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ffh

Gene
ffh
Protein
Signal recognition particle protein
Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Length
525 amino acids
Function
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
Similarity
Belongs to the GTP-binding SRP family. SRP54 subfamily.
Mass
55.002 kDa
Sequence
MFESLSDRLTAALQGLRGKGRLTDADIDATTREIRLALLEADVSLPVVRAFIHRIKERARGAEVSSALNPAQQVVKIVNEELISILGGETRELAFAKTPPTVVMLAGLQGSGKTTLAGKLAARLRGQGHTPLLVACDLQRPAAVNQLQVVGERAGVPVFAPHPGASPESGPGDPVAVAAAGLAEARAKHFDVVIVDTAGRLGIDEELMAQAAAIRDAINPDEVLFVLDAMIGQDAVTTAAAFGEGVGFTGVALTKLDGDARGGAALSVREVTGVPILFASTGEKLEDFDVFHPDRMASRILGMGDVLSLIEQAEQVFDAQQAEEAAAKIGAGELTLEDFLEQMLAVRKMGPIGNLLGMLPGAAQMKDALAEVDDKQLDRVQAIIRGMTPQERADPKIINASRRLRIANGSGVTVSEVNQLVERFFEARKMMSSMLGGMGIPGIGRKSATRKSKGAKGKSGKKSKKGTRGPTPPKVKSPFGVPGMPGLAGLPGGLPDLSQMPKGLDELPPGLADFDLSKLKFPGKK

Gene
ffh
Protein
Signal recognition particle protein
Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Length
525 amino acids
Function
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
Similarity
Belongs to the GTP-binding SRP family. SRP54 subfamily.
Mass
55.002 kDa
Sequence
MFESLSDRLTAALQGLRGKGRLTDADIDATTREIRLALLEADVSLPVVRAFIHRIKERARGAEVSSALNPAQQVVKIVNEELISILGGETRELAFAKTPPTVVMLAGLQGSGKTTLAGKLAARLRGQGHTPLLVACDLQRPAAVNQLQVVGERAGVPVFAPHPGASPESGPGDPVAVAAAGLAEARAKHFDVVIVDTAGRLGIDEELMAQAAAIRDAINPDEVLFVLDAMIGQDAVTTAAAFGEGVGFTGVALTKLDGDARGGAALSVREVTGVPILFASTGEKLEDFDVFHPDRMASRILGMGDVLSLIEQAEQVFDAQQAEEAAAKIGAGELTLEDFLEQMLAVRKMGPIGNLLGMLPGAAQMKDALAEVDDKQLDRVQAIIRGMTPQERADPKIINASRRLRIANGSGVTVSEVNQLVERFFEARKMMSSMLGGMGIPGIGRKSATRKSKGAKGKSGKKSKKGTRGPTPPKVKSPFGVPGMPGLAGLPGGLPDLSQMPKGLDELPPGLADFDLSKLKFPGKK

Gene
ffh
Protein
Signal recognition particle protein
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Length
525 amino acids
Function
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY (By similarity). Shows GTPase activity.
Similarity
Belongs to the GTP-binding SRP family. SRP54 subfamily.
Mass
55.002 kDa
Sequence
MFESLSDRLTAALQGLRGKGRLTDADIDATTREIRLALLEADVSLPVVRAFIHRIKERARGAEVSSALNPAQQVVKIVNEELISILGGETRELAFAKTPPTVVMLAGLQGSGKTTLAGKLAARLRGQGHTPLLVACDLQRPAAVNQLQVVGERAGVPVFAPHPGASPESGPGDPVAVAAAGLAEARAKHFDVVIVDTAGRLGIDEELMAQAAAIRDAINPDEVLFVLDAMIGQDAVTTAAAFGEGVGFTGVALTKLDGDARGGAALSVREVTGVPILFASTGEKLEDFDVFHPDRMASRILGMGDVLSLIEQAEQVFDAQQAEEAAAKIGAGELTLEDFLEQMLAVRKMGPIGNLLGMLPGAAQMKDALAEVDDKQLDRVQAIIRGMTPQERADPKIINASRRLRIANGSGVTVSEVNQLVERFFEARKMMSSMLGGMGIPGIGRKSATRKSKGAKGKSGKKSKKGTRGPTPPKVKSPFGVPGMPGLAGLPGGLPDLSQMPKGLDELPPGLADFDLSKLKFPGKK

Gene
ffh
Protein
Signal recognition particle protein
Organism
Mycobacterium leprae (strain TN)
Length
521 amino acids
Function
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
Similarity
Belongs to the GTP-binding SRP family. SRP54 subfamily.
Mass
55.112 kDa
Sequence
MFESLSNRLTGVIQGLRGKGRLTDADIEATTREIRLALFEADVSLPVVRAFVHRIKERARGTEVSAALNPAQQIVKIVNEELIGILGGETRQLAFAKTPPTVVMLAGLQGSGKTTLAGKLAVRLRRQGHTPLLVACDLQRPAAVNQLQVVGERAGVPVFAPHPGASPDSGPGDPVAVASAGLVEARAKHFDVVIVDTAGRLGIDDELMAQAGAIREAINPDEVLFVLDAMIGQDAVTTAAAFGAGVGFTGVVLTKLDGDARGGAALSVREVTGVPILFATTGEKLDDFDVFHPDRMASRILGMGDVLSLIEQAEQVFDAEQAEAAAAKIVAGELTLEDFLEQMLAVRKMGLIGNLLGMLPGAGQVKEVLEQVDDKQLDRLQAIIRGMTPQERADPKIINASRRLRIANGSGVTVSEVNQLVDRFFEARKMMSSVLGGMGIPGMGRKSATRKSKGGKGKKRARGPTSPKVRSPFGPARPGMPDMMNMPPSFPDLSQMPDGLNELPPGLAAFDLSKLKFPGKT

Gene
ffh
Protein
Signal recognition particle protein
Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Length
516 amino acids
Function
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
Similarity
Belongs to the GTP-binding SRP family. SRP54 subfamily.
Mass
57.071 kDa
Sequence
MAFESLTERLQGVFKNLRGKRKLSEKDVQEVTKEIRLALLEADVALPVVKEFIKRVRKRAVGHEVIDTLDPSQQIIKIVNEELTAVLGSETAEIEKSSKIPTIIMMVGLQGAGKTTFAGKLANKLVKEENARPLMIAADIYRPAAIDQLKTLGQQINVPVFDMGTEHSAVEIVSQGLAQAKENRNDYVLIDTAGRLQIDEKLMTELRDIKALANPNEILLVVDSMIGQEAANVAREFNQQLEVTGVILTKIDGDTRGGAALSVRQITGKPIKFTGTGEKITDIETFHPDRMSSRILGMGDLLTLIEKASQDYDEQKSAELAEKMRENSFDFNDFIEQLDQVQNMGSMEDILKMIPGMANNPALANVKVDEGEIARKRAIVSSMTPEERENPDLLTPSRRRRIASGSGNTFVNVNKFIKDFNQAKKMMQGVMSGDMNKVMKQMGINPNNMPKNMDSSALEGMMGQGGMPDMSELSGTNMDVSQMFGGGLKGKVGEFAMKQSMKKMAKRMKKAKKRKK

Gene
ffh
Protein
Signal recognition particle protein
Organism
Synechococcus elongatus (strain PCC 7942)
Length
485 amino acids
Function
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
Similarity
Belongs to the GTP-binding SRP family. SRP54 subfamily.
Mass
52.82 kDa
Sequence
MFDALAERLEQAWTKLRGQDKISESNVQEALKEVRRALLEADVNLGVVKEFIAQVQEKAVGTQVISGIRPDQQFIKVVYDELVQVMGETHVPLAQAAKAPTVILMAGLQGAGKTTATAKLALHLRKEGRSTLLVATDVYRPAAIDQLITLGKQIDVPVFELGSDANPVEIARQGVEKARQEGIDTVIVDTAGRLQIDTEMMEELAQVKEAIAPHEVLLVVDSMIGQEAASLTRSFHERIGITGAILTKLDGDSRGGAALSIRRVSGQPIKFVGLGEKVEALQPFHPERMASRILGMGDVLTLVEKAQEEIDLADVEKMQEKILAAKFDFTDFLKQMRLLKNMGSLAGFIKLIPGLGGKINDEQLRQGERQLKRVEAMINSMTPQERRDPDLLSNSPSRRHRIAKGCGQTEAEIRQIIQQFQQMRTMMQQMSQGGFPGMGGMGMPGFGGGMPGFGGGAPAPQPGFRGYGPPKKQKKGSKKKKGFGL

Gene
ffh
Protein
Signal recognition particle protein
Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Length
482 amino acids
Function
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
Similarity
Belongs to the GTP-binding SRP family. SRP54 subfamily.
Mass
52.145 kDa
Sequence
MFDALADRLEDAWKKLRGQDKISESNIKEALQEVRRALLAADVNLQVVKGFIKDVEQKALGADVISGVNPGQQFIKIVYDELVNLMGESNVPLAQAEQAPTVILMAGLQGTGKTTATAKLALYLRKQKRSALMVATDVYRPAAIDQLKTLGQQIDVPVFDLGSDANPVEIARQGVEKAKELGVDTVLIDTAGRLQIDPQMMAELAEIKQVVKPDDTLLVVDAMTGQEAANLTHTFHEQIGITGAILTKLDGDTRGGAALSVRQISGQPIKFVGVGEKVEALQPFYPDRLASRILNMGDVLTLVEKAQEAIDVGDVEKLQNKILEATFDFDDFIKQMRFMKNMGSLGGLLKMIPGMNKLSSGDIEKGEKELKRTEAMISSMTTEERKNPDLLAKSPSRRRRIAQGSGHSETDVSKLITNFTKMRTMMQQMGMGGMPGGMPGMGAMPGMGGGMFGGQPGPGFRGYRGGGGKPKKKKKKKGFGQL

Gene
ffh
Protein
Signal recognition particle protein
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Length
462 amino acids
Function
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
Similarity
Belongs to the GTP-binding SRP family. SRP54 subfamily.
Mass
50.843 kDa
Sequence
MFENLSDRLSKTLRNITGKGRLTEDNIKETLREVRMALLEADVALPVVREFIAKVKESALGEEVNKSLTPGQEFLKIVQRELEKAMGEANESLNLATQPPAVILMAGLQGAGKTTSVGKLAKFLRERHKKKVLVVSADVYRPAAIKQLETLAQSVGVDFFPSDVKQNPVDIAKSALADAKLKFYDVLIVDTAGRLHVDTEMMDEIKQVHAALNPIETLFTVDAMTGQDAANTAKAFNEALPLTGVILTKVDGDARGGAALSIRQITGKPIKFLGVGEKTEALEPFHPDRVASRILGMGDVLSLIEDLERSVDREKAEKMAQKFKKGDDFTLDDFREQLIEMKKMGGMMSMLEKLPGAKNLSEHVKNQVDDKMFVKMEAIINSMTLKERANPDIIKGSRRRRIALGSGTQVQDVNKLLKQFDEMQRMMKKMRKGGMAKMMRGMQGLMGGGLGGLGGLGGMFKR

Gene
ffh
Protein
Signal recognition particle protein
Organism
Aquifex aeolicus (strain VF5)
Length
454 amino acids
Function
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
Similarity
Belongs to the GTP-binding SRP family. SRP54 subfamily.
Mass
50.912 kDa
Sequence
MLELLTEKFSHALEKLTNARKITEKNINQTLREIRLALLEADVDYQVAKDFIKRIREKVVGKEVPKNLSPAEFVIKTVYEELVDILGGEKADLKKGTVLFVGLQGTGKTTTIGKIANLLKKGGHKVAVSSTDLRRPAAMLQLQRLAERVGVPYYEFEEGLGAVEIARRAVKRAKEESVDYLLLDTAGRLHVDEELMKELQEIKEVTNPSEILYVADAMQGQTALETAKTFHERLGLTGVVITKMDGDARGGLALSVKEVLGVPIKFIGVGEKIEDIEPFYPDRIAQRILGLGDIQSLVEKAQEVITEDKAQVMATKVMTGEFDLEDLREMLRMIQQMGPLDKLLSMIPGVAPQLKHLKVDEKQFKKIEAIINSMTPEERRNPKIINMSRKKRIARGSGTTVSDVNKLLKRYEEMKKMMRKLQKAGGMPAIPKMPKMPRFPSEASSFNLFLFLST

Gene
ffh
Protein
Signal recognition particle protein
Organism
Escherichia coli O157:H7
Length
453 amino acids
Function
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
Similarity
Belongs to the GTP-binding SRP family. SRP54 subfamily.
Mass
49.787 kDa
Sequence
MFDNLTDRLSRTLRNISGRGRLTEDNVKDTLREVRMALLEADVALPVVREFINRVKEKAVGHEVNKSLTPGQEFVKIVRNELVAAMGEENQTLNLAAQPPAVVLMAGLQGAGKTTSVGKLGKFLREKHKKKVLVVSADVYRPAAIKQLETLAEQVGVDFFPSDVGQKPVDIVNAALKEAKLKFYDVLLVDTAGRLHVDEAMMDEIKQVHASINPVETLFVVDAMTGQDAANTAKAFNEALPLTGVVLTKVDGDARGGAALSIRHITGKPIKFLGVGEKTEALEPFHPDRIASRILGMGDVLSLIEDIESKVDRAQAEKLASKLKKGDGFDLNDFLEQLRQMKNMGGMASLMGKLPGMGQIPDNVKSQMDDKVLVRMEAIINSMTMKERAKPEIIKGSRKRRIAAGCGMQVQDVNRLLKQFDDMQRMMKKMKKGGMAKMMRSMKGMMPPGFPGR

Gene
ffh
Protein
Signal recognition particle protein
Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Length
453 amino acids
Function
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
Similarity
Belongs to the GTP-binding SRP family. SRP54 subfamily.
Mass
49.787 kDa
Sequence
MFDNLTDRLSRTLRNISGRGRLTEDNVKDTLREVRMALLEADVALPVVREFINRVKEKAVGHEVNKSLTPGQEFVKIVRNELVAAMGEENQTLNLAAQPPAVVLMAGLQGAGKTTSVGKLGKFLREKHKKKVLVVSADVYRPAAIKQLETLAEQVGVDFFPSDVGQKPVDIVNAALKEAKLKFYDVLLVDTAGRLHVDEAMMDEIKQVHASINPVETLFVVDAMTGQDAANTAKAFNEALPLTGVVLTKVDGDARGGAALSIRHITGKPIKFLGVGEKTEALEPFHPDRIASRILGMGDVLSLIEDIESKVDRAQAEKLASKLKKGDGFDLNDFLEQLRQMKNMGGMASLMGKLPGMGQIPDNVKSQMDDKVLVRMEAIINSMTMKERAKPEIIKGSRKRRIAAGCGMQVQDVNRLLKQFDDMQRMMKKMKKGGMAKMMRSMKGMMPPGFPGR

Gene
ffh
Protein
Signal recognition particle protein
Organism
Escherichia coli (strain K12)
Length
453 amino acids
Function
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
Similarity
Belongs to the GTP-binding SRP family. SRP54 subfamily.
Mass
49.787 kDa
Sequence
MFDNLTDRLSRTLRNISGRGRLTEDNVKDTLREVRMALLEADVALPVVREFINRVKEKAVGHEVNKSLTPGQEFVKIVRNELVAAMGEENQTLNLAAQPPAVVLMAGLQGAGKTTSVGKLGKFLREKHKKKVLVVSADVYRPAAIKQLETLAEQVGVDFFPSDVGQKPVDIVNAALKEAKLKFYDVLLVDTAGRLHVDEAMMDEIKQVHASINPVETLFVVDAMTGQDAANTAKAFNEALPLTGVVLTKVDGDARGGAALSIRHITGKPIKFLGVGEKTEALEPFHPDRIASRILGMGDVLSLIEDIESKVDRAQAEKLASKLKKGDGFDLNDFLEQLRQMKNMGGMASLMGKLPGMGQIPDNVKSQMDDKVLVRMEAIINSMTMKERAKPEIIKGSRKRRIAAGCGMQVQDVNRLLKQFDDMQRMMKKMKKGGMAKMMRSMKGMMPPGFPGR

Gene
ffh
Protein
Signal recognition particle protein
Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)
Length
451 amino acids
Function
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
Similarity
Belongs to the GTP-binding SRP family. SRP54 subfamily.
Mass
51.2 kDa
Sequence
MFNNLTQRLSDSLKKILNKGRLTEENIKETIREVRKALLEADVALSVIKKFIENVKKKSIGHEINKSLTPGQEFIKIVKHELIFAMGEKNHSLNFSIEPPAVILVVGLQGSGKTTSLAKLGKWIKNKYKKKILITSTDTYRAAAIEQLKILSDQIEIDFFESDKHHTPIEITKNAIKYAKLKLYDVLLIDTAGRLHIDKKMMNEIQQIQVISKAIETLLIVDSMMGQDAINMAKIFNNDLLISGIILTKTDGDSRSGIALSMRYITGKPIKFIGTGEKIISLEPFHPERIADRILGMNDIMSLIEDIEEKVDQSQIQKLTKKLKKGHDFNLNDFLTQIKQMKKIGGLNYFANKFSINHQLSNNISLLNTDKNTLKKIEAMICSMTPKERIKPIIIKGSRKRRIALGSGTQIQDVNKLLKNFDDIRRIMKKIKTDGIAKVIRGIKNMLPKKF

Gene
ffh
Protein
Signal recognition particle protein
Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Length
450 amino acids
Function
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
Similarity
Belongs to the GTP-binding SRP family. SRP54 subfamily.
Mass
51.017 kDa
Sequence
MFNNLTERLSQSLRKIINKGRLTEENIKDTIREVRKALLEADVTLSVIKKFIQNVSKKAIGHEINKSLTPGQEFIKIVKNELILSMGEKNHDLNLSIQPPAIILVVGLQGVGKTTTLVKLAKWIKEKYKKKILTVSTDIYRAAAIKQLQILSDQVKIDFYLSDTTQTPINITKEAIEHAKLKLYDLLLIDTAGRLHINTEMMNEINTIQNISKPIETLLIVDSMMGQDAINIAKKFSASLSISGIVITKTDSDARSGVALSIRHITGKPIKFIGTGEKLHQLEPFHPERIADRILGMNQVISLIKDIEEKVNQSQVKNLTKKFRKGDDFNLNDFLIQLKEMKNMGNLNYFIEKFSKNKILSNNPLLGENKNTLNRIEAIIYSMTHKERMHPIIIKGSRKRRIALGSGTKIQDVNKLLKNFDNIKKIMKKIKKGGIGKMIRNISNILPKNF

Gene
ffh
Protein
Signal recognition particle protein
Organism
Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Length
450 amino acids
Function
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
Similarity
Belongs to the GTP-binding SRP family. SRP54 subfamily.
Mass
51.069 kDa
Sequence
MFNNLTQRFLKIIKKISNKGRLTEKNIKETLREIRIALLEADVALPVVKNFIPSIQKSVIGNQVNKSLTPGQELIKIVKKELTLILGKENHSLNLSVTPPAIILMIGLQGSGKTTTTAKLGQLIRTKYKKKVIVTSIDIYRLAAIKQLKMLSKQAKISFFPSNNTQSPKDIVQHAIQHAKLKFYDVLLIDTAGRLQIDKKMMNELLDVYNISHPIETFFVADAMFGQDSINVINEFNKYLPVSSFIITKTDSDTRAGIILSIKYLTKKPIKFIGTGEKLEELELFYPDRIASRILGMGDMLSLIENIENKIDKKHIKKFSNTIKKYNTFNFNDMLLHINQIKKIGGVNSILGKLPKTQTIFNSFQNNIDENILLKMKTIINSMTISERHQPELIKGSRKRRISLGSGIPIPEINQLLKQFNNIKKIMKTIKKGGVTKIMQGINNIIKNKF

Gene
ffh
Protein
Signal recognition particle protein
Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Length
450 amino acids
Function
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
Similarity
Belongs to the GTP-binding SRP family. SRP54 subfamily.
Mass
50.141 kDa
Sequence
MFKSMISSIVMRSMQKKINAQTISETDVQAVLKEIRIALLDADVNLLVVKNFIKAIREQTVGQTVEPGQDLQKWLLKVIKQELINILSQPNQEITSKRPLKVMVVGLQGSGKTTTCGKLAVWLKKQFQQKAMLVALDIYRPAAIDQLATLAEQTESVFFAKGTQAPDQTTKEAVKTFKESGCQAIICDTAGRLQTNQELMDELVAIKNELHPDEILMVVDGLSGQEIINVAKEFHNRLKLTGFIITKLDSDARAGAALSLTSLLEVPIKLMGTSEKLTGLEQFHPERIASRILGLGDVMTLVEKAEEVFDKQSLTKTVSKMFLGKMDLEDLLLYMEQMNQMGSVSSIVKMLPGNLTVSDDHVESIEAKVKLWKVLINSMTREERRHPKLINRDPSRKQRIIKGSGRKMDELNKLMKEWSKLQTKTAEMGRMLKGGKNPFSGFGGLGGLGF

Gene
ffh
Protein
Signal recognition particle protein
Organism
Rickettsia bellii (strain RML369-C)
Length
449 amino acids
Function
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
Similarity
Belongs to the GTP-binding SRP family. SRP54 subfamily.
Mass
49.392 kDa
Sequence
MFKTLTQNLMKIFDRLVSSGLLTEEQIDAALRDIRVALLESDVALPVIKNFVAEVKQKALGQEVIKSVSPGQMIIKIIHEEMINILSSSEDEIKLNLNAKPPVNLLMVGLQGSGKTTASGKLALCLKNQNKKVLLVSLDTYRPAAQEQLEILANSVKINSLPIVKGEKPLDIVKRAMAEAKLSAYDIVIYDTAGRTQIDQEMMNEAIAIKKIVEPTETLLVIDSMTGQDAVVTASSFNEQLEISGLILSRIDGDSKGGAALSVKYITQRPIKFLSSGEKLTDLEEFDAKRIASRILDMGDIISFVEKAASIVDREQAEKTAAKLKKGKFDLNDYLQQMKSIKKIGGFGSILSMLPGSGKIMDQIDQSKLNSKIIEHQEAIILSMTPKERRNPDIINASRRKRIALGAGTTVQKVNILLKQFKQISDMMKKASNMNPKNLLRSGLGKLFS

Gene
ffh
Protein
Signal recognition particle protein
Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Length
449 amino acids
Function
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
Similarity
Belongs to the GTP-binding SRP family. SRP54 subfamily.
Mass
49.252 kDa
Sequence
MFKTLTQNLTKIFDKLVSSGILTEAQIDAAMRDIRVALLESDVALPVIKDFIAEVKQKALGQEVIKSVSPGQMIIKIIHEEMINLLASSKSETKLNLNSKPPVNFLMVGLQGSGKTTASSKLALRLRNQNKKVLLVSLDTYRPAAQEQLAILANSVQINSLPIVQGEKPLDIVKRAIAEAKISAYDVVIYDTAGRTQIDKAMMEEALAIKKIVEPTETLLVIDSMTGQDAVVTASSFNEKLAISGLILSRIDGDSKGGAALSVKYITKKPIKFLSSGENLIDLEEFDAERLASRILDMGDIISFVEKAASIVDREEAEKTAAKLKKGKFDLNDYLQQMRSIKKMGGFGSILSMLPGSGKIMDQIDQSKLNSKIIEHQEAIILSMTPKERKNPDIINASRRKRIAVGAGTTVQKVNILLKQYKQISEIMKKVSKMNPKNLLRSGIGKLFS

Gene
ffh
Protein
Signal recognition particle protein
Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)
Length
449 amino acids
Function
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
Similarity
Belongs to the GTP-binding SRP family. SRP54 subfamily.
Mass
49.318 kDa
Sequence
MFKTLTQNLTKIFDKLVSSGILTEAQIDAAMRDIRVALLESDVALPVIKDFIAEVKQKALGQEVIKSVSPGQMIIKIIHEEMINLLASSESETKLNLNSKPPVNFLMVGLQGSGKTTASSKLALRLKNQNKKVLLVSLDTYRPAAQEQLAILANSVQINSLPIVQGEKPLDIVKRAIAEAKISAYGVVIYDTAGRTQIDKEMMEEALAIKKIVEPTETLLVIDSMTGQDAVVTANSFNEKLEISGLILSRIDGDSKGGAALSVKYITKKPIKFLSSGEKLTDLEEFDAERLASRILDMGDIISFVEKAASIVDREEAEKTAAKLKKGKFDLNDYLQQMRSIKKMGGFGSILSMLPGSGKIMDQIDQSKLNSKIIEHQEAIILSMTLKERENPDIINASRRKRIAAGAGTTVQKVNILLKQYKQISEMMKKASKMNPKNLLRNGIGKLFS

Gene
ffh
Protein
Signal recognition particle protein
Organism
Rickettsia prowazekii (strain Madrid E)
Length
449 amino acids
Function
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
Similarity
Belongs to the GTP-binding SRP family. SRP54 subfamily.
Mass
49.28 kDa
Sequence
MFKTLTQNLTKIFDKLVNSGILTENQIDTAMRDVRVALLESDVALPVIKGFIEEVKQKALGQEVIKSVSPGQMIIKIIHEEMINLLASTESTTKLNLNAKPPVNLLIVGLQGGGKTTASGKLALRLKNQNKKVLLVSLDTYRPAAQEQLAIIANSVNIDSLPIVKGEKPLDIVKRAIGEAQISAYDVVIYDTAGRIQIDNVMMEEALAIKKILNPTETLLVIDSMTGQDAVITAKTFSEKLEISGLILSRIDGDTKGGAALSVKYFTQKPIKFLSSGEKLTDLEEFNAERLASRILDMGDIISFVKKAASIVDREEAEKTAIKLKSGKFDLNDYLQQMRSIKKMGGFGSILSMLPGSGKIFDQIDQSKLNSKIIEHQEAIILSMTLKERKNPDIINASRRKRIAAGAGMTVQKVNILLKQYKQISAVMKKTSKMNPKNLLRSGIGKLFS

Gene
ffh
Protein
Signal recognition particle protein
Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Length
449 amino acids
Function
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
Similarity
Belongs to the GTP-binding SRP family. SRP54 subfamily.
Mass
49.352 kDa
Sequence
MFKTLTQNLTKIFDRLVNSGILTENQIDTAMRDVRVALLESDVALPVIKGFIAEVKQKALGQEVIKSVSPGQMIIKIIHEEMINLLASSESTTKLNLNSKPPVNLLMVGLQGGGKTTASGKLALLLKNQNKKVLLVSLDTYRPAAQEQLAIIANSVNIDSLPIVQGEQPLDIVKRAISEAKIFAYDVVIYDTAGRIQIDNVMMEEALAIKKILNPTETLLVIDSMTGQDAVVTARSFSDKLEISGLILSRIDGDTKGGAALSVKYLTQKPIKFLSCGEKLTDLEEFDAERLASRILDMGDIISFVKKAASIVDREEAERTAIKLKSGKFDLNDYLKHMRSIKKMGGFGSILSMLPGSGKIIDQIDQSKLDSRIIEHQEAIILSMTLKERKNPDIINASRRKRIAAGAGMTVQKVNILLKQYKQISAVMKKASKMNPQNLFRSGISKLFS

Gene
ffh
Protein
Signal recognition particle protein
Organism
Helicobacter pylori (strain J99 / ATCC 700824)
Length
448 amino acids
Function
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
Similarity
Belongs to the GTP-binding SRP family. SRP54 subfamily.
Mass
49.137 kDa
Sequence
MFQALSDGFKNALNKIRFQDDEKALDRALDELKKTLLKNDVHHKVARELLKKVESQTKAGGIGKQQFLDALEKSLLEILSAKGSSGFTFAQTPPTVVLMAGLQGSGKTTTTAKLAHYLKTKNKKVLLCACDLQRLAAVEQLKVLGEQVGVEVFHEENKSVKEIANNALKRAKEAQFDVLIVDSAGRLAIDKELMQELKEVKEVLNPHEVLYVADALSGQDGVKSANTFNEEIGVSGVVLSKFDSDSKGGIALGITYQLGLPLRFIGSGEKIPDLDVFMPERIVGRLMGAGDIISLAEKTASVLNPNEAKDLSKKLKKGQFTFNDFLNQIEKVKKLGSMSSLISMIPGLGNMASALKDTDLESSLEVKKIKAMVNSMTKKERENPEILNGSRRKRIALGSGLEVSEINRIIKRFDQASKMAKRLTNKKGISDLMNLMSQAKNQTPPKMR

Gene
ffh
Protein
Signal recognition particle protein
Organism
Helicobacter pylori (strain ATCC 700392 / 26695)
Length
448 amino acids
Function
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
Similarity
Belongs to the GTP-binding SRP family. SRP54 subfamily.
Mass
49.175 kDa
Sequence
MFQALSDGFKNALNKIRFQDDEKALDRALDELKKTLLKNDVHHKVARELLKKVESQTKLNGIGKQQFLDALEKSLLEILSAKGSSGFTFAQTPPTVVLMAGLQGSGKTTTTAKLAHYLKTKNKKVLLCACDLQRLAAVEQLKVLGEQVGVEVFYEENKSVKEIASNALKRAKEAQFDVLLVDSAGRLAIDKELMQELKEVKEILNPHEVLYVADALSGQDGVKSANTFNEEIGVSGVVLSKFDSDSKGGIALGITYQLGLPLRFIGSGEKIPDLDVFVPERIVGRLMGAGDIVSLAEKTASVLNPNEAKDLSKKLKKGQFTFNDFLNQIEKVKKLGSMSSLISMIPGLGNMASALKDTDLESSLEVKKIKAMVNSMTKKEQENPEILNGSRRKRIALGSGLEVSEINRIIKRFDQASKMAKRLTNKKGISDLMNLMSQAKNQTPPKMR

Gene
ffh
Protein
Signal recognition particle protein
Organism
Mycoplasma mycoides
Length
447 amino acids
Function
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
Similarity
Belongs to the GTP-binding SRP family. SRP54 subfamily.
Mass
50.1 kDa
Sequence
MGFGDFLSKRMQKSIEKNMKNSTLNEENIKETLKEIRLSLLEADVNIEAAKEIINNVKQKALGGYISEGASAHQQMIKIVHEELVNILGKENAPLDINKKPSVVMMVGLQGSGKTTTANKLAYLLNKKNKKKVLLVGLDIYRPGAIEQLVQLGQKTNTQVFEKGKQDPVKTAEQALEYAKENNFDVVILDTAGRLQVDQVLMKELDNLKKKTSPNEILLVVDGMSGQEIINVTNEFNDKLKLSGVVVTKLDGDARGGATLSISYLTKLPIKFIGEGEGYNALAAFYPKRMADRLMGMGDIETLFERAVENIDERSIQKTMNRMFLGQFDLEDLRNQLAQIAKMGSLNKLMKMLPINKVSESQIQEAQRKLAVFSILMDSMTLKERRDPRVLKAISRKNRIIKGSGRSEKEFNELINSFEKGKKQVLEITKMIKSGRMPNLSKGGFKF

Gene
ffh
Protein
Signal recognition particle protein
Organism
Bacillus subtilis (strain 168)
Length
446 amino acids
Function
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components (Probable).
Similarity
Belongs to the GTP-binding SRP family. SRP54 subfamily.
Mass
49.541 kDa
Sequence
MAFEGLADRLQQTISKIRGKGKVSEQDVKEMMREVRLALLEADVNFKVVKDFVKKVSERAVGQDVMKSLTPGQQVIKVVQEELTELMGGEESKIAVAKRPPTVIMMVGLQGAGKTTTSGKLANLLRKKHNRKPMLVAADIYRPAAIKQLETLGKQLDMPVFSLGDQVSPVEIAKQAIEKAKEEHYDYVILDTAGRLHIDHELMDELTNVKEIANPEEIFLVVDSMTGQDAVNVAKSFNEQLGLTGVVLTKLDGDTRGGAALSIRAVTNTPIKFAGLGEKLDALEPFHPERMASRILGMGDVLTLIEKAQASVDEDKAKELEQKMRTMSFTLDDFLEQLGQVRNMGPLDELLQMMPGAGKMKGLKNIQVDEKQLNHVEAIIKSMTVLEKEQPDIINASRRKRIAKGSGTSVQEVNRLLKQFDEMKKMMKQMTNMSKGKKKGFKLPFM

Gene
ffh
Protein
Signal recognition particle protein
Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Length
446 amino acids
Function
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
Similarity
Belongs to the GTP-binding SRP family. SRP54 subfamily.
Mass
50.199 kDa
Sequence
MFKAMLSSIVMRTMQKKINAQTITEKDVELVLKEIRIALLDADVNLLVVKNFIKAIRDKTVGQTIEPGQDLQKSLLKTIKTELINILSQPNQELNEKRPLKIMMVGLQGSGKTTTCGKLAYWLEKKYKQKTMLVGLDIYRPAAIEQLETLSQQTNSVFFAQGTQPVAKTTKAALSAFKTAKCQTIICDTAGRLQTNETLMDELVSVKNELNPDEIIMVVDGLSGQEIINVAQTFHKRLKLTGFIISKLDSDARAGAALSLASLLQVPIKLIGVSEKLDGLEQFHPERIANRILGLGDVMSLVEKAEQVFDKKDLTKTISKMFLGKMDLEDLLIYMQQMHKMGSVSSLIKMLPANFSVSEENAELIENKIELWKVLINSMTREERRHPKLINRDPNRKQRIIKGSGRKMDELNKLMKEWNKMQLKATEMGKLLKTGSNPFGGFGQFF

Gene
ffh
Protein
Signal recognition particle protein
Organism
Thermus aquaticus
Length
430 amino acids
Function
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
Similarity
Belongs to the GTP-binding SRP family. SRP54 subfamily.
Mass
47.356 kDa
Sequence
MFQQLSARLQEAIGRLRGRGRITEEDLKATLREIRRALMDADVNLEVARDFVERVREEALGKQVLESLTPAEVILATVYEALKEALGGEARLPVLKDRNLWFLVGLQGSGKTTTAAKLALYYKGKGRRPLLVAADTQRPAAREQLRLLGEKVGVPVLEVMDGESPESIRRRVEEKARLEARDLILVDTAGRLQIDEPLMGELARLKEVLGPDEVLLVLDAMTGQEALSVARAFDEKVGVTGLVLTKLDGDARGGAALSARHVTGKPIYFAGVSEKPEGLEPFYPERLAGRILGMGDVASLAEKVRAAGLEAEAPKSAKELSLEDFLKQMQNLKRLGPFSEILGLLPGVPQGLKVDEKAIKRLEAIVLSMTPEERKDPRILNGSRRKRIAKGSGTSVQEVNRFIKAFEEMKALMKSLEKKKGRGLMGMFRR