Protein
3-oxoacyl-[acyl-carrier-protein] synthase 3 protein 3
Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Function
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
Similarity
Belongs to the thiolase-like superfamily. FabH family.
Sequence
MTRASVLTGLGSCLPSRCVTNAELERTMDTSDEWIRARTGIAQRYVAEEGTLTSDLAVGAAERALKSARLTPDEIDAVIVATTTPDRPCPATAPTVAARLGTGPVPAFDVSAVCSGFLYGLATGSGLIASGAAERVLVIGAETFSRILNPQDRSTSVIFGDGAGAVVLRAGEPGETGALGPLRLGSDGTGVDLITVPAGGPPRPGAAAPDDLADRYFTMEGKRVFWLAVQRMGECAESVLDRAGWRVADVDWLVSHQANHRITARLADEIGIPRERSVSNIAEVGNTAAASIPLALDHAHARGTLRPGDRVLLTAFGGGLTWGAAALTWPAVDPV