Protein
Histone-lysine N-methyltransferase EZH2
Function
Polycomb group (PcG) protein. Catalytic subunit of the prc2/eed-ezh2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. May regulate the circadian clock via histone methylation at the promoter of the circadian genes.
Similarity
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. EZ subfamily.
Sequence
MGQTGKKSEKGAVCWRKRVKSEYMRLRQLKRFRRADEVKSMFNTNRQKIMERTEILNQEWKQRRIQPVHIMTTVSSLRGTRECFVTSDLDFPKQVIPLKTLTAVASMPIMYSWSPLQQNFMVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALAQYSDYEDDEDGEDNQDDERDDITKDQDDNMEEKETLPLRKFPSDKIFEAISSVFPDKGTSEELKEKYKELTEQQLPGALPPECTPNIDGSNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFHATPNTYKRKNNEAANDGKLCGPYCYQLLEGAREFAAALTAEIIKTPPKRPSGRRRGRLPNNSSRPSTPTVNVLEAKDTDSDREAGTETGGESNDKEEEEKKDETDSSSEANSRCQTPIKMKPNIEPPENVEWSGAEASLFRVLIGTYYDNFCAIARLISTKTCRQVYEFRVKESSIIAPVIAEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCSSDCQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIYIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSLNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYSQADALKYVGIEREMEIP