Function
Coordinates cell shape changes during formation of the ventral furrow and invagination of the posterior midgut primordium, by inducing apical constriction of cells in spatially and temporally defined manners. Could function as a secreted signal to initiate apical constriction by acting as a ligand for an unidentified G protein-coupled receptor, which in turn activates the G protein alpha subunit encoded by concertina, in neighboring cells. Such an intracellular pathway would ultimately induce contraction of the apical actin-myosin network. In the ventral furrow, fog appears to ensure that all the cells initiate constriction within several minutes of each other. In the posterior midgut invagination, fog appears to direct the ordered progression of constriction initiations out from a central region and also to delimit the peripheral extent of this spreading.
Sequence
MSPPNCLLAVLALTVFIGANNALPITSRPIEGNVQRMVWEDWVNLDPEQRNLTKEKKITAKSIFTLPFRHCPQGHTLFNQLCIPQSNIDPTDLVKQELILAGGSNGSPPPPPIGDYDYGDDEESEEIVYDLSVIPTAMQDGLPPSVGTGDQALPSEDAPLKFNIFEKKFPTGTGEHEEMPLPPDMAAATYAKNISTTPETSTSITPTSTTTFAVPSVPSGEASNRIPGGVDLLAAPSDAFSTSTTLSMPTSNTTTTSNKDIGQVESIVLPADQEHDGLVHLVTSSLSDNDSDDSSTTLNGFNAEADLAQLLKVDAFWPVYDGSIELLPPLFSHRKVAPPLSADQDVKTKHAVDAAEKVGAELEEEVGEEEVTATDILPSEEDEYTTETATTTGDTTVAEASMDTSTATSTSGQSSPHPPEEPEIDERENRLVLIKSKVQPVQLTTTTSATATTAADVANSSSSTDRFHYQHFVEDESSTTTATPEPSSSTPGDPIEQSDMPASDNDNLMTNTIGGRGDDDDDGGHKATSEIHVQQELRLINELVKGKQRQQHQPQKQQLEPTSTEITSALTSTSTEDATTTTTTTTAYTNWSKVMPQLGQSTSETAATTETVATSGQVNEISLTATSASTEVKHFSITNRSYRNSKIIREDRLTVEPEGIVESAASTESAGTAATTPNSSSNPDGYTPLWWLPSIGWRLDRHLDGNGEDQSLLLRFFSTFRGSNTAATTR