSNIYVAHKLKVAESLGFLTKLVKMPENSTQDEIIGTLRNAAAEVTGIIVQLPLVSNRIENLQEILDNIPIEKDIDGLSSYNLASNYNCKDNFLSATPKGIILLLKHYNINFRSTVIALVGQSNIVGKPLAKYLSNFKNNTIKTYVKDTPKDDLHEAKIVIVATGVYQSVTADQLANGTVLIDVGIHRQGKTIHGDLDFASCFKKASYITPVPGGVGPLTVVALMFNLIKALILQNPNLDHEFLSLKEFINI

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)

Length

293 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.589 kDa

Sequence

MSAKIIDGKTIAQQVRNEVAALVQKRLAAGKRAPGLAVVLVGENPASQIYVASKRKACEEVGFVSRSYDLPMTTTEAELLALIDSLNNDSEIDGILVQLPLPAGIDNVKVLEHIHPDKDVDGFHPYNVGRLCQRAPKLRPCTPRGIVTLLERYDIPTYGLNAVVVGASNIVGRPMSLELLLAGCTTTVTHRFTKNLRQHVENADLLVVAVGKPGFIPGEWIKPGAIVIDVGINRLESGKVVGDVEFDVAVERAGWITPVPGGVGPMTVATLIQNTLQACEEYHDINENRVKGQ

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / JCM 11019 / NCTC 9343)

Length

293 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.625 kDa

Sequence

MTLIDGKAISEQVKQEIAAEVAEIVAHGGKRPHLAAILVGHDGGSETYVAAKVKACEVCGFKSSLIRYESDVTEDELLAKVRELNEDDDVDGFIVQLPLPKHISEQKVIETIDYRKDVDGFHPINVGRMSIGLPCYVSATPNGILELLKRYRIETSGKKCVVLGRSNIVGKPMAALMMQKAYPGDATVTVCHSRSKDLVKECREADIIIAALGQPNFVKAEMVKEGAVVIDVGTTRVPDASKKSGFKLTGDVKFDEVSPKCSFITPVPGGVGPMTIVSLMKNTLLAGKKAIYQ

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Bacteroides fragilis (strain YCH46)

Length

293 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.625 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)

Length

293 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.646 kDa

Sequence

MTLIDGKAISEQVKQEIAAEVAEIVARGGKRPHLAAILVGHDGGSETYVAAKVKACEVCGFKSSLIRYESDVTEEELLAKVRELNNDDDVDGFIVQLPLPKHISEQKVIETIDYRKDVDGFHPINVGRMSIGLPCYVSATPNGILELLKRYEIETSGKKCVVLGRSNIVGKPMASLMMQKAYPGDATVTVCHSRSKDLVKECQEADIIIAALGQPNFVKEEMVKEGAVVIDVGTTRVPDASKKSGFKLTGDVKFDEVAPKCSFITPVPGGVGPMTIVSLMKNTLLAGKKAIYK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)

Length

293 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.506 kDa

Sequence

MTAQILDGKATAAAIKSDLTVRVAALKAQGITPGLGTLLVGDDPGSRWYVNGKHRDCAQVGIGSIQRELPDTATQEEIEEVVRELNANPECTGYIVQLPLPKGIDTNRVLELMDPEKDADGLHPMSLGRLVLNETGPLPCTPQGVVQLLRAHGVEINGAHVVVVGRGVTIGRSIPLLLTRKSENATVTQCHTGTRDLSSHLRQADIIVAAAGVQHLIKPEDVKPGAAVLDVGVSRDADGKIVGDVHPGVREVAAWVAPNPGGVGPMTRAQLLVNVVEAAERAAAEAADAAAAG

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Acidothermus cellulolyticus (strain ATCC 43068 / 11B)

Length

293 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.192 kDa

Sequence

MGAVILDGRAVAADILAELTERVGRLRGQGVLPGLGTVLVGDDPASHAYVAGKHRDCAKVGIASIERTLPASASQAEVAAVIDELNADPACTGYIVQLPLPAGLDEVAVLERMDPAKDADGLHPVNLGRLVLMRPGPLPCTPRGCLELLRRYEVPIAGADVVVIGRGITVGRALGLLLTRRSENATVTTCHTGTKDLAAHVRRADIVVAAAGVPGLVTPDIVKPGAAVLDVGITRVIGDDGRARYTGDVHPDVREVAGWLAPMPGGVGPMTRAMLLANVVEAAERQAGFPAAS

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Leifsonia xyli subsp. xyli (strain CTCB07)

Length

293 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.485 kDa

Sequence

MSARTLDGKATAAAIKAELRERVSALRERGVVPGLGTILVGDDPGSQWYVAGKHRDCAEVGIASLRRDLPAEISQAELEAVVEQLNADPGCTGFIVQLPLPSHLDTDAVLELVDPAKDADGLHPTNLGRLVLNVNRPITTPLPCTPRGVIELMLRHGIDLAGKDVVVVGRGVTVGRSIGALLTRREVNATVTLTHTGTKSLDEHLRSADVIVAAAGVPGLVSAENVKPGAIVLDVGVSRVEDPETGKSRVAGDVAADVAGVASWISPNPGGVGPMTRALLLQNVVESAERALR

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / NBRC 14291 / NCTC 11154)

Length

293 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.534 kDa

Sequence

MQLIDGKAISELVKQEIAAEVAGIVAKGGKRPHLAAILVGHDGGSETYVAAKVKACEVCGFKSSLIRYEADVTEEELLAKVRELNEDADVDGFIVQLPLPKHISEQKVIETIDYRKDVDGFHPINVGRMSIGLPCYVSATPNGILELLKRYHIETQGKKCVVLGRSNIVGKPMASLMMQKAYPGDATVTVCHSRSKDLVKECQEADIIIAALGQPNFVKAEMVKEGAVVIDVGTTRVPDATKKSGFKLTGDVKFDEVAPKCSYITPVPGGVGPMTIVSLMKNTLLAGKKAIYK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Syntrophus aciditrophicus (strain SB)

Length

293 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.081 kDa

Sequence

MAAIIIRGSDIAQEIREDLKKEAAWLKAYGVVPGLVTILVGQDPASMSYVTAKQKTACKLGFYSLQDSQPGHVSESLLLDRIARYNKDPRIHGILVQLPLPPHIDEQKILYAIDPGKDVDGFHPYNVGKLMIGQADFLPCTPAGIQQLLIRSGIQTDGAEVVVVGRSNIVGKPIANMLLQKQKGANATVTVCHTGTRDVGVHTRRADILIVAAGKPKAITADMVKEGAVVIDVGVNRVGVTSDGKAKLCGDVDFEPVREKAGAITPVPGGVGPMTITMLMVNTLKAARLSAGL

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Synechococcus sp. (strain JA-2-3B'a(2-13))

Length

293 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.081 kDa

Sequence

MPAKILDGKALAARLQAEMAAQVQAWIPQVGRPPGLAVLRVGEDPASAAYVRGKERACERLGIASFGRHFSAQDSPAHLLDTIDQLNQDERVDGILVQLPLPPGWDPIPPLLAINPDKDVDGLHPLNLGRLLRGEPGLRSCTPLGVMRLLQAEGIPIAGRKAVVVGRSILVGKPLSLMLLAADATVTLAHSRTPDLAEVTRAADIVVMAVGRPRLLRADMVKPGAVVIDVGINRIETPTGAEQLVGDVDYEAVKELAAAITPVPGGVGPMTVTMLLANTLQSYKLRSHLCSHY

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Synechococcus sp. (strain WH7803)

Length

293 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.443 kDa

Sequence

MALRLDGKALAKELEQRLAQQVRSGCAKAGRPPGLAVLRVGDDPASAVYVANKEKACARVGVESFGAHLPASSQPETLLKTIQALNADERVDGILLQLPLPAGLDETPLLAAIDPDKDADGLHTLNLGRLLKGEPGPRSCTPAGVMAMLRSQGIDPSGKRAVVVGRSILVGQPMALMLQAANATVMVAHSRTRDLAALTRQADILVVAAGRPEMIGAEHVAPGAVVVDVGIHRRPEGGLCGDVNAAELEPLAAALSPVPGGVGPMTVTMLLVNTVLAWSRRHQLDHDLADLVP

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Synechococcus sp. (strain WH8102)

Length

293 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.223 kDa

Sequence

MALRLDGKALAATVERRLTSVVDAHSKTVGQPPGLAVLRVGDDPASAVYVANKEKACARVGIASYGAHLAADTPADQVLSTIQSLNADPRVDGILLQLPLPKGLDERPLLEAIDPEKDADGLHTLNLGRLLKGEPGPRSCTPAGVMALLRSNGIDPAGQRAVVIGRSILVGQPMALMLQAANATVTVAHSRTADLAAHTREADIVVVAAGRPGMVGAEHVRPGAAVVDVGIHRKPEGGLCGDVVAEEVEPIAAALSPVPGGVGPMTVTMLLVNTVVAWCRRHGIDHELDDLIG

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Synechococcus sp. (strain CC9311)

Length

293 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.899 kDa

Sequence

MALRLDGKQLAAQLEVRLQQQIQKGIAAAGRSPGLAVLRIGDDPASAVYVRNKEKACARIGVESFGSHLPADASQQEVLTAIRELNADDRVDGILLQLPLPEGLDETPLLAEIDPNKDADGLHTLNLGRLLKGEQGPRSCTPAGVMVMLRDQGIDPAGKRAVVVGRSILVGQPMALMLQAANATVTVAHSRTQHLESITRQAEILVVAAGRPEMIGADHITPGCVVVDVGIHRRPEGGLCGDVCAEELEPVAAALSPVPGGVGPMTVTMLLVNTVLAWCRRHQVALELSDLVV

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Synechococcus sp. (strain CC9902)

Length

293 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.375 kDa

Sequence

MALRLDGKALAKAVESRLQAQIESNLPQAGRPPGLAVLRVGDDPASAVYVANKEKACARIGVASYGAHLPSSTPFAEVLSTIQQLNADPRVDGILLQLPLPEGLDEGPLLMAIDPEKDADGLHTLNLGRLLKGEQGPRSCTPAGVMAMLRSQGIDPAGQRAVVIGRSILVGQPMALMLQAANATVTVVHSRTKDLVAHTREADIVVVAAGRPGMVGAEHIKPGAAVVDVGIHRKPEGGLCGDVRAAEVEPIAAALSPVPGGVGPMTVTMLLVNTVVAWCRRHGVDHDLADLLS

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Synechococcus sp. (strain CC9605)

Length

293 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.604 kDa

Sequence

MALRLDGKVLARDVEHRLQTLIERCLAEAGRPPGLAVLRVGDDPASAVYVANKEKACARIGVASFGDHLPGDTPPALVLQTIERLNANPEVDGILLQLPLPAGLDEGPLLMAIDPEKDADGLHTLNLGRLLKGEPGPRSCTPAGVMAMLRSNGIDPAGKRAVVIGRSILVGQPMALMLQAANATVTIAHSRTADLAAHTREADILVVAAGRPEFIGAEHVRPGAAVVDVGIHRKPEGGLCGDVRAAEVESIAAALSPVPGGVGPMTVTMLLVNTVVAWCRRHNLDHDLDDLVP

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Helicobacter acinonychis (strain Sheeba)

Length

292 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.838 kDa

Sequence

MGMPNKGVVLLDGQALAYNIEEDLKYKIQAINTQTHKRPKLAVILVGKDPASITYVNMKIKACERVGMDFDLKTLQENITEAQLLSLIKDYNNNQNISGVLVQLPLPRHIDSKMISEAIDPNKDVDGFHPLNIGKLCTQKESFLPATPMGVMRLLEHYHIGIKGKDVAIIGASNIIGKPLSMLMLNAGASVSVCHILTKDINFYTQNADIVCVGVGKPDLIKASMLKKGAVVVDIGINHLNDGRIVGDVDFTNAQKVASFITPVPKGVGPMTIVSLLENTLIAFEKQQRKGF

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Wolbachia pipientis wMel

Length

292 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.582 kDa

Sequence

MTIIIDGKKIANDLCERLSQKIDILKREYNIFPCLKVILIGSNPASQVYVRNKQKKAESIGISSETIVLPNNILEDELIEKINELNEDPSVHGILVQLPLPNHISASRVINTVSVEKDVDGFHDENVGKLVKGEKNCLIPCTPKGSLHLIKSIEENLSGKNAVVIGRSNIVGKPMFYLLLQENCTVTILHSQSKDLAEYCSKADIVVAAVGKPNFVQADWIKKGAIVIDVGINSVNVGKLVGDVDFEGIKGKAKAMTPVPGGVGPMTIAFLMMNTVIAACLQKGVDASDFIS

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Wolbachia sp. subsp. Drosophila simulans (strain wRi)

Length

292 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.542 kDa

Sequence

MTIIIDGKKIANDLCERLSQKIDILKREYNIFPCLKVILVGSNPASQVYVRNKQKKAESIGISSETIVLPDNISEDELIEKINELNEDPSVHGILVQLPLPNHISASRVINTVSVEKDVDGFHDENVGKLVKGEKNCLIPCTPKGSLHLIKSIEENLSGKNAVVIGRSNIVGKPMFYLLLQENCTVTILHSQSKDLAEYCSKADIVVAAVGKPNFVQADWIKKGAIVIDVGINSVNVGKLVGDVDFEGIKGKAKAMTPVPGGVGPMTIAFLMMNTVIAACLQKGVDASNFIS

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Arthrobacter globiformis

Length

292 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.094 kDa

Sequence

MTASLLSGKPLAKLIQQQAQTEAKVLAEEGTCPTLAVVVATEDSSTHWYVRSIERAAEAAGINCRIIDVGHDATEQVLIAVLKDLSAELSVNGIILQTPLPPGVRTQELVKYIAPEKDIDGANPLSLGLLAVGERAFAPATARAVVEILDHFEIPVAGRNVVVVGRSTVVGKPLSLLLLQKDATTTVCHSKSGALGTYTKTADVVVVAAGRTGLLTGADVSEHSVVIDVGTNVLSDGSLTGDVDEASVRPVAAALTPVPGGVGSVTTALLLLHTAEAAREQSRATSAPVLTR

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Arthrobacter globiformis

Length

292 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.094 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Cyanothece sp. (strain PCC 8801)

Length

292 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.059 kDa

Sequence

MSSDTAALLNGKALAKKIQLELQTWIQELHPKIGRPPGLAVLMVGDDPASAVYVRNKEQACAKVGIESFGNHFPADTSQEALEAVIEQLNQDPRVDGILVQLPLPPHLDAVALLHKIDPNKDADGLHPTNLGRLVRGESGLRSCTPAGVMRLLEEYQIKVAGKQAVVVGRSILVGKPLALMLLEENATITIAHSRTQDLASITRQADILVAAIGKPEFITAEMVKPGAIVVDVGINRIIRPDGTAQLVGDVDFNGVAGVAQYITPVPGGIGPMTVAMLLRNTVLSYQGIHNT

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Desulfovibrio magneticus (strain ATCC 700980 / DSM 13731 / RS-1)

Length

292 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.438 kDa

Sequence

MLLIDGKKVAAELRQRVKNDVDALVRQHGRAPHLAVILVGEDPASQIYVRYKEKACEEVGFVSRIWRLDGGIGQCALEKLITELSSSEDIDGILLQLPLPKGLDAQRCLALVDPKKDVDGFHPENVGRLSIGLPCLKPCTPFGVIKLLEYYGLSPAGKRAVVIGRSNIVGKPMAMLLSAASPFGNATVTVCHSRTPDLAAVVREADFIVPAIGKPKLITRDMVKPGAVIVDVGMNRLPDGKLCGDVDYDNLTDVASAMTPVPGGVGPMTIATLMSNTVEAYRWRRQPPDCPI

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Nostoc punctiforme (strain ATCC 29133 / PCC 73102)

Length

292 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.829 kDa

Sequence

METKTAKLLDGKAIAAKIQQELSVAITQLQPEIGRPPGLAVLMVGDNPASAAYVRNKEKACAKVGIASFGKHFPAETTFRELEKVIAALNDDERVDGILVQLPLPDHLDAVALLHQIDPDKDADGLHPVNLGRLVRGEIGLRSCTPDGVMRLLQEYEIPLQGKQAVVVGRSILVGKPMALMLLEADATVTIAHSRSHDLKSITQNADILIAAAGRPGLITADMVKPGAVVVDVGMNRVTDASGKSRLIGDVDFESTAGVAGFITPVPGGVGPMTVAILLQNTFTSYSRAAKK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Protochlamydia amoebophila (strain UWE25)

Length

292 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.744 kDa

Sequence

MIIDGKRIAEEIQLEIKELIQQSLCRPPCLAVLIVGSHPASQIYVNRKTAACKAVGIASIKCELPFTISEEELIREVEKLNVDPQIDGILVQLPLPPHINSNRVNYHIDPQKDVDGFHPLNVGKMLIGELDGFLPCTPFGIKTLLERTGIEVCGKHALIIGRSNIVGKPMAALLMQSYPGGNATVTVAHRYTKNLKELCLQADLIIVAIGQPKLITADMVKEGVIIVDVGINKIHDSSKKNGYQIVGDVDFVNVAPKCAFITPVPGGVGPMTIAMLLYNTLLSYSKSQNLNL

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Bifidobacterium longum (strain NCC 2705)

Length

292 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.062 kDa

Sequence

MMSTKIDGKQIAAEIKTNLAERVNKLKAQGIQPGLGTLLVGEDPGSMKYVAGKHADCQEVGITSVKKELPADASFDDIAAAVRELNEDPACTGFIVQLPLPKGINENAIIDMIDPAKDADGMHPYNLGELVLHVRGDISTPLPCTPRGVLELLDAYDIDLNGKEVCVLGRGITIGRTIGLMLTRNAVNATVTLCHTGTRDVADHMRRADVIVAAMGSAGFVTPDKIKDGAVLVDVGVSRVYDEEAGRYRIKGDVDKACYDKASAYTPNPGGVGPMTRAMLLANVVEMAERHA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Synechococcus sp. (strain RCC307)

Length

292 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.118 kDa

Sequence

MPAQRLDGRQLAAQLEEVMAAAIASGLPRAGRPPGLAVLRVGDDPASGVYVANKEKACARVGLVSHGAHLDAATPQAEIEAKLRQLNQDPAVDGILVQLPVPAGLDDRALLLELDPAKDADGLHPLNLGRLLRGEPGPRSCTPAGVMALLRSNGIDPAGKRAVVIGRSILVGQPMALMLQAANATVTVVHSRTADLAAHTREAEILVVAAGKPGMIGADHVRPGAAVVDVGIHRKPEGGLCGDVRSAEVEPIASALSPVPGGVGPMTVTMLLLNTVRAWSQRFDLPDPTPGY

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Psychrobacter sp. (strain PRwf-1)

Length

291 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.961 kDa

Sequence

MNDATATRLDGKALAKQIETELSQRVAAVIKKTGRTPILATILVGDDPASATYVRMKGNACKRVGMESIRVEMPASTTTEQLLAKIDELNNNPDVHGILLQHPVPEQIDERACFDAIDLNKDVDGVTSLGFGRMSMGEPAYGSCTPQGIMYLLERYFLKNGIEFAGKNAVVVGRSAILGKPMAQMLLNANCTVTICHSKTQNLEEHVGRADILVGAVGVPELIKKDWIKPGAIVVDAGFHPTEDGGVGDIELKGIESIAAAYTPVPGGVGPMTINTLIRQTVEAAEKAAQA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Aquifex aeolicus (strain VF5)

Length

291 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.93 kDa

Sequence

MALILDGKSLSKKIREEIKKEVENFTSKGFRPPALAVILVGNDPASEIYVNNKRKACEKVGIKSLFYHLPQDVSEEKLLGLIYELNMNEEVDGILVQLPLPKHIDQTRVILSISPEKDVDGFHPENMGKLVAQIEDGFIPCTPLGIDILLKHYGIDVKGKDVTIVGAGFIVGRPLSLLMLWRNATVSVCHIHTKDVKKFTKEADILISATGVPHLIKEDMIKEGAVVVDVGISRLNGKIVGDVDFERVKEKASAITPVPGGVGPMTVTALLLNTLKSYKRKFAHLISTTNP

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Azoarcus sp. (strain BH72)

Length

291 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.187 kDa

Sequence

MSARIIDGNALAARVRGEIAARAAALTDRGTQPCLAVLLVGENPASAVYVRSKVAACEKAGIRSLRFDYPQDVDPAVVMEKLAALNADPSVHGILVQLPLPPQFDEAAVLEAISVAKDVDGFHAENVGRLSQNQEAFLPCTPHGVMKMLEAEGVPLAGAEAVVIGRSNIVGKPMAMLLTNAGATVTVCHSRTRDLRFHTGRADIVVAAIGKPRFVTGDMLKPGATVIDVGINRITDGPEAGKLCGDVDFASASEVAGLITPVPGGVGPMTITMLLENTVISAERSARAAGK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Aquifex aeolicus (strain VF5)

Length

291 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.93 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Azoarcus sp. (strain BH72)

Length

291 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.187 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Dichelobacter nodosus (strain VCS1703A)

Length

291 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.659 kDa

Sequence

MSAEIINGKEIAAEIRREIKQETAQFIAATGVRPGLAVILVGNDPASEVYVRNKGIQAEEVGFLSQIYRLPAQTTQAELLAKIVALNNDPQICGILVQLPLPAHLNAEIVLNTIDPNKDVDGFHPLNIGRLWAGEPCSVPCTPLGCSLILKRYFGDSLAGKKALIIGRSNIVGKPMAALLLQQHATVTIAHSKTPDVPALCRQADIVIAAVGQPELVKGDWIKSGAVVLDVGINRIAVGDKTKLVGDVAFESAKEVAAAITPVPGGIGPMTIACLLKNTLTLAKAIQQSGK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Akkermansia muciniphila (strain ATCC BAA-835 / Muc)

Length

291 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.847 kDa

Sequence

MQIIDGKQVASQVLEEVERDIARLREQGITPGLAVVLVGEDPASQVYVNSKVKKCAELGMNSRKIVLPSDASQEELLRIVRELNVDPSVHGILVQSPPPPHIDEAAVVLEIDPAKDVDGFHPENVAKLVLEDETGFVPCTPLGCMRLLKAAGIETAGANAVVIGRSMIVGKPMAHLLMSKQANATVTVAHSRTKNLPELCRSADIIVAAIGRPAFVTADFVKDGAVVVDVGINRVEDASAKRGYRIVGDVAYDEVAPKCRAITPVPGGVGPMTIAMLMANTVKACRQQTGA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Xylella fastidiosa (strain Temecula1 / ATCC 700964)

Length

291 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.002 kDa

Sequence

MLAATDLARILDGRRIADDLLDALKTRVDARVAAGKLPPTLAVVLVGSDPASVVYVRNKRRAAEKVGIKAYDFDLPEATTEAELAALIDRLNADPKIHGVLIQLPLPGIPDAHRLIQRIDPRKDVDGFHPQNVGHLALREFGLRPCTPRGIVTLLGHTDRPVRGRNATIVGVSNHVGRPMGLELLMAGCTVTSCHKFTPPQMLEAAVRQADILIVAVGRPGVIPGEWVKPGAVVIDVGINRLDDGQLVGDVGFESAVKRASWITPVPGGVGPMTVATLMQNTLEAAEATDC

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Leptospira biflexa serovar Patoc (strain Patoc 1 / Ames)

Length

291 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.729 kDa

Sequence

MKSSILLDGKAISEKIRNRIQETLAKAKAEGKGIPTLATILVGNNPASETYVNMKVKACEKVGMHSRYIRLKEETTTEELLGEIRKLNLDPSINGILLQHPVPHQIDERKAFDEIALEKDVDGVTTISFGKLSMNSEAYYPCTPYGMVLLLQEYGIDVTGKHAVVVGRSPILGKPMAIMLTNLNATVTLCHSKTEDLPSLVKQADIIVGAVGKPEFIKAEWMKEGVVILDAGYNVGNVGDIEVSKAKDKSSYYTPVPGGVGPMTISVLLLQTMYSFLGQFSPKLESHVANR

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)

Length

291 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.23 kDa

Sequence

MNNIIDGKALANEILADLKLEIQELKSQTNTSPKLAIVLVGDNPASIIYVKNKIKNAHKIGIDTLLVNLSTTIHTDDLISKINELNLDNEISGIIVQLPLPSSIDKNKILSAVSPSKDIDGFHPLNVGYLHSGISQGFIPCTALGCLAVIKKYEPNLTGKNVVIIGRSNIVGKPLSALLLKEDCSVTICHSKSQNLSSITSKADIVVAAIGSPLKFTTEYFDPESIVIDVGINRISGNKIIGDVDFENVKSKVKYITPVPGGIGPMTIAFLLKNTVKAFKDSYSTVCHSCL

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Bifidobacterium adolescentis (strain ATCC 15703 / DSM 20083 / NCTC 11814 / E194a)

Length

291 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.278 kDa

Sequence

MGTRIDGKKVAARTKADLAKRVELLKARGIQPGLGTILVGSDPGSVKYVAGKHADCAEIGVNSIKRELPENATFDQVADAVRQLNADPACTGYIVQLPLPRGIDENAIIDLIDPKKDADGMHPYNLGELVLHARGDITTPLPCTPRGVIELLRAYDIDLDGKEVCVLGRGITIGRTIGLLLTRKAVNATVTLCHTGTKDVRDHMRRADVIVAAMGVAGFVKPEDIKEGSILVDVGVSRVFDEESGRYKVKGDVDKACYEKAFAYTPNPGGVGPMTRAMLLQNVVEMAERQL

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Bifidobacterium longum (strain DJO10A)

Length

291 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.931 kDa

Sequence

MSTKIDGKQIAAEIKTNLAERVNKLKAQGIQPGLGTLLVGEDPGSMKYVAGKHADCQEVGITSVKKELPADASFDDIAAAVRELNEDPACTGFIVQLPLPKGINENAIIDMIDPAKDADGMHPYNLGELVLHVRGDISTPLPCTPRGVLELLDAYDIDLNGKEVCVLGRGITIGRTIGLMLTRNAVNATVTLCHTGTRDVADHMRRADVIVAAMGSAGFVTPDKIKDGAVLVDVGVSRVYDEEAGRYRIKGDVDKACYDKASAYTPNPGGVGPMTRAMLLANVVEMAERHA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Bifidobacterium longum subsp. infantis (strain ATCC 15697 / DSM 20088 / JCM 1222 / NCTC 11817 / S12)

Length

291 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.003 kDa

Sequence

MSTKIDGKQIAAEIKTNLAERVNRLKAQGIQPGLGTLLVGEDPGSMKYVAGKHADCQEVGITSVKKELPADASFDDIAATVRELNEDPACTGFIVQLPLPKGINENAIIDMIDPAKDADGMHPYNLGELVLHVRGDISTPLPCTPRGVLELLDAYDIDLNGKEVCVLGRGITIGRTIGLMLTRNAVNATVTLCHTGTRDVADHMRRADVIVAAMGSAGFVTPDKIKDGAVLVDVGISRVYDEEAGRYRIKGDVDKACYDKASAYTPNPGGVGPMTRAMLLANVVEMAERHA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Photorhabdus luminescens subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)

Length

291 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.526 kDa

Sequence

MPAKIIDGKTIAQTIRSEVAVRVQQRVAAGRRAPGLAVVLVGENPASQIYVASKRRACEEVGFVSRSYDLPDTTSEAELLNLIDQLNNDSDIDGILVQLPLPAGIDNVKVLERIQPDKDVDGFHPYNIGRLCQRAPKLRPCTPRGIATLLERCGINTYGLNAVIIGASNIVGRPMSLELLLAGCTTTVTHRFTKDLRHHVEQADLLIVAVGKPNFIPGEWIKPGAIVIDVGINRLEDGKVIGDVDFETASERASWISPVPGGVGPMTVATLIQNTLQACEEYHDVERIEGC

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Halorhodospira halophila (strain DSM 244 / SL1)

Length

290 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.133 kDa

Sequence

MPAQILDGKAIAAKRRALVGEAVGQRIERGLRRPGLAVILVGQNPASAVYVRNKRRACEEAGILSRAYDLDADVSEGELLERIDRLNADPEIDGILVQLPLPGHIDEQTVIERIDPVKDVDGFHPENMGRLALRLPGLRPCTPRGVMTLLHHTGIELEGRDAVVLGQSNIVGRPMTLELLNARCTVTVCHSRTRNVAERVRQADLVVASVGKPGLIQGDWIGEGAVVIDVGINRLDSGKLTGDVDFEAASQRASWITPVPGGVGPMTVATLLENTLDAARNRDELTAAAC

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Helicobacter pylori (strain HPAG1)

Length

290 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.616 kDa

Sequence

MPNRGVVLLDGQALAYDIEKDLKNKIQTITAQTHKRPKLAVILVGKDPASITYVNMKIKACQRVGMDFDLKTLQEDITEAKLLSLIKDYNTDQNISGVLVQLPLPRHIDSKMVLEAIDPSKDVDGFHPLNIGKLCTQKESFLPATPMGVMRLLKHYHIEIKGKDVAIIGASNIIGKPLSMLMLNAGASVSVCHILTKDISFYTQNADIVCVGVGKPDLIKASMLKKGAVVVDIGINHLNDGRIVGDVDFNNAQKVAGFITPVPKGVGPMTIVSLLENTLIAFEKQQRKGF

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Helicobacter pylori (strain J99 / ATCC 700824)

Length

290 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.66 kDa

Sequence

MPNRGVVLLDGQALAYNIEKDLKNKIQIITAQTHKRPKLAVILVGKDPASITYVNMKIKACQRVGMDFDLKTLKENITEAELLSLIKDYNTDQNISGILVQLPLPRSIDTKMILEAIDPNKDVDGFHPLNIGKLCTQKESFLPATPMGVMRLLEHYHIEIKGKDVAIIGASNIIGKPLSMLMLNAGASVSVCHILTKDISFYTKNADIVCVGVGKPDLIKASMLKKGAVVVDIGINHLNDGRIVGDVDFINAQKIAGFITPVPKGVGPMTIVSLLENTLIAFEKQQRKGF

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Helicobacter pylori (strain ATCC 700392 / 26695)

Length

290 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.686 kDa

Sequence

MPNRGVVLLDGQALADNIEKDLKHKIQIITAQTHKRPKLAVILVGKDPASITYVNMKIKACERVGMDFDLKTLQENITEAKLLSLIKDYNTDQNISGVLVQLPLPRHIDTKMILEAIDPNKDVDGFHPLNIGKLCTQKESFLPATPMGVMRLLEHYHIEIKGKDVAIIGASNIIGKPLSMLMLNAGASVSVCHILTKDISFYTQNADIVCVGVGKPDLIKASMLKKGAVVVDIGINHLNDGRIVGDVDFNNVQKVAGFITPVPKGVGPMTIVSLLENTLIAFEKQQRKGF

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Aromatoleum aromaticum (strain EbN1)

Length

290 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.175 kDa

Sequence

MTARILDGNALSARVRGELAERAAALADGGVQPCLAVILVGVNPASAVYVRNKVAACEKAGIRSLRFDFAADVDAAEVMAKIAELNADSAVHGVLVQLPLPKQFNEAEVLEAIRVEKDVDGFHAENVGRLSQGQEAFLPCTPHGVMKMLEAGGVPVQGAEAVVIGRSNIVGKPMAMLLTNAGATVTVTHSKTRDLAFHTRRADILVAAIGKPRFVTGDMIKPGAVVIDVGINRLTEGPDAGKLCGDVDFESAKEVASLITPVPGGVGPMTITMLLANTVESAERVARSKG

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Azorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / JCM 20966 / NBRC 14845 / NCIMB 13405 / ORS 571)

Length

290 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.3 kDa

Sequence

MIETKPIDGKAFAAGLRARIAEEVAVLVRDHDLKPGLAVVLVGEDPASQVYVRNKAAQTAEAGMASFEYKLPADTAEADLLALVEKLNADPAVNGILVQLPLPAHLDSMKVLAAIDPAKDVDGFHVVNAGRLAVGLDALVPCTPLGCVMLLKHHLGNLSGLNAVVVGRSNIVGKPAAQLLLREDCTVTIAHSRTRDLPGMCRQADILVAAVGRPEMVRGDWIKPGATVIDVGINRVPKADGKTRLVGDVAYEEALGVAGLITPVPGGVGPMTIACLLQNTLTAARRQKGL

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Aromatoleum aromaticum (strain EbN1)

Length

290 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.175 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Azorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / JCM 20966 / NBRC 14845 / NCIMB 13405 / ORS 571)

Length

290 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.3 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Gloeobacter violaceus (strain ATCC 29082 / PCC 7421)

Length

290 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.559 kDa

Sequence

MSAAILDGKALAARIQAELTCEVQSLQERFGRPPGLSVLWVGDNPASAAYVRNKNKSGQAVGIDVAKSQHLKASLSETQLLALIDRLNADVTVDGILVQLPLPEHIDSGRVLNRIAPEKDVDGLHPVNLGRLVRGEPGLRSCTPAGVMRILSEAGVPLAGKTAVVIGRSILVGKPVALMLLEKDATVITTHSRTADLAAITQMADVLVVAAGRPELVTAAMVRPGAVVIDVGINRVTDYEGNSRLVGDVDFDSVRDVAAAITPVPRGVGPMTVTMLLANTVQSYKQRLIE

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Proteus mirabilis (strain HI4320)

Length

290 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.386 kDa

Sequence

MSARIIDGKTIAQTIRSEVAEKVKQRIKIGKRAPGLAVILVGDNPASQIYVASKRKACDEVGFISRSYDLPDTTSEADLLNLIDTLNEDNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNIGRLCQRAPKLRPCTPRGIVTLLERCNIPMNGLNAVIIGASNIVGRPMSLELLLAGCTTTVTHRFTKDLRFHVEHADLVVVAVGKPNFIPGEWIKPGAIVIDVGINRLENGKVVGDVDFAQASQRAGWISPVPGGVGPMTVATLIQNTLQACEEYHDPDIGNN

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Cytophaga hutchinsonii (strain ATCC 33406 / NCIMB 9469)

Length

290 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.995 kDa

Sequence

MQLLDGKITSDQIKEELKTKVEAIKAKGGKIPHLAAVLVGDSGAAVTYVNAKVKACELVGFKSTLVKLPETITEADLLAKVAEINADKDIDGYIVQLPLPKHIDEQKVTEAISPDKDVDGFHPTSLGRMVLNLPTYLPATPYGIMQLLERNGIETSGKHCVVMGRSHIVGSPMSILMARNTNPGNATVTMVHSRTKNLKELTLQADILIVAIGKPEFVTADMVKEGAVVVDVGIHRIDDATKKSGFRLLGDVKFDEVAPKTSYISPVPGGVGPMTIASLLMNTLQAAALK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Sodalis glossinidius (strain morsitans)

Length

290 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.983 kDa

Sequence

MVAKIIDGRAVAQQVRSEVAARIQARLKAGKRAPGLAVVLVGGDPASQIYVASKRKACEDVGFISLSYDLPNTVTEAALLALIDQLNADHRVNGILVQLPLPAGIDNISVLERIAPDKDVDGFHPYNVGRLCQRAPLLRPCTPRGIVTLLERYHIDTFGLNAVVVGASNIVGRPMSLELLLAGCTVTVTHRFTRDLRRHIENADLLVVAVGKASFIPGEWIKPGAVVMDVGINRLESGKVVGDVDYASAAERAAYITPVPGGVGPMTVATLIQNTLQACEDYHDTTMPEA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)

Length

290 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.427 kDa

Sequence

MSDESYESRIIDGKVLAQQVEEEVRSGVEDLESNRGIVPGLATILVGDDPASKMYVRLKHRACERVGIKAEDYLLPGDATQEELLTLIDSLNKNKDVHAILLQLPLPKHFSPQETQEAMEAISPTKDADGFHPYNMGKLMIGDEDLVPCTPHGVIRALEEYGVSVQGKNAVIVGHSNVVGKPMAAMLLNRNATVSVCHIFTDDLKKYTLGADIIVVATGVKHLIKADMVKEGTVIFDAGITKEEDGVYGDVDFENVIKKASLVTPVPGGVGPMTIAMLMKHVLLCAEKSL

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Pelobacter carbinolicus (strain DSM 2380 / NBRC 103641 / GraBd1)

Length

290 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.555 kDa

Sequence

MSAQLLEGKVVAAAVLEDVARRVAVLKDKGISPGLGTILVGDDGPSVSYVNKKRETCKQVGIASFHNEIPASATQSDLLAAVRDFNDSPDVDAYIIQYPLPKGFDFNEALNLMLPEKDADGLHPVNLGRLVLQEPGPVPCTPAGIRAMLQHYDIAIEGKEVVVIGRGPTLGRPLSLLLTLKQPYANAAVTVVHSGIKDLGAYTRRADIVIAAAGCPGIVQPDMIRPGAVVISGGISWEGRKLLPDVDEAVGEVAGWITPRLGGVGPTTVAMLLLNTVQAAEERARRAGKL

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Ralstonia pickettii (strain 12J)

Length

289 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.291 kDa

Sequence

MTAQLIDGNALAKQLRAEAAQRAAALTARGHQPGLAVILVGEDPASQVYVRNKIKACEDNGFLSSFDRYPADLSEADLLGRIDALNRDPRIHGILVQLPLPKHIDSHKVLEAIAPEKDVDGFHVANAGALMTGAPLFRPCTPYGCMKMLESINYPVRGANAVVVGASNIVGKPMAMLLLQSGATITICNSKTRDLAAHTREADIIVAAVGRRNIITADMVKPGAVVIDVGMNRDDAGKLCGDVDFAGVKEVAGYITPVPGGVGPMTITMLLINTLEAAERAAEGAALAA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Ralstonia solanacearum (strain GMI1000)

Length

289 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.392 kDa

Sequence

MTAQLIDGNALAKQLRTEAAQRAAALTARGHQPGLAVILVGDDPASQVYVRNKIKACEDNGFLSIFDRYPADLTEADLLGRIDALNRDPRIHGILVQLPLPKHIDSHKVLEAIAPEKDVDGFHVANAGALMTGAPLFRPCTPYGCMKMLESIDYPVRGARAVVVGASNIVGKPMAMLLLQAGATVTICNSKTRDLAAHTREADIVVAAVGRRNIITADMVKPGAVVIDVGMNRDDAGKLCGDVDFAGVRDVAGHITPVPGGVGPMTITMLLINTLEAAERAAEDAALAA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Cyanothece sp. (strain ATCC 51142)

Length

289 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.864 kDa

Sequence

MSSETASLLNGKALAQKIQGELKTTVEKLQGNIGRPPGLAVIMVGDNPASAVYVRNKEKACAKVGIASFGRHLPTETPQEEVEALIHQLNADERVDGILVQLPLPPHLDTVKLLHAIAPEKDADGLHPMNLGHLIRGEEGLRSCTPWGVMRLLEEYNLDVAGKHAVVVGRSILVGKPLALMLLEKNATVSIAHSRTPDLGEITRQGDIIIAAVGKPNLITGEMVKPEAIAIDVGINRIMTKDGASKLVGDFEFNSVSQVSSYITPVPGGVGPMTVAMLLQNTVLSYQKH

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Cyanothece sp. (strain ATCC 51142)

Length

289 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.864 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Methylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875)

Length

289 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.685 kDa

Sequence

MTAQIINGKAIAEATLSETKSLIDKRLEKGLRAPTLAVILLGSDPASTIYVRNKRLACDKTGIRSLAYDLPDTTSEAELLALIKQLNQDDAVDGILVQSPLPAHIEEKKIIETISATKDVDGFHPYNIGRLAVRQPTLRSCTPYGVIKLLQSTGVRLLGLDAVVVGVSNHVGRPMALELLLAGCTVTSCHRHTKDLQASIARADIVVAAVGKPHLIKGEWIKPGAIVIDIGINRLADGSLCGDVEFDIAKTRAAWITPVPGGVGPMTVATLMQNTLTALELGESDQAPA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Synechococcus elongatus (strain PCC 7942)

Length

289 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.599 kDa

Sequence

MAAAILDGRALAAQRRQQLREQVEAIAPAVGRRPGLAVIMVGDNPASAVYVRNKERACEQTGIVSFGKHLPGDSSEAEIRALIEELNQDDRVDGILVQLPLPSHLDAVPLLLAIDPEKDADGLHPLNLGRLLRGEEGLRSCTPAGVMELLAANQIDPAGKKAVVIGRSILVGKPLAMMLLEANATVTIAHSRTPNLPEVCRQADIVVAAVGRPELVGADWIKPGAVVVDVGINRLEDGRLVGDVDYEAASAITSWITPVPGGVGPMTVAMLLHNTVLSYCRRSGQPFLS

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Synechococcus sp. (strain JA-3-3Ab)

Length

289 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.469 kDa

Sequence

MSAKILDGKALAGRLQAEMAAQVQAWLPRVGRPPGLAVLRVGEDPASAAYVRGKERACERVGIASFGRHFSAQDSPAHLLDAIAQLNQDERVDGILVQLPLPPGWDPIPPLLAIDPAKDVDGLHPLNLGRLVRGEPGLRSCTPLGVMRLLQAEGIPIAGRKAVVVGRSLLVGKPLSLMLLAADATVTVAHSRTPNLAEVTRSADIVVMAVGRPRLLTADMVKPGAVVVDVGINRIQDPDGSEQLVGDVDYEAVKERAAAITPVPGGVGPMTVTMLLANTLESYKLRSHL

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Synechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1)

Length

289 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.599 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Cronobacter sakazakii (strain ATCC BAA-894)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.824 kDa

Sequence

MAAKIIDGKTIAQQVRLEVAEKVKARVAAGKRAPGLAVVLVGANPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELLALIDELNADAAIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRQHVENADLLIVAVGKPGFIPGEWIKEGAIVIDVGINRLENGKVVGDVVFEEAAKRASYITPVPGGVGPMTVATLIQNTLQACVEYHDGEEA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Mycoplasma mycoides subsp. mycoides SC (strain PG1)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

32.102 kDa

Sequence

MVILDGKLVSKQIKQTLKKQIDTYLNKNYKKPKLAVILIGNDPASELYVSNKIKACNLVGIESVLLRFGQNITSEMLSDQINQLNNDNSVDAILLQLPLPKHLDEQEFLQAIDPLKDVDGFHYINQGKMLEGYDTIYPCTPIGIINLLKAYNIDVRSKDITIIGTSNIVGKPLAIMLSNMGATISMCNKNTKSLKKYTKRSDIVISTTGKQALIKKDMIKKNAIVIDVGIIKDPITNKIVGDVDFENVKELCSYITPVPGGVGPMTVSMLLENTFKLYKLHIKENYEN

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Mycobacterium sp. (strain JLS)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.414 kDa

Sequence

MSGVGAITLDGKATRDEIFVDLKERVAALTEQGRTPGLGTVLVGDDPGSQAYVRGKHSDCAKVGINSIRRDLPADISQAELDATIDELNANPECTGYIVQLPLPKHLDENAALERIDPGKDADGLHPTNLGRLVLNEPAPLPCTPRGIVHLLRRYEVEIAGAHVVVIGRGVTVGRPLGLLLTRRSENATVTLCHTATRHLPQFTREADIIVAAAGVPHMVTAEMVRPGAAVIDVGVSRDDNGKLVGDVAPDVWEVAGHVSPNPGGVGPLTRAFLLTNVVERAEALARG

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.956 kDa

Sequence

MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDLPETTSEAELLELIDALNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQGE

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Shigella boydii serotype 4 (strain Sb227)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.956 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Shigella dysenteriae serotype 1 (strain Sd197)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.995 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Shigella flexneri serotype 5b (strain 8401)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.956 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Shigella flexneri

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.956 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Shigella sonnei (strain Ss046)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.956 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Cronobacter sakazakii (strain ATCC BAA-894)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.824 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Mycoplasma mycoides subsp. mycoides SC (strain PG1)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

32.102 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Mycobacterium sp. (strain JLS)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.414 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.956 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Shigella boydii serotype 4 (strain Sb227)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.956 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Shigella dysenteriae serotype 1 (strain Sd197)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.995 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Shigella flexneri serotype 5b (strain 8401)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.956 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Shigella flexneri

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.956 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Shigella sonnei (strain Ss046)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.956 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Escherichia coli O139:H28 (strain E24377A / ETEC)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.014 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Escherichia coli O127:H6 (strain E2348/69 / EPEC)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.956 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Escherichia coli O45:K1 (strain S88 / ExPEC)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.956 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Escherichia coli (strain 55989 / EAEC)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.014 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Escherichia coli O157:H7

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.956 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Escherichia coli O157:H7 (strain EC4115 / EHEC)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.956 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Escherichia coli O7:K1 (strain IAI39 / ExPEC)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.986 kDa

Sequence

MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQGE

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Escherichia coli O81 (strain ED1a)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.956 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Escherichia coli O8 (strain IAI1)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.044 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Escherichia coli (strain K12 / MC4100 / BW2952)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.044 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Escherichia coli (strain K12 / DH10B)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.044 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Escherichia coli O9:H4 (strain HS)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.956 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Escherichia coli O1:K1 / APEC

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.956 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Escherichia coli O6:K15:H31 (strain 536 / UPEC)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.956 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.956 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Mycobacterium sp. (strain KMS)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.414 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.435 kDa

Sequence

MMRVGAITLDGKATRDEIFVDLKERVTALTAAGRTPGLGTVLVGDDPGSQAYVRGKHADCAKVGIESIRRDLPADISQETLLETLDELNANPACTGYIVQLPLPKHLNENAALERIDPGKDADGLHPMNLGRLVLNEPAALPCTPRGIVHLLRRYQVEIAGAHVVVIGRGVTVGRPLGLLLTRRSENATVTLCHTATRHLPQITREADIIIAAAGVPHMVTAEMVRPGAAVVDVGVSRDEAGKLVGDVHPDVWEVAGHVSPNPGGVGPLTRAFLLTNVVERAEALAGS

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Thermomicrobium roseum (strain ATCC 27502 / DSM 5159 / P-2)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.631 kDa

Sequence

MAAHILSGRPVVESLHARIQQVLARRAPHQGPPTLTVLLPNDPSAQAYARAIRKQFTTLSLNYRTEEIDDTLDESRFAILLKRLAEDESVTGILALQPLPKGVSRRSLARLMPPTKDVDGVSFEQQGRLAIGSPWIAPSTPLGGLILLQHYGIEVAGRHAVVIGRSPVVGRPLALLLLARDATVTICHRRTPDLAKLTRQADLLFVAAGQPHLVKPDMVAPGAVVIDFGVSVRDGRLIGDVDPAVAEVASALTPVPGGTGPVTTAVLALNLLRLAGLLEENDLFPGAP

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Desulfovibrio vulgaris (strain Miyazaki F / DSM 19637)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.175 kDa

Sequence

MLLLDGKATAAAIRAELKEEVAAGLAAAGRAPGLAVILVGEDPASQVYVRNKERGCEEAGIRSEAFRLPADTTQETLEVLIDELNGRADIDGILLQLPLPKGLNSQRCLERISPRKDVDGFHPENMGRLALGLPGFRPCTPAGVMTLLERYDLSPSGKKAVVVGRSNIVGKPLALMLGAPGKYANATVTVCHSGTPDLAEECRQADFLFVAAGRPCLVTSDMVKPGAVVVDVGIHRTDEGLVGDCKYDDISCIAAAMTPVPGGVGPMTIAQLLINTVISWKGRTGIAG

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Nitrosospira multiformis (strain ATCC 25196 / NCIMB 11849 / C 71)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.691 kDa

Sequence

MSAKIIDGKRLSQEVRAECRARAARLAEKGTQPGLAVVIVGDNPASRVYVRNKAKACGETGIYSEVHEFPENANQDEVIGRIQELNGNPGIHGILVQLPLPRHFDSSRVTESVAVEKDVDGFHLYNVGALVTGSSIFPPCTPNGVMKMLEKYDIPIEGQHAVIVGRSNIVGKPMALMLLQKGATVTICTSRTRNLAEHTSRADILIVAAGKPRLITAMMVKPGATVIDVGINRLSDGKLAGDVDFESVKEKAGYITPVPGGVGPMTIAMLLCNTVVAAEQAHARLQGN

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Acidithiobacillus ferrooxidans (strain ATCC 23270 / DSM 14882 / CIP 104768 / NCIMB 8455)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.372 kDa

Sequence

MTARRIDGKAIAQKIHADISLRSHAFLRQWGRSPGLAVVLVGADPASRIYVQKKRETCASVGIASFSANLPADTNPQQLLAHIGELNVNDAVDGILVQLPLPPHFDPEEIIEAIAVEKDVDGFHPYNIGRLALRAPLLRSCTPAGIMTLLQESGIDIKGKEAVIVGASNIVGRPMALELLLAGATVTVCHRFTRDLAAHVGRAELLVAAAGKPGLISGAWIREGAVVIDVGINRLPDGRVTGDVDFAGAEQRAAWITPVPGGVGPMTVATLLQNTLIAAEHRMGAPHV

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Acidithiobacillus ferrooxidans (strain ATCC 53993)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.372 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Rickettsia africae (strain ESF-5)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.995 kDa

Sequence

MNNIIDGKALANEILADLKLEIQELTSQTNASPKLAIVLVGDNPASIIYVRHKIKNAHKIGIYTLLINLSATIHTNDLISKINELNLDNEISGIIVQLPLPSSIDKNKILSAVSPSKDIDGFHPLNVGYLHSGISQGFIPCTALGCLAAIKKYEPNLTGKNVVIIGRSNIVGKPLSALLLKENCSVTICHSKTHNLRSITSKADIVVAAIGSPLKLTAEYFNPKSIVIDVGINRISSNKIIGDVDFENVQSKVQYITPVPGGIGPMTIAFLLKNTVKAFKDSLYTLDT

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.983 kDa

Sequence

MSAKIIDGKTIAQQVRNEVAAVVQQRLAAGKRAPGLAVVLVGENPASQIYVASKRKACEEVGFVSRSYDLPMATSEAELLALIDSLNEDTEIDGILIQLPLPNGIDNVKVLERIHPDKDVDGFHPYNVGRLCQRAPKLRACTPRGIMTLLERYDIPTYGLNAVVVGASNIVGRPMSLELLLAGCTTTVTHRFTKNLRHHIENADLLVVAVGKPGFIPGEWIKPGAIVIDVGINRLESGKVVGDVAFDVAAERAGWITPVPGGVGPMTVATLIQNTLQACEEYHDISQN

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Yersinia pestis bv. Antiqua (strain Antiqua)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.983 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Yersinia pseudotuberculosis serotype IB (strain PB1/+)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.983 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Yersinia pestis

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.983 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Yersinia pestis bv. Antiqua (strain Angola)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.983 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Yersinia pestis bv. Antiqua (strain Nepal516)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.983 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Yersinia pestis (strain Pestoides F)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.983 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Yersinia pseudotuberculosis serotype I (strain IP32953)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.983 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Yersinia pseudotuberculosis serotype O:3 (strain YPIII)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.983 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Klebsiella pneumoniae (strain 342)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.974 kDa

Sequence

MAAKIIDGKTIAQQVRSEVAEKVKARVAAGKRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELLELIDTLNADKTIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLESGKVVGDVVYEDAAERASYITPVPGGVGPMTVATLIQNTLQACEEYHDVEEA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.974 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Lactobacillus brevis (strain ATCC 367 / JCM 1170)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.611 kDa

Sequence

MTTIIDGKQIAKDLNAQTATRVAALKKRDIVPGLAVIVVGDDPASAIYVRNKHKKALKLGIKSVVRELPATTTQAELTQIVMAYNVDPTIHGILVQSPLPAGLDEQAIVAAIDPQKDVDGFHPLNVGRLFANLPGKYPVSCTPRGIMTMLATLPMHLRGKRAVVVGRSLIVGRPMAAMLLNADMTVSVAHVHTQHLSDLTRTADVLVVATGVTHLIKATDVKPGAVVIDVGMDRDENGKLTGDVDFDNVAPRVAAITPVPGGVGPMTIATLMQQTVDLCEWSEQRGNN

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Campylobacter curvus (strain 525.92)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.246 kDa

Sequence

MKILDGKATSAKVKAEVKERASALKNAGIEPALAVILVGSDKASQTYVAAKQKACEASGIRSVMHKLPQTTSQNELLALINVLNLDDSIDGILVQLPLPAHIDTTSVLETIWPQKDVDGFHAENVGKLVSGLDGFVPCTPLGIMRILKEYGIDVAGLNAVVIGRSNIVGKPMASLLLNASATVTITHSKTRNLKQICSAADLIVAAIGKPNFVTADMVKEGAIVIDVGINRLDDGRLVGDVDFEAVAPKSSFITPVPGGVGPMTIAMLLSNTIRSAQNRAKNLGIVKE

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Rickettsia canadensis (strain McKiel)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.082 kDa

Sequence

MNNIIDGKALANEILADLKLEIQELKDKTNTSPKLAIVLVGNNPASIIYVKHKIKNAHNIGIDTLLVNLSTNIHTDDLILKINELNLNNEISGIIVQLPLPRSIDTNKILSAVLPLKDIDGFHPLNVGYLHSGISQGFIPCTALGCLAVIKKYETNLSGKNVVIIGRSNIVGKPLSALLLKEHCSVTICHSKSQNLSKISSKADIVIAAIGSPVKLTAEYFNPESIVIDVGINRINGNKIIGDVDFENVKSKVKYITPVPGGIGPMTIAFLLNNTVKAFKDSYSTVCH

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Rickettsia conorii (strain ATCC VR-613 / Malish 7)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.995 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Rickettsia massiliae (strain Mtu5)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.043 kDa

Sequence

MNNIIDGKALANEILADLKLEIQELISQTNASPKLAIVLVGDNPASIIYVRNKIKNAHKIGIYTLLVNLSTTIHTNDLISKINELNLDNKISGIIVQLPLPSSIDKNKILSAVSPSKDIDGFHPLNVGYLHSGISQNFIPCTALGCLAVIKKYEPNLTGKNVVIIGRSNIVGKPLSALLLKENCSVTICHSKTHNLSSITSKTDIVVAAIGSPLKLTAEYFNPESIVIDVGINRISGNKIIGDVDFENVQSKVKYITPVPGGIGPMTIAFLLKNTVKAFKDSLYTLDK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Rickettsia peacockii (strain Rustic)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.982 kDa

Sequence

MNNIIDGKALANEILADLKLEIQELTSHTNASPKLAIVLVGDNPASIIYVRNKIKNAHKIGIYTVLINLSATIHTNDLISKINELNLDNEISGIIVQLPLPSSIDKNKILSAVSPSKDIDGFHPLNVGYLHSGISQGFIPCTALGCLAAIKKYEPNLTGKNVVIIGRSNIVGKPLSALLLKENCSVTICHSKTHNLRSITSKADIVVAAIGSPLKLTAEYFNPESIVIDVGINRISSNKIIGDVDFENVQSKVQYITPIPGGIGPMTIAFLLKNTVKAFKDSLYTLDT

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Rickettsia rickettsii (strain Iowa)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.996 kDa

Sequence

MNNIIDGKALANEILADLKLEIQELTSQTNASPKLAIVLVGDNPASIIYVRHKIKNAHKVGIYTLLINLSATIHTNDLISKINELNLDNEISGIIVQLPLPSSIDKNKILSAISPSKDIDGFHPLNVGYLHSGISQGFIPCTALGCLAAIKKYEPNLTGKNVVIIGRSNIVGKPLSALLLKENCSVTICHSKTHNLRSITSKADIVVAAIGSPLKLTAEYFNPESIVIDVGINRISSNKIIGDVDFENVQSKVQYITPVPGGIGPMTIAFLLKNTVKAFKDSLYTLDT

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Rickettsia rickettsii (strain Sheila Smith)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.996 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Roseiflexus castenholzii (strain DSM 13941 / HLO8)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.294 kDa

Sequence

MTAMILDGRALAKTLREELRADIQAFVQTTGVTPSLAVVKIAGDPASERYTRTIRKGCEDIGIVFYDHTLPPDTTQAALEETLHALSFDRAVNGILLHLPLPPGFDSNRAIAQIDPHKDVDGVHPYNAGLLAMGQPTMVPNTPAGGMELLLRNHILIKGQRATVVGRSVVVGKPMALLLLQEHATVTIAHSRTKDLASVVREADIVVAATGKPGLITADMVRPGAVVVDFGVNVLGDGKVVGDVDFAGVAEIASAITPVPGGTGPVTNIMLLRNVLRAARLQGVGRGE

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Roseiflexus sp. (strain RS-1)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.276 kDa

Sequence

MTAIILDGRALAKTLREELRADTQAFIQNNGIAPSLAVVKIAGDPASDRYTRTIRKGCEEIGITFTDHTLPPETTQAMLEETISALSFDRTIHGILLHLPLPPGLDSARAIAQIDPAKDVDGVHPYNAGLLAMGRPGLIPNTPAGGMELLLRNNIPLKGQHATVVGRSVVVGKPMALLLLNEHATVTIAHSRTKDLAAVVRSADIVVAATGKPGLITGDMVKPGAVVVDFGVNVLEDGRVVGDVDFDSVVNVASAITPVPGGTGPVTNVMLLRNVLRAAQQQLASRHH

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Salmonella agona (strain SL483)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.844 kDa

Sequence

MAAKIIDGKTIAQQVRSEVAQKVQARVAAGLRAPGLAVVLVGSNPASQIYVASKRKACDEVGFVSRSYDLPETTSEAELLALIDTLNADNTIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKDLRHHVEHADLLIVAVGKPGFIPGEWIKEGAIVIDVGINRLENGKVVGDVVFDEAAARASYITPVPGGVGPMTVATLIENTLQACIEYHDPQGK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.877 kDa

Sequence

MAAKIIDGKTIAQQVRSEVAQKVQARVAAGLRAPGLAVVLVGSNPASQIYVASKRKACDEVGFVSRSYDLPETTSEAELLELIDTLNADSTIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKDLRHHVEHADLLIVAVGKPGFIPGEWIKEGAIVIDVGINRLENGKVVGDVVFEEAAARASYITPVPGGVGPMTVATLIENTLQACTEYHDPQGK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Salmonella choleraesuis (strain SC-B67)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.844 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Salmonella dublin (strain CT_02021853)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.844 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Bdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIB 9529 / HD100)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.891 kDa

Sequence

MVLILDGKEVAKEVRASLVPRVAKFKETYGRAPQLSVVIVGDDKASHVYVKNKKIACEKIGMTSTIHTLPAETTQSELNQILSKLNNDNGVDGILVQFPLPKHLSSDEVLKLVSAEKDADGLTYESLGYFFAGKPLVSPCTPAGVMEILKHYRIPVEGKKAVVVGRSNIVGKPMALLLTEANATVTLCHSKTSNMSELTKQADLVVVAAGKARLLGKEDFKKDAIVIDVGMHGSGQGGKLCGDVRFEELDGWAKAATPVPGGVGPMTIAMLLKNTCQLAEQRARDPQF

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.044 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Escherichia coli (strain K12)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate. This enzyme is specific for NADP.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.044 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.986 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Escherichia coli (strain SE11)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.014 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Escherichia coli (strain SMS-3-5 / SECEC)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.986 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Escherichia coli (strain UTI89 / UPEC)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.956 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Elusimicrobium minutum (strain Pei191)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.985 kDa

Sequence

MILEGKTLAAAIRENLPARAQICKTKLGRPLKLTGIGWAADYASYVYLDKEIKAAEKTGITGEVIDITEQTSHEEMLNIIKKLSTDETVDAVIVPKPLPRHLNTLEIWEALNPLKDIDGSSVLNMGRLFMCKNWAEVEAMQGFAPATAMAVIKLLDFYKIKLSGVETGVLGRSATVGKPLAHMLSCKDATVKICHSKTPSLTSSLSQCDIVISAIGKAKFVTENMVKTGAMVIDVGTNQDENGVFCGDVDFENVKKITSAITPVPGGVGPVTLACLLENIIISGERKL

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Enterobacter sp. (strain 638)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.919 kDa

Sequence

MAAKIIDGKTIAQQVRSEVAVKVKARTAAGKRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTTEAELLELIDTLNADEVIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRQHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLENGKVVGDVVYEDAAARASYITPVPGGVGPMTVATLIQNTLQACEEYHDVEEA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Erwinia tasmaniensis (strain DSM 17950 / CIP 109463 / Et1/99)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.718 kDa

Sequence

MVAKIIDGKTIAQQVRNEVAGLVQQRLAAGKRAPGLAVVLVGENPASQIYVSSKRRACEEVGFLSRSYDLPASTSEAQLLELITQLNDDAEIDGILVQLPLPAGIDNTKVLEHISPAKDVDGFHPYNVGRLCQRAPTLRPCTPRGIVTLLERYQIDTFGLNAVVVGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRQHIENADLLVVAVGKPGFIPGDWIKPGAIVIDVGINRLESGKVVGDVDFDLASTRASWITPVPGGVGPMTVATLIQNTLQACENNDNGVSA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73)

Length

288 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.028 kDa

Sequence

MAAKIIDGKTIAQQVRSEVAQKVQARVAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDLPETTSEAELLELIDVLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQDE

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)

Length

287 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

32.044 kDa

Sequence

MLKKVLNGTRIAKKLEFKILKQVNYKLSLGQRPPGLAVILIGSNSASTIYVKKKRFMCEQVGFISKFWKFSKNIQESKILNLIYKLNYDTTIDGILVQLPIPPNINNQKLFSSIIPTKDVDGFHPYNIGSLCQKSPYLRPCTPFGIITMLKHYKIKIRGLHAVVIGASNIVGRPMSMELLLAGCTTTITHRFTKNLKHYVKQADLIVIAIGHAHFLKGTWIKKGAIVIDVGINRLKNGEIVGDVDFKTAYKKSSYITPVPGGVGPMTVITLLNNTLKAYEQISKDCK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Haemophilus ducreyi (strain 35000HP / ATCC 700724)

Length

287 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.083 kDa

Sequence

MAAKIISGINIAKQIKQNIAQKIAQYIVNGYRRPGLAVILVGADPASQVYVNSKRKSCAEIGIESKYYDLPATITEVELLSIIQRLNSDEMIDGILVQLPLPEHINPIHITEAISSDKDVDGFHPYNVGRLCQKIPTLRSCTSYGVMKLLESTHIDLSGLHAVIVGASNIVGRPMAMELLLAGCTVTITHSRTKNLVDHLSSADIVIVGIGHPNFVKGEWLKQGAIVIDVGINRDTYSKKLVGDVDFLTAEAKASFITPVPGGVGPMTVAMLMQNTLQAYEHHLQAV

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Heliobacterium modesticaldum (strain ATCC 51547 / Ice1)

Length

287 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.015 kDa

Sequence

MTAQYIDGKAIAAQLRAEIKAEVASLREQGIVPKLAVILVGDDPASVVYARSKEKAAANLGIAFELFTLPGDTTEAALLALIERLNADAAVHGIMVELPLPKQISKEKVLEAIHPLKDVDGVHPLNRGYLMAGQPGLVPATPMSCMELLARSGVELAGKRVVIIGRGETVGKPLFFLLLRRNATVTVCHTRTKDLAAEVRRAEIVIAAAGKAGLVTGEMIAPDAVVIDAGINEGEDGNIVGDVKTAEAAERASLISPVPGGVGACTTALLFRNVLFGLKLQGGMAHE

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Arcobacter butzleri (strain RM4018)

Length

287 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.924 kDa

Sequence

MILLDGKALSEKIKAEVKLEVEEIVKEKEITPGLAVILVGNDPASATYVASKAKSCENAGIYSVVHKMPETITQEELLQTIAMMNKNPKLDGILVQLPLPKQIDTTVVLEAIDPLKDVDGFHPYNVGRMVSNLDAFLPATPFGVMRMFEEYGIELSGKNVVVIGSSDIVGKPMASLLINAKATVTVCNSRTKDLKAHTLAADIVVIAVGVPFLLKEDMVKDGAIVIDVGINRLDTGKLVGDADFEGLKNKCSFLTPVPGGVGPMTIAMLLKNTIKASKLREKRENRC

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Cutibacterium acnes (strain DSM 16379 / KPA171202)

Length

287 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.297 kDa

Sequence

MTAQKLDGKATAAAIKSELAERVAALRDQGVVPGLGTVLVGEDPASHQYVAGKHRDCAQVGIESIRVDLPADVTEEELAQKIRGLNANPHCTGYIVQLPLPRHIDTNWALNLIDPNKDADGLTPASLGRLVLNEPAPLPCTPRGIVELLTRHGIELPGANVCVVGRGTTVGRPLGLLLTRRSENCTVTLCHTGTRNLAEHTRQADIIIGAAGSPGLINADMIREGAVLVDVGVSRTPEGKIQGDFTADVWEKAAWVSPNPGGVGPMTRAMLLSNVVDRAERLTADPS

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Arcobacter butzleri (strain RM4018)

Length

287 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.924 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Cutibacterium acnes (strain DSM 16379 / KPA171202)

Length

287 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.297 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Trichodesmium erythraeum (strain IMS101)

Length

287 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.882 kDa

Sequence

MTNKLDGKALAKKIKAELQQKVQSLQIKIGRPPGLAVLMVGDNPASGVYVRNKEKACTQVGITSLGKHFPTQTSQAQLGQVIQKLNQDPQVDGILVQLPLPKHLDSTSLLYQIDPSKDVDGLHPMNLGQLLRGEKGLRSCTPAGVMRLLQEYKIELQGKHAVILGRSILVGKPMALMLLEANSTVTIAHSRSKNLEAITKKADILITAVGRPKMISAEMVKPGAVVIDVGINRVIDEAGNSQLVGDVQFNSVAQVAEYITPVPGGIGPMTVAMLLQNTVERWSTLVE

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Nitrosopumilus maritimus (strain SCM1)

Length

287 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.956 kDa

Sequence

MTGTKIDGKVISQSVKDRVKKAVEELKNQGINPCLATVLVGDNPASATYVRNKHRACEEVGITTKDHKLDASTTQAQLNEIIENLNNDNSVHGILVQLPLPEQLDEFTTTSRISPLKDVDGLTPHNAGLLAMKKAALVACTPSGVMEMFDYHGIELEGKNIVLINRSNLVGKPLYHLLLDKNATVITCHSRTKNLVELCQSADIIITAVGDRNKFTLTSDMIKEGAIVIDVAISRFQEKLVGDADYEDIIQKASFATPVPGGVGPMTVAMLLKNTITAASLSSQIGK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Sorangium cellulosum (strain So ce56)

Length

287 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.972 kDa

Sequence

MAAKILDGKAIAQKVRDEVREGVARFVAAHGRPPGLEVVLVGEDPASVTHTRSKERMSNEVGIRGRLRALPAATTEAELLACVAELDADDTVDGILVQLPLPARIRAHAVLDAIDPAKDVDGLHPVNAGLLAMGRPGGIAPCTPVGCMRLLAEAGVELAGARAVVVGRSNLVGRPMAQLLLARHATVAIAHTRTRDLKALCREADVLVVAAGKAKLIGGDWIKEGATVIDVGMNRDDAGKLVGDVDFDAVRERAAWITPVPGGVGPMTIASLLETTLRAAEARVAKR

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / JCM 1027 / KCTC 2358 / NCIMB 9240)

Length

287 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.797 kDa

Sequence

MSAKIIDGKQVAQTIRNQVAAQVQQRLAQGKRAPGLAVILVGVDPASQVYVGSKRRACEEVGFISRSYDLDATASQEELLALIDKLNEDADVDGILVQLPLPAHCDTTQVLERIRPDKDVDGFHPYNVGRLAQRIPALRPCTPKGIMTLIEATGVKTHGLHAVVVGASNIVGRPMTLELLLAGCTTTTCHRFTQDLEDQVRRADLLVVAVGKPNFIPGEWIKPGALVIDVGINRLADGSLVGDVEFETARNHASFITPVPGGVGPMTVASLMENTLSACQDYHDNAQ

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Aeromonas salmonicida (strain A449)

Length

287 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.811 kDa

Sequence

MSAKIIDGKQVAQTIRNQVAAQVQQRLAQGKRAPGLAVILVGVDPASQVYVGSKRRACEEVGFISRSYDLSATASQEELLALIDRLNDDADVDGILVQLPLPAHCDTTQVLERIRPDKDVDGFHPYNVGRLAQRIPALRPCTPKGIMTLIETTGVKTHGLHAVVVGASNIVGRPMTLELLLAGCTTTTCHRFTQDLEQQVRRADLLVVAVGKPNFIPGEWVKPGALVIDVGINRLADGSLVGDVEFETARNHASFITPVPGGVGPMTVASLMENTLSACQDYHDQAL

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Methanosarcina barkeri (strain Fusaro / DSM 804)

Length

287 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.051 kDa

Sequence

MLDEGYESRIIDGKVLAKKIEDEVRSGVEALVSGRGITPGLATVLVGDDPASKMYVRLKHRACERVGIQAEDHFLPAETSQEELISLINTLNKDQNVHGILLQLPLPKHLFPQEAMEAIAPEKDADGFHPYNMGKLMIGDEGLVPCTPHGVIRALEEYNVPVKGKNVVIVGHSNVVGKPLAAMFLNRNATVSVCHVFTDDLKKYTLDADILVVATGVKHLIKADMVKEGAVIFDVGITKEKDGVYGDVDFENVIKKAALITPVPGGVGPLTVAMLMKHVLGCAETNY

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)

Length

287 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.015 kDa

Sequence

MLDESYESRIIDGKVLAQQVEEEVRSGVEDLESNRGITPGLATILVGDDPASKMYVRLKHRACERVGIRAEDFLLPADSTQEELLALIDSLNNNKDVHGILLQLPLPEHFSPQEAMEAISPAKDADGFHPYNMGKLMIGDEGLVPCTPHGVIRALEEYNVPVKGKNAVIVGHSNVVGKPMAAMLLNRNASVSVCHIFTDDLKKYTLGADILVVAAGVKHLIKADMVKEGAVIFDVGITKEEDGVYGDVDFENVIKKASLITPVPGGVGPLTVAMLMKHVLMCAEKSL

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Rhodoferax ferrireducens (strain ATCC BAA-621 / DSM 15236 / T118)

Length

287 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.16 kDa

Sequence

MTTQKFGQIIDGVALSAKLRADVATRVLALKARGVTPGLAVILVGEDPASAVYVRNKVKACQDTGVRSVFEKYEATLSEADLLARIAALNADPSIHGILVQMPIPKHINPHKVIEAISVTKDVDGYATLSAGELMTGAPGFRPCTPYGCMKLIETTGIDLRGKHAVVIGRSNTVGKPMALLLLQANATVTVCHSATRDIGYHTRQADVIVAAVGKRNVLTADMVKPGAVVIDVGMNRNDEGKLCGDVDFAGVKEVAGFITPVPGGVGPMTITMLLVNTLEAAERTVK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Carboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 / Z-2901)

Length

287 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.063 kDa

Sequence

MAERLTGKPVADAIKEELKGRVADLKAKGIVPKLGIVRVGARPDDLYYEGGAKKTCESIGMDYEVFEYPQDIDQESFEKAIIEIGAKKDIHGILMFSPLPKHLNERKIRSLIPVEKDVDSLTLGSAGKVFADDPTGFPPCTPTAVMEILKYYNIPLEGKRAVVLGRSLVVGKPAAILLLRENATVTICHSRTKNLPDVCREADILVAAVGRAKMVKEDYVKPGMVVIDVGINEDPDNPGKYCGDVDFDKVEPIVDKITPVPGGVGSVTTAVLCKHTVKACEILNGLV

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Chlamydia abortus (strain DSM 27085 / S26/3)

Length

287 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.695 kDa

Sequence

MLLKGTPVAERVLEKIKQEISHSSTPPGLAVVLIGNDPASEVYVGMKVKKATDLGMVSKAHRLPSDATLTDILKLIERLNNDPTIHGILVQIPLPKHLDSHAIIQAISPEKDVDGLHPVNMGKLLLGQLGGFAPCTPAGIIELLHYYEIPLLGRHVAVVGRSNIVGKPLAAMLMQKHPSTNATVTLLHSQSQNLKEILKTADIIIAAVGVPLFIKESMVSSHAVIIDVGTSRVATNNAKGYILVGDVDFNNVVTKCKAISPVPGGVGPMTVAMLMKNTWESYQKFSS

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672)

Length

287 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.018 kDa

Sequence

MAAKIIDGKTIAQQVKDEVAARVTQRLAEGKRAPGLAVVLVGDNPASQIYVTSKRKVCEEVGFISRSYDLPITTTESELLALIDQLNADQAIDGILVQLPLPEGIDNTKVIERIAPDKDVDGFHPYNVGRLCQRAPLLRACTPRGIITLLERYNIDTFGLNAVVVGASNIVGRPMSLELLLAGCTTTVTHRFTKNLRHHIENADLLVVAVGKPGFIPGEWIKPGAIVLDVGINRLESGKVVGDIEFETAQERASYISPVPGGVGPMTVATLIQNTLQACEEYHDHAE

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Pectobacterium carotovorum subsp. carotovorum (strain PC1)

Length

287 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.892 kDa

Sequence

MAAKIIDGKTIAQQVKDEVAARVTQRLAAGKRAPGLAVVLVGENPASQIYVSSKRKVCEEVGFISRSYDLPATTTESELLTLIDQLNADQAIDGILVQLPLPEGIDNTKVIERIAPSKDVDGFHPYNVGRLCQRAPLLRACTPRGIVTLLERYNIDTFGLNAVVVGASNIVGRPMSLELLLAGCTTTVTHRFTKNLRHHIENADLLVVAVGKPGFIPGEWIKPGAIVLDVGINRLESGKVVGDVEFETAQERASYISPVPGGVGPMTVATLIQNTLQACEEYHDHAE

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Peptoclostridium difficile (strain 630)

Length

287 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.913 kDa

Sequence

MSTKGQIIKGKPVADKISEELIKEVDLLVKEGINPKLTIVRVGARSDDLSYERGALKRCQNIGITTEVLELAEDITQEEYIDVLKRVNDDKNVNGILCFRPLPKHLNEEVIKYVIAPEKDVDCFSPINSAKVMEGDKSGFPPCTPTAVVEILKHYNVDLKGSKVTVLGRSMVVGKPVSMLLLSEHATVTICHSKTKNLSGVAAEADVLIAAIGRAKMVDESFVKDGAVVIDVGINVDEEGNLCGDVDTNAVLDKVSMITPVPAGVGSVTTSILAKHVVKACKLQNNK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Helicobacter hepaticus (strain ATCC 51449 / 3B1)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.647 kDa

Sequence

MTLLDGKSLSVTIERDLTEQIAALVSQGVTPGLAVILVGNNPASCAYVQMKAKACKRVGIYSVTHEMPSKITQDELLSVIEILNNDPNIDGILVQLPLPAHIQTSKVLEAINPKKDVDGFHPFNIGRLSVNVDTFVPATPLGVMKLLESYHIDVRGKDVVIIGMSNIVGKPLMSLMLNAGASVSCCHILTRDVKQYTKNADIVCVAVGKVGLLSADMIKEGAVVVDVGINRLESGTLVGDVDFENVAPKSSFITPVPGGVGPMTIVSLLQNTYKAAMYRLEQRMRV

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.65 kDa

Sequence

MTAQNIDGTLISQTVRSEVAARVKARVQAGLRAPGLAVVLVGEDPASQVYVGSKRRACEEVGFVSKSFDLPATASEEALLSLVEELNNDPQIDGILVQLPLPAGMDTTKVLESIHPEKDVDGFHPYNVGRLAQRIPKLRSCTPKGIITLLERYNIPLRGKHAVIVGASNIVGRPMTLELLLAGCTTTTCHRFTQDLEGHIRQADILVVAVGKPNFIPGAWIKEGAVVVDVGINRLDTGKLVGDVEYDVARTRASFITPVPGGVGPMTVASLIENTMMACEQFHTQG

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Vibrio campbellii (strain ATCC BAA-1116 / BB120)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.83 kDa

Sequence

MTAQNIDGTLISQTVRSEVAARVKARVEAGLRAPGLAVVLVGEDPASQVYVGSKRRACEEVGFVSKSFDLPATTSEEELLALIDELNNDAEIDGILVQLPLPAGIDATHVLERIHPEKDVDGFHPYNVGRLAQRIPKLRSCTPKGIITLLDRYNIELRGKHAVVVGASNIVGRPMTLELLLAGCTTTTCHRFTKDLEGHVRQADLVVVAVGKPNFIPGEWIKKGAVVVDVGINRLESGKLVGDVEYDKARENASFITPVPGGVGPMTVASLIENTMLACEQFHTKK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.65 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.806 kDa

Sequence

MTAQNIDGTLISQTVRSEVAARVKARVAAGLRAPGLAVVLVGEDPASQVYVGSKRRACEEVGFVSKSFDLPASTSEEELLALIDELNNDNEIDGILVQLPLPAGIDTTHVLERIHPEKDVDGFHPYNVGRLAQRIPKLRSCTPKGIITLLDRYNIELRGKHAVVVGASNIVGRPMTLELLLAGCTTTTCHRFTKDLESHVRQADVVVVAVGKPNFIPGEWIKKGAVVVDVGINRLDSGKLVGDVEYDKARESASFITPVPGGVGPMTVASLIENTMLACEQFHTEQ

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Wolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.092 kDa

Sequence

MQLLDGKALSLEIEAKVKEEVMILTSSRGVTPGLAVILVGSDPASQAYVNMKAKACKRAGIYSITHEMPESTTESQLLNAISILNNDPNIDGILVQLPLPKHINTAKVLEAIAPHKDVDGFHPQNVGRLTSNLGGFAPATPMGVMRLLQKYGIDPQGKNAVIVGASNIVGKPMASLLLNANATTTLCHIYTKDLASHTQNADILCVGVGKPNLITESMVKKGAVVIDIGINRLEDGSLVGDVDFASVAPKCSYITPVPGGVGPMTIASLLENTLKAAKTRQETPQS

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Bacillus anthracis (strain A0248)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.181 kDa

Sequence

MVAVIIKGNEVAEKKRAQLKEEVVKLKEQGIVPGLAVILVGEDPASRSYVKGKEKGCEQVGIYSELIEFPETITEERLLAEIDRLNGDDRINGILVQLPLPKHIEEKAIIERISPEKDVDGFHPISVGRMMTGQDTFLPCTPHGIVELVKETNLDISGKHVVVIGRSNIVGKPVGQLFLNENATVTYCHSKTQNMKELTKLADILIVAVGRPKMVTADYIKEGAVVIDVGVNRLETGKLCGDVDFDNVLDVASYITPVPKGVGPMTITMLLHNTVESAKRAGVVCK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Bacillus anthracis (strain CDC 684 / NRRL 3495)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.181 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Bacillus thuringiensis (strain Al Hakam)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.151 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Mycobacterium fortuitum

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.098 kDa

Sequence

MAPVGSIVLDGKATRDEIFVDLKQRVAKLTEAGRTPGLGTVLVGDDPGSQAYVRGKHADCAKVGINSIRRDLPADITQAQLDETIDELNANPDCTGYIVQLPLPKHLDENAALERIDPAKDADGLHPTNLGRLVLGKDAPLPCTPRGIVHLLRRFDVPIAGAHVVVIGRGVTVGRPMGLLLTRRSENATVTLCHTGTRDLPALTRQADIIIAAVGVPHMVTADMVKPGAAVVDVGVSRVDGKLTGDVAPDVWEVAGHVSPNPGGVGPLTRAFLLTNVVELEESKLA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Mycobacterium gilvum (strain PYR-GCK)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.265 kDa

Sequence

MMRVGAITLDGKATRDEIFVDLRERVARLAAAGRTPGLATVLVGDDPGSHAYVRGKHADCAKVGINSIRRDLPADISQAVLDETIDELNANPECTGYIVQLPLPKHLNENAALERIDPSKDADGLHPTNLGRLVLNEPAPLPCTPRGIVHLLRRFEVEIAGAHVAVLGRGVTVGRPLGLLLTRRSENATVTLCHTATRHLPEITREADIIVAAAGVPHMVTADMVRPGAAVVDVGVSRDDAGKLVGDVHPGVWDVAGHVSPNPGGVGPLTRAFLLTNVVERAEANL

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Shewanella piezotolerans (strain WP3 / JCM 13877)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.877 kDa

Sequence

MTAQNIDGKAIAQAIRTKLKDKVTARKEAGQRVPGLAVILVGADPASQVYVGSKRRACEELGFISRSYDLDSSTSEDALLSLIDECNEDQSIDGILVQLPLPEHIEESKVIERIRPDKDVDGFHPYNVGRLAQRIPVLRSCTPMGIMTLIQSTGVDTYGLDAVVVGASNIVGRPMSLELLLAGCTTTTCHRFTRNLEQKVRQADLVVVAVGKPGFIPGEWIKPGAIVIDVGINRLESGQLVGDVQFEKAAENASFITPVPGGVGPMTIASLLENTLYACEQYHDHD

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Shewanella woodyi (strain ATCC 51908 / MS32)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.82 kDa

Sequence

MTAQTIDGKAIAQSIRTQLKEKVTARKEAGKRVPGLAVILVGADPASQVYVGSKRRACEEVGFLSRSYDLESSTTEEQLLSLIDECNQDPAIDGILVQLPLPEHIEESKVIERIRPDKDVDGFHPYNVGRLAQRIPVLRSCTPMGIMTLIKSTGVDTYGLDALVVGASNIVGRPMSLELLLAGCTTTTCHRFTRNLEQKVRQADLVVVAVGKPGFIPGEWIKPGALVIDVGINRLEDGSLVGDVQYDVAAQNASFITPVPGGVGPMTIASLLENTLYAAEQYHDEA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Bacillus anthracis (strain A0248)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.181 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Bacillus anthracis (strain CDC 684 / NRRL 3495)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.181 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Bacillus thuringiensis (strain Al Hakam)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.151 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Mycobacterium fortuitum

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.098 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Mycobacterium gilvum (strain PYR-GCK)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.265 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Shewanella piezotolerans (strain WP3 / JCM 13877)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.877 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Shewanella woodyi (strain ATCC 51908 / MS32)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.82 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Desulfovibrio vulgaris subsp. vulgaris (strain DP4)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.38 kDa

Sequence

MQLLDGKATAATIREELRAEIAALTPRARRAPGLAVILVGEDPASQVYVRNKERACHDTGIVSEAFRLAPTTTQEELERLIADLNVRPDIDGILLQLPLPRGLDAQRCLEAIDPAKDVDGFHPQNMGRLALGLPGFRPCTPAGVMTLLERYDLSPSGRKAVVVGRSNIVGKPLALMLGAPGKYANATVTVCHSGTPDLAAECRTADFLFLAIGRPRFVTADMVREGAVVVDVGINRTETGLAGDCDFEGVSRVASAITPVPGGVGPMTIAQLLVNTVQSWKVRCGL

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Burkholderia cenocepacia (strain MC0-3)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.88 kDa

Sequence

MTALLIDGNALSKTLRAQAAERAAALTARGHQPGLAVILVGANPASEVYVRNKIKACEDNGFFSLKDAYPATLSEADLLARIHELNRDPKIHGILVQLPLPAHIDSHKVIEAIAPEKDVDGFHVANAGALMTGKPLFRPCTPYGVMKMFEAHGIALQGANAVVIGRSNIVGKPMAMMLLDAGATVTICHSKTRDLAAHTREADIVVAAVGKRNILTADMVKPGATVIDVGMNRDDAGKLCGDVDFAGVKEVAGYITPVPGGVGPMTITMLLINTIESAERAAAAAA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.902 kDa

Sequence

MTALLIDGNALSKTLRGQAAERAAALTARGHQPGLAVILVGENPASEVYVRNKIKACEDNGFFSLKDAYPATLSEADLLARIDELNRDPKIHGILVQLPLPAHIDSHKVIEAIAPEKDVDGFHVANAGALMTGKPLFRPCTPYGVMKMFEAHGIALQGANAVVIGRSNIVGKPMAMMLLDAGATVTICHSKTRDLAAHTREADIVVAAVGKRNILTADMVKPGATVIDVGMNRDDAGKLCGDVDFAGVKEVAGYITPVPGGVGPMTITMLLINTIESAERAAAAAA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.088 kDa

Sequence

MTALLIDGNALSKTLRAQAAERAAALTARGHQPGLAVILVGANPASEVYVRNKIKACEDNGFFSLKDAYPDTLSEADLLARIDELNRDPKIHGILVQLPLPKHIDSHKVIEAIAPEKDVDGFHIANAGALMTGKPLFRPCTPYGVMKMFEAHDIPLQGANAVVIGRSNIVGKPMAMMLLDAGATVTICHSKTRDLAAHTRQADIVVAAVGKRNILTADMVKPGATVIDVGMNRDDAGKLCGDVDFAGVKEVASHITPVPGGVGPMTITMLLINTIEAAERAADAAA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Thermodesulfovibrio yellowstonii (strain ATCC 51303 / DSM 11347 / YP87)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.538 kDa

Sequence

MSAEILDGKSLALKIKEELKKEVQDLKNQGINPCLAVVLVGENKSSQKYVSFKEKTCKELDIQSLVFKLPENTEETSLIKLIDELNENSQVNGILIQLPLPKHLNQNKVLERINPFKDVDGFTPFCLGRLLIDSPLFIPCTPKGIIRMLDEYKINLEGKQAVVIGRSIIVGKPLSLLLLKRNATVTMCHSKTINLQDITKKADILCVAIGREKFITSNMIKKGAVVIDIGINVTASGKVVGDVNFDDVKEKASYITPVPGGVGPMTIAMLMENAIYAAKLQKRVVK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Desulfovibrio salexigens (strain ATCC 14822 / DSM 2638 / NCIB 8403 / VKM B-1763)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.527 kDa

Sequence

MQILNGKETALTIREELKVEIDGLKEKHGRAPGLAVILVGEDPASQVYVRNKEIACEKAGIVSTAHRIDASVSQEELEALIQKLNADDTIDGILLQLPLPKGLDSQRCLELIDPGKDVDGFHPMNVGKLMLGLPGFRSCTPAGIITLLERYNLPTSGKKAVVVGRSNIVGKPLAMMLMQYGDFANATVTVCHSRTDNLAEEVKAADFVFAAIGIPKFIKKEMVKDGAVVVDVGINRTDEGLVGDCDYAALEDVASAMTPVPGGVGPMTIAQLLINTVQAYKEHVGA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Desulfovibrio alaskensis (strain G20)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.071 kDa

Sequence

MILLDGKATAAAVREELKKDVDALKDRAGRAPGLAVILVGDDPASQVYVRNKERACADAGIRSEAFRISAQTTQQELEERIAALNAREDIDGILLQLPLPAGLDSQRCLELIDPAKDVDGFHPVNMGKLTLGLPGFRPCTPAGVMTLLERYNLSPAGKKAVVLGRSNIVGKPLALMLGASGPFANATVTVCHSRTPDLAQQCREADFLFVAIGRANFVTADMVKPGAVVVDVGINRTENGLAGDVDFGPVSKVASAITPVPGGIGPMTIAQLLVNTVASWKKRCGV

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Desulfobacterium autotrophicum (strain ATCC 43914 / DSM 3382 / HRM2)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.699 kDa

Sequence

MAEVLKGKPVADALKAELTKNIEALKKDKGITPKLGIIRVGARPDDLFYEGGAKKTCAAVGMDCEIFEYPEDIDQASFEKAVTEVGAKKDVNGILMFSPLPKNLDERKIRTLIPVEKDVDCLTTGGAAKVFTDDATGFPPCTPTACMEMLHFYDIPIKGKKCVVVGRSLVVGKPLAMLLLREHGTVTICHSRTENLPGVCQDADILIAAVGRAKMVKADFVKKGQIVIDVGINADPDRPGKYCGDVDFETVEPVVTKITPVPAGVGSVTTSVLCKQTFMACQMQNA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / DSM 644 / NCIMB 8303)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.38 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Paraburkholderia phytofirmans (strain DSM 17436 / LMG 22146 / PsJN)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.95 kDa

Sequence

MTAKLIDGLALSKTLRADVAARAAALTARGHQPGLAVVLVGDNPASEVYVRNKVKACHDNGLGSSFDRYPADLPEAELLARIDELNRDPRIHGILVQLPLPPHIDSHKVIEAIAPEKDVDGFHVANAGALMTGRPLFRPCTPYGVMKMLAAYEIPLQGANAVVIGRSNIVGKPMALLLLEAGATVTICHSKTRDLAAHTRNADVVVAATGLRNILTAEMVKPGAAVIDVGMNRDDAGKLCGDVDFAGVKEVAGYITPVPGGVGPMTITMLLVNTIEAAEREAAANA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Spiroplasma citri

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.354 kDa

Sequence

MDKTKIIDGKMVSELIKAKITEQILKIKAKKQRVPALTIIQIGNNKASTTYIKNKKIACEKVGVTCKVLNYPDIITESALIKIINDLNNNSKIDAILVQLPLPSHINSEKVINTIITKKDVDGFTPKILGNLMLGHYNLLPSTPKGIIALLKHYQIQLAGQHVVIIGRSNIVGKPLANLLINASATVTVCHSQTKNLSDFTNQADILISAVGKAKFVTAEMIKENVIVIDVGINRDEDNNLCGDIDFHNVFSKVKMITPVPGGVGPMTIAALLENILYFYQLNQKI

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Staphylococcus aureus (strain Mu3 / ATCC 700698)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.888 kDa

Sequence

MVAKILDGKQIAKDYRQGLQDQVEALKEKGFTPKLSVILVGNDGASQSYVRSKKKAAEKIGMISEIVHLEETATEEEVLNELNRLNNDDSVSGILVQVPLPKQVSEQKILEAINPEKDVDGFHPINIGKLYIDEQTFVPCTPLGIMEILKHADIDLEAKNAVVIGRSHIVGQPVSKLLLQKNASVTILHSRSKDMASYLKDADVIVSAVGKPSLVTKDVVKEGAVIIDVGNTPDENGKLKGDVDYDAVKEIAGAITPVPGGVGPLTITMVLNNTLLAEKMRRGIDS

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Staphylococcus aureus (strain JH1)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.888 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Staphylococcus aureus (strain USA300)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.844 kDa

Sequence

MVAKILDGKQIAKDYRQGLQDQVEALKEKGFTPKLSVILVGNDGASQSYVRSKKKAAEKIGMISEIVHLEETATEEEVLNELNRLNNDDSVSGILVQVPLPKQVSEQKILEAINPEKDVDGFHPINIGKLYIDEQTFVPCTPLGIMEILKHADIDLEGKNAVVIGRSHIVGQPVSKLLLQKNASVTILHSRSKDMASYLKDADVIVSAVGKPGLVTKDVVKEGAVIIDVGNTPDENGKLKGDVDYDAVKEIAGAITPVPGGVGPLTITMVLNNTLLAEKMRRGIDS

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Staphylococcus aureus (strain NCTC 8325)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.844 kDa

Sequence

MVAKILDGKQIAKDYRQGLQDQVEALKEKGFTPKLSVILVGNDGASQSYVRSKKKAAEKIGMISEIVHLEETATEEEVLNELNRLNNDDSVSGILVQVPLPKQVSEQKILEAINPEKDVDGFHPINIGKLYIDEQTFVPCTPLGIMEILKHADIDLEGKNAVVIGRSHIVGQPVSKLLLQKNASVTILHSRSKDMASYLKDADVIVSAVGKPGLVTKDVVKEGAVIIDVGNTPDENGKLKGDVDYDAVKEIAGAITPVPGGVGPLTITMVLNNTLLAEKMRRGIDS

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Staphylococcus aureus (strain JH9)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.888 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Staphylococcus aureus (strain bovine RF122 / ET3-1)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.815 kDa

Sequence

MVAKILDGKQIAKDYRQGLQNQVEALKEKGFTPKLSVILVGNDGASQSYVRSKKKAAEKIGMISEIVHLEETATEEEVLNELNRLNNDDSVSGILVQVPLPKQVSEQKILEAINPDKDVDGFHPINIGKLYIDEQTFVPCTPLGIMEILKHADIDLEGKNAVVIGRSHIVGQPVSKLLLQKNASVTILHSRSKDMASYLKDADVIVSAVGKPGLVTKDVVKEGAVIIDVGNTPDENGKLKGDVDYDAVKEIAGAITPVPGGVGPLTITMVLNNTLLAEKMRRGVDS

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Staphylococcus aureus (strain COL)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.844 kDa

Sequence

MVAKILDGKQIAKDYRQGLQDQVEALKEKGFTPKLSVILVGNDGASQSYVRSKKKAAEKIGMISEIVHLEETATEEEVLNELNRLNNDDSVSGILVQVPLPKQVSEQKILEAINPEKDVDGFHPINIGKLYIDEQTFVPCTPLGIMEILKHADIDLEGKNAVVIGRSHIVGQPVSKLLLQKNASVTILHSRSKDMASYLKDADVIVSAVGKPGLVTKDVVKEGAVIIDVGNTPDENGKLKGDVDYDAVKEIAGAITPVPGGVGPLTITMVLNNTLLAEKMRRGIDS

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Staphylococcus aureus (strain Newman)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.844 kDa

Sequence

MVAKILDGKQIAKDYRQGLQDQVEALKEKGFTPKLSVILVGNDGASQSYVRSKKKAAEKIGMISEIVHLEETATEEEVLNELNRLNNDDSVSGILVQVPLPKQVSEQKILEAINPEKDVDGFHPINIGKLYIDEQTFVPCTPLGIMEILKHADIDLEGKNAVVIGRSHIVGQPVSKLLLQKNASVTILHSRSKDMASYLKDADVIVSAVGKPGLVTKDVVKEGAVIIDVGNTPDENGKLKGDVDYDAVKEIAGAITPVPGGVGPLTITMVLNNTLLAEKMRRGIDS

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Staphylococcus aureus (strain Mu50 / ATCC 700699)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.888 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Staphylococcus aureus (strain N315)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.888 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Staphylococcus aureus (strain MRSA252)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.829 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Staphylococcus aureus (strain MSSA476)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.844 kDa

Sequence

MVAKILDGKQIAKDYRQGLQDQVEALKEKGFTPKLSVILVGNDGASQSYVRSKKKAAEKIGMISEIVHLEETATEEEVLNELNRLNNDDSVSGILVQVPLPKQVSEQKILEAINPEKDVDGFHPINIGKLYIDEQTFVPCTPLGIMEILKHADIDLEGKNAVVIGRSHIVGQPVSKLLLQKNASVTILHSRSKDMASYLKDADVIVSAVGKPGLVTKDVVKEGAVIIDVGNTPDENGKLKGDVDYDAVKEIAGAITPVPGGVGPLTITMVLNNTLLAEKMRRGIDS

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Staphylococcus aureus (strain USA300 / TCH1516)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.844 kDa

Sequence

MVAKILDGKQIAKDYRQGLQDQVEALKEKGFTPKLSVILVGNDGASQSYVRSKKKAAEKIGMISEIVHLEETATEEEVLNELNRLNNDDSVSGILVQVPLPKQVSEQKILEAINPEKDVDGFHPINIGKLYIDEQTFVPCTPLGIMEILKHADIDLEGKNAVVIGRSHIVGQPVSKLLLQKNASVTILHSRSKDMASYLKDADVIVSAVGKPGLVTKDVVKEGAVIIDVGNTPDENGKLKGDVDYDAVKEIAGAITPVPGGVGPLTITMVLNNTLLAEKMRRGIDS

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Staphylococcus aureus (strain MW2)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.844 kDa

Sequence

MVAKILDGKQIAKDYRQGLQDQVEALKEKGFTPKLSVILVGNDGASQSYVRSKKKAAEKIGMISEIVHLEETATEEEVLNELNRLNNDDSVSGILVQVPLPKQVSEQKILEAINPEKDVDGFHPINIGKLYIDEQTFVPCTPLGIMEILKHADIDLEGKNAVVIGRSHIVGQPVSKLLLQKNASVTILHSRSKDMASYLKDADVIVSAVGKPGLVTKDVVKEGAVIIDVGNTPDENGKLKGDVDYDAVKEIAGAITPVPGGVGPLTITMVLNNTLLAEKMRRGIDS

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Alkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / MLHE-1)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.475 kDa

Sequence

MSAQILDGKAIAAELREQVRKQVEARVERGGRRPGLAVVLVGADPASTVYVGKKRQACEQLGMHSSAHELPAETTQDELLALVDELNGRDEIDGILVQLPLPDHIDEQTVIDRIHPDKDVDGFHPVNMGRLTLRLPGLRPCTPNGVMTMLAHAGIELEGKDAVIIGQSNIVGRPMAMELLNARCTITICHSRTRNLADRVRAADIVVAAVGRPGFVPGDWIKPGAVVIDVGINRLESGKLTGDVDFAAARELAGWITPVPGGVGPMTVATLMANTLAAAEARDSRA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Mesoplasma florum (strain ATCC 33453 / NBRC 100688 / NCTC 11704 / L1)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

32.104 kDa

Sequence

MIILDGKKVASRRKEELTAKISKYHNKGLRKPKLVVIMVGNDPASEVYVSHKIKVANEVGIYSELLRFDKDIKKEELYNKINELNNDQNIDGILLQLPLPIDFIEEDYLQAITPSKDVDGFHYINQGKMLQGYDTVYPCTPLGIINLLEEYNISVKNKDITLIGTSNIVGKPLGMMLLNNQATITMCNKNTKNIKNHTINADIIISATGKQFIITEDMIKKDAVIIDVGIIRDPVTNKLVGDVDFEKVKLKSSYITPVPGGVGPMTVITLMENTFVLYEKHINKSK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.001 kDa

Sequence

MPDTDNTKIIDGRAIAKKVEAEVKADVERLVREKGITPGLSAILVGEDPASKMYVRLKHKACGRVGIFAEDQHLPEDITQEELLEAISSLNARKDIHGILLQLPLPKHLNEQEAMNAIDPAKDADGFHPFNMGQLLIGVEELVPCTPKGIIRALEEYGVEIQGKHAVIVGHSNVVGKPMAAMLVNRNATVSICHVFTKDVTKFTRDADILVVATGVKHLIKEDMVKEGSVIFDVGITEENGKVYGDVDFENVIKKASRVTPVPGGVGPVTIATLMQHVLMSAQKTA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Bacillus anthracis

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.181 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Bacillus cereus (strain AH820)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.151 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Bacillus cereus (strain ATCC 10987 / NRS 248)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.124 kDa

Sequence

MVAVIIKGNEVAEKKRAQLTEEVVKLKEQGIVPGLAVILVGEDPASRSYVKGKEKGCEQVGIYSELIEFPETITEERLLAEIDRLNGDDRINGILVQLPLPKHIEEKAIIERISPEKDVDGFHPISVGRMMTGQDTFLPCTPHGIVELVKETNLDISGKHVVVIGRSNIVGKPVGQLFLNENATVTYCHSKTQNMKELTKLADILIVAVGRPKMVTADYLKEGAVVIDVGVNRLETGKLCGDVDFDNVLDVAGYITPVPKGVGPMTITMLLHNTVESAKRAGVVCK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Bacillus cereus (strain G9842)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.089 kDa

Sequence

MVAVIIKGNEVAEKKRAQLTEEVVKLKEQGIVPGLAVILVGEDPASRSYVKGKEKGCEQVGIYSELIELPETITEERLLAEIDRLNGDDRINGILVQLPLPKHIEEKAIIERISPEKDVDGFHPISVGRMMTGQDTFLPCTPHGIVELVKETNLDISGKHVVVIGRSNIVGKPVGQLFLNENATVTYCHSKTQNMKELSKLADILIVAVGRPKMITADYIKEGAVVIDVGVNRLETGKLCGDVDFDNVLNVAGYITPVPKGVGPMTITMLLHNTVESAKRAGVVCK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Bacillus cereus (strain 03BB102)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.151 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Bacillus cereus (strain B4264)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.063 kDa

Sequence

MVAVIIKGNEVAEKKRAQLTEEVVKLKEQGIVPGLAVILVGEDPASRSYVKGKEKGCEQVGIYSELIELPETITEERLLAEIDRLNGDDRINGILVQLPLPKHIEEKAIIERISPEKDVDGFHPISVGRMMTGQDTFLPCTPHGIVELVKETSLDISGKHVVVIGRSNIVGKPVGQLFLNENATVTYCHSKTQNMKELSKLADILIVAVGRPKMITADYIKEGAVVIDVGVNRLETGKLCGDVDFDNVLDVAGYITPVPKGVGPMTITMLLHNTVESAKRAGVVCK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Bacillus cereus (strain AH187)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.124 kDa

Sequence

MVAVIIKGNEVAEKKRAQLTEEVVKLKEQGIVPGLAVILVGEDPASRSYVKGKEKGCEQVGIYSELIEFPETITEERLLAEIDRLNGDDRINGILVQLPLPKHIEEKAIIERISPEKDVDGFHPISVGRMMTGQDTFLPCTPHGIVELVKETNLDISGKHVVVIGRSNIVGKPVGQLFLNENATVTYCHSKTQNMKELTKLADILIVAVGRPKMVTADYIKEGAVVIDVGVNRLETGKLCGDVDFDNVLDVAGYITPVPKGVGPMTITMLLHNTVESAKRAGVVCK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Bacillus cytotoxicus (strain DSM 22905 / CIP 110041 / 391-98 / NVH 391-98)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.321 kDa

Sequence

MVAVIIKGNEVAEKKRAQLKEEVVKLKEQGIVPGLAVILVGEDPASRSYIKGKQKGCEQVGIYSELIEFPDTITEERLLAEIDRLNEDDRINGILVQLPLPKHIEEKAIIERISPKKDVDGFHPINIGRMMTGQDTFLPCTPHGILELVKETNIDISGKHVVVIGRSNIVGKPVGQLFLNENATVTYCHSKTKNIKELSKLADILVVAVGRPKMVTADYIKEGAVVIDVGVNRLETGKLCGDVDFENVLDIAGYITPVPKGVGPMTITMLLHNTVESAKRAGFICK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Bacillus cereus (strain Q1)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.124 kDa

Sequence

MVAVIIKGNEVAEKKRAQLTEEVVKLKEQGIVPGLAVILVGEDPASRSYVKGKEKGCEQVGIYSELIEFPETITEERLLAEIDRLNGDDRINGILVQLPLPKHIEEKAIIERISPEKDVDGFHPISVGRMMTGQDTFLPCTPHGIVELVKETNLDISGKHVVVIGRSNIVGKPVGQLFLNENATVTYCHSKTQNMKELTKLADILIVAVGRPKMVTADYIKEGAVVIDVGVNRLETGKLCGDVDFDNVLDVAGYITPVPKGVGPMTITMLLHNTVESAKRAGVVCK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Bacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NRRL B-3711)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.09 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Bacillus cereus (strain ZK / E33L)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.181 kDa

Sequence

MVAVIIKGNEVAEKKRAQLKEEVVKLKEQGIVPGLAVILVGEDPASRSYVKGKEKGCEQVGIYSELIEFPETITEERLLTEIDRLNGDDRINGILVQLPLPKHIEEKAIIERISPEKDVDGFHPISVGRMMTGQDTFLPCTPHGIVELVKETNLDISGKHVVVIGRSNIVGKPVGQLFLNENATVTYCHSKTQNMKELTKLADILIVAVGRPKMVTADYIKEGAVVIDVGVNRLETGKLCGDVDFDNVLDVAGYITPVPKGVGPMTITMLLHNTVESAKRAGVVCK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Bacillus thuringiensis subsp. konkukian (strain 97-27)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.151 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Herpetosiphon aurantiacus (strain ATCC 23779 / DSM 785 / 114-95)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.569 kDa

Sequence

MTALLLDGRGLAKELKAQISQQGAEFKARTGYAPQLVVIQVAGNAASDWYVRSIRRSCEGVGFGFALQRLPETSDQATLEAAIQQASNDPAIHGIIIQMPLPSQLSADGAVAALNPQKDVDGLHPTNAGRLAQGLTALVPNTPAGGMALLDRYQINLAGKHAVVVGRSNVVGKPLAQLLLARHATVTICHSRTANLAEVIRQGDIVAAAVGKAGLVTGEMLKPGAVVLDFGINEVAEGQVVGDVDWESASKVASAITPVPGGTGPVTNMMLLQNTLQAAQSLAEQA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Idiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.798 kDa

Sequence

MPAQIIDGKTIAATVRQAVKQQVKERIDSGLRAPGLAVVLVGSDAASEVYVGNKRRACEDVGFRSFDYDLPITTTQKELEKLIEELNDDDAVDGILVQLPLPAGLDATPILERIRPDKDVDGFHPFNIGRLSQRIPALRPCTPKGIMTLLEHTHVDLHGLNAVVVGASNIVGRPMSLELLLAGATTTVCHRFTKDLSDHVKRADIVVVAVGKAEFIPGEWIKPGAIVIDVGMNRLPDGRLTGDVEFSVAAERAGWITPVPGGVGPMTVASLIENTLQACVDYHDVR

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Staphylococcus epidermidis (strain ATCC 35984 / RP62A)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.015 kDa

Sequence

MVAKILDGKQIAKEYRQRLKNQVNDLKEYGFTPKLSVILVGNDGASQSYVKSKKKAAEKIGMISEIIHLDESTSEEVVLSELNRLNNDDTVSGILVQVPLPKQVSEQKVLEAINPEKDVDGFHPINIGKLYIDEQTFVPCTPLGIMEILKHADINLEGKNAVVIGRSHIVGQPVSKLLLQANATVTILHSRTKNMNAHLKQADVIVSAVGQPGLVTKENVKKGAVIIDVGNTPDENGKLKGDVAYDEIKEIASAITPVPGGVGPLTITMVLNNTLLAEKLRRGLTK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Staphylococcus epidermidis (strain ATCC 12228)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.001 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.583 kDa

Sequence

MTKIIDGKAVAKKVNAQTATAVAELAAQGIQPGIAVIIVGDDAASQIYVRNKNRKATKLGMHSVVRQLPATTSQDELLAIIAAYNADDSIHGILVQSPLPAQINEPLITMAIDPKKDVDGFHPTNVGKLITNFPGNYPVANTPRGIMTMLADYGVDPAGKTAVVIGRSTIVGKPMAALLTNANATVTIAHSKTADLKAVARTADILVVATGIAHLITGADIKPGATVIDVGMDRDENGKLVGDVDFDSAQGIAGLITPVPGGVGPMTIATLMQTTVELAKWSDVSE

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Lactobacillus reuteri (strain DSM 20016)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.424 kDa

Sequence

MTTIIDGKALAKKINSQTKELVAQLKEKQNIIPGIAVVIAGDDVASLIYTRNKHNKAIKLGINSVLKKFPADVSQAELLAEIEKLNHDDTIDAILVQQPLPPQLDPEVITNAILPTKDVDGLNPLNLGKLFANQHGNYPVACTPRGIMRMLAEYNIDLQGKNAVIVGRSILVGKPLLALLNNANATVTMAGRSTGDLSALTKTADILIVATGVPNLIKATDVKPGAVVIDVGINRLSNGKLTGDVDFEAVKTKAQAITPVPGGVGPMTIATLMEQTVDLAWWRHHG

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Lactobacillus reuteri (strain JCM 1112)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.424 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Rickettsia prowazekii (strain Madrid E)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.56 kDa

Sequence

MVNNIIDGKALANEILADLKLEIQGFKEKTKTSPKLAIVLVGDNPASMIYVKNKIKNAHQVGIDTLLVNLSTNIYTDDLILKINELNLDKGISGIIVQLPLPSSIDENKILSAVLPSKDSDGFHPLNVGYLHSGINQGFIPCTALGCLAVIKKYAPNLNGKDAVIVGRSNIVGKPLSALLLQENCSVTICHSKTCNLSSITSKADIVVVAIGSPLKLTAEYFNPEAIVIDVGINRISHNKIAGDVDFENVKSKVKYITPVPGGIGPMTIAFLLKNTVKAFKNAIAL

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Bacillus weihenstephanensis (strain KBAB4)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.154 kDa

Sequence

MVAVIIKGNEVAEKKRAQLKEKVVKLKEQGIVPGLAVILVGEDPASRSYVKGKEKGCEQVGIYSELIELPETITEERLLVEIDRLNGDDRINGILVQLPLPKHIEEKAIIERISPEKDVDGFHPISVGRMMTGQDTFLPCTPHGILELVKETNLDISGKHVVVIGRSNIVGKPVGQLFLNENATVTYCHSKTRNIKELSKLADILIVAVGRPKMVTADYIKEGAVVIDVGVNRLETGKLCGDVDFDNVLDVAGYITPVPKGVGPMTITMLLHNTVESAKRAGVVCQ

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Blochmannia pennsylvanicus (strain BPEN)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.63 kDa

Sequence

MIAKIIDGKYVSEKIKQEIAKQVRKNMNSGKRAPGLAMILVGHNPISQIYVTNKKKACEQVGLISFLYTLPITATENEIFQLIETLNNDNRIDGILIQLPLPNKLNKINVLEHIAPDKDVDGFHPYNVGRLCQRSPTLRPCTSRGIITLLEWYNIDMFVLHAVVVGASNIVGRPMTMELLLAGCTVSVTHRFTQNLKIYIENADLLIVAVGQANFIPGSWIKQGAIVIDVGINRLNNGNIVGDVHFSSAYERAAYITPVPGGVGPMTVVTLIQNTLQAYDDHHLVR

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Paraburkholderia xenovorans (strain LB400)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.922 kDa

Sequence

MTAKLIDGLALSKTLRADVAARAAALTARGHQPGLAVVLVGDNPASEVYVRNKVKACHDNGLGSSFDRYPADLPEAELLARIDELNRDPRIHGILVQLPLPPHIDSHKVIEAIAPEKDVDGFHVANAGALMTGQPLFRPCTPYGVMKMLAAYEIPLQGANAVVIGRSNIVGKPMALLLLEAGATVTICHSKTRDLAAHTRNADVVVAATGLRNILTADMVKPGAAVIDVGMNRDEAGKLCGDVDFAGVKEVAGYITPVPGGVGPMTITMLLVNTIEAAEREAAANA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Symbiobacterium thermophilum (strain T / IAM 14863)

Length

286 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.374 kDa

Sequence

MTAGVIDGKQVAAQVQEEVAREVAALKAEGLTPGLAVVLVGDDPASKVYTANKERTAKELGMHSVLYHLPATTTQQELADLVMQLNRDPAIHGILVQSPLPEGLDMDAVIRLIDPRKDVDGFHPENVGRLWIGQDGLVPCTPAGVMRLLDAYGVDPKGKHAVVVGRSNIVGKPMAALLLQRHATVTICHSRTPDLAETCRRADILVAAVGRLQMITAEHVKPGAVVIDVGINPVPGFKKRIRGDVDFDSVQEVAGLITPVPGGVGPMTIAMLMANTVKAARMQTGR

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)

Length

285 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.353 kDa

Sequence

MPAIIIDGNKIAKKIELKILKKVKQRKKNGERIPGLAMILVGNHIPSQIYVNKKKISCKNVGFFSECWNLPSNINEKEILNIISKLNENKNIDGILIQLPLPPQINHMKILSSIVPDKDVDGFHPYNTGSLCQRTPKLRACTPKGIITMLKYNKIKTHGLHAVMVGASNIVGRPMSLELLLAGCTTTVTHRFTKNLKDHVQNADLLIVAVGKANFLKGSWIKTGSIVIDVGINRLKNGKVVGDVEFKTAYLRASYITPVPGGVGPMTVATLLQNTLEACENHDDI

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)

Length

285 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.609 kDa

Sequence

MSAIIIDGIKIAKKIELNLLKKIEEREKNKKRIPGLAVILIGKNPASEIYVKRKISVCKKVGFISKYWSFPINVDEKDILNLIEKLNNNINIDGILVQLPIPKQINYYKIFSSIRPDKDVDGFHPYNTGSLCQRNPTLRACTPKGIITMLNYTKIKTHGLNAVMVGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHIKNADLLVVAIGKPNFLHGDWIKEGAIVIDVGINKLKDGSIVGDVDFKSASLKAAYITPVPGGVGPITVITLLENTLEACEKYHEF

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Psychromonas ingrahamii (strain 37)

Length

285 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.577 kDa

Sequence

MTAQIIDGKAIATTITERVAKGVKLRIANGLRAPGLAVILVGGDPASQIYVGSKRRTCEAVGIHSKAFDLPETTTQDELLALIDKLNDDPDIDGILVQFPLPDGFDQTSVIERIKPDKDVDGFHPYNVGRLAQRIPLLRSCTPRGIISMLEYIGTEFHGKHAVVVGASNIVGRPMTLELLLAGCTTTTCHRFTTDLAHYVKQADILVVARGKANFIPGEWIKKGATVLDVGINRLEDGSLAGDVDFAGAKERAAWISPVPGGVGPMTVATLIENTLFACNEFHSQ

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Vibrio tasmaniensis (strain LGP32)

Length

285 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.548 kDa

Sequence

MTAQNIDGKLISQTVRSEVAARVKARTQAGLRAPGLAVVLVGEDPASQVYVGSKRKACEEVGFVSKSYDLPATATEDELLTLVDQLNEDPEIDGILVQLPLPAGIDSTQVLERITPEKDVDGFHPYNVGRLAQRMPKLRSCTPKGIITLLDRYNIDLRGKHAVVVGASNIVGRPMTLELLLAGCTTTTCHRFTKDLEGHVRQADVVVVAVGKPNFIPGAWIKKGAVVVDVGINRLESGKLVGDVEYDVAKESASFITPVPGGVGPMTVASLIENTMIACEQFHSK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Vibrio vulnificus (strain CMCP6)

Length

285 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.618 kDa

Sequence

MTAQNIDGTLISQTVRSEVAARVKARVAAGLRAPGLAVVLVGEDPASQVYVGSKRRACEEVGFVSKSFDLPASTSEEELLALIDELNNDAEIDGILVQLPLPAGIDSTHVLESIHPEKDVDGFHPYNVGRLAQRIPKLRSCTPKGIITLLERYNIALRGKHAVIVGASNIVGRPMTLELLLAGCTTTTCHRFTKDLEGHVRQADVLVVAVGKPNFIPGEWVKEGAIVVDVGINRLESGKLIGDVEYNKARERASFITPVPGGVGPMTVASLIENTMLACEQYHTK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Vibrio vulnificus (strain YJ016)

Length

285 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.618 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Corynebacterium jeikeium (strain K411)

Length

285 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.317 kDa

Sequence

MAATKLDGKLYRDEIFADLEQRVAALKEKGVTPGLATVLVGDDPASHSYVRMKHKDCEQIGVNSIRKDLPADVSQEELNAVIDELNADDACTGYIVQLPLPKHLDENAVLERIDPDKDADGLHPVNLGKLVLNEPAPLPCTPNGAIHLLRRFDVELNGAKVVVIGRGVTVGRPIGLMLTRRSENSTVTLCHTGTKDLAAETKAADVIVAAAGVPHMITADMVKPGAAILDVGVSRGEDGKLKGDVHPDVWDVAGAVSPNPGGVGPLTRAFLVRNVVERAEKLLRA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34)

Length

285 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.005 kDa

Sequence

MSAHLIDGNALAKQIRAEAAQRAARLTAAGHQPGLAVVLVGEDPASQVYVRNKVKACEDNGFYSSLNRYPADLSEADLLARIDELNNDPKIHGILVQLPLPKHIDSHKVLEAIAPEKDVDGFHVANAGALMTGAPLFRPCTPYGCMKMLESIQYPLRGARAVVVGASNIVGKPMAMMLLQAGATVTICNSKTRDLAAHTRDADVIVAAVGRRNIITADIVKPGAVVIDVGMNRDDAGKLCGDVDFAGVREVAGHITPVPGGVGPMTITMLLINTLEAAEREAGIA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Corynebacterium jeikeium (strain K411)

Length

285 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.317 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34)

Length

285 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.005 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Mycobacterium sp. (strain MCS)

Length

285 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.17 kDa

Sequence

MGAITLDGKATRDEIFVDLKERVAALTEQGRTPGLGTVLVGDDPGSQAYVRGKHSDCAKVGINSIRRDLPADISQAELDATIDELNANPECTGYIVQLPLPKHLDENAALERIDPGKDADGLHPTNLGRLVLNEPAPLPCTPRGIVHLLRRYEVEIAGAHVVVIGRGVTVGRPLGLLLTRRSENATVTLCHTATRHLPQFTREADIIVAAAGVPHMVTAEMVRPGAAVIDVGVSRDDNGKLVGDVAPDVWEVAGHVSPNPGGVGPLTRAFLLTNVVERAEALARG

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)

Length

285 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.742 kDa

Sequence

MTQIIDGKALAAKLQGQLAEKTAKLKEETGLVPGLVVILVGDNPASQVYVRNKERSALAAGFRSEVVRVPETITQEELLDLIAKYNQDPAWHGILVQLPLPKHIDEEAVLLAIDPEKDVDGFHPLNMGRLWSGHPVMIPSTPAGIMEMFHEYGIDLEGKNAVVIGRSNIVGKPMAQLLLAKNATVTLTHSRTHNLSKVAAKADILVVAIGRAKFVTADFVKPGAVVIDVGMNRDENGKLCGDVDYEAVAPLASHITPVPGGVGPMTITMLMEQTYQAALRTLDRK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Streptococcus pneumoniae (strain ATCC BAA-255 / R6)

Length

285 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.68 kDa

Sequence

MTQIIDGKALAAKLQGQLAEKTAKLKEETALVPGLVVILVGDNPASQVYVRNKERSALAAGSRSEVVRVPETITQEELLDLIAKYNQDPAWHGILVQLPLPKHIDEEAVLLAIDPEKDVDGFHPLNMGRLWSGHPVMIPSTPAGIMEMFHEYGIDLEGKNAVVIGRSNIVGKPMAQLLLAKNATVTLTHSRTHNLAKVAAKADILVVAIGRAKFVTADFVKPGAVVIDVGMNRDENGKLCGDVDYEAVAPLASHITPVPGGVGPMTITMLMEQTYQAALRTLDRK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Sulfurimonas denitrificans (strain ATCC 33889 / DSM 1251)

Length

285 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.353 kDa

Sequence

MQLLDGKALSAKIETTVAKEVKELKNSTNLVPGLAVILVGQDPASAAYVNMKKKACDRVGFYSVTHEMPSDISQSAIENTITMMNNNPNIDGILIQLPLPTQIDTTKILELVEPSKDVDGFHPYNVGRLTTGLDGFVPCTPLGVMELLKEYKIDVKGKNCVVVGASNIVGKPMAALLLNANATVEICHIFTDDLKKHTLAADMIFVGAGVINLIKEDMVKGGAIIVDIGINRAESGKLVGDVDFENVAKKCSFITPVPGGVGPMTIAMLLSNTLKAAKAHAKENE

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Burkholderia ambifaria (strain MC40-6)

Length

285 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.893 kDa

Sequence

MTALLIDGNALSKTLRTQAAQRAAALTARGHQPGLAVVLVGANPASEVYVRNKIKACEDNGFFSQKDAYPDTLSEADLLARIDELNHDPKIHGILVQLPLPAHIDSHKVLEAIAPEKDVDGFHVANAGALMTGKPLFRPCTPYGVMKMFEAHDIPLQGANAVVIGRSNIVGKPMAMLLLEAGATVTICHSKTRDLAAHTRQADIVVAAVGKRNILTADMVKPGATVIDVGMNRDDAGKLCGDVDFAGVKEIAGHITPVPGGVGPMTITMLLINTIEAAERAAAAA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Burkholderia cenocepacia (strain AU 1054)

Length

285 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.759 kDa

Sequence

MTALLIDGNALSKTLRAQAAERAAALTARGHQPGLAVILVGANPASEVYVRNKIKACEDNGFFSLKDAYPATLSEADLLARIDELNRDPKIHGILVQLPLPAHIDSHKVIEAIAPEKDVDGFHVANAGALMTGKPLFRPCTPYGVMKMFEAHGIALQGANAVVIGRSNIVGKPMAMMLLDAGATVTICHSKTRDLAAHTREADIVVAAVGKRNILTADMVKPGATVIDVGMNRDDAGKLCGDVDFAGAKEVAGYITPVPGGVGPMTITMLLINTIESAERAAAAA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Burkholderia cenocepacia (strain HI2424)

Length

285 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.787 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Burkholderia ambifaria (strain ATCC BAA-244 / AMMD)

Length

285 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.925 kDa

Sequence

MTALLIDGNALSKTLRTQAAQRAAALTARGHQPGLAVVLVGANPASEVYVRNKIKACEDNGFFSHKDAYPDTLSEADLLARIDELNRDPKIHGILVQLPLPAHIDSHKVLEAIAPEKDVDGFHVANAGALMTGKPLFRPCTPYGVMKMFEAHDIPLQGANAVVIGRSNIVGKPMAMMLLEAGATVTICHSKTRDLAAHTRQADIVVAAVGKRNILTADMVKPGATVIDVGMNRDDAGKLCGDVDFAGVKEVAGHITPVPGGVGPMTITMLLINTIEAAERAAAAA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Burkholderia multivorans (strain ATCC 17616 / 249)

Length

285 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.855 kDa

Sequence

MTALLIDGNALSKTLRAQAAERAAALTARGHRPGLAVILVGDNPASEVYVRNKIKACEDNGFFSQKDTYPATLSEADLLARIDELNRDPKIHGILVQLPLPAHIDSHKVIEAIAPEKDVDGFHVANAGALMTGKPLFRPCTPYGVMKMFAAHGIALQGANAVVIGRSNIVGKPMAMLLLEAGATVTICHSKTRDLAAHTRQADIIVAAVGKRNILTADMVKPGATVIDVGMNRDDAGKLCGDVDFAGVKEVAGYITPVPGGVGPMTITMLLINTLESAERAAAAA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Burkholderia mallei (strain NCTC 10247)

Length

285 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.873 kDa

Sequence

MTATLIDGNALSKTLRAQAAERAAALAARGHRPGLAVILVGDNPASEVYVRNKIKACEDNGFFSLKDRYPATLSEPELLARIDELNRDPKIHGILVQLPLPAHIDSHKVIEAIAPEKDVDGFHVANAGALLTGKPLFRPCTPYGVMKMFEAYKIPLQGANAVVIGRSNIVGKPMALLLLEAGATVTICHSKTCELAAHTRAADIVVAAVGKRNVLTADMVKPGATVIDVGMNRNDEGKLCGDVDFAGVSQVAGHITPVPGGVGPMTITMLLVNTIEAAERAAAAA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Burkholderia mallei (strain NCTC 10229)

Length

285 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.873 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Burkholderia mallei (strain ATCC 23344)

Length

285 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.873 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Burkholderia mallei (strain SAVP1)

Length

285 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.873 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Burkholderia pseudomallei (strain 1106a)

Length

285 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.898 kDa

Sequence

MTATLIDGNALSKTLRAQAAERAAALAARGHQPGLAVILVGDNPASEVYVRNKIKACEDNGFFSLKDRYPATLSEPELLARIDELNRDPKIHGILVQLPLPAHIDSHKVIEAIAPEKDVDGFHVANAGALLTGKPLFRPCTPYGVMKMFEAYKIPLQGANAVVIGRSNIVGKPMALLLLEAGATVTICHSKTRELAAHTRAADIVVAAVGKRNVLTADMVKPGATVIDVGMNRNDEGKLCGDVDFAGVSQVAGHITPVPGGVGPMTITMLLVNTIEAAERAAAAA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Burkholderia pseudomallei (strain 1710b)

Length

285 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.926 kDa

Sequence

MTATLIDGNALSKTLRAQAAERAAALAARGHRPGLAVILVGDNPASEVYVRNKIKACEDNGFFSLKDRYPATLSEPELLARIDELNRDPKIHGILVQLPLPAHIDSHKVIEAIAPEKDVDGFHVANAGALLTGKPLFRPCTPYGVMKMFEAYKIPLQGANAVVIGRSNIVGKPMALLLLEAGATVTICHSKTRELAAHTRAADIVVAAVGKRNVLTADMVKPGATVIDVGMNRNDEGKLCGDVDFAGVSQVAGHITPVPGGVGPMTITMLLVNTIEAAERAAAAA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Burkholderia pseudomallei (strain 668)

Length

285 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.926 kDa

Sequence

MTATLIDGNALSKTLRAQAAERAAALAARGHRPGLAVILVGDNPASEVYVRNKIKACEDNGFFSLKDRYPATLSEPELLARIDELNRDPKIHGILVQLPLPAHIDSHKVIEAIAPEKDVDGFHVANAGALLTGKPLFRPCTPYGVMKMFEAYKIPLQGANAVVIGRSNIVGKPMALLLLEAGATVTICHSKTRELAAHTRAADIVVAAVGKRNVLTADMVKPGATVIDVGMNRNDEGKLCGDVDFAGVSQVAGHITPVPGGVGPMTITMLLVNTIEAAERAAAAA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Burkholderia pseudomallei (strain K96243)

Length

285 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.926 kDa

Sequence

MTATLIDGNALSKTLRAQAAERAAALAARGHRPGLAVILVGDNPASEVYVRNKIKACEDNGFFSLKDRYPATLSEPELLARIDELNRDPKIHGILVQLPLPAHIDSHKVIEAIAPEKDVDGFHVANAGALLTGKPLFRPCTPYGVMKMFEAYKIPLQGANAVVIGRSNIVGKPMALLLLEAGATVTICHSKTRELAAHTRAADIVVAAVGKRNVLTADMVKPGATVIDVGMNRNDEGKLCGDVDFAGVSQVAGHITPVPGGVGPMTITMLLVNTIEAAERAAAAA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Burkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CIP 106301 / E264)

Length

285 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.911 kDa

Sequence

MTATLIDGNALSKTLRAQAAKRAAALAARGHRPGLAVILVGDNPASEVYVRNKIKACEDNGFFSLKDRYPATLSEPELLARIGELNRDPKIHGILVQLPLPAHIDSHKVIEAIAPEKDVDGFHVANAGALLTGKPLFRPCTPYGVMKMFEAYKIPLQGANAVVIGRSNIVGKPMALLLLEAGATVTICHSKTRDLAAHTREADIVVAAVGKRNVLTADMVKPGATVIDVGMNRNDEGKLCGDVDFAGVSQVAGHITPVPGGVGPMTITMLLVNTIEAAERAAAAA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Pseudoalteromonas atlantica (strain T6c / ATCC BAA-1087)

Length

285 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.779 kDa

Sequence

MPAQKIDGKLIAQQVRQHVKSHVESIVSSGKRPPGLAVVLVGSDAASHVYVTNKRRACEEVGFVSKSYDLPSTTSQQKLLELIDTLNADEEIDGILVQLPLPAGLDKEQVLERILPHKDVDGFHPYNIGRLAQRIPALRPCTPKGIMTLIESTKRPIKGLDAVIVGASNIVGRPMFMELLLAGCTVTSCHKFTKDLQSHVERADLIVVAVGISAFIPGEWIKPGAIVIDVGINRQTDGTLIGDVDYATAEKRAGWITPVPGGVGPMTVASLIENTLEAYVKYHSN

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Thioalkalivibrio sulfidiphilus (strain HL-EbGR7)

Length

285 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.681 kDa

Sequence

MTARLIDGRQVAQQVHEEVRQAVERHTAQGRRAPGLAVVLVGENPASQVYVRNKRRTCEALGIESRSHDLPADTPQSVLLDLIDALNADPAVDGILVQLPLPAHFDTETVIERIDPAKDVDGFHPYNVGRLAVRLPTLRPCTPYGVMRLLDSTGEVYKGRNAVVVGASNIVGRPMALELMLAGATVTVCHRFTTDTAEHVARADIVVVAVGRPDLVPGEWIKPGATVIDVGMNRLEDGRLVGDVSFAAAAERAAWITPVPGGVGPMTVAMLMKNTIQSYESRLGR

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Verminephrobacter eiseniae (strain EF01-2)

Length

285 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.899 kDa

Sequence

MTAHTIDGLALSRQLRSALAQRAAALTARGHQPGLAVILVGEDPASAIYVRNKIRACQDNGLRSVLEKYTANLSQAALLERIAALNADPGVHGILVQMPLPKHIDPHRVTEAIASTKDVDGYSVLSAGALLAGLDGFRPCTPYGCMKLIESTGQAIAGRHAVIVGRSQTVGKPMALLLLQANATVTLCHSATPDLGYHTRQADIVVAAVGRARMLTAEMVKPGAIVIDVGINRQADGKLCGDVDFDRVKQVAGWITPVPGGVGPMTITMLLVNTMQATERSAANP

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Desulfovibrio desulfuricans (strain ATCC 27774 / DSM 6949)

Length

285 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.298 kDa

Sequence

MLIIDGKKTAQDIRAELATEVTAATAEGRRAPGLAVILVGEDPASQVYVRNKEKACTEVGITSFAYRLPAETGQQELLDLIAECNARPDVDGILLQLPLPRGLDAQACLLAIDPAKDVDGFHPENVGRLSLGLPGFVSCTPAGVMELLRRYNLPTRGKKAVVVGRSDIVGKPLALLLTRSGEFGDATVTICHSRTPDLAEECRKADFLFLAVGRPRLITGDMVRQGAVVIDVGINRSDDGLCGDADYESVSKKAAAITPVPGGVGPMTIAMLLVNTVQSWRQRTA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Oceanobacillus iheyensis (strain DSM 14371 / CIP 107618 / JCM 11309 / KCTC 3954 / HTE831)

Length

285 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.12 kDa

Sequence

MATLLNGKELSEELKQKMKIEVDELKEKGLTPHLTVILVGDNPASKSYVKGKEKACAVTGISSNLIELPENISQDELLQIIDEQNNDDSVHGILVQLPLPDQMDEQKIIHAISPAKDVDGFHPINVGKMMTGEDTFIPCTPYGILTMLRSKDISLEGKHAVIIGRSNIVGKPIGLLLLQENATVTYTHSRTKNLQEITKQADILIVAIGRAHAINADYIKEDAVVIDVGINRKDDGKLTGDVDFESAEQKASYITPVPRGVGPMTITMLLKNTIKAAKGLNDVER

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Oenococcus oeni (strain ATCC BAA-331 / PSU-1)

Length

285 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.225 kDa

Sequence

MVQILDGRSVSKKILQEVKDKVAKAGFPVKLATIYNEENEGSKMYVGMKIRRATFAGLISVEYKVDNSWKTDDILRLLSKLNMDSSICGILVQSPLGDGIDESKIFNAIDPLKDADGLSAFNQGLLFENAKENYIVPATPAGVISLLEAYHYQFAAKNALVVGRSVLFGRPMSVLLTNRDMTVTLAHSKTPVDQLRQFAKRADLIVVAIGKANWFQFTDLKKDVVVIDVGANKLNGHATGDVDFEKVYPHVSQISPVPGGVGPMTIATLIKHTFDLAVFQQGEQK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Actinobacillus pleuropneumoniae serotype 5b (strain L20)

Length

285 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.265 kDa

Sequence

MTAHIISGTAVAKQVKANIAEQIQAYTAQDKRKPGLAVILVGMDPASQVYVNSKRKSCAEIGIESKSYDLPAETGEAELLAIIEQLNHDDSVDGILVQLPLPKQIDATKVTEAIVPHKDVDGFHPYNVGRLCQKIPTLRSCTPYGVMKLLESTGVNLAGLHAVVVGASNIVGRPMAMELLLAGCTVTITHSRTKDLAYHVSQADIVVAGVGKPNFVKGEWIKPGAIVIDVGINRVEGKLIGDVEYSAAEAKASFITPVPGGVGPMTVAMLMQNTLQAYQVHLQAV

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Actinobacillus pleuropneumoniae serotype 7 (strain AP76)

Length

285 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.251 kDa

Sequence

MTAHIISGTAVAKQVKANIAEQIQAYTAQDKRKPGLAVILVGMDPASQVYVNSKRKSCAEIGIESKSYDLPAETGEAELLAIIEQLNHDDSVDGILVQLPLPKQIDATKVTEAIVPHKDVDGFHPYNVGRLCQKIPTLRSCTPYGVMKLLESTGVNLAGLHAVVVGASNIVGRPMAMELLLAGCTVTVTHSRTKDLAYHVSQADIVVAGVGKPNFVKGEWIKPGAIVIDVGINRVEGKLIGDVEYSAAEAKASFITPVPGGVGPMTVAMLMQNTLQAYQVHLQAV

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Actinobacillus pleuropneumoniae serotype 3 (strain JL03)

Length

285 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.251 kDa

Sequence

MTAHIISGTAVAKQVKANIAEQIQAYTAQDKRKPGLAVILVGMDPASQVYVNSKRKSCAEIGIESKSYDLPAETGEAELLAIIEQLNHDDSVDGILVQLPLPKQIDATKVTEAIVPHKDVDGFHPYNVGRLCQKIPTLRSCTPYGVMKLLESTGVNLAGLHAVVVGASNIVGRPMAMELLLAGCTVTVTHSRTKDLAYHVSQADIVVAGVGKPNFVKGEWIKPGAIVIDVGINRVEGKLIGDVEYSAAEAKASFITPVPGGVGPMTVAMLMQNTLQAYQVHLQAV

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Actinobacillus succinogenes (strain ATCC 55618 / DSM 22257 / 130Z)

Length

285 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.8 kDa

Sequence

MAVQVISGTELAKKTKSEVAGQIRRYISLGRRVPGLAVILVGSDPASQVYVGSKRKSCAEIGIDSKSYDLPETTTEAELLSIIDDLNRNPNVDGILVQLPLPKHIDSTKVIERIAPNKDVDGFHPYNVGRLCQRIPTLRACTPYGIMKLLETTGQDLHGLHAVIVGASNIVGRPMAMELLLAGCTVTVTHRFTRDLEEHVRRADILVVAVGKAEFINGDWIKPGATVIDVGINRGEDGKLRGDVQYAKAAEKAAFITPVPGGVGPMTVAMLMVNTLTAYERHFNA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Aliivibrio fischeri (strain ATCC 700601 / ES114)

Length

285 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.79 kDa

Sequence

MTAQIIDGKLISQTVRSEVGARVKARVEAGLRAPGLAVVLVGQDPASQVYVGSKRRACEEVGFVSKSYDLPTTTSESELLNLIDELNQDPEIDGILVQLPLPAGMDSTKILEHIDPEKDVDGFHPYNVGRLSQRIPKLRSCTPKGIITLLDRYNIQVRGMHAVVVGASNIVGRPMTLELLLAGCTTTTCHRFTKDLESHIRQADLVVVAVGKPNFIPGEWIKEGAVVVDVGINRLDSGKLIGDVEYDVAKTKASYITPVPGGVGPMTVATLIENTLLACEQYHSK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Aliivibrio fischeri (strain MJ11)

Length

285 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.79 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Aliivibrio salmonicida (strain LFI1238)

Length

285 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.779 kDa

Sequence

MTAQIIDGKLISQTVRSEVGARVKARIEAGLRAPGLAVVLVGQDPASQVYVGSKRRACEEVGFVSKSYDLPTTTTEAELLTLIDTLNQDPEIDGILVQLPLPAGMDSTKILEHIDPEKDVDGFHPYNVGRLSQRIPKLRSCTPKGIITLLDRYNIQVRGMHAVVVGASNIVGRPMTLELLLAGCTTTTCHRFTKDLEHHIRQADLVVVAVGKPNFIPGEWIKEGAVVVDVGINRLDTGKLIGDVEFDVAKTKASYITPVPGGVGPMTVASLIENTLLACEQFHSK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Alkaliphilus oremlandii (strain OhILAs)

Length

285 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.877 kDa

Sequence

MSNVLKGKPVADKISEGLIQEVEVLKEKGITPKLAILRVGARGDDLAYEKGALSRCAKIGIDTEVKEFPEDITQEDFIEALRKTNGDPSIHGILIFRPLPKQLNEDVIKYEIAAEKDIDCLSPINAAKLLEGDDTGFPPCTPMAVIEILKHYEVQMEGKKAVVLGRSMVVGKPAALLLLKENATVTICHSRTKELSSVTKEGDILVAAIGKDRFVKEDFIKEGAVVIDVGINVDAEGNMYGDVDFEGCKEKAGMITPVPAGVGSVTTSILAKHVLKACRLQHNIY

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372)

Length

285 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.787 kDa

Sequence

MEAKVLNGKELSTKIKEELKIEVEDLKKNNINPGLAVIIVGNDPASRVYVNSKKKACAEIGIESFEYALEENTTQEELIELIHKLNKDDKVSGILVQLPLPKHIDEEKVIYAIDPSKDVDAFHPVNVGKLMIGNPDFLPCTPAGVMELIKESGIDITGKECVVVGRSNIVGKPMAMLLLAQNGTVTVCHSRTQNIDEVCKRADILVVAVGKPEFIKGSSIKPGAVVIDVGINRLENKKLVGDVEYESASRVASAITPVPGGVGPMTIAMLMKNTVKAAKLQAKMK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Microcystis aeruginosa (strain NIES-843)

Length

285 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.411 kDa

Sequence

MSVTTCQILDGKALAQKIQLGLGERIQTLKSPMGRPPGLAVLMVGDNPASAVYVRNKEKACTKIGMASFGRHFSTDTSELEILAEIVRLNQDERVDGILIQLPLPKHLDAVSLLYQIDPKKDADGLHPLNLGGLVRGEDCIRSCTPAGVMALLKEYNIPIAGKHAVVVGRSILVGKPLALMLLEENATVTIAHSRTENLAEITRSADILVPAVGKANLITKDMVKPGAVVVDVGINRVADRLVGDVDYAGVLEVASYLTPVPGGVGPMTVAMLLKNTLLSYERKL

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Lactobacillus fermentum (strain NBRC 3956 / LMG 18251)

Length

285 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.248 kDa

Sequence

MVELIDGKQLAKQLNEETATRVAALKKRGITPGIAVILVGDDPASAIYTRNKHRKAEKLGMKSVLKTFPADASQEEVMACVQELNNDPSIHAILVQSPLPKHFDEKALDNAIIPEKDVDGFHPYNVGRLYNDDPDKRYPVSCTPRGVLKMLDHYNVDLDGKDVVVMGRSILVGKPMQSLLQNRNATVTMLSAHTKDEEFYMRHADILIVAIGHPQFVKAQDVKEGAVVIDVGINRLEDGSLCGDVDFENVKEKASLITPVPGGVGPMTIASLMAQTVDLAEWSEE

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Staphylococcus carnosus (strain TM300)

Length

285 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.839 kDa

Sequence

MVAKILDGKQIAKDYRQGLQDQVEALKEKGYTPKLSVILVGNNGASLSYVKSKKKAAEKIGMISEIVHLEETATEEEVLNELERLNNDDSVSGILVQVPLPSQVSEQKVLEAINPEKDVDGFHPQNIGKLYIDEQTFVPCTPLGIMELLKNADIDLDGKDAVVIGRSHIVGQPVSKLLIQQNATVTILHSHSKDMSKYLKEADVIVSAVGKPGLVTKEDVKEGAVVIDVGNTPDENGKLKGDVEYEDVKEVAGAITPVPGGVGPMTITMVLNNTLLAEKMRRGLE

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Staphylococcus haemolyticus (strain JCSC1435)

Length

285 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.834 kDa

Sequence

MVAKILDGKQISKDYRQGLQEQVEALKEKGYTPKLSVILVGNDGASQSYVNSKKKAAEKIGMISEIVHLDEDTSEEDVLKELDRLNNDDSVSGILVQVPLPKQVSEQKILEAINPEKDVDGFHPSNIGKLYIDEQTFVPCTPLGIMEILKHADIDLEGKNAVVIGRSHIVGQPVSKLLLQANATVTILHSRTKDMHSHLKDADVIVSAVGQPGLVTKDDVKEGAVIVDVGNTPDENGKLKGDVEFEEVKEVAGAITPVPGGVGPLTITMVLNNTLLAEKMRRGIE

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)

Length

285 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.852 kDa

Sequence

MVAKILDGKQIAKDYRQGLKDQVEALQAEGYTPKLSVILVGNDGASQSYVNSKKKAAEKIGMISEIVHLDESTSEADVLNELKRLNEDDSVSGILVQVPLPDQVSEQKVLESINPAKDVDGFHPENIGKLYIDQQTFVPCTPLGIMELLNHADIDLEGKDAVVIGRSHIVGQPVSKLLLQKNASVTILHSRTKDMKRYLKNADIIVSAVGRPGLVTKEDVKEGAVVIDVGNTPDENGKLKGDIEYDEVKEVAGAITPVPGGVGPMTITMVLNNTLIAEKMRRGIE

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)

Length

285 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.68 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)

Length

285 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.478 kDa

Sequence

MSARILDGKALAQELRAEAAAQIAELRTQIDRPPTIAVVQVGDDPAATRYVRSIDRLCQSLGAACRAIALPAETAQADLEATVATLSADDRIDGILLQLPLPAGLTLDGVLSRLAPEKDLDGIHPINAGLLAQGRPTLTPNTPAGGIELMRRYGIDIRGRRAAVVGRSAIVGRPMALLLLQADATVTICHSRTPDLGAVLRECDIIAAAAGRPGLITADMVKPGATVIDFGTNVLADGSMVGDVDFAAVAEVAGAITPVPGGTGPVTNIMLMRNLITATRTRLGI

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Chloroflexus aggregans (strain MD-66 / DSM 9485)

Length

285 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.934 kDa

Sequence

MSARILDGRVLAQALRHELAAQIAELRERIDRAPVIAVVQVGEDPAATRYVRSIDRLSQSLGAACRTIILPDVVTQAELEATVSRLSADDRVDGILLQLPLPAGLSLDGVLSRLIPEKDLDGIHPINAGLLAQGRPALIPNTPAGGMELLRRYEIEVRGKRAAVVGRSAIVGRPMALLLLQADATVTICHSRTSDLGAVLRECDIIVAAAGRPQLITAEMIKPGATIIDFGTNVLADGSMVGDVDFAAAVEVAGAITPVPGGTGPVTNVMLIQNLIKATRSRLGI

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Lactococcus lactis subsp. cremoris (strain MG1363)

Length

285 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.165 kDa

Sequence

MNLIDGKALAAKMQAELKVKVDKLKEAGSVPGLAVILVGEDPASQIYVRNKARQATAIGLNSSVVRLPETVSEKELLELIEQYNQSEQWHGILVQLPLPKHISEEKVLLAIDPEKDVDGFHPMNMGRLWAGNPLMIPSTPAGIMEMFREYNVELSGKRAVVIGRSNIVGKPMAQLLMMADATVTIAHSRTKNLRELTKEADILVVAIGRDRMIKADDVKDGAVVIDVGMNRDEDGKLHGDVDFDEVKEVASLITPVPGGVGPMTITMLMEQTVRAATRKMNENSN

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Lactococcus lactis subsp. cremoris (strain SK11)

Length

285 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.165 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Lactobacillus salivarius (strain UCC118)

Length

285 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.019 kDa

Sequence

MVATILDGRMLSKKIRTNVSEKVSLLKQEGITPKLVVILVGEDPASQVYVRNKRKTAHALGIEAVDIRLPENVEEDELIRLIDELNSDGTVHGILVQLPLPKHINENKVTHRIIPEKDVDGFHPLNIGKLFMNIPGPLPCTPRGIMEFFKEYDIPVSGKRVVIVGRSNIVGRPMAALLVNSDATVTIAHSKTKNLAEVTKQADILIVAIGKGEFIDENYVKKGAVVIDVGMNRNNDGKLVGDVNMESVSKVASYITPVPGGVGPMTIAMLMKQTVELAERSVAGE

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Rickettsia typhi (strain ATCC VR-144 / Wilmington)

Length

285 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.547 kDa

Sequence

MNNIIDGKALANEILADLKLEIQGFKEKTQTSPKLAIVLVGDNPASMIYIKNKIKNAQQVGIDTLLVNLSTNIYTDDLISKINELNLDKEISGIIVQLPLPSSIDENKILSAVLPSKDSDGFHPLNVGYLHSGINQGFIPCTALGCLAVIKKYAPNLNGKDAVIVGRSNIVGKPLSALLLKENCSVTICHSKTCNLSSITSKADIVVVAIGSPLKLTAEYFNPESIVIDVGINRISNNKIIGDVDFENVKSKVKYITPVPGGIGPMTIAFLLKNTVKAFKNAIAL

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Baumannia cicadellinicola subsp. Homalodisca coagulata

Length

285 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.701 kDa

Sequence

MVAQIIDGKKIAQQIKSEVAHLVQMRIKAGDAAPCLAVVLVGHDSASQMYVTSKRKTCESIGFISLAYDLPNNVSETELLMLIDQLNTNHSVDGILIQLPLPVGIDNIRVLEQIAPHKDVDGFHPYNLGRLCQRAPLLRPCTPRGVITLLERYNINIVGLNAVVVGASNIVGRPMGMELLLAGCTVTITHRFTRNLQQHVQNADLLVVAVGKAGFIPGSWIKSGAIVIDIGINCLDNGKVVGDVNFSEAIERAAYITPVPGGVGPMTVATLIQNTLQACKYRKLS

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Edwardsiella ictaluri (strain 93-146)

Length

285 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.47 kDa

Sequence

MAAKIIDGKTIARQVRSEVAARVRQRLADGKRAPGLAVIMVGDDPASRIYVGSKQRACEEVGFLSRSYALPDSTDEAQLLALIDTLNADAAIDGILVQLPLPAGIDNSRVLERIHPDKDVDGFHPYNLGRLCQRTPKLRPCTPRGIITLLERCGIETQGMDAVMVGASNIVGRPMALELLLAGCTTTITHSRTRNLQQHVERADLIVAAVGKPGFIPGEWVKPGAVVIDVGINRLESGKVVGDVDFTGAAQRASWITPVPGGVGPMTVATLMQNTLQACEAFHDD

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Photobacterium phosphoreum

Length

285 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.776 kDa

Sequence

MSAQIIDGKIISQTVRQEVAARVKARTDAGLRAPGLAVVLVGQDPASQIYVGSKRKACEEVGFISKSFDLPSSASEQQLLDLIDELNQDPTMDGILVQLPLPAGMDCTRILERIDPEKDVDGFHPYNVGRLSQRIPKLRSCTPKGIITLLERYNIEVRGKHAVIVGASNIVGRPMTLELLLAGATTTTCHRFTQDLEGHIRQADILVVAVGKPNFIPGGWIKEGATVIDVGINRLENGKLCGDVEFDVACQRAKYITPVPGGVGPMTVASLIENTLLACEQYHSA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Photobacterium profundum (strain SS9)

Length

285 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.915 kDa

Sequence

MAAQIIDGKLIAQTVRQEVAARVKARVEAGLRAPGLAVVLVGQDPASQIYVSSKRKACEEVGFISQSFDLPANTKEIELLALINELNTNKEIDGILVQLPLPAGIDTTNILEHIDPEKDVDGFHPYNVGRLSQRIPKLRSCTPKGIITLLERYNIPVRGKHAVIVGASNIVGRPMTLEMLLAGATTTTCHRFTQDLEHHIRQADILVVAVGKPHFIPGDWIKEGATVIDVGINRLDSGKLAGDVEYDVAREKAKYITPVPGGVGPMTVATLIENTLLACEQYHSD

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Sulfurihydrogenibium sp. (strain YO3AOP1)

Length

285 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.301 kDa

Sequence

MILLDGKSLAEKIKNQIKQEIDQLTQKGYRQPVLSVILVGENPASQIYVNKKIKDCASVGIKSKPFFLPENITQTELLELIGDLNGDEEVDGILVQLPLPSHINTLEIIEAINPYKDVDGFHPINVGKLATGRNDAILPCTPYGIMKLLHEYNIDHFGKDVVVVGASNIVGKPMSLLFLKDEKSTVTICHKNTKDLKSHTLKADILVVAVGKPKLITEDMVKEGAVVIDVGINRVDGKIVGDVDFENVKKKAYAITPVPGGVGPMTVAMLLYNTLEIYKRKLIEI

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Brevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.276 kDa

Sequence

MAATILQGKEVAQSIRAELANEVVELKKQGVVPGLTVVIVGDDPASHSYVRGKAKGCEEVGISSEIIRKDADITEEELLVIIQQLNENPNVNGILVQLPLPAHISEHAVIEAIAPEKDVDGFHPISIGNMVLGNDTMLPCTPHGIIELIKRTGTQMAGKHAVVIGRSNIVGKPVSLLLQQENATVTMCHSRTQNLEEYTQKADILVVATGRAHMIGKEHVKPGAVVIDVGVNRIETGKLVGDVKFDEVKDVASFITPVPGGVGPMTITMLLKNTVAAAKKQAKQ

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Haemophilus parasuis serovar 5 (strain SH0165)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.833 kDa

Sequence

MSAQIISGNKLAQQIKTQIFEHIASYVQQGYRAPGLAVILVGSDPASQVYVGSKRKTCAELGIYSESYDLPADTTETQLLSLINKLNNDEKIDGILVQLPLPEHVDTTKIIEAISPDKDVDGFHPYNVGRLCQRIPTLRACTPYGVMKLLETTGENLYGKHAVIVGASNIVGRPMALELLLGGCTVTITHRFTKNLENHVRQADLLVVAVGQPNLIPGEWIKENAIVIDVGINRIGGKLVGDVEYEAASQKAKFITPVPGGVGPMTVAMLMQNTLLAYQRHINP

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.549 kDa

Sequence

MTAQLIDGKAIAANLRQQIAQRVTERRQQGLRVPGLAVILVGTDPASQVYVAHKRKDCEEVGFLSQAYDLPAETSQDDLLALIDRLNDDPAIDGILVQLPLPAHLDASLLLERIHPDKDVDGFHPYNIGRLAQRMPLLRPCTPKGIMTLLASTGADLYGMDAVVVGASNIVGRPMALELLLGGCTVTVTHRFTRDLADHVSRADLVVVAAGKPGLVKGEWIKEGAIVIDVGINRQADGRLVGDVEYEVAAQRASWITPVPGGVGPMTRACLLENTLHAAEHLHD

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Pseudomonas entomophila (strain L48)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.594 kDa

Sequence

MTAHLIDGKAIAANLRQQIAQRVAERRQQGLRTPGLAVILVGTDPASQVYVSHKRKDCEEVGFISQAFDLPSDTTQQALTDLIDRLNDDPAVDGILLQLPLPAHLDASLLLERIRPDKDVDGFHPYNIGRLAQRIPLLRPCTPKGIMTLLESTGQDLYGMNAVIVGASNIVGRPMAMELLLAGCTVTVCHRFTKDLAGHVGRADLVVVAAGKPGLVKGEWVKEGAIVIDVGINRQEDGKLVGDVVYETALPRAGWITPVPGGVGPMTRACLLENTLYAAEELHK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.432 kDa

Sequence

MTAQLIDGKAIAASLRQQIAKRVAERRQQGLRTPGLAVILVGSDPASQVYVSHKRKDCEEVGFLSQAYDLPANTTQEDLAGLIDRLNDDPNIDGVLLQLPLPEHLDASLLLERIRPDKDVDGFHPYNVGRLAQRIPLLRPCTPKGIMTLLESTGADLYGMDAVVVGASNIVGRPMAMELLLAGCTVTVTHRFTKDLAGHVGRADLVVVAAGKPGLVKGEWIKEGAIVIDVGINRQDDGKLVGDVVYETALPRAGWITPVPGGVGPMTRACLLENTLYAAESLHS

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Pseudoalteromonas haloplanktis (strain TAC 125)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.602 kDa

Sequence

MTANIIDGKAIAKQVRSAVAQRVSERVAQNLRAPGLAVVLVGLDPASQVYVGSKRKACEEVGFISKSFDLPANTTEQTLLELIDELNNDQEIDGILVQLPLPEGLDVEKILERITPHKDVDGFHPYNIGRLAQRMPALRPCTPKGIITLLDSTGVRYKGLHAVVVGASNIVGRPMALELLLAGCTTTVCHKFTQDLETHVRRADLLVVAVGKPEFIPGDWVKEGAIVIDVGINRLDSGKLVGDVEYSVAEQKADFITPVPGGVGPMTVASLIENTLEACEKYHS

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.623 kDa

Sequence

MTAHLIDGKAIAASLRQQIAQRVVERRQQGLRTPGLAVILVGTDPASQVYVSHKRKDCEEVGFISQAFDLPSETTQQALTELIDRLNDDPAVDGILLQLPLPAHLDASLLLERIRPDKDVDGFHPYNIGRLAQRIPLLRPCTPKGIMTLLESTGQDLYGMNAVIVGASNIVGRPMAMELLLAGCTVTVCHRFTKDLAGHVGRADLVVVAAGKPGLVKGEWVKEGAIVIDVGINRQEDGKLVGDVVYETALPRAGWITPVPGGVGPMTRACLLENTLYAAEELHK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Pseudomonas fluorescens (strain Pf0-1)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.507 kDa

Sequence

MTAQLIDGKSIAASLRQQIAQRVAERRQQGLRTPGLAVILVGSDPASQVYVSHKRKDCEEVGFLSQAYDLPSETTQEALTDLIDRLNDDPAIDGVLLQLPLPEHLDASKLLERIRPDKDVDGFHPYNVGRLAQRIPLLRPCTPKGIMTLLESTGADLYGMDAVVVGASNIVGRPMAMELLLAGCTVTVTHRFTKDLAGHVGRADLVVVAAGKPGLVKGEWIKEGAIVIDVGINRQEDGKLVGDVVYETALPRAGWITPVPGGVGPMTRACLLENTLYAAETLHA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Pseudomonas putida (strain W619)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.681 kDa

Sequence

MTAHLIDGKAIAANLRKQIAQRVEERRQQGLRTPGLAVILVGTDPASQVYVSHKRKDCEEVGFISQAFDLPSETTQQALTELIDRLNDDPAVDGILLQLPLPAHLDASLLLERIRPDKDVDGFHPYNIGRLAQRIPLLRPCTPKGIMTLLESTGQDLYGMNAVIVGASNIVGRPMAMELLLAGCTVTVCHRFTKDLAGHVGRADLVVVAAGKPGLVKGEWVKEGAIVIDVGINRQEDGKLVGDVVYETALPRAGWITPVPGGVGPMTRACLLENTLYAAEELHK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Pseudomonas stutzeri (strain A1501)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.679 kDa

Sequence

MTAKLIDGKTIAANIRQQISGRVAERRAQGLRAPGLAVILVGSDPASQVYVAHKRKDCEEVGFNSVAHDLPSDTRQEDLLALIDQLNDDASIDGILVQLPLPKHLDASQLFERIRPDKDVDGFHPYNVGRLAQRMPLLRPCTPKGIMTLLESTGVDLHGLDAVVVGASNIVGRPMALELLLAGCTTTVTHRFTRNLAEHVRRADLVVVATGITGLVKGEWIKPGAIVIDVGINRQTDGRLLGDVEFEPASERAAWITPVPGGVGPMTRACLLENTLYAAEHLHD

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Alteromonas mediterranea (strain DSM 17117 / CIP 110805 / LMG 28347 / Deep ecotype)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.666 kDa

Sequence

MTAHLIDGKLIAKQVRQHVTSYVDSLTQAGKRQPGLAVVLVGSDAASQVYVSNKRKACDEVGFVSRSFDLPSDTTEETLLNLVDQLNEDKEIDGILVQLPLPAGLNAEKVLERIHPHKDVDGFHPYNIGRLAQRIPALRPCTPKGIMTMIESTKRPVKGLDAVIVGASNIVGRPMSLELLLAGCTVTTCHKFTQDLKSHVQRADLLVVAVGKPNFIPGDWVKPGAIVIDVGINRVNDGSLVGDVDFDKAKERAGWITPVPGGVGPMTVASLIENTLEAYVKYHS

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Azotobacter vinelandii (strain DJ / ATCC BAA-1303)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.471 kDa

Sequence

MTAKLIDGKAIAASLRQQIAQCVAERRQQGLRAPGLAVILVGTDPASQVYVSHKRKDCEEVGFHSRAYDLPASTTQGELLSLIDRLNEDSAIDGILVQLPLPVHLDASLLLERIRPDKDVDGFHPYNIGRLAQRMPLLRPCTPKGIMTLLQSTGANLYGLDATVVGASNIVGRPMALELLLAGCTVTVTHRFTRNLAEHVSRADLVIAAAGKPGLVKGEWIKPGAIVIDVGINRLDDGRLVGDVEFSSAAARAEWITPVPGGVGPMTRACLLENTLHAAEQLHR

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Corynebacterium aurimucosum (strain ATCC 700975 / DSM 44827 / CN-1)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.476 kDa

Sequence

MSATKLDGNLYRDEIFEDLAQRVAALKEKGITPGLATVLVGDDPGSHSYVKMKHRDCEKLGINSIRKDLPADVSQEELERVIEELNNDDACTGYIVQLPLPKHLDENRVLELIDPAKDADGLHPINLGKLVLNEEAPLPCTPNGCIHLLRRFGVELDGAKVVIIGRGVTVGRPIGLMLTRRSENSTVTLCHTGTKDLAAETREADVIIAAAGKAHMLTADMVKEGAAVLDVGVSRVDGKLAGDVAEDVWEKAGYVSPNPGGVGPLTRAFLVSNIVERAEKLAAQ

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.134 kDa

Sequence

MTAIKLDGNLYRDEIFADLAQRVAALKEKGIVPGLATVLVGDDPASHSYVKMKHRDCEQIGVNSIRRDLPADISQEELFAVIDELNADDSCTGYIVQLPLPKHLDENAVLERIDPAKDADGLHPVNLGKLVLNEPAPLPCTPNGSISLLRRFGIELNGAKVVVIGRGVTVGRPIGLMLTRRSENSTVTLCHTGTKDLAAETRAADVIVAAAGQPHMLTADMVKPGAAVLDVGVSRKDGKLLGDVHPDVWEVAGAVSPNPGGVGPLTRAFLVHNVVERAEKLAGL

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Corynebacterium glutamicum (strain R)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.15 kDa

Sequence

MTAIKLDGNLYRGEIFADLEQRVAALKEKGIVPGLATVLVGDDPASHSYVKMKHRDCEQIGVNSIRKDLPADVTQEELFAVIDELNNDDSCTGYIVQLPLPKHLDENAVLERIDPAKDADGLHPVNLGKLVLNEPAPLPCTPNGSISLLRRFGVELDGAKVVVIGRGVTVGRPIGLMLTRRSENSTVTLCHTGTKDLAAETRAADVIIAAAGQPHMLTADMVKPGAAVLDVGVSRKDGKLLGDVHPDVWEVAGAVSPNPGGVGPLTRAFLVHNVVERAEKLAGL

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.15 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Mycoplasma capricolum subsp. capricolum (strain California kid / ATCC 27343 / NCTC 10154)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.622 kDa

Sequence

MVILDGKLVSKTRKQLVKQQIDIYLNKGYRKPKLAVILIGNDQASELYVSNKIKACNLVGIESMLLRFDENINSQTLSDQINQLNNDQLVDAILLQLPLPKHLNEQMFLQAITPLKDVDGFHYINQGKMLEGYDTIYPCTPIGIINLLKAYNVDVKSKDITIIGTSNIVGKPLAIMLSNMGATVSMCNKNTKSLKKYTKISDIVISATGKQFIITKDMIKKNAIVIDVGIIRDPITNKIVGDVDFENVKELCSYITPVPGGVGPMTVAMLLENTLQLYKKHIKE

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Shewanella frigidimarina (strain NCIMB 400)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.428 kDa

Sequence

MTAQIIDGKAIAQSIRTTLKQKVTQRRQAGFRAPGLAVILVGSDAASQVYVGSKRKACEEVGFESQSFDLDTETTEAELLALIDECNANPSIDGILVQLPLPAHIDDSKVIERIRPDKDVDGFHPYNVGRLAQRIPVLRSCTPMGIMTLIKSTGIDTYGLDATVVGASNIVGRPMTLELLLAGCTTTTCHRFTKNLEQKVRQADLLVVAVGKPGFIPGDWIKPGAIVIDVGINRLENGSLVGDVEFNVAAEKAAFITPVPGGVGPMTIASLLENTLYACEQYHS

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Shewanella halifaxensis (strain HAW-EB4)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.555 kDa

Sequence

MTAQIIDGKAIAQTIRTQLKDKVTARKEAGQRAPGLAVILVGADPASQVYVGSKRRACEEVGFISRSYDLDSSTSEEALLSLIDECNEDPSIDGILVQLPLPEHIEESKVIERIRPDKDVDGFHPYNVGRLAQRIPVLRACTPMGIMTLIKSTGVDTFGLDAVVIGASNIVGRPMALELLLTGCTTTICHRFTRNLEDKVRQADLLVVAVGKPGFIPGDWIKPGAIVIDVGINRLEGGQLVGDVQFDDAAQHASFITPVPGGVGPMTIASLLENTLYACEQYHD

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Shewanella loihica (strain ATCC BAA-1088 / PV-4)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.555 kDa

Sequence

MTAQIIDGKAIAQSIRKQLSAKVTARKEAGKRVPGLAVILVGADPASQVYVGSKRRACEEVGFLSQSFDLPTETSEADLLALIDKCNEDPSIDGILVQLPLPDHIEESKVIERIRPDKDVDGFHPYNVGRLAQRIPVLRSCTPMGIMTLIKSTGVDTYGLDAVVVGASNIVGRPMTLELLLAGCTTTTCHRFTRDLEDKVRRADLLIVAVGKPNFIPGEWIKPGAIVIDVGINRLESGQLVGDVQYDVAAEHASHITPVPGGVGPMTIASLLENTLYAAENYHD

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Shewanella oneidensis (strain MR-1)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.502 kDa

Sequence

MTAQIIDGKAIAQSIRTQLREQVTARKEAGQRVPGLAVILVGADPASQVYVGSKRKACEEVGFISRSYDLDTSCSEAELLALIDQLNDDPSIDGILVQLPLPAHIEDSKVIERIRPDKDVDGFHPYNVGRLAQRIPVLRSCTPMGIMTLIKSTGVDTYGLDAVVVGASNIVGRPMTLELLLAGCTTTTCHRFTKNLEQKIRQADLVVVAVGKPGFIPGEWIKPGAIVIDVGINRLENGTLVGDVQYETAAQNASFITPVPGGVGPMTIASLLENTLYAAEQYHD

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Shewanella pealeana (strain ATCC 700345 / ANG-SQ1)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.494 kDa

Sequence

MTAQNIDGKAIAQSIRTQLKDKVTARKEAGKRVPGLAVILVGADPASQVYVGSKRKACEEVGFISRSYDLDSSTSEDALLSLIDECNEDPTIDGILVQLPLPEHIEESKVIERIRPDKDVDGFHPYNVGRLAQRIPVLRSCTPMGIMTLLKSTGVDTFGLDAVVVGASNIVGRPMSLELLLAGCTTTTCHRFTRNLEDKVRSADLVVVAVGKPGFIPGDWIKPGAIVIDVGINRLESGQLVGDVEFDVASQHASFITPVPGGVGPMTIASLLENTLYACEQYHD

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Shewanella putrefaciens (strain CN-32 / ATCC BAA-453)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.504 kDa

Sequence

MTAQIIDGKAIAQSIRTKLSEKVTARKEAGQRVPGLAVILVGADPASQVYVGSKRKACEEVGFISRSYDLETNCTEDELLNLIDSLNDDPTIDGILVQLPLPAHIEDSKVIERIRPDKDVDGFHPYNVGRLAQRIPVLRSCTPMGIMTLIKSTGVDTYGLDAVVVGASNIVGRPMTLELLLAGCTTTTCHRFTKNLEQKIRQADLVVVAVGKPGFIPGEWIKPGAIVIDVGINRLDNGTLVGDVQYEAAAQNASFITPVPGGVGPMTIASLLENTLYAAEQYHD

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Shewanella sp. (strain ANA-3)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.575 kDa

Sequence

MTAQIIDGKAIAQSIRTQLREKVTARKEAGQRVPGLAVILVGADPASQVYVGSKRKACEEVGFISRSYDLDTSYTEEALLALIDELNDDPTIDGILVQLPLPAHIEDSKVIERIRPDKDVDGFHPYNVGRLAQRIPVLRSCTPMGIMTLIKSTGVDTYGLDAVVVGASNIVGRPMTLELLLAGCTTTTCHRFTKNLEQKIRQADLVVVAVGKPGFIPGEWIKPGAIVIDVGINRLENGTLVGDVQYDVAAQNASFITPVPGGVGPMTIASLLENTLYAAEQYHD

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Shewanella sediminis (strain HAW-EB3)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.62 kDa

Sequence

MTAQRIDGKAIAQSIRTQLKEKVTARKEAGQRVPGLAVILVGADPASQVYVGSKRRACEEVGFLSRSYDLDTTTSEAELLTLIDECNEDPAIDGILVQLPLPEHIEESKVIERIRPDKDVDGFHPYNVGRLAQRIPVLRSCTPMGIMTLIKTTGIDTYGLDAVIVGASNIVGRPMSLELLLAGCTTTTCHRFTRNLEQKVRQADLLVVAVGKPGFIPGEWIKPGAIVIDVGINRLEDGSLAGDVQFDAASENASFITPVPGGVGPMTIASLLENTLYAAEQYHD

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Shewanella sp. (strain MR-4)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.575 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Shewanella sp. (strain MR-7)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.589 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Shewanella sp. (strain W3-18-1)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.463 kDa

Sequence

MTAQIIDGKAIAQSIRTKLSEKVTARKEAGQRVPGLAVILVGADPASQVYVGSKRKACEEVGFISRSYDLETNCSEDELLSLIDSLNDDPTIDGILVQLPLPAHIEDSKVIERIRPDKDVDGFHPYNVGRLAQRIPVLRSCTPMGIMTLIKSTGVDTYGLDAVVVGASNIVGRPMTLELLLAGCTTTTCHRFTKNLEQKIRQADLVVVAVGKPGFIPGEWIKPGAIVIDVGINRLDNGTLVGDVQYEAAAQNASFITPVPGGVGPMTIASLLENTLYAAEQYHD

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Alteromonas mediterranea (strain DSM 17117 / CIP 110805 / LMG 28347 / Deep ecotype)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.666 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Azotobacter vinelandii (strain DJ / ATCC BAA-1303)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.471 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Corynebacterium aurimucosum (strain ATCC 700975 / DSM 44827 / CN-1)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.476 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.134 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Corynebacterium glutamicum (strain R)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.15 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.15 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Mycoplasma capricolum subsp. capricolum (strain California kid / ATCC 27343 / NCTC 10154)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.622 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Shewanella frigidimarina (strain NCIMB 400)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.428 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Shewanella halifaxensis (strain HAW-EB4)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.555 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Shewanella loihica (strain ATCC BAA-1088 / PV-4)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.555 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Shewanella oneidensis (strain MR-1)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.502 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Shewanella pealeana (strain ATCC 700345 / ANG-SQ1)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.494 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Shewanella putrefaciens (strain CN-32 / ATCC BAA-453)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.504 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Shewanella sp. (strain ANA-3)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.575 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Shewanella sediminis (strain HAW-EB3)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.62 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Shewanella sp. (strain MR-4)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.575 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Shewanella sp. (strain MR-7)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.589 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Shewanella sp. (strain W3-18-1)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.463 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Natranaerobius thermophilus (strain ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.885 kDa

Sequence

MSASLIKGSDVAKEIRSDLQKDVEDLKSQGVTPHLAVVLVGEDSASQTYVNMKEKTAGKVGIESTVKRLPTNVEEDELLRLIDELNKDDSVHGILVQLPLPYHIDEYKILNAIDQYKDVDSFHPVNVGNLTIGQKRFTPCTPAGIMKLLDSIDYDLNGKHAVVLGRSNIVGKPISLLLLERNATVSICHSRTKDLTEMTKSADLLIVAVGRPEIVTGKMIKPGAVVIDVGVNKVDDKLIGDVEFESAKEVAGWITPVPGGVGPMTITMLLNNTIEAARRCLNEQ

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Nautilia profundicola (strain ATCC BAA-1463 / DSM 18972 / AmH)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.988 kDa

Sequence

MTILDGKKLSEKIKDNLKKEVDELKTKGITPGLAVILVGDDPASHTYVKMKRNACQKVGIYSVVHEFPESITEKELLSTIKMINENPNIHGLLIQLPLPKHIDTTKILEAVDPSKDVDGFHPYNMGRLVEGLDTFAPCTPLGVMEIFEEYEIDLKGKDVCVVGASNIVGKPMWALLVNAWATVDICHIETKDLAAHTKRADIVIVGVGKPNLITADMVKDGVIVIDIGINRLEDGRLVGDVDFENVSKKASYITPVPGGVGPMTIAMLLKNTVKAAKNFAKEVK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.001 kDa

Sequence

MSAQLINGKEVSQKHLQAIAEAVAQRQQDNLHTPCLAVVLVGGDPAGAVYVRNKKTACQKCGIKSLSYELPESTSQEELLALVDRLNADSEVDGILVQLPLPKHLDSQAILERISPDKDVDGFHPYNVGRLAVKMPLMRPCTPKGVMTLLEAYGIDPKGKKAVVVGASNIVGRPQALELLLARATVTVCHSATENLADEVAAADILVVGVGIPNFVKGGWIKPGAVVIDVGINRLDDGSLCGDVEFETAKERAAMITPVPGGVGPMTIATLMENTLHAASLHDA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Neisseria gonorrhoeae (strain NCCP11945)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.001 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Neisseria meningitidis serogroup C (strain 053442)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.11 kDa

Sequence

MSAQLINGKEVSQKRLQAVAEAVAQRQQDNLHMPCLAVVLVGGDPASAVYVRNKKTACQKCGIKSLSYELPESTSQEELLALVDRLNADSEVDGILVQLPLPKHLDSQAVLERISPDKDVDGFHPYNVGRLAVKMPLMRPCTPKGVMTLLEAYGIDPKGKKAVVVGASNIVGRPQALELLLARATVTVCHSATENLADEVAGADILVVGVGIPNFVKGEWIKPGAVVIDVGINRLDDGSLCGDVEFETAKERAAMITPVPGGVGPMTIATLMENTLHAASLHDA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.14 kDa

Sequence

MSAQLINGKEVSQKRLQAVAEAVAQRQQDNLHMPCLAVVLVGGDPASAVYVRNKKTACQKCGIKSLSYELPESTSQEELLALVDRLNADSEVDGILVQLPLPKHLDSQAVLERISPDKDVDGFHPYNVGRLAVKMPLMRPCTPKGVMTLLEAYGIDPKGKKAVVVGASNIVGRPQALELLLARATVTVCHSATENLTDEVAGADILVVGVGIPNFVKGEWIKPGAVVIDVGINRLDDGSLCGDVEFETAKERAAMITPVPGGVGPMTIATLMENTLHAASLHDA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Neisseria meningitidis serogroup B (strain MC58)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.145 kDa

Sequence

MSAQLINGKEVSQKRLQAVAEAVAQRQQNNLHHPCLAVVLVGGDPASAVYVRNKKTACQKCGIKSLSYELPESTSQEELLALVDRLNADSEVDGILVQLPLPKHLDSQAVLERISPDKDVDGFHPYNVGRLAVKMPLMRPCTPKGVMTLLEAYGIDPKGKKAVVVGASNIVGRPQALELLLARATVTVCHSATENLTDEVAGADILVVGVGIPNFVKGEWIKPGAVVIDVGINRLDDGSLCGDVEFETAKERAAMITPVPGGVGPMTIATLMENTLHAASLHDA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Neisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / DSM 15464 / FAM18)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.123 kDa

Sequence

MSAQLINGKEVSQKRLQAVAEAVAQRQQNNLHTPCLAVVLVGGDPASAVYVRNKKTSCQKCGIKSLSYELPESTSQEELLALVDRLNVDSEVDGILVQLPLPKHLDSQAVLERISPDKDVDGFHPYNVGRLAVKMPLMRPCTPKGVMTLLEAYGIDPKGKKAVVVGASNIVGRPQALELLLARATVTVCHSATENLADEVAGADILVVGVGIPNFVKGEWIKPGAVVIDVGINRLDDGSLCGDVEFETAKERAAMITPVPGGVGPMTIATLMENTLHAASLHDA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Streptococcus pyogenes serotype M12 (strain MGAS9429)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.096 kDa

Sequence

MTELIDGKALAQKMQQELAAKVNNLKQKKGIVPGLAVILVGDDPASQVYVRNKERAALTVGFKSETVRLSEFICQEELIAVIERYNADNTIHGILVQLPLPNHINDKKIILAIDPKKDVDGFHPMNTGHLWSGRPLMVPCTPSGIMELLREYNVNLEGKHAVIIGRSNIVGKPMAQLLLDKNATVTLTHSRTRQLEEVCRCADVLIVAIGQGHFITKQYIKEGAIVIDVGMNRDDNGKLIGDVAFDEVAEVAAKITPVPGGVGPMTIAMLLEQTYQSALRSTHK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Streptococcus pyogenes serotype M2 (strain MGAS10270)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.096 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Streptococcus pyogenes serotype M4 (strain MGAS10750)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.096 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Streptococcus pyogenes serotype M5 (strain Manfredo)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.096 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Streptococcus pyogenes serotype M28 (strain MGAS6180)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.082 kDa

Sequence

MTELIDGKALAQKMQQELAAKVNNLKQKKGIVPGLAVILVGDDPASQVYVRNKERAALTVGFKSETVRLSEFICQEELIAVIERYNADNTIHGILVQLPLPNHINDKKIILAIDPKKDVDGFHPMNTGHLWSGRPLMVPCTPSGIMELLREYNVNLEGKHAVIIGRSNIVGKPMAQLLLDKNATVTLTHSRTRQLEEVCRCADVLIVAIGQGHFITKQYIKDGAIVIDVGMNRDDNGKLIGDVAFDEVAEVAAKITPVPGGVGPMTIAMLLEQTYQSALRSTHK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Streptococcus pyogenes serotype M3 (strain SSI-1)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.096 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Streptococcus pyogenes serotype M49 (strain NZ131)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.096 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Streptococcus equi subsp. zooepidemicus (strain H70)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.871 kDa

Sequence

MVQIIDGKALAQKMQAALAKKVESLKAEKGIVPGLVVILVGDNPASQVYVRNKERAALAAGFKSETVRLSDSVCQEELIELIEQYNQDDTIHGILVQLPLPHHINDKSIILAIDPKKDVDGFHPMNTGHLWSGRPNMVPCTPAGIMEMFHDYGIELEGKNAVIVGRSNIVGKPMAQLLLDKNATVTLTHSRTRQLAAICRRADILIVAIGQGHFITKDFVKEGAVVIDVGMNRDVNGRLIGDVAFDEVSELASMITPVPGGVGPMTITMLLEQTYQAALRRVSQ

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Streptococcus sanguinis (strain SK36)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.021 kDa

Sequence

MAQIIDGRGLAEKLQKKLAEKTARLKEKTGQVPGLVVIVVGNNPASQIYVRNKERSALAAGFRSKVERLPEETSQEELLSLIETYNQNPDWHGILVQLPLPEHIDDEAVLLAIDPDKDVDGFHPLNMGKLWSGHPVMIPATPAGIMAMFHEYGIELEGKRAVVIGRSNIVGKPMAQLLLAKNATVTLTHSRTHNLAKTAKRADILVVAIGRGHFVTKNFVKEGAVVIDVGMNRDENGKLIGDVKFDEVAEIASLITPVPGGVGPMTITMLMEQTYQAFKRSLES

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Streptococcus thermophilus (strain CNRZ 1066)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.383 kDa

Sequence

MAIIMDGKALAVNMQEQLQEKVARLKEKEWIVPGLVVIMVGENPASQVYVRNKERAAKKAGFHSKTVNLSESISEEELIEVIEKYNQNPLFHGILVQLPLPNHINEMRILLAIDPKKDVDGFHPMNTGNLWNGRPQMVPCTPAGIMEILREYNVELEGKTAVIIGRSNIVGKPMAQLLLEKNATVTLTHSRTPHLAKVCNKADVLIVAIGRAKFVTEEFVKEGAVVIDVGINRDEEGKLCGDVDFDQVKEKVSMITPVPGGVGPMTITMLMEQTYQAALRSLKG

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.357 kDa

Sequence

MAIIMDGKALAVNMQEQLQEKVARLKEKEWIVPGLVVIMVGENPASQVYVRNKERAAKKAGFHSKTVNLSESISEEELIEVIEKYNQDPLFHGILVQLPLPNHISEMRILLAIDPKKDVDGFHPMNTGNLWNGRPQMVPCTPAGIMEILREYNVELEGKTAVIIGRSNIVGKPMAQLLLEKNATVTLTHSRTPHLAKVCNKADVLIVAIGRAKFVTEEFVKEGAVVIDVGINRDEEGKLCGDVDFDQVKEKVSMITPVPGGVGPMTITMLMEQTYQAALRSLKG

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Streptococcus thermophilus (strain ATCC BAA-491 / LMD-9)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.37 kDa

Sequence

MAIIMDGKALAVNMQEQLQEKVARLKEKEWIVPGLVVIMVGENPASQVYVRNKERAAKKAGFHSKTVNLSESISEEELIEVIEKYNQDPLFHGILVQLPLPNHINEMRILLAVDPKKDVDGFHPMNTGNLWNGRPQMVPCTPAGIMEILREYNVELEGKTAVIIGRSNIVGKPMAQLLLEKNATVTLTHSRTPHLAKVCNKADVLIVAIGRAKFVTEEFVKEGAVVIDVGINRDEEGKLCGDVDFDQVKEKVSMITPVPGGVGPMTITMLMEQTYQAALRSLKG

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Streptococcus thermophilus

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.383 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Streptococcus uberis (strain ATCC BAA-854 / 0140J)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.281 kDa

Sequence

MTQIIDGKALAQKMQSQLAKKVEDLKQEFGIVPGLVVILVGDNPASQVYVRNKERSAIAAGFKSETIRLSESICQEELIKIIHRYNKDESIHGILVQLPLPTHINEKRIILEIDPHKDVDGFHPMNTGHLWSGRPIMVPCTPAGIMEMLSEYQIDLEGKHAVIIGRSNIVGKPMAQLLLDKNATVTLTHSRTRNLSKISSEADVLIVAIGQGHFVTEEYVKEGAVVIDVGMNRDDNGKLIGDVAFEEVSRKASYITPVPGGVGPMTITMLLEQTYQSALRRVSS

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Buchnera aphidicola subsp. Cinara cedri (strain Cc)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.856 kDa

Sequence

METKILDGLKISKKIIKKIKKKIEKRKKKRKKIPGLAMIVIGNNPASLIYVNKKREACNQAGFFSIYWHLSNQIEEIELINLIKKLNKNKCIDGILIQLPLPIKINYLKIITSIDPKKDVDGFHPYNLGSLCQNNPQFRSCTSKGVITLLKKYKINIHGLYAVIIGSSNIVGKPMYMELLLAGCTVTIVNKNTKNIKTYVKKADLVVIAIGQPNFLYGHWIKLGAIVIDIGINYLYNKNKYKIVGDVHFKSTSVKTSYITPVPGGVGPMTVVSLLENTLQACIM

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Burkholderia vietnamiensis (strain G4 / LMG 22486)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.813 kDa

Sequence

MTALLIDGNALSKTLRAQAAERAAALTARGHQPGLAVILVGANPASEVYVRNKIKACEDNGFFSLKDAYPDTLSEADLLARIDELNRDPKIHGILVQLPLPAHIDSHKVIEAIAPEKDVDGFHVANAGALMTGKPLFRPCTPYGVMKMFEAHDIPLQGANAVVIGRSNIVGKPMAMLLLEAGATVTICHSKTRDLAAHTRQADIVVAAVGKRNILTADMVKPGATVIDVGMNRDDAGKLCGDVDFAGVKDVAGHITPVPGGVGPMTITMLLINTIEAAERAATA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Geobacillus kaustophilus (strain HTA426)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.141 kDa

Sequence

MTAQIISGTEMARTIRTALADEAAQLKADGVEPGLAVILVGDDPASHSYVKGKQKACAEVGIRSFLYTFPAAIDEETLLAKIRELNVDPAVHGILVQLPLPDHICEWSVIETIAPEKDVDGFHPINVGKMMIGQRAFLPCTPHGILVMVQSAGIDIAGKHVVVVGRSNIVGKPVGQLFLREHATVTYTHSKTPDLAAITRQADILIVAVGKARLIGPEHIKPGAVVIDVGVNRLENGKLCGDVDFDAVKEVAGYITPVPGGVGPMTITMLLHNTIEAARQLAAK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Geobacillus thermodenitrificans (strain NG80-2)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.033 kDa

Sequence

MTAQIISGTELAKTIRAELADEVAKLKANGIEPGLAVILVGDDPASHSYVKGKQKACAEVGIRSLLYTFPATISEEELLAKIQELNADPTVHGILVQLPLPAHIREWSVIETIAPEKDVDGFHPINVGKMMIGQPAFLPCTPHGVLVMVKSAGIDIAGKHVVVVGRSNIVGKPVGQLFLREHATVTYAHSKTPDLAAITRQADILIVAVGKARLIGPEHVKPGAVVIDVGVNRLESGKLCGDVDFDAVKEVASYVTPVPGGVGPMTITMLLHNTMEAARQLAAK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Pseudomonas aeruginosa (strain PA7)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.519 kDa

Sequence

MTAQLIDGKAIAANLRQQIAQRVTERRQQGLRVPGLAVILVGTDPASQVYVAHKRKDCEEVGFLSQAYDLPADTSQDELLALIDRLNDDPAIDGILVQLPLPAHLDASLLLERIHPDKDVDGFHPYNIGRLAQRMPLLRPCTPKGIMTLLASTGADLYGMDAVVVGASNIVGRPMALELLLGGCTVTVTHRFTRDLAAHVSRADLVVVAAGKPGLVKGEWIKEGAIVIDVGINRQADGRLVGDVEYDVAARRASWITPVPGGVGPMTRACLLENTLHAAEHLHD

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Pseudomonas aeruginosa (strain LESB58)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.549 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Pseudomonas aeruginosa (strain UCBPP-PA14)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.549 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Thiobacillus denitrificans (strain ATCC 25259)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.385 kDa

Sequence

MSARILDGKAMADTILAVIHDKVAEREVQGKRRPGLAVILVGGDPASAVYVRNKKRACERAGVNSVSHDLPETTTQPELLALIDTLNSDAAIDGILVQLPLPVHIDAETVIERIRPDKDVDGFHPYNIGRLAVKMPTLRPSTPRGIMTLLRATNEELRGKNAVMVGASNIVGRPMSLELLLAGCTITVCHSATRDLESFVRSAEVLVVGVGRPRMIPGDWVREGAIVIDVGINRLADGKLVGDVDFDTAVERAGWITPVPGGVGPMTVATLLENTLEAALMHNP

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Tolumonas auensis (strain DSM 9187 / TA4)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.313 kDa

Sequence

MSAKIIDGKAIALSVRQRVAARVAERKAKGLRAPGLAVVLVGEDAASQVYVGSKRRACEEVGFISKSYDLAPTITQDELLALIDQLNADPTIDGVLVQLPLPAHLDSTQVIERILPNKDVDGFHPYNVGRLAQRIPALRPCTPKGMMTLLENTGVKIKGMHAVVVGASNIVGRPMTLELLLAGCTTTTCHRFTKGLEQFVRQADILVVAVGKAEFIPGEWIKPGAIVLDVGINRLSNGKLVGDVEYPTAAQHASFITPVPGGVGPMTVATLIENTLQACEQYHS

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Dechloromonas aromatica (strain RCB)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.895 kDa

Sequence

MTAQIIDGKALAEELRQGFKARVEALTAKGHKPGLVVILVGADPASEVYVRNKVNGCLAIGMHSEKITYDATIDQATVLNKIAELNADPNIHGILVQLPLPKHFDEEAVLEAISAEKDVDGFHAENVGALAQGNPRFIPCTPYGVMKMFEKGNVDLTGKEAVVIGRSNIVGKPMALLLINAGATVTVCNSRTKDLKFHTSRADILVAAVGKPKFVTGDMVKPGAVVIDVGINRLPDGKLCGDVDFASCLEVAGQITPVPGGVGPMTITMLLANTIEAAERKAGL

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Delftia acidovorans (strain DSM 14801 / SPH-1)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.729 kDa

Sequence

MTAQLIDGNALSRQLRAEVAQRATALKARGTTPGLAVVLVGDNPASQVYVRNKVKACEDAGFHSVLEKYDASMTEAELLARVEALNNDPSIHGILVQLPLPAHIDDHKVIETISPLKDVDGFHVASAGALMVGEVGFKACTPYGCMKMLESIGMKDLRGKHAVVIGRSNIVGKPMAMMLLAANATVTICHSGTADLAAMTRQADIVVAAVGKRNVLTADMCKPGAVVIDVGMNRNDEGKLCGDVDFDGVKEVAGFITPVPGGVGPMTITMLLVNTMEAAERAAG

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Desulfotomaculum reducens (strain MI-1)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.46 kDa

Sequence

MTKILDGKKIASILREELKQDIITLKERGIEPKLAVVLVGEDPASVAYAKFLQKVSENAGVLFELHQLSKSTAEEEIICKIEDLNQIQAVHGILMMMPLPPHVNKQHIMEHISPLKDVDGLHPFNRGHLISGGICLHPATPTSCLEILKRSGITLAGKHIVVVGRGETVGKPLVFMALAENATVTVCHSRTVDLGKFTKQADIIISAVGKPGLITADMIKPGAVVVDAGIHEEAGNIIGDVDYEQVKEIAEAITPVPGGVGSLTTVLMLKNVLKGIQLQIGTQE

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Nitrosococcus oceani (strain ATCC 19707 / BCRC 17464 / NCIMB 11848 / C-107)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.821 kDa

Sequence

MSANILDGKAIAANIRRNIKKRVQERITAGLRPPGLAVILLGSDPASQVYVRNKRRACEEVGFKSLAYDLPADTTQANLLALIDQLNADSTVDGILVQLPLGGHIDAEQVIEQIRPDKDVDGFHPYNIGRLTLRLPLLRPCTPHGVITLLRTTGQDLRGLEAVVVGASNIVGRPMMLELLLAGCTVTICHRWTRDLHKPISEADIVVAAVGKPHLIQGKWIKPGATVIDVGFTRQPDGTLTGDVEFESARQRALWITPVPGGVGPMTIATLLQNTLYATEKLHE

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Alkaliphilus metalliredigens (strain QYMF)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.237 kDa

Sequence

MGEIIKGKPVADKISEDLIQEIEGLKGKGIQPKLAIVRVGANSSDLAYEKGALGRSKKVGVETEVHELPEDITQDDFIKELKKLNEDKAVNGILIFRPLPEQLDESVIKYVIAPEKDIDCLSPINVGKMTEGDKTGFPPCTPTAVVEILKFYGVELQGKDCAIIGASMVVGKPAALLLLNENATISVCHIFTKDSAKIASQADVVVVGVGVPRLVKENWIANGAVVIDVGINVDKEGNMCGDVDFDGVKDKVSMITPVPGGVGSVTTSILAKHVVKACKQQNNL

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Clostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 / H10)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.018 kDa

Sequence

MSAKVLNGTELAAKVKAGLKAKIDELKSKGINPGLAVIIVGDDPASRVYVNHKKNDCTEIGIKSFEYALPESTSEEELLDLIETLNNDASVNGILVQLPIPKHINEEKVIAAISPDKDADCFHPMNVGKLMIGKPEFLPCTPAGVVELLEENGIEISGKNCVVVGRSNIVGKPQAILLLAKNATVTICHSKTANIEEVCRSADVLVVAIGKSEFIKPEFVKPGAVVIDVGVSRGADGKLVGDVQFAEVAEIASAITKVTGGVGPMTRAMLMKNTYKAVLLQNGL

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.254 kDa

Sequence

MGLIIKGKPVADAISETLIKEVDNFKIQGIIPKLVIIRVGAKASDLAYEKGILKRCNGIGIETYVKEFPEDISQREFIRELRRLNEDRNVDGIMVFRPLPKHLDENIIKYVITPEKDIDCFNPINLAKVIAGDSTGFAPCTPRAVMEILKYYNIDVEGKFSVVIGRSMIVGKPMSMLLLNENSTVTTCHSKTVHLDKICSQADILVAGIGKAEFIDSKYIKEGAVVIDVGINVDKYGKLCGDVDIKSCQWKNVIVTPVPGGVGTVTSSVLAQHVVEACKHKNKL

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.727 kDa

Sequence

MTATIIDGKETAKEKRGQLAKEVEELKKQGVTPGLAVILIGDDPASLSYVRGKKKAAEAMGIRFQLDHFDASFTEQELLEVIDQYNQNDDFHGILVQLPLPDHISEQAVIERISPEKDVDGFHPLNVGKMLLGEDTFLPCTPAGIVELLKKTEIDLSGKEVVVVGRSNIVGKPVGQLLLNENATVTYCHSRTADITAHTKKADILIVAVGKANFIKADQIKEGAVVIDVGVNRLDNGKLAGDVDFEEAKEKASYITPVPGGVGPMTITMLAHNTVKSAKRTIQL

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Streptococcus agalactiae serotype Ia (strain ATCC 27591 / A909 / CDC SS700)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.252 kDa

Sequence

MTELIDGKALSQKMQAELGRKVERLKEQHGIIPGLAVILVGDNPASQVYVRNKERSALEAGFKSETLRLSESISQEELIDIIHQYNEDKSIHGILVQLPLPQHINDKKIILAIDPKKDVDGFHPMNTGHLWSGRPMMVPCTPAGIMEMFREYHVDLEGKHAVIIGRSNIVGKPMAQLLLDKNATVTLTHSRTRNLSEVTKEADILIVAIGQGHFVTKDFVKEGAVVIDVGMNRDENGKLIGDVVFEQVAEVASMITPVPGGVGPMTITMLLEQTYQAALRSVSL

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Streptococcus agalactiae serotype III (strain NEM316)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.252 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.252 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.79 kDa

Sequence

MTAQILDGKATAAAIKSELTARVAALKERGVTPGLGTVLVGDDPGSQKYVAGKHRDCAQVGIASIQRELPATATQEEIEAVVRELNEDPACTGYIVQLPLPRGIDENRILELMDPDKDADGLHPMNLGRLVLNEPAPLPCTPNGILTLLRRYGVEIKGAEVVVVGRGVTIGRPMPLLLTRRSENATVTQCHTGTRDLAAHLKRADIVIAAAGSPHLVRPEDVKPGAAVLDVGVSRNAEGKIMGDVHPGVAEVAAWISPNPGGVGPMTRAQLLVNVVEAAERSAG

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Streptococcus equi subsp. equi (strain 4047)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.957 kDa

Sequence

MVQIIDGKALAQKMQAALAKKVESLKAEKGIVPGLVVILVGDNPASQVYVRNKERAALAAGFKSETVRLSDSVCQEELIELIEQYNQDDTIHGILVQLPLPHHINDKSIILAIDPKKDVDGFHPMNTGHLWSGRPNMVPCTPAGIMEMFHDYGIELEGKNAVIVGRSNIVGKPMAQLLLDKNATVTLTHSRTRRLADICRRADILIVAIGQGHFITKEFVKEGAVVIDVGMNRDVNGRLIGDVAFDEVSELASMITPVPGGVGPMTITMLLEQTYQAALRRVSQ

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Streptococcus equi subsp. zooepidemicus (strain MGCS10565)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.89 kDa

Sequence

MVQIIDGKALAQKMQAALAKKVESLKAEKGIVPGLVVILVGDNPASQVYVRNKERAALAAGFKSETVRLSDSVCQEELIELIEQYNQDDTIHGILVQLPLPHHINDKSIILAIDPKKDVDGFHPMNTGHLWSGRPNMVPCTPAGIMEMFRDYGIELEGKNAVIVGRSNIVGKPMAQLLLDKNATVTLTHSRTRQLAAICRRADILIVAIGQGHFITKDFVKEGAVVIDVGMNRDVNGRLIGDVAFDEVSELASMITPVPGGVGPMTITMLLEQTYQAALRRVSQ

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Streptococcus gordonii (strain Challis / ATCC 35105 / BCRC 15272 / CH1 / DL1 / V288)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.841 kDa

Sequence

MAELIDGKALAAKLQGKLAQKTAKLKEKTGQTPGLVVVLVGNNPASQIYVRNKERSALAAGFRSKVERLPEETSQEELLSLIETYNQNPDWHGILVQLPLPDHIDDEAVLLAIDPDKDVDGFHPLNMGKLWSGHPVMIPATPAGIMAMFHEYGVELEGKRAVVIGRSNIVGKPMAQLLLAKNATVTLTHSRTHNLAKTAKRADILVVAIGRGHFVTKDFVKEGAVVIDVGMNRDENGKLIGDVQFDEVSEIASLITPVPGGVGPMTITMLMEQTYQAFKRSLES

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Streptococcus mutans serotype c (strain ATCC 700610 / UA159)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.932 kDa

Sequence

MTEIIDGKALAQKLQLHLANKVEQMKEKHGLVPGLVVILVGDNPASQVYVRNKERSAIKAGFKSETICLSDSISEEELIEIIEGYNQDPSFHGILVQLPLPAHINDKKIILAIDPHKDVDGFHPMNTGHLWSGRSMMVPCTPAGIMEMLSAYHVDLEGKHAVIIGRSNIVGKPMAQLLLEKNATVTLTHSRTKHLSEVTRCADVLIVAIGQGNFVTEEFVKEGAVVIDVGMNRDKNGKLIGDVNFDHVAQKASLITPVPGGVGPMTITMLLEQTYQAALRSVTK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Streptococcus pyogenes serotype M1

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.082 kDa

Sequence

MTELIDGKALAQKMQQELAAKVNNLKQKKGIVPGLAVILVGDDPASQVYVRNKERAALTVGFKSETVRLSEFICQEELIAVIERYNADNTIHGILVQLPLPNHINDKKIILAIDPKKDVDGFHPMNTGHLWSGRPLMVPCTPSGIMELLREYNVNLEGKHAVIIGRSNIVGKPMAQLLLDKNATVTLTHSRTRQLEEVCRCADVLIVAIGQGHFITKQYIKDGAIVIDVGMNRDDNGKLIGDVAFDEVAEVAAKITPVPGGVGPMTIAMLLEQTYQSALRSTHK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.096 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.096 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Streptococcus pyogenes serotype M18 (strain MGAS8232)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.082 kDa

Sequence

MTELIDGKALAQKMQQELAAKVNNLKQKKGIVPGLAVILVGDDPASQVYVRNKERAALTVGFKSETVRLSEFICQEELIAVIERYNADNTIHGILVQLPLPNHINDKKIILAIDPKKDVDGFHPMNTGHLWSGRPLMVPCTPSGIMELLREYNVNLEGKHAVIIGRSNIVGKPMAQLLLDKNATVTLTHSRTRQLEEVCRCADVLIVAIGQGHFITKQYIKDGAIVIDVGMNRDDNGKLIGDVAFDEVAEVAAKITPVPGGVGPMTIAMLLEQTYQSALRSTHK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Streptococcus pyogenes serotype M12 (strain MGAS2096)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.096 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Campylobacter hominis (strain ATCC BAA-381 / LMG 19568 / NCTC 13146 / CH001A)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.549 kDa

Sequence

MQLIDGKAISAKVKEEVKNEAAQLTEKGVVPCLAVILVGDDKASQTYVNSKEKACKACGIRSLKYTLEANTSESALIDLIQSLNENDEVDGILVQLPLPKHIDENKILEKISCEKDVDGFHAVNVGRLVSGLDGFVPCTPCGIMRLFKEYDIEISGKNAVVIGRSNIVGKPMANLLLNANATVTVTHSKTQNLAKITKDADIIVVAIGKPNFLKADMVKNGAVVIDVGINRLENNKLVGDADFENVANKCSFITPVPGGVGPMTIAMLLKNTIKSAKNRLKRLK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Lactococcus lactis subsp. lactis (strain IL1403)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.14 kDa

Sequence

MNLIDGKALAAKMQAELKVKVDKLKEADNVPGLAVILVGEDPASQIYVRNKARQATAIGLNSSVVRLPETVSEQELLDLIEQYNQSEQWHGILVQLPLPEHISEEKVLLAIDPEKDVDGFHPMNMGRLWSGNPLMIPSTPAGIMEMFREYDVELSGKRAVVIGRSNIVGKPMAQLLMMADATVTIAHSKTENLRELTKEADVLVVAIGRDRMIKAEDVKEGAVVIDVGMNRDEDGKLHGDVDFDEVKDVASLITPVPGGVGPMTITMLMEQTVRAASRKMNENK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Legionella pneumophila (strain Paris)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.624 kDa

Sequence

MPASLIDGREISALRRNELKQRVQHHVGLGQRPPGLAVVLIGNDPASVIYVSNKRKACEEVGITSHSYDLPAETTQEKLIQLINELNQSDKIDGILIQLPLPKHINERTIIEHIKPEKDVDGFHPYNLGRLAQRNPFLRPCTPLGIMNLLHHYELNVKRKHAVVIGASNIVGRPMSLELLLAGATVTICHKFTQQLQKFVEIADFLIVATGKMDVIATDWLREHQVVIDVGMHRLPDGSIRGDIDFKKAVEKVAWITPVPGGVGPMTIVTLLENTMMSAARLRE

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Legionella pneumophila (strain Corby)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.699 kDa

Sequence

MPASLIDGREISALRRTELKQRVQYHVEQGQRAPGLAVVLIGNDPASVIYVSNKRKACEEVGITSHSYDLPAETTQEKLIELINELNQSDKIDGILIQLPLPKHINERTIIEHIKPEKDVDGFHPYNLGRLAQRNPFLRPCTPLGIMNLLHHYELNVKRKHAVVIGASNIVGRPMSLELLLAGATVTICHKFTQQLQKFVEIADFLIVATGKMDVIATDWLREHQVVIDVGMHRLPDGSIRGDIDFKKAVEKVAWITPVPGGVGPMTIVTLLENTMMSAARLRE

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.68 kDa

Sequence

MPASLIDGREISALRRAELKQRVLYHVEQGQRAPGLAVVLIGNDPASVIYVSNKRKACEEVGITSHSYDLPAETTQEKLIELINELNQSDKIDGILIQLPLPKHINERTIIEYIKPEKDVDGFHPYNLGRLAQRNPFLRPCTPLGIMNLLHHYELNVKRKHAVVIGASNIVGRPMSLELLLAGATVTICHKFTQQLQKFVEIADFLIVATGKMDVIATDWLREHQVVIDVGMHRLPDGSIRGDIDFKKAVEKVAWITPVPGGVGPMTIVTLLENTMMSAARLRE

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Legionella pneumophila (strain Lens)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.699 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Bordetella avium (strain 197N)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.676 kDa

Sequence

MTARIIDGVALSQRIREEVAERAAALTAQGVRPGLAVVLVGEDPASQVYVRNKVAACEKAGLHSVKEQYPADLSEADLLARIDALNRDPSIHGILVQLPLPAHLDSHKVIEAIAPEKDVDGFHISNAGLLMTGQPLFRPCTPYGVMKMLESEGVTLRGAEAVVVGASNIVGKPMAMLLLAAGATVTICNSKTRDLAAQTRRADVLVVATGRPRMITGDMIKPGAVVIDVGINRGDDGKLCGDVDFASAQQVAGAITPVPGGVGPMTIAMLMVNTLQAAERTLTP

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Pasteurella multocida (strain Pm70)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.538 kDa

Sequence

MTAQVISGTELSKTIKSQVAQKIETYTQQGKRSPGLAVILVGADPASQVYVGSKRKSCAEIGIQSKSYDLPETTQESELLALIDELNADTTVDGILVQLPLPKHIDSTKVIERITPEKDVDGFHPYNVGRLCQRIPTLRACTPYGVMKLLETTGIDLHGKHAVIVGASNIVGRPMALELLLAGCTVTVTHRFTKDLAHHVRQADILVVAVGKPKFIPGDWIKAGAIVIDVGINRQEGKLVGDVEYDVALEKAGYITPVPGGVGPMTVAMLMFNTLSAYEMKIAS

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Pelotomaculum thermopropionicum (strain DSM 13744 / JCM 10971 / SI)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.129 kDa

Sequence

MALIIDGRKVAAAIREEVKSEVDRLKERGIVPRLAVILVGEDPASVLYSRSIEKACTRAGVEYELFALPAGIPEDDVVALLSRLNEDGSVHGIMVELPLPKQMNRQKVLEAVSPVKDVDGVHPVNRGYIMSNSEGLFPTTPMSCIEIMLRNGIEIKGKHAVLVGRGESVGKPLVYMMLNQNATVTVCHTFTNDLAYHTRQADILVVAVGKAGMITGDMVKPGAVVVDAGINEAKDGGICGDVDFDSVARVAGAISPVPGGVGSLTTTLILKNTLKAIRLQGGKV

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Polynucleobacter asymbioticus (strain DSM 18221 / CIP 109841 / QLW-P1DMWA-1)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.834 kDa

Sequence

MPAQLLDGNALSKKLRAEIAARAAIVTAKGVRPGLAVIVVGDNPASQVYVRNKVKACEDVGFHSVLEPYPAELGEEELLARIATLNADPAIHGILVQLPLPEHIAAERVLEAIAPEKDVDGFHVSNAGALMVGKPEFIPCTPYGCMKLLESIEYPIRGARAVIVGASNIVGKPMAMLLLQAGATVTICNSKTRDLAHHTKDADILVVATGKPKMVSGDMIKNGAVVIDVGINRLPDGKLCGDVDFDAAKYVAGWITPVPGGVGPMTITMLLMNTLEAAEKASKP

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Polynucleobacter necessarius subsp. necessarius (strain STIR1)

Length

284 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.034 kDa

Sequence

MPAQLLDGNALSKKLRTEIAARSAIVTAKGTRPGLAVIVVGDNPASQVYVRNKVKACEDVGFHSVLERYTAELGEEELLARIATLNADPAIHGILVQLPLPEHIASERVLEAIAPEKDVDGFHVANAGALMVGQSEFKPCTPYGCMKILESIEYPIRSARAVIVGASNIVGKPMAMLLLQAGATVTICNSKTRDLAHHTKDADILVVATGKPKMISGDMVKNGAVVIDVGINRLPDGKLCGDVDFDTAKYVAGWITPVPGGVGPMTITMLLMNTLEAAEKAAKH

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Halothermothrix orenii (strain H 168 / OCM 544 / DSM 9562)

Length

283 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.801 kDa

Sequence

MGKIIDGKKIASEIRNELKEEVKKFTEEGRPPGLSVVLVGDDPASRTYVRMKEKVAKEIGIYSKVDYLSRQTTQDELLDIVDKLNNDEKIDGILVQLPLPDHIDEKAVIEAISPFKDVDGFHPINTGKLFSGMTGQRFEACTPLGIIELLDREGIEIDGKKAVVVGRSNIVGKPVAHLLLERHATVTVCHSHTADLGIETRQADILVVAAGRPKLVKGEMVKEGAAVIDVGTNRVDGHLVGDVDFEAARQRAGYITPVPGGVGPMTIAMLMKNTVKARKYHGV

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Hamiltonella defensa subsp. Acyrthosiphon pisum (strain 5AT)

Length

283 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.643 kDa

Sequence

MSAKIMDGKSIAQQIKNEVAHGVQKRLKQGKRAPGLAVILIGENSASQIYVANKRKACEEVGFVSHCYPLPETTSKAELVSLIKQLNQDPEIDGILVQLPLPERFDSANMLEQIRPDKDVDGFHPYNIGSLCQRIPKLRPCTPLGIMTLLARYDLDPCGLNALVVGASNIVGRPMSLELLLAGCTTTVAHRFTQHLQQHVENADLLVVAVGKPSFIPGTWIKPGAIVIDVGINRLQNGRVVGDVEFDMAATRAAWITPVPGGVGPMTVASLLQNTLKACMERT

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Wigglesworthia glossinidia brevipalpis

Length

283 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.363 kDa

Sequence

MIAKVINGKNIAKKIISKINLKIKKYSKLGMRPASLAMINVGNNPASKIYISNKEKICKKIGLISYLYNFSKNISEIDLINLIIKLNKNNLIDGILVQLPLPKEINKLNVLEKIIPKKDVDGFHPYNIGRLCQRKPTIVPCTPKGIIRLLKYYKINLLGLNAVVVGASNIVGRPMSLELLLEGCTVTITHRFTINLKKYIENAELLIVAIGKAEFIPGSWIKPGAIVIDVGINRLKSGKIVGDVNYEDAIEKASYITPVPGGIGPMTIAMLIENTMQIYINNY

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Anoxybacillus flavithermus (strain DSM 21510 / WK1)

Length

283 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.127 kDa

Sequence

MAAQIINGFELAKEKRAQLAKEVEQLKREGIEPALAVILVGDHPASQSYVKAKQKACEEIGIRSILLTFPNDISESFLLEQIARLNKDRSIHGILVQLPLPSQINELHVIEAIAPEKDVDGFHPLNVGRMMIGQRAFLPCTPYGILYMVQSLQVDIIGKHVVVVGRSHIVGKPVGQLFLREHATVTYCHSRTNDLEAITRQADILIVAVGKPKLITSSYVKEGAIVIDVGVNRLENGKLCGDVDFDDVKQVASYITPVPKGVGPMTITMLLHNTVQAAREQHK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Coxiella burnetii (strain CbuK_Q154)

Length

283 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.834 kDa

Sequence

MIARILDGRTCAEKVKARVKENIRLLQEKGLPSPGLAVILVGNDPASATYVAHKERACQAVGIRSTVYRMPNTITESELASKIDECNRDSNTHGILLQLPLPAHIDPANLLERIRPDKDVDGFHPYNLGRLVQRRPALRPCTPYGVMTLLTETHENLEGKHAVIIGASNIVGRPMALELLLAKCTVTVCHRFTRDLAEHVKSAELLIVAIGKPGIIQSEWIKPGAIVIDVGFSRLSPNKIAGDIDFETAKERASWITPVPGGVGPMTVATLLENTLQAAQTFL

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Coxiella burnetii (strain CbuG_Q212)

Length

283 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.81 kDa

Sequence

MIARILDGRTCAEKVKARVKENIRLLQEKGLPSPGLAVILVGNDPASATYVAHKERACQAVGIRSTVYRMPNTITESELASKIDECNRDSNTHGILLQLPLPAHIDSANLLERIRPDKDVDGFHPYNLGRLVQRRPALRPCTPYGVMTLLTETHENLEGKHAVIVGASNIVGRPMALELLLAKCTVTVCHRFTRDLAEHVKSAELLIVAIGKPGIIQSEWIKPGAIVIDVGFSRLSPNKIAGDIDFETAKERASWITPVPGGVGPMTVATLLENTLQAAQTFL

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Coxiella burnetii (strain Dugway 5J108-111)

Length

283 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.82 kDa

Sequence

MIARILDGRTCAEKVKARVKENIRLLQEKGLPSPGLAVILVGNDPASATYVAHKERACQAVGIRSTVYRMPNTITESELASKIDECNRDSNTHGILLQLPLPAHIDPANLLERIRPDKDVDGFHPYNLGRLVQRRPALRPCTPYGVMTLLTETHENLEGKHAVIVGASNIVGRPMALELLLAKCTVTVCHRFTRDLAEHVKSAELLIVAIGKPGIIQSEWIKPGAIVIDVGFSRLSPNKIAGDIDFETAKERASWITPVPGGVGPMTVATLLENTLQAAQTFL

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Coxiella burnetii (strain RSA 331 / Henzerling II)

Length

283 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.82 kDa

Sequence

MIARILDGRTCAEKVKARVKENIRLLQEKGLPSPGLAVILVGNDPASATYVAHKERACQAVGIRSTVYRMPNTITESELASKIDECNRDSNTHGILLQLPLPAHIDPANLLERIRPDKDVDGFHPYNLGRLVQRRPALRPCTPYGVMTLLTETHENLEGKHAVIVGASNIVGRPMALELLLAKCTVTVCHRFTRDLAEHVKSAELLIVAIGKPGIIQSEWIKPGAIVIDVGFSRLSPNKIAGDIDFETAKERASWITPVPGGVGPMTVATLLENTLQAAQTFL

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Coxiella burnetii (strain RSA 493 / Nine Mile phase I)

Length

283 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.82 kDa

Sequence

MIARILDGRTCAEKVKARVKENIRLLQEKGLPSPGLAVILVGNDPASATYVAHKERACQAVGIRSTVYRMPNTITESELASKIDECNRDSNTHGILLQLPLPAHIDPANLLERIRPDKDVDGFHPYNLGRLVQRRPALRPCTPYGVMTLLTETHENLEGKHAVIVGASNIVGRPMALELLLAKCTVTVCHRFTRDLAEHVKSAELLIVAIGKPGIIQSEWIKPGAIVIDVGFSRLSPNKIAGDIDFETAKERASWITPVPGGVGPMTVATLLENTLQAAQTFL

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337)

Length

283 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.863 kDa

Sequence

MPAQLIDGNALAKQIRSEAALRAARLTERGHRPGLAVILVGEDPASQVYVRNKVKACQDNGFHSSLDRYPADLSEAELLARIEALNQDPNIHGILVQLPLPKHIDSHKVLEAIAPEKDVDGFHVANAGALMTGAPLFRPCTPYGCMKMLESVQFPLRGARAVVVGASNIVGKPMAMLLLQAGATVTICNSKTRDIGAHTRDADVVVAAVGKRNLITADMVKPGAVVIDVGMNRDDNGKLCGDVDFAGVREVAGYITPVPGGVGPMTITMLLVNTLEAAERAAG

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Cupriavidus necator (strain JMP 134 / LMG 1197)

Length

283 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.8 kDa

Sequence

MSAQLIDGNALAKQIRSEAAVRAARLTERGHQPGLAVVLVGEDPASQVYVRNKVKACEDNGFHSSLDRYPADLSEAELLARIDALNNDPKIHGILVQLPLPKHIDSHKVLEAIAPEKDVDGFHVANAGALMTGAPLFRPCTPYGCMKMLESISYPLRGARAVVVGASNIVGKPMAMLLLQAGATVTICNSKTRDIGAHTRDADVIVAAVGKRNLITADMVKPGAVVIDVGMNRDDNGKLCGDVDFAGVREVAGYITPVPGGVGPMTITMLLINTLEAAERAAG

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Cupriavidus taiwanensis (strain DSM 17343 / BCRC 17206 / CIP 107171 / LMG 19424 / R1)

Length

283 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.99 kDa

Sequence

MPAQLIDGNALAKQIRSEAAQRAARLTERGHQPGLAVVLVGEDPASQVYVRNKVKACEDNGFHSSLDRYPADLSEADLLARIDELNRDPRIHGILVQLPLPKHIDSHKVLEAIAPEKDVDGFHVANAGALMTGAPLFRPCTPYGCMKMLESIQYPLRGARAVVVGASNIVGKPMAMLLLQGGATVTICNSKTRDIGAHTRDADVVVAAVGKRNLITADMVKPGAVVIDVGMNRDDHGKLCGDVDFAGVREVAGYITPVPGGVGPMTITMLLINTLEAAERAAG

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Mycoplasma gallisepticum (strain R(low / passage 15 / clone 2))

Length

283 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

32.338 kDa

Sequence

MFIKLDGTKLSQKLKEDLAKKVNNQKIKILIIISDPSEASRIYVRNKINYCDSLGIQTEVYDLSKIDDTNQFIVEMNQKISLSNPNGVLVQLPIKERLDTNKIIENIPIRLDVDAFLYHRFDQDQKEKVIPCVLNAVLELFKEYQLSFLDKKILLIGNGITSNQPIVNYLNEHQIKFDLITKENSQLLEEKTKVADLVISAVGKAKFLANYQFKRGVIFIDIGIDKYFDPEQSKYLICGDFDYDKLKEIASYGTPTPGGIGPLTIYSLVKNLINLSEIQKVNK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)

Length

283 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.693 kDa

Sequence

MGAISLDGKTTRDEIFVDLKERVAALTAAGRTPGLGTVLVGDDPGSQAYVRGKHADCAKVGINSIRRDLPADITTEQLNETIDELNANPDCTGYIVQLPLPKHLDENAALERIDPAKDADGLHPTNLGRLVLGKQAALPCTPRGIVHLLRRFDVPIAGAHVVVIGRGVTVGRPMGLLLTRRSENATVTLCHTGTRDLPALTRQADIIIAAVGVPHMVTADMVKPGAAVVDVGVSRVDGKLTGDVAPDVWEVAGHVSPNPGGVGPLTRAFLLTNVVEAEESKLA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Anoxybacillus flavithermus (strain DSM 21510 / WK1)

Length

283 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.127 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Coxiella burnetii (strain CbuK_Q154)

Length

283 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.834 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Coxiella burnetii (strain CbuG_Q212)

Length

283 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.81 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Coxiella burnetii (strain Dugway 5J108-111)

Length

283 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.82 kDa

Sequence

MIARILDGRTCAEKVKARVKENIRLLQEKGLPSPGLAVILVGNDPASATYVAHKERACQAVGIRSTVYRMPNTITESELASKIDECNRDSNTHGILLQLPLPAHIDPANLLERIRPDKDVDGFHPYNLGRLVQRRPALRPCTPYGVMTLLTETHENLEGKHAVIVGASNIVGRPMALELLLAKCTVTVCHRFTRDLAEHVKSAELLIVAIGKPGIIQSEWIKPGAIVIDVGFSRLSPNKIAGDIDFETAKERASWITPVPGGVGPMTVATLLENTLQAAQTFL

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Coxiella burnetii (strain RSA 331 / Henzerling II)

Length

283 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.82 kDa

Sequence

MIARILDGRTCAEKVKARVKENIRLLQEKGLPSPGLAVILVGNDPASATYVAHKERACQAVGIRSTVYRMPNTITESELASKIDECNRDSNTHGILLQLPLPAHIDPANLLERIRPDKDVDGFHPYNLGRLVQRRPALRPCTPYGVMTLLTETHENLEGKHAVIVGASNIVGRPMALELLLAKCTVTVCHRFTRDLAEHVKSAELLIVAIGKPGIIQSEWIKPGAIVIDVGFSRLSPNKIAGDIDFETAKERASWITPVPGGVGPMTVATLLENTLQAAQTFL

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Coxiella burnetii (strain RSA 493 / Nine Mile phase I)

Length

283 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.82 kDa

Sequence

MIARILDGRTCAEKVKARVKENIRLLQEKGLPSPGLAVILVGNDPASATYVAHKERACQAVGIRSTVYRMPNTITESELASKIDECNRDSNTHGILLQLPLPAHIDPANLLERIRPDKDVDGFHPYNLGRLVQRRPALRPCTPYGVMTLLTETHENLEGKHAVIVGASNIVGRPMALELLLAKCTVTVCHRFTRDLAEHVKSAELLIVAIGKPGIIQSEWIKPGAIVIDVGFSRLSPNKIAGDIDFETAKERASWITPVPGGVGPMTVATLLENTLQAAQTFL

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337)

Length

283 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.863 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Cupriavidus necator (strain JMP 134 / LMG 1197)

Length

283 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.8 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Cupriavidus taiwanensis (strain DSM 17343 / BCRC 17206 / CIP 107171 / LMG 19424 / R1)

Length

283 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.99 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Mycoplasma gallisepticum (strain R(low / passage 15 / clone 2))

Length

283 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

32.338 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)

Length

283 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.693 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Dictyoglomus thermophilum (strain ATCC 35947 / DSM 3960 / H-6-12)

Length

283 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.535 kDa

Sequence

MGVILEGKPVAEKLEKEIKEKIEIYKTKGIIPNLCIVKVGENEEAEAYAKSIERFFSRIGINVERKNFAENVSLLEFQKALKELEKNNKVHGILILRPLSEELERQKAFRFLSPDKDVEGITYENLGKLFVGEKCFHPCTPQAVIELLDFYKISVEGKDVVVVGRSISVGKPLSILLLNRNATVTICHSKTKNLEELTRRAEVLVAAVGRPHFIGKDMVKEGQVVIDIGTNVVEGKLVGDVNFEEVKDKVGYITPVPGGIGIITTRVLAMNLLKAVEKNEARN

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131)

Length

283 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.601 kDa

Sequence

MLMDGKELARDIKVKIKAEIDNIKKIHNINPMVATILVGDDPASQVYLNSQVKSYQDLGIGVQKYFFSEEISEAYLLNLIDKLNKDTEVDGIMINLPLPPQINATKVLNSIKLIKDVDGFKAENLGLLFQNNEGFTSPSTPAGIMALIEKYNIDLEGKDVVVVGSSNIVGKPIAALILNSRGTVTICNIYTKNLAEKTKNADILISAVGKAKLITEDMVKEGAVVIDVGINRVNGKLEGDVDFENVQKKASHITPVPGGVGALTVAMLLSNILKSFKANRGII

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Variovorax paradoxus (strain S110)

Length

283 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.691 kDa

Sequence

MTAQLIDGNALAKTIRAEVAGRTAALKAKGVEPALSIILVGSDPASQVYTKHKVNDSTETGLAATLETYPADMSEAALLDRIRALNDDPKVHGILVQLPLPRHMDSQKVIETISPAKDVDGFHVASAGALMTGAPGFWPCTPYGCMKMLESIGYDLRGKHAVVIGRSNIVGKPMAMMLLARSATVTICHSATQDLAAFTRQADVIVAAVGKRNILTAGMVKPGAVVIDVGMNRKEDGKLAGDVDFDGVKEVAGWITPVPGGVGPMTRAMLLVNTLEAAERAAK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Nocardia farcinica (strain IFM 10152)

Length

283 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

28.552 kDa

Sequence

MDTVSLTGKELAAALNADTKQRAEALTAGGVAARLALIVANDDPASAWYVNSLRKAAERLGIACERIDLGADATADGIRAELRERSADPAFDAIMLQTPLPASVALDDVSSAIAADKDVDGVSPLSLGLLAAGLAGFVPATAQAVVELLKHHEIALSGRHVAVVGRSNVVGKPLAQLLLAENATVTVCHSRTTDLAAITSTADVVVAAVGRAGLVTGDHVRAGAVVVDVGTNEAEDGGIVGDVDAESVRGKAAGLSPVPGGVGPVTTALLMRHVVEAAERHRG

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)

Length

283 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.299 kDa

Sequence

MILDGKAVSEKRLELLKEEIEESGLYPRLATVIVGEDPASQMYVRMKHRACERVGIGSIGIELPADASTEQVLEAVARLNNDPDINGILVQLPLPGGVDTTRVIDAVAPEKDVDGFHPCSLGRLFSGTPVFAPCTPQGIMTILDEYRIPIRGKRAVVVGRSIDVGRPMAALLLNADATVTICHSKTENLEDEMRRADILVSAIGKAKFVGPEMVKEGATVIDVGINQDEQGKLCGDVDFDAVKDRAGAITPVPGGVGPMTIATLMENTFRAAKLRTCGNNTVR

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Methylibium petroleiphilum (strain ATCC BAA-1232 / LMG 22953 / PM1)

Length

283 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.874 kDa

Sequence

MSARAIDGNALSRHLRHEVAQRAATLREHGITPGLAVILVGENPASQVYVRNKVKACHDSGLHSVLEHYPAAMTEAELLARVQALNADPAIHGILVQLPLPPHIDAHRVIETIAPHKDVDGFHVASAGALMVGQPGFKPCTPYGCMKMLESIGYDPKGKHAVVIGRSNIVGKPMAMLLLQANATVTVCHSATPDLALHTRQADIVVAAVGKRKVLTADMVKPGAVVIDVGMNRDDHGKLCGDVDYAGVAKVAGWITPVPGGVGPMTITMLLMNTLESAERLVG

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Bacillus pumilus (strain SAFR-032)

Length

283 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.527 kDa

Sequence

MTATIIDGKETAKEKREQLAKEVEELKQKGVTPGLAVILIGDDPASLSYVRGKKKAAEAMGMHFQLDHLDASLTEEELLQLIDQYNANDQFHGILVQLPLPKHISEKAVIERISPEKDVDGFHPLNIGKMLLGEDTFLPCTPAGIVELLNKTGVNLSGKEVVVVGRSNIVGKPVGQLLLNENATVTYCHSRTANISEHTLKADILVVAVGRANFIKADQIKEGAIVIDVGVNRLDTGKLVGDVDFEEAKEKASYITPVPGGVGPMTITMLAHNTVKSAKRTLA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Bacillus subtilis (strain 168)

Length

283 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.685 kDa

Sequence

MTATIIDGKETAREKREQLAKEVEELKKQGVTPGLAVILIGDDPASHSYVRGKKKAAETMGMNFKLDQFDSSLTEAELLSIIDQYNQDPEFHGILVQLPLPDHISEKAVIERISPDKDVDGFHPLNVGKMLLGEDTFLPCTPHGIVELLKKTNIDLSGKEVVVVGRSNIVGKPVGQLLLNENATVTYCHSRTENITEHTKKADILVVAVGRANFISADQIKEGAVVIDVGVNRLENGKLCGDVEFEGAKEKASFITPVPGGVGPMTITMLAHNTVKSAKRTLS

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Herminiimonas arsenicoxydans

Length

283 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.658 kDa

Sequence

MSAHIIDGNLLSQQLRQDVATRAAALSAKGKQPGLAVILVGADPASQVYVRNKVKACEDNGLFSLLEKYEADMTEAALLARIAALNNDPAIHGILVQMPLPKHIDPTKVIEAISPRKDVDGYSVLSAGELLTGLPGFRPCTPYGCMKLIESTGTKIAGKHAVVIGRSNTVGKPMALLLLQANATVTICHSGTADLGYHTRQADIVVAATGRRNTLTADMIKPGAIVIDVGINRDDNGKLCGDVDFAAAKEVAGHISPVPGGVGPMTITMLLVNTIEAAERETN

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Janthinobacterium sp. (strain Marseille)

Length

283 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.822 kDa

Sequence

MTAQIIDGNLLSQQLRKDVAVRAAALTAKGKQPGLAVILVGADPASQVYVRNKVKACEDNGLYSLLEKYDADMTEAALLARIAALNADPKIHGILVQMPLPKHIDSNKVIEAISPRKDVDGYSVLSAGELLTGLPGFRPCTPYGCMKLIESTGTKLAGKHAVVIGRSNTVGKPMALLLLQANATVTICHSGTADLAYHTRQADVVVAATGRRNTLTAEMIKPGAIVIDVGINRDDNGKLCGDVDFANAKEVASYITPVPGGVGPMTITMLLVNTIEAAERETN

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM)

Length

283 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.085 kDa

Sequence

MGKILDGKFVANLLGEKLKEKVKDLKEEGITPHFCVINIGDDPASKIYVRTKKRRAEKMGIIQDIYQLPADTKQEVALNLIDKLNEDPDINGVMVQLPAPEQIDADELLERIDPNKDVDGLTPSNIGRIWMENHFIEPATAEGIIALLKYYKILLKGKNVVVIGRSNIVGKPVAALMLEQNATVTIAHSETENLAELTRNADIIVSATGQAFLVTEDMVKDGVVVVDVGMNHVNGKLVGDVDFENVKKKASYITPVPGGVGPLTVQFLMEAVVKLTRRQNGRE

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Lactobacillus casei (strain BL23)

Length

283 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.597 kDa

Sequence

MATRLDGRAVSKKILADLKQTIAELAQHDVTPTLAVVLVGSNPASEVYVRNKQRRAEDIGVRSLMFRMPEATTQADLLAKVAELNHDPDIDAILVQLPLPAGLDEQAVIDAIDPDKDVDGFSPVSVGRLWANEPTVVASTPYGIMALLDAYDIDVAGKRVVIIGRSNIVGRPLAGLMVNHDATVTIAHSKTRDLKQLAKEADILVVAVGVPHFIGADAVKPGAVVIDVGISRGADGKLLGDVDEAAVAPIASAITPVPGGVGPMTIASLMAQTVTLAKRRANG

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC 11842 / DSM 20081 / JCM 1002 / NBRC 13953 / NCIMB 11778)

Length

283 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.635 kDa

Sequence

MGEILDGKKLAWELGEKLGSEVDSLKEHGVSPKLCVINIGDDPASKVYVASKKRKAEKLGIKQVVYQLPADESEEDVLKLIDSLNADPEVSSLMVQLPVPPQINADRVIERIDPEKDVDCLTPANIGRLWQGKHFVEPATAAGIIALLDHYQIDLTGKNAVIVGRSNIVGKPLAALMLERNASVSILHSRSRNLADLTKQADILVCAVGKAEMIKADMVKEGAVVIDVGINRVDGHLVGDVDFAPVKEKASWITPVPGGVGPLTVEFLMEEVIKLTRRQHGLD

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC BAA-365)

Length

283 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.604 kDa

Sequence

MGEILDGKKLARELGEKLGSEVDSLKEHGVSPKLCVINIGDDPASKVYVASKKRKAEKLGIKQVVYQLPADESEEDVLKLIDSLNADPEVSSLMVQLPVPPQINADRVIERIDPEKDVDCLTPANIGRLWQGKHFVEPATAAGIIALLDHYQIDLTGKNAVIVGRSNIVGKPLAALMLERNASVSILHSRSRNLADLTKQADILVCAVGKAEMIKADMVKEGAVVIDVGINRVDGHLVGDVDFAPVKEKASWITPVPGGVGPLTVEFLMEEVIKLTRRQHGLD

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Acidovorax citrulli (strain AAC00-1)

Length

283 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.882 kDa

Sequence

MTAQLIDGNALSRQLRADVARRAALLKERGTTPGLAVVLVGDNPASQVYVRNKVKACEESGLHSVLEKYDAAMSEAELLARVDALNNDPSIHGILVQLPLPAHIDAQKVIEAISPAKDVDGFHIASAGALMTGMPGFWPCTPYGCMKMLEHIGYDLRGKHAVVIGRSNIVGKPMALMLLAKDATVTVCHSRTADLKAQTLQADVIVAAVGRRNVLTADMVKPGAVVIDVGMNRNDEGRLCGDVDFDGVREVAGHITPVPGGVGPMTITMLLVNTLEAAERAAG

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Campylobacter concisus (strain 13826)

Length

283 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.12 kDa

Sequence

MKILDGKAVSLKVKESVKVRADELKKFGVEPTLAVVLVGEDKASQTYVRAKEKACNEYGIKSVAHRLSENTTQNELLALINVLNLDDSIHGILVQLPLPKHIDTNVVLAAIDPRKDVDGFHAVNVGKLVSGLDGFVPCTPLGVMEILKEYGIEVAGLNAVVIGRSNIVGKPMANLLLNASATVTVTHSKTKNLKEICKNADLIVAAIGKPFFLKADMVKDGAVVVDVGINRLDDGRLVGDVDFDEVAPKCSYITPVPGGVGPMTIAMLLNNTILAAQAKIAKN

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Campylobacter fetus subsp. fetus (strain 82-40)

Length

283 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.017 kDa

Sequence

MQIIDGKSVSAKVKEYVKNEAISLKKSGITPTLAVILVGEDKASQTYVASKEKACLACEMGSVMHRLSKETSQSELLALIEVLNLDDSIDGILVQLPLPKHIDTNRVLEAIDPTKDVDGFHAVNVGKLSSGLDGFVPCTPLGIMELLKEYDVNLQGIDAVVIGRSNIVGKPMASLLLNAGATISIAHSKTKNLPEITRRAKLVVVAVGRPNFLNADMVSDGAIVIDVGINRLDSGKLVGDVDFDSVAPKCSLITPVPGGVGPMTIAMLLSNTLKSAKNRKRNV

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Lactobacillus paracasei (strain ATCC 334 / BCRC 17002 / CIP 107868 / KCTC 3260 / NRRL B-441)

Length

283 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.582 kDa

Sequence

MATRLDGRAVSKKILADLKQTIAQLAQHDVTPTLAVVLVGSNPASEVYVRNKQRRAEDIGVRSLMFRMPEATTQADLLAKVAELNHDPDIDAILVQLPLPAGLDEQAVIDAIDPDKDVDGFSPVSVGRLWANEPTVVASTPYGIMALLDAYDIDVAGKRVVIIGRSNIVGRPLAGLMVNHDATVTIAHSKTRDLKQLAKEADILVVAVGVPHFIGADAVKPGAVVIDVGISRGADGKVLGDVDEAAVAPIASAITPVPGGVGPMTIASLMAQTVTLAKRRANG

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Lactobacillus sakei subsp. sakei (strain 23K)

Length

283 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.223 kDa

Sequence

MELLDGRALANELTHAQQTAVETLKEQGVTPKLVVIMVGDDPASAIYTQSKQKRATKIGMASELKRLSAETTEAELLALVKTLNDDRTVDGILVQLPLPKQINEDHVIQAIDAKKDVDGFSPVNIGQLWLNQPGLVACTPNGIMRLLAAHKIDVAGKNVVIVGRSNIVGRPLAALMLNANATVTIAHSRTANLKALTKTADILVAAIGKPHFFGIDAVKEGAVVIDVGINRLEDGSVTGDVDFEALQTHVSAMTPVPRGVGPMTITMLMEQTIEIAKERVKRG

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Laribacter hongkongensis (strain HLHK9)

Length

283 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.254 kDa

Sequence

MTAQLIDGKTISAALLDRVAAGVKARTEAGKRAPALAVILVGNNPASEVYVRNKKKGCEKAGIQSLAYDLPESTSEADLLALVDELNARSDVDGILVQLPLPRHINPETVIERINPKKDVDGFHPYNMGRLAVKMPLLRPCTPRGVMIMLEHAGISVEGKHAVVIGQSNIVGRPMALELLMERATVTICHSRTRDLPEEVKRADIIVAAVGIPRFVKGDWVKPGAVVIDVGINRLEDGKLCGDVDFDAAKEHASWITPVPGGVGLMTVATLLANTLDAANLHA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Rickettsia bellii (strain OSU 85-389)

Length

283 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.284 kDa

Sequence

MNNVIDGKALANEILSELKHEVQRLKDKTGESPKLAIVLVGDNPASIIYVKNKIKHANKIGIDTLLLNLPITIKTEDLIAKISELNLDQNVSGIIVQLPLPDSIDKNKILSAISPSKDVDGFHPLNVGYLHSGIDNGFVPCTSLGCLEVIKKHEPNLSGKNAIIVGRSNIVGKPLSALLLKENCSVTICHSKSQNLSSITSKADIVVAAIGSPLKLTSGYFKPDAIVIDVGINRIGGNKIVGDVDFENVKSKVKYITPVPGGIGPMTIAFLLKNTVQAFKIYS

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Rickettsia bellii (strain RML369-C)

Length

283 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.267 kDa

Sequence

MNNVIDGKALANEILSELKHEVQRLKDKTGESPKLAIVLVGDNPASIIYVKNKIKHANKIGIDTLLLNLPITIKTEDLIAKISELNLDQNVSGIIVQLPLPNSIDKNKILSAISPSKDVDGFHPLNVGYLHSGIDNGFVPCTALGCLEVIKKHEPNLSGKNAIIVGRSNIVGKPLSALLLKENCSVTICHSKSQNLSSITSKADIVVAAIGSPLKLTSGYFKPDAIVIDVGINRIGGNKIVGDVDFENVKSKVKYITPVPGGIGPMTIAFLLKNTVQAFKIYS

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / FZB42)

Length

283 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.62 kDa

Sequence

MTATIIDGKETAKEKREQLAKEVEELKAQGVVPGLAVILIGDDPASVSYVTGKKKAAETMGMKFKLDRFDSSLTEAELLTVIDQYNQNPEFHGILVQLPLPDHISEKAVIERISPDKDVDGFHPLNVGKMLLGEDTFLPCTPHGIVELLKKTNVDLSGKEVVVVGRSNIVGKPVGQLLLNENATVTYCHSRTKNMSEHTKKADILVVAVGKANFIKADQIKEGAIVIDVGVNRLESGKLCGDVQFDEAKEKASFITPVPGGVGPMTITMLAHNTVKSARRTLS

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50)

Length

283 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.489 kDa

Sequence

MTARIIDGAALSQRIREEVAQRVQALTAKGVRPGLAVVLVGDDPASQVYVRNKVAACEKAGLHSVKEQYPADLTEAQLLERIDALNRDPSIHGILVQLPLPRHMDAHKVIEAIAAEKDVDGFHISNAGLLMTGQPLFRPCTPYGVMKMLESEGVALRGAEAVIVGASNIVGKPMAMLLLQAGATITICNSKTRDLGAQTRRADVLVVATGKPGMIDGSMIKPGAVVIDVGINRGADGKLCGDVDMASAREVAGAISPVPGGVGPMTIAMLLVNTVEAAERAAA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w)

Length

283 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.039 kDa

Sequence

MGQIIDGKTLAAEIDKQTMTEVQKLKNQGVEPHLVVVLVGENPASQIYVRNKEKRANKLGIKSTLVTMNADISENELLLKIQELNQTEDVNAILVQMPLPKHIDAFKVTMAIDPRKDVDGFHPVNVGKLFEGKTQHTPIACTPQGIMEMFQKYHIDIQGKRAVVVGRSSIVGKPMAALLLNANATVTLAHSYTKNLAALTKEADILVVATGIAHFIKEDQVKEGAVVIDVGMDRDENGKLTGDVDFENVEKHVSYITPVPKGVGPMTISMLMKQTVNLTKWSI

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Pelobacter propionicus (strain DSM 2379 / NBRC 103807 / OttBd1)

Length

283 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.071 kDa

Sequence

MAHIIDGKAIAAKIRSEIASGVRELQGKGVTPGLAVVLVGDDQASRVYVSMKEKACNDAGIFSVEHKLAAETSEAELLALVELLNNDPKIHGILVQLPLPSQIDTDKVLEAISPFKDVDGFHPYNVGRLSVGKPVFQPCTPYGVMVMLREAGVELKGKEVVVVGRSNIVGKPVAMMCLAEHATVTLCHSRTRDLPDVVRRADVVIAAVGRPEMIKGDWIKEGAVVIDVGINRVGEKKLVGDVEFAGASQRASAITPVPGGVGPMTITMLLQNTLESAKRGMAE

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Thermobifida fusca (strain YX)

Length

283 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.35 kDa

Sequence

MTAQVLDGKATAAAIREELKERVAALRARGVVPGLGTILVGDDPGSHAYVRGKHRDCAEVGIASIRKDLPADATQADVEAAVAELNADPACTGFIVQLPLPRGLDENRVLEKIDPAKDADGLHPSNLGKLVLMEEAPLPCTPRGIVELLNRYGVSLRGAEVVVVGRGVTVGRPLGLLLTRRSENATVTLCHTGTRDLAAHTRRADIVVAAAGVPGLITKDMVSPGAVVLDVGVTRTEKGLVGDVAPDVAEVAGYLSPNPGGVGPMTRAMLLTNVVEAAERSLS

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Haemophilus influenzae (strain 86-028NP)

Length

282 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.46 kDa

Sequence

MAAKIISGTELSKQIKANLADKITHYIEQGKRAPGLAVILVGADPASQIYVGNKRKSCEEVGILSKSYDLPETTTQNELLAIIDQLNADKNIDGILVQLPLPKQINAEAIIERIDPKKDVDGFHPYNVGRLCQRIPTLRACTPYGVMKLLETTGIDLHGKHAVIVGASNIVGRPMSLELLLAGATVTVTHRFTKNLENHVRQADILVVAVGKPNLISGDWIKESAVVIDVGINRVDGKLVGDVEFDKAAEKAAYITPVPGGVGPMTVAMLMSNTLYAYEHNK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Haemophilus influenzae (strain PittEE)

Length

282 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.46 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Haemophilus influenzae (strain PittGG)

Length

282 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.483 kDa

Sequence

MAAKIISGTELSKQIKANLADKITHYIEQGKRVPGLAVILVGADPASQIYVGNKRKSCEEVGILSKSYDLPETTTQNELLAIIDQLNADKNIDGILVQLPLPKQINAEAIIEHIDPKKDVDGFHPYNVGRLCQRIPTLRACTPYGVMKLLETTGIDLHGKHAVIVGASNIVGRPMSLELLLAGATVTVTHRFTKNLENHVRQADILVVAVGKPNLISGDWIKESAVVIDVGINRVDGKLVGDIEFDKAAEKAAYITPVPGGVGPMTVAMLMSNTLYAYEHNK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

Length

282 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.46 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Haemophilus somnus (strain 129Pt)

Length

282 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.616 kDa

Sequence

MPAQIISGTELSKNIKFNVAEKIQHYLQQGKRAPGLAVILVGADPASQVYVGSKRRSCEELGIYSKSYDLPAETTEQELLTLIEQLNQDPQIDGILVQLPLPKKINSTKVIEHISPTKDIDGFHPYNVGRLCQRIPTLRACTPLGIMKLLETTGVDLYGQHAVIVGASNIVGRPMALELLLAGCTVTVTHRFTKDLKSHVHQADILVVAVGKPHIIPGEWIKEGAIVIDVGINRVDGKLVGDVQYDEASKKASFITPVPGGVGPMTVAMLMFNTLLAYESHS

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Anaeromyxobacter dehalogenans (strain 2CP-C)

Length

282 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.392 kDa

Sequence

MNLIDGKQIAAKVKGEVATEVRALAARGVQTGLTVVRVGDDPASAIYVRGKRKDCEEVGITSVEHHLPVTTTQAELLALIARLNADPAVHGILVQLPLPKHVDERAVLDAISPAKDADGFHPFNVGALSIGIAGVPRPCTPAGVMRMLDEARVDPKGKRALVVGRSNIVGKPMAMMLLERHATVTIAHSRTADLAGEVGRADILVAAIGKAELVKGAWVKEGAVVIDVGMNRLADGKLVGDVEFAAAAARASAITPVPGGVGPMTRAMLLVNTVELAKRVAR

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Mycobacterium leprae (strain Br4923)

Length

282 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.835 kDa

Sequence

MGAITLDGKATRDEILIDLKQRVAALTESGRTPGLGTILVGDDPGSHAYVRGKHADCAKVGITSIRRDLPVDITTAVLHDTIEELNANPDCTGYIVQLPLPKYLDENTALERVDPAKDADGLHPTNLGRLVLSTPAPLPCTARGILHLLRRYGVEIAGTHVVIIGRGVTVGRPLGLLLTRRSENATVTLCHTGTRNLAALTKQADIIVAAVGVPHLLTADMVRPGAVVVDVGVSRVETRLVGDVHPDVWEVAGHVSPNPGGVGPLTRVFLLTNVVELAEGRQ

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Mycobacterium leprae (strain TN)

Length

282 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.835 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Mycoplasma penetrans (strain HF-2)

Length

282 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.096 kDa

Sequence

MIVNCIDIANNILDKFKSDLEKLKKKKIIPHMAIVKINDDAASDKYVSIKLKKAAELGVKTTLISEGIKTQDDLIKQIHILNNDDSIDGYIIQLPLPKGFDSNVICEHIDVNKDIDGLSSFAISRNLANSNLFHPKPCTANGIIEILKQSNYSIEGKHAVIINRSMIVGKPLIGLFLENNATVTVCHTKTQNLKEMTKTADIVVVAIGKPDFLTKDMVNPNAFVIDAGISVVDGKVVGDAAKDLQEYVKYITPVPNGVGRLTVAMIFKNLMDLVKEKYNERI

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Anaeromyxobacter dehalogenans (strain 2CP-C)

Length

282 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.392 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Mycobacterium leprae (strain Br4923)

Length

282 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.835 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Mycobacterium leprae (strain TN)

Length

282 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.835 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Mycoplasma penetrans (strain HF-2)

Length

282 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.096 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Streptococcus suis (strain 98HAH33)

Length

282 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.603 kDa

Sequence

MTVIDGKALGVKLQAALAEKTARLKEEKGLVPGLVVILVGENPASQVYVRNKERSALAAGFKSEVVRVPDTISESDLLDLIERYNQDDEWHGILVQLPLPAHISEEKVLLAIDPDKDVDGLHPTNMGKFWSGHPVMIPSTPAGIMEMFKEYQIELEGKSALVIGRSNIVGKPMAQLLLDADATVTIAHSRTKNLPDLARQADIVVVAIGRGHFVTKEFVKLGAVVIDVGMNRDENGKLIGDVKYDEVSEVASYITPVPGGVGPMTITMLMEQTYEACVRSAK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Streptococcus suis (strain 05ZYH33)

Length

282 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.651 kDa

Sequence

MTVIDGKALGVKLQAALAEKTARLKEEKGLVPGLVVILVGENPASQVYVRNKERSALAAGFKSEVVRVPDTISESDLLDLIERYNQDDEWHGILVQLPLPAHISEEKVLLAIDPDKDVDGFHPTNMGKFWSGHPVMIPSTPAGIMEMFKEYQIELEGKSALVIGRSNIVGKPMAQLLLDADATVTIAHSRTKNLPDLARQADILVVAIGRGHFVTKEFVKLGAVVIDVGMNRDENGKLIGDVKYDEVSEVASYITPVPGGVGPMTITMLMEQTYEACVRSAK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Francisella philomiragia subsp. philomiragia (strain ATCC 25017)

Length

282 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.482 kDa

Sequence

MTLIDGKKLSIDLKERLTDQLREYKEQTGIVPKLVAIIVGDDPASKTYVGSKEKACEKVGINSEVITLPEATTEQELLELIDKLNDDSSVHAILVQLPLPTHINKQKVIYAIKPEKDVDGFHPANVGRLQLRDKKCLESCTPKGILTMLKEYGIQTEGAHAVVVGASNVVGKPVSQLLLNAKATVTTCHRFTKDLKSHTTKADILVVAVGKPGFITADMVKDGAVVIDVGINHVDGKIVGDVDFEAVKDKVAAITPVPGGVGPMTITELLYNTFQCAQELNR

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Francisella tularensis subsp. tularensis (strain FSC 198)

Length

282 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.454 kDa

Sequence

MILIDGKSLSKDLKERLATQVQEYKHHTAITPKLVAIIVGNDPASKTYVASKEKACAQVGIDSQVITLPEHTTESELLELIDQLNNDSSVHAILVQLPLPAHINKNNVIYSIKPEKDVDGFHPTNVGRLQLRDKKCLESCTPKGIMTMLREYGIKTEGAYAVVVGASNVVGKPVSQLLLNAKATVTTCHRFTTDLKSHTTKADILIVAVGKPNFITADMVKEGAVVIDVGINHVDGKIVGDVDFAAVKDKVAAITPVPGGVGPMTITELLYNTFQCAQELNR

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Francisella tularensis subsp. holarctica (strain FTNF002-00 / FTA)

Length

282 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.482 kDa

Sequence

MILIDGKSLSKDLKERLATQVQEYKHHTAITPKLVAIIVGNDPASKTYVASKEKACAQVGIDSQVITLPEHTTESELLELIDQLNNDSSVHAILVQLPLPAHINKNNVIYSIKPEKDVDGFHPTNVGRLQLRDKKCLESCTPKGIMTMLREYGIKTEGAYVVVVGASNVVGKPVSQLLLNAKATVTTCHRFTTDLKSHTTKADILIVAVGKPNFITADMVKEGAVVIDVGINHVDGKIVGDVDFAAVKDKVAAITPVPGGVGPMTITELLYNTFQCAQELNR

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Francisella tularensis subsp. holarctica (strain LVS)

Length

282 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.482 kDa

Sequence

MILIDGKSLSKDLKERLATQVQEYKHHTAITPKLVAIIVGNDPASKTYVASKEKACAQVGIDSQVITLPEHTTESELLELIDQLNNDSSVHAILVQLPLPAHINKNNVIYSIKPEKDVDGFHPTNVGRLQLRDKKCLESCTPKGIMTMLREYGIKTEGAYVVVVGASNVVGKPVSQLLLNAKATVTTCHRFTTDLKSHTTKADILIVAVGKPNFITADMVKEGAVVIDVGINHVDGKIVGDVDFAAVKDKVAAITPVPGGVGPMTITELLYNTFQCAQELNR

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Francisella tularensis subsp. mediasiatica (strain FSC147)

Length

282 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.526 kDa

Sequence

MILIDGKSLSKDLKERLVTQVQEYKHHTAITPKLVAIIVGNDPASKTYVDSKEKACAQVGIDSQVITLPEHTTESELLELIDQLNNDSSVHAILVQLPLPAHINKNNVIYSIKPEKDVDGFHPTNVGRLQLRDKKCLESCTPKGIMTMLREYGIKTEGAYAVVVGASNVVGKPVSQLLLNAKATVTTCHRFTTDLKSHTTKADILIVAVGKPNFITADMVKEGAVVIDVGINHVDGKIVGDVDFAAVKDKVAAITPVPGGVGPMTITELLYNTFQCAQELNR

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Francisella tularensis subsp. novicida (strain U112)

Length

282 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.431 kDa

Sequence

MILIDGKSLSKDLKERLATQVQEYKHNTAITPKLVAIIVGNDPASKTYVASKEKACAQVGIDSQVITLPEHTTESELLELIDQLNNDSSVHAILVQLPLPAHINKNNVIYSIKPEKDVDGFHPTNVGRLQLRDKKCLESCTPKGIMTMLREYGIKTEGAYAVVVGASNVVGKPVSQLLLNAKATVTTCHRFTTDLKSHTTKADILIVAVGKPNFITADMVKEGAVVIDVGINHVDGKIVGDVDFAAVKDKVAAITPVPGGVGPMTITELLYNTFQCAQELNR

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Francisella tularensis subsp. holarctica (strain OSU18)

Length

282 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.482 kDa

Sequence

MILIDGKSLSKDLKERLATQVQEYKHHTAITPKLVAIIVGNDPASKTYVASKEKACAQVGIDSQVITLPEHTTESELLELIDQLNNDSSVHAILVQLPLPAHINKNNVIYSIKPEKDVDGFHPTNVGRLQLRDKKCLESCTPKGIMTMLREYGIKTEGAYVVVVGASNVVGKPVSQLLLNAKATVTTCHRFTTDLKSHTTKADILIVAVGKPNFITADMVKEGAVVIDVGINHVDGKIVGDVDFAAVKDKVAAITPVPGGVGPMTITELLYNTFQCAQELNR

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)

Length

282 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.454 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Francisella tularensis subsp. tularensis (strain WY96-3418)

Length

282 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.454 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)

Length

282 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.546 kDa

Sequence

MAAQVLSGHEAAEAVYEEIRARLRSLSFTPSLRVIRLGEDPASVAYVRLKDKRARALGYRSQVEVYPEDLPEEALLERIAALNADEEVDGILVQLPLPPHIRTQRVLEAIHPLKDVDGFHPLNVGRLWSGGKGLFPCTPLGVVRLLKHYGVDLRGKEVVVVGRSNIVGKPLAGLLLREDATVTLAHSKTQDLPQVTRRAQVLVVAVGRPHLVRKEWVREGAIVVDVGVNRVEGRLLGDVHPEVAEVASALTPVPGGVGPMTVAMLMGNTLEAALLRRHGASG

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)

Length

282 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.608 kDa

Sequence

MAAQVLSGHEAAEAVYEEIRARLRSLSFTPSLRVIRLGEDPASVAYVRLKDKRARALGYRSQVEVYPEDLPEEALLERIAALNADEEVDGILVQLPLPPHIRTQRVLEAIHPLKDVDGFHPLNVGRLWSGGKGLFPCTPLGVVRLLKHYGVDLRGKEVVVVGRSNIVGKPLAGLLLREDATVTLAHSKTQDLPEVTRRAQVLVVAVGRPHLVRKEWVREGAIVVDVGVNRVEGRLLGDVHPEVAEVAFALTPVPGGVGPMTVAMLMGNTLEAALLRRHGASG

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Nitratiruptor sp. (strain SB155-2)

Length

282 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.812 kDa

Sequence

MQILDGKKLSQKIKESIKKEVEELKKEQDIIPGLAVILVGDDPASHTYVKMKARACKDVGIYSIVHEMPESISQKEIEETISMMNKNPNIDGILVQLPLPKHIDTTKILELIDPAKDVDGFHPYNFGRLMQGLDTFAPCTPLGVMELLDEYGIDVKGMNACVVGASNIVGKPMAALLLNRFATVDICHIYTKDLAEHTKKADIIAVGVGKPNLITADMVKERAIVIDIGINKVGNKIVGDVDFENVSKKASYITPVPGGVGPMTIAMLLKNTIKAAKQRKRS

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Acidovorax ebreus (strain TPSY)

Length

282 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.719 kDa

Sequence

MTAQLIDGNALSRQLRTEVAARTAALKSRGITPGLAVVLVGDNPASQVYVRNKVKACEDVGFHSVLEKYDASMSEEQLLARVQALNNDPSIHGILVQLPLPKHIDDHKVIEAISPLKDVDGFHVASAGALMVGQVGFKACTPYGCMKMLESIGMKDLRGKHAVVIGRSNIVGKPMAMMLLAANATVTVCHSGTADLAAMTRQADVVVAAVGKRNVLTADMVKPGAVVIDVGMNRNDEGKLCGDVDFEGVKQVAGYITPVPGGVGPMTITMLLVNTLEAAERL

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Acidovorax sp. (strain JS42)

Length

282 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.761 kDa

Sequence

MTAQLIDGNALSRQLRTEVAARTAALKDRGITPGLAVVLVGDNPASQVYVRNKVKACEDVGFHSVLEKYDASMTEEQLLARVQALNNDPSIHGILVQLPLPKHIDDHKVIEAISPLKDVDGFHVASAGALMVGQVGFKACTPYGCMKMLESIGMKDLRGKHAVVIGRSNIVGKPMAMMLLAANATVTVCHSGTADLAAMTRQADVVVAAVGKRNVLTADMVKPGAVVIDVGMNRNDEGKLCGDVDFEGVKQVAGYITPVPGGVGPMTITMLLVNTLEAAERL

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Clostridium botulinum (strain ATCC 19397 / Type A)

Length

282 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.696 kDa

Sequence

MAKILYGNEVALKIKEDLNLRIDKLKEKNIIPKLAILRMGNKPDDIAYERSIIKSCEKLNIETKVEELNEDILEEDFLKLMESLNNEKEIHGILVFRPYPKHLNENIINSSIALNKDVDCMHPLNLERIFEGDLNGFMPCTPEAVIEILKYYDIDLKGKNIVIINRSMVVGKPLSMMVLSHNATVTICHSRTIDLPSITKKADIVVTAIGKAKLIKEEYFNEDSIVMDVSINIDENGKLCGDVDFENVKEKVGAITPVPKGVGSVTTTLLLKHIVDAAERNS

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Clostridium botulinum (strain 657 / Type Ba4)

Length

282 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.594 kDa

Sequence

MAKILYGNEVALKIKEDLNLRIGKLKEKNIIPKLAILRMGNKPDDIAYERSIIKSCEKLNIETKVEELNEDILEEDFLKLMESLNNEKETHGILVFRPYPKHLNENIINSSIALNKDVDCMHPLNLERIFEGDLNGFMPCTPEAVIEILKYYDIDLKGKNIVIINRSMVVGKPLSMMVLSHNATVTICHSKTIDLPSITKRADIVVTAIGKAKLIKEEYFNEDSIVIDVSINVDENGKLCGDVDFENVKEKVGAITPVPKGVGSVTTTLLLKHIVDAAERNS

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Clostridium beijerinckii (strain ATCC 51743 / NCIMB 8052)

Length

282 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.001 kDa

Sequence

MGQIINGKEVALKVKEEIKNFVNNRKEKNLQVPKIASILVGNDGGSIYYMGSQEKVANSLGVEFLKLTLPETCNDEDVIAEINKLNEDNNIHGIILQLPLPNNFDEKKIIKQISPNKDIDCLTFESQGKLYMGEPKFLPCTPNSVITLIKSLNIDIVGKNVVVLGRSNIVGKPVAQLLLNENATVTICHSKTKNLREVCKNADILVVAIGRPKFIDETYVNENAIVIDVGTSSFEGKITGDVDFDKVIDKCRYLTPVPGGVGSLTTTLLIKNACEALQENEY

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Clostridium botulinum (strain Alaska E43 / Type E3)

Length

282 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.957 kDa

Sequence

MGQIINGKEVALKIKEEIKTFVEERKNNKLRIPKIASILVGNDGGSIYYMSSQEKVANSLGVDFLKIILEENVTDDDVINEIHKLNDDVNVQGIMLQLPLPKHLNEKKIIKEISVKKDIDCLTFESQGKLYMGEKGFLPCTPNSVVTLIKSLNVDITGKEVVVLGRSNIVGKPVAQLLLNENATVTICHSKTKNLKEVCSKADILVVAIGKPKFIDEEYIKENAIVIDVGTSSFEGKITGDVNFDKVIDKASFLTPVPGGVGALTTTLLIKNSCEALKEYED

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Clostridium botulinum (strain Eklund 17B / Type B)

Length

282 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31 kDa

Sequence

MGQIINGKEVALKIKEEIKTFVEERKKNKLRIPKIASILVGNDGGSIYYMSSQEKVANSLGVDFLKIILEENVTDDDVINEIHKLNDDVNVQGIMLQLPLPKHLNEKKIIKEISVKKDIDCLTFESQGKLYMGEKGFLPCTPNSVITLIKSLKIDITGKEVVVLGRSNIVGKPVAQLLLNENATVTICHSKTKDLKEVCSKADILVVAIGKPKFIDEEYIKENAIVIDVGTSSFEGKITGDVNFDKVIDKASFVTPVPGGVGALTTTLLIKNSCEALKEYED

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)

Length

282 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.696 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Clostridium botulinum (strain Kyoto / Type A2)

Length

282 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.688 kDa

Sequence

MTKILYGNEVALKIKEDLNLRIDKLKEKNIIPKLAILRMGNKPDDIAYERSIIKSCEKLNIETKVEELNEDILEEDFLKLMESLNNEKEIHGILVFRPYPKHLNENTINSSIALNKDVDCMHPLNLERIFEGDLNQFVPCTPEAVIEILKYYDIDLKGKNIVIINRSMVVGKPLSMMVLSNNATVTICHSKTIDLPSITKKADIVVTAIGKAKLIKEEYFNEDSIVMDVSINVDENGKLCGDVDFENVKEKVGAITPVPKGVGSVTTTLLLKHIVDAAERNS

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Clostridium botulinum (strain Okra / Type B1)

Length

282 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.685 kDa

Sequence

MTKILYGNEVALKIKEDLNLRMDKLKEKNIIPKLAILRMGNKQDDIAYERSIIKSCEKLNIETKVEELNEDILEEDFLKLMENLNNEKDIHGILVFRPYPKHLNENIINSSIALNKDVDCMHPLNLERIFEGDLDGVMPCTPEAVIEILKYYDIDLKGKNIVIINRSMVVGKPLSMMVLSNNATVTICHSKTIDLPSITKKADIVVTAIGKAKLIKEEYFNENSIIIDVSINVDENGKLCGDVDFENVKEKVGAITPVPKGVGSVTTTLLLKHIVEAAERNS

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Clostridium botulinum (strain Langeland / NCTC 10281 / Type F)

Length

282 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.659 kDa

Sequence

MTKILYGNEVALKIKEDLNLRIDKLKEKNIIPKLAILRMGNKPDDIAYERSIIKSCEKLNIETKVEELSEDILEEDFLKLMESLNNEKEIHGILVFRPYPKHLNENTINSSIALNKDVDCMHPLNLERIFEGDLNGFMPCTPEAVIEILKYYDIDLKGKNIVIINRSMVVGKPLSMMLLSHNATVTICHSKTIDLPSITKKADIVVTAIGKAKLIKEEYFNEDSIVMDVSINVDENGKLCGDVDFENVKEKVGAITPVPKGVGSVTTTLLLKHIVDAAERNS

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Clostridium botulinum (strain Loch Maree / Type A3)

Length

282 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.751 kDa

Sequence

MAKILYGNEVALKIKEDLNLRIGKLKEKNIIPKLAILRMGNKPDDIAYERSIIKNCEKLNIETKVEELNEDILEEDFLKLMESLNNEKETHGILVFRPYPKHLNENIINSSIALNKDVDCMHPLNLERIFEGDLNGFMPCTPEAVIEILKYYDIDLKGKNIVIINRSMVVGKPLSMMVLSHNATVTICHSKTIDLPSITKKADIVVTAIGKAKLIKEEYFNENSIVIDVSINVDENGKLYGDVDFENVKEKVRAITPVPKGVGSVTTTLLLKHIVDAAERNS

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Histophilus somni (strain 2336)

Length

282 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.617 kDa

Sequence

MPAQIISGTELSKNIKFNVAEKIQHYLQQGKRAPGLAVILVGADPASQVYVGSKRRSCEELGIYSKSYDLPAETTEQELLTLIEQLNQDPQIDGILVQLPLPEKINSTKVIEHISPTKDVDGFHPYNVGRLCQRIPTLRACTPLGIMKLLETTGVDLYGQHAVIIGASNIVGRPMALELLLAGCTVTVTHRFTKDLKSHVHQADILVVAVGKPHIIPGEWIKEGAIVIDVGINRVDGKLVGDVQYDEASKKASFITPVPGGVGPMTVAMLMFNTLLAYESHS

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Acinetobacter baumannii (strain ATCC 17978 / CIP 53.77 / LMG 1025 / NCDC KC755 / 5377)

Length

282 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.702 kDa

Sequence

MALVLDGRALAKQIEENLLVRVEALKAKTGRTPILATILVGDDGASATYVRMKGNACRRVGMDSLKIELPQETTTEQLLAEIEKLNANPDVHGILLQHPVPAQIDERACFDAISLAKDVDGVTCLGFGRMAMGEAAYGSATPAGIMTILKENNIEIAGKHAVVVGRSAILGKPMAMMLLQANATVTICHSRTQNLPELVKQADIIVGAVGKAELIQKDWIKQGAVVVDAGFHPRDGGGVGDIQLQGIEEIASAYTPVPGGVGPMTITTLIRQTVEAAEKALG

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Acidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / JCM 7670 / NBRC 15755 / NCIMB 13165 / 161)

Length

282 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.091 kDa

Sequence

MSAIVLDGKAYAKQLEGEMQERVERIRAKTNGEPPILATILVGSDPASATYVRMKGNACRRVGMDSLSVTLPEETTTEELLAKIDELNADERVRGILLQHPVPKQIDERACFDRISIDKDVDGVTTHGFGRMAMDEPAYGSATPAGIMRLLRHYQIPLEGKEAVVVGRSPILGKPMAMMLLAANATVTICHSRTKNLPDVIRRADIIVGALGKPEFIKGDWIRDGAVVVDAGYHPGGVGDIELSAVIGRCAAYTPVPGGVGPMTIATLIAQTVEAAEKAAGI

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Campylobacter jejuni subsp. jejuni serotype O:6 (strain 81116 / NCTC 11828)

Length

282 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.337 kDa

Sequence

MTLLDGKALSAKIKEELKEKNQFLKSKGIESCLAVILVGDNPASQTYVKSKAKACEECGIKSLVYHLNENTTQNELLALINTLNHDDSVHGILVQLPLPDHICKDLILESIISSKDVDGFHPINVGYLNLGLESGFLPCTPLGVMKLLKAYEIDLEGKDAVIIGASNIVGRPMATMLLNAGATVSVCHIKTKDLSLYTRQADLIIVAAGCVNLLRSDMVKEGVIVVDVGINRLESGKIVGDVDFEEVSKKSSYITPVPGGVGPMTIAMLLENTVKSAKNRLN

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Campylobacter jejuni subsp. doylei (strain ATCC BAA-1458 / RM4099 / 269.97)

Length

282 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.382 kDa

Sequence

MTLLDGKALSAKIKEELKEKNQFLKSKGIESCLAVILVGNNPASQTYVKSKAKACEECGIKSLVYHLNENTTQNELLALINTLNHDDSVHGILVQLPLPDHICKDLILESIISSKDVDGFHPINVGYLNLGLESGFLPCTPLGVMKLLKAYEIDLKGKDAVIIGASNIVGRPMATMLLNAGATVSVCHIKTKDLSLYTRQADLIIVAAGCVNLLRSDMVKEGVIVVDVGINRLESGKIVGDVDFEEVSKKSSYITPVPCGVGPMTIAMLLENTVKSAKNRLN

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)

Length

282 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.349 kDa

Sequence

MTLLDGKALSAKIKEELKEKNQFLKSKGIESCLAVILVGDNPASQTYVKSKAKACEECGIKSLVYHLNENITQNELLALINTLNHDDSVHGILVQLPLPDHICKDLILESIISSKDVDGFHPINVGYLNLGLESGFLPCTPLGVMKLLKAYEIDLEGKDAVIIGASNIVGRPMATMLLNAGATVSVCHIKTKDLSLYTRQADLIIVAAGCVNLLRSDMVKEGVIVVDVGINRLESGKIVGDVDFEEVSKKSSYITPVPGGVGPMTIAMLLENTVKSAKNRLN

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Campylobacter jejuni subsp. jejuni serotype O:23/36 (strain 81-176)

Length

282 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.337 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Campylobacter jejuni (strain RM1221)

Length

282 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.352 kDa

Sequence

MTLLDGKALSAKIKEELKEKNQFLKSKGIESCLAVILVGDDPASQTYVKSKAKACEECGIKSLVYHLNENTTQNELLALINTLNHDDSVHGILVQLPLPDHICKDLILESIISSKDVDGFHPINVGYLNLGLESGFLPCTPLGVMKLLKAYEIDLEGKDAVIIGASNIVGRPMATMLLNAGATVSVCHIKTKDLSLYTRQADLIIVAAGCVNLLRSDMVKEGVIVIDVGINRLESGKIVGDVDFEEVSKKSSYITPVPGGVGPMTIAMLLENTVKSAKNRLN

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Cenarchaeum symbiosum (strain A)

Length

282 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.676 kDa

Sequence

MDGKAVAAAVKERVKMAVAELKSGGTDPCLATVLVGDDPASGTYVRNKHAACAEVGITTQDHRLGPSTTEGDLLKLIAELNSDRSVHGILVQMPLPEGIREIKVVSAISPLKDVDGLTPLNAGLLTAGTATLIPCTPLGIMEMLDYYNIELEGKEVVLINRSRLVGIPLHHLFLGRNATVTTCHSRTKDIGSISRRADVIVTAVGNRDKFVLTPDMVKEGAVVIDVAISRSDRGLTGDADYAAVSEKASHITPVPGGVGPMTVAMLLKNTTTAASLVKSLER

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Lactobacillus gasseri (strain ATCC 33323 / DSM 20243 / JCM 1131 / NCIMB 11718 / AM63)

Length

282 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.41 kDa

Sequence

MKKLLEGKTPANEITENLKKEIKNLKNDGINPTLCVIEVGDDPASKIYLRVKRNLAKKVGINEVGLHFPADTSQAELLGKIKELNQDPNINGIMVQLPVPPQIDPRAIFETIAPEKDADGFSPLNLGRLWEGQSDIIPATVRSILTLIDYYGIKMAGKNTVIIGRSVIVGKPLAAVLLERDATVTIAHSKTKNLADLTRNADVIISDVGKAHLVTEDMVKDGAVLIDVGMNRENGKLMGDVDFDTVAPKANAITPVPGGVGPLTVASLMKQAVILTRKQHGR

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Lachnoclostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg)

Length

282 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.589 kDa

Sequence

MAMIIDGKRISGEIKDELKAEVSELKSQGKEVTLAVIQVGTDPASTVYVGNKKKACEYCGIRSLAYELPLETTEEELLNLINELNDRDDVTGILVQLPLPDHIEENKVIKTIDPKKDVDGFHPESVGALSIGQAGYLSCTPAGIVQLLKRSGIEIEGKECVVLGRSNIVGKPMALLLLRENGTVTICHSKTKNLSEITKRADILVVAIGKPRFLTKEYVKDGAVVIDVGMHRDENNKLCGDVDYDDVVDKVSAITPVPGGVGPMTIAMLMNNCVYGAKKFQI

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Brachyspira hyodysenteriae (strain ATCC 49526 / WA1)

Length

281 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.888 kDa

Sequence

MSNILDGRELAKEIKERIKKETEILEKKPRIDFLYFEDDKSTEVYFTRAKKQAESVGMIGSLHNLPVNTTEKDFLTLIEYLNEESETSGIMIQMPLPKHISKKKVYETISIEKDADAISHVNLGRIFIGDSNLAPCTAKSAMALIEKSGINIEGANAVVIGRSEIVGKPLAHLLLQKSATVTIAHSKTKNLKELCKNADILCVSIGKAEFITGEYIKEGAVVIDVGINVLEDGSLKGDVNFEEASKLASYITPVPNGVGSVTVSMLLDNVLYLHKNIINKK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Anaeromyxobacter sp. (strain Fw109-5)

Length

281 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.599 kDa

Sequence

MIIDGKLIAAKVRGEVAEAVRALKASGVAPGLSVVRVGDDPASAIYVRGKRKDCEEVGIRSDEHHLPATVSQADLLALVARLNADPTVHGILVQLPLPKHLDERAVLDAIDPRKDSDGFHPFNVGALSIGIPGTPRPCTPAGVMRLLDEARVDPKGKRAIVVGRSNIVGKPMAAMLLERHATVTIAHSRTQDLAGEVARADIVVAAIGKAELIRGEWIREGAVVIDVGMNRLDDGRLVGDVEYAAAARRASAITPVPGGVGPMTRAMLLVNTIELARSGAR

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)

Length

281 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.086 kDa

Sequence

MSAIKLDGNLYRDEIFEDLKGRVNSLREKGIVPGLATVLVGDDPASHAYVRMKHKDCEIVGVKSIRKDLPADVTQEELLAVIDDLNADPECTGYIVQLPLPKHLDENAVLERIDPAKDADGLHPVNLGKLVLNEPAPLPCTPNGAIHLLRRFGVELDGKKVVVIGRGVTVGRPIGLMLTRRSENSTVTLCHTGTRDLAAETREADVIVAAAGKAHMLTADMVKQGAAILDVGVSRVDGKLLGDVHPDVWDVAGAVSPNPGGVGPLTRAFLIRNVVERAERA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)

Length

281 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.453 kDa

Sequence

MGAIMLDGKATRDEIFGDLKPRVAALDAAGRTPGLGTILVGDDPGSQAYVRGKHADCAKVGITSIRRDLPADISTATLNETIDELNANPDCTGYIVQLPLPKHLDENAALERVDPAKDADGLHPTNLGRLVLGTPAPLPCTPRGIVHLLRRYDISIAGAHVVVIGRGVTVGRPLGLLLTRRSENATVTLCHTGTRDLPALTRQADIVVAAVGVAHLLTADMVRPGAAVIDVGVSRTDDGLVGDVHPDVWELAGHVSPNPGGVGPLTRAFLLTNVVELAERR

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Mycobacterium bovis (strain BCG / Pasteur 1173P2)

Length

281 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.453 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Mycobacterium bovis (strain BCG / Tokyo 172 / ATCC 35737 / TMC 1019)

Length

281 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.453 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Mycobacterium marinum (strain ATCC BAA-535 / M)

Length

281 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.727 kDa

Sequence

MGAITLDGKATRDEIFVDLKQRVSELNASGRTPGLATILVGEDPGSQAYVRGKHSDCAKVGITSIRRDLPADISTATLNETIDELNANPDCTGYIVQLPLPKHLDENAALERIDPGKDADGLHPTNLGRLVLNTPAPLPCTPRGIVHLLRRYDVPIAGAHVVVIGRGVTVGRPLGLLLTRRSENATVTLCHTGTRDLPTLTRQADIIVAAVGVPHMLTADMVRPGAAVVDVGVSRVDGKLTGDVHPDVWEVAGHVSPNPGGVGPLTRAFLLTNVVELAEQR

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)

Length

281 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.539 kDa

Sequence

MGAITLDGKATRDEIFVDLKQRVAALTAAGRTPGLGTILVGDDPGSQAYVRGKHADCAKVGITSIRRDLPADISTAALNDTIDELNANPECTGYIVQLPLPKQLDENAALERVDPDKDADGLHPTNLGRLVLNNPAPLPCTPRGIVHLLRRYDAEIAGAHVVVIGRGVTVGRPLGLLLTRRSENATVTLCHTGTRDLPALTRQADIIVAAVGVPHLLTADMVRPGAAVLDVGVSRVDGKLAGDVHPDVWEVAGHVSPNPGGVGPLTRAFLLTNVVELAERE

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Anaeromyxobacter sp. (strain Fw109-5)

Length

281 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.599 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)

Length

281 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.086 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)

Length

281 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.453 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Mycobacterium bovis (strain BCG / Pasteur 1173P2)

Length

281 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.453 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Mycobacterium bovis (strain BCG / Tokyo 172 / ATCC 35737 / TMC 1019)

Length

281 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.453 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Mycobacterium marinum (strain ATCC BAA-535 / M)

Length

281 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.727 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)

Length

281 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.539 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Dictyoglomus turgidum (strain Z-1310 / DSM 6724)

Length

281 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.034 kDa

Sequence

MGVILEGKPVAEKLEKEIKEKIQFYKSQGVIPTLCIVKVGKNAEAEAYAKSIEKFFSKIGINIERKNFNEEISLVDFKKIMKELEEDSAIHGVLILRPLPEELERGKAFQFLPTKKDVEGVTYENLGRLLVGEDSFHPCTPQAVLELLDFYQIPVEGKNVVVVGRSISVGKPLSLLLLNRNATITVCHSKTKNLVEFTKKAEILIVAIGKPYFVGKDMVGEGQVIIDVGTNVVDGKLVGDVNFEEVKDKVEYITPVPGGIGVITTRVLAMNLLKAVKKVEA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)

Length

281 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.484 kDa

Sequence

MGAIMLDGKATRDEIFGDLKQRVAALDAAGRTPGLGTILVGDDPGSQAYVRGKHADCAKVGITSIRRDLPADISTATLNETIDELNANPDCTGYIVQLPLPKHLDENAALERVDPAKDADGLHPTNLGRLVLGTPAPLPCTPRGIVHLLRRYDISIAGAHVVVIGRGVTVGRPLGLLLTRRSENATVTLCHTGTRDLPALTRQADIVVAAVGVAHLLTADMVRPGAAVIDVGVSRTDDGLVGDVHPDVWELAGHVSPNPGGVGPLTRAFLLTNVVELAERR

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)

Length

281 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.484 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

Length

281 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.484 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Mycobacterium ulcerans (strain Agy99)

Length

281 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.701 kDa

Sequence

MGAITLDGKATRDEIFVDLKQRVSELNASGRTPGLATILVGEDPGSQAYVRGKHSDCAKVGITSIRRDLPADISTATLNETIDELNANPDCTGYIVQLPLPKHLDENAALERIDPGKDADGLHPTNLGRLVLNTPAPLPCTPRGIVHLLRRYDVPIAGAHVVVIGRGVTVGRPLGLLLTRRSENATVTLCHTGTRDLATLTRQADIIVAAVGVPHMLTADMVRPGAAVVDVGVSRVDGKLTGDVHPDVWEVAGHVSPNPGGVGPLTRAFLLTNVVELAEQR

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Sulfurovum sp. (strain NBC37-1)

Length

281 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.222 kDa

Sequence

MQLIDGKSLAHKVQENVAKEVEELKQVKNIVPGLAVLLIGDDPASHAYVNMKAKACERVGFYSITHNMPDTISQDEIIATIEMMNANPRIDGILVQLPLPKHIDTNKILEVIDPKKDVDGFHAYNVGRLVTGLDSFVACTPLGVMKMFEEYEIDLEGKDVCVVGASNIVGKPMASLLLNANATVTITHIFTKDLKAHTSQADIVVVGVGVPGLIKEDMVKEGAIVIDIGINRIEDGSLVGDVDFKNVAPKCSYITPVPGGVGPMTIAMLLSNTLKSAKQRA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Polaromonas sp. (strain JS666 / ATCC BAA-500)

Length

281 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.7 kDa

Sequence

MTAQLIDGNALSRQLRAEVARRAAALRARGITPGLAVVLVGENPASQVYVRNKVKACQDNGLHSVLEHYPAALSEAELLARVHALNNDPAIHGILVQLPLPAHIDAHKVIEAIAPGKDVDGFHVASAGALMVGQPGFWPCTPYGCMKMLESIGYDLRGKHAVVIGRSNIVGKPMAMMLLQKNATVTICHSATKDLKAMTLQADVIVAAVGKRNVLTADMVKPGAVVIDVGMNRNDEGKLCGDVDFEGVKEVAGYITPVPGGVGPMTITMLLVNTLESAERL

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)

Length

281 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.006 kDa

Sequence

MAVKLLKGEEIAEKKAEELKERIEKMGVSPRLVLLQVGNYSAATIYARAKIKRGKKIGADVVLEKYEDLTKQELVRRIEELSADKDVNGIMVENPLPKTIDYYDIVKSIPYYKDVDALSPYNQGSIAINREFLVPATAMAVVDILKYYGYEKTTATIINRSPVVGRPLSMMMLNRDYTVSICHSKTPDIRSIAKASKIIVVAVGRPGFLDDTYVTESSVVIDVGINYVQDKVIGDIDFDKVSEKVEAVTPVPGGVGPITATNILSNLVKAAEYQSNTNIGR

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Alcanivorax borkumensis (strain ATCC 700651 / DSM 11573 / NCIMB 13689 / SK2)

Length

281 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.12 kDa

Sequence

MTAQILDGKTLAQQFEQEMRLRVDVLKAKANGHTPILATILVGADPASATYVKMKGNACQRVGMESVAIELSEETTTAQLLAKIDELNNNQDVHGILLQHPVPAQIDERACFDAISLEKDVDGVTCLGFGRMSMGEAAYGCATPKGIMRLLEHYQVELEGKHAVVVGRSAILGKPMAMMMLEANATVTICHSRTQNLPELVKQADIVVGAVGKPEFIKADWIKDGAVVVDAGFHPERCGDIELAPLVDRVAAYTPVPGGVGPMTINTLIFQTLQSGEKAFG

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Mycobacterium avium (strain 104)

Length

281 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.553 kDa

Sequence

MGAITLDGKATRDEIFVDLKQRVAALTAAGRTPGLGTILVGDDPGSQAYVRGKHADCAKVGITSIRRDLPADISTAALNDTIDELNANPECTGYIVQLPLPKQLDENAALERVDPDKDADGLHPTNLGRLVLNNPAPLPCTPRGIVHLLRRYDVEIAGAHVVVIGRGVTVGRPLGLLLTRRSENATVTLCHTGTRDLPALTRQADIVVAAVGVPHLLTADMVRPGAAVLDVGVSRVDGKLAGDVHPDVWEVAGHVSPNPGGVGPLTRAFLLTNVVELAERE

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Mycobacterium abscessus (strain ATCC 19977 / DSM 44196 / CIP 104536 / JCM 13569 / NCTC 13031 / TMC 1543)

Length

281 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.721 kDa

Sequence

MTATRLDGKATRDEIFVELATRAAALKAAGKTPGLGTILVGDDPGSHAYVRGKHADCAKVGLNSIRRDLPADIDQATLCATIDELNANPDCTGYIVQLPLPKHLDENEALERIDPDKDADGLHPTNLGRLVLGKEAPLPCTPRGIVYLLRRYDVKLDGAHVVVIGRGVTVGRPLGLLLTRRSENATVTLCHTGTRDLAALTRQADIIVAAAGVPHMVTADMVKPGAAVVDVGVSRVDDKLTGDVAEDVWDVAGYVSPNPGGVGPLTRAFLLTNVIERAERS

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Enterococcus faecalis (strain ATCC 700802 / V583)

Length

281 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.955 kDa

Sequence

MSTVINGRELADQMQAEIQKDVEKMTQQGIQPGLVVLLVGENPASQTYVRNKERAAAKIGILSKVEKLPETISEEELLAEIDKYNQDSRFHGILVQLPLPKHIDEEKILLAIDPKKDVDGFHPMNLGRLFVGKPEMIPCTPYGIMKMFEAYDIDLTGKRAVVIGRSNIVGKPMAQLLLMKNATVTIAHSKTEHLAEVAKEADILVVAIGRGHFVTKEFVKPGAVVIDVGMNRNQEGKLIGDVAFDEVSEIASYITPVPKGVGPMTITMLMYQTVEAAKKQK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Pelagibacter ubique (strain HTCC1062)

Length

281 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.666 kDa

Sequence

MILIDGKKIAAELREQLRQEVVELKAKHNKIPGLTVILIGEMAPSQIYVRMKEKAANEVGLKSEVIRYPEAVEEKTVLDKIEELNKDESISGILVQLPLPKHIDKQKVIETILPGKDVDGFHPMNVGNLSSGYESSVPCTPLGCYLMIKKIEPNLSGKKAVMIGRSNLNGKPMAQLLLKENCTVTITHSKTKDLKAECLEADIIVAAVGIPELVKADWVKKDAIVIDVGINKTENGIVGDVAFEEVSKVARALTPVPGGVGPMTIACLLKNTIECFKRSQK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Polaromonas naphthalenivorans (strain CJ2)

Length

281 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.719 kDa

Sequence

MTAQLIDGNALSRQLRTEVAQRAALLRARGITPGLAVVLVGDNPASQVYVRNKVKACEDNGLHSVLERYPAEMSEADLLARVEALNNDPAIHGILVQLPLPAHIDAQKVIEAISPAKDVDGFHVGSAGALMVGQPGFWPCTPYGCMKMLESIGYDLRGKHAVVIGRSNIVGKPMALMLLQKNATVTICHSATADLKAMTLQADVIVAAVGKRNVLRADMVKPGAVVIDVGMNRNEEGKLCGDVDFDGVKEVAGYITPVPGGVGPMTITMLLVNTLEAAERG

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Mycoplasma mobile (strain ATCC 43663 / 163K / NCTC 11711)

Length

280 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.809 kDa

Sequence

MIILDGKKLSQKDTIFLKEKVNQFKIKPVFTIVQVGNLFSSNKYIKTKMDKALEIGVVSRLIKIPESISEKDLISIIEEESKISHGLIVQLPLPLQFDQSKILNSVPITKDIDGLSEKNSKNLYSGKSCIQPATARGIIDLIKEYNFTIKDKKVYVIGESNLVGKPIKELFKQAGAIVKSFNINTGIKGSEEADILIVAAGHPNLVKPENVKNNSIVIDVGINSIGENDKMIVTGDVDFSNVKTKVKAISPVPGGVGPMTVISLFKNLIEIFEKYLLDDN

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Mycoplasma mobile (strain ATCC 43663 / 163K / NCTC 11711)

Length

280 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.809 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4)

Length

280 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.996 kDa

Sequence

MKRMIIDGKEISNRIKEEVKREIQEFGYKPRLAILMAGDDESSKVYANSKVKACESVGIEAKVYYFSEKEEDKFFDTLEKLNEDKDTHGIMIEMPLPKGFDVDKVYDTINPYKDVDCISNYNMGRLFAGKPLFVPCTPKAIIHILENTGVDLEGKHAVVIGRSNILGKPVAKLLLDKNCTVTVCHSKTKDLAYHTKQADVLVVAAGKMNLVRGDMVKEGVVLIDAGINVHEGKIYGDADFESIKDKASYVTPVPGGVGPVTTAMILKNTLEAFKYAVKSL

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Geobacter daltonii (strain DSM 22248 / JCM 15807 / FRC-32)

Length

280 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.881 kDa

Sequence

MAKIIDGKAIAAKIRGEITAEVAKLAAQGITPGLAVVLVGEDPASKVYVSMKEKACKDVGIFSDEYKLPAETTEEELLQLIDKLNKDRKIHGILVQLPLPKQINTEKVLEAISPEKDADGFHPYNVGRLVIGKPLFQPCTPYGVMVMLKETGVDLAGKEVVVVGRSNIVGKPVAFMCLQQNATVTLCHSKTRDLAAKVAMADVVIAAVGQPEMIKGAWIKKGAVVIDVGVNRVGEKKLVGDVEYEAASARASAITPVPGGVGPMTITMLLYNTLESAKRR

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Geobacter uraniireducens (strain Rf4)

Length

280 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.7 kDa

Sequence

MAKIIDGKAIAAKIRGEITAEVAKLASKGVTPGLAVVLVGEDPASKVYVSMKEKACKDVGIFSDEYKLPVDTSEADLLLLIHKLNSDPKIHGILIQLPLPKQIDTEKVLEAISPEKDADGFHPYNVGRLVIGKPLFQPCTPYGVMVMLKEAGVELAGKEVVVVGRSNIVGKPVAFMCLQQNATVTLCHSKTRDLAAKVGMADVVIAAVGQPEMIKGAWIKEGAVVIDVGVNRVGEKKLVGDVEFDAAAERASAITPVPGGVGPMTITMLLYNTLEAAKRR

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Marinomonas sp. (strain MWYL1)

Length

280 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.774 kDa

Sequence

MTALVLDGKLCAKETENRLQAQVTELKERTGCTPILATILVGADPASATYVKMKGNACRRVGMDSMAIELPESTTTEQLLDKINELNNNPDVHGILLQHPVPAQVDERLCFDAIAAHKDVDGVTCLGFGRMAMKEPAYGAATPAGIMRLLAAYDIQLEGKHVVVVGRSPILGKPMAMMMLNANATVTMCHSRTQNLPEFVKQADVIVGAVGKPELIKADWIKDGAIVVDAGYHPGGIGDIELGPLKDRVAAYTPVPGGVGPMTINTLILQTLESGLKQLG

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Methanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c)

Length

280 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.842 kDa

Sequence

MIIDGKRVSEKRLELIKEEIDESGLYPRLATVIAGDNPASLLYVQMKHRACERVHIGSISITLPGDSTTAKVLETIDRLNKDPEINGILVQLPLPAGVDTEQVIEAILPEKDVDGFHPFNLGKLLGGSPTFAPCTPLGIMTLLKEYKIDPAGKRAVVIGRSIDVGRPMAALLINANATVTVCHSRTKDLAAELRKADIIVSAMGKARFITGDMVSGDAVVIDVGINHVDGKLCGDVDFASVSEKVAAITPVPGGVGPMTIATLMENTFKAAKMQSCRTVH

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT)

Length

280 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.939 kDa

Sequence

MIIDGKALASDIEAEVRERVERLGFNPGLATILVGENPASQMYIRIKHAACERVGIRSENIVLPGDTDESTLIKTIQGLNKRGDVHAILLQLPLPGHLDPRKAMMAISPEKDADGFHPENMGALLLGAERLVPCTPRGIVYALEHLGVDIEGSEAVIVGHSNVVGKPLAAMLLNRNATVQVCHVYTRNLKEHTKDAEILVVAAGVPRLIKADMVRDGAYVFDVGINKVDGKTVGDVDFDAVKEKAAGITPVPGGVGPLTVAMLLSQTVTAAEMSLERQRS

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Moorella thermoacetica (strain ATCC 39073 / JCM 9320)

Length

280 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.963 kDa

Sequence

MPAQILDGKKIAAEVRAEVKEEVSRLKAEGINPGLAVVLVGEDPASQVYVRNKHRACEEVGIYSEVHRLPAATSQAELLKLIDQLNKDPKIHGILVQLPLPDHIDEKKVIDAIALEKDVDGFSPANVGNLVIGDKCFYPCTPHGCMVLLEKAGIDPKGKKAVVVGRSNIVGKPVAMMLLARHATVTICHSRTRDLAAECRQADILIAAVGKPELITGDMIKEGAVVIDVGINRVGEKKLVGDVHFESAAQKAGWITPVPGGVGPMTIAMLLKNTVEAARR

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Cellvibrio japonicus (strain Ueda107)

Length

280 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.786 kDa

Sequence

MSALVLDGKALAAKTEQELSQRVTALKARNGQTPILATILVGDDPASATYVKMKGNACTRIGMESIKVELPSSTTTEELLAKIQELNDNPNVHGILLQHPVPHQIDERLCFDAIAPEKDVDGVTCLGFGRMAMGEEAYGCATPKGIMRLLEAYNIEIAGKHAVVVGRSPILGKPMAMMLLNANATVTICHSRTRNLPDLIKQADIIVGAVGKPEFIKAEWIKDGAVVVDAGYHPGGVGDIELGPLVERAAAYTPVPGGVGPMTINTLIYQSVDSGEKKIR

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Saccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024)

Length

280 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.473 kDa

Sequence

MSALILDGKALAKKTEDELTQCVDKLKASSGHTPILATILVGDDPASATYVKMKGNACSRIGMESLKVEMPTSTTTEQLLAKINELNANPAVHGILLQHPVPEQIDERACFDAIALEKDVDGVTCLGFGRMAMGEEAYGCATPKGIMRLLEAYNIELNGKHAVVVGRSPILGKPMAAMLLNANATVTICHSRTQNLEAHIKQADIVVGAVGKPEFIKAEWIKDGAVVVDAGYHPGGVGDIELAPLADRAAAITPVPGGVGPMTINTLIYQTVDSAQKKLG

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Teredinibacter turnerae (strain ATCC 39867 / T7901)

Length

280 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.347 kDa

Sequence

MSALILDGKALAQKTEAELSERVAALKSKTGRTPILATILVGGDPASATYVRMKGNACTRIGMDSMKVELPETTTTDELLAKIAELNNNPDVHGILLQHPVPSQIDERACFDAIDLSKDVDGVTCLGFGRMAMGEEAYGCATPKGIMRLLEAYEIPLEGKHAVVVGRSPILGKPMALMLLNANATVTICHSRTKDLQSHIATADIVVGAVGIPEFIKADWIKPGAVVVDAGYHPGGVGDIELGPLADKASALTPVPGGVGPMTINTLIYQSVDSGEKKLA

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Agathobacter rectalis (strain ATCC 33656 / DSM 3377 / JCM 17463 / KCTC 5835 / VPI 0990)

Length

279 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.01 kDa

Sequence

MANLIDGKLISTQIKDELKEEVTELKKKGIEGCLAVIQVGNDPASSVYVRNKKKACEYVGIKSLSYELAEETTEDEILKLIEKLNADSSVNGILCQLPLPKHIDEDKVIDAIDPKKDVDGFSPQSVGAMVIGKPGFLPCTPAGIIQLLKRSNIDIDGKSCVVVGRSNIVGKPMSLLMLRENATVTVCHSHTKDLKDVCKNADILIVAIGKPKFIDASYVKDGAVVIDVGIHRNAENKLCGDVDFDSVVSKASHITPVPGGVGPMTIAMLMSNCVEAMKR

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)

Length

279 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.55 kDa

Sequence

MILDGKGLAARRLELLKEDIIEGGLSPTLATVIVGDDPASHMYVRMKHRACEQVGISSVNISLPEDTTTRTILERIRQLNEDPDIDGILVQLPLPKSIDTEAVLAAILPEKDVDGFHPLNMGRLVTGLPGPRPCTPNGIMTLLHENKISIAGKRAVVVGRSVDVGRPIALLLLHADATVTMCHSKTENLKEITKQADILVSAAGKAGIITADMVKPGATVVDVGTNQVNGKLCGDVAFDEVEKIAGAITPVPGGVGPMTIASLMENTADIARNRCGHFM

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)

Length

279 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.997 kDa

Sequence

MSAVLLDGKALAAKKRDELKSEVTKLKERGITPGLAVILVGNDPASTVYVRSKQKACEQIGIYSVLKELPASTSEEELLTEIDRLNNDPTIHGILVQLPLPEQISEQAVIERISPAKDVDGFHPISVGRMMIGEDTFLPCTPFGVLVMLQEANVEIAGKHVVVVGRSNIVGKPVGQLMLNEHATVTYCHSRTKNLTEITKQADILIVAVGRARFIDASHVKEGAVVIDVGINRVDGKLCGDVDFESVREVASHLTPVPGGVGPMTITMLLANTIQAAKE

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Bacillus clausii (strain KSM-K16)

Length

279 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.829 kDa

Sequence

MAEPMILDGNDVSKRIKDKLALQVAALEQKGVRPCLATILVGDDPASATYVRMKGNACKRLGIESKKIELPKETTTKELLAVIRELNNDSSVHGILLQHPVPSQIDERAAFDEIAIEKDVDGVTTLGFAQNAFGFAHYPSCTPAAILAILDHYQLPIEGKHAVVVGRSPILGKPVSQMLLNRNATVTICHSRTENVSDFVEKADIVVAAVGKPNFIQGEWIKSGAVVLDAGYNKGNIGDCEYDGCAQRASAITPVPGGVGPVTISMLLKHTVEAAERSV

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Acidiphilium cryptum (strain JF-5)

Length

279 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

28.214 kDa

Sequence

MAARVIDGKAVAAALRAEVAARAATLPYAPGLAVVLVGEDPASQVYVRNKERAAKAAGFASETIRLPASASQAELLALIARLNHDPAVDGILVQLPLPAGIDPQAVIRAIDPAKDVDGFHPDNVAALALGTPFLVPCTPRGVMKLLAAAGIAPRGARALVLGRSNIVGRPMAALLLAADATVTIAHSRTRDLAAECRRAEILIAAVGRAEMVRGDWVSPGATVIDVGINRTAAGGLVGDVAYAEAAAVAGAITPVPGGVGPMTIACLLENTLIAAAARR

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Caldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903 / Tp8T 6331)

Length

279 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.568 kDa

Sequence

MAQRIKEEVKSEIEKLKEKGIESTLAVVIVGNDPASRSYVNSKKRTCLELGINSVEYALDTTTTQEQLENLIEKLNQDPKINGILVQLPLPNGLDESRVCKKILPQKDVDGFHPMNVGMLATGIDFEYSIKPCTPFGVIELLKRENIEIKGKHAVVIGRSNIVGKPLALLLLRENATVTICHSYTRDLKDICKTADILVAAVGKPKFVTADMVKEGAVVIDVGINRDETTKKIVGDVDFETVRRVASYITPVPGGVGPMTVAMLMKNTLFATLLQNGLI

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Mycoplasma synoviae (strain 53)

Length

278 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.128 kDa

Sequence

MKILSGREKAEQDLKQLKKELDELNLNRPIKLAIIQVGDKMESNRYVEQKLKKAKEIGIEAKCFKFDENITQKRLLLAMDEINENWDGILIQLPLPKHLPKEVILDAVPYEKDIDGLSHRNEFILYNEKNSDDKFFVPAAARAVLELIEHHEINYKKKKVAVVGRSHLVGKPVAHILKRRGASVSTFDENTPIKLVASADIVIVAIGVPKYIKAENIKQGAIIIDVGTNYDQNDPSVIFGDVDHESVKTKASAITPVPGGVGPLTVVCLLKNLVEIYK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Mycoplasma synoviae (strain 53)

Length

278 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

31.128 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)

Length

278 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.346 kDa

Sequence

MGDIINGKAESQKYKDKIIEFINERKKQGLDIPCIASITVGDDGGSLYYVNNQKKVSESLGIEFKSIFLDESIREEELIKLIEGLNVDNKIHGIMLQLPLPNHIDAKLVTSKIDANKDIDSLTDINTGKFYKGEKSFIPCTPRSIINLIKSLNVDICGKNAVVIGRSNIVGKPTAQLLLNENATVTICHSRTQNLKDICKKADIIVSAIGRPGFITDEFVNEKSIVIDVGTTVVDGKLRGDVVFDEVIKKAAYVTPVPGGVGAMTTTMLILNVCEALK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Clostridium novyi (strain NT)

Length

278 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.224 kDa

Sequence

MGIKIDGKRLAQDIREELKKQVENINNNEDVKLCMANILVGNDGGSQFYVRNQNKLCHALGIKVKNINLDECIKEEELLNIINELNNDNEVKGIILQLPLPKHLDESKITSAIDINKDIDGLSSISVGKLYKGEKCFVPCTPRGIIELIKTCDIDIEGSNAVVIGRSNIVGKPVAQLLLNENATVTICHSKTKNLKEICLNADILVSAIGKPHFITKDYVKEGAVVIDVGTSSVNGKMVGDVCFDEVIEKAAYVTPVPGGVGAMTTTMLIKNLCEGLK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Clostridium tetani (strain Massachusetts / E88)

Length

278 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.625 kDa

Sequence

MAVAIDGKRVSEELRKELKNFIDERVEKGLKVPCVSSILIGNDKGSLFYIKNQRRICKEIGIEFKNIVLEENIEEDKIIEVIEDLNKDENVHGIILQMPLPKTLDEEKIVNKICPSKDIDGLTDINAGRFYKGEKCFIPCTAQGIIEIIKSTKESISGKKAVVLGRSVIVGKPVAQLLVNEDATVTICHSKTKDIKSLCKEADIIVSAMGIPKFVKEDFIKDGAIVIDVGFSVLDGKMVGDIDYDNVFKKAGFITPVPGGVGSVTPTMLIKNLCEVFK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8)

Length

278 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.537 kDa

Sequence

MVTILDGKAVSEKRLELLKETISESGLYPRLATVIVGSDPASQMYVRMKHRACERVGIGSVGIEIPGDATTQNVLESVTRLNRDTDINGILIQLPLPKRVDTERVIAAVNTEKDVDGFHPTSLGLLMSGRPRFAPCTPKGIMNLLAEYHITVAGARAVVAGRSIDVGRPMAALLTNADATVTICHSRTRDLPAELRQADILVSAVGKAHFITPEMVKPGAVVIDVGINQLNGKLVGDVDFEAVKEVASAITPVPGGVGPMTIATLMENTFAAAAMRMP

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Hydrogenobaculum sp. (strain Y04AAS1)

Length

278 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.439 kDa

Sequence

MNILDGKSLAKKIKHNIKQEVKHLERKPKLVVVLVGDDQASLVYVKNKVQACADVGFSSQLDMFEKDVEEDVLLNHIKSLNEQEDVDGILVQLPLPSHISMQKVIDTIDPSKDVDGFHPQNMGKLFSGDLENAFIPCTPLGIKLLLDEYNIDLKGKNVCIVGAGFIVGKPLSMLMLNYDATVSVCHKYTKDIVEYTKTADILISATGVPFLIKDYMVKEGAVVIDVGISKVNGKIVGDVDFESISQKASFITPVPGGVGPMTVATLLLNTLKAYKQRI

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Exiguobacterium sp. (strain ATCC BAA-1283 / AT1b)

Length

278 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.003 kDa

Sequence

MAVVIDGKQVAASYRETLKERVAELRARGIVPKLKVVLIGDDPASHSYVRGKERAAEEIGIDSQVLRFDETISEKELLDLIDLMNADEEVHGILVQLPLPKHIDESRVIMRISPEKDVDGFHPENVGKMMLGLDTLLPCTPHGILHLAKTQTEIAGKHVVVVGRSQIVGKPVGMLFLNESATVTYCHSKTADLGEMTRQADILIVAVGRAGLVTSDMVKPGALVIDVGVNRVEGRLVGDVDYEAVKEKASAITPVPGGVGPMTITMLMHNTVEVASRG

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Vesicomyosocius okutanii subsp. Calyptogena okutanii (strain HA)

Length

277 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.244 kDa

Sequence

MNVINGKKIAQNLQASIKLKVDTLDRKPGLAVILVGDDDASEVYIRNKEDACKEVGFYLEIINRFDNISQEELLFEIERLNHDDKIDGILVQLPLPKHLDVNLVIETISPKKDVDGFHSENIGKLMQNKPFLHPCTPKGVMLMLESIEIDLVGKNCVVVGASNIVGRPMACELLNAKATVTICNSKTKNLSCKLIQADIVVVAVGIPKMIQSDWIKPGAIVIDVGINRLDNGCLVGDVDFESVRKVAGWIAPVPGGVGPMTIATLLKNTLTAYEARI

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Clostridium perfringens (strain ATCC 13124 / DSM 756 / JCM 1290 / NCIMB 6125 / NCTC 8237 / Type A)

Length

277 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.378 kDa

Sequence

MDKILSGKTVAIDIKGQIKNYTEELKASGKSLKISSILVGDDGGSVYYQNFQEKLANNLGIDFEKIKLDESISEENLKLKIEELNKDDSVNGIMLLLPLPKHIDERAVTNLIDADKDLDCLSEVSVGRFYKGEKCFMPCTPNSVITLLKAYNIEIEGKEVVIIGRSNIVGKPLFQMFLNENATVTVCHSRTKNLKEVCKRADILVVAIGRANFIDSSYVREGAVVIDVGTSEVNGKITGDVNFDDVYEKASLITPVPGGVGSLTTTLLLKNVCKELD

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Clostridium perfringens (strain 13 / Type A)

Length

277 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.337 kDa

Sequence

MDKILSGKTVAIDIKGQIKSYTEELKASGKSLKISSILVGDDGGSVYYQNFQEKLANNLGIDFEKIKLDESISEENLKLKIEELNKDDSVNGIMLLLPLPKHIDERAVTNLIDADKDLDCLSEVSVGRFYKGEKCFMPCTPNSVITLLKAYNIEIEGKEVVIIGRSNIVGKPLFQMFLNENATVTVCHSRTKNLKEVCKRADILVVAIGRANFIDSSYVREGAVVIDVGTSEVNGKITGDVNFDDVYDKASLITPVPGGVGSLTTTLLLKNVCKELD

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Clostridium perfringens (strain SM101 / Type A)

Length

277 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.351 kDa

Sequence

MDKILSGKTVAIDIKGQIKSYTEELKASGKSLKISSILVGDDGGSVYYQNFQEKLANNLGIDFEKIKLDESISEENLKLKIEELNKDDSVNGIMLLLPLPKHIDERVVTNLIDADKDLDCLSEVSVGRFYKGEKCFMPCTPNSVITLLKAYNIEIEGKEVVIIGRSNIVGKPLFQMFLNENATVTVCHSKTKNLKEVCKRADILVVAIGRANFIDSSYVREGAVVIDVGTSEVNGKITGDVNFDDVYEKASLITPVPGGVGSLTTTLLLKNVCKELD

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Kosmotoga olearia (strain ATCC BAA-1733 / DSM 21960 / TBF 19.5.1)

Length

277 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.02 kDa

Sequence

MGILLDGKPVAKMIYAEIKEWLGNLQEKPPKLVLFCSEPDDSTKTYMNSIVKRGGKLGISVEICHAGENPVEEIKKLNESRDVAGVMIMHPLKNVDEKLVVSALSLEKDVEGRTPGNLGGIMTGDESFAPPTAEAVMEILRFYDVSLSGKDVTIVGRSTTVGKPLSMLMLKKGIDATVTICHSRTKNLVEKIKRANVLVSAVGRAGFITKEMVGKDSIIIDVGINLYDGKIVGDVDFEQVEPEVAAITPVPGGVGIVTTAILFRHFMVSSRRMVGRR

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Acholeplasma laidlawii (strain PG-8A)

Length

277 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.601 kDa

Sequence

MLLDGRKTADILNEALRVKVQYLTKKPKLEIILIGNDEASKSYVKGKLNTASNLGMEVHINYLDEAIDQLSVEALIQKLNTDKGVHGILLQLPIPKHLDSDYLISLIDYKKDVDGFHTMNQGLLFQKKDGIRPATPLGIMMLLDFYNIPIEGKHVVIIGRSQIVGAPLSKMFLDRNATVTITHSKTKNLPSITKQADILVAAIGKPKFVTKDMVKVGAVVVDVGINRVDKKLVGDVDFEHVEPIASYITPVPKGVGPMTICALAHNLYALYLKQEKE

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Ruthia magnifica subsp. Calyptogena magnifica

Length

277 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30 kDa

Sequence

MNIIDGKQIAQNLRANIKLKVDALDRKPGLAVILVGDDEASEVYVRNKDNACKEVGFYSKKINKPINTTQAELLSEIECLNNSDKIDGILVQLPLPKHLDANLVIEAISPKKDIDGFHSENIGKLMQNKPFLRPCTSKGVMMIFEMIGVNLVGKNCVVVGASNIVGRPMACELLNAQATVTICNSKTKNLSNKLKQADIVVVAVGIAQMIQKDWIKPGSIVIDAGINRLDNNQLVGDVDFESVMQVASWITPVPGGVGPMTIAALLENTLIAYEGKI

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Exiguobacterium sibiricum (strain DSM 17290 / JCM 13490 / 255-15)

Length

277 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.936 kDa

Sequence

MAVVIDGKQVAQSYRLKLKEEVARLKEERIQPKLTVILIGEDPASQSYVRGKEKAAQEIGMDSDLIRLPEETKESELLHLIERLNADASVHGILVQLPLPKHIDESKVIFAIAPEKDVDGFHPVSVGKMMIGEPTFLPCTPNGILHLVKEMNVPIAGRHVVVVGRSQIVGKPVGMLFLNESATVTYCHSKTADLGAMTRQADILIVAVGVPKLITADMVKPEAVVIDVGVNRVDGKLVGDVEFEAVKEVASMITPVPGGVGPMTITMLLHNTIEAAK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)

Length

276 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.782 kDa

Sequence

MIIDGVKISETKMERLKNEIEKIKNTGINPKMKIILIGNDYGSVVYSKAKMRRGSKLGIDVDLDRYDSISREDLIKLLKRYSQSDDIHGIMIETPVPGINYYDVVNEIPFYKDVDGMTSYNLGNLYLKNEFIAPATARAVVDILDYINIKSGNVAIINRSPVVGRPLSMMLLNRDFTVTVCHSRTVNINEITRSSDIVVVAVGKPNFLDRSYVSDKNIIIDVGINYLNGKTCGDADYENIKDYVNAITPVPGGVGPVTATDIFENFINGLKYQIKG

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)

Length

276 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.622 kDa

Sequence

MKILRGEEIAEKKAENLHGIIERSGLEPSLKLIQIGDNEAASIYARAKIRRGKKIGIAVDLEKYDDISMKDLLKRIDDLAKDPQINGIMIENPLPKGFDYYEIVRNIPYYKDVDALSPYNQGLIALNREFLVPATPRAVIDIMDYYGYHENTVTIVNRSPVVGRPLSMMLLNRNYTVSVCHSKTKDIGSMTRSSKIVVVAVGRPGFLNREMVTPGSVVIDVGINYVNDKVVGDANFEDLSEYVEAITPVPGGVGPITATNILENVVKAAEFQKNNL

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Frankia sp. (strain EAN1pec)

Length

275 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

27.512 kDa

Sequence

MRLLDGRSMAADIGRSVVDDVERLATTGVTPTLAVVLPTADEAARSYVRVIERGAAKVGVGCAVHELTGDPDELTATVDRLAADPAVHGMIVQTPLPDGLTAADVGARIPVGKDVDGMNPLSLGRLALGLPAFAPATAAAVLEILNRAAVPLAGARACVIGRSSVVGKPAALLLLAEDATVTVCHSRTKDLATVAHDADIVVAAVGRPKMVGAGHVRPGAVVIDVGTNWTDAGLVGDVDADAVAPVAGALTPVPGGVGPVTTMLLLRNTVRAAGG

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Pseudothermotoga lettingae (strain ATCC BAA-301 / DSM 14385 / NBRC 107922 / TMO)

Length

273 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.423 kDa

Sequence

MIIDCRSISKEIDEETLKLLTICKTKPKLVSFTINPDSGTISYLKSQQKKARSLGIEYETRVLDSVDDLKSDILNASKDSSVHGIFVSHPLPAGINEMEIAKLVDPEKDIEGRNPLNMGYLIYGKEDFAPCTATAVVRILTSVTSVTGKQVVIIGRSTTVGQPAAIMLLRRDRSATVTVCHSKTRDIPSITKKADIIIVAVGKAGFLKKDMVKEEAVVIDVGINILDGKIAGDVEQSVQEIAYLTPVPGGVGLVTTSVLMNRVAKNASRGDSN

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Coprothermobacter proteolyticus (strain ATCC 35245 / DSM 5265 / BT)

Length

273 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.456 kDa

Sequence

MALIMKGKPVADAIYEELQPMTSLNLTLGIIKYKGSDAGGYLSGLSKAAQRLNVQLRVNEVEQFQELTQSVVVMGKDSQVHGILLLKPFPKEWNFRQASDLIPPEKDVDALHPVNLGKLAQGRGNLVPATPQAVLSILDFYNVLPLEGASALVIGRSEAVGLPAFLQLMQRNATVTVAHSRTKDLPSLSRQADLVVVAVGKPNFLTKDHVKEGAVVIDVGTNVLEDGKVVGDVDRENVEPLVRAITPVPGGVGSVTTACLFKNLFLCYQEQTR

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)

Length

273 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.457 kDa

Sequence

MSFDGKLKAQSILETYKNFDWSKCKLVIIQANDDDSSDSFIKQKLIACNTVGAKSELIKLSNQITQAELIEKIISLNHDVNVTGIILQLPVYPHLDKNSLLEAINPLKDVDGLTTNHLAEIKPCIVEAIITLKELFNLEFNNQKIVVVGLGITGGKPIYEFLKTSGYKVQACDKDTPNTFELIKSADIVFTAIGKSHFFQAKNFKKGVILFDIGVSRNKQNKLCGDINPEGIEKKARWWTKTPGGVGPFTVLAIIKNLWILHEKNKRCLQSSI

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Coprothermobacter proteolyticus (strain ATCC 35245 / DSM 5265 / BT)

Length

273 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.456 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)

Length

273 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.457 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Petrotoga mobilis (strain DSM 10674 / SJ95)

Length

273 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.051 kDa

Sequence

MLIEVDNIIDEIKAEISSLKEKVPYEPKLVSLVVEPDESTKSYLNSQKRNAKKFGINLEIVESNDLTNDLRKYNEDDDTDAIFIARPLKKGYTELDIAKYINPEKDVEGVSLHNIGSMFYEKELFVPCTAEAVVKIIEDTTDVRGKNIVILGRSTTVGKPAAIMLQRHGRDATVTVTHTKTKNLKEITKEADILVAAIGKANFVDSTFVKEGMIVIDVGINVVDGKIVGDVNKDVSEICQLTPVPGGVGSVTTAILMRNVFRAANNKKGDMQL

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Mycoplasma pulmonis (strain UAB CTIP)

Length

272 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.885 kDa

Sequence

MMKKLLSNELVQIKRAELKEKFSKLDQKVKFAIVLIGDNASSKIYVKKKIEFAQDIGVEAKLFHFEENVDFNLLKDAFKKIDKEYDGIILQLPVLHFDVNELLLMIDKNKDLDGLNPENEKAFYENRECIIPATARAIWTFLKFHKISVENKKVFVVGQSRLVGKPISQFLKNNNAIVRVFDKSTGLKGTEEADILIVATGVAQLIKAENIKENSILIDVGFSKINNKIYGDLDIESIKEKALKYTPPIGAIGPVTVLSLFENLYEIILKKK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Mycoplasma pulmonis (strain UAB CTIP)

Length

272 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.885 kDa

Sequence

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Fervidobacterium nodosum (strain ATCC 35602 / DSM 5306 / Rt17-B1)

Length

272 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.472 kDa

Sequence

MFINIEPLYSSMVENIKERVSKLSKPPKLVAVTCQPDSSTLAYLRSQEKQAKRFGIDFAVYEAPKAMDLKILLPKLSADGSVNGIFLTHPLPSDISEYEAVSLISPDKDIEGRHPINLGNILYDKPVFPPCTAEAVLRIINYLTNPSGKKIAVIGRSVTVGKPLAMLLLQKGIDATVTICHSRTKDIAEITKNSDIVVVAIGKAKMFGKDYFKPGTIVIDVGINVEGDEIVGDVDPSVSEICELTPVPGGVGRITTLVLMEHTVKAAEMSLK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Thermosipho melanesiensis (strain DSM 12029 / CIP 104789 / BI429)

Length

271 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.642 kDa

Sequence

MIIDVKPLYEDIKVNLLKRIEKLKRTPKLVAVTFKPDPSTVSYLKSQEKAAKRFGLDYEIFEGNSPKGVLKILAELSRDNNVNGIFVTHPLSQVNEMEIFENLVPSKDIEGRHPYNLGMLAYGEEFFAPCTAEAVVRIMENEIGIPGKNVVIVGRSNTVGKPLAIMLLRRDRSATVTVCHTKTRNLSSITKGADVVVAAAGRPGLITVDMVEKDSIIIDVGINVTDEGIIGDVSKDVANFAKVTPVPGGVGKITTILLMEHLVKSAEKMNF

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)

Length

271 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.557 kDa

Sequence

MWIDCKTIARSIEERTKERVEKLGFTPKLVSVACTDDPSALSYLKSQRKKAEKLGIAFEIMNVSPEEIVSTLKKLGSDESVNGVFVARPFPLGLDEKEILSSVPVEKDVEGVNPANLGLLLYDEEIFPPCTAEAAVRILERETNLSGKRVTVVGRSVTVGKPLALMLLKKGRDATVTVCHSRTVNLEEITKNSDIVVVAVGRAHFLKKNMVKEGAIVIDVGINYVDGKLQGDVDPSVEEIARVTPVPGGVGQVTTALLFEHVVRAAERQRK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Thermotoga petrophila (strain RKU-1 / ATCC BAA-488 / DSM 13995)

Length

271 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.645 kDa

Sequence

MWIDCRTIARSIEERTKERVEKLGFTPKLVSVACTDDPSTLSYLKSQRKKAEKLGIAFEILNVSPEEIVSTLKKLGSDESVNGVFVARPFPPSFDEKEILSSVPVEKDVEGVNPANLGLLLYDEEIFPPCTAEAAVRILERETNLSGKRVTVVGRSVTVGKPLALMLLKKGRDATVTVCHSRTVNLEEITKNSDIVVVAVGRAHFLKKNMVKEGAIVIDVGINYVDGKLQGDVDPSVEEIARVTPVPGGVGQVTTALLFEHVVRAAERQRK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Thermotoga sp. (strain RQ2)

Length

271 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.615 kDa

Sequence

MWIDCRTIARSIEERTKERVEKLGFTPKLVSVACTDDPSALSYLKSQRKKAEKLGIAFEILNVSPEEIVSTLKKLGSDESVNGVFVARPFPPSFDEKEILSSVPVEKDVEGVNPANLGLLLYDEEIFPPCTAEAAVRILERETNLSGKRVTVVGRSVTVGKPLALMLLKKGRDATVTVCHSRTVNLEEITKNSDIVVVAVGRAHFLKKNMVKEGAIVIDVGINYVDGKLQGDVDPSVEEIARVTPVPGGVGQVTTALLFEHVVRAAERQRK

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Thermosipho africanus (strain TCF52B)

Length

271 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

29.955 kDa

Sequence

MLIDVKPLYSEIKNLIMDRMSKLKKVPKLVAVTYKPDPSTISYLKSQEKAAKRFGLDYEIFEASNSIEVLEKLRKLSEDKSVNGIFVTHPLPELDEMLVFENLSPEKDIEGRHPYNLGMLMYGNEFFAPCTAEAVVKILENVTEITGKNVVIIGRSTTVGKPLATMLLRRDRSATVTVCHTKTRNLPEITRNADIIVAAAGKARLVTKEMVKSDSIVIDVGINVVDGKIVGDVKEDVSEIAKVTPVPGGVGRITTALLMEHVVKSAEKMNF

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Mycoplasma pneumoniae (strain ATCC 29342 / M129)

Length

269 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.204 kDa

Sequence

MSFDGKQLAHEILLTYKNRDWSQVKLVILQTNNDVSSDAFIRQKMNACNTLGAQSELIKYHESVTEKELLEKIQQLNTDPEVTGIILQLPVYPHLKQNKLLKAIDPYKDVDYLTGNCPLPIRSCVVEAVLILKEHFHHDFTNKQIVVVGLGVTGGGPIFHYLKETGHQVVGCDKHTPNTMELIKTADVVITAIGKPHFFKTTNFKPGVILYDVGVSRNVLNKLCGDIDPNGIEKVAKWWSPTPGGVGPFTVLAIMKNLWVLYEAHQRRI

Protein

Bifunctional protein FolD: folD

Gene

folD

Protein

Bifunctional protein FolD

Organism

Mycoplasma pneumoniae (strain ATCC 29342 / M129)

Length

269 amino acids

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Similarity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Mass

30.204 kDa

Sequence

Protein

Bifunctional protein FolD: folD