Function
Catalyzes the reduction of NADP(+) with F420H(2) via hydride transfer, and the reverse reaction, i.e. the reduction of F420 with NADPH. In M.organophilum, an alcohol-fermenting methanogen containing an NADP-dependent alcohol dehydrogenase, is probably involved in the regeneration of F420H(2) required for CO(2) reduction to methane. Thus, during growth on alcohol and CO(2), the F420-dependent NADP reductase probably has the function of coupling the NADP-dependent oxidation of the alcohol to the aldehyde with the F420-dependent reduction of CO(2) to methane.