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fer5

Gene
fer5
Protein
Acyltransferase fer5
Organism
Ustilago maydis (strain 521 / FGSC 9021)
Length
427 amino acids
Function
Acyltransferase; part of the gene cluster that mediates the biosynthesis of siderophore ferrichrome A which is contributing to organismal virulence (PubMed:17138696, PubMed:20070524). The first step of ferrichrome A biosynthesis is performed by the HMG-CoA synthase hcs1 which catalyzes the generation of HMG-CoA and CoA using acetoacetyl-CoA and acetyl-CoA as substrates (PubMed:20070524). The enoyl-CoA isomerase/hydratase fer4 then catalyzes the conversion of hcs1-produced HMG-CoA to methylglutaconyl-CoA (PubMed:20070524). The acyltransferase fer5 then fuses the fer4-generated methylglutaconyl-CoA with sid1-generated hydroxyornithine to yield methylglutaconyl hydroxyornithine (PubMed:20070524). Methylglutaconyl hydroxyornithine is then available for use by the NRPS fer3 to generate ferrichrome A (PubMed:20070524).
Similarity
Belongs to the lysine N-acyltransferase mbtK family.
Mass
48.098 kDa
Sequence
MTAATSVQPSPAPRQPGLRATFNPRKEEKVFLARGAHAFTLPGRRASVNVEVDVEAESDEAALDAKETTITVSYAEKGQESSWSAAKWIKLDRLAKTSQHGVVNEDRATYQQAWSLELLDEAVEPARAIWSALYAFWIRHKRSDRLAVLLKGTQATKVRSYVFEAGLGFKSPCETDLILLDRNAFWQGAGAPAGLHWLQTPVPTRGLFPYVLDFTQSTSPPVLATHPLRPPKPAPGSVVYSRYVFSCSQHLELVHIDVSNPQHFDAYTRWQNSDRVNHGWREKGSDEKHRKYITEKNDDPHAMGVLVLWDGVPAGYGEMVWSKEDGMAAFVGGLGNYDQGTHLLIGEEQFRGKHRFTACMVSLKHACFLRDPRTEVVVGEPRYDLDIIPLLATFLPQEIRKEVELPHKRAVFFVLRRDRFLEEGILE