Protein
Major fimbrium tip subunit FimE
Organism
Porphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / CIP 103683 / JCM 12257 / NCTC 11834 / 2561)
Function
Probably a component of the fimbrium tip; required for incorporation of FimC and FimD into fimbriae (PubMed:17526848, PubMed:19506009). These long, filamentous pili are attached to the cell surface; they mediate biofilm formation, adhesion onto host cells and onto other bacteria that are part of the oral microbiome (PubMed:17526848, PubMed:19506009). They play an important role in invasion of periodontal tissues and are major virulence factors (Probable). FimC, FimD and FimE contribute to interaction with host CXCR4 and thereby down-regulate the TLR2-mediated host immune response (PubMed:19506009).
Similarity
Belongs to the FimE family.
Sequence
MKSKSIIAQLLYVLIAFMAVSCVADKSEPCPSGEPTRVSGSIVSLEHHGLRGASADKENSVERLELWVFDEDGHFLERAVADLSGSTFTAKIIPSEVERRIHFIANYELADPSVWVGRSEREMLPSISVADDLETIRMWARISYPSIAPNQNLGQIQLLRNMAKFSLSVTPPAESKLYDASYALYNSWNKGTLAPFDPNTGSFPQGQITEPAGVVFANPTSEAAFKEADGAHFFYGFERDQSNIGTGAGITCLILKARYNLPNADYTYYKLDFVDTNKVRYNITRNHFYKMILKKAKAPGRPTLQEALDGAAANNIFLSAEVQALPAFSDGSGMLTVDHTYMVFVQGEPSGTFQATYIPQGQNNPDYSKLTVSVSTPTGQQAAVTSAQHEGNGKIKLTLAQQENLTKRSDVVIGVQGNPDLKRSVTVLVREKYQYVFFKANTSSAENNQVTTQISAGQGNELLISAKLPDVLNAALLPITFKVYTEHFYPKTGGMILGIEGGKTLYKYVLTTMPQNKELQFRFKSNKVNSAENIAVKMDYFHDQTIHVTN