Organism
Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
Function
Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.
Similarity
In the C-terminal section; belongs to the radical SAM superfamily. CofH family.
Sequence
MTTSATSGTGPTANSMRRALKRARDGVALDVTEAAVLLQARGEDLDDLTASAARVRDAGLEAAGRAGVITYSKSVFIPLTRLCRDKCHYCTFVTVPGKLRRAGHGMFMSPDEVLDIARKGAALGCKEALITLGDKPEDRWPEAREWLDAHGYDDTIAYVRAISIRILEETGLLPHLNPGVMSWTDFQRLKPVAPSMGMMLETTATRLWSEPGGPHHGSPDKEPAVRLRVLEDAGRSSVPFTSGILIGIGETYEERAESLFALRKISRAYHGIQELIIQNFRAKPDTAMRGMPDAELDELIATVAVARHIMGPRACLQAPPNLVDSEYGRLIGAGIDDWGGVSPLTIDHVNPERPWPQIDLLREQSAQAGFELRERLCVYPEFVQRGEPWLDPRLLPHVRALADPASGLAHADATVEGHPWQEPEEAFVAQGRTDLHHSIDTEGRTGDRRDDFDVVYGDWEALREAAAPGMVPERIDTDVRQALATAANDPTRLTDAEALALLHADGPALDALTRIADDVRKAAVGDDVTYIVTRNINFTNVCYTGCRFCAFAQRRTDADAYTLSLEQVADRAQQAWDVGAVEVCMQGGIHPDLPGTAYFDIAKAVKERVPGMHVHAFSPMEVVNGATRTGLSIREWLTAAKEAGLDSIPGTAAEILDDEVRWVLTKGKLPTATWIEVITTAHELGIRSSSTMMYGHVDQPRHWLGHFRTLARIQQQTGGFTEFVTLPFIHTNAPVYLAGIARPGPTTRDNRAVMAMARLLLHPHIPNIQTSWVKLGTEGAAEMLRSGANDLGGTLMEETISRMAGSSYGSYKSVKDLIAVAEAAGRPAKPRTTLYGEVPQERQRAAAASDGHLPELLPVLD