About Products Protein Database Contact

eya-1

Gene
eya-1
Protein
Eyes absent homolog 1
Organism
Caenorhabditis elegans
Length
503 amino acids
Function
Tyrosine protein phosphatase (By similarity). Acts probably as a transcription regulator in the embryonic and postembryonic development of several tissues including pharynx, vulva and gonads (PubMed:16154558). Required for the development of anterior tissues during late embryogenesis (PubMed:16154558). Together with ceh-34, required to specify the coelomocyte fate in embryonic and postembryonic precursors (PubMed:19427847). In the anterior part of the embryo, prevents apoptosis in cells that are not fated to die (PubMed:16154558). Together with ceh-34 activates proapoptotic factor egl-1 expression to promote motor neuron M4 sister cell apoptosis (PubMed:20713707). Also promotes apoptosis of I1 pharyngeal neuron sister cell (PubMed:20713707). Plays a role in locomotion and fertility (PubMed:16154558). May play a role in resistance to heat and oxidative stresses (PubMed:25108328).
Similarity
Belongs to the HAD-like hydrolase superfamily. EYA family.
Mass
54.522 kDa
Sequence
MLPDSEGQKLKTFLLGTGTTLDPSLDPTGNSNFSMATTSDSSTIWTALPASQPGDKDIPTVDLAAISEAYGSTSSTTSLTSSVTSQYQYNSYPQYAMYTSANPANYYQQVTANLRAGTTAFPYSLTTPSYYGSYPVDYTSAAAAYQNPYYTNLRGGTAAPYYNPLNATTAAAYASVASSVLGTDAVNLGTSSDGSTGVPSTVTSFSLKEKKPKVSKKKKTGSCSPGDETYARVFIWDIDDIAVISRNYLASVTHTNEFYARAANSVSHLMERIALNNFADVNEFLEGDITNIEDAVVDETTMDSGPIDNLRGLDVMRRVAPKYSAFRQFYTENSTKNDVAGFKQEQNGFNFELLERVGFGAREATELYQSAIQLQTLPNFGQRWPCAQRCMDLVVEKSKLSAEKYANVVLSNDGLVLGAAQLMISGLNSSVPVENIYSISKQGKESVFEKIQSRFGKKCSFICITSGDTANSAKRLNIPVWPLNSNTDLDKLYSALDNFLLGG