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fno

Gene
fno
Protein
F420-dependent NADP reductase
Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)
Length
232 amino acids
Function
Catalyzes the reduction of NADP(+) with F420H(2) via hydride transfer, and likely the reverse reaction, i.e. the reduction of F420 with NADPH. Probably functions in the regeneration of NADPH required in biosynthetic reactions. Is specific for reduced F420 as electron donor for the reduction of NADP; neither reduced FAD nor FMN can act as electron donor. The enzyme is also specific for NADP; NAD is not utilized as substrate.
Similarity
Belongs to the F420-dependent NADP reductase family.
Mass
24.539 kDa
Sequence
MIKVMVMKIAVIGGTGDQGLGLALRFAVAGEEVIIGSRDAEKASKAASKVLEIAGRDDISVEGATNPDAAASADVVVLTVPLQAQMVTLASIRDQVRDKVLIDATVPIDSCIGGSAVRYIDLWEGSAAERAARFLREQGTRVAAAFNNISASALLEVSEPVDCDCLVASDHRDALEVAAELAEKIDGVRAIECGGLENARIIEKITPLLINLNIRNRVRNAGIRITNLPEQE

Gene
fno
Protein
F420-dependent NADP reductase
Organism
Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg)
Length
224 amino acids
Function
Catalyzes the reduction of NADP(+) with F420H(2) via hydride transfer, and the reverse reaction, i.e. the reduction of F420 with NADPH. Probably functions in the regeneration of NADPH required in biosynthetic reactions.
Similarity
Belongs to the F420-dependent NADP reductase family.
Mass
23.448 kDa
Sequence
MKIAVLGGTGDQGLGLALRLALAGEEVIIGSRDAEKAVSAAQKVLEIAERDDLKVKGATNAEAAEEAEVAILTVPLQAQMATLGSVKEAIKGKVLIDATVPIDSCLGGSAVRYIDLWDGSAAERAARFLEDQGTRVAAAFNNISASALLDITGPVDCDCLIASDHRDALDLASELAEKIDGVRAIDCGGLENARVIEKITPLLINLNIKNRIRNAGIRITNLPE

Gene
fno
Protein
F420-dependent NADP reductase
Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
Length
223 amino acids
Function
Catalyzes the reduction of NADP(+) with F420H(2) via hydride transfer, and the reverse reaction, i.e. the reduction of F420 with NADPH. Probably functions in the regeneration of NADPH required in biosynthetic reactions.
Similarity
Belongs to the F420-dependent NADP reductase family.
Mass
24.068 kDa
Sequence
MKIAILGGTGDQGFGLALRLAKNNKIIIGSRKKEKAEEAAKKAKEILKQRGIEADIIGLENKDAAKEGDVVILSLPYEYTLSTIKQLKEELKGKIVVSIGVPLATAIGDKPTRLLFPPDGSVAEMVQNVLKESKVVSAFQNVCHAVLEDLDNPVDCDILVCGNDEEAKKVVIDLANQIDGVRAIDCGNLEKSRIIEAITPLLIGLNIKYKSKGTGIRITNLEI

Gene
fno
Protein
F420-dependent NADP reductase
Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Length
212 amino acids
Function
Catalyzes the reversible reduction of NADP(+) by F420H(2). In this reaction the proS hydrogen at C5 of F420 is transferred into the proS position at C4 of NADPH.
Similarity
Belongs to the F420-dependent NADP reductase family.
Mass
22.865 kDa
Sequence
MRVALLGGTGNLGKGLALRLATLGHEIVVGSRREEKAEAKAAEYRRIAGDASITGMKNEDAAEACDIAVLTIPWEHAIDTARDLKNILREKIVVSPLVPVSRGAKGFTYSSERSAAEIVAEVLESEKVVSALHTIPAARFANLDEKFDWDVPVCGDDDESKKVVMSLISEIDGLRPLDAGPLSNSRLVESLTPLILNIMRFNGMGELGIKFL

Gene
fno
Protein
F420-dependent NADP reductase
Organism
Methanogenium organophilum
Length
36 amino acids
Function
Catalyzes the reduction of NADP(+) with F420H(2) via hydride transfer, and the reverse reaction, i.e. the reduction of F420 with NADPH. In M.organophilum, an alcohol-fermenting methanogen containing an NADP-dependent alcohol dehydrogenase, is probably involved in the regeneration of F420H(2) required for CO(2) reduction to methane. Thus, during growth on alcohol and CO(2), the F420-dependent NADP reductase probably has the function of coupling the NADP-dependent oxidation of the alcohol to the aldehyde with the F420-dependent reduction of CO(2) to methane.
Similarity
Belongs to the F420-dependent NADP reductase family.
Mass
3.775 kDa
Fragment
single
Sequence
MKVGIMGGTGNIGEGLARRIXIGGKYDVMIKGRDKA