fadD3

3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl:CoA ligase

515 amino acids

Involved in the catabolism of the rings C and D of cholesterol. Catalyzes the ATP-dependent CoA thioesterification of 3aalpha-H-4alpha(3'-propanoate)-7abeta-methylhexahydro-1,5-indanedione (HIP).

Belongs to the ATP-dependent AMP-binding enzyme family.

55.543 kDa

MTEQPTTTPSALKRAAREFGELTAVADGDVRLTFTQLHDRVRDFAAALSSQDVRPGDHVAVWSPNTYHWVVAALGIHYAGATLVPINTRYTATEALDILERTKTTALVVAGNFLGTDRYASLRDESSTFDLPTVVRVPVDGGDAELPGVFDFDDFLALADEDTRAEADARAAAVSPDDVSDVMFTSGTTGRSKGVMSAHRQSVGIAQAWGECAEVTSDDNYLIINPFFHTFGYKAGFLVCLLNGATVVPMAVFDVPKVMATVHDEQITVLPGAPTIFQSILDHPDRPKYDLSSLRVAITGAAAVPVALVERMQSELSFDAVLTAYGQTEAVVVTMCRTDDDPVTVSTTSGRAIPGMEVRIGDQGEILVRGENVMLGYLDDPESTAKTIDADGWLHTGDVGTLDDRGYVDITDRLKDMYISGGFNVYPAEVENALARLDGVAESAVIGVPDERMGEVGRAYVVAKPGVTLAEDDVVAFCKERLANFKVPRSVRFVDSLPRNPSGKVMKNVLREEKK

fadD3

3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl:CoA ligase

507 amino acids

Involved in the catabolism of the rings C and D of cholesterol. Catalyzes the ATP-dependent CoA thioesterification of 3aalpha-H-4alpha(3'-propanoate)-7abeta-methylhexahydro-1,5-indanedione (HIP) to yield HIP-CoA. It can also use the hydroxylated analogs of HIP, 5alpha-OH HIP and 1beta-OH HIP. It requires that the side chain at C17 is completely removed.

Belongs to the ATP-dependent AMP-binding enzyme family.

54.095 kDa

MINDLRTVPAALDRLVRQLPDHTALIAEDRRFTSTELRDAVYGAAAALIALGVEPADRVAIWSPNTWHWVVACLAIHHAGAAVVPLNTRYTATEATDILDRAGAPVLFAAGLFLGADRAAGLDRAALPALRHVVRVPVEADDGTWDEFIATGAGALDAVAARAAAVAPQDVSDILFTSGTTGRSKGVLCAHRQSLSASASWAANGKITSDDRYLCINPFFHNFGYKAGILACLQTGATLIPHVTFDPLHALRAIERHRITVLPGPPTIYQSLLDHPARKDFDLSSLRFAVTGAATVPVVLVERMQSELDIDIVLTAYGLTEANGMGTMCRPEDDAVTVATTCGRPFADFELRIADDGEVLLRGPNVMVGYLDDTEATAAAIDADGWLHTGDIGAVDQAGNLRITDRLKDMYICGGFNVYPAEVEQVLARMDGVADAAVIGVPDQRLGEVGRAFVVARPGTGLDEASVIAYTREHLANFKTPRSVRFVDVLPRNAAGKVSKPQLRELG