FAB1

1-phosphatidylinositol 3-phosphate 5-kinase FAB1

2278 amino acids

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. The product of the reaction it catalyzes functions as an important regulator of vacuole homeostasis perhaps by controlling membrane flux to and/or from the vacuole. Hyperosmotic shock-induced increase in the levels of PtdIns(3,5)P2 requires the presence of VAC7, VAC14, and/or FIG4.

257.42 kDa

MSSEEPHASISFPDGSHVRSSSTGTSSVNTIDATLSRPNYIKKPSLHIMSTSTTSTTTDLVTNPILSNISVPKISPPTSSSIATATSTSHVTGTASHSNIKANANTSTSVNKKNLPPTTSGRIPSSTIKRYPSRYKPSHSLQLPIKNDSNFKRSSIYASKSTVTAIPIRNNRPISMQNSYARTPDSDHDDVGDEVSSIKSASSSLTASLSKSFLFAFYNNRKKDKTSNNGVLSKEYWMKDESSKECFSCGKTFNTFRRKHHCRICGQIFCSSCTLLIDGDRFGCHAKMRVCYNCYEHADTYEDSSDEENDSTMQLNEPRSRSRSRSSNTNPYSHSHSHLHLISQDNHNGTDLHDPVAATDNPQQQNEVYLLNDDDVQSIMTSGEDSKLFISTPPPPPKMAIPATKQGGSLEISFDSENDRALHYQDDNPGRHHHLDSVPTRYTIRDMDNISHYDTNSNSTLRPHYNTNNSTITINNLNNTTSNNSNYNNTNSNSNINNPAHSLRRSIFHYVSSNSVNKDSNNSSATPASSAQSSSILDPANRIIGNYAHRNYKFKFNYNSKGPSQQNDTANGNNDNNNNNNNNNNNNNNNSASGIADNNNIPSNDNGTTFTLDKKKRNPLTKSKSTSAYLEYPLNEEDSSEDEGSMSIYSVLNDDHKTDNPIRSMRNSTKSFQRAQASLQRMRFRRKSKSKHFPNNSKSSIYRDLNFLTNSTPNLLSVVSDDNLYDDSSPLQDKASSSAASRLTDRKFSNSSGSNNNSNSNSNINTDPWKRIASISGFKLKKEKKRELNEVSLLHMHALLKQLLNDQEISNLQEWITLLDGALRKVLRTILNARDLNTLDFRQTYVKIKRISGGSPQNSEYIDGVVFSKALPSKTMPRHLKNPRILLIMFPLEYQKNNNHFLSIESVFRQEREYLDKLVSRLKSLHPDIIYVGANVSGYALELLNDSGIVVQFNMKPQVIERIAKLTEADIAISVDKLATNIKMGECETFEVKSYIYGNISKTYTFLRGCNPELGGTILLRGDSLENLRKIKQVSEFMVYAIFSLKLESSFFNDNFIQLSTDVYLKRAESKKLQVFEGYFADFLIKFNNRILTVSPTVDFPIPFLLEKARGLEKKLIERINQYESESDLDRQTQLNMLQGLESTITKKHLGNLIKFLHEMEIENLELEFQKRSRQWEVSYSSSQNLLGTGSHQSITVLYSMVSTKTATPCVGPQIVTIDYFWDSDISIGQFIENVVGTARYPCQQGCNGLYLDHYRSYVHGSGKVDVLIEKFQTRLPKLKDIILTWSYCKKCGTSTPILQISEKTWNHSFGKYLEVMFWSYKDSVTGIGKCPHDFTKDHVKYFGYNDLVVRLEYSDLEVHELITPPRKIKWKPHIDIKLKVELYYKILEKINNFYGSVLSRLERIKLDSMTKDKVLSGQAKIIELKSNATEEQKLMLQDLDTFYADSPCDQHLPLNLVIKSLYDKAVNWNSTFAIFAKSYLPSETDISRITAKQLKKLFYDSSRKDSEDKKSLHDEKAKTRKPEKNELPLEGLKDVEKPKIDSKNTTENRDRTNEPQNAVTITTFKDDTPIIPTSGTSHLTVTPSASSVSSSLTPQTEERPPISRSGTGISMTHDKSTRPNIRKMSSDSSLCGLASLANEYSKNNKVSKLATFFDQMHFDALSKEFELERERERLQLNKDKYQAIRLQTSTPIVEIYKNVKDAVDEPLHSRSSGNNLSSANVKTLEAPVGEHSRANNCNPPNLDQNLETELENSISQWGENILNPSGKTTASTHLNSKPVVKETSENPKSIVRESDNSKSEPLPPVITTTTVNKVESTPQPEKSLLMKTLSNFWADRSAYLWKPLVYPTCPSEHIFTDSDVIIREDEPSSLIAFCLSTSDYRNKMMNLNVQQQQQQQTAEAAPAKTGGNSGGTTQTGDPSVNISPSVSTTSHNKGRDSEISSLVTTKEGLLNTPPIEGARDRTPQESQTHSQANLDTLQELEKIMTKKTATHLRYQFEEGLTVMSCKIFFTEHFDVFRKICDCQENFIQSLSRCVKWDSNGGKSGSGFLKTLDDRFIIKELSHAELEAFIKFAPSYFEYMAQAMFHDLPTTLAKVFGFYQIQVKSSISSSKSYKMDVIIMENLFYEKKTTRIFDLKGSMRNRHVEQTGKANEVLLDENMVEYIYESPIHVREYDKKLLRASVWNDTLFLAKMNVMDYSLVIGIDNEGYTLTVGIIDFIRTFTWDKKLESWVKEKGLVGGASVIKQPTVVTPRQYKKRFREAMERYILMVPDPWYREGN

fab1

1-phosphatidylinositol 3-phosphate 5-kinase fab1

1932 amino acids

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (By similarity). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. The product of the reaction it catalyzes functions as an important regulator of vacuole homeostasis perhaps by controlling membrane flux to and/or from the vacuole (By similarity). Required for survival under conditions of nitrogen starvation. May have a role in the secretion of pheromone peptides.

220.135 kDa

MSEVETPTAASPTFPVETSHRLDTLHTSSTEQIIKDSENVVHTTLKLPTSTLSREFWMKDERTNNCSLCETEFTLFRRKHHCRICGKIICKYCLKEAPGFIFRLQGSIKVCRPCASILVNNYSRSQLFNHSLNESKNRDLTEQHPFVTLDELNSNDQVLSSFGDLSSTFEMPNNIHPPEVAPMIAIPSSRSNYDSPGWAHHSIFLDWSKRNLDSNVINVEDSESGKYNALTITNSYDAGPSSVSTDYRPVNFGKVPSYSKLRKNKAFSSAKVSDMYLSADERNRLEDFSKGDRGLSFVNLSPNIKATSYDRLSTVINEPFISRSSSLTDERGLADSGNSYHHFSDSDDESLFNDGLGLSFHANSAIIKQRQQNVASIQRYGNESYLSNFLKAFLPKTVCDYLFPSSTIPDGLPALIENFNARVDKVNHPGGTEEPLPYQGKSRASSVVTSSKSTCILPPWILFSDSFNQLVCTFLGKLLFQMLNDEGVDSPMQWVLCLPKILLKMALDLGPDIRSGDDIDVRSYVKIKKIPGGSIQDCFLVNGVLFSKKASSKSMDRSLRRPRIALLTFSLDYACDEQRILSLDLIISQQEEYIINLVNRICMLKPNLVFAQGQIPSIALKYFEEHGVIAFHGLKESVLYDIARCCRADIISSIDKLSLCPRLGTCGRFQLRTYVVDENKGLRKTFAILDRCSERLGCTIVLRGADYNQLSKVKKIVELVVLIAYHIKLECALLRDKFVNMPELFETTYQSLSRKSLPSFASTAADKEKSQNHEKKSLNSDNQSLRPLENENQSVSSTQGSNSPLELINNLPASDDYSSITKALKTRFLTFSPFLSKPLPRLLNQVNYYQFIRNKLLKDVKLHPYSPTGSFVMKQSENDNVEESYEESYKFFCIDERYHFLEKQWTLYYSHSKLMFSPFSSQRIILLYSIINKETSVPCIGPERCLLEFYRETDCTLGQYIEDSCLNTNVSCGGEYCKTNDMLWHYRSYVHGNSRISVFLESFSCPVPGLEEKIIMWSYCKFCKKNTHITVMSEETWKYSFGKYLEFMFYNSQIRDRFEFCDHSVMAQHVHYFGYCNMALRFQRDLIEIFELFVPSVTLRNNPSYIKELKEKEYKRLKGVIEKCLSSVASRINQIKCDWVTDPEKFESCTSEISKFRTLLSSDYTELYSEFDSIYLNSSTSDYLSLNSILRVLQGKMVKWEQRFLDYQRLYLPSYKELSKIAAAQIKKVFLERPLSQTPLDLPETLENTQIDIYPSFKTESTDDQLEKVTQTNVASNKRVAPYADSMANVGSPESDCFSVATSSDIPKANIDFTNDISTQNTFPASPVSNSGFSRQTYPNISQRQGVNMLSHKRKSASTSDRRFVNASSTSGMNMPISSSISAKISSIQNSTKYSPRKPIPAKDVRVSSLVRRFEELSLQLQEKQKRDEELIKARRKRALPVVPSKPVVEVFNDLNEAFDDENSEDENGINDTKENRATESNFSGVDSMSKERENVSSNEDNSPEAFEDIFGILFKNESGLEEQQNLEPSSQMDKEGSKLPTSGPLADKTSVYRILSAFWNEWNSLNPPPFEFPLQPTEHMFSDSNVIIREDEPSSLISFTLSSPDYLSKMVEIEDSMDEALTNQGLQGSTQFKIENLMLKPTGTHLKYQFEEGSARLSCKVFFAEQFSALRRACGCEETFVTSLARCSLWESSGGKSGSAFLKTFDKKYILKVLSRLESDSLLNFAPAYFDYISKVFFHELPTALTKIFGFYRVDIRNPTTGTICKTDIMIMENVFYDECPSRIFDLKGSMRNRHVESTGKVDEVLLDENLVELIYESPIFVSEQLKSLLHSCLWNDTLFLSKLNIMDYSLIVGIDYTKKELYVGIIDFIRTYTWDKKLESWVKEKGLVGRGPEPTIVTPKQYKNRFRKAMDCYILASQDFETGEGFKFCE

fab1

Putative 1-phosphatidylinositol 3-phosphate 5-kinase

1809 amino acids

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Has a role at a late stage in endosome-related membrane trafficking, at a point when signal termination has occurred. Is not required for receptor silencing.

204.635 kDa

MTSNNQNNSSSHQHLHSPSKLTEFARNFEDKPESLFGRVVNKIQNVYNQSYNTVNDISSGSSSSSSTQPVQVVGKSQFFSDSQTSTAEIADVETSSQSSVRPQPPTTLSIRTNSETRGTSTSSNTAAEDSETSDRVETLPLPTSEANQGRTVSNVLKHISNIVATKNNNDLRNYKDTELQRFWMPDSKAKECYDCSQKFSTFRRKHHCRLCGQIFCSKCCNQVVPGMIIRCDGDLKVCNYCSKIVLTFLKSSSSEMGQDMQELQQHLSNKLEVQDSGSSLAKHPQMQRAPLPRKTSVGYQEERFSSHPTYTTLSIDDRKNILQQSNSLITLHEEMQRDLPAQNCGQRLIEFLNSNNKSANEVQAVAILNAMLAAGFLEPIVPDPEQMDFDSSLHYKFSKSSSSDTSRTMSPQFEANPHAEPQPPKSMDQSAEEKEKELENELENDRCYTTATSKLLASYCEHEEQLLAQMLRAHNLDQEWDKVLQMLCSTAANHFKPEHCSNDLMDIRNYVNFKKVPGGRRKDSKIVHGVAFSKNVAHKDMATHVPFPRILLLQCPIVYERIEGKFVTIETVLLQEKEYLRNVCARIMSFKPNVVLVHKNVAGIAQDLLRSYEVTLVLDVKLSVMERLSRTLQCDIVSSIESNITMPKLGYCNDFYIRNYNGKTLMFFEKLTNPRGYTCLLRGGSNAELTRVKRVASALLFARYNWRLEMSFLLNEFAQPLSPKPSIFDSKETSPKTETEAELRSKRPIILERKSEDKITTIVSENVSDFTDPLRASQAEALSTSPCAPPVVEALAVEPRYDNRFRTALSSTLLSVSPFLTFPLPYLETEQGRKCKLRKLFPAELYFSKQWSRTGLERPDSMGDGEAGKSEPGNKENQMQLLPAHDFVLMKITAPASSRDIQSKLAEFRSFGGRLPKGKAPMLRPKKKNAEVIQRPQKVSEEQLYKDALDPQNHQRLPVLFCSFHYNPKGVSSFCKLPMLLDMKFYGQYDIMLEQFLQRYCCLFNSMCPSCNLPMLGHVRRYVHSLGCVHVYLTEDLTRSDPTRIYFTSWCSICNATTPTIPLSDAAKCLSLAKYLEMRFHGHAYKRRPPSTDAEQGGTVCEHSLHRDYVHHFSFRGVGAKFQYTPVEVWETDLPSLTVQLDLPQPFQSAQVQEEIKNFSIKGHEVYNRIHERIADLATEEENSPLVQHLKTMLTHDQFIFKQKIEIVHTLLTDNRATAYDTSDALAMARRALAESIELWGPRLQEIEKLTAKQAHHIDSGTICTEELRPEQVQTADSSKVTTSSLPKENDPLECPSEDTETGASNSQTVLDKNFSIDQMLASTVNVYSDKKSIRKILTQLLPSGNQVNPLQSPFPAQDHLTLPLGSIPIHVRETDLSSVIAYSLTSMDYQKAIDEAEANSNAAHSSPQLKRKIPLAESVSDAEDSPSLSRTSSNTSAAPNASVPSPATAASESEEKSKERIKQPPSPHITLAFQDHSCQFQCKIYFAREFDAMRSKSLKPPKLDKSLYRRLEKSKMREELRISQSRTGSEMELVRKPSDVGAPRTTEDDSNQEEDARIALARSLCKSVQWEARGGKSGSRFCKTLDDRFVLKEMNSRDMTIFEPFAPKYFEYIDRCQQQQQPTLLAKIFGVFRVSVKKKDSFVERSVMVMENLFYGCNIENKFDLKGSERNRLVDPSNQQGEIVLLDENLVQMSWSKPLYVLSHSKTVLRDAIQRDSSFLEKNLVMDYSLLVGLDKKNGVLVLGIIDYIRTFTLDKRVESIIKGSGILGGKGKDPTVVNPERYKQRFIDAMDRYFLTVPDRWEGLSKV