fbxA

F-box/WD repeat-containing protein A

1247 amino acids

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. May target the cAMP phosphodiesterase regA for degradation leading to an increase in cAMP and PKA activity. Promotes development of prestalk cells as opposed to prespores within the developing fruiting body. Required for culmination and fruiting body development.

142.388 kDa

MQYVNGNDISSQSIHEVLELAFSTKIPWTKLEYESSEKHIIHSYSSHERGIYLSKGVAEFNISPENMYELLLDISSRSKWDFHCREAHIIEEYDHLNHIIHLNFTNPLISNLDMNLYRSCKYDPQERLFVIAMRSIELEDGDVDQFECLPNGWVIQGLRGQKDKCKMTFVQQCDLRDIELQRIPGYKSFNSKERLEDFQFLTLFPATVSGRLAKIFESIELYISNNVKDIETKDIRISIMEKAEKEVNEMFGTTNPDYGWKIYLKKLDMEILIKKTTSGYYMIGKGSFSSRYSPELLADVLYQKNPFEWDTFYDKTKLVESINSSIREVEVHYRMWRNTITMRLLQSVKKGPGNFSSVHWRSICSPNYQVADGIEVHYLPTALLNYGLGDGSFTSFLAAIEVKGYPTPWEEEMVTKMFAARIISNQNSIINHVNKLTGGSEMIRELPVIPSVQHHCGDVGSHIGTPQVYNAMVENFADILLDEGNKDGNVVSSKNKRKRNKNNENKNNNNDNIIDEEIEQEEENIEKDQQQTQQQQTQKQQQQQQQQQKTQQQPQQQQQQPQEQQQNHSQLKKEIKPTRPSIRFTYLLSNSSSGQRPIAWYESKKQPFLFLVSDSSERKGKIQRKTYYFSNSGFDNLPEEVVQIIFSNLSAINIVNLSLVCKRFKMATDSPILWKNLYKSNPLFHKKTPKRKQIIHSNLSNDENKVNSNSGDSADGSSSQEEEEQQQQNQQQNQQQNQQQQQQQTFDLSNINLNDPISLLMVFTNGIIPQNLSPTEIINVGGIVSQIDLNDLSNVETLIQQLPHQVLSLIQMNTLDAKIQHLSMISGMPATIGQESPINKNSSDNPKPNAYNKRDNNSYIPDEEFINWKSHYTEKHKQSKRWVNMEPIRITPLKGHNRAIKAVKSEGNSAITVSTEKKIKFWNLNTGQCIGDYEGESGVLSVEYDHTQKSSCIWPLSDYTKVHIGHKNGTVTMVDFIEQPIEVIHTSRPTNLADGFDFTFPGKYLIWEHTIIHYWDVETSTLLWNELNAHTKKITQSKIVAQHELSNKGIVFTTSSDKSAKVWDLTNGTCINTLVGHSYAVNCIEPIGDYMALTGSTDKTLKLWDLRQASTFISSYSTKHTGPIRCISYQEKNGIVLSGSDDGSIIAFNLDNWNLSNISVVKKPIFNNVIGNIGTTTTTTTTTTTTTTTTTSTTNNTNVPEIPKINLGTFKDSKRLHNHESAVTCIESDEAGFISGSQNGLVLRWDF