fimC

Outer membrane usher protein FimC

873 amino acids

Probable porin-like protein necessary for the assembly of a pilin-type protein.

Belongs to the fimbrial export usher family.

93.369 kDa

MKQIPLILAMSLAFAAAAKGESAPDMQAAVNFDSAMLWGGANGADLSRFNYSNALRPGNYIVDIYANNYPLIRQQVRFVAAQTSGQGLKTAPAVACFTYGQLEAMQVRLRALDPALVADLKSSGRCEVLGKLFPDSRESFDFGENRLEVSIPQAYTINRFRRDISPDEWDSGITAFRLGYQYNYADYIGGLRAGRRLDLNLYSGFNFKGWYLRNSSTLGWGQGRFTRRSQRTSLQTDIPSWRARLVFGDVFSSGEYFAPYSMRGMLVGSDTAMLPYSERLYRPTIRGVARTRANVKVYQAGVLVFQDAVPPGPFAIDDYSPASYGGDLRVVVTEANGAVQTFTVPYASAVRLILPGQTQWSFSAGRYRNYRNDGQDRPWVTQLTGRHGVADGVNLYGGLLIAQAYQAGLAGLSWNTPWGAMAADATLSRSQLSTTGNANGSSLRFSYSKTLSGTNTAIRLATLRYSSSGFWNFADAVNAGPVETNGRNGRFGLYSLLGRERPRGDFSVTLSQPLGGYGSLYVSALRRTYWGSSRVDQQTQLGYSTQVGRVGVNLDVSRTENRRSTEHQVMLNLSIPLYGATSSGVVTGSLARTGSAPVQQSVNYSGMSGERDQYTYGLGVQRAGTSAQYALNGSWSGTYGEVSGQLTHGRSYSQYQINGSGGLVAHAGGVTFGQYQAGTIGLIQAEAAAGAKVVNTRNAAVDRSGYGLVSLTPYSLNEVELSPQDLPLDVQLESTVEQVIPRAGAVVALRFPTRHDVAAMLVAEPGSEGALVFGTEVRDGAGKVVGVAGQGASALVRGVSASGTLEVTRADGSICRATYDLKSAGQAVHGLPRIALACAPQGGGERGARAAGQAVAQPSAISISGKDHEPDIR

fimC

Major fimbrium subunit FimC

453 amino acids

Minor component of fimbriae (PubMed:17526848). These long, filamentous pili are attached to the cell surface; they mediate biofilm formation, adhesion onto host cells and onto other bacteria that are part of the oral microbiome (PubMed:17526848, PubMed:19506009). They play an important role in invasion of periodontal tissues and are major virulence factors (Probable). FimC, FimD and FimE contribute to interaction with host CXCR4 and thereby down-regulate the TLR2-mediated host immune response (PubMed:19506009).

Belongs to the bacteroidetes fimbrillin superfamily. FimA/Mfa1 family.

50.159 kDa

MKMKYFHHPSGLLPRLLLLLLLTMGAVACTKEDNPDQPTSDEVATVKMSLDDVEMRGGDLYSGEDLIKKVRIFVFREGLNGLWVLDKQKLFASGQSDFQNPFTISAHAGPRQIYVIANEPDALTTKLDKILFKKELEDMQAPDVNEPIVRPFTMTGMATATLNPQGTVQANISLNRIAAKITLDIKQVTPGSDVIKITKVQILRNAKNSRLLEGTNKPTGYWNWANACDLPLTNNGSAQSIIQASAPLYVYENIGSDSDSSGRATQLVVEALYNGIKTRYYAYVNDKTTTANHHYSIRRNHHYKLDGTITKMGEFSSLLLTTTVLPWTVENLDYGFLVPYVAEINPHAVITQDNVVTFENSLSFTVRIKGRDGSRWKATLDNGLEFGFDSGSAIDGAADGTTVYTIKVKALKPNGIGIQRRTNLFFTVDGKKVILDKNINPQPTDIKIIQQGL

fimC

Major fimbrium subunit FimC

453 amino acids

Minor component of fimbriae. These long, filamentous pili are attached to the cell surface; they mediate biofilm formation, adhesion onto host cells and onto other bacteria that are part of the oral microbiome. They play an important role in invasion of periodontal tissues and are major virulence factors. FimC, FimD and FimE contribute to interaction with host CXCR4 and thereby down-regulate the TLR2-mediated host immune response.

Belongs to the bacteroidetes fimbrillin superfamily. FimA/Mfa1 family.

50.159 kDa

MKMKYFHHPSGLLPRLLLLLLLTMGAVACTKEDNPDQPTSDEVATVKMSLDDVEMRGGDLYSGEDLIKKVRIFVFREGLNGLWVLDKQKLFASGQSDFQNPFTISAHAGPRQIYVIANEPDALTTKLDKILFKKELEDMQAPDVNEPIVRPFTMTGMATATLNPQGTVQANISLNRIAAKITLDIKQVTPGSDVIKITKVQILRNAKNSRLLEGTNKPTGYWNWANACDLPLTNNGSAQSIIQASAPLYVYENIGSDSDSSGRATQLVVEALYNGIKTRYYAYVNDKTTTANHHYSIRRNHHYKLDGTITKMGEFSSLLLTTTVLPWTVENLDYGFLVPYVAEINPHAVITQDNVVTFENSLSFTVRIKGRDGSRWKATLDNGLEFGFDSGSAIDGAADGTTVYTIKVKALKPNGIGIQRRTNLFFTVDGKKVILDKNINPQPTDIKIIQQGL

fimC

Probable fimbrial assembly protein FimC, serogroup D

244 amino acids

28.027 kDa

MLKNIDFSAFQLKVIAIMAMSLDHFALLFLSDGIGRYECLRFIGRLTLPLMCFFLVEGFFHSRNHQKYLGRLLFFAFIAQPFYSWMIAFDQINALDLRFFLQTGNVLFTLALALLALMIRASRLSVLLKISLIFAISFAALYCDWGIYPVIFTLILAHYYPDRKAQTIAYLLAAMGLLLLADRQIFAVMPSLVLHIMPAGILLPPLFWHFYHGKKGARFGGRYAFYLFYPAHMALLCSAKMFLQ

fimC

Probable fimbrial assembly protein FimC, serogroup H1

244 amino acids

27.961 kDa

MSRNIDFSAFQLKVIAIIAMSLDHSALLFLSDGSWRYECLRFVGRLTLPLMCFFLVEGFFHSRNHQKYLGRLLFFGVIAQPFYSWMIAFDQIDSADLRFFLQTGNVLFTLALALLALMIRASRLSVPLKITLIFALSFAALYCDWGIYPVIFTLVLAHYYPERKAQTIAYLLAAMGLLLLADRQIFAVMPSLVLHIMPAGILLPPLFWHFYHGKKGARFGGRYAFYLFYPVHIALLCSAKMFLQ

fimC

Chaperone protein FimC

241 amino acids

Required for the biogenesis of type 1 fimbriae. Binds and interact with FimH (By similarity).

Belongs to the periplasmic pilus chaperone family.

26.597 kDa

MSNKNVNVRKSQEITFCLLAGILMFMAMVVAGRAEAGVALGATRVIYPAGQKQVQLAVTNNDENSTYLIQSWVENADGVKDGRFIVTPPLFAMKGKKENTLRILDATNNQLPQDRESLFWMNVKAIPSMDKSKLTENTLQLAIISRIKLYYRPAKLALPPDQAAEKLRFRRSANSLTLINPTPYYLTVTELNAGTRVLENALVPPMGESAVKLPSDAGSNITYRTINDYGALTPKMTGVME

fimC

Chaperone protein FimC

241 amino acids

Required for the biogenesis of type 1 fimbriae. Binds and interact with FimH.

Belongs to the periplasmic pilus chaperone family.

26.689 kDa

MSNKNVNVRKSQEITFCLLAGILMFMAMMVAGRAEAGVALGATRVIYPAGQKQEQLAVTNNDENSTYLIQSWVENADGVKDGRFIVTPPLFAMKGKKENTLRILDATNNQLPQDRESLFWMNVKAIPSMDKSKLTENTLQLAIISRIKLYYRPAKLALPPDQAAEKLRFRRSANSLTLINPTPYYLTVTELNAGTRVLENALVPPMGESTVKLPSDAGSNITYRTINDYGALTPKMTGVME

fimC

Chaperone protein FimC

230 amino acids

Required for the biogenesis of type 1 fimbriae. Binds and interact with FimH.

Belongs to the periplasmic pilus chaperone family.

24.868 kDa

MLNSIKVGFIVLLTLFTSLNVQAAGGIALGATRVIYPSAAKQTSLAISNSDTQERYLVNSWIENNAGQKEKTFIVTPPLFVSEPKSENTLRIIYAGQPLPGDRESLFWMNVKAIPSVDKSHIEGKNVLQLAILSRIKLFVRPANLPQTPEDAPTLLKFSRVGNHLKITNPSAYYLTLVNISVGAKKIDNVMIAPKSDMQIPLPTGAQGNVTFQSVNDYGALTSATTASLG