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Flap endonuclease 1

351 amino acids

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.

39.657 kDa

MDLAELVEEIKKELSFAELKGKKISIDAYNALYQFLAAIRQPDGTPLMDSQGRVTSHLNGLFYRTISILEEGIIPIYVFDGKPPEQKAQELERRKKVKEEAEKKLEQAKTEGSIKTSELKKYAQMSIRLTNEMAEESKELLKAMGIPVVQAPSEGEAEAAYINILGLSWATASQDYDSLLFGAKRLIRNLTLSGKRKLPGKDVYVEIKPELIELDTLLKKLGLTREQLIDIGIIVGTDYNPDGIKGYGVKTAYRIIKKYGSLEKAIEKGEIPKIKVNFNVEEIRSLFLKPQVVEPKENLELVDCDSNKILDILVKTHDFNEERVKNGIERLEKAKREAKGASRQTGLDQWF

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Flap endonuclease 1

350 amino acids

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.

40.04 kDa

MGVNLRELIPPEARREVELRALSGYVLALDAYNMLYQFLTAIRQPDGTPLLDREGRVTSHLSGLFYRTINLVEEGIKPVYVFDGKPPEMKSREVEERLRRKAEAEARYRRAVEAGEVEEARKYAMMAARLTSDMVEESKELLDAMGMPWVQAPAEGEAQAAYMARKGDAWATGSQDYDSLLFGSPRLVRNLAITGRRKLPGRDQYVEIKPEIIELEPLLSKLGITREQLIAVGILLGTDYNPGGVRGYGPKTALRLVKSLGDPMKVLASVPRGEYDPDYLRKVYEYFLNPPVTDDYKIEFRKPDQDKVREILVERHDFNPERVERALERLGKAYREKLRGRQSRLDMWFG

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Flap endonuclease 1

350 amino acids

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.

39.604 kDa

MGVTELGKLIPDNLRRRVSLEQLNGKLIALDAYNALYQFLASIRQPDGTPLMDSQGRVTSHLSGLLYRTINLLEYGIKPVYVFDGKPPELKLIEIEKRRRVREKAVEDWIKAVEEGKKSEARKYAQRALFITSDMVDEAKRLLDSMGVPWVQAPSEGEAQAAYMASKGIVWAAGSQDYDSFLFGAPRLVRNLTISGRRKLPGRDEYVEVTPELIELNDVLKALRLRDRGQLIDLAILLGTDYNPEGIPGIGPQRALRLIQEYGSLDKLMNTVLKNAQFPVDPFKIREFFLNPPVTQEVNVKFKEPNEDEVVRLLVEEHDFSQDRVKNALERLRKSMGKAKGSTTLDSFFG

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Flap endonuclease 1

350 amino acids

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.

40.038 kDa

MGVNIREVIPPEAIQEIDLAHLKYKVVAIDAYNALYQFLTAIRQPDGTPLMDSKGRITSHLSGLFYRTINLMEHGIKIVYVFDGKPPEMKYLEIERRKRVKSEAVKKYEEAVKKGDTKAARRYAQMAARLTDEMVEDAKKLLDAMGVPWVQAPAEGEAQAAFMARRGDAWAAASQDYDSLLFGSPRLVRNLAITGRRKLPRKDVYVEIKPELIELDKLLKALGITREQLVALGILIGTDYNPDGVKGIGPKTALKMVKAHRDPVKLLQGLPRHEFPTDPLKIYEYFLNPPVTTDYKLEWREPDEKKVFEILVEGHDFSPERVRNALERLKKAYREHFRGQQMGLDAWLRR

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Flap endonuclease 1

350 amino acids

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.

39.91 kDa

MGVTALRELIPSKCKKTLELKSLSNKSVALDAYNTLYQFLAAIRGEDGRPLMDSKGRVTSHLSGLFYRTINMLENGIKVAYVFDGAPPKLKTREIERRQKLKQEAEKKYEEAVRRGDVEEARKYAQMSAKLTKEMVEEAKRLLEAMGVPWVQAPSEGEAQAAYMAAKGDVWASASQDYDSLLFGSPRLVRNLAVSGRRKLPNKNVYVEVKPEEITLKCVLEELGITREQLVAIAVLIGTDYTPGVKGVGPKTALRYVKSYGDLERVLTALGVDDKELYLEAYNFFLNPQVTDDYELVWRRPDPQKIIEILVYEHDFNEERVRKAIERLMKAWKEKLSTKQSTLDMFFKKR

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Flap endonuclease 1

350 amino acids

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.

39.956 kDa

MGVNLKDLIPEEAKMTIEDLRMLRGKIVVIDGYNALYQFLTAIRQPDGTPLMDSQGRITSHLSGLFYRTINILENGIKPAYVFDGKPPEIKAKEIEKRRKIREDASKKYEEALRKGDIEAARRYAMMSAKLTDEMVQDAKKLLDAMGIPWIQAPAEGEAQAAYIVSKGDAWASASQDYDSLLFGSPRLIRNLTISGKRKLPRKNVYIEIKPEIIELKKLLEKLGLTREQLIYVAILIGTDYNPDGVKGIGPKKALQLVKAYKTLDKILKIIPKTEFPIEPEKIVEYFLNPPVSTDYKLEWRAPDESKIREILVEEHDFNPERVKNAVERLVKAYREHIKSKQLGLEAWFS

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Flap endonuclease 1

349 amino acids

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.

39.152 kDa

MGVTELGKLIGREARREIKLENLAGRCIALDAYNALYQFLASIRQPDGTPLMDRQGRVTSHLSGLFYRTINLMEAGIKPVYVFDGKPPEFKLAEIEARRRVKEKAMEEVVKAIREGKRDDVAKYMKRVIFLTNEMVEDAKRLLTYMGVPWVQAPSEGEAQAAHMAKRGHCWAVGSQDYDSLLFGSPRLVRNLAVSPKRRSGEEVVEVSPEVVELDSVLKALKLKGREQLIDVAILLGTDYNPDGVPGVGPQKALKLVLEFGSLEKMLDTVLRGVSFPVDPLEIKRFFLNPPVTEEYALELKNVDERGLVNFLVGEHDFSEERVAKAVERLKKARARQKTSSLDSFFHGA

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Flap endonuclease 1

349 amino acids

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity). DNA polymerase I, DNA ligase and the flap endonuclease may be constitutively associated with the PCNA heterotrimer forming a scanning complex able to couple DNA synthesis and Okazaki fragment maturation.

Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.

39.598 kDa

MDLADLVKDVKRELSFSELKGKRVSIDGYNALYQFLAAIRQPDGTPLMDSQGRVTSHLSGLFYRTINILEEGVIPIYVFDGKPPEQKSEELERRRKAKEEAERKLERAKSEGKIEELRKYSQAILRLSNIMVEESKKLLRAMGIPIVQAPSEGEAEAAYLNKLGLSWAAASQDYDAILFGAKRLVRNLTITGKRKLPNKDVYVEIKPELIETEILLKKLGITREQLIDIGILIGTDYNPDGIRGIGPERALKIIKKYGKIEKAMEYGEISKKDINFNIDEIRGLFLNPQVVKPEEALDLNEPNGEDIINILVYEHNFSEERVKNGIERLTKAIKEAKGASRQTGLDRWF

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Flap endonuclease 1

349 amino acids

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.

39.777 kDa

MDLGEIVEDVKREINLNEMKGKKISIDAYNTIYQFLAAIRQPDGTPLIDSKGRITSHLNGLFYRTISIIESGIIPIFVFDGKPPEKKSEEIERRKRAKEEAEKKLEKAKLEGEYREIRKYAQAAVRLSNEMVEESKKLLDAMGIPVVQAPGEGEAEAAYINSIDLSWAAASQDYDSLLFGAKRLVRNITISGKRKLPNKDVYVEIKPELIELESLLKKLGINREQLIDIAILIGTDYNPDGVKGIGVKTALRIIKKYNNIENAIEKGEIQLSKINFDIREIRKLFITPEVKKPTERLELAECNEREIIELLVKNHDFNEDRVNNGIERLKKAIKEAKSVEKQTGLDQWF

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Flap endonuclease 1

348 amino acids

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.

40.252 kDa

MGLAELRELIEPEETDLRALAGREIAIDAFNALYQFLTTIMKDGRPLMDSRGRITSHLNGLLYRTVNLVEEGIKPVYVFDGEPPDLKRETLERRRERKEEAMEKLRRAKTKEEREKYARQVARLDESLVEDAKRLLDLMGIPWVQAPSEGEAQCAYMARCGDVWATGSQDYDSLLFGSPRLVRNITIVGKRKHPHTGEIIEVKPEIMRLEDVLDQLGLESREQLVDLAILLGTDYNPDGVPGIGPKRALQLIRKYGSLDELKDTDIWPKIERHLPVEPEKLRRLFLEPEVTDDYELDWDEPDEEGLVEFLVEERDFSEDRVRRAVERLKEALQELRKGGRQETLDAFF

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Flap endonuclease 1

346 amino acids

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.

39.099 kDa

MGVTELGKLIGKEVRREVKLESLSGKCIALDAYNALYQFLASIRQPDGTPLMDRAGRITSHLSGLFYRTINLLEAGIRPVYVFDGKPPEFKLAEIEERRKTREKAMEEVLRAIKEGRREDVAKYAKRAVFITSEMVDEAKRLLSYMGVPWVQAPSEGEAQAAYMARKGHCWAVGSQDYDSLLFGSPKLVRNLAVSPKRKIGEEVIELTPEIIELDAVLRALRLKNREQLIDLAILLGTDYNPDGVPGVGPQKALKLIWEFGSLEKLLETVLKGAYFPIDPLEIKKFFLNPPVTDQYATEVRDPDEAALKDFLIREHDFSEERVSKALERLRKARGKLKTSSLDSFF

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Flap endonuclease 1

346 amino acids

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.

38.993 kDa

MGVTELGKLIGKEARREVKLEALAGRCVALDAYNALYQFLASIRQPDGTPLMDRAGRITSHISGLFYRTINLMEAGIKPVYVFDGKPPEFKLAEIEERRKAKEKATEELVRAIKEGRRDEVAKYAKRAIFLTNEMVEDAKKLLTYMGVPWVQAPSEGEAQAAYMARRGHCWAVGSQDYDSLLFGSPRLVRNLATSPKRKVGDEVVELSPEIIELDAVLKSLRLRSREQLIDLAILLGTDYNPDGVPGIGPQRALKLIWEFGSLEKLLDTVLRGVTFPIDPVEIKRFFLNPPVTDTYTTDVTKPDDAKLRDFLVHEHDFGEERVERALERLKKAMGKLRTSALDSFF

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Flap endonuclease 1

346 amino acids

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.

38.744 kDa

MGVTELGKLIGKEARREIKLESLAGKCVALDAYNALYQFLASIRQPDGTPLMDRAGRITSHLSGLFYRTINLLEAGVKPVYVFDGKPPEFKLLEIEQRKKAKEKALEEVEKAIREGRREDVAKYAKRAIFLTSEMVEDAKKLLTYMGIPWVQAPSEGEAQAAHMAKRGHCWAVGSQDYDSLLFGSPRLVRNLAVSPKRKVGEEVVELSPELIELDAVLKSLKLKGREQLIDLAILLGTDYNPEGVPGVGPQKALKLIWEFGSLEKLLQTVLKGVQFPVDPLKIREFFLNPPVTDQYSTELSTPDERKIVELLVEEHDFSQERVAKALERLAKARGKVKTTSLDAFF

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Flap endonuclease 1

346 amino acids

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.

39.274 kDa

MGVTELGKLIGKDIRREVKLENLAGKCIALDAYNSLYQFLASIRQPDGTPLMDRVGRITSHLSGLFYRTINLMEAGIKPVYVFDGKPPEFKLAEIEERRKVKEKAMEEVLKAIKEGRKEDVAKYMKRAVFLTSDMVEDAKKLLTYMGVPWVQAPSEGEAQAAHMAKRGHCWAVGSQDYDSLLFGSPRLVRNLAVSPRRKIGEEVIELSPEIIELDAVLKSLRLKNREQLIDLAILLGTDYNPDGVPGVGPQKALKLVWEFGGLEKMLETVLRGVYFPVDPLEIKKFFLNPPVTDEYSTDIKKPDEQKLIDFLVREHDFSEDRVLKAVERLKRAQTKYKISSLDSFF

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Flap endonuclease 1

346 amino acids

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.

39.575 kDa

MGVDIKELVEPVAKEVELGFFSKKVIAIDAYNSLYQFLATIRQKDGTPLLDAQGNVTSHLNGLFYRTINYIELGIKPVYVFDGRPPELKQKELERRYQIKVEAEKKYREAIERGDLEEARIYAQQTSRLTAAMVHDAKLLLRYMGVPYVEAPSEGEAQAAYMVKKGDAWASGSQDFDSLLFGSPRLVRNLAITGKRKLPRKDVYVEVKPEIVELEELLRVHGITHQQLVVIGILVGTDYAPEGARGIGVKKALKLVKELKDPEKIFRSVEWSSDVPPEKILELFLHPEVTDSYELTWKEPDKEKVIELLVERHQFSMERVTNALDRLEKAVKTHFKQQSLESWFGF

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Flap endonuclease 1

343 amino acids

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.

38.949 kDa

MGVPIGELIPRKEIELENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSHLSGLFYRTINLMEAGIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKYAQRATKVNEMLIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFGTPRLVRNLTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPGGIKGIGPKKALEIVKYSKDPLAKFQRQSDVDLYAIKEFFLNPPTTDDYSLKWKEPDEEGIIRFLCDEHDFSEERVKNGLERLKKAIKAGKQSTLESWFIKKKP

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Flap endonuclease 1

343 amino acids

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.

38.947 kDa

MGVPIGDLVPRKEIDLENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSHLSGLFYRTINLMEAGIKPAYVFDGKPPEFKRKELEKRREAREEAELKWKEALAKGNLEEARKYAQRATKVNEMLIEDAKKLLQLMGIPIIQAPSEGEAQAAYMASKGDVYASASQDYDSLLFGAPRLIRNLTITGKRKMPGKDVYVEIKPELVVLDEVLKELKITREKLIELAILVGTDYNPGGVKGIGPKKALEIVRYSRDPLAKFQRQSDVDLYAIKEFFLNPPVTNEYSLSWKEPDEEGILKFLCDEHNFSEERVKNGIERLKKAIKAGRQSTLESWFVKKKP

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Flap endonuclease 1

342 amino acids

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.

38.576 kDa

MGVKIGELIEDKVELELSDIAGKKIALDAFNAMYQFLAKVRQPDGTPLMTSKGEITSVHSGIFYRTANFLKEGIIPIYVFDGEKPSFKSRAIEERVRAREEAELKWKEALEIGDLEEARKYAQAALNITGDIVEDCKTILKLMGVPIVQAPSEGEAQAAHMAMKGDVWATASQDYDSLLFGAPRLIRNLTITGKRKLPGKEVYVDINPELIELESVLKRNGISREQLIMIGILVGTDYNLGGVKGIGVKRALELVKKYKRPEDLFSKVPWEFDVDPISIYEFFLNPPTTDDYDTSLKRPMSDELLKFMVEEHEFSEERVKKVINEIEESYRMLSGGGLESWF

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Flap endonuclease 1

341 amino acids

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.

38.991 kDa

MGVQIGELIPRKEIELENLYGRRVAIDAFNAIYQFLSTIRQRDGTPLMDSQGRITSHLSGLFYRTINLMEAGIKPAYIFDGKPPDFKKRELEKRREAREEAEEKWYEALERGDLEEAKKYAMRATRVNEGLINDAKTLLELMGIPVIQAPSEGEAQAAYMAAKKKVYASASQDYDSLLFGAPKLVRNLTITGRRKLPGKNVYVEVKPELIVLEEVLKELSIDREKLIEMAILVGTDYNPGGIKGIGPKKALTIVKRTKDPLKKYQKESEVDLYAIKEFFLNPPVTDDYELKWREPDEEGIIKFLCDEHDFSEERVKNGLERLKKAVKAGKQSTLESWFGRR

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Flap endonuclease 1

340 amino acids

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.

37.928 kDa

MGLDLKALVSREPTRLESFATKVVAIDAYNAIYQFLATIRGPDGMQLTDARGRVTSHLSGLLYRNASFLSMGIKPVYVFDGRPPTLKSAEIERRRNVKKGAAVKYAAAVDAGNMDDARKYAQQTTSMRDGMVDDSKQILKLFGIPYIDAPSEGEATAAYLTQTGDAYASASQDFDSVLFGAKRLVRNFTNSGRRKIPNRNMYVDVQPEIIETEKTLTTLDLTREQLVDVGILIGTDFNPDGFERIGPKTALKLVHEHGRLEDIPRIQDELGSVSYAEIRKIFLEPESPGNIEIEFGATDYDGITKYLVGERSFSEDRVAAALNRLRRALEKRSQNLDQWF

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Flap endonuclease 1

340 amino acids

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.

37.779 kDa

MGVDLGGLVEPREIELKELNNRTVAVDAYNTLYQFLSIIRQQDGAPLADDRGNVTSHLSGIIYRVTNLVEEGMKPVFVFDGKPPSFKAETIKARAEVREAARQMYEAAKAAGSAEAYKYAQASTSINRQIVDDAKVLLGYMGIPFIVAPSEGEAQAAYMVSRGAADYVGSQDYDSLLFGAPRVVRNIAITGKRKVPRKNIYMDVKPEVIELQEVLATLGLTREELIDMAILVGTDYNPGIFKVGPKTALKLVKKHGDNMPAILDELGQTIENWEAIKEFFLHPTVTDDYQVKWGKPEPAKIKEFLCEEHSFSVDRVDKVLERLTTAVSETTKQKTLSSWF

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Flap endonuclease 1

340 amino acids

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.

38.589 kDa

MGLNLKDLVVREKTTLEAFSNKVIAIDAYNAIYQFLASIRGPDGLQLSDSEGRITSHLSGLLYRNVNFLSLGIKPVYVFDGKPPSLKTAEIERRKQIKMDATIKYEKAIADGNMEDARKYAQQTTSMKDGMVKESKQLLTYFGIPYIEAPSEGEATAAHLTNTGQAYASASQDFDSILCGAKRLVRNFTNSGRRKIPNKNTYIDIVPEIIETQKTLDSLELTREELIDVGILIGTDFNPNGFERVGPKTALKMIKQHSKLEEIPQIQEQLEEIDYQEIRKIFLNPEVADVKEIVFENVNYEGMSNYLVRERSFSEDRVNSTLNRLKKALEKKSQNLDQWF

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Flap endonuclease 1

340 amino acids

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.

Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.

38.739 kDa

MGVPIGEIIPRKEIELENLYGKKIAIDALNAIYQFLSTIRQKDGTPLMDSKGRITSHLSGLFYRTINLMEAGIKPVYVFDGEPPEFKKKELEKRREAREEAEEKWREALEKGEIEEARKYAQRATRVNEMLIEDAKKLLELMGIPIVQAPSEGEAQAAYMAAKGSVYASASQDYDSLLFGAPRLVRNLTITGKRKLPGKNVYVEIKPELIILEEVLKELKLTREKLIELAILVGTDYNPGGIKGIGLKKALEIVRHSKDPLAKFQKQSDVDLYAIKEFFLNPPVTDNYNLVWRDPDEEGILKFLCDEHDFSEERVKNGLERLKKAIKSGKQSTLESWFKR

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Flap endonuclease 1

340 amino acids

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.

38.754 kDa

MGVQIGELIPRKEIELESLYGKKVAIDAFNAMYQFLSTIRQRDGTPLMDSQGRITSHLSGFFYRTINLMEAGIKPAYVFDGKPPDFKKRELEKRREAREEAEEKWYEALEKGDLEEAKKYAMRATRVNEELINDAKKLLELMGIPVVQAPSEGEAQAAYMAAKKAVYASASQDYDSLLFGAPRLVRNLTITGRRKLPGKNVYVEVKPELVVLEEVLKELGIDREKLIELAILVGTDYNPGGIKGIGPKKALTIVKRTKDPLAKYQKESDVDLYAIKEFFLNPPVTDDYELKWREPDEEGILKFLCDEHDFSEERVKNGLERLKKAVKAGKQRTLESWFGR

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Flap endonuclease 1

340 amino acids

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.

38.701 kDa

MGVPIGELLPKKELELENLNGRKVAIDAFNAIYQFLSTIRQKDGTPLMDSKGRITSHLSGLFYRTINLMEAGIKPAYVFDGKPPEFKKKELEKRAETREEALEKWEIALARGELEEAKKYAQRASKINEILIEDAKKLLELMGIPWVQAPSEGEAQAAYMASKGDVWASASQDYDSLLFGTPKLVRNLTITGKRKLPGKDVYIEVKPELILLEDVLKELKLTREKLIELAILVGTDYNPGGIKGLGPKKALEIVKYSKDPLSKYQKTSEVDLYAIKEFFLNPPTTNDYKLEWKLPDEESIIKFLCDEHDFSEERVKNGLERLKKVTKTGKQFTLDTWFKK

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Flap endonuclease 1

339 amino acids

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.

38.967 kDa

MGVNLKEIVDPVKKEIEFKQLFGKVIAIDAFNALYQFLFSIRQDGEPLRDSKGRITSHLSGLFYRTINLLEYGIKPIYVFDGTPPKFKIVAWEKRKKHKEQLESKYKEALKKGNIQEAIKYAKSLGKLDSYMVEEAKKLLEAMGIPYVQAPSEGEAEAAYLTKKGVSDYCGSQDYDSLLFGSPRVVRNITISEKRKLPGKNIYVEVKPEVIELEAVLNYWKITREQLIAIAMLLGTDYNEKVPGIGPKTAIEIVKRFGDPIKVIEYYKIPNGKEIFEFFLNPPVIDFEPKWGKPNKELIFKILVEEHDFNPERVERAIERLEKALNKINQKTLFSFFGS

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Flap endonuclease 1

339 amino acids

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.

38.698 kDa

MGVQIGELVPRKEIELENLYGKKVAIDAFNAMYQFLSTIRQRDGTPLMDSKGRITSHLSGFFYRTINLMEAGIKPAYVFDGEPPAFKKKELEKRREAREEAEEKWHEALERGEIEEAKKYAMRATKLNETLIEDAKKLLGLMGVPVVQAPSEGEAQAAYMAAKKRVYASASQDYDSLLFGAPRLVRNLTITGRRKLPGKNVYVEVKPELIVLEEVLRELGIDREKLIELAILVGTDYNPGGIKGIGPKKALTIVKRSKDPLKKYQKDSDVDLYAIKEFFLNPPVTDDYELKWREPDEEGILKFLCDEHDFSEERVKNGLERLKKAVKAGKQRTLESWFR

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Flap endonuclease 1

338 amino acids

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.

38.164 kDa

MGTDIGDLLQKRKIELSDLSNRVVAVDAFNTLHQFLSIIRQRDGSPLVNSRGKVTSHLSGLLYRTASLVEAGIKPVFIFDGKPPDLKSETLSRRKEVRETSLEKWENAKAEGDLEAAYKYAQASSRVDQEIVEDSKYLLGIMGIPWIQAPCEGEAQAAHMVLKKDADYVASQDYDSFLFGAPKVVRNMAVTGKRKLPGKNVYVDVELEVIELEETLRALEINRDQLIDIAICVGTDYNKGLEKVGPKTALKLIKKHGDIHAVLREKDMEIEGLDRIRKLFTHPEVTEDYEIKWTKPDSEKLIKFLCEENDFSTDRVEKAAERLKAASGARQKTLDQWF

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Flap endonuclease 1

338 amino acids

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.

38.212 kDa

MGTDIGDLLQKRKIELSDLTNQVVAIDAFNTLHQFLSIIRQRDGNPLVNSRGKVTSHLSGLLYRTASLIEVGIKPVFIFDGKPPDLKSETLNRRKEVRESSLEKWENAKVEGDLEAAYKYAQASSKVDQEIVEDSKYLLSIMGIPWIQAPCEGEAQAAHMVLKKDADYVASQDYDSFLFGAPTVIRNLAVTGKRKLPGKHVYVDVELELIELEETLGVLGINREQLIDIAICVGTDFNKGLEKVGPKTALKLIKKHGDIHAVLREKGVEIKELDRIRELFTHPDVTDDYEIKWGKPDSEKLIKFLCKENDFSVDRVKKAVERLKVVSRGRQQTLDQWF

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Flap endonuclease 1

338 amino acids

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.

37.762 kDa

MGTDIGDLLLKDTIEIAGLSNKVVAIDAYNTLYQFLSIIRQRDGTPLKDSRGQITSHLSGILYRLTSLIEAGVKPIFVFDGKPPDFKSDTLAKRHEVRESATAKWEDAKAQGLEEEAYKYAQASSKVTREMIDDSVRLLELMGIPYVKAPSEGEAQASYMVQKGDADYIGSQDYDSFLFGAPQVVRNLTITGKRKLPKKNIYVDVKPEVLSLVDSLGELGITRQQLIDIAMCVGTDYNTGLENIGPKRALKLVKEHGDIKVVLKELGKDIEDLDAKRDFFMNPPVTDDYELKWIKPDRAGVIDLLCKKHDFSEERVNKALDRLEANIGGSQSTLDQWF

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Flap endonuclease 1

338 amino acids

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.

37.711 kDa

MGTDIGDLLQKRKIELSDLSNRVVAVDAFNTLHQFLSIIRQRDGSPLVNSQGKVTSHLSGLLYRTASLVEAGIKPVFVFDGKPPEMKTGTLNRRKEIRESSKEKWENAKAEGNLEAAYKYAQASSKVDQDIIEDSKYLLDIMGIPWIQAPCEGEAQAAHMVLKKDADCVASQDYDSFLFGAPTVVRNLAATGKRKLPGKNVYVDVELEMIELEETLDSLGINRDQLIDIAICVGTDYNKGLEKVGPKTALKLIKKHGNIHAVIREKGMEIEALDSIKELFTHPDVTDDYEIKWGKPDSEKLINFLCDENDFSEDRVVKAADRLKAASGARQQTLDQWF

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Flap endonuclease 1

338 amino acids

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.

38.125 kDa

MGVNLSSILIKHETSLKDNSGSIVSVDAYNIIYQFLSSIRGDDGEPLKDSNGNITSHLSGIFYRTSNLLENNIKPVYVFDGKPFHLKSETLRERSLIKEKNIMKLEEAIASNDDAKIRSLSSRINYITDDIVNESKTLLNLMGLPYVQAPSEGEAQASYMTLKGDVNAVVSQDYDCLLFGAKRILRNFTVYGRRRIAGTSRTINVNPEIIDLNENLSNLGISREQLIYIGILTGTDFNPGVKGIGAKTALSLIKKYNDIYSVIKIKNIGIDNLDEIIEFFMNPPHNDYEIKFNEPDFDGIIDFLCGKHNFSESRVNETLEKISRNYKKDHQSSLDRFF

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Flap endonuclease 1

336 amino acids

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.

38.065 kDa

MGADIGDLFEREEVELEYFSGKKIAVDAFNTLYQFISIIRQPDGTPLKDSQGRITSHLSGILYRVSNMVEVGIRPVFVFDGEPPEFKKAEIEERKKRRAEAEEMWIAALQAGDKDAKKYAQAAGRVDEYIVDSAKTLLSYMGIPFVDAPSEGEAQAAYMAAKGDVEYTGSQDYDSLLFGSPRLARNLAITGKRKLPGKNVYVDVKPEIIILESNLKRLGLTREQLIDIAILVGTDYNEGVKGVGVKKALNYIKTYGDIFRALKALKVNIDHVEEIRNFFLNPPVTDDYRIEFREPDFEKAIEFLCEEHDFSRERVEKALEKLKALKSTQATLERWF

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Flap endonuclease 1

336 amino acids

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.

37.518 kDa

MGVDLGDILSKKKISLENLSGCWIAVDGFNTLYQFLSIIRQPDGTPLMDASGRVTSHLSGLLYRMTNLIEVGIRVAFVFDGTPPELKAGTLAARAQMKEAAEIQLQEAIATGVDSFRYAQATARINSEILHDSIRLLDAMGIPYVQAPSEGEAQAAFMAIRGDVDYVASQDYDSLLFGAPRVVRNLAITGRRKMPRKNIYIDVPPEVIILEEELTRLGISREQLIDIGIMCGTDYNRGLPKVGPKRALKLIREHGCLEAVLDALGESIENFREIRELFLHPAVTESYELRMRKPMVDEIVGFLCNERNFSEDRVRKAAERLNASYRSGQSTLERWL

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Flap endonuclease 1

336 amino acids

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.

38.772 kDa

MGTDISDIVVSHETSLKDQGNQTFSIDTYNILYQLLSNVRQYDGMPLMDSHGNVTSHLYGIFYRTINLLENRIRPVYVFDGKPSPLKNRTISERQMMKEKAKAELEEAIERGEEDLRQYYSRINYITPQIVDDTKKLLDYMGIPYVDAPSEGEAQASYMTKKNVDGVISQDYDCLLFGARKILRNFAIYGRRKVPRKNIYKTVYPEYIILDEVLSANQINQDQLIGIGILVGTDFNEGIKGIGAKKALALIKKEGDIKSVLKHIGKNIENLDEIIDFFKNPPVVDYDFKFRKPDTDAIEHFLCDEHDFSRERIRDHLESLRKNDQASTQFRLDSFD

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Flap endonuclease 1

335 amino acids

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.

38.264 kDa

MGTDISDIVVSHQTSLKDQANQVFAIDTYNILYQLLSNVRQYDGTPLMDSSGNVTSHLYGIFYRTVNLVENGIKPIFVFDGKPSPLKNRTLEIRQLAKEKAKAELEEAISRGEENLKQYYSRINYITPQIVNDTKELLTYMGIPYVDAPSEGEAQASYMTRKDADGVISQDYDCLLFGAKKILRNFAIYGRRKVPRKNVYRTVYPEYVMLDEVLKKNGINQDQLIEIGILVGTDFNEGIKGIGAKKALALIKKEGNIKAVLNKIGKNIENLDEIIDFFKNPPVVDVKYVFGKPDPKKIEEFLCVVHDFSRDRILEHINTYVKYYNKSVQFRLDSF

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Flap endonuclease 1

333 amino acids

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.

36.45 kDa

MGVALRDILADYKTPVTWEGLSGVAAVDANNTLYQFLTIIRQPDGTPLMDAKGRVTSHLSGILFRMVNFLEKGIKPVFVFDGKPPELKQETNAERKKLRDEAGEKYKEAVERGDEEEAYRQARSATRVDETIIATSKELLDLLGIPYVQAPSEGEAQAAFMVQRGDARFAVSQDYDTLLFGAPLLMRNLTVSGKRKIRGRAVTVNPERLVLSEVLSGLSLTREQLVEVGILVGTDFNPGAAGVGAKTALKIVKSGGFAQKLAEKCPGFDPAPVADFFLKPPVTTEYELAWGHPCVEGIKKMLCDGYDFAPERVDAALERYSAKAGQKTLESFF

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Flap endonuclease 1

333 amino acids

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.

37.157 kDa

MGVALRDILTDLKRPAETDELKGVAAIDAFNALYQFLSIIRQPDGTPLMDDSGRITSHLSGIFFRTANFLTQGIRPVFIFDGKSPEMKGRTIQERRDVREESKEKWDQAKKEGDLAGAFRYAMSSTAIDAYILSSARQLIQLMGLPVVDAPSEGEAQGAYMVLKGDADYVVSQDYDTLLFGTPVLVRNLTISGKRRLHGRQITVQPERIVLSDVLSTLDITREQLIEIAILTGTDFNPGIRGIGAKTGLKKIKSGEFDSIIREKLPDFDPEPVRSFFLNPPVTDSYTLDPGRIDRDGIRAFLCGEHGFSQDRVDPVLDKISKKEKQKTLESWF

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Flap endonuclease 1

333 amino acids

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.

36.492 kDa

MGVALRPLLAEYKESPGWDGLGGIAAVDAFNALYQFLSGIRQADGAPLMDGQGRITSHLSGLLFRNANLIEKNITPIYVFDGKPPVFKASTLSKRREVRENAADAWEKALKEGDEESARKYAMASSKIDAFIIDSSKELLSALGIAWIQAPEEGEAQSSFMTKNGDVTYAVSQDYDSLLFGAPDLVRNITVSGKKRIRGKVLSVYPERLRLEEVLTGLSVTQEELIQIALLIGTDYNSGVPGVGPKTAVKIVREGKFYDRIGESENAAEPDQLIGYFMDPPVERSYNIESRSPDPDRVIDLLCGEHGFTQERVEAGLERLGAKKGQATLDAWF

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Flap endonuclease 1

333 amino acids

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.

37.1 kDa

MGVAIRDILADCKETLTWDDLSGIAALDAHNALYQFLSIIRQPDGTPLMNGAGRITSHLSGILFRTVNFLEKGIRPVFVFDGKPPEFKQETINERREHRARADEAWKTALREGDMEEAYKQASASARIDSHTIASSRELLDLLGIPWVQAPSEGEAQAAYMARQGKVTYAVSQDYDSLLFGSPVLVRNLTVSGRRKTRGRTITVNPERIVLSSFLDRLGVTREQLVKIGILVGTDFNPGIRGVGGKTALKIVRNGEFESVIAEKQPDFNPAPIRDFFLNPPVTDDYTLEWRTPDVEGVVEMLCGRYDFSEERVRSALAKVSVKATQKTLDAWF

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Flap endonuclease 1

333 amino acids

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.

36.493 kDa

MGVALREVLTEYKHPRTWETLAGTAAIDGNNALYQFLSIIRQPDGTPLMNSEGRITSHLSGVFFRTLRFLEKGIRPVYIFDGKPPALKQETIESRREVRREAGVQWEAALARGDQEEAYKQARASSRVTPEIIATSKELLTLMGVPCVQAPSEGEAQAASMAASGAVTYAVSQDYDSLLFGAPLLVRNLTVSSKRRVQGRTIAVQPESIRLDEVLGGLGITREQLIEAGILIGTDFNPGIRGVGPKTALKIVKKDGFADMIAEKLPDFDPSPILQFFRSPPVIANLSLDWQPPDQAGIEDLLCGEYGFATERVRTALQKISGPPGQKTLDRWF

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Flap endonuclease 1

328 amino acids

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.

37.297 kDa

MGVKFKDITNPEPIEMKELEGKILTVDASNVIYKFLSSMRQTDGTPLRDLNGHITSHLNGIMFQTSTLIEKDIKPVYVFDGKAPDLKKETQEERINIKKESEKKYLEAKEVGDVVAARKYAARTTHLNKEIIKSSKKLLDLMGIPYVQARTEGEAQASYMVSQNDAWAVVSQDYDCLQFGATRMIRNLKLSKSNSKNLELISLEKTLKELNLTREQLVDVAMLVGTDFNKGVYGIGAKKGIKLIHKYGTLEKALESLNETMEVDAELIREIFLNPNVVHNYTIEFKRPKKSQLLDFLCGEHDFDERRTISAIKKLQAKTAQSSLEDWF

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Flap endonuclease 1

328 amino acids

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.

37.17 kDa

MGVKLRDVVSPRRIRLEDLRGRTVAVDAANTLYQFLSSIRQRDGTPLMDSRGRVTSHLSGILYRTAAVMEREIRVIYVFDGRSHHLKGETVSRRADIRKKSEVEWKRALEEGDIDRAKKYAVRSSRMSSEILESSKRLLELLGIPYVQAPGEGEAQASYMVKMGDAWAVASQDYDCLLFGAPRVVRNLTLSGKLEDPEIIELESTLRELSISHTQLVDMALLVGTDFNEGVKGIGARRGLKLIREKGDIFKVIRDLEADIGGDPQVLRRIFLEPEVSEDYEIRWRKPDVEGVIEFLCTEHGFSEDRVRAALKKFEGASSTQKSLEDWF

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Flap endonuclease 1

328 amino acids

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.

36.413 kDa

MGNADLRTLAAIEPKPFDELGGSVVAVDAHNWLYRYLTTTVKFTRSEAYTTADGEEVANLIGVVQGLPKFFEHDVTPVFVFDGGVSDLKADEVEKRRDQRERYEAQLEAAKERDETDAAEIAALESRTQRLTDTIVETTRELLARLDVPVVEAPAEGEAQAAHMARRGDADYVGSEDYDALLLGAPYTLRGLTSNGDPECMDFEATLSTHDLSWEGLVDAAILMGTDFNEGLSGVGPKTAVKLIHEHGDLRSVLAARDDDIPHADRIRELFLDPAVTDDYDYDTDIDPDFERAREFVTETWGVPADEVERGFERIEESVIQTGLDRWT

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Flap endonuclease 1

327 amino acids

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.

35.814 kDa

MGNADLRQLAAIEETPFADLEGSVVAVDAHNWLYKYLTTTVQWTGADVYTTSDGTEVANLVGAVQGLPKFFEHGLTPVFVWDGGVTELKDDEIADRREQRERYEEQLDDAREAGDAAEAARLDARTQRLTPTIHETTRELFDLLDIPQVEAPAEGEAQAAYMTRTDDAVDYAGSDDYDCLLLGSPVTLRQLTSSGHPELMDFDATLAEHDLTWEQLVDVGILCGTDFNPGIDGFGPTTALDAIGEHGDLWDVLAAEGEHVAHGDRIRELFLNPDVTDDYVIDPDVSPAIDAARAFVTDEWEVDADAVARGFERIDAAAAQTGLDRWT

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Flap endonuclease 1

327 amino acids

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.

35.814 kDa

MGNADLRQLAAIEETPFADLEGSVVAVDAHNWLYKYLTTTVQWTGADVYTTSDGTEVANLVGAVQGLPKFFEHGLTPVFVWDGGVTELKDDEIADRREQRERYEEQLDDAREAGDAAEAARLDARTQRLTPTIHETTRELFDLLDIPQVEAPAEGEAQAAYMTRTDDAVDYAGSDDYDCLLLGSPVTLRQLTSSGHPELMDFDATLAEHDLTWEQLVDVGILCGTDFNPGIDGFGPTTALDAIGEHGDLWDVLAAEGEHVAHGDRIRELFLNPDVTDDYVIDPDVSPAIDAARAFVTDEWEVDADAVARGFERIDAAAAQTGLDRWT

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Flap endonuclease 1

327 amino acids

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.

37.365 kDa

MGVKLKDIIQPEQIDFKDLKGRAISIDAFNTLYQFLSTIRQRDGRPLSDSNGNITSHLSGILYRNSSMIEKDIKPIYVFDGTPSYLKQETIDQRRQTREESEKKWKEALAKQDTQEARKYAMRSSKLSPYIIESSKKLLTMMGIPYIEAYGEGEAQAAYLVENGDAWAVASQDYDCLLFGAKRVVRNLAINSNLGDLEYYNLKRVLDELDINREQLIDMGILIGTDFSEGLKGVGAKTALKLAKKGELENKLAKLQEESSHDISEVREIFLNHNVNTNYKIRWKKPAKNDIIDFLCEEHGFSQDRVSKACDKLKNLNSSQKSLEDWF

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Flap endonuclease 1

326 amino acids

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.

36.132 kDa

MGNADLRSLAALSDVSFDDLGGSVVAVDAHNWLYRYLTTTVKFTSESKYTTSNGEEVANLIGVVQGLPKFFEHDMTPVFVFDGAVTDLKDDEVEKRREQRQKYESELEAAREAGDSTRVAKLDSRTQRLTDTIVDTTRDLLELLDVPIVDAPAEGEGQASVMARRGDVDYVGTEDYDALLFGAPMTLRQITSKGDPELMDFAATLEHHDLTWEQLVDAAILMGTDFNEGISGIGPKTAVKDLHEHGDLYTVLAARGEHIDHADRIRDLFLDPAATDDYEIPDSIEPDIDAARTFVTDQWEVDADEVARGFERIDDSVVQTGLDRWA

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Flap endonuclease 1

326 amino acids

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.

35.991 kDa

MGNAALRQLAALESVAFDDISGSVIAVDAHNWLYRYLTTTVKFTSDAAYTTESGVEVANLIGVVQGLPKFFEHDLTPVFVFDGGVTELKDEEVQERRVAREEAVELQAAAEERGDELAASRLEARTQRLTETIHETTRGLLNRLDVPIIEAPAEGEAQAAEMAIRGDVDYVGSEDYDTLLFGAPYTVRQLTSKGDPELMDLQTTLKNQNLTREQLVDVAILCGTDFNDGISGIGPATAISAINDHGDLWSVLDARDEFIQHADRVRSLFLDPPVTNEYTLHTTINPDMDAARSYVVDDWEVPADEVERGFERIETSVVQTGLDEWI

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Flap endonuclease 1

326 amino acids

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.

37.436 kDa

MGVQFNDSIPKKNISITDLKNKTVAIDSMNIIYQFLSSIRLRDGAPLRNSKGEITSPYNGIFYKTIYLLNNEITPIWVFDGKPPELKLKTREERRKVKEKASKDYEIAKREENIEDMQKYAKRINYLEPNTVDNCKKLLKLMGIPYIDAPSEGEAQCAHMIKNGDAYCVVSQDYDALLYGAPRTVRNITASNKPLELMEIEDILKPLDISIDDLIDMAILIGTDYNIGGIKGIGPKKALTIIKNKKMNEYIKDIENYEEIKNIFKNPKVVDYTKEDIKLKSPNIEGLKEFLIEENDFSPNRILPSIKKLDKLLNEKRSQTSLDSWF

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Flap endonuclease 1

326 amino acids

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.

Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.

37.527 kDa

MGVQFGDFIPKNIISFEDLKGKKVAIDGMNALYQFLTSIRLRDGSPLRNRKGEITSAYNGVFYKTIHLLENDITPIWVFDGEPPKLKEKTRKVRREMKEKAELKMKEAIKKEDFEEAAKYAKRVSYLTPKMVENCKYLLSLMGIPYVEAPSEGEAQASYMAKKGDVWAVVSQDYDALLYGAPRVVRNLTTTKEMPELIELNEVLEDLRISLDDLIDIAIFMGTDYNPGGVKGIGFKRAYELVRSGVAKDVLKKEVEYYDEIKRIFKEPKVTDNYSLSLKLPDKEGIIKFLVDENDFNYDRVKKHVDKLYNLIANKTKQKTLDAWFK