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fadD26

Gene
fadD26
Protein
Long-chain-fatty-acid--AMP ligase FadD26
Organism
Mycobacterium marinum (strain ATCC BAA-535 / M)
Length
584 amino acids
Function
Catalyzes the activation of long-chain fatty acids (C22-24 fatty acids) as acyl-adenylates (acyl-AMP), which are then transferred to the multifunctional polyketide synthase PpsA for further chain extension. Involved in the biosynthesis of phthiocerol dimycocerosate (DIM A) and phthiodiolone dimycocerosate (DIM B) (By similarity).
Similarity
Belongs to the ATP-dependent AMP-binding enzyme family.
Mass
62.953 kDa
Sequence
MPVTDRSIPSLLKEQADQRPNETAFTFLDYDLDPNGFAETLTWSQVYARACVVADELTMYGVPGDRVAILAPQGLEYIVAFLGALQAGFIGVPLSTPQYGVHDERVSAVLRDSQPVAILTTSAVVGDVTKYASSQDGQPAPSVIEVDLLDLDTPRPQQALPQPASGSAYLQYTSGSTRTPAGVIVSHENVIANVTQSLYGYFGGPDKFPADTTVVSWLPLFHDMGLILGICAPLVTGCTAVLLSPMSFLRRPARWMQLLASHPKCFSAAPNFAFELAVRRTTDEDLAGLDLGDVLGIVSGSERIHVATIKRFTERFAPFNLSPAAVRPSYGLAEATLYVAAPEPGTTPRTVRFDYESLTAGHARPCRADGSVGTELISYGSPDPSAVRIVNPETMIENPSGTVGEIWAHGEHVAMGYWQKPEQSDRTFNARIVNPAPGTPEGPWLRTGDLGVMSNGELFIMGRIKDLVIVDGRNHYPDDIEATIQEITGGRVAAIAVPDNITEQLVAIIELKRRGASAEEAMVKLRSVKREITSAISKSHSLRVADVVLVPPGSIPITTSGKIRRAACVERYRSDGFNRLDVTV

Gene
fadD26
Protein
Long-chain-fatty-acid--AMP ligase FadD26
Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Length
583 amino acids
Function
Catalyzes the activation of long-chain fatty acids (C22-24 fatty acids) as acyl-adenylates (acyl-AMP), which are then transferred to the multifunctional polyketide synthase PpsA for further chain extension. Involved in the biosynthesis of phthiocerol dimycocerosate (DIM A) and phthiodiolone dimycocerosate (DIM B).
Similarity
Belongs to the ATP-dependent AMP-binding enzyme family.
Mass
63.012 kDa
Sequence
MPVTDRSVPSLLQERADQQPDSTAYTYIDYGSDPKGFADSLTWSQVYSRACIIAEELKLCGLPGDRVAVLAPQGLEYVLAFLGALQAGFIAVPLSTPQYGIHDDRVSAVLQDSKPVAILTTSSVVGDVTKYAASHDGQPAPVVVEVDLLDLDSPRQMPAFSRQHTGAAYLQYTSGSTRTPAGVIVSHTNVIANVTQSMYGYFGDPAKIPTGTVVSWLPLYHDMGLILGICAPLVARRRAVLMSPMSFLRRPARWMQLLATSGRCFSAAPNFAFELAVRRTSDQDMAGLDLRDVVGIVSGSERIHVATVRRFIERFAPYNLSPTAIRPSYGLAEATLYVAAPEAGAAPKTVRFDYEQLTAGQARPCGTDGSVGTELISYGSPDPSSVRIVNPETMVENPPGVVGEIWVHGDHVTMGYWQKPKQTAQVFDAKLVDPAPAAPEGPWLRTGDLGVISDGELFIMGRIKDLLIVDGRNHYPDDIEATIQEITGGRAAAIAVPDDITEQLVAIIEFKRRGSTAEEVMLKLRSVKREVTSAISKSHSLRVADLVLVSPGSIPITTSGKIRRSACVERYRSDGFKRLDVAV

Gene
fadD26
Protein
Long-chain-fatty-acid--AMP ligase FadD26
Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Length
583 amino acids
Function
Catalyzes the activation of long-chain fatty acids (C22-24 fatty acids) as acyl-adenylates (acyl-AMP), which are then transferred to the multifunctional polyketide synthase PpsA for further chain extension. Involved in the biosynthesis of phthiocerol dimycocerosate (DIM A) and phthiodiolone dimycocerosate (DIM B) (By similarity).
Similarity
Belongs to the ATP-dependent AMP-binding enzyme family.
Mass
63.044 kDa
Sequence
MPVTDRSVPSLLQERADQQPDSTAYTYIDYGSDPKGFADSLTWSQVYSRACIIAEELKLCGLPGDRVAVLAPQGLEYVLAFLGALQAGFIAVPLSTPQYGIHDDRVSAVLQDSKPVAILTTSSVVGDVTKYAASHDGQPAPVVVEVDLLDLDSPRQMPAFSRQHTGAAYLQYTSGSTRTPAGVIVSHTNVIANVTQSMYGYFGDPAKIPTGTVVSWLPLYHDMGLILGICAPLVARRRAMLMSPMSFLRRPARWMQLLATSGRCFSAAPNFAFELAVRRTSDQDMAGLDLRDVVGIVSGSERIHVATVRRFIERFAPYNLSPTAIRPSYGLAEATLYVAAPEAGAAPKTVRFDYEQLTAGQARPCGTDGSVGTELISYGSPDPSSVRIVNPETMVENPPGVVGEIWVHGDHVTMGYWQKPKQTAQVFDAKLVDPAPAAPEGPWLRTGDLGVISDGELFIMGRIKDLLIVDGRNHYPDDIEATIQEITGGRAAAIAVPDDITEQLVAIIEFKRRGSTAEEVMLKLRSVKREVTSAISKSHSLRVADLVLVSPGSIPITTSGKIRRSACVERYRSDGFKRLDVAV

Gene
fadD26
Protein
Long-chain-fatty-acid--AMP ligase FadD26
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Length
583 amino acids
Function
Catalyzes the activation of long-chain fatty acids (C22-24 fatty acids) as acyl-adenylates (acyl-AMP), which are then transferred to the multifunctional polyketide synthase PpsA for further chain extension. Involved in the biosynthesis of phthiocerol dimycocerosate (DIM A) and phthiodiolone dimycocerosate (DIM B).
Similarity
Belongs to the ATP-dependent AMP-binding enzyme family.
Mass
63.044 kDa
Sequence
MPVTDRSVPSLLQERADQQPDSTAYTYIDYGSDPKGFADSLTWSQVYSRACIIAEELKLCGLPGDRVAVLAPQGLEYVLAFLGALQAGFIAVPLSTPQYGIHDDRVSAVLQDSKPVAILTTSSVVGDVTKYAASHDGQPAPVVVEVDLLDLDSPRQMPAFSRQHTGAAYLQYTSGSTRTPAGVIVSHTNVIANVTQSMYGYFGDPAKIPTGTVVSWLPLYHDMGLILGICAPLVARRRAMLMSPMSFLRRPARWMQLLATSGRCFSAAPNFAFELAVRRTSDQDMAGLDLRDVVGIVSGSERIHVATVRRFIERFAPYNLSPTAIRPSYGLAEATLYVAAPEAGAAPKTVRFDYEQLTAGQARPCGTDGSVGTELISYGSPDPSSVRIVNPETMVENPPGVVGEIWVHGDHVTMGYWQKPKQTAQVFDAKLVDPAPAAPEGPWLRTGDLGVISDGELFIMGRIKDLLIVDGRNHYPDDIEATIQEITGGRAAAIAVPDDITEQLVAIIEFKRRGSTAEEVMLKLRSVKREVTSAISKSHSLRVADLVLVSPGSIPITTSGKIRRSACVERYRSDGFKRLDVAV