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fbxl7

Gene
FBXL7
Protein
F-box/LRR-repeat protein 7
Organism
Homo sapiens
Length
491 amino acids
Function
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of AURKA during mitosis, causing mitotic arrest.
Similarity
Belongs to the FBXL7 family.
Mass
54.575 kDa
Sequence
MGANNGKQYGSEGKGSSSISSDVSSSTDHTPTKAQKNVATSEDSDLSMRTLSTPSPALICPPNLPGFQNGRGSSTSSSSITGETVAMVHSPPPTRLTHPLIRLASRPQKEQASIDRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIRLTGETINVDRALKVLTRRLCQDTPNVCLMLETVTVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLDVSGCSKVTCISLTREASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTIAAHCTQLTHLYLRRCVRLTDEGLRYLVIYCASIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAHCGRVTDVGIRYVAKYCSKLRYLNARGCEGITDHGVEYLAKNCTKLKSLDIGKCPLVSDTGLECLALNCFNLKRLSLKSCESITGQGLQIVAANCFDLQTLNVQDCEVSVEALRFVKRHCKRCVIEHTNPAFF
Protein
F-box/LRR-repeat protein 7: FBXL7

Gene
Fbxl7
Protein
F-box/LRR-repeat protein 7
Organism
Mus musculus
Length
491 amino acids
Function
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of AURKA during mitosis, causing mitotic arrest.
Similarity
Belongs to the FBXL7 family.
Mass
54.646 kDa
Sequence
MGANNGKQYGSEGKGSSSVSSDVSSSTDHTPTKAQRNVATSEDSDLSMRTLSTPSPALICPPTLPGFQNGRGSSTSSSSITGETVAMVHSPPPTRLTHPLIRLASRPQKEQASIDRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIRLTGETINVDRALKVLTRRLCQDTPNVCLMLETVIVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLDVSGCSKVTCISLTREASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTIAAHCTQLTHLYLRRCVRLTDEGLRYLVIYCTSIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAHCGRITDVGIRYVAKYCSKLRYLNARGCEGITDHGVEYLAKNCTKLKSLDIGKCPLVSDTGLESLALNCFNLKRLSLKSCESITGQGLQIVAANCFDLQMLNVQDCEVSVEALRFVKRHCKRCVIEHTNPAFF
Protein
F-box/LRR-repeat protein 7: Fbxl7

Gene
fbxl7
Protein
F-box/LRR-repeat protein 7
Organism
Danio rerio
Length
489 amino acids
Function
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Similarity
Belongs to the FBXL7 family.
Mass
54.22 kDa
Sequence
MGANNGKQSGSEGKGSSSISSDLSSSTDQTSTKAPKNAATSEDSDLSMRTVSTPSPALILPPRSSSAVLNGSSTSSSTFGTETIAMVHMPPTSLTHPQRCLRQPRDQQGAPVDILPDHAFLQIFTHLPTNQLCRCARVCRRWYNLAWDPRLWRTIRLTGDVLHVDRALRVLTRRLCQDTPNVCLTVETVMVSGCRRLTDRGLYTVAQSCPELRRLEVAGCYNVSNEAVFEVVSRCPNLEHLDVSGCSKVTCISLTRDVSVKLSPLHGQQISIRFLDMTDCFALEDEGLHTIAAHCTQLTHLYLRRCVRLTDEGLRFLVIYCPGVRELSVSDCRFISDFGLREIAKLEGRLRYLSIAHCSRITDVGVRYVAKYCSRLRYLNARGCEGLTDHGIEHLAKSCLKLKSLDIGKCPLVSDAGLEQLALNSFNLKRLSLKSCESITGRGLQVVAANCFDLQLLNVQDCDVSLEALRFVKRHCKRCIIEHTNPAFF
Protein
F-box/LRR-repeat protein 7: fbxl7